| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 29 | 4.212838e-29 | 0 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 29 | 2.276740e-28 | 0 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 50 | 4.713394e-25 | 0 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 27 | 3.136444e-17 | 0 |
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 11 | 1.387415e-16 | 0 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 46 | 5.117901e-14 | 0 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 58 | 8.636170e-13 | 0 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 11 | 2.218303e-12 | 0 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 28 | 1.707847e-11 | 0 |
| GO:MF | GO:0097718 | disordered domain specific binding | "Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698] | 8 | 1.322780e-10 | 0 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 25 | 2.113148e-10 | 0 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 17 | 2.183962e-10 | 0 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 34 | 1.165325e-09 | 0 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 15 | 4.242287e-09 | 0 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 26 | 6.054283e-09 | 0 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 85 | 7.696643e-09 | 0 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 10 | 2.073062e-08 | 0 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 20 | 3.724648e-08 | 0 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 10 | 4.463785e-08 | 0 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 19 | 4.901746e-08 | 0 |
| GO:MF | GO:0042826 | histone deacetylase binding | "Binding to histone deacetylase." [GOC:jl] | 10 | 6.659584e-08 | 0 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 31 | 3.317747e-07 | 0 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 17 | 3.780445e-07 | 0 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 14 | 7.985683e-07 | 0 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 26 | 8.768657e-07 | 0 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 29 | 1.339123e-06 | 0 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 16 | 1.612989e-06 | 0 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 31 | 1.891273e-06 | 0 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 31 | 2.265014e-06 | 0 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 29 | 2.566085e-06 | 0 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 29 | 3.072010e-06 | 0 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 16 | 3.771561e-06 | 0 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 24 | 4.016759e-06 | 0 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 15 | 5.622698e-06 | 0 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 32 | 6.459970e-06 | 0 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 24 | 6.829933e-06 | 0 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 31 | 7.077385e-06 | 0 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 53 | 7.115196e-06 | 0 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 52 | 7.709829e-06 | 0 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 31 | 8.214401e-06 | 0 |
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 8 | 1.271683e-05 | 0 |
| GO:MF | GO:0031072 | heat shock protein binding | "Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw] | 8 | 3.773424e-05 | 0 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 20 | 4.155942e-05 | 0 |
| GO:MF | GO:0003712 | transcription coregulator activity | "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] | 13 | 6.201843e-05 | 0 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 20 | 9.154648e-05 | 0 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 20 | 9.272174e-05 | 0 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 20 | 9.272174e-05 | 0 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 29 | 1.035786e-04 | 0 |
| GO:MF | GO:0042162 | telomeric DNA binding | "Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624] | 5 | 2.505777e-04 | 0 |
| GO:MF | GO:0003725 | double-stranded RNA binding | "Binding to double-stranded RNA." [GOC:jl] | 6 | 2.992292e-04 | 0 |
| GO:MF | GO:0043021 | ribonucleoprotein complex binding | "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] | 8 | 3.337596e-04 | 0 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 12 | 4.311880e-04 | 0 |
| GO:MF | GO:0140693 | molecular condensate scaffold activity | "Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate." [PMID:28225081] | 5 | 5.960248e-04 | 0 |
| GO:MF | GO:0030235 | nitric-oxide synthase regulator activity | "Binds to and modulates the activity of nitric oxide synthase." [GOC:mah] | 3 | 1.187253e-03 | 0 |
| GO:MF | GO:0019903 | protein phosphatase binding | "Binding to a protein phosphatase." [GOC:jl] | 7 | 1.243961e-03 | 0 |
| GO:MF | GO:0140296 | general transcription initiation factor binding | "Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation." [GOC:txnOH-2018] | 5 | 1.363571e-03 | 0 |
| GO:MF | GO:0023026 | MHC class II protein complex binding | "Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw] | 4 | 1.386254e-03 | 0 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 28 | 3.813631e-03 | 0 |
| GO:MF | GO:0004517 | nitric-oxide synthase activity | "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, RHEA:19897] | 3 | 4.033624e-03 | 0 |
| GO:MF | GO:0098505 | G-rich strand telomeric DNA binding | "Binding to G-rich, single-stranded, telomere-associated DNA." [PMID:11349150] | 3 | 4.033624e-03 | 0 |
| GO:MF | GO:0001221 | transcription coregulator binding | "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] | 6 | 4.983327e-03 | 0 |
| GO:MF | GO:0023023 | MHC protein complex binding | "Binding to a major histocompatibility complex." [GOC:mtg_signal, GOC:vw] | 4 | 5.186856e-03 | 0 |
| GO:MF | GO:0140666 | annealing activity | "An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule." [PMID:22888405] | 3 | 5.529402e-03 | 0 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 20 | 6.193420e-03 | 0 |
| GO:MF | GO:0043047 | single-stranded telomeric DNA binding | "Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] | 3 | 7.350167e-03 | 0 |
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 9 | 7.413963e-03 | 0 |
| GO:MF | GO:0019902 | phosphatase binding | "Binding to a phosphatase." [GOC:jl] | 7 | 7.597726e-03 | 0 |
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 5 | 8.139101e-03 | 0 |
| GO:MF | GO:0051087 | protein-folding chaperone binding | "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443] | 6 | 1.029070e-02 | 0 |
| GO:MF | GO:0098847 | sequence-specific single stranded DNA binding | "Binding to single-stranded DNA of a specific nucleotide composition." [PMID:9531483] | 3 | 1.208752e-02 | 0 |
| GO:MF | GO:0048156 | tau protein binding | "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] | 4 | 1.515088e-02 | 0 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 47 | 1.604008e-02 | 0 |
| GO:MF | GO:0051787 | misfolded protein binding | "Binding to a misfolded protein." [GOC:ai] | 3 | 1.848358e-02 | 0 |
| GO:MF | GO:1990381 | ubiquitin-specific protease binding | "Binding to a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750] | 3 | 2.677017e-02 | 0 |
| GO:MF | GO:0061980 | regulatory RNA binding | "Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme." [PMID:14622403, PMID:23475961] | 4 | 2.990603e-02 | 0 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 15 | 3.025899e-02 | 0 |
| GO:MF | GO:0008013 | beta-catenin binding | "Binding to a catenin beta subunit." [GOC:bf] | 5 | 4.421023e-02 | 0 |
| GO:MF | GO:0003713 | transcription coactivator activity | "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 7 | 4.534824e-02 | 0 |
| GO:MF | GO:0031593 | polyubiquitin modification-dependent protein binding | "Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg] | 4 | 4.965166e-02 | 0 |
| GO:MF | GO:0140677 | molecular function activator activity | "A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators] | 15 | 4.974161e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 60 | 1.116851e-24 | 0 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 68 | 6.116466e-23 | 0 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 56 | 1.614096e-22 | 0 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 44 | 1.358808e-21 | 0 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 51 | 1.392518e-21 | 0 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 44 | 2.362929e-21 | 0 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 19 | 1.361855e-19 | 0 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 39 | 1.658670e-19 | 0 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 48 | 2.515115e-19 | 0 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 43 | 4.053338e-19 | 0 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 32 | 4.331502e-19 | 0 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 43 | 4.386604e-19 | 0 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 38 | 6.620819e-19 | 0 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 69 | 6.637656e-19 | 0 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 42 | 1.164284e-18 | 0 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 37 | 1.218743e-18 | 0 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 31 | 2.173109e-18 | 0 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 37 | 2.534977e-18 | 0 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 19 | 2.666101e-18 | 0 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 70 | 1.055172e-17 | 0 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 65 | 1.976697e-17 | 0 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 49 | 2.616044e-17 | 0 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 47 | 2.619140e-17 | 0 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 59 | 2.702293e-17 | 0 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 32 | 2.760642e-17 | 0 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 32 | 2.841125e-17 | 0 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 66 | 6.196095e-17 | 0 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 47 | 7.302777e-17 | 0 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 41 | 9.617550e-17 | 0 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 49 | 1.473431e-16 | 0 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 22 | 1.729534e-16 | 0 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 40 | 1.918942e-16 | 0 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 35 | 1.974732e-16 | 0 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 36 | 3.405485e-16 | 0 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 63 | 4.632988e-16 | 0 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 53 | 9.199281e-16 | 0 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 53 | 1.501811e-15 | 0 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 53 | 1.554953e-15 | 0 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 32 | 2.455938e-15 | 0 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 49 | 2.618578e-15 | 0 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 32 | 2.641223e-15 | 0 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 44 | 2.952328e-15 | 0 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 61 | 5.541343e-15 | 0 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 42 | 8.285071e-15 | 0 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 49 | 9.455708e-15 | 0 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 49 | 1.042744e-14 | 0 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 28 | 1.260978e-14 | 0 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 24 | 1.828678e-14 | 0 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 60 | 3.407342e-14 | 0 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 49 | 3.806361e-14 | 0 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 19 | 4.288997e-14 | 0 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 19 | 1.128295e-13 | 0 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 17 | 1.348459e-13 | 0 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 43 | 1.384424e-13 | 0 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 43 | 1.626455e-13 | 0 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 17 | 1.911637e-13 | 0 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 60 | 2.153518e-13 | 0 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 28 | 2.190182e-13 | 0 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 12 | 2.295750e-13 | 0 |
| GO:BP | GO:0030162 | regulation of proteolysis | "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] | 20 | 2.352605e-13 | 0 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 44 | 2.577410e-13 | 0 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 31 | 3.351949e-13 | 0 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 28 | 3.355103e-13 | 0 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 32 | 3.550028e-13 | 0 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 32 | 3.621651e-13 | 0 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 81 | 3.768010e-13 | 0 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 15 | 7.713904e-13 | 0 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 66 | 7.965565e-13 | 0 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 45 | 9.949706e-13 | 0 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 30 | 1.135518e-12 | 0 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 30 | 1.587032e-12 | 0 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 23 | 1.702678e-12 | 0 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 27 | 1.802164e-12 | 0 |
| GO:BP | GO:0080135 | regulation of cellular response to stress | "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 21 | 1.880257e-12 | 0 |
| GO:BP | GO:2001234 | negative regulation of apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 16 | 1.964222e-12 | 0 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 47 | 3.430554e-12 | 0 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 57 | 3.894411e-12 | 0 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 33 | 4.118492e-12 | 0 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 38 | 5.227524e-12 | 0 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 24 | 6.288286e-12 | 0 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 22 | 9.456950e-12 | 0 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 22 | 1.109926e-11 | 0 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 17 | 1.152060e-11 | 0 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 21 | 1.381040e-11 | 0 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 26 | 2.863561e-11 | 0 |
| GO:BP | GO:1904356 | regulation of telomere maintenance via telomere lengthening | "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 10 | 3.136024e-11 | 0 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 80 | 3.544266e-11 | 0 |
| GO:BP | GO:0009628 | response to abiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] | 27 | 4.246491e-11 | 0 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 70 | 4.408714e-11 | 0 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 12 | 4.873092e-11 | 0 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 33 | 5.239603e-11 | 0 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 41 | 5.390247e-11 | 0 |
| GO:BP | GO:1903050 | regulation of proteolysis involved in protein catabolic process | "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 15 | 5.617190e-11 | 0 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 30 | 6.073825e-11 | 0 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 72 | 6.552745e-11 | 0 |
| GO:BP | GO:0010821 | regulation of mitochondrion organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] | 12 | 6.738906e-11 | 0 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] | 25 | 7.861581e-11 | 0 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 10 | 7.955052e-11 | 0 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 21 | 8.042597e-11 | 0 |
| GO:BP | GO:0061136 | regulation of proteasomal protein catabolic process | "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] | 14 | 9.388492e-11 | 0 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 14 | 9.388492e-11 | 0 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 10 | 1.335595e-10 | 0 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 34 | 1.411463e-10 | 0 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 45 | 1.525137e-10 | 0 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 17 | 1.798850e-10 | 0 |
| GO:BP | GO:0034605 | cellular response to heat | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] | 10 | 1.858765e-10 | 0 |
| GO:BP | GO:0007005 | mitochondrion organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] | 18 | 1.925186e-10 | 0 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 63 | 2.773029e-10 | 0 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 24 | 3.011054e-10 | 0 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 13 | 3.145870e-10 | 0 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] | 23 | 3.655148e-10 | 0 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] | 14 | 3.802774e-10 | 0 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 65 | 4.175981e-10 | 0 |
| GO:BP | GO:0009408 | response to heat | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] | 11 | 5.201077e-10 | 0 |
| GO:BP | GO:1901698 | response to nitrogen compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 25 | 7.771802e-10 | 0 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 69 | 1.179701e-09 | 0 |
| GO:BP | GO:0010629 | negative regulation of gene expression | "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 30 | 1.486115e-09 | 0 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 30 | 1.925568e-09 | 0 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 30 | 1.984751e-09 | 0 |
| GO:BP | GO:0002218 | activation of innate immune response | "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805] | 15 | 2.357999e-09 | 0 |
| GO:BP | GO:0035966 | response to topologically incorrect protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] | 12 | 2.909728e-09 | 0 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 25 | 2.999809e-09 | 0 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 28 | 3.272527e-09 | 0 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 24 | 3.314126e-09 | 0 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 20 | 3.526512e-09 | 0 |
| GO:BP | GO:0006886 | intracellular protein transport | "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] | 20 | 4.487798e-09 | 0 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 82 | 5.544798e-09 | 0 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 44 | 6.644276e-09 | 0 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 20 | 6.654369e-09 | 0 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 18 | 7.137033e-09 | 0 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 41 | 7.471814e-09 | 0 |
| GO:BP | GO:0009266 | response to temperature stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] | 12 | 7.501462e-09 | 0 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 33 | 7.707434e-09 | 0 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 18 | 8.071743e-09 | 0 |
| GO:BP | GO:0010647 | positive regulation of cell communication | "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 30 | 8.085102e-09 | 0 |
| GO:BP | GO:0023056 | positive regulation of signaling | "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 30 | 8.200308e-09 | 0 |
| GO:BP | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] | 11 | 8.668198e-09 | 0 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 15 | 8.677936e-09 | 0 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 15 | 8.677936e-09 | 0 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 18 | 8.846396e-09 | 0 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 41 | 8.984530e-09 | 0 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 22 | 1.131218e-08 | 0 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 37 | 1.656680e-08 | 0 |
| GO:BP | GO:0045727 | positive regulation of translation | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] | 11 | 1.672461e-08 | 0 |
| GO:BP | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 7 | 2.182263e-08 | 0 |
| GO:BP | GO:0032210 | regulation of telomere maintenance via telomerase | "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 8 | 2.216356e-08 | 0 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 17 | 2.327752e-08 | 0 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 26 | 2.548660e-08 | 0 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 76 | 2.565790e-08 | 0 |
| GO:BP | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 10 | 2.634488e-08 | 0 |
| GO:BP | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 10 | 2.634488e-08 | 0 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 41 | 2.819820e-08 | 0 |
| GO:BP | GO:0033044 | regulation of chromosome organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] | 13 | 2.848403e-08 | 0 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 11 | 3.100532e-08 | 0 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 72 | 3.156425e-08 | 0 |
| GO:BP | GO:0006458 | 'de novo' protein folding | "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] | 8 | 3.184619e-08 | 0 |
| GO:BP | GO:0016567 | protein ubiquitination | "The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419] | 20 | 3.463486e-08 | 0 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 24 | 4.089103e-08 | 0 |
| GO:BP | GO:0045089 | positive regulation of innate immune response | "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] | 15 | 4.326728e-08 | 0 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 28 | 4.592087e-08 | 0 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 14 | 4.879726e-08 | 0 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 28 | 4.999722e-08 | 0 |
| GO:BP | GO:0045088 | regulation of innate immune response | "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] | 16 | 5.046885e-08 | 0 |
| GO:BP | GO:0045087 | innate immune response | "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] | 22 | 5.412066e-08 | 0 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 15 | 5.416108e-08 | 0 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 23 | 7.261961e-08 | 0 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] | 27 | 8.189371e-08 | 0 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] | 24 | 8.301053e-08 | 0 |
| GO:BP | GO:0007165 | signal transduction | "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] | 53 | 9.566940e-08 | 0 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 37 | 1.076379e-07 | 0 |
| GO:BP | GO:0002833 | positive regulation of response to biotic stimulus | "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] | 15 | 1.113991e-07 | 0 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 34 | 1.253456e-07 | 0 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 63 | 1.343048e-07 | 0 |
| GO:BP | GO:0002253 | activation of immune response | "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] | 17 | 1.369431e-07 | 0 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 24 | 1.438334e-07 | 0 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 28 | 1.714767e-07 | 0 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 62 | 1.749681e-07 | 0 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 15 | 1.802823e-07 | 0 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 11 | 1.837086e-07 | 0 |
| GO:BP | GO:0034097 | response to cytokine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] | 21 | 1.959023e-07 | 0 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 55 | 2.052109e-07 | 0 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 76 | 2.115673e-07 | 0 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 29 | 2.219450e-07 | 0 |
| GO:BP | GO:0071345 | cellular response to cytokine stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah] | 20 | 2.293821e-07 | 0 |
| GO:BP | GO:0016032 | viral process | "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah] | 15 | 2.433575e-07 | 0 |
| GO:BP | GO:1901652 | response to peptide | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] | 21 | 2.615259e-07 | 0 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 13 | 2.835397e-07 | 0 |
| GO:BP | GO:0031349 | positive regulation of defense response | "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah] | 16 | 2.952268e-07 | 0 |
| GO:BP | GO:0140546 | defense response to symbiont | "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] | 22 | 3.345904e-07 | 0 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 14 | 3.358085e-07 | 0 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 50 | 3.375994e-07 | 0 |
| GO:BP | GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 10 | 3.513910e-07 | 0 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 22 | 3.652488e-07 | 0 |
| GO:BP | GO:0006914 | autophagy | "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464] | 17 | 3.682459e-07 | 0 |
| GO:BP | GO:0061919 | process utilizing autophagic mechanism | "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] | 17 | 3.682459e-07 | 0 |
| GO:BP | GO:0006986 | response to unfolded protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] | 10 | 4.681719e-07 | 0 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 34 | 4.948952e-07 | 0 |
| GO:BP | GO:0048511 | rhythmic process | "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] | 13 | 5.059940e-07 | 0 |
| GO:BP | GO:0034599 | cellular response to oxidative stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] | 12 | 5.893001e-07 | 0 |
| GO:BP | GO:1903312 | negative regulation of mRNA metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 9 | 5.893751e-07 | 0 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 20 | 6.609150e-07 | 0 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 16 | 6.668474e-07 | 0 |
| GO:BP | GO:0031347 | regulation of defense response | "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] | 19 | 6.954197e-07 | 0 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 29 | 7.290801e-07 | 0 |
| GO:BP | GO:0051084 | 'de novo' post-translational protein folding | "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] | 7 | 7.522406e-07 | 0 |
| GO:BP | GO:0002831 | regulation of response to biotic stimulus | "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] | 16 | 7.635624e-07 | 0 |
| GO:BP | GO:0062197 | cellular response to chemical stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] | 13 | 8.125091e-07 | 0 |
| GO:BP | GO:1901796 | regulation of signal transduction by p53 class mediator | "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 9 | 8.341990e-07 | 0 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 32 | 8.370465e-07 | 0 |
| GO:BP | GO:0032212 | positive regulation of telomere maintenance via telomerase | "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 6 | 8.975028e-07 | 0 |
| GO:BP | GO:0051131 | chaperone-mediated protein complex assembly | "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai] | 6 | 8.975028e-07 | 0 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 18 | 9.465977e-07 | 0 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] | 17 | 1.018941e-06 | 0 |
| GO:BP | GO:0009607 | response to biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] | 26 | 1.023515e-06 | 0 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 8 | 1.169809e-06 | 0 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 17 | 1.203269e-06 | 0 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 8 | 1.305278e-06 | 0 |
| GO:BP | GO:0002221 | pattern recognition receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] | 12 | 1.436785e-06 | 0 |
| GO:BP | GO:1901800 | positive regulation of proteasomal protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] | 9 | 1.482769e-06 | 0 |
| GO:BP | GO:0007623 | circadian rhythm | "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] | 11 | 1.552390e-06 | 0 |
| GO:BP | GO:0042752 | regulation of circadian rhythm | "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] | 9 | 1.604688e-06 | 0 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 12 | 1.631913e-06 | 0 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 76 | 1.735084e-06 | 0 |
| GO:BP | GO:0042026 | protein refolding | "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] | 6 | 1.955066e-06 | 0 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 15 | 1.960460e-06 | 0 |
| GO:BP | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] | 8 | 2.206889e-06 | 0 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 15 | 2.377926e-06 | 0 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 11 | 2.419853e-06 | 0 |
| GO:BP | GO:0009605 | response to external stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] | 31 | 2.559799e-06 | 0 |
| GO:BP | GO:0045595 | regulation of cell differentiation | "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] | 25 | 2.610388e-06 | 0 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 53 | 2.653862e-06 | 0 |
| GO:BP | GO:0002758 | innate immune response-activating signaling pathway | "The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an innate immune response." [GOC:jy, GOC:mah, PMID:11418339, PMID:28105028] | 12 | 2.898354e-06 | 0 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 53 | 3.089957e-06 | 0 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 21 | 3.669430e-06 | 0 |
| GO:BP | GO:0002753 | cytoplasmic pattern recognition receptor signaling pathway | "The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967, PMID:17328678, PMID:18272355, PMID:19531363, PMID:21187438] | 10 | 3.941036e-06 | 0 |
| GO:BP | GO:0006109 | regulation of carbohydrate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] | 10 | 4.166472e-06 | 0 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 20 | 4.329638e-06 | 0 |
| GO:BP | GO:0098542 | defense response to other organism | "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] | 22 | 6.068669e-06 | 0 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 50 | 6.086670e-06 | 0 |
| GO:BP | GO:0070848 | response to growth factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah] | 17 | 6.466346e-06 | 0 |
| GO:BP | GO:0030522 | intracellular receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a receptor located within a cell." [GOC:bf, GOC:mah] | 13 | 6.657295e-06 | 0 |
| GO:BP | GO:0006006 | glucose metabolic process | "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] | 10 | 6.771185e-06 | 0 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 8 | 6.817892e-06 | 0 |
| GO:BP | GO:2000767 | positive regulation of cytoplasmic translation | "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 5 | 7.929208e-06 | 0 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488] | 12 | 8.073309e-06 | 0 |
| GO:BP | GO:1900182 | positive regulation of protein localization to nucleus | "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 8 | 8.817652e-06 | 0 |
| GO:BP | GO:0032103 | positive regulation of response to external stimulus | "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] | 16 | 9.182361e-06 | 0 |
| GO:BP | GO:0043255 | regulation of carbohydrate biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl] | 8 | 9.588335e-06 | 0 |
| GO:BP | GO:0016051 | carbohydrate biosynthetic process | "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 10 | 1.020726e-05 | 0 |
| GO:BP | GO:0062012 | regulation of small molecule metabolic process | "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] | 12 | 1.111506e-05 | 0 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] | 11 | 1.192958e-05 | 0 |
| GO:BP | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 8 | 1.226048e-05 | 0 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 53 | 1.289789e-05 | 0 |
| GO:BP | GO:0006979 | response to oxidative stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] | 13 | 1.352735e-05 | 0 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] | 20 | 1.374691e-05 | 0 |
| GO:BP | GO:0050778 | positive regulation of immune response | "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 17 | 1.417314e-05 | 0 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] | 12 | 1.621252e-05 | 0 |
| GO:BP | GO:0051707 | response to other organism | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] | 24 | 1.676371e-05 | 0 |
| GO:BP | GO:0008637 | apoptotic mitochondrial changes | "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis] | 8 | 1.680934e-05 | 0 |
| GO:BP | GO:0043207 | response to external biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] | 24 | 1.739071e-05 | 0 |
| GO:BP | GO:0002757 | immune response-activating signaling pathway | "The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add] | 14 | 1.910774e-05 | 0 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 8 | 1.958546e-05 | 0 |
| GO:BP | GO:0045732 | positive regulation of protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] | 10 | 2.302346e-05 | 0 |
| GO:BP | GO:2001236 | regulation of extrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 9 | 2.577602e-05 | 0 |
| GO:BP | GO:0035967 | cellular response to topologically incorrect protein | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] | 8 | 2.634497e-05 | 0 |
| GO:BP | GO:0031400 | negative regulation of protein modification process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 12 | 2.920335e-05 | 0 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 12 | 3.210664e-05 | 0 |
| GO:BP | GO:0048869 | cellular developmental process | "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] | 41 | 3.243788e-05 | 0 |
| GO:BP | GO:0045184 | establishment of protein localization | "The directed movement of a protein to a specific location." [GOC:bf] | 26 | 3.687392e-05 | 0 |
| GO:BP | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] | 6 | 3.826590e-05 | 0 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 9 | 3.986268e-05 | 0 |
| GO:BP | GO:0006606 | protein import into nucleus | "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] | 9 | 4.429311e-05 | 0 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 10 | 4.453354e-05 | 0 |
| GO:BP | GO:0019318 | hexose metabolic process | "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] | 10 | 4.844980e-05 | 0 |
| GO:BP | GO:0010506 | regulation of autophagy | "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] | 12 | 5.089444e-05 | 0 |
| GO:BP | GO:0039531 | regulation of cytoplasmic pattern recognition receptor signaling pathway | "Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway." [GOC:bf, GOC:jl] | 8 | 5.266071e-05 | 0 |
| GO:BP | GO:0051170 | import into nucleus | "The directed movement of substances into the nucleus." [GOC:ai] | 9 | 5.730376e-05 | 0 |
| GO:BP | GO:0002764 | immune response-regulating signaling pathway | "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] | 14 | 5.839112e-05 | 0 |
| GO:BP | GO:0050776 | regulation of immune response | "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 18 | 5.902764e-05 | 0 |
| GO:BP | GO:0062207 | regulation of pattern recognition receptor signaling pathway | "Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168] | 9 | 6.027328e-05 | 0 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 53 | 6.609450e-05 | 0 |
| GO:BP | GO:0016055 | Wnt signaling pathway | "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397] | 13 | 6.707845e-05 | 0 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 18 | 6.817403e-05 | 0 |
| GO:BP | GO:0006952 | defense response | "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] | 25 | 6.882312e-05 | 0 |
| GO:BP | GO:0015031 | protein transport | "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 22 | 6.892009e-05 | 0 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 18 | 6.926701e-05 | 0 |
| GO:BP | GO:0006839 | mitochondrial transport | "Transport of substances into, out of or within a mitochondrion." [GOC:ai] | 9 | 8.108135e-05 | 0 |
| GO:BP | GO:0019058 | viral life cycle | "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272] | 11 | 8.914869e-05 | 0 |
| GO:BP | GO:0070841 | inclusion body assembly | "The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah] | 5 | 9.376394e-05 | 0 |
| GO:BP | GO:0005975 | carbohydrate metabolic process | "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] | 14 | 9.381038e-05 | 0 |
| GO:BP | GO:0051094 | positive regulation of developmental process | "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 21 | 9.811834e-05 | 0 |
| GO:BP | GO:0072594 | establishment of protein localization to organelle | "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] | 15 | 1.022533e-04 | 0 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] | 11 | 1.049148e-04 | 0 |
| GO:BP | GO:2000573 | positive regulation of DNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 6 | 1.101992e-04 | 0 |
| GO:BP | GO:0019079 | viral genome replication | "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534] | 8 | 1.117520e-04 | 0 |
| GO:BP | GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 8 | 1.117520e-04 | 0 |
| GO:BP | GO:0030154 | cell differentiation | "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] | 40 | 1.149636e-04 | 0 |
| GO:BP | GO:1901875 | positive regulation of post-translational protein modification | "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 8 | 1.185794e-04 | 0 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 17 | 1.190773e-04 | 0 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 15 | 1.220166e-04 | 0 |
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 9 | 1.240183e-04 | 0 |
| GO:BP | GO:0010332 | response to gamma radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators] | 6 | 1.241773e-04 | 0 |
| GO:BP | GO:0005996 | monosaccharide metabolic process | "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732] | 10 | 1.254887e-04 | 0 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 22 | 1.291656e-04 | 0 |
| GO:BP | GO:0016049 | cell growth | "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] | 13 | 1.308781e-04 | 0 |
| GO:BP | GO:0009205 | purine ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 1.403358e-04 | 0 |
| GO:BP | GO:0071705 | nitrogen compound transport | "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] | 25 | 1.425490e-04 | 0 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 17 | 1.471175e-04 | 0 |
| GO:BP | GO:0070934 | CRD-mediated mRNA stabilization | "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] | 4 | 1.594995e-04 | 0 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | "The alteration of an amino acid residue in a peptide." [GOC:mah] | 15 | 1.659191e-04 | 0 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah] | 15 | 1.755959e-04 | 0 |
| GO:BP | GO:0009199 | ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 1.811534e-04 | 0 |
| GO:BP | GO:0009144 | purine nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 1.811534e-04 | 0 |
| GO:BP | GO:0006402 | mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 10 | 1.877655e-04 | 0 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 41 | 2.108630e-04 | 0 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] | 12 | 2.276789e-04 | 0 |
| GO:BP | GO:0010906 | regulation of glucose metabolic process | "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] | 7 | 2.347299e-04 | 0 |
| GO:BP | GO:1900152 | negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] | 4 | 2.385213e-04 | 0 |
| GO:BP | GO:0033993 | response to lipid | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] | 17 | 2.673460e-04 | 0 |
| GO:BP | GO:0045861 | negative regulation of proteolysis | "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] | 8 | 2.733600e-04 | 0 |
| GO:BP | GO:0034614 | cellular response to reactive oxygen species | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] | 8 | 2.733600e-04 | 0 |
| GO:BP | GO:0071396 | cellular response to lipid | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] | 14 | 2.791140e-04 | 0 |
| GO:BP | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:ai, GOC:mtg_apoptosis] | 6 | 2.976914e-04 | 0 |
| GO:BP | GO:0010038 | response to metal ion | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] | 11 | 3.130149e-04 | 0 |
| GO:BP | GO:0009141 | nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 3.158663e-04 | 0 |
| GO:BP | GO:0002682 | regulation of immune system process | "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] | 22 | 3.403355e-04 | 0 |
| GO:BP | GO:1902253 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871] | 5 | 3.476794e-04 | 0 |
| GO:BP | GO:0062098 | regulation of programmed necrotic cell death | "Any process that modulates the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785] | 5 | 3.476794e-04 | 0 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 30 | 3.977266e-04 | 0 |
| GO:BP | GO:0016236 | macroautophagy | "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339] | 11 | 4.263356e-04 | 0 |
| GO:BP | GO:0010586 | miRNA metabolic process | "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] | 7 | 4.647813e-04 | 0 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] | 18 | 4.743515e-04 | 0 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 6 | 4.834023e-04 | 0 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 13 | 5.120378e-04 | 0 |
| GO:BP | GO:0031398 | positive regulation of protein ubiquitination | "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 7 | 5.283833e-04 | 0 |
| GO:BP | GO:0043086 | negative regulation of catalytic activity | "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] | 10 | 5.489394e-04 | 0 |
| GO:BP | GO:0002684 | positive regulation of immune system process | "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] | 18 | 5.502498e-04 | 0 |
| GO:BP | GO:0044092 | negative regulation of molecular function | "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 13 | 5.920159e-04 | 0 |
| GO:BP | GO:0002376 | immune system process | "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] | 30 | 5.957425e-04 | 0 |
| GO:BP | GO:0032885 | regulation of polysaccharide biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah] | 5 | 6.427796e-04 | 0 |
| GO:BP | GO:0048024 | regulation of mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 7 | 6.777632e-04 | 0 |
| GO:BP | GO:0048255 | mRNA stabilization | "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid] | 6 | 6.927026e-04 | 0 |
| GO:BP | GO:0046034 | ATP metabolic process | "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] | 9 | 6.957014e-04 | 0 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] | 9 | 7.217035e-04 | 0 |
| GO:BP | GO:2000765 | regulation of cytoplasmic translation | "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 5 | 7.408900e-04 | 0 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 27 | 7.416988e-04 | 0 |
| GO:BP | GO:0006325 | chromatin organization | "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] | 16 | 7.577793e-04 | 0 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 27 | 7.605473e-04 | 0 |
| GO:BP | GO:0032501 | multicellular organismal process | "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] | 52 | 7.618830e-04 | 0 |
| GO:BP | GO:0000423 | mitophagy | "The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367] | 6 | 8.223325e-04 | 0 |
| GO:BP | GO:0001649 | osteoblast differentiation | "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid] | 9 | 8.343408e-04 | 0 |
| GO:BP | GO:0007006 | mitochondrial membrane organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 7 | 8.612045e-04 | 0 |
| GO:BP | GO:0007249 | canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217] | 10 | 8.683592e-04 | 0 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] | 8 | 9.956155e-04 | 0 |
| GO:BP | GO:0006401 | RNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 10 | 1.066468e-03 | 0 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 19 | 1.088702e-03 | 0 |
| GO:BP | GO:0070266 | necroptotic process | "A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former." [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153] | 5 | 1.107952e-03 | 0 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] | 30 | 1.128061e-03 | 0 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 10 | 1.196599e-03 | 0 |
| GO:BP | GO:0038061 | non-canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217] | 7 | 1.213604e-03 | 0 |
| GO:BP | GO:0090666 | scaRNA localization to Cajal body | "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 3 | 1.274115e-03 | 0 |
| GO:BP | GO:0072655 | establishment of protein localization to mitochondrion | "The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah] | 7 | 1.282718e-03 | 0 |
| GO:BP | GO:0001558 | regulation of cell growth | "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] | 11 | 1.329366e-03 | 0 |
| GO:BP | GO:0061614 | miRNA transcription | "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] | 6 | 1.335613e-03 | 0 |
| GO:BP | GO:0043488 | regulation of mRNA stability | "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] | 8 | 1.343137e-03 | 0 |
| GO:BP | GO:0031669 | cellular response to nutrient levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 9 | 1.357477e-03 | 0 |
| GO:BP | GO:0051093 | negative regulation of developmental process | "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 16 | 1.384516e-03 | 0 |
| GO:BP | GO:0043489 | RNA stabilization | "Prevention of degradation of RNA molecules." [GOC:go_curators] | 6 | 1.442321e-03 | 0 |
| GO:BP | GO:0016241 | regulation of macroautophagy | "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] | 8 | 1.521130e-03 | 0 |
| GO:BP | GO:1902373 | negative regulation of mRNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865] | 6 | 1.555913e-03 | 0 |
| GO:BP | GO:0018209 | peptidyl-serine modification | "The modification of peptidyl-serine." [GOC:go_curators] | 8 | 1.650674e-03 | 0 |
| GO:BP | GO:0031667 | response to nutrient levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 12 | 1.758469e-03 | 0 |
| GO:BP | GO:0032881 | regulation of polysaccharide metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah] | 5 | 1.805859e-03 | 0 |
| GO:BP | GO:0070585 | protein localization to mitochondrion | "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd] | 7 | 2.067831e-03 | 0 |
| GO:BP | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] | 6 | 2.086084e-03 | 0 |
| GO:BP | GO:0048545 | response to steroid hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators] | 10 | 2.134592e-03 | 0 |
| GO:BP | GO:0043487 | regulation of RNA stability | "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] | 8 | 2.181046e-03 | 0 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 13 | 2.186265e-03 | 0 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 29 | 2.187466e-03 | 0 |
| GO:BP | GO:1900542 | regulation of purine nucleotide metabolic process | "Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] | 6 | 2.239421e-03 | 0 |
| GO:BP | GO:1905710 | positive regulation of membrane permeability | "Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane." [PMID:27482894] | 5 | 2.265120e-03 | 0 |
| GO:BP | GO:1903376 | regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] | 4 | 2.278416e-03 | 0 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] | 28 | 2.287556e-03 | 0 |
| GO:BP | GO:0050684 | regulation of mRNA processing | "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] | 7 | 2.288297e-03 | 0 |
| GO:BP | GO:0141188 | nucleic acid catabolic process | "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators] | 10 | 2.310906e-03 | 0 |
| GO:BP | GO:0006163 | purine nucleotide metabolic process | "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 11 | 2.332654e-03 | 0 |
| GO:BP | GO:0006140 | regulation of nucleotide metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] | 6 | 2.401856e-03 | 0 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 49 | 2.414573e-03 | 0 |
| GO:BP | GO:0043467 | regulation of generation of precursor metabolites and energy | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl] | 7 | 2.528138e-03 | 0 |
| GO:BP | GO:0070842 | aggresome assembly | "The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein." [GOC:BHF, GOC:rl, PMID:14675537] | 3 | 2.540868e-03 | 0 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 10 | 2.565717e-03 | 0 |
| GO:BP | GO:1905897 | regulation of response to endoplasmic reticulum stress | "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] | 6 | 2.573800e-03 | 0 |
| GO:BP | GO:0061013 | regulation of mRNA catabolic process | "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 8 | 2.643445e-03 | 0 |
| GO:BP | GO:0000302 | response to reactive oxygen species | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] | 8 | 2.745313e-03 | 0 |
| GO:BP | GO:0009150 | purine ribonucleotide metabolic process | "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 2.844740e-03 | 0 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 13 | 2.900861e-03 | 0 |
| GO:BP | GO:0043434 | response to peptide hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] | 11 | 2.917410e-03 | 0 |
| GO:BP | GO:0031334 | positive regulation of protein-containing complex assembly | "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] | 8 | 2.959124e-03 | 0 |
| GO:BP | GO:0070201 | regulation of establishment of protein localization | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] | 12 | 3.014897e-03 | 0 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 8 | 3.071247e-03 | 0 |
| GO:BP | GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | "Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 6 | 3.365356e-03 | 0 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 6 | 3.365356e-03 | 0 |
| GO:BP | GO:0036480 | neuron intrinsic apoptotic signaling pathway in response to oxidative stress | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:PARL, PMID:23858059] | 4 | 3.419078e-03 | 0 |
| GO:BP | GO:1902369 | negative regulation of RNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] | 6 | 3.591477e-03 | 0 |
| GO:BP | GO:0032869 | cellular response to insulin stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 8 | 3.687795e-03 | 0 |
| GO:BP | GO:1903313 | positive regulation of mRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 7 | 3.709137e-03 | 0 |
| GO:BP | GO:0030177 | positive regulation of Wnt signaling pathway | "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] | 7 | 3.709137e-03 | 0 |
| GO:BP | GO:0007017 | microtubule-based process | "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] | 16 | 3.794841e-03 | 0 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 35 | 4.007280e-03 | 0 |
| GO:BP | GO:0032006 | regulation of TOR signaling | "Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah] | 7 | 4.067387e-03 | 0 |
| GO:BP | GO:0044093 | positive regulation of molecular function | "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 15 | 4.124666e-03 | 0 |
| GO:BP | GO:1900151 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] | 4 | 4.126303e-03 | 0 |
| GO:BP | GO:0097300 | programmed necrotic cell death | "A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:mtg_apoptosis, PMID:21760595] | 5 | 4.214789e-03 | 0 |
| GO:BP | GO:0031648 | protein destabilization | "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah] | 5 | 4.214789e-03 | 0 |
| GO:BP | GO:0034620 | cellular response to unfolded protein | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah] | 6 | 4.345407e-03 | 0 |
| GO:BP | GO:1901874 | negative regulation of post-translational protein modification | "Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 6 | 4.345407e-03 | 0 |
| GO:BP | GO:0045912 | negative regulation of carbohydrate metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] | 5 | 4.639290e-03 | 0 |
| GO:BP | GO:0009259 | ribonucleotide metabolic process | "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 4.788675e-03 | 0 |
| GO:BP | GO:1903828 | negative regulation of protein localization | "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 8 | 4.892900e-03 | 0 |
| GO:BP | GO:0000271 | polysaccharide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] | 5 | 5.588871e-03 | 0 |
| GO:BP | GO:0019693 | ribose phosphate metabolic process | "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 10 | 5.788299e-03 | 0 |
| GO:BP | GO:0039532 | negative regulation of cytoplasmic pattern recognition receptor signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway." [GOC:bf, GOC:jl] | 5 | 6.117629e-03 | 0 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 23 | 6.262993e-03 | 0 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 5 | 6.684916e-03 | 0 |
| GO:BP | GO:2000737 | negative regulation of stem cell differentiation | "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol] | 4 | 6.903165e-03 | 0 |
| GO:BP | GO:0051086 | chaperone mediated protein folding independent of cofactor | "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] | 3 | 7.073396e-03 | 0 |
| GO:BP | GO:0045936 | negative regulation of phosphate metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 9 | 7.277616e-03 | 0 |
| GO:BP | GO:0010563 | negative regulation of phosphorus metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 9 | 7.277616e-03 | 0 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 15 | 7.477502e-03 | 0 |
| GO:BP | GO:0040007 | growth | "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] | 15 | 7.576163e-03 | 0 |
| GO:BP | GO:1901654 | response to ketone | "A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676] | 8 | 7.811028e-03 | 0 |
| GO:BP | GO:0034612 | response to tumor necrosis factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] | 8 | 7.811028e-03 | 0 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 8 | 8.066499e-03 | 0 |
| GO:BP | GO:0060544 | regulation of necroptotic process | "Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 4 | 8.079092e-03 | 0 |
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 7 | 8.119481e-03 | 0 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 7 | 8.119481e-03 | 0 |
| GO:BP | GO:0000422 | autophagy of mitochondrion | "The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344] | 6 | 8.293904e-03 | 0 |
| GO:BP | GO:0050807 | regulation of synapse organization | "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] | 9 | 8.309983e-03 | 0 |
| GO:BP | GO:0051656 | establishment of organelle localization | "The directed movement of an organelle to a specific location." [GOC:ai] | 11 | 8.382960e-03 | 0 |
| GO:BP | GO:0006955 | immune response | "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add] | 23 | 8.568802e-03 | 0 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 39 | 8.595577e-03 | 0 |
| GO:BP | GO:0009117 | nucleotide metabolic process | "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] | 11 | 8.714096e-03 | 0 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 29 | 9.228834e-03 | 0 |
| GO:BP | GO:0090263 | positive regulation of canonical Wnt signaling pathway | "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] | 6 | 9.254816e-03 | 0 |
| GO:BP | GO:0062014 | negative regulation of small molecule metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] | 6 | 9.254816e-03 | 0 |
| GO:BP | GO:0031929 | TOR signaling | "The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295] | 7 | 9.924552e-03 | 0 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] | 9 | 9.965464e-03 | 0 |
| GO:BP | GO:0040008 | regulation of growth | "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] | 12 | 1.010853e-02 | 0 |
| GO:BP | GO:0006611 | protein export from nucleus | "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] | 5 | 1.017094e-02 | 0 |
| GO:BP | GO:1903317 | regulation of protein maturation | "Any process that modulates the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 5 | 1.017094e-02 | 0 |
| GO:BP | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 3 | 1.057946e-02 | 0 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 7 | 1.073452e-02 | 0 |
| GO:BP | GO:0090140 | regulation of mitochondrial fission | "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] | 4 | 1.086737e-02 | 0 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] | 8 | 1.103631e-02 | 0 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 13 | 1.109235e-02 | 0 |
| GO:BP | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] | 4 | 1.250118e-02 | 0 |
| GO:BP | GO:0016052 | carbohydrate catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 7 | 1.252023e-02 | 0 |
| GO:BP | GO:0060284 | regulation of cell development | "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] | 14 | 1.278678e-02 | 0 |
| GO:BP | GO:0046824 | positive regulation of nucleocytoplasmic transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] | 5 | 1.286142e-02 | 0 |
| GO:BP | GO:0002683 | negative regulation of immune system process | "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] | 11 | 1.318666e-02 | 0 |
| GO:BP | GO:0051085 | chaperone cofactor-dependent protein refolding | "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb] | 4 | 1.430962e-02 | 0 |
| GO:BP | GO:0046822 | regulation of nucleocytoplasmic transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] | 6 | 1.476667e-02 | 0 |
| GO:BP | GO:1904871 | positive regulation of protein localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 3 | 1.506988e-02 | 0 |
| GO:BP | GO:1904869 | regulation of protein localization to Cajal body | "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 3 | 1.506988e-02 | 0 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 19 | 1.507600e-02 | 0 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 13 | 1.601708e-02 | 0 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 11 | 1.668057e-02 | 0 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 10 | 1.719807e-02 | 0 |
| GO:BP | GO:0090559 | regulation of membrane permeability | "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane." [GOC:kmv, PMID:22677064] | 5 | 1.728192e-02 | 0 |
| GO:BP | GO:0022607 | cellular component assembly | "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] | 37 | 1.809804e-02 | 0 |
| GO:BP | GO:0009314 | response to radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] | 10 | 1.979457e-02 | 0 |
| GO:BP | GO:0000380 | alternative mRNA splicing, via spliceosome | "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] | 5 | 1.989645e-02 | 0 |
| GO:BP | GO:0006983 | ER overload response | "The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516] | 3 | 2.066127e-02 | 0 |
| GO:BP | GO:0043516 | regulation of DNA damage response, signal transduction by p53 class mediator | "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] | 4 | 2.089926e-02 | 0 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 46 | 2.126374e-02 | 0 |
| GO:BP | GO:0051881 | regulation of mitochondrial membrane potential | "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai] | 5 | 2.131452e-02 | 0 |
| GO:BP | GO:0000724 | double-strand break repair via homologous recombination | "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] | 7 | 2.156916e-02 | 0 |
| GO:BP | GO:0032386 | regulation of intracellular transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] | 8 | 2.338281e-02 | 0 |
| GO:BP | GO:0032886 | regulation of microtubule-based process | "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] | 8 | 2.338281e-02 | 0 |
| GO:BP | GO:1903578 | regulation of ATP metabolic process | "Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] | 5 | 2.438693e-02 | 0 |
| GO:BP | GO:0071248 | cellular response to metal ion | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah] | 7 | 2.473468e-02 | 0 |
| GO:BP | GO:0000725 | recombinational repair | "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] | 7 | 2.558347e-02 | 0 |
| GO:BP | GO:0032868 | response to insulin | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 8 | 2.605271e-02 | 0 |
| GO:BP | GO:0016242 | negative regulation of macroautophagy | "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] | 4 | 2.638448e-02 | 0 |
| GO:BP | GO:0046825 | regulation of protein export from nucleus | "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf] | 4 | 2.638448e-02 | 0 |
| GO:BP | GO:1903405 | protein localization to nuclear body | "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] | 3 | 2.746886e-02 | 0 |
| GO:BP | GO:1904867 | protein localization to Cajal body | "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 3 | 2.746886e-02 | 0 |
| GO:BP | GO:1904872 | regulation of telomerase RNA localization to Cajal body | "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 3 | 2.746886e-02 | 0 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 5 | 2.779463e-02 | 0 |
| GO:BP | GO:0050808 | synapse organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] | 11 | 3.038992e-02 | 0 |
| GO:BP | GO:0072521 | purine-containing compound metabolic process | "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 11 | 3.038992e-02 | 0 |
| GO:BP | GO:0070925 | organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 15 | 3.136145e-02 | 0 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 17 | 3.170142e-02 | 0 |
| GO:BP | GO:0006403 | RNA localization | "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] | 7 | 3.222716e-02 | 0 |
| GO:BP | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15790595] | 3 | 3.560647e-02 | 0 |
| GO:BP | GO:0031571 | mitotic G1 DNA damage checkpoint signaling | "A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle] | 3 | 3.560647e-02 | 0 |
| GO:BP | GO:2000736 | regulation of stem cell differentiation | "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol] | 5 | 3.571794e-02 | 0 |
| GO:BP | GO:0045913 | positive regulation of carbohydrate metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] | 5 | 3.571794e-02 | 0 |
| GO:BP | GO:0050679 | positive regulation of epithelial cell proliferation | "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai] | 7 | 3.662463e-02 | 0 |
| GO:BP | GO:0007399 | nervous system development | "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] | 25 | 3.840241e-02 | 0 |
| GO:BP | GO:0001763 | morphogenesis of a branching structure | "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] | 7 | 3.900266e-02 | 0 |
| GO:BP | GO:0090199 | regulation of release of cytochrome c from mitochondria | "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 4 | 4.044028e-02 | 0 |
| GO:BP | GO:0043122 | regulation of canonical NF-kappaB signal transduction | "Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372] | 8 | 4.045338e-02 | 0 |
| GO:BP | GO:0071356 | cellular response to tumor necrosis factor | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] | 7 | 4.150689e-02 | 0 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] | 7 | 4.150689e-02 | 0 |
| GO:BP | GO:0006289 | nucleotide-excision repair | "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] | 5 | 4.273599e-02 | 0 |
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] | 10 | 4.290183e-02 | 0 |
| GO:BP | GO:0032388 | positive regulation of intracellular transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] | 6 | 4.326392e-02 | 0 |
| GO:BP | GO:0000266 | mitochondrial fission | "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] | 4 | 4.467621e-02 | 0 |
| GO:BP | GO:0010212 | response to ionizing radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] | 6 | 4.504358e-02 | 0 |
| GO:BP | GO:0160049 | negative regulation of cGAS/STING signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of cGAS/STING signaling pathway." [PMID:29875158] | 3 | 4.518657e-02 | 0 |
| GO:BP | GO:1990173 | protein localization to nucleoplasm | "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] | 3 | 4.518657e-02 | 0 |
| GO:BP | GO:0044819 | mitotic G1/S transition checkpoint signaling | "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 4.518657e-02 | 0 |
| GO:BP | GO:0031333 | negative regulation of protein-containing complex assembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] | 6 | 4.688179e-02 | 0 |
| GO:BP | GO:0071383 | cellular response to steroid hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah] | 7 | 4.835388e-02 | 0 |
| GO:BP | GO:0035794 | positive regulation of mitochondrial membrane permeability | "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf, PMID:12546810] | 4 | 4.922914e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 61 | 2.695445e-23 | 0 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 72 | 7.082702e-23 | 0 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 72 | 7.082702e-23 | 0 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 72 | 7.082702e-23 | 0 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 65 | 8.626933e-21 | 0 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 64 | 8.685267e-20 | 0 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 68 | 7.347212e-19 | 0 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 68 | 7.414921e-19 | 0 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 40 | 1.249983e-16 | 0 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 40 | 2.069597e-16 | 0 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 40 | 2.104380e-16 | 0 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 40 | 2.104380e-16 | 0 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 76 | 5.375947e-15 | 0 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 34 | 4.655703e-12 | 0 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 47 | 5.529200e-12 | 0 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 64 | 4.452683e-11 | 0 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 35 | 1.549469e-10 | 0 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 22 | 5.810078e-10 | 0 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 40 | 6.641148e-10 | 0 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 77 | 1.757154e-09 | 0 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 82 | 3.380853e-09 | 0 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 13 | 5.815842e-09 | 0 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 13 | 1.412429e-08 | 0 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 25 | 2.943760e-08 | 0 |
| GO:CC | GO:0098978 | glutamatergic synapse | "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] | 17 | 3.419423e-08 | 0 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 83 | 5.491779e-08 | 0 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 26 | 9.955399e-08 | 0 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 42 | 1.048384e-07 | 0 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 83 | 3.320646e-07 | 0 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 9 | 3.578472e-07 | 0 |
| GO:CC | GO:0016363 | nuclear matrix | "A dynamic, proteinaceous framework within the nucleus of eukaryotic cells, composed of proteins and RNA, that provides structural support for chromatin organization, gene regulation, and nuclear processes." [PMID:15608168, PMID:3058729, PMID:39789220] | 9 | 5.088640e-07 | 0 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 31 | 5.996984e-07 | 0 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 31 | 6.350503e-07 | 0 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 84 | 9.947919e-07 | 0 |
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 10 | 2.463836e-06 | 0 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 14 | 3.558644e-06 | 0 |
| GO:CC | GO:0016234 | inclusion body | "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744] | 7 | 3.906017e-06 | 0 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 22 | 4.620416e-06 | 0 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 18 | 4.750568e-06 | 0 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 85 | 5.023901e-06 | 0 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 30 | 7.795920e-06 | 0 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 9 | 1.143658e-05 | 0 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 11 | 1.349389e-05 | 0 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 11 | 1.577507e-05 | 0 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 21 | 1.601988e-05 | 0 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 11 | 1.627045e-05 | 0 |
| GO:CC | GO:0071013 | catalytic step 2 spliceosome | "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 7 | 1.835558e-05 | 0 |
| GO:CC | GO:0010494 | cytoplasmic stress granule | "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] | 7 | 2.135219e-05 | 0 |
| GO:CC | GO:0035861 | site of double-strand break | "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] | 7 | 3.070362e-05 | 0 |
| GO:CC | GO:0016235 | aggresome | "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744] | 5 | 6.762242e-05 | 0 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 7 | 8.692333e-05 | 0 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 7 | 8.692333e-05 | 0 |
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 23 | 8.713346e-05 | 0 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 27 | 8.787269e-05 | 0 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 11 | 1.275202e-04 | 0 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 5 | 1.533090e-04 | 0 |
| GO:CC | GO:0016607 | nuclear speck | "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640] | 11 | 1.827075e-04 | 0 |
| GO:CC | GO:0090734 | site of DNA damage | "A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg] | 7 | 2.016016e-04 | 0 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 11 | 2.150117e-04 | 0 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 17 | 2.389152e-04 | 0 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 39 | 2.635775e-04 | 0 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 11 | 2.698906e-04 | 0 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 15 | 5.177275e-04 | 0 |
| GO:CC | GO:0044297 | cell body | "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] | 12 | 5.325194e-04 | 0 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 15 | 5.540863e-04 | 0 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 16 | 8.041420e-04 | 0 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 11 | 8.700698e-04 | 0 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 16 | 8.851415e-04 | 0 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 25 | 9.123202e-04 | 0 |
| GO:CC | GO:0002199 | zona pellucida receptor complex | "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] | 3 | 9.297774e-04 | 0 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 7 | 1.327437e-03 | 0 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 59 | 1.328771e-03 | 0 |
| GO:CC | GO:0048471 | perinuclear region of cytoplasm | "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] | 13 | 1.577953e-03 | 0 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 8 | 1.968026e-03 | 0 |
| GO:CC | GO:0005832 | chaperonin-containing T-complex | "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] | 3 | 1.981339e-03 | 0 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 13 | 2.513564e-03 | 0 |
| GO:CC | GO:0008180 | COP9 signalosome | "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] | 4 | 2.980874e-03 | 0 |
| GO:CC | GO:0031967 | organelle envelope | "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] | 17 | 3.083174e-03 | 0 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 5 | 3.187679e-03 | 0 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 13 | 4.450277e-03 | 0 |
| GO:CC | GO:0035525 | NF-kappaB p50/p65 complex | "A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584] | 2 | 4.492257e-03 | 0 |
| GO:CC | GO:1990909 | Wnt signalosome | "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320] | 3 | 4.683006e-03 | 0 |
| GO:CC | GO:0042382 | paraspeckles | "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299] | 3 | 4.683006e-03 | 0 |
| GO:CC | GO:0005662 | DNA replication factor A complex | "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] | 3 | 4.683006e-03 | 0 |
| GO:CC | GO:0043596 | nuclear replication fork | "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] | 4 | 5.665141e-03 | 0 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 13 | 9.748884e-03 | 0 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 7 | 1.044165e-02 | 0 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 19 | 1.083228e-02 | 0 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 22 | 1.448331e-02 | 0 |
| GO:CC | GO:0097225 | sperm midpiece | "The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece." [GOC:cjm, MP:0009831] | 4 | 2.108890e-02 | 0 |
| GO:CC | GO:0043601 | nuclear replisome | "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] | 3 | 2.459421e-02 | 0 |
| GO:CC | GO:0030894 | replisome | "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] | 3 | 3.214506e-02 | 0 |
| GO:CC | GO:0099523 | presynaptic cytosol | "The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos] | 3 | 3.642736e-02 | 0 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 11 | 4.007536e-02 | 0 |
| GO:CC | GO:0106002 | mCRD-mediated mRNA stability complex | "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP." [GOC:bhm, PMID:11051545] | 2 | 4.458679e-02 | 0 |
| GO:CC | GO:0071159 | NF-kappaB complex | "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946] | 2 | 4.458679e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 35 | 2.992745e-20 | 0 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 41 | 5.484864e-17 | 0 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 44 | 3.493436e-16 | 0 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 28 | 5.919421e-16 | 0 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 32 | 3.301585e-15 | 0 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 31 | 5.809123e-15 | 0 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 22 | 9.220940e-15 | 0 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 29 | 2.318944e-14 | 0 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 29 | 2.630035e-14 | 0 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 30 | 2.912276e-14 | 0 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 29 | 3.518821e-14 | 0 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 29 | 6.488435e-14 | 0 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 31 | 9.108046e-14 | 0 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 34 | 9.937234e-14 | 0 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 27 | 1.000496e-13 | 0 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 31 | 1.441750e-13 | 0 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 29 | 1.488683e-13 | 0 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 32 | 1.747310e-13 | 0 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 37 | 2.227550e-13 | 0 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 30 | 2.403105e-13 | 0 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 32 | 3.046226e-13 | 0 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 27 | 3.504894e-13 | 0 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 31 | 4.166490e-13 | 0 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 28 | 4.168876e-13 | 0 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 29 | 6.000957e-13 | 0 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 29 | 6.942417e-13 | 0 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 26 | 1.676396e-12 | 0 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 26 | 1.898095e-12 | 0 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 31 | 1.973745e-12 | 0 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 33 | 2.193054e-12 | 0 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 27 | 2.230852e-12 | 0 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 31 | 2.236805e-12 | 0 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 20 | 2.412944e-12 | 0 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 33 | 3.351284e-12 | 0 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 26 | 3.493664e-12 | 0 |
| HPA | HPA:0471492 | Skin 2; vascular mural cells[≥Medium] | Skin 2; vascular mural cells[≥Medium] | 17 | 3.733181e-12 | 0 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 28 | 3.776450e-12 | 0 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 28 | 4.054125e-12 | 0 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 30 | 4.415171e-12 | 0 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 25 | 7.880511e-12 | 0 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 38 | 8.068450e-12 | 0 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 23 | 8.761192e-12 | 0 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 22 | 9.043511e-12 | 0 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 29 | 9.078752e-12 | 0 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 20 | 1.066113e-11 | 0 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 68 | 1.111245e-11 | 0 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 34 | 1.114094e-11 | 0 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 33 | 1.493578e-11 | 0 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 30 | 1.821422e-11 | 0 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 31 | 2.199805e-11 | 0 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 61 | 2.822260e-11 | 0 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 55 | 3.767487e-11 | 0 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 41 | 4.488714e-11 | 0 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 21 | 5.090833e-11 | 0 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 60 | 5.218212e-11 | 0 |
| HPA | HPA:0461393 | Skin 1; cells in basal layer[High] | Skin 1; cells in basal layer[High] | 16 | 5.785419e-11 | 0 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 14 | 5.846953e-11 | 0 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 39 | 8.188666e-11 | 0 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 19 | 1.023915e-10 | 0 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 14 | 1.105745e-10 | 0 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 13 | 1.157703e-10 | 0 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 62 | 1.192489e-10 | 0 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 22 | 1.420720e-10 | 0 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 17 | 1.490169e-10 | 0 |
| HPA | HPA:0510653 | Soft tissue 2; fibroblasts[High] | Soft tissue 2; fibroblasts[High] | 23 | 1.527264e-10 | 0 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 43 | 1.673670e-10 | 0 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 16 | 2.023473e-10 | 0 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 60 | 2.183509e-10 | 0 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 66 | 3.145809e-10 | 0 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 32 | 3.369455e-10 | 0 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 16 | 4.502360e-10 | 0 |
| HPA | HPA:0400651 | Rectum; fibroblasts[≥Low] | Rectum; fibroblasts[≥Low] | 13 | 5.713649e-10 | 0 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 55 | 6.721750e-10 | 0 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 15 | 7.736062e-10 | 0 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 17 | 7.895861e-10 | 0 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 19 | 8.514277e-10 | 0 |
| HPA | HPA:0510652 | Soft tissue 2; fibroblasts[≥Medium] | Soft tissue 2; fibroblasts[≥Medium] | 47 | 1.389191e-09 | 0 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 35 | 2.290588e-09 | 0 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 35 | 2.336188e-09 | 0 |
| HPA | HPA:0500653 | Soft tissue 1; fibroblasts[High] | Soft tissue 1; fibroblasts[High] | 22 | 2.677699e-09 | 0 |
| HPA | HPA:0340000 | Ovary | Ovary | 67 | 3.003564e-09 | 0 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 70 | 3.207852e-09 | 0 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 46 | 3.394253e-09 | 0 |
| HPA | HPA:0510703 | Soft tissue 2; peripheral nerve[High] | Soft tissue 2; peripheral nerve[High] | 17 | 3.712281e-09 | 0 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 28 | 3.962413e-09 | 0 |
| HPA | HPA:0570773 | Testis; peritubular cells[High] | Testis; peritubular cells[High] | 15 | 5.686213e-09 | 0 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 33 | 6.032643e-09 | 0 |
| HPA | HPA:0400202 | Rectum; endothelial cells[≥Medium] | Rectum; endothelial cells[≥Medium] | 14 | 8.392841e-09 | 0 |
| HPA | HPA:0050093 | Breast; myoepithelial cells[High] | Breast; myoepithelial cells[High] | 26 | 9.961478e-09 | 0 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 38 | 1.377026e-08 | 0 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 36 | 1.382955e-08 | 0 |
| HPA | HPA:0050012 | Breast; adipocytes[≥Medium] | Breast; adipocytes[≥Medium] | 34 | 1.705271e-08 | 0 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 18 | 2.284088e-08 | 0 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 73 | 2.314903e-08 | 0 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 32 | 2.332876e-08 | 0 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 49 | 2.575776e-08 | 0 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 15 | 2.682075e-08 | 0 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 15 | 3.788813e-08 | 0 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 30 | 5.013433e-08 | 0 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 62 | 5.067207e-08 | 0 |
| HPA | HPA:0400201 | Rectum; endothelial cells[≥Low] | Rectum; endothelial cells[≥Low] | 15 | 5.302579e-08 | 0 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 63 | 5.633745e-08 | 0 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 33 | 6.244671e-08 | 0 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 39 | 6.366211e-08 | 0 |
| HPA | HPA:0630000 | Cervix | Cervix | 73 | 6.741008e-08 | 0 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 26 | 7.859177e-08 | 0 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 15 | 8.187834e-08 | 0 |
| HPA | HPA:0170253 | Endometrium 2; cells in endometrial stroma[High] | Endometrium 2; cells in endometrial stroma[High] | 17 | 8.611536e-08 | 0 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 62 | 8.863049e-08 | 0 |
| HPA | HPA:0050000 | Breast | Breast | 74 | 8.925887e-08 | 0 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 38 | 9.185875e-08 | 0 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 58 | 1.006612e-07 | 0 |
| HPA | HPA:0390053 | Prostate; glandular cells[High] | Prostate; glandular cells[High] | 31 | 1.209225e-07 | 0 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 64 | 1.276985e-07 | 0 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 55 | 1.281687e-07 | 0 |
| HPA | HPA:0630053 | Cervix; glandular cells[High] | Cervix; glandular cells[High] | 29 | 1.505581e-07 | 0 |
| HPA | HPA:0351183 | Pancreas; pancreatic endocrine cells[High] | Pancreas; pancreatic endocrine cells[High] | 24 | 1.550638e-07 | 0 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 66 | 2.129146e-07 | 0 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 73 | 2.307223e-07 | 0 |
| HPA | HPA:0060103 | Bronchus; respiratory epithelial cells[High] | Bronchus; respiratory epithelial cells[High] | 36 | 2.446424e-07 | 0 |
| HPA | HPA:0570783 | Testis; preleptotene spermatocytes[High] | Testis; preleptotene spermatocytes[High] | 23 | 2.497657e-07 | 0 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 22 | 2.546381e-07 | 0 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 74 | 2.616395e-07 | 0 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 74 | 2.616395e-07 | 0 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 69 | 2.727469e-07 | 0 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 69 | 2.727469e-07 | 0 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 71 | 2.735099e-07 | 0 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 58 | 2.741269e-07 | 0 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 32 | 2.787374e-07 | 0 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 16 | 2.820140e-07 | 0 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 53 | 2.959359e-07 | 0 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 61 | 3.428901e-07 | 0 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 71 | 3.569423e-07 | 0 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 71 | 3.569423e-07 | 0 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 14 | 4.087693e-07 | 0 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 14 | 4.087693e-07 | 0 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 54 | 4.219291e-07 | 0 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 54 | 4.219291e-07 | 0 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 68 | 4.516270e-07 | 0 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 72 | 4.759799e-07 | 0 |
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 30 | 4.779654e-07 | 0 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 36 | 5.224595e-07 | 0 |
| HPA | HPA:0010013 | Adipose tissue; adipocytes[High] | Adipose tissue; adipocytes[High] | 18 | 5.254192e-07 | 0 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 57 | 7.138022e-07 | 0 |
| HPA | HPA:0130651 | Colon; fibroblasts[≥Low] | Colon; fibroblasts[≥Low] | 10 | 7.753425e-07 | 0 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 40 | 7.773108e-07 | 0 |
| HPA | HPA:0050013 | Breast; adipocytes[High] | Breast; adipocytes[High] | 15 | 8.367878e-07 | 0 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 73 | 8.524586e-07 | 0 |
| HPA | HPA:0440343 | Skeletal muscle; myocytes[High] | Skeletal muscle; myocytes[High] | 24 | 9.135062e-07 | 0 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 44 | 1.005565e-06 | 0 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 39 | 1.046167e-06 | 0 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 62 | 1.105551e-06 | 0 |
| HPA | HPA:0400000 | Rectum | Rectum | 76 | 1.124689e-06 | 0 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 44 | 1.160520e-06 | 0 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 54 | 1.272277e-06 | 0 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 28 | 1.319483e-06 | 0 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 72 | 1.334700e-06 | 0 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 66 | 1.408328e-06 | 0 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 66 | 1.408328e-06 | 0 |
| HPA | HPA:0160253 | Endometrium 1; cells in endometrial stroma[High] | Endometrium 1; cells in endometrial stroma[High] | 17 | 1.670489e-06 | 0 |
| HPA | HPA:0131302 | Colon; enterocytes[≥Medium] | Colon; enterocytes[≥Medium] | 16 | 1.732022e-06 | 0 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 43 | 1.955384e-06 | 0 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 51 | 2.242218e-06 | 0 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 16 | 2.245664e-06 | 0 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 34 | 2.302425e-06 | 0 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 66 | 2.474161e-06 | 0 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 63 | 2.509529e-06 | 0 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 64 | 2.610078e-06 | 0 |
| HPA | HPA:0131333 | Colon; mucosal lymphoid cells[High] | Colon; mucosal lymphoid cells[High] | 11 | 2.667287e-06 | 0 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 54 | 2.767373e-06 | 0 |
| HPA | HPA:0500703 | Soft tissue 1; peripheral nerve[High] | Soft tissue 1; peripheral nerve[High] | 13 | 2.868184e-06 | 0 |
| HPA | HPA:0270353 | Kidney; cells in glomeruli[High] | Kidney; cells in glomeruli[High] | 23 | 2.887536e-06 | 0 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 51 | 2.896903e-06 | 0 |
| HPA | HPA:0400653 | Rectum; fibroblasts[High] | Rectum; fibroblasts[High] | 8 | 2.965705e-06 | 0 |
| HPA | HPA:0130243 | Colon; peripheral nerve/ganglion[High] | Colon; peripheral nerve/ganglion[High] | 23 | 3.018275e-06 | 0 |
| HPA | HPA:0461453 | Skin 1; hair follicles[High] | Skin 1; hair follicles[High] | 10 | 3.064091e-06 | 0 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 69 | 3.149097e-06 | 0 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 70 | 3.187299e-06 | 0 |
| HPA | HPA:0030000 | Appendix | Appendix | 75 | 3.398793e-06 | 0 |
| HPA | HPA:0481303 | Small intestine; enterocytes[High] | Small intestine; enterocytes[High] | 13 | 3.493234e-06 | 0 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 66 | 3.647332e-06 | 0 |
| HPA | HPA:0620000 | Vagina | Vagina | 66 | 3.647332e-06 | 0 |
| HPA | HPA:0570771 | Testis; peritubular cells[≥Low] | Testis; peritubular cells[≥Low] | 21 | 4.187595e-06 | 0 |
| HPA | HPA:0570772 | Testis; peritubular cells[≥Medium] | Testis; peritubular cells[≥Medium] | 18 | 4.449222e-06 | 0 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 42 | 4.673280e-06 | 0 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 72 | 5.476019e-06 | 0 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 34 | 5.584229e-06 | 0 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 73 | 6.601599e-06 | 0 |
| HPA | HPA:0130242 | Colon; peripheral nerve/ganglion[≥Medium] | Colon; peripheral nerve/ganglion[≥Medium] | 48 | 6.655864e-06 | 0 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 30 | 6.736297e-06 | 0 |
| HPA | HPA:0530000 | Spleen | Spleen | 65 | 6.824535e-06 | 0 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 70 | 7.151992e-06 | 0 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 42 | 7.747369e-06 | 0 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 73 | 8.744856e-06 | 0 |
| HPA | HPA:0400203 | Rectum; endothelial cells[High] | Rectum; endothelial cells[High] | 9 | 9.009810e-06 | 0 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 18 | 9.610294e-06 | 0 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 11 | 9.928992e-06 | 0 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 68 | 1.194127e-05 | 0 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 68 | 1.194127e-05 | 0 |
| HPA | HPA:0380000 | Placenta | Placenta | 73 | 1.290108e-05 | 0 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 27 | 1.377415e-05 | 0 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 37 | 1.562998e-05 | 0 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 67 | 1.582436e-05 | 0 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 58 | 1.708633e-05 | 0 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 71 | 1.734259e-05 | 0 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 71 | 1.734259e-05 | 0 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 72 | 1.786010e-05 | 0 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 72 | 1.786010e-05 | 0 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 74 | 1.892786e-05 | 0 |
| HPA | HPA:0130892 | Colon; goblet cells[≥Medium] | Colon; goblet cells[≥Medium] | 14 | 1.945933e-05 | 0 |
| HPA | HPA:0300413 | Lung; macrophages[High] | Lung; macrophages[High] | 28 | 2.051239e-05 | 0 |
| HPA | HPA:0400242 | Rectum; peripheral nerve/ganglion[≥Medium] | Rectum; peripheral nerve/ganglion[≥Medium] | 11 | 2.289199e-05 | 0 |
| HPA | HPA:0480892 | Small intestine; goblet cells[≥Medium] | Small intestine; goblet cells[≥Medium] | 14 | 2.336908e-05 | 0 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 53 | 2.592349e-05 | 0 |
| HPA | HPA:0131292 | Colon; endocrine cells[≥Medium] | Colon; endocrine cells[≥Medium] | 15 | 2.605972e-05 | 0 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 69 | 2.608853e-05 | 0 |
| HPA | HPA:0130000 | Colon | Colon | 76 | 2.707546e-05 | 0 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 53 | 2.812696e-05 | 0 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 15 | 2.872052e-05 | 0 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 57 | 2.894709e-05 | 0 |
| HPA | HPA:0270352 | Kidney; cells in glomeruli[≥Medium] | Kidney; cells in glomeruli[≥Medium] | 44 | 3.082193e-05 | 0 |
| HPA | HPA:0130653 | Colon; fibroblasts[High] | Colon; fibroblasts[High] | 7 | 3.225489e-05 | 0 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 72 | 3.317105e-05 | 0 |
| HPA | HPA:0570803 | Testis; sertoli cells[High] | Testis; sertoli cells[High] | 18 | 3.479213e-05 | 0 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 72 | 3.512660e-05 | 0 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 51 | 3.515912e-05 | 0 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 53 | 3.522862e-05 | 0 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 39 | 4.165071e-05 | 0 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 60 | 4.202735e-05 | 0 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 38 | 4.243650e-05 | 0 |
| HPA | HPA:0031301 | Appendix; enterocytes[≥Low] | Appendix; enterocytes[≥Low] | 16 | 4.252804e-05 | 0 |
| HPA | HPA:0290000 | Liver | Liver | 66 | 4.324148e-05 | 0 |
| HPA | HPA:0130893 | Colon; goblet cells[High] | Colon; goblet cells[High] | 11 | 4.455945e-05 | 0 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 74 | 4.713355e-05 | 0 |
| HPA | HPA:0031302 | Appendix; enterocytes[≥Medium] | Appendix; enterocytes[≥Medium] | 14 | 4.877226e-05 | 0 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 55 | 4.892716e-05 | 0 |
| HPA | HPA:0480893 | Small intestine; goblet cells[High] | Small intestine; goblet cells[High] | 11 | 4.915609e-05 | 0 |
| HPA | HPA:0490693 | Smooth muscle; smooth muscle cells[High] | Smooth muscle; smooth muscle cells[High] | 18 | 5.404419e-05 | 0 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 14 | 5.578822e-05 | 0 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 60 | 5.668381e-05 | 0 |
| HPA | HPA:0031292 | Appendix; endocrine cells[≥Medium] | Appendix; endocrine cells[≥Medium] | 14 | 5.962703e-05 | 0 |
| HPA | HPA:0400241 | Rectum; peripheral nerve/ganglion[≥Low] | Rectum; peripheral nerve/ganglion[≥Low] | 12 | 6.077463e-05 | 0 |
| HPA | HPA:0400893 | Rectum; goblet cells[High] | Rectum; goblet cells[High] | 11 | 6.253728e-05 | 0 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 13 | 6.426378e-05 | 0 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 62 | 6.649498e-05 | 0 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 69 | 6.887105e-05 | 0 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 69 | 6.887105e-05 | 0 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 60 | 6.963247e-05 | 0 |
| HPA | HPA:0130203 | Colon; endothelial cells[High] | Colon; endothelial cells[High] | 21 | 7.079903e-05 | 0 |
| HPA | HPA:0131303 | Colon; enterocytes[High] | Colon; enterocytes[High] | 11 | 7.905118e-05 | 0 |
| HPA | HPA:0500113 | Soft tissue 1; chondrocytes[High] | Soft tissue 1; chondrocytes[High] | 13 | 8.276281e-05 | 0 |
| HPA | HPA:0130652 | Colon; fibroblasts[≥Medium] | Colon; fibroblasts[≥Medium] | 8 | 8.417828e-05 | 0 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 59 | 8.455132e-05 | 0 |
| HPA | HPA:0291163 | Liver; cholangiocytes[High] | Liver; cholangiocytes[High] | 13 | 8.576295e-05 | 0 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 15 | 8.909854e-05 | 0 |
| HPA | HPA:0131301 | Colon; enterocytes[≥Low] | Colon; enterocytes[≥Low] | 16 | 8.953641e-05 | 0 |
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 33 | 8.982455e-05 | 0 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 22 | 9.485556e-05 | 0 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 36 | 9.874052e-05 | 0 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 65 | 9.877673e-05 | 0 |
| HPA | HPA:0131291 | Colon; endocrine cells[≥Low] | Colon; endocrine cells[≥Low] | 15 | 1.000053e-04 | 0 |
| HPA | HPA:0131331 | Colon; mucosal lymphoid cells[≥Low] | Colon; mucosal lymphoid cells[≥Low] | 16 | 1.022226e-04 | 0 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 64 | 1.064160e-04 | 0 |
| HPA | HPA:0401301 | Rectum; enterocytes[≥Low] | Rectum; enterocytes[≥Low] | 16 | 1.105968e-04 | 0 |
| HPA | HPA:0080000 | Caudate | Caudate | 69 | 1.142583e-04 | 0 |
| HPA | HPA:0401291 | Rectum; endocrine cells[≥Low] | Rectum; endocrine cells[≥Low] | 15 | 1.153312e-04 | 0 |
| HPA | HPA:0570782 | Testis; preleptotene spermatocytes[≥Medium] | Testis; preleptotene spermatocytes[≥Medium] | 28 | 1.193379e-04 | 0 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 41 | 1.237966e-04 | 0 |
| HPA | HPA:0401303 | Rectum; enterocytes[High] | Rectum; enterocytes[High] | 11 | 1.240458e-04 | 0 |
| HPA | HPA:0300000 | Lung | Lung | 71 | 1.277545e-04 | 0 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 51 | 1.406969e-04 | 0 |
| HPA | HPA:0481292 | Small intestine; endocrine cells[≥Medium] | Small intestine; endocrine cells[≥Medium] | 15 | 1.483618e-04 | 0 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 33 | 1.524400e-04 | 0 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 14 | 1.587545e-04 | 0 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 68 | 1.673624e-04 | 0 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 68 | 1.673624e-04 | 0 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 58 | 1.689485e-04 | 0 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 68 | 1.699740e-04 | 0 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 19 | 1.723007e-04 | 0 |
| HPA | HPA:0481293 | Small intestine; endocrine cells[High] | Small intestine; endocrine cells[High] | 12 | 1.750888e-04 | 0 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 13 | 1.759888e-04 | 0 |
| HPA | HPA:0031303 | Appendix; enterocytes[High] | Appendix; enterocytes[High] | 10 | 1.912793e-04 | 0 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 61 | 2.086583e-04 | 0 |
| HPA | HPA:0151301 | Duodenum; enterocytes[≥Low] | Duodenum; enterocytes[≥Low] | 16 | 2.138423e-04 | 0 |
| HPA | HPA:0461452 | Skin 1; hair follicles[≥Medium] | Skin 1; hair follicles[≥Medium] | 12 | 2.180231e-04 | 0 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 70 | 2.185898e-04 | 0 |
| HPA | HPA:0480891 | Small intestine; goblet cells[≥Low] | Small intestine; goblet cells[≥Low] | 14 | 2.198620e-04 | 0 |
| HPA | HPA:0400891 | Rectum; goblet cells[≥Low] | Rectum; goblet cells[≥Low] | 14 | 2.198620e-04 | 0 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 51 | 2.285296e-04 | 0 |
| HPA | HPA:0500702 | Soft tissue 1; peripheral nerve[≥Medium] | Soft tissue 1; peripheral nerve[≥Medium] | 26 | 2.316835e-04 | 0 |
| HPA | HPA:0130891 | Colon; goblet cells[≥Low] | Colon; goblet cells[≥Low] | 14 | 2.330070e-04 | 0 |
| HPA | HPA:0241103 | Heart muscle; cardiomyocytes[High] | Heart muscle; cardiomyocytes[High] | 24 | 2.380042e-04 | 0 |
| HPA | HPA:0401331 | Rectum; mucosal lymphoid cells[≥Low] | Rectum; mucosal lymphoid cells[≥Low] | 16 | 2.416523e-04 | 0 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 74 | 2.433909e-04 | 0 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 72 | 2.434001e-04 | 0 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 72 | 2.434001e-04 | 0 |
| HPA | HPA:0510702 | Soft tissue 2; peripheral nerve[≥Medium] | Soft tissue 2; peripheral nerve[≥Medium] | 28 | 2.456258e-04 | 0 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 54 | 2.534573e-04 | 0 |
| HPA | HPA:0031291 | Appendix; endocrine cells[≥Low] | Appendix; endocrine cells[≥Low] | 14 | 2.847574e-04 | 0 |
| HPA | HPA:0400243 | Rectum; peripheral nerve/ganglion[High] | Rectum; peripheral nerve/ganglion[High] | 8 | 2.949359e-04 | 0 |
| HPA | HPA:0131293 | Colon; endocrine cells[High] | Colon; endocrine cells[High] | 11 | 3.221729e-04 | 0 |
| HPA | HPA:0151291 | Duodenum; endocrine cells[≥Low] | Duodenum; endocrine cells[≥Low] | 15 | 3.555527e-04 | 0 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 14 | 3.563492e-04 | 0 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 60 | 3.594971e-04 | 0 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 54 | 3.612791e-04 | 0 |
| HPA | HPA:0481291 | Small intestine; endocrine cells[≥Low] | Small intestine; endocrine cells[≥Low] | 15 | 3.646795e-04 | 0 |
| HPA | HPA:0461451 | Skin 1; hair follicles[≥Low] | Skin 1; hair follicles[≥Low] | 13 | 3.762267e-04 | 0 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 22 | 3.823548e-04 | 0 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 68 | 4.024598e-04 | 0 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 56 | 4.298316e-04 | 0 |
| HPA | HPA:0150893 | Duodenum; goblet cells[High] | Duodenum; goblet cells[High] | 10 | 4.381931e-04 | 0 |
| HPA | HPA:0481301 | Small intestine; enterocytes[≥Low] | Small intestine; enterocytes[≥Low] | 16 | 4.567690e-04 | 0 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 46 | 4.611597e-04 | 0 |
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 31 | 5.060959e-04 | 0 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 66 | 5.086229e-04 | 0 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 64 | 5.617913e-04 | 0 |
| HPA | HPA:0570792 | Testis; round or early spermatids[≥Medium] | Testis; round or early spermatids[≥Medium] | 31 | 5.808160e-04 | 0 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 36 | 5.931094e-04 | 0 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 54 | 6.224781e-04 | 0 |
| HPA | HPA:0401293 | Rectum; endocrine cells[High] | Rectum; endocrine cells[High] | 11 | 6.346875e-04 | 0 |
| HPA | HPA:0030891 | Appendix; goblet cells[≥Low] | Appendix; goblet cells[≥Low] | 13 | 6.401569e-04 | 0 |
| HPA | HPA:0270000 | Kidney | Kidney | 74 | 6.595217e-04 | 0 |
| HPA | HPA:0340452 | Ovary; follicle cells[≥Medium] | Ovary; follicle cells[≥Medium] | 34 | 7.036791e-04 | 0 |
| HPA | HPA:0530713 | Spleen; cells in red pulp[High] | Spleen; cells in red pulp[High] | 19 | 7.390319e-04 | 0 |
| HPA | HPA:0570000 | Testis | Testis | 77 | 7.446180e-04 | 0 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 70 | 7.490922e-04 | 0 |
| HPA | HPA:0390000 | Prostate | Prostate | 66 | 7.977089e-04 | 0 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 66 | 7.977089e-04 | 0 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 60 | 8.796360e-04 | 0 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 12 | 8.836913e-04 | 0 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 62 | 9.011052e-04 | 0 |
| HPA | HPA:0360053 | Parathyroid gland; glandular cells[High] | Parathyroid gland; glandular cells[High] | 27 | 9.321494e-04 | 0 |
| HPA | HPA:0090183 | Cerebellum; cells in granular layer[High] | Cerebellum; cells in granular layer[High] | 18 | 9.403019e-04 | 0 |
| HPA | HPA:0130202 | Colon; endothelial cells[≥Medium] | Colon; endothelial cells[≥Medium] | 46 | 9.697734e-04 | 0 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 45 | 9.708579e-04 | 0 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 66 | 1.029143e-03 | 0 |
| HPA | HPA:0150891 | Duodenum; goblet cells[≥Low] | Duodenum; goblet cells[≥Low] | 13 | 1.086665e-03 | 0 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 71 | 1.116438e-03 | 0 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 71 | 1.116438e-03 | 0 |
| HPA | HPA:0030893 | Appendix; goblet cells[High] | Appendix; goblet cells[High] | 9 | 1.126357e-03 | 0 |
| HPA | HPA:0030073 | Appendix; lymphoid tissue[High] | Appendix; lymphoid tissue[High] | 18 | 1.131241e-03 | 0 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 40 | 1.186099e-03 | 0 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 22 | 1.224200e-03 | 0 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 72 | 1.239655e-03 | 0 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 54 | 1.276901e-03 | 0 |
| HPA | HPA:0151303 | Duodenum; enterocytes[High] | Duodenum; enterocytes[High] | 10 | 1.314416e-03 | 0 |
| HPA | HPA:0340453 | Ovary; follicle cells[High] | Ovary; follicle cells[High] | 16 | 1.322611e-03 | 0 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 58 | 1.434425e-03 | 0 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 58 | 1.434425e-03 | 0 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 60 | 1.507868e-03 | 0 |
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 30 | 1.600212e-03 | 0 |
| HPA | HPA:0030443 | Appendix; non-germinal center cells[High] | Appendix; non-germinal center cells[High] | 7 | 1.985928e-03 | 0 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 55 | 2.006570e-03 | 0 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 54 | 2.160104e-03 | 0 |
| HPA | HPA:0510701 | Soft tissue 2; peripheral nerve[≥Low] | Soft tissue 2; peripheral nerve[≥Low] | 41 | 2.474714e-03 | 0 |
| HPA | HPA:0151352 | Duodenum; paneth cells[≥Medium] | Duodenum; paneth cells[≥Medium] | 10 | 2.525093e-03 | 0 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 26 | 3.017489e-03 | 0 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 48 | 3.027946e-03 | 0 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 70 | 3.198159e-03 | 0 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 70 | 3.198159e-03 | 0 |
| HPA | HPA:0151292 | Duodenum; endocrine cells[≥Medium] | Duodenum; endocrine cells[≥Medium] | 13 | 3.315701e-03 | 0 |
| HPA | HPA:0090181 | Cerebellum; cells in granular layer[≥Low] | Cerebellum; cells in granular layer[≥Low] | 51 | 3.319431e-03 | 0 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 59 | 3.849461e-03 | 0 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 60 | 4.144680e-03 | 0 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 55 | 4.305248e-03 | 0 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 47 | 4.390432e-03 | 0 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 53 | 4.578437e-03 | 0 |
| HPA | HPA:0461482 | Skin 1; sebaceous glands[≥Medium] | Skin 1; sebaceous glands[≥Medium] | 8 | 4.918879e-03 | 0 |
| HPA | HPA:0151353 | Duodenum; paneth cells[High] | Duodenum; paneth cells[High] | 8 | 5.366617e-03 | 0 |
| HPA | HPA:0090182 | Cerebellum; cells in granular layer[≥Medium] | Cerebellum; cells in granular layer[≥Medium] | 38 | 5.492731e-03 | 0 |
| HPA | HPA:0151351 | Duodenum; paneth cells[≥Low] | Duodenum; paneth cells[≥Low] | 10 | 5.914868e-03 | 0 |
| HPA | HPA:0570761 | Testis; pachytene spermatocytes[≥Low] | Testis; pachytene spermatocytes[≥Low] | 33 | 6.437503e-03 | 0 |
| HPA | HPA:0030432 | Appendix; germinal center cells[≥Medium] | Appendix; germinal center cells[≥Medium] | 9 | 7.010298e-03 | 0 |
| HPA | HPA:0031293 | Appendix; endocrine cells[High] | Appendix; endocrine cells[High] | 9 | 7.513695e-03 | 0 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 61 | 7.714893e-03 | 0 |
| HPA | HPA:0100203 | Cerebral cortex; endothelial cells[High] | Cerebral cortex; endothelial cells[High] | 12 | 8.385405e-03 | 0 |
| HPA | HPA:0460663 | Skin 1; keratinocytes[High] | Skin 1; keratinocytes[High] | 15 | 9.770913e-03 | 0 |
| HPA | HPA:0570802 | Testis; sertoli cells[≥Medium] | Testis; sertoli cells[≥Medium] | 28 | 1.002628e-02 | 0 |
| HPA | HPA:0490692 | Smooth muscle; smooth muscle cells[≥Medium] | Smooth muscle; smooth muscle cells[≥Medium] | 39 | 1.016703e-02 | 0 |
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 6 | 1.021848e-02 | 0 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 57 | 1.146998e-02 | 0 |
| HPA | HPA:0530712 | Spleen; cells in red pulp[≥Medium] | Spleen; cells in red pulp[≥Medium] | 39 | 1.207204e-02 | 0 |
| HPA | HPA:0151293 | Duodenum; endocrine cells[High] | Duodenum; endocrine cells[High] | 10 | 1.230504e-02 | 0 |
| HPA | HPA:0570791 | Testis; round or early spermatids[≥Low] | Testis; round or early spermatids[≥Low] | 32 | 1.245119e-02 | 0 |
| HPA | HPA:0500701 | Soft tissue 1; peripheral nerve[≥Low] | Soft tissue 1; peripheral nerve[≥Low] | 36 | 1.295171e-02 | 0 |
| HPA | HPA:0130241 | Colon; peripheral nerve/ganglion[≥Low] | Colon; peripheral nerve/ganglion[≥Low] | 53 | 1.403234e-02 | 0 |
| HPA | HPA:0340451 | Ovary; follicle cells[≥Low] | Ovary; follicle cells[≥Low] | 40 | 1.568190e-02 | 0 |
| HPA | HPA:0530723 | Spleen; cells in white pulp[High] | Spleen; cells in white pulp[High] | 17 | 1.741589e-02 | 0 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 28 | 1.953466e-02 | 0 |
| HPA | HPA:0270363 | Kidney; cells in tubules[High] | Kidney; cells in tubules[High] | 30 | 2.070774e-02 | 0 |
| HPA | HPA:0461481 | Skin 1; sebaceous glands[≥Low] | Skin 1; sebaceous glands[≥Low] | 8 | 2.076746e-02 | 0 |
| HPA | HPA:0481353 | Small intestine; paneth cells[High] | Small intestine; paneth cells[High] | 7 | 2.119363e-02 | 0 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 30 | 2.624078e-02 | 0 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 61 | 2.707729e-02 | 0 |
| HPA | HPA:0471452 | Skin 2; hair follicles[≥Medium] | Skin 2; hair follicles[≥Medium] | 7 | 3.175114e-02 | 0 |
| HPA | HPA:0030431 | Appendix; germinal center cells[≥Low] | Appendix; germinal center cells[≥Low] | 9 | 4.291202e-02 | 0 |
| HPA | HPA:0481352 | Small intestine; paneth cells[≥Medium] | Small intestine; paneth cells[≥Medium] | 8 | 4.516222e-02 | 0 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 45 | 4.863709e-02 | 0 |
| HPA | HPA:0100202 | Cerebral cortex; endothelial cells[≥Medium] | Cerebral cortex; endothelial cells[≥Medium] | 32 | 4.878613e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 35 | 3.031932e-19 | 0 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 33 | 3.568558e-11 | 0 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 27 | 8.245235e-08 | 0 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 19 | 1.199311e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-30a-5p | hsa-mir-30a-5p | hsa-mir-30a-5p | 17 | 4.679877e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 13 | 6.352822e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-30c-5p | hsa-mir-30c-5p | hsa-mir-30c-5p | 14 | 1.443679e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-149-5p | hsa-mir-149-5p | hsa-mir-149-5p | 12 | 3.155988e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-15b-5p | hsa-mir-15b-5p | hsa-mir-15b-5p | 16 | 4.794536e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 25 | 4.883455e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-17-3p | hsa-mir-17-3p | hsa-mir-17-3p | 8 | 7.172503e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-378a-3p | hsa-mir-378a-3p | hsa-mir-378a-3p | 8 | 1.232908e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-17-5p | hsa-mir-17-5p | hsa-mir-17-5p | 19 | 2.200930e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-1301-3p | hsa-mir-1301-3p | hsa-mir-1301-3p | 8 | 4.131827e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 13 | 4.654069e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-15a-5p | hsa-mir-15a-5p | hsa-mir-15a-5p | 14 | 5.584905e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-296-3p | hsa-mir-296-3p | hsa-mir-296-3p | 15 | 6.161920e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-125b-5p | hsa-mir-125b-5p | hsa-mir-125b-5p | 11 | 6.486263e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-26a-5p | hsa-mir-26a-5p | hsa-mir-26a-5p | 11 | 8.680625e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-3617 | hsa-mir-3617 | hsa-mir-3617 | 19 | 9.515064e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-25-3p | hsa-mir-25-3p | hsa-mir-25-3p | 11 | 1.033109e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-877-5p | hsa-mir-877-5p | hsa-mir-877-5p | 8 | 1.071612e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-221-3p | hsa-mir-221-3p | hsa-mir-221-3p | 10 | 1.205012e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-641 | hsa-mir-641 | hsa-mir-641 | 19 | 1.645909e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-222-3p | hsa-mir-222-3p | hsa-mir-222-3p | 10 | 1.673501e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4694-3p | hsa-mir-4694-3p | hsa-mir-4694-3p | 19 | 1.682097e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-1296-5p | hsa-mir-1296-5p | hsa-mir-1296-5p | 6 | 1.892211e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-484 | hsa-mir-484 | hsa-mir-484 | 24 | 2.588430e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-580 | hsa-mir-580 | hsa-mir-580 | 17 | 2.906656e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-18a-5p | hsa-mir-18a-5p | hsa-mir-18a-5p | 8 | 3.380089e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-548z | hsa-mir-548z | hsa-mir-548z | 23 | 3.578503e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-548ac | hsa-mir-548ac | hsa-mir-548ac | 23 | 3.578503e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-548d-3p | hsa-mir-548d-3p | hsa-mir-548d-3p | 23 | 3.732399e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-324-5p | hsa-mir-324-5p | hsa-mir-324-5p | 14 | 3.764269e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-375 | hsa-mir-375 | hsa-mir-375 | 16 | 3.966308e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3662 | hsa-mir-3662 | hsa-mir-3662 | 26 | 4.042897e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-496 | hsa-mir-496 | hsa-mir-496 | 12 | 4.152125e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-200a | hsa-mir-200a | hsa-mir-200a | 20 | 4.214953e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-141 | hsa-mir-141 | hsa-mir-141 | 20 | 4.214953e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 17 | 2.887915e-14 | 0 |
| WP | WP:WP2359 | Parkin ubiquitin proteasomal system pathway | Parkin ubiquitin proteasomal system pathway | 9 | 3.083954e-06 | 0 |
| WP | WP:WP411 | mRNA processing | mRNA processing | 11 | 3.901715e-06 | 0 |
| WP | WP:WP3594 | Circadian rhythm genes | Circadian rhythm genes | 13 | 6.543124e-06 | 0 |
| WP | WP:WP2036 | TNF related weak inducer of apoptosis TWEAK signaling | TNF related weak inducer of apoptosis TWEAK signaling | 7 | 9.103920e-06 | 0 |
| WP | WP:WP4659 | Gastrin signaling | Gastrin signaling | 10 | 1.717011e-05 | 0 |
| WP | WP:WP5475 | Hallmark of cancer sustaining proliferative signaling | Hallmark of cancer sustaining proliferative signaling | 9 | 5.313899e-05 | 0 |
| WP | WP:WP3981 | miRNA regulation of prostate cancer signaling | miRNA regulation of prostate cancer signaling | 6 | 6.404222e-05 | 0 |
| WP | WP:WP2380 | Brain derived neurotrophic factor BDNF signaling | Brain derived neurotrophic factor BDNF signaling | 10 | 9.724643e-05 | 0 |
| WP | WP:WP5353 | Macrophage stimulating protein MSP signaling | Macrophage stimulating protein MSP signaling | 9 | 1.224634e-04 | 0 |
| WP | WP:WP4016 | DNA IR damage and cellular response via ATR | DNA IR damage and cellular response via ATR | 8 | 1.448046e-04 | 0 |
| WP | WP:WP4754 | IL18 signaling | IL18 signaling | 7 | 1.461038e-04 | 0 |
| WP | WP:WP5331 | Autophagy in pancreatic ductal adenocarcinoma | Autophagy in pancreatic ductal adenocarcinoma | 5 | 1.653572e-04 | 0 |
| WP | WP:WP254 | Apoptosis | Apoptosis | 8 | 2.514151e-04 | 0 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 16 | 3.402415e-04 | 0 |
| WP | WP:WP2355 | Corticotropin releasing hormone signaling | Corticotropin releasing hormone signaling | 8 | 3.547818e-04 | 0 |
| WP | WP:WP706 | Sudden infant death syndrome SIDS susceptibility pathways | Sudden infant death syndrome SIDS susceptibility pathways | 10 | 3.829192e-04 | 0 |
| WP | WP:WP5049 | Glycolysis in senescence | Glycolysis in senescence | 4 | 4.192610e-04 | 0 |
| WP | WP:WP3303 | RAC1 PAK1 p38 MMP2 pathway | RAC1 PAK1 p38 MMP2 pathway | 7 | 5.580155e-04 | 0 |
| WP | WP:WP2037 | Prolactin signaling | Prolactin signaling | 7 | 9.901424e-04 | 0 |
| WP | WP:WP3286 | Copper homeostasis | Copper homeostasis | 6 | 1.349349e-03 | 0 |
| WP | WP:WP710 | DNA damage response only ATM dependent | DNA damage response only ATM dependent | 8 | 1.384377e-03 | 0 |
| WP | WP:WP2864 | Apoptosis related network due to altered Notch3 in ovarian cancer | Apoptosis related network due to altered Notch3 in ovarian cancer | 6 | 1.694621e-03 | 0 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 8 | 1.809208e-03 | 0 |
| WP | WP:WP1984 | Integrated breast cancer pathway | Integrated breast cancer pathway | 9 | 2.104647e-03 | 0 |
| WP | WP:WP3959 | DNA IR double strand breaks and cellular response via ATM | DNA IR double strand breaks and cellular response via ATM | 6 | 2.108228e-03 | 0 |
| WP | WP:WP2272 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 6 | 2.108228e-03 | 0 |
| WP | WP:WP3646 | Hepatitis C and hepatocellular carcinoma | Hepatitis C and hepatocellular carcinoma | 6 | 2.343683e-03 | 0 |
| WP | WP:WP138 | Androgen receptor signaling | Androgen receptor signaling | 7 | 2.500178e-03 | 0 |
| WP | WP:WP382 | MAPK signaling | MAPK signaling | 11 | 2.983645e-03 | 0 |
| WP | WP:WP5381 | Smith Magenis and Potocki Lupski syndrome copy number variation | Smith Magenis and Potocki Lupski syndrome copy number variation | 9 | 3.025991e-03 | 0 |
| WP | WP:WP5098 | T cell activation SARS CoV 2 | T cell activation SARS CoV 2 | 7 | 3.143952e-03 | 0 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 7 | 3.386787e-03 | 0 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 6 | 5.098761e-03 | 0 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 6 | 7.854502e-03 | 0 |
| WP | WP:WP5158 | Urotensin II mediated signaling | Urotensin II mediated signaling | 6 | 7.854502e-03 | 0 |
| WP | WP:WP5046 | NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence | NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence | 4 | 8.591558e-03 | 0 |
| WP | WP:WP5294 | Sildenafil treatment | Sildenafil treatment | 4 | 8.591558e-03 | 0 |
| WP | WP:WP4141 | PI3K AKT mTOR vitamin D3 signaling | PI3K AKT mTOR vitamin D3 signaling | 4 | 8.591558e-03 | 0 |
| WP | WP:WP712 | Estrogen signaling | Estrogen signaling | 4 | 1.032640e-02 | 0 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 6 | 1.082645e-02 | 0 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 6 | 1.169436e-02 | 0 |
| WP | WP:WP4666 | Hepatitis B infection | Hepatitis B infection | 8 | 1.543358e-02 | 0 |
| WP | WP:WP3658 | Wnt beta catenin signaling in leukemia | Wnt beta catenin signaling in leukemia | 4 | 1.706530e-02 | 0 |
| WP | WP:WP2018 | RANKL RANK signaling | RANKL RANK signaling | 5 | 1.813306e-02 | 0 |
| WP | WP:WP4747 | Netrin UNC5B signaling | Netrin UNC5B signaling | 5 | 2.191943e-02 | 0 |
| WP | WP:WP3875 | ATR signaling | ATR signaling | 3 | 2.311831e-02 | 0 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 7 | 2.316597e-02 | 0 |
| WP | WP:WP195 | IL1 signaling | IL1 signaling | 5 | 2.628475e-02 | 0 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 10 | 2.731527e-02 | 0 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 10 | 3.192574e-02 | 0 |
| WP | WP:WP673 | ErbB signaling | ErbB signaling | 6 | 3.281076e-02 | 0 |
| WP | WP:WP231 | TNF alpha signaling | TNF alpha signaling | 6 | 3.281076e-02 | 0 |
| WP | WP:WP2839 | Hair follicle development organogenesis stage 2 of 3 | Hair follicle development organogenesis stage 2 of 3 | 4 | 3.933107e-02 | 0 |
| WP | WP:WP2112 | IL17 signaling | IL17 signaling | 4 | 3.933107e-02 | 0 |
| WP | WP:WP23 | B cell receptor signaling | B cell receptor signaling | 6 | 3.937379e-02 | 0 |
| WP | WP:WP4628 | Aerobic glycolysis augmented | Aerobic glycolysis augmented | 3 | 3.953251e-02 | 0 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 14 | 4.112795e-02 | 0 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 6 | 4.693187e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-3371556 | Cellular response to heat stress | Cellular response to heat stress | 14 | 5.798634e-13 | 0 |
| REAC | REAC:R-HSA-3371511 | HSF1 activation | HSF1 activation | 8 | 1.133179e-12 | 0 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 43 | 2.620460e-11 | 0 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 32 | 2.741566e-10 | 0 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 28 | 3.127371e-10 | 0 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 28 | 4.791985e-10 | 0 |
| REAC | REAC:R-HSA-9613829 | Chaperone Mediated Autophagy | Chaperone Mediated Autophagy | 7 | 5.437354e-08 | 0 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 26 | 1.085601e-07 | 0 |
| REAC | REAC:R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | Regulation of HSF1-mediated heat shock response | 9 | 4.721639e-07 | 0 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 39 | 6.376835e-07 | 0 |
| REAC | REAC:R-HSA-9663891 | Selective autophagy | Selective autophagy | 9 | 2.371171e-06 | 0 |
| REAC | REAC:R-HSA-9612973 | Autophagy | Autophagy | 11 | 4.037721e-06 | 0 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 28 | 8.606209e-06 | 0 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 22 | 1.007616e-05 | 0 |
| REAC | REAC:R-HSA-9646399 | Aggrephagy | Aggrephagy | 7 | 1.072956e-05 | 0 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 37 | 1.313338e-05 | 0 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 12 | 1.322239e-05 | 0 |
| REAC | REAC:R-HSA-449147 | Signaling by Interleukins | Signaling by Interleukins | 17 | 1.874664e-05 | 0 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 10 | 2.714726e-05 | 0 |
| REAC | REAC:R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translation | Respiratory syncytial virus (RSV) genome replication, transcription and translation | 5 | 3.030519e-05 | 0 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 16 | 4.381482e-05 | 0 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 30 | 5.169128e-05 | 0 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 28 | 6.470430e-05 | 0 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 29 | 7.273569e-05 | 0 |
| REAC | REAC:R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | Regulation of mRNA stability by proteins that bind AU-rich elements | 8 | 7.838114e-05 | 0 |
| REAC | REAC:R-HSA-110320 | Translesion Synthesis by POLH | Translesion Synthesis by POLH | 5 | 7.929097e-05 | 0 |
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 11 | 9.293693e-05 | 0 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 9 | 1.118064e-04 | 0 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 19 | 1.266880e-04 | 0 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 11 | 1.309488e-04 | 0 |
| REAC | REAC:R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 6 | 1.373660e-04 | 0 |
| REAC | REAC:R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins | SUMO E3 ligases SUMOylate target proteins | 10 | 1.873378e-04 | 0 |
| REAC | REAC:R-HSA-9824439 | Bacterial Infection Pathways | Bacterial Infection Pathways | 7 | 1.915097e-04 | 0 |
| REAC | REAC:R-HSA-1632852 | Macroautophagy | Macroautophagy | 9 | 2.166363e-04 | 0 |
| REAC | REAC:R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | Deactivation of the beta-catenin transactivating complex | 6 | 2.170186e-04 | 0 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 19 | 2.512031e-04 | 0 |
| REAC | REAC:R-HSA-2990846 | SUMOylation | SUMOylation | 10 | 2.570968e-04 | 0 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 39 | 2.976108e-04 | 0 |
| REAC | REAC:R-HSA-73893 | DNA Damage Bypass | DNA Damage Bypass | 6 | 4.901578e-04 | 0 |
| REAC | REAC:R-HSA-5689877 | Josephin domain DUBs | Josephin domain DUBs | 4 | 4.998234e-04 | 0 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 10 | 6.203354e-04 | 0 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 12 | 6.433582e-04 | 0 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 10 | 6.801681e-04 | 0 |
| REAC | REAC:R-HSA-209560 | NF-kB is activated and signals survival | NF-kB is activated and signals survival | 4 | 7.179293e-04 | 0 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 16 | 7.535400e-04 | 0 |
| REAC | REAC:R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | Respiratory Syncytial Virus Infection Pathway | 8 | 9.528919e-04 | 0 |
| REAC | REAC:R-HSA-5633007 | Regulation of TP53 Activity | Regulation of TP53 Activity | 9 | 9.587126e-04 | 0 |
| REAC | REAC:R-HSA-3371568 | Attenuation phase | Attenuation phase | 4 | 9.994805e-04 | 0 |
| REAC | REAC:R-HSA-5213460 | RIPK1-mediated regulated necrosis | RIPK1-mediated regulated necrosis | 5 | 1.081180e-03 | 0 |
| REAC | REAC:R-HSA-5675482 | Regulation of necroptotic cell death | Regulation of necroptotic cell death | 5 | 1.081180e-03 | 0 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 7 | 1.085081e-03 | 0 |
| REAC | REAC:R-HSA-5656169 | Termination of translesion DNA synthesis | Termination of translesion DNA synthesis | 5 | 1.274037e-03 | 0 |
| REAC | REAC:R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | 6 | 1.375117e-03 | 0 |
| REAC | REAC:R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | Signaling by ALK fusions and activated point mutants | 7 | 1.479424e-03 | 0 |
| REAC | REAC:R-HSA-9700206 | Signaling by ALK in cancer | Signaling by ALK in cancer | 7 | 1.479424e-03 | 0 |
| REAC | REAC:R-HSA-5218859 | Regulated Necrosis | Regulated Necrosis | 6 | 1.524841e-03 | 0 |
| REAC | REAC:R-HSA-193639 | p75NTR signals via NF-kB | p75NTR signals via NF-kB | 4 | 1.796975e-03 | 0 |
| REAC | REAC:R-HSA-110312 | Translesion synthesis by REV1 | Translesion synthesis by REV1 | 4 | 1.796975e-03 | 0 |
| REAC | REAC:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Regulation of TP53 Activity through Phosphorylation | 7 | 1.848017e-03 | 0 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 11 | 2.005563e-03 | 0 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 14 | 2.151328e-03 | 0 |
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 7 | 2.290121e-03 | 0 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 7 | 2.290121e-03 | 0 |
| REAC | REAC:R-HSA-6804757 | Regulation of TP53 Degradation | Regulation of TP53 Degradation | 5 | 2.330778e-03 | 0 |
| REAC | REAC:R-HSA-5656121 | Translesion synthesis by POLI | Translesion synthesis by POLI | 4 | 2.336757e-03 | 0 |
| REAC | REAC:R-HSA-5655862 | Translesion synthesis by POLK | Translesion synthesis by POLK | 4 | 2.336757e-03 | 0 |
| REAC | REAC:R-HSA-8876725 | Protein methylation | Protein methylation | 4 | 2.336757e-03 | 0 |
| REAC | REAC:R-HSA-6806003 | Regulation of TP53 Expression and Degradation | Regulation of TP53 Expression and Degradation | 5 | 2.679488e-03 | 0 |
| REAC | REAC:R-HSA-5336415 | Uptake and function of diphtheria toxin | Uptake and function of diphtheria toxin | 3 | 2.931799e-03 | 0 |
| REAC | REAC:R-HSA-5689896 | Ovarian tumor domain proteases | Ovarian tumor domain proteases | 5 | 3.498696e-03 | 0 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 22 | 3.609868e-03 | 0 |
| REAC | REAC:R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | Toll Like Receptor 3 (TLR3) Cascade | 7 | 3.917173e-03 | 0 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 12 | 4.361151e-03 | 0 |
| REAC | REAC:R-HSA-5696400 | Dual Incision in GG-NER | Dual Incision in GG-NER | 5 | 4.501732e-03 | 0 |
| REAC | REAC:R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | TRIF (TICAM1)-mediated TLR4 signaling | 7 | 5.035155e-03 | 0 |
| REAC | REAC:R-HSA-166166 | MyD88-independent TLR4 cascade | MyD88-independent TLR4 cascade | 7 | 5.035155e-03 | 0 |
| REAC | REAC:R-HSA-5696395 | Formation of Incision Complex in GG-NER | Formation of Incision Complex in GG-NER | 5 | 5.716275e-03 | 0 |
| REAC | REAC:R-HSA-9818749 | Regulation of NFE2L2 gene expression | Regulation of NFE2L2 gene expression | 3 | 8.122050e-03 | 0 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 9 | 8.707122e-03 | 0 |
| REAC | REAC:R-HSA-3371571 | HSF1-dependent transactivation | HSF1-dependent transactivation | 4 | 1.003179e-02 | 0 |
| REAC | REAC:R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6 | 1.146537e-02 | 0 |
| REAC | REAC:R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | Gap-filling DNA repair synthesis and ligation in GG-NER | 4 | 1.187595e-02 | 0 |
| REAC | REAC:R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | Constitutive Signaling by AKT1 E17K in Cancer | 4 | 1.187595e-02 | 0 |
| REAC | REAC:R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4 | 1.187595e-02 | 0 |
| REAC | REAC:R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | Global Genome Nucleotide Excision Repair (GG-NER) | 6 | 1.315490e-02 | 0 |
| REAC | REAC:R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | Formation of tubulin folding intermediates by CCT/TriC | 4 | 1.395688e-02 | 0 |
| REAC | REAC:R-HSA-5218920 | VEGFR2 mediated vascular permeability | VEGFR2 mediated vascular permeability | 4 | 1.629274e-02 | 0 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 8 | 1.684795e-02 | 0 |
| REAC | REAC:R-HSA-390450 | Folding of actin by CCT/TriC | Folding of actin by CCT/TriC | 3 | 1.722007e-02 | 0 |
| REAC | REAC:R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | Prefoldin mediated transfer of substrate to CCT/TriC | 4 | 1.890215e-02 | 0 |
| REAC | REAC:R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 5 | 1.928056e-02 | 0 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 10 | 2.044146e-02 | 0 |
| REAC | REAC:R-HSA-9834752 | Respiratory syncytial virus genome replication | Respiratory syncytial virus genome replication | 2 | 2.074405e-02 | 0 |
| REAC | REAC:R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | Assembly and release of respiratory syncytial virus (RSV) virions | 2 | 2.074405e-02 | 0 |
| REAC | REAC:R-HSA-170834 | Signaling by TGF-beta Receptor Complex | Signaling by TGF-beta Receptor Complex | 6 | 2.202386e-02 | 0 |
| REAC | REAC:R-HSA-69473 | G2/M DNA damage checkpoint | G2/M DNA damage checkpoint | 6 | 2.485608e-02 | 0 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 4 | 2.501837e-02 | 0 |
| REAC | REAC:R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | Recognition of DNA damage by PCNA-containing replication complex | 4 | 2.501837e-02 | 0 |
| REAC | REAC:R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | Toll Like Receptor 5 (TLR5) Cascade | 6 | 2.637739e-02 | 0 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 6 | 2.637739e-02 | 0 |
| REAC | REAC:R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | Toll Like Receptor 10 (TLR10) Cascade | 6 | 2.637739e-02 | 0 |
| REAC | REAC:R-HSA-975871 | MyD88 cascade initiated on plasma membrane | MyD88 cascade initiated on plasma membrane | 6 | 2.637739e-02 | 0 |
| REAC | REAC:R-HSA-9614399 | Regulation of localization of FOXO transcription factors | Regulation of localization of FOXO transcription factors | 3 | 3.123598e-02 | 0 |
| REAC | REAC:R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 3 | 3.123598e-02 | 0 |
| REAC | REAC:R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | Toll Like Receptor 4 (TLR4) Cascade | 7 | 3.264582e-02 | 0 |
| REAC | REAC:R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6 | 3.513847e-02 | 0 |
| REAC | REAC:R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4 | 3.673505e-02 | 0 |
| REAC | REAC:R-HSA-975155 | MyD88 dependent cascade initiated on endosome | MyD88 dependent cascade initiated on endosome | 6 | 3.714043e-02 | 0 |
| REAC | REAC:R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6 | 3.923218e-02 | 0 |
| REAC | REAC:R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | Cytosolic sensors of pathogen-associated DNA | 5 | 4.012831e-02 | 0 |
| REAC | REAC:R-HSA-9615710 | Late endosomal microautophagy | Late endosomal microautophagy | 4 | 4.140102e-02 | 0 |
| REAC | REAC:R-HSA-5617833 | Cilium Assembly | Cilium Assembly | 8 | 4.145039e-02 | 0 |
| REAC | REAC:R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | Toll Like Receptor 9 (TLR9) Cascade | 6 | 4.607546e-02 | 0 |
| REAC | REAC:R-HSA-9706574 | RHOBTB GTPase Cycle | RHOBTB GTPase Cycle | 4 | 4.648261e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 10 | 4.264444e-07 | 0 |
| KEGG | KEGG:05134 | Legionellosis | Legionellosis | 8 | 1.174462e-06 | 0 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | Lipid and atherosclerosis | 13 | 1.234421e-06 | 0 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 12 | 5.708976e-06 | 0 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 17 | 1.505400e-05 | 0 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 10 | 3.815062e-05 | 0 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 12 | 5.847911e-05 | 0 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 9 | 1.137896e-04 | 0 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | Fluid shear stress and atherosclerosis | 9 | 1.368144e-04 | 0 |
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 9 | 3.987412e-04 | 0 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 9 | 4.200731e-04 | 0 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 9 | 5.155022e-04 | 0 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 11 | 7.522381e-04 | 0 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | IL-17 signaling pathway | 7 | 7.657503e-04 | 0 |
| KEGG | KEGG:05162 | Measles | Measles | 8 | 1.283684e-03 | 0 |
| KEGG | KEGG:04612 | Antigen processing and presentation | Antigen processing and presentation | 6 | 1.606207e-03 | 0 |
| KEGG | KEGG:04137 | Mitophagy - animal | Mitophagy - animal | 7 | 1.612009e-03 | 0 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | Transcriptional misregulation in cancer | 9 | 2.026441e-03 | 0 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 9 | 2.200008e-03 | 0 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 10 | 2.389223e-03 | 0 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 6 | 2.799427e-03 | 0 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | Chemical carcinogenesis - receptor activation | 9 | 4.257419e-03 | 0 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | Thyroid hormone signaling pathway | 7 | 4.568277e-03 | 0 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 8 | 5.284350e-03 | 0 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 9 | 5.486170e-03 | 0 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 6 | 5.643081e-03 | 0 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 14 | 6.502041e-03 | 0 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 9 | 6.536542e-03 | 0 |
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 8 | 6.767754e-03 | 0 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 7 | 7.565011e-03 | 0 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 6 | 8.232835e-03 | 0 |
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 5 | 8.586028e-03 | 0 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | Estrogen signaling pathway | 7 | 9.575879e-03 | 0 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 11 | 1.129391e-02 | 0 |
| KEGG | KEGG:04010 | MAPK signaling pathway | MAPK signaling pathway | 10 | 1.298236e-02 | 0 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 8 | 1.659298e-02 | 0 |
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | Diabetic cardiomyopathy | 8 | 1.902401e-02 | 0 |
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 6 | 1.992204e-02 | 0 |
| KEGG | KEGG:05145 | Toxoplasmosis | Toxoplasmosis | 6 | 1.992204e-02 | 0 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 8 | 2.103322e-02 | 0 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 7 | 2.330971e-02 | 0 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | Neurotrophin signaling pathway | 6 | 3.215955e-02 | 0 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | B cell receptor signaling pathway | 5 | 4.146661e-02 | 0 |
| KEGG | KEGG:04310 | Wnt signaling pathway | Wnt signaling pathway | 7 | 4.343502e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100526 | Neoplasm of the lung | Tumor of the lung. | 8 | 0.000056 | 0 |
| HP | HP:0100606 | Neoplasm of the respiratory system | A tumor (abnormal growth of tissue) of the respiratory system. | 8 | 0.000246 | 0 |
| HP | HP:0030223 | Perseverative thought | The repetitive production of the same response to different commands. | 5 | 0.000653 | 0 |
| HP | HP:0025769 | Disordered formal thought process | An abnormality in the dynamic mode, rate, or form of thought processes as recognized from the flow of ideas expressed in speech. Successive thoughts and speech are easily diverted by external stimuli or internal superficial associations. Unable to maintain a constant train of thought and loose themselves in side issues, losing the thread and are unable to recover it. Superficial connections appear to drive the subject matter. | 6 | 0.000663 | 0 |
| HP | HP:0007373 | Motor neuron atrophy | Wasting involving the motor neuron. | 7 | 0.000985 | 0 |
| HP | HP:0011793 | Neoplasm by anatomical site | Neoplasm categorized according to the anatomical site of origin of the neoplasm. | 22 | 0.001594 | 0 |
| HP | HP:0002380 | Fasciculations | Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units. | 9 | 0.001683 | 0 |
| HP | HP:0002442 | Dyscalculia | A specific learning disability involving mathematics and arithmetic. | 5 | 0.001745 | 0 |
| HP | HP:0100728 | Germ cell neoplasia | Germ cell neoplasia | 6 | 0.001925 | 0 |
| HP | HP:0002366 | Abnormal lower motor neuron morphology | Any structural anomaly of the lower motor neuron. | 5 | 0.002167 | 0 |
| HP | HP:0010785 | Gonadal neoplasm | A tumor (abnormal growth of tissue) of a gonad. | 8 | 0.002368 | 0 |
| HP | HP:0002664 | Neoplasm | An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor). | 22 | 0.002538 | 0 |
| HP | HP:0100615 | Ovarian neoplasm | A tumor (abnormal growth of tissue) of the ovary. | 7 | 0.002990 | 0 |
| HP | HP:0002450 | Abnormal motor neuron morphology | Any structural anomaly that affects the motor neuron. | 7 | 0.003277 | 0 |
| HP | HP:0011960 | Substantia nigra gliosis | Focal proliferation of glial cells in the substantia nigra. | 4 | 0.004070 | 0 |
| HP | HP:0100314 | Cerebral inclusion bodies | Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain. | 6 | 0.004174 | 0 |
| HP | HP:0100315 | Lewy bodies | Lewy bodies | 5 | 0.004724 | 0 |
| HP | HP:0010787 | Genital neoplasm | A tumor (abnormal growth of tissue) of the genital system. | 9 | 0.005114 | 0 |
| HP | HP:0100705 | Abnormal glial cell morphology | An abnormality of the glia cell. | 9 | 0.005398 | 0 |
| HP | HP:0012757 | Abnormal neuron morphology | A structural anomaly of a neuron. Neurons are electrically excitable cells that transmit signals throughout the body. Neurons employ both electrical and chemical components in the transmission of information. Neurons are connected to other neurons at synapses and connected to effector organs or cells at neuroeffector junctions. | 7 | 0.006007 | 0 |
| HP | HP:0010788 | Testicular neoplasm | The presence of a neoplasm of the testis. | 5 | 0.009209 | 0 |
| HP | HP:0010936 | Abnormality of the lower urinary tract | An abnormality of the lower urinary tract. | 20 | 0.009376 | 0 |
| HP | HP:0100848 | Neoplasm of the male external genitalia | A tumor (abnormal growth of tissue) of the male external genitalia. | 5 | 0.010729 | 0 |
| HP | HP:0100242 | Sarcoma | A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. | 9 | 0.011057 | 0 |
| HP | HP:0002669 | Osteosarcoma | A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. | 5 | 0.016495 | 0 |
| HP | HP:0100006 | Neoplasm of the central nervous system | A neoplasm of the central nervous system. | 9 | 0.017713 | 0 |
| HP | HP:0002171 | Gliosis | Gliosis is the focal proliferation of glial cells in the central nervous system. | 7 | 0.021147 | 0 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 10 | 0.022274 | 0 |
| HP | HP:0000008 | Abnormal morphology of female internal genitalia | An abnormality of the female internal genitalia. | 14 | 0.025469 | 0 |
| HP | HP:0006774 | Ovarian papillary adenocarcinoma | The presence of a papillary adenocarcinoma of the ovary. | 3 | 0.026104 | 0 |
| HP | HP:0002362 | Shuffling gait | A type of gait (walking) characterized by by dragging one's feet along or without lifting the feet fully from the ground. | 5 | 0.027657 | 0 |
| HP | HP:0000711 | Restlessness | A state of unease is characterized by diffuse motor activity or motion, which is subject to limited control, nonproductive, or disorganized behavior. | 6 | 0.027943 | 0 |
| HP | HP:0004375 | Neoplasm of the nervous system | A tumor (abnormal growth of tissue) of the nervous system. | 9 | 0.036909 | 0 |
| HP | HP:0045007 | Abnormal substantia nigra morphology | A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry. | 4 | 0.039395 | 0 |
| HP | HP:0007190 | Neuronal loss in the cerebral cortex | Neuronal loss in the cerebral cortex | 3 | 0.041520 | 0 |
| HP | HP:0011204 | EEG with continuous slow activity | EEG showing diffuse slowing without interruption. | 3 | 0.041520 | 0 |
| HP | HP:0012657 | Abnormal brain positron emission tomography | A functional brain anomaly detectable by positron emission tomography (PET). PET scanning is a method for functional brain imaging, and its measurements reflect the amount of brain activity in the various regions of the brain. | 4 | 0.047396 | 0 |
| HP | HP:0012658 | Abnormal brain FDG positron emission tomography | An anomaly detectable in [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) brain scans. Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity. | 4 | 0.047396 | 0 |
| HP | HP:0100707 | Abnormal astrocyte morphology | An abnormality of astrocytes. | 5 | 0.049031 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M02090_1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | 53 | 0.000060 | 0 |
| TF | TF:M07039 | Factor: ETF; motif: CCCCGCCCCYN | Factor: ETF; motif: CCCCGCCCCYN | 85 | 0.000665 | 0 |
| TF | TF:M00050 | Factor: E2F; motif: TTTSGCGC | Factor: E2F; motif: TTTSGCGC | 54 | 0.000672 | 0 |
| TF | TF:M09636_1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | 80 | 0.000884 | 0 |
| TF | TF:M08020 | Factor: YY2; motif: NNCCGCCATTW | Factor: YY2; motif: NNCCGCCATTW | 22 | 0.001584 | 0 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 79 | 0.002417 | 0 |
| TF | TF:M00740 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | 67 | 0.002868 | 0 |
| TF | TF:M11601_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 69 | 0.004956 | 0 |
| TF | TF:M03925 | Factor: YY2; motif: NCCGCCATNTY | Factor: YY2; motif: NCCGCCATNTY | 40 | 0.005671 | 0 |
| TF | TF:M11603_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 76 | 0.006125 | 0 |
| TF | TF:M12271 | Factor: ZNF339; motif: NNACCGTTANNNN | Factor: ZNF339; motif: NNACCGTTANNNN | 15 | 0.006425 | 0 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 40 | 0.006672 | 0 |
| TF | TF:M04710_1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | 70 | 0.006900 | 0 |
| TF | TF:M11022_1 | Factor: IRX2a; motif: ACRYGNNNNACRYGT; match class: 1 | Factor: IRX2a; motif: ACRYGNNNNACRYGT; match class: 1 | 48 | 0.007623 | 0 |
| TF | TF:M12597_1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | 64 | 0.008173 | 0 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 66 | 0.009458 | 0 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 66 | 0.009700 | 0 |
| TF | TF:M00940_1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | 28 | 0.009773 | 0 |
| TF | TF:M12554 | Factor: YY2; motif: NNATGGCGGCN | Factor: YY2; motif: NNATGGCGGCN | 28 | 0.010208 | 0 |
| TF | TF:M04797 | Factor: Egr-1; motif: CCGCCCMCG | Factor: Egr-1; motif: CCGCCCMCG | 42 | 0.010542 | 0 |
| TF | TF:M12160 | Factor: KLF15; motif: RCCMCRCCCMCN | Factor: KLF15; motif: RCCMCRCCCMCN | 74 | 0.012485 | 0 |
| TF | TF:M00243 | Factor: Egr-1; motif: WTGCGTGGGCGK | Factor: Egr-1; motif: WTGCGTGGGCGK | 43 | 0.013754 | 0 |
| TF | TF:M04710 | Factor: CHD2; motif: TCTCGCGAG | Factor: CHD2; motif: TCTCGCGAG | 78 | 0.015494 | 0 |
| TF | TF:M03925_1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | 14 | 0.015753 | 0 |
| TF | TF:M02090 | Factor: E2F-4; motif: GCGGGAAANA | Factor: E2F-4; motif: GCGGGAAANA | 71 | 0.019756 | 0 |
| TF | TF:M11654_1 | Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1 | Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1 | 6 | 0.020070 | 0 |
| TF | TF:M07084_1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | 43 | 0.022660 | 0 |
| TF | TF:M04010 | Factor: HSF4; motif: TTCTAGAANNTTC | Factor: HSF4; motif: TTCTAGAANNTTC | 7 | 0.024218 | 0 |
| TF | TF:M02089 | Factor: E2F-3; motif: GGCGGGN | Factor: E2F-3; motif: GGCGGGN | 75 | 0.025493 | 0 |
| TF | TF:M07395 | Factor: Sp1; motif: NGGGGCGGGGN | Factor: Sp1; motif: NGGGGCGGGGN | 66 | 0.025622 | 0 |
| TF | TF:M00986 | Factor: Churchill; motif: CGGGNN | Factor: Churchill; motif: CGGGNN | 78 | 0.030184 | 0 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 83 | 0.030266 | 0 |
| TF | TF:M01199 | Factor: RNF96; motif: BCCCGCRGCC | Factor: RNF96; motif: BCCCGCRGCC | 57 | 0.030493 | 0 |
| TF | TF:M04109 | Factor: RUNX3; motif: NRACCGCAAACCGCAN | Factor: RUNX3; motif: NRACCGCAAACCGCAN | 62 | 0.030797 | 0 |
| TF | TF:M09834 | Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN | Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN | 50 | 0.031796 | 0 |
| TF | TF:M00933 | Factor: Sp1; motif: CCCCGCCCCN | Factor: Sp1; motif: CCCCGCCCCN | 62 | 0.033249 | 0 |
| TF | TF:M02036_1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | 42 | 0.034162 | 0 |
| TF | TF:M01023_1 | Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 1 | Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 1 | 8 | 0.037777 | 0 |
| TF | TF:M03924_1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | 33 | 0.038282 | 0 |
| TF | TF:M07354_1 | Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 | Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 | 33 | 0.038501 | 0 |
| TF | TF:M04519_1 | Factor: E2F-4; motif: TTTGGCGCCAAA; match class: 1 | Factor: E2F-4; motif: TTTGGCGCCAAA; match class: 1 | 26 | 0.040044 | 0 |
| TF | TF:M02036 | Factor: WT1; motif: CGCCCCCNCN | Factor: WT1; motif: CGCCCCCNCN | 62 | 0.040944 | 0 |
| TF | TF:M00333_1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | 72 | 0.043543 | 0 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 80 | 0.047770 | 0 |
| TF | TF:M00738 | Factor: E2F-4:DP-1; motif: TTTSGCGC | Factor: E2F-4:DP-1; motif: TTTSGCGC | 62 | 0.048364 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1332 | Large Drosha complex | Large Drosha complex | 6 | 0.000151 | 0 |
| CORUM | CORUM:5199 | Kinase maturation complex 1 | Kinase maturation complex 1 | 5 | 0.001041 | 0 |
| CORUM | CORUM:3135 | TLE1 corepressor complex (MASH1 promoter-corepressor complex) | TLE1 corepressor complex (MASH1 promoter-corepressor complex) | 4 | 0.001058 | 0 |
| CORUM | CORUM:1729 | TLE1 corepressor complex (MASH1 promoter-corepressor complex) | TLE1 corepressor complex (MASH1 promoter-corepressor complex) | 4 | 0.003085 | 0 |
| CORUM | CORUM:3082 | DGCR8 multiprotein complex | DGCR8 multiprotein complex | 4 | 0.003085 | 0 |
| CORUM | CORUM:5423 | HSP70-BAG5-PARK2 complex | HSP70-BAG5-PARK2 complex | 3 | 0.003554 | 0 |
| CORUM | CORUM:1335 | SNW1 complex | SNW1 complex | 4 | 0.018697 | 0 |
| CORUM | CORUM:2721 | HCF-1 complex | HCF-1 complex | 4 | 0.024582 | 0 |
| CORUM | CORUM:126 | CCT complex (chaperonin containing TCP1 complex) | CCT complex (chaperonin containing TCP1 complex) | 3 | 0.047164 | 0 |
| CORUM | CORUM:7284 | GSK3B-HSP90AA1-PKM2 complex | GSK3B-HSP90AA1-PKM2 complex | 2 | 0.049911 | 0 |
| CORUM | CORUM:1816 | JUN-TCF4-CTNNB1 complex | JUN-TCF4-CTNNB1 complex | 2 | 0.049911 | 0 |
| CORUM | CORUM:2156 | YBX1-AKT1 complex | YBX1-AKT1 complex | 2 | 0.049911 | 0 |
| CORUM | CORUM:5229 | RPA complex | RPA complex | 2 | 0.049911 | 0 |
| CORUM | CORUM:5331 | YY1-MDM2-p53 complex | YY1-MDM2-p53 complex | 2 | 0.049911 | 0 |
| CORUM | CORUM:5718 | NOS3-HSP90-AKT complex, VEGF induced | NOS3-HSP90-AKT complex, VEGF induced | 2 | 0.049911 | 0 |
| CORUM | CORUM:6412 | AURKA-HDAC6 cilia-disassembly complex | AURKA-HDAC6 cilia-disassembly complex | 2 | 0.049911 | 0 |
| CORUM | CORUM:7180 | p53-MDM2 complex | p53-MDM2 complex | 2 | 0.049911 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0022626 | cytosolic ribosome | "A ribosome located in the cytosol." [GOC:mtg_sensu] | 28 | 7.093667e-52 | 1 |
| GO:CC | GO:0044391 | ribosomal subunit | "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl] | 28 | 2.357215e-45 | 1 |
| GO:CC | GO:0005840 | ribosome | "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] | 28 | 2.635535e-32 | 1 |
| GO:CC | GO:0022627 | cytosolic small ribosomal subunit | "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 15 | 6.482250e-29 | 1 |
| GO:CC | GO:0015935 | small ribosomal subunit | "The smaller of the two subunits of a ribosome." [GOC:mah] | 15 | 1.787087e-24 | 1 |
| GO:CC | GO:0022625 | cytosolic large ribosomal subunit | "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 13 | 4.605922e-22 | 1 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 20 | 1.426608e-20 | 1 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 20 | 2.268136e-20 | 1 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 34 | 5.545587e-20 | 1 |
| GO:CC | GO:0015934 | large ribosomal subunit | "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] | 13 | 1.270358e-17 | 1 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 39 | 1.024869e-15 | 1 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 41 | 3.295980e-15 | 1 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 41 | 3.315538e-15 | 1 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 20 | 4.347500e-14 | 1 |
| GO:CC | GO:0030684 | preribosome | "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] | 10 | 2.835070e-12 | 1 |
| GO:CC | GO:0032040 | small-subunit processome | "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] | 9 | 5.043627e-12 | 1 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 25 | 5.489812e-11 | 1 |
| GO:CC | GO:0005730 | nucleolus | "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] | 21 | 9.175753e-09 | 1 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 19 | 3.323664e-08 | 1 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 37 | 5.331344e-08 | 1 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 31 | 1.656099e-07 | 1 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 27 | 4.259696e-07 | 1 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 43 | 9.972988e-07 | 1 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 32 | 4.213576e-06 | 1 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 32 | 4.213576e-06 | 1 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 32 | 4.213576e-06 | 1 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 8 | 1.026471e-05 | 1 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 8 | 1.774957e-05 | 1 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 45 | 1.487708e-04 | 1 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 36 | 5.082325e-04 | 1 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 45 | 1.276778e-03 | 1 |
| GO:CC | GO:0005791 | rough endoplasmic reticulum | "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] | 4 | 1.619996e-03 | 1 |
| GO:CC | GO:0014069 | postsynaptic density | "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density] | 7 | 1.622840e-03 | 1 |
| GO:CC | GO:0032279 | asymmetric synapse | "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] | 7 | 2.158597e-03 | 1 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 15 | 2.276900e-03 | 1 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 15 | 2.701720e-03 | 1 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 15 | 2.717028e-03 | 1 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 15 | 2.717028e-03 | 1 |
| GO:CC | GO:0099572 | postsynaptic specialization | "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028] | 7 | 3.128450e-03 | 1 |
| GO:CC | GO:0098984 | neuron to neuron synapse | "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos] | 7 | 3.977812e-03 | 1 |
| GO:CC | GO:0010494 | cytoplasmic stress granule | "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] | 4 | 8.644621e-03 | 1 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 45 | 1.727519e-02 | 1 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 11 | 2.619097e-02 | 1 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 8 | 3.489529e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | SRP-dependent cotranslational protein targeting to membrane | 30 | 3.599471e-50 | 1 |
| REAC | REAC:R-HSA-72689 | Formation of a pool of free 40S subunits | Formation of a pool of free 40S subunits | 29 | 3.769070e-49 | 1 |
| REAC | REAC:R-HSA-192823 | Viral mRNA Translation | Viral mRNA Translation | 28 | 2.038482e-48 | 1 |
| REAC | REAC:R-HSA-156902 | Peptide chain elongation | Peptide chain elongation | 28 | 2.038482e-48 | 1 |
| REAC | REAC:R-HSA-2408557 | Selenocysteine synthesis | Selenocysteine synthesis | 28 | 8.585594e-48 | 1 |
| REAC | REAC:R-HSA-156842 | Eukaryotic Translation Elongation | Eukaryotic Translation Elongation | 28 | 8.585594e-48 | 1 |
| REAC | REAC:R-HSA-72764 | Eukaryotic Translation Termination | Eukaryotic Translation Termination | 28 | 8.585594e-48 | 1 |
| REAC | REAC:R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | L13a-mediated translational silencing of Ceruloplasmin expression | 29 | 8.676766e-48 | 1 |
| REAC | REAC:R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | GTP hydrolysis and joining of the 60S ribosomal subunit | 29 | 1.165989e-47 | 1 |
| REAC | REAC:R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 28 | 1.714675e-47 | 1 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 29 | 8.505866e-47 | 1 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 29 | 8.505866e-47 | 1 |
| REAC | REAC:R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Response of EIF2AK4 (GCN2) to amino acid deficiency | 28 | 1.237781e-46 | 1 |
| REAC | REAC:R-HSA-927802 | Nonsense-Mediated Decay (NMD) | Nonsense-Mediated Decay (NMD) | 28 | 7.665806e-45 | 1 |
| REAC | REAC:R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 28 | 7.665806e-45 | 1 |
| REAC | REAC:R-HSA-2408522 | Selenoamino acid metabolism | Selenoamino acid metabolism | 28 | 1.006591e-44 | 1 |
| REAC | REAC:R-HSA-168273 | Influenza Viral RNA Transcription and Replication | Influenza Viral RNA Transcription and Replication | 28 | 5.651316e-43 | 1 |
| REAC | REAC:R-HSA-168255 | Influenza Infection | Influenza Infection | 28 | 5.223766e-41 | 1 |
| REAC | REAC:R-HSA-9711097 | Cellular response to starvation | Cellular response to starvation | 28 | 9.423862e-41 | 1 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 28 | 1.266140e-39 | 1 |
| REAC | REAC:R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Major pathway of rRNA processing in the nucleolus and cytosol | 28 | 8.316009e-39 | 1 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 31 | 9.060590e-39 | 1 |
| REAC | REAC:R-HSA-8868773 | rRNA processing in the nucleus and cytosol | rRNA processing in the nucleus and cytosol | 28 | 4.144546e-38 | 1 |
| REAC | REAC:R-HSA-72312 | rRNA processing | rRNA processing | 28 | 1.890481e-37 | 1 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 28 | 1.591019e-36 | 1 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 28 | 5.134539e-30 | 1 |
| REAC | REAC:R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | SARS-CoV-1 modulates host translation machinery | 15 | 6.585218e-26 | 1 |
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 16 | 1.676025e-25 | 1 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 28 | 4.690245e-25 | 1 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 30 | 6.476925e-25 | 1 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 28 | 1.656910e-24 | 1 |
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 16 | 1.747863e-24 | 1 |
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 16 | 1.747863e-24 | 1 |
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 16 | 2.378328e-24 | 1 |
| REAC | REAC:R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | SARS-CoV-2 modulates host translation machinery | 15 | 2.173595e-23 | 1 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 30 | 3.029863e-22 | 1 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 28 | 1.941582e-20 | 1 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 28 | 3.135892e-20 | 1 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 30 | 9.711845e-20 | 1 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 15 | 6.820540e-19 | 1 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 15 | 3.055208e-16 | 1 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 34 | 3.229400e-16 | 1 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 29 | 3.800504e-15 | 1 |
| REAC | REAC:R-HSA-9705683 | SARS-CoV-2-host interactions | SARS-CoV-2-host interactions | 15 | 5.684631e-14 | 1 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 30 | 7.411586e-13 | 1 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 15 | 2.012585e-11 | 1 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 29 | 3.081729e-10 | 1 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 16 | 9.466154e-10 | 1 |
| REAC | REAC:R-HSA-9629569 | Protein hydroxylation | Protein hydroxylation | 4 | 2.850613e-04 | 1 |
| REAC | REAC:R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4 | 2.576289e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP477 | Cytoplasmic ribosomal proteins | Cytoplasmic ribosomal proteins | 28 | 6.251443e-48 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 29 | 7.144871e-48 | 1 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 32 | 7.892229e-34 | 1 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 38 | 3.004721e-15 | 1 |
| GO:BP | GO:0042254 | ribosome biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] | 16 | 5.314733e-15 | 1 |
| GO:BP | GO:0042274 | ribosomal small subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 11 | 4.115489e-13 | 1 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 41 | 6.033305e-08 | 1 |
| GO:BP | GO:0006364 | rRNA processing | "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] | 10 | 6.863752e-08 | 1 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 41 | 3.260202e-07 | 1 |
| GO:BP | GO:0016072 | rRNA metabolic process | "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] | 10 | 3.549158e-07 | 1 |
| GO:BP | GO:0042255 | ribosome assembly | "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428] | 6 | 7.804684e-06 | 1 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 41 | 1.423504e-05 | 1 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 42 | 1.526907e-04 | 1 |
| GO:BP | GO:0022613 | ribonucleoprotein complex biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] | 17 | 1.952904e-04 | 1 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 42 | 3.831726e-04 | 1 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 9 | 4.920150e-04 | 1 |
| GO:BP | GO:0000028 | ribosomal small subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl, PMID:30467428] | 3 | 1.353499e-02 | 1 |
| GO:BP | GO:0042273 | ribosomal large subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 4 | 2.803410e-02 | 1 |
| GO:BP | GO:0034101 | erythrocyte homeostasis | "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] | 5 | 2.817877e-02 | 1 |
| GO:BP | GO:0000027 | ribosomal large subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428] | 3 | 3.327173e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03010 | Ribosome | Ribosome | 28 | 3.642746e-40 | 1 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | Coronavirus disease - COVID-19 | 28 | 8.606612e-35 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:306 | Ribosome, cytoplasmic | Ribosome, cytoplasmic | 26 | 1.058173e-36 | 1 |
| CORUM | CORUM:3055 | Nop56p-associated pre-rRNA complex | Nop56p-associated pre-rRNA complex | 22 | 2.743274e-25 | 1 |
| CORUM | CORUM:338 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 14 | 1.098340e-19 | 1 |
| CORUM | CORUM:305 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 14 | 3.715768e-19 | 1 |
| CORUM | CORUM:308 | 60S ribosomal subunit, cytoplasmic | 60S ribosomal subunit, cytoplasmic | 12 | 5.315584e-13 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003735 | structural constituent of ribosome | "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] | 28 | 8.080997e-33 | 1 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 40 | 4.928311e-25 | 1 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 28 | 7.131473e-22 | 1 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 41 | 7.452444e-17 | 1 |
| GO:MF | GO:0019843 | rRNA binding | "Binding to a ribosomal RNA." [GOC:jl] | 7 | 7.127824e-08 | 1 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 7 | 1.096532e-02 | 1 |
| GO:MF | GO:0070180 | large ribosomal subunit rRNA binding | "Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh] | 2 | 2.381282e-02 | 1 |
| GO:MF | GO:0055106 | ubiquitin-protein transferase regulator activity | "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] | 3 | 2.645042e-02 | 1 |
| GO:MF | GO:0008312 | 7S RNA binding | "Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418] | 2 | 4.986546e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0012133 | Erythroid hypoplasia | Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 8 | 6.096014e-12 | 1 |
| HP | HP:0030270 | Elevated red cell adenosine deaminase activity | Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine. | 7 | 3.229845e-10 | 1 |
| HP | HP:0031640 | Abnormal radial artery morphology | Any structural anomaly of the radial artery. | 7 | 3.229845e-10 | 1 |
| HP | HP:0020118 | Radial artery aplasia | Congenital absence of the radial artery. | 7 | 3.229845e-10 | 1 |
| HP | HP:4000209 | Abnormal erythrocyte adenosine deaminase activity | Activity of adenosine deaminase in red blood cells outside the limits of normal. | 7 | 4.354257e-10 | 1 |
| HP | HP:0012131 | Abnormal number of erythroid precursors | A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 8 | 5.666464e-10 | 1 |
| HP | HP:0005532 | Macrocytic dyserythropoietic anemia | Macrocytic dyserythropoietic anemia | 7 | 5.797640e-10 | 1 |
| HP | HP:0012410 | Pure red cell aplasia | A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction. | 7 | 9.940694e-10 | 1 |
| HP | HP:0040276 | Adenocarcinoma of the colon | Adenocarcinoma of the colon | 7 | 3.260866e-09 | 1 |
| HP | HP:0001227 | Abnormality of the thenar eminence | An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb. | 7 | 3.260866e-09 | 1 |
| HP | HP:0006758 | Malignant genitourinary tract tumor | The presence of a malignant neoplasm of the genital system. | 7 | 4.042362e-09 | 1 |
| HP | HP:0001894 | Thrombocytosis | Increased numbers of platelets in the peripheral blood. | 8 | 4.250505e-09 | 1 |
| HP | HP:0011904 | Persistence of hemoglobin F | Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent. | 7 | 4.978670e-09 | 1 |
| HP | HP:0001896 | Reticulocytopenia | A reduced number of reticulocytes in the peripheral blood. | 7 | 4.978670e-09 | 1 |
| HP | HP:0002669 | Osteosarcoma | A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. | 7 | 4.978670e-09 | 1 |
| HP | HP:0002863 | Myelodysplasia | Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia. | 9 | 5.856993e-09 | 1 |
| HP | HP:0001895 | Normochromic anemia | Normochromic anemia | 7 | 7.417283e-09 | 1 |
| HP | HP:0040275 | Adenocarcinoma of the large intestine | A malignant epithelial tumor with a glandular organization that originates in the large intestine. | 7 | 7.417283e-09 | 1 |
| HP | HP:0001972 | Macrocytic anemia | A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH). | 8 | 1.104349e-08 | 1 |
| HP | HP:0009944 | Partial duplication of thumb phalanx | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 7 | 1.295594e-08 | 1 |
| HP | HP:0004808 | Acute myeloid leukemia | A form of leukemia characterized by overproduction of an early myeloid cell. | 8 | 1.378224e-08 | 1 |
| HP | HP:0040273 | Adenocarcinoma of the intestines | A malignant epithelial tumor with a glandular organization that originates in the intestines. | 7 | 1.545368e-08 | 1 |
| HP | HP:0009999 | Partial duplication of the phalanx of hand | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 7 | 1.835185e-08 | 1 |
| HP | HP:0030272 | Abnormal erythrocyte enzyme concentration or activity | An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme. | 7 | 4.085335e-08 | 1 |
| HP | HP:0005518 | Increased mean corpuscular volume | Larger than normal size of erythrocytes. | 7 | 6.336167e-08 | 1 |
| HP | HP:0000912 | Sprengel anomaly | A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other). | 7 | 8.364361e-08 | 1 |
| HP | HP:0009777 | Absent thumb | Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues. | 7 | 1.412187e-07 | 1 |
| HP | HP:0009942 | Duplication of thumb phalanx | Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits. | 7 | 1.808870e-07 | 1 |
| HP | HP:0000185 | Cleft soft palate | Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency. | 7 | 1.808870e-07 | 1 |
| HP | HP:0025065 | Abnormal mean corpuscular volume | A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters. | 7 | 2.297012e-07 | 1 |
| HP | HP:0001790 | Nonimmune hydrops fetalis | A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens . | 7 | 3.617250e-07 | 1 |
| HP | HP:0002488 | Acute leukemia | A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). | 8 | 5.433322e-07 | 1 |
| HP | HP:0001199 | Triphalangeal thumb | A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb. | 7 | 5.537005e-07 | 1 |
| HP | HP:0009778 | Short thumb | Hypoplasia (congenital reduction in size) of the thumb. | 8 | 8.625263e-07 | 1 |
| HP | HP:0001087 | Developmental glaucoma | Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma. | 7 | 9.103996e-07 | 1 |
| HP | HP:0006749 | Malignant gastrointestinal tract tumors | Malignant gastrointestinal tract tumors | 7 | 9.103996e-07 | 1 |
| HP | HP:0002672 | Gastrointestinal carcinoma | Gastrointestinal carcinoma | 7 | 9.103996e-07 | 1 |
| HP | HP:0011902 | Abnormal hemoglobin | Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes. | 7 | 1.099961e-06 | 1 |
| HP | HP:0100273 | Neoplasm of the colon | Neoplasm of the colon | 7 | 1.726829e-06 | 1 |
| HP | HP:0004312 | Abnormal reticulocyte morphology | A reticulocyte abnormality. | 7 | 2.051583e-06 | 1 |
| HP | HP:0009601 | Aplasia/Hypoplasia of the thumb | Hypoplastic/small or absent thumb. | 8 | 3.320793e-06 | 1 |
| HP | HP:0000294 | Low anterior hairline | Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella. | 8 | 3.503476e-06 | 1 |
| HP | HP:0000085 | Horseshoe kidney | A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline. | 8 | 3.694830e-06 | 1 |
| HP | HP:0009380 | Finger aplasia | A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers). | 7 | 3.923973e-06 | 1 |
| HP | HP:0000980 | Pallor | Abnormally pale skin. | 8 | 4.554050e-06 | 1 |
| HP | HP:0001882 | Decreased total leukocyte count | An abnormal decreased number of leukocytes in the blood. | 8 | 5.581811e-06 | 1 |
| HP | HP:0010622 | Neoplasm of the skeletal system | A tumor (abnormal growth of tissue) of the skeleton. | 7 | 1.001094e-05 | 1 |
| HP | HP:0001909 | Leukemia | A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. | 8 | 1.043942e-05 | 1 |
| HP | HP:0001874 | Abnormality of neutrophils | A neutrophil abnormality. | 9 | 1.373578e-05 | 1 |
| HP | HP:0100834 | Neoplasm of the large intestine | The presence of a neoplasm of the large intestine. | 7 | 1.900234e-05 | 1 |
| HP | HP:0004377 | Hematological neoplasm | Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). | 9 | 3.212018e-05 | 1 |
| HP | HP:0000465 | Webbed neck | Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline. | 7 | 3.223718e-05 | 1 |
| HP | HP:0010972 | Anemia of inadequate production | A kind of anemia characterized by inadequate production of erythrocytes. | 8 | 3.585778e-05 | 1 |
| HP | HP:0001789 | Hydrops fetalis | The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema. | 7 | 3.810650e-05 | 1 |
| HP | HP:0001421 | Abnormality of the musculature of the hand | Abnormality of the musculature of the hand | 7 | 4.025435e-05 | 1 |
| HP | HP:0001875 | Decreased total neutrophil count | Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group. | 8 | 4.877019e-05 | 1 |
| HP | HP:0001911 | Abnormal granulocyte morphology | Any structural abnormality or abnormal count of granulocytes. | 9 | 6.051976e-05 | 1 |
| HP | HP:0000599 | Abnormality of the frontal hairline | An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not. | 8 | 6.794128e-05 | 1 |
| HP | HP:0000519 | Developmental cataract | A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens. | 7 | 8.299628e-05 | 1 |
| HP | HP:0011991 | Abnormal total neutrophil count | A deviation from the normal range of neutrophil cell counts in the circulation. | 8 | 9.659198e-05 | 1 |
| HP | HP:0010974 | Abnormal myeloid leukocyte morphology | An abnormality of myeloid leukocytes. | 9 | 1.239142e-04 | 1 |
| HP | HP:0001680 | Coarctation of aorta | Coarctation of the aorta is a narrowing or constriction of a segment of the aorta. | 7 | 1.457095e-04 | 1 |
| HP | HP:0100542 | Abnormal localization of kidney | An abnormal site of the kidney. | 8 | 1.539541e-04 | 1 |
| HP | HP:0100242 | Sarcoma | A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. | 7 | 2.657563e-04 | 1 |
| HP | HP:0032309 | Abnormal granulocyte count | Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group. | 8 | 3.715379e-04 | 1 |
| HP | HP:0100736 | Abnormal soft palate morphology | An abnormality of the soft palate. | 8 | 3.823062e-04 | 1 |
| HP | HP:0000782 | Abnormal scapula morphology | Any abnormality of the scapula, also known as the shoulder blade. | 7 | 4.607711e-04 | 1 |
| HP | HP:0008551 | Microtia | Underdevelopment of the external ear. | 7 | 6.646620e-04 | 1 |
| HP | HP:0009553 | Abnormality of the hairline | The hairline refers to the outline of hair of the head. An abnormality of the hairline can refer to an unusually low or high border between areas of the scalp with and without hair or to abnormal projections of scalp hair. | 8 | 7.547346e-04 | 1 |
| HP | HP:0009602 | Abnormality of thumb phalanx | A structural anomaly of one or more phalanges of the thumb. | 7 | 9.723069e-04 | 1 |
| HP | HP:0034058 | Abnormal fetal morphology | Any structural anomaly of the fetus. | 8 | 1.103021e-03 | 1 |
| HP | HP:0000104 | Renal agenesis | Agenesis, that is, failure of the kidney to develop during embryogenesis and development. | 7 | 1.147589e-03 | 1 |
| HP | HP:0008772 | Aplasia/Hypoplasia of the external ear | The presence of aplasia or developmental hypoplasia of all or part of the external ear. | 7 | 1.185666e-03 | 1 |
| HP | HP:0011873 | Abnormal platelet count | Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood. | 9 | 1.478463e-03 | 1 |
| HP | HP:0008771 | Aplasia/Hypoplasia of the ear | The presence of aplasia or developmental hypoplasia of the ear. | 7 | 1.483288e-03 | 1 |
| HP | HP:0009381 | Short finger | Abnormally short finger associated with developmental hypoplasia. | 8 | 1.509049e-03 | 1 |
| HP | HP:0011361 | Congenital abnormal hair pattern | A congenital abnormality of the distribution of hair growth. | 8 | 1.581711e-03 | 1 |
| HP | HP:0011875 | Abnormal platelet morphology | An anomaly in platelet form, ultrastructure, or intracellular organelles. | 9 | 1.592839e-03 | 1 |
| HP | HP:0000286 | Epicanthus | A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus. | 10 | 1.614045e-03 | 1 |
| HP | HP:0410030 | Cleft lip | A gap in the lip or lips. | 7 | 1.786350e-03 | 1 |
| HP | HP:0001903 | Anemia | A reduction in erythrocytes volume or hemoglobin concentration. | 10 | 2.021214e-03 | 1 |
| HP | HP:0009997 | Duplication of phalanx of hand | This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated. | 7 | 2.270310e-03 | 1 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 7 | 2.407205e-03 | 1 |
| HP | HP:0004275 | Duplication of hand bones | Duplication of hand bones | 7 | 2.407205e-03 | 1 |
| HP | HP:0009142 | Duplication of bones involving the upper extremities | Duplication of bones involving the upper extremities | 7 | 2.407205e-03 | 1 |
| HP | HP:0001872 | Abnormality of thrombocytes | An abnormality of platelets. | 9 | 2.543381e-03 | 1 |
| HP | HP:0011792 | Neoplasm by histology | Neoplasm categorized according to type of histological abnormality. | 8 | 3.027498e-03 | 1 |
| HP | HP:0001254 | Lethargy | A state of fatigue, either physical or mental slowness and sluggishness, with difficulties in initiating or performing simple tasks. Distinguished from apathy which implies indifference and a lack of desire or interest in the task. A person with lethargy may have the desire, but not the energy to engage in personal or socially relevant tasks. | 7 | 3.673527e-03 | 1 |
| HP | HP:0011893 | Abnormal leukocyte count | Number of leukocytes per volume of blood beyond normal limits. | 9 | 3.701929e-03 | 1 |
| HP | HP:0001629 | Ventricular septal defect | A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum. | 9 | 4.021726e-03 | 1 |
| HP | HP:0000431 | Wide nasal bridge | Increased breadth of the nasal bridge (and with it, the nasal root). | 9 | 4.021726e-03 | 1 |
| HP | HP:0006265 | Aplasia/Hypoplasia of fingers | Small/hypoplastic or absent/aplastic fingers. | 8 | 4.143760e-03 | 1 |
| HP | HP:0010720 | Abnormal hair pattern | An abnormality of the distribution of hair growth. | 8 | 4.586866e-03 | 1 |
| HP | HP:0010438 | Abnormal ventricular septum morphology | A structural abnormality of the interventricular septum. | 9 | 4.811247e-03 | 1 |
| HP | HP:0001877 | Abnormal erythrocyte morphology | Any structural abnormality of erythrocytes (red-blood cells). | 10 | 4.901235e-03 | 1 |
| HP | HP:0001518 | Small for gestational age | Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age. | 7 | 6.677452e-03 | 1 |
| HP | HP:0001172 | Abnormal thumb morphology | An abnormal structure of the first digit of the hand. | 8 | 6.920715e-03 | 1 |
| HP | HP:0001679 | Abnormal aortic morphology | An abnormality of the aorta. | 8 | 8.349362e-03 | 1 |
| HP | HP:0001446 | Abnormality of the musculature of the upper limbs | Abnormality of the musculature of the upper limbs | 7 | 9.580870e-03 | 1 |
| HP | HP:0034057 | Fetal anomaly | Structural or functional abnormalities of the fetus. Note that this section comprises terms that describe abnormalities that are specific to the fetus or differ from the corresponding general terms. A term from anywhere in the Human Phenotype Ontology can be applied to a fetus if appropriate. | 9 | 1.065762e-02 | 1 |
| HP | HP:0001873 | Thrombocytopenia | A reduction in the number of circulating thrombocytes. | 8 | 1.135901e-02 | 1 |
| HP | HP:0000369 | Low-set ears | Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear. | 10 | 1.219192e-02 | 1 |
| HP | HP:0007378 | Neoplasm of the gastrointestinal tract | A tumor (abnormal growth of tissue) of the gastrointestinal tract. | 7 | 1.289066e-02 | 1 |
| HP | HP:0100037 | Abnormality of the scalp hair | An abnormality of the hair of head. | 8 | 1.376487e-02 | 1 |
| HP | HP:0000218 | High palate | Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective). | 10 | 1.599463e-02 | 1 |
| HP | HP:0001965 | Abnormal scalp morphology | Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows. | 8 | 1.833520e-02 | 1 |
| HP | HP:0005280 | Depressed nasal bridge | Posterior positioning of the nasal root in relation to the overall facial profile for age. | 9 | 1.969047e-02 | 1 |
| HP | HP:0007700 | Ocular anterior segment dysgenesis | Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin. | 7 | 2.431380e-02 | 1 |
| HP | HP:0001881 | Abnormal leukocyte morphology | An abnormality of leukocytes. | 9 | 2.496681e-02 | 1 |
| HP | HP:0010987 | Abnormal cellular immune system morphology | An abnormality of the morphology or counts of the cells that make up the immune system. | 9 | 2.496681e-02 | 1 |
| HP | HP:0000316 | Hypertelorism | Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes). | 10 | 2.597567e-02 | 1 |
| HP | HP:0032251 | Abnormal immune system morphology | Abnormal immune system morphology | 9 | 3.516642e-02 | 1 |
| HP | HP:0008678 | Renal hypoplasia/aplasia | Absence or underdevelopment of the kidney. | 7 | 4.318412e-02 | 1 |
| HP | HP:0034930 | Digestive system neoplasm | A tumor (abnormal growth of tissue) of the digestive system. | 7 | 4.478545e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 26 | 1.767354e-09 | 1 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 33 | 7.382378e-08 | 1 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 31 | 4.123129e-07 | 1 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 22 | 2.378572e-06 | 1 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 34 | 4.421280e-06 | 1 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 20 | 4.596968e-06 | 1 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 18 | 7.352883e-06 | 1 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 36 | 9.889075e-06 | 1 |
| HPA | HPA:0620000 | Vagina | Vagina | 36 | 9.889075e-06 | 1 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 38 | 3.237040e-05 | 1 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 38 | 3.237040e-05 | 1 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 33 | 3.669477e-05 | 1 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 33 | 6.412023e-05 | 1 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 30 | 8.043755e-05 | 1 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 19 | 8.543652e-05 | 1 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 37 | 9.054858e-05 | 1 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 37 | 9.054858e-05 | 1 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 35 | 9.801196e-05 | 1 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 32 | 9.805019e-05 | 1 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 17 | 1.394155e-04 | 1 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 36 | 1.684077e-04 | 1 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 32 | 1.712801e-04 | 1 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 27 | 1.765712e-04 | 1 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 29 | 2.369303e-04 | 1 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 33 | 3.248343e-04 | 1 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 19 | 3.373285e-04 | 1 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 31 | 5.358164e-04 | 1 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 28 | 8.189420e-04 | 1 |
| HPA | HPA:0400000 | Rectum | Rectum | 38 | 9.280699e-04 | 1 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 23 | 9.533292e-04 | 1 |
| HPA | HPA:0630000 | Cervix | Cervix | 36 | 1.174366e-03 | 1 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 28 | 1.226226e-03 | 1 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 36 | 1.279425e-03 | 1 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 15 | 1.285542e-03 | 1 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 37 | 1.476685e-03 | 1 |
| HPA | HPA:0380000 | Placenta | Placenta | 37 | 1.832940e-03 | 1 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 20 | 2.026441e-03 | 1 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 16 | 2.442737e-03 | 1 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 35 | 2.552869e-03 | 1 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 16 | 2.666572e-03 | 1 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 27 | 2.698755e-03 | 1 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 22 | 2.703334e-03 | 1 |
| HPA | HPA:0030053 | Appendix; glandular cells[High] | Appendix; glandular cells[High] | 18 | 3.100983e-03 | 1 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 31 | 3.332382e-03 | 1 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 15 | 3.523123e-03 | 1 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 30 | 3.862375e-03 | 1 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 28 | 3.925075e-03 | 1 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 31 | 4.631345e-03 | 1 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 13 | 5.033688e-03 | 1 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 35 | 5.526580e-03 | 1 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 35 | 5.728672e-03 | 1 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 35 | 5.728672e-03 | 1 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 37 | 6.434471e-03 | 1 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 20 | 7.429294e-03 | 1 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 33 | 8.252542e-03 | 1 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 29 | 8.834640e-03 | 1 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 37 | 9.523594e-03 | 1 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 33 | 9.726215e-03 | 1 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 36 | 1.051830e-02 | 1 |
| HPA | HPA:0080000 | Caudate | Caudate | 35 | 1.054848e-02 | 1 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 33 | 1.276757e-02 | 1 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 13 | 1.386713e-02 | 1 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 35 | 1.563232e-02 | 1 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 13 | 1.575181e-02 | 1 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 34 | 1.725982e-02 | 1 |
| HPA | HPA:0390000 | Prostate | Prostate | 34 | 1.725982e-02 | 1 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 26 | 1.751460e-02 | 1 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 34 | 1.755663e-02 | 1 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 34 | 1.755663e-02 | 1 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 32 | 1.888120e-02 | 1 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 28 | 1.942973e-02 | 1 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 34 | 2.002659e-02 | 1 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 34 | 2.133666e-02 | 1 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 33 | 2.183093e-02 | 1 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 33 | 2.267655e-02 | 1 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 18 | 2.522572e-02 | 1 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 31 | 2.625941e-02 | 1 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 32 | 2.970769e-02 | 1 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 36 | 3.088202e-02 | 1 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 36 | 3.088202e-02 | 1 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 26 | 3.100516e-02 | 1 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 36 | 3.140208e-02 | 1 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 36 | 3.140208e-02 | 1 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 31 | 3.256521e-02 | 1 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 29 | 3.357484e-02 | 1 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 28 | 3.996247e-02 | 1 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 20 | 4.195102e-02 | 1 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 12 | 4.683817e-02 | 1 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 24 | 4.696498e-02 | 1 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 34 | 4.732454e-02 | 1 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 35 | 4.994090e-02 | 1 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 35 | 4.994090e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 16 | 0.000459 | 1 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 14 | 0.003084 | 1 |
| MIRNA | MIRNA:hsa-mir-1180-3p | hsa-mir-1180-3p | hsa-mir-1180-3p | 4 | 0.012717 | 1 |
| MIRNA | MIRNA:hsa-mir-652-3p | hsa-mir-652-3p | hsa-mir-652-3p | 5 | 0.015747 | 1 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 11 | 0.018350 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M08298_1 | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1 | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1 | 22 | 0.020565 | 1 |
| TF | TF:M01770 | Factor: XBP-1; motif: WNNGMCACGTC | Factor: XBP-1; motif: WNNGMCACGTC | 39 | 0.026513 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0008540 | proteasome regulatory particle, base subcomplex | "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 4 | 6.417044e-09 | 2 |
| GO:CC | GO:0000502 | proteasome complex | "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome] | 5 | 5.552028e-08 | 2 |
| GO:CC | GO:0005838 | proteasome regulatory particle | "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 4 | 9.448753e-08 | 2 |
| GO:CC | GO:0022624 | proteasome accessory complex | "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] | 4 | 1.632224e-07 | 2 |
| GO:CC | GO:1905369 | endopeptidase complex | "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 5 | 4.501321e-07 | 2 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 14 | 4.751893e-07 | 2 |
| GO:CC | GO:1905368 | peptidase complex | "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 5 | 1.610730e-06 | 2 |
| GO:CC | GO:0034515 | proteasome storage granule | "An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:krc, GOC:rb, PMID:18504300, PMID:30204036] | 2 | 4.830828e-05 | 2 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 7 | 8.708500e-05 | 2 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 10 | 2.517847e-03 | 2 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 8 | 6.389884e-03 | 2 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 8 | 6.500650e-03 | 2 |
| GO:CC | GO:0099524 | postsynaptic cytosol | "The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos] | 2 | 1.322754e-02 | 2 |
| GO:CC | GO:0099522 | cytosolic region | "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos] | 2 | 3.006272e-02 | 2 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 14 | 4.448042e-02 | 2 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 10 | 4.450586e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5 | 0.000001 | 2 |
| REAC | REAC:R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5 | 0.000004 | 2 |
| REAC | REAC:R-HSA-1234174 | Cellular response to hypoxia | Cellular response to hypoxia | 5 | 0.000008 | 2 |
| REAC | REAC:R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | Regulation of mRNA stability by proteins that bind AU-rich elements | 5 | 0.000016 | 2 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 6 | 0.000046 | 2 |
| REAC | REAC:R-HSA-5610787 | Hedgehog 'off' state | Hedgehog 'off' state | 5 | 0.000062 | 2 |
| REAC | REAC:R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | Cross-presentation of soluble exogenous antigens (endosomes) | 4 | 0.000107 | 2 |
| REAC | REAC:R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4 | 0.000116 | 2 |
| REAC | REAC:R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | Regulation of ornithine decarboxylase (ODC) | 4 | 0.000126 | 2 |
| REAC | REAC:R-HSA-69610 | p53-Independent DNA Damage Response | p53-Independent DNA Damage Response | 4 | 0.000136 | 2 |
| REAC | REAC:R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 4 | 0.000136 | 2 |
| REAC | REAC:R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | Ubiquitin-dependent degradation of Cyclin D | 4 | 0.000136 | 2 |
| REAC | REAC:R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint | p53-Independent G1/S DNA damage checkpoint | 4 | 0.000136 | 2 |
| REAC | REAC:R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4 | 0.000136 | 2 |
| REAC | REAC:R-HSA-180534 | Vpu mediated degradation of CD4 | Vpu mediated degradation of CD4 | 4 | 0.000136 | 2 |
| REAC | REAC:R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | Autodegradation of the E3 ubiquitin ligase COP1 | 4 | 0.000136 | 2 |
| REAC | REAC:R-HSA-180585 | Vif-mediated degradation of APOBEC3G | Vif-mediated degradation of APOBEC3G | 4 | 0.000148 | 2 |
| REAC | REAC:R-HSA-169911 | Regulation of Apoptosis | Regulation of Apoptosis | 4 | 0.000148 | 2 |
| REAC | REAC:R-HSA-9604323 | Negative regulation of NOTCH4 signaling | Negative regulation of NOTCH4 signaling | 4 | 0.000148 | 2 |
| REAC | REAC:R-HSA-8941858 | Regulation of RUNX3 expression and activity | Regulation of RUNX3 expression and activity | 4 | 0.000172 | 2 |
| REAC | REAC:R-HSA-4641257 | Degradation of AXIN | Degradation of AXIN | 4 | 0.000172 | 2 |
| REAC | REAC:R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 4 | 0.000172 | 2 |
| REAC | REAC:R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | SCF-beta-TrCP mediated degradation of Emi1 | 4 | 0.000172 | 2 |
| REAC | REAC:R-HSA-9824272 | Somitogenesis | Somitogenesis | 4 | 0.000172 | 2 |
| REAC | REAC:R-HSA-5362768 | Hh mutants are degraded by ERAD | Hh mutants are degraded by ERAD | 4 | 0.000185 | 2 |
| REAC | REAC:R-HSA-69541 | Stabilization of p53 | Stabilization of p53 | 4 | 0.000198 | 2 |
| REAC | REAC:R-HSA-4641258 | Degradation of DVL | Degradation of DVL | 4 | 0.000198 | 2 |
| REAC | REAC:R-HSA-351202 | Metabolism of polyamines | Metabolism of polyamines | 4 | 0.000213 | 2 |
| REAC | REAC:R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | NIK-->noncanonical NF-kB signaling | 4 | 0.000228 | 2 |
| REAC | REAC:R-HSA-5387390 | Hh mutants abrogate ligand secretion | Hh mutants abrogate ligand secretion | 4 | 0.000228 | 2 |
| REAC | REAC:R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | GLI3 is processed to GLI3R by the proteasome | 4 | 0.000244 | 2 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 4 | 0.000244 | 2 |
| REAC | REAC:R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | Dectin-1 mediated noncanonical NF-kB signaling | 4 | 0.000244 | 2 |
| REAC | REAC:R-HSA-5610783 | Degradation of GLI2 by the proteasome | Degradation of GLI2 by the proteasome | 4 | 0.000244 | 2 |
| REAC | REAC:R-HSA-5610780 | Degradation of GLI1 by the proteasome | Degradation of GLI1 by the proteasome | 4 | 0.000244 | 2 |
| REAC | REAC:R-HSA-5358351 | Signaling by Hedgehog | Signaling by Hedgehog | 5 | 0.000246 | 2 |
| REAC | REAC:R-HSA-5678895 | Defective CFTR causes cystic fibrosis | Defective CFTR causes cystic fibrosis | 4 | 0.000261 | 2 |
| REAC | REAC:R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | Autodegradation of Cdh1 by Cdh1:APC/C | 4 | 0.000318 | 2 |
| REAC | REAC:R-HSA-4608870 | Asymmetric localization of PCP proteins | Asymmetric localization of PCP proteins | 4 | 0.000318 | 2 |
| REAC | REAC:R-HSA-5358346 | Hedgehog ligand biogenesis | Hedgehog ligand biogenesis | 4 | 0.000338 | 2 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 4 | 0.000360 | 2 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 4 | 0.000360 | 2 |
| REAC | REAC:R-HSA-5658442 | Regulation of RAS by GAPs | Regulation of RAS by GAPs | 4 | 0.000382 | 2 |
| REAC | REAC:R-HSA-1169091 | Activation of NF-kappaB in B cells | Activation of NF-kappaB in B cells | 4 | 0.000382 | 2 |
| REAC | REAC:R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | APC/C:Cdc20 mediated degradation of Securin | 4 | 0.000406 | 2 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 4 | 0.000406 | 2 |
| REAC | REAC:R-HSA-8948751 | Regulation of PTEN stability and activity | Regulation of PTEN stability and activity | 4 | 0.000430 | 2 |
| REAC | REAC:R-HSA-9793380 | Formation of paraxial mesoderm | Formation of paraxial mesoderm | 4 | 0.000430 | 2 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 4 | 0.000483 | 2 |
| REAC | REAC:R-HSA-8939902 | Regulation of RUNX2 expression and activity | Regulation of RUNX2 expression and activity | 4 | 0.000483 | 2 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 5 | 0.000487 | 2 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 4 | 0.000540 | 2 |
| REAC | REAC:R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4 | 0.000540 | 2 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 7 | 0.000553 | 2 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 4 | 0.000571 | 2 |
| REAC | REAC:R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 4 | 0.000571 | 2 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 4 | 0.000636 | 2 |
| REAC | REAC:R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4 | 0.000670 | 2 |
| REAC | REAC:R-HSA-5619084 | ABC transporter disorders | ABC transporter disorders | 4 | 0.000706 | 2 |
| REAC | REAC:R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | The role of GTSE1 in G2/M progression after G2 checkpoint | 4 | 0.000743 | 2 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 7 | 0.000749 | 2 |
| REAC | REAC:R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | Downstream signaling events of B Cell Receptor (BCR) | 4 | 0.000781 | 2 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 4 | 0.000821 | 2 |
| REAC | REAC:R-HSA-9013694 | Signaling by NOTCH4 | Signaling by NOTCH4 | 4 | 0.000821 | 2 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 4 | 0.000863 | 2 |
| REAC | REAC:R-HSA-195253 | Degradation of beta-catenin by the destruction complex | Degradation of beta-catenin by the destruction complex | 4 | 0.000906 | 2 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 4 | 0.000950 | 2 |
| REAC | REAC:R-HSA-5632684 | Hedgehog 'on' state | Hedgehog 'on' state | 4 | 0.000997 | 2 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 4 | 0.001145 | 2 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 4 | 0.001145 | 2 |
| REAC | REAC:R-HSA-5687128 | MAPK6/MAPK4 signaling | MAPK6/MAPK4 signaling | 4 | 0.001198 | 2 |
| REAC | REAC:R-HSA-1236974 | ER-Phagosome pathway | ER-Phagosome pathway | 4 | 0.001253 | 2 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 4 | 0.001368 | 2 |
| REAC | REAC:R-HSA-4086400 | PCP/CE pathway | PCP/CE pathway | 4 | 0.001368 | 2 |
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 4 | 0.001555 | 2 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 4 | 0.001555 | 2 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 4 | 0.001690 | 2 |
| REAC | REAC:R-HSA-202424 | Downstream TCR signaling | Downstream TCR signaling | 4 | 0.001761 | 2 |
| REAC | REAC:R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | TNFR2 non-canonical NF-kB pathway | 4 | 0.001909 | 2 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 5 | 0.001916 | 2 |
| REAC | REAC:R-HSA-5689603 | UCH proteinases | UCH proteinases | 4 | 0.002066 | 2 |
| REAC | REAC:R-HSA-382556 | ABC-family proteins mediated transport | ABC-family proteins mediated transport | 4 | 0.002148 | 2 |
| REAC | REAC:R-HSA-1236975 | Antigen processing-Cross presentation | Antigen processing-Cross presentation | 4 | 0.002319 | 2 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 6 | 0.003028 | 2 |
| REAC | REAC:R-HSA-9020702 | Interleukin-1 signaling | Interleukin-1 signaling | 4 | 0.003105 | 2 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 4 | 0.003687 | 2 |
| REAC | REAC:R-HSA-202403 | TCR signaling | TCR signaling | 4 | 0.003941 | 2 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 4 | 0.004073 | 2 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 4 | 0.004487 | 2 |
| REAC | REAC:R-HSA-9758941 | Gastrulation | Gastrulation | 4 | 0.004632 | 2 |
| REAC | REAC:R-HSA-162909 | Host Interactions of HIV factors | Host Interactions of HIV factors | 4 | 0.004933 | 2 |
| REAC | REAC:R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4 | 0.005247 | 2 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 4 | 0.005576 | 2 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 4 | 0.006465 | 2 |
| REAC | REAC:R-HSA-2871837 | FCERI mediated NF-kB activation | FCERI mediated NF-kB activation | 4 | 0.006465 | 2 |
| REAC | REAC:R-HSA-9006925 | Intracellular signaling by second messengers | Intracellular signaling by second messengers | 5 | 0.006659 | 2 |
| REAC | REAC:R-HSA-6807070 | PTEN Regulation | PTEN Regulation | 4 | 0.006848 | 2 |
| REAC | REAC:R-HSA-68867 | Assembly of the pre-replicative complex | Assembly of the pre-replicative complex | 4 | 0.007664 | 2 |
| REAC | REAC:R-HSA-3858494 | Beta-catenin independent WNT signaling | Beta-catenin independent WNT signaling | 4 | 0.007879 | 2 |
| REAC | REAC:R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | Antigen processing: Ubiquitination & Proteasome degradation | 5 | 0.008614 | 2 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 4 | 0.009020 | 2 |
| REAC | REAC:R-HSA-446652 | Interleukin-1 family signaling | Interleukin-1 family signaling | 4 | 0.009760 | 2 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 4 | 0.011953 | 2 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 4 | 0.012862 | 2 |
| REAC | REAC:R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | Signaling by the B Cell Receptor (BCR) | 4 | 0.013176 | 2 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 4 | 0.014488 | 2 |
| REAC | REAC:R-HSA-5619115 | Disorders of transmembrane transporters | Disorders of transmembrane transporters | 4 | 0.016633 | 2 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 4 | 0.017788 | 2 |
| REAC | REAC:R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | Fc epsilon receptor (FCERI) signaling | 4 | 0.020274 | 2 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 4 | 0.022533 | 2 |
| REAC | REAC:R-HSA-2467813 | Separation of Sister Chromatids | Separation of Sister Chromatids | 4 | 0.023006 | 2 |
| REAC | REAC:R-HSA-983169 | Class I MHC mediated antigen processing & presentation | Class I MHC mediated antigen processing & presentation | 5 | 0.023567 | 2 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 4 | 0.027056 | 2 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 4 | 0.028145 | 2 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 9 | 0.028930 | 2 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 4 | 0.034075 | 2 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 4 | 0.035363 | 2 |
| REAC | REAC:R-HSA-5689880 | Ub-specific processing proteases | Ub-specific processing proteases | 4 | 0.043088 | 2 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 7 | 0.045446 | 2 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 4 | 0.048603 | 2 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 4 | 0.049430 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:32 | PA700 complex | PA700 complex | 4 | 0.000020 | 2 |
| CORUM | CORUM:193 | PA700-20S-PA28 complex | PA700-20S-PA28 complex | 4 | 0.000163 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 9 | 0.000032 | 2 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 9 | 0.000052 | 2 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 10 | 0.000153 | 2 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 10 | 0.000243 | 2 |
| GO:MF | GO:0120544 | polypeptide conformation or assembly isomerase activity | "Catalysis of a reaction that alters the conformation or assembly of a polypeptide." [EC:5.6.1.-] | 4 | 0.000283 | 2 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 8 | 0.000472 | 2 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 9 | 0.000496 | 2 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 9 | 0.000530 | 2 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 9 | 0.000713 | 2 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 9 | 0.001298 | 2 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 9 | 0.001382 | 2 |
| GO:MF | GO:0036402 | proteasome-activating activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome." [GOC:rb, PMID:11430818] | 2 | 0.001622 | 2 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 9 | 0.002020 | 2 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 8 | 0.005204 | 2 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 4 | 0.008989 | 2 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 5 | 0.010769 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03050 | Proteasome | Proteasome | 4 | 0.000042 | 2 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 5 | 0.002623 | 2 |
| KEGG | KEGG:05020 | Prion disease | Prion disease | 5 | 0.002920 | 2 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | Spinocerebellar ataxia | 4 | 0.003708 | 2 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 5 | 0.005135 | 2 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 5 | 0.011695 | 2 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 4 | 0.013827 | 2 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 5 | 0.014855 | 2 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 5 | 0.040380 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP183 | Proteasome degradation | Proteasome degradation | 4 | 0.000146 | 2 |
| WP | WP:WP2359 | Parkin ubiquitin proteasomal system pathway | Parkin ubiquitin proteasomal system pathway | 4 | 0.000253 | 2 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 5 | 0.002003 | 2 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 5 | 0.002197 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 5 | 0.006573 | 2 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 8 | 0.008792 | 2 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 11 | 0.017433 | 2 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 5 | 0.024490 | 2 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 6 | 0.040480 | 2 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 5 | 0.049257 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 11 | 0.011809 | 2 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 7 | 0.041241 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 7 | 0.000776 | 3 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 4 | 0.004427 | 3 |
| GO:CC | GO:0005912 | adherens junction | "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] | 3 | 0.006077 | 3 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 6 | 0.012445 | 3 |
| GO:CC | GO:0014704 | intercalated disc | "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910] | 2 | 0.024581 | 3 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 4 | 0.033505 | 3 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 4 | 0.037441 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0071896 | protein localization to adherens junction | "Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237] | 2 | 0.003547 | 3 |
| GO:BP | GO:0043297 | apical junction assembly | "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556] | 3 | 0.006469 | 3 |
| GO:BP | GO:0060429 | epithelium development | "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] | 6 | 0.008188 | 3 |
| GO:BP | GO:0030855 | epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] | 5 | 0.014014 | 3 |
| GO:BP | GO:0002065 | columnar/cuboidal epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] | 3 | 0.021627 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008013 | beta-catenin binding | "Binding to a catenin beta subunit." [GOC:bf] | 3 | 0.004703 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 3 | 0.010003 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 5 | 0.049823 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-320d | hsa-mir-320d | hsa-mir-320d | 5 | 0.023263 | 4 |
| MIRNA | MIRNA:hsa-mir-4429 | hsa-mir-4429 | hsa-mir-4429 | 5 | 0.023350 | 4 |
| MIRNA | MIRNA:hsa-mir-320c | hsa-mir-320c | hsa-mir-320c | 5 | 0.024962 | 4 |
| MIRNA | MIRNA:hsa-mir-320b | hsa-mir-320b | hsa-mir-320b | 5 | 0.028247 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 4 | 0.024480 | 4 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 4 | 0.032308 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3965 | Lipid metabolism pathway | Lipid metabolism pathway | 2 | 0.026109 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004312 | fatty acid synthase activity | "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] | 1 | 0.049963 | 4 |
| GO:MF | GO:0004313 | [acyl-carrier-protein] S-acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [RHEA:41788] | 1 | 0.049963 | 4 |
| GO:MF | GO:0031177 | phosphopantetheine binding | "Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [GOC:mah, GOC:vw] | 1 | 0.049963 | 4 |
| GO:MF | GO:0140778 | microtubule stabilizing activity | "A protein-containing complex stabilizing activity that prevents dissociation of microtubules." [PMID:34970964] | 1 | 0.049963 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006364 | rRNA processing | "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] | 5 | 0.000038 | 5 |
| GO:BP | GO:0016072 | rRNA metabolic process | "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] | 5 | 0.000087 | 5 |
| GO:BP | GO:0042254 | ribosome biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] | 5 | 0.000228 | 5 |
| GO:BP | GO:0022613 | ribonucleoprotein complex biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] | 7 | 0.004422 | 5 |
| GO:BP | GO:0042273 | ribosomal large subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 3 | 0.004849 | 5 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 10 | 0.011963 | 5 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 10 | 0.014111 | 5 |
| GO:BP | GO:0006396 | RNA processing | "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] | 8 | 0.014920 | 5 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 10 | 0.016124 | 5 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 10 | 0.021576 | 5 |
| GO:BP | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] | 2 | 0.028307 | 5 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 10 | 0.035356 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 9 | 0.000070 | 5 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 9 | 0.009836 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005730 | nucleolus | "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] | 7 | 0.000475 | 5 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 10 | 0.041974 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2363 | Gastric cancer network 2 | Gastric cancer network 2 | 2 | 0.002373 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3055 | Nop56p-associated pre-rRNA complex | Nop56p-associated pre-rRNA complex | 3 | 0.003315 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 5 | 0.01719 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 7 | 1.540332e-07 | 6 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 7 | 2.197282e-06 | 6 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 7 | 4.462676e-06 | 6 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 7 | 2.883021e-04 | 6 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 5 | 4.098934e-04 | 6 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 4 | 2.245393e-03 | 6 |
| GO:BP | GO:0006338 | chromatin remodeling | "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] | 5 | 2.572343e-03 | 6 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 4 | 3.613706e-03 | 6 |
| GO:BP | GO:0006325 | chromatin organization | "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] | 5 | 6.815797e-03 | 6 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 5 | 7.123550e-03 | 6 |
| GO:BP | GO:0000727 | double-strand break repair via break-induced replication | "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] | 2 | 8.692439e-03 | 6 |
| GO:BP | GO:0006275 | regulation of DNA replication | "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] | 3 | 1.035716e-02 | 6 |
| GO:BP | GO:0030174 | regulation of DNA-templated DNA replication initiation | "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah] | 2 | 1.382099e-02 | 6 |
| GO:BP | GO:0044027 | negative regulation of gene expression via chromosomal CpG island methylation | "An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes." [PMID:11898023, Wikipedia:Cpg_island] | 2 | 1.382099e-02 | 6 |
| GO:BP | GO:1902969 | mitotic DNA replication | "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] | 2 | 1.789466e-02 | 6 |
| GO:BP | GO:0045945 | positive regulation of transcription by RNA polymerase III | "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators, GOC:txnOH] | 2 | 2.249134e-02 | 6 |
| GO:BP | GO:0000724 | double-strand break repair via homologous recombination | "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] | 3 | 3.970579e-02 | 6 |
| GO:BP | GO:0000725 | recombinational repair | "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] | 3 | 4.293822e-02 | 6 |
| GO:BP | GO:0045814 | negative regulation of gene expression, epigenetic | "An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696] | 3 | 4.774802e-02 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 8 | 6.051591e-07 | 6 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 8 | 2.548675e-04 | 6 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 3 | 2.849455e-04 | 6 |
| GO:CC | GO:0000792 | heterochromatin | "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] | 3 | 3.871983e-04 | 6 |
| GO:CC | GO:0110016 | B-WICH complex | "A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself." [GOC:bhm, PMID:16603771, PMID:21559432, PMID:23555303, PMID:26044184] | 2 | 4.410097e-04 | 6 |
| GO:CC | GO:0071162 | CMG complex | "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417] | 2 | 8.657998e-04 | 6 |
| GO:CC | GO:0042555 | MCM complex | "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] | 2 | 8.657998e-04 | 6 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 4 | 9.950702e-04 | 6 |
| GO:CC | GO:0031261 | DNA replication preinitiation complex | "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184] | 2 | 1.227418e-03 | 6 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 8 | 2.107947e-03 | 6 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 5 | 6.687455e-03 | 6 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 3 | 8.769483e-03 | 6 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 8 | 9.303346e-03 | 6 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 8 | 9.314518e-03 | 6 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 8 | 9.597656e-03 | 6 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 8 | 9.597656e-03 | 6 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 8 | 9.597656e-03 | 6 |
| GO:CC | GO:0043596 | nuclear replication fork | "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] | 2 | 1.283851e-02 | 6 |
| GO:CC | GO:0000791 | euchromatin | "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] | 2 | 3.143302e-02 | 6 |
| GO:CC | GO:0034693 | U11/U12 snRNP | "A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins." [GOC:mah, PMID:15146077] | 1 | 4.988814e-02 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5352 | 10q11 21q11 23 copy number variation syndrome | 10q11 21q11 23 copy number variation syndrome | 3 | 0.001246 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 3 | 0.001563 | 6 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 3 | 0.001642 | 6 |
| GO:MF | GO:0004386 | helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] | 3 | 0.003457 | 6 |
| GO:MF | GO:0120545 | nucleic acid conformation isomerase activity | "Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-] | 3 | 0.004148 | 6 |
| GO:MF | GO:0017116 | single-stranded DNA helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl] | 2 | 0.004602 | 6 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 6 | 0.011627 | 6 |
| GO:MF | GO:0042393 | histone binding | "Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837] | 3 | 0.012080 | 6 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 3 | 0.014944 | 6 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 3 | 0.020646 | 6 |
| GO:MF | GO:0003678 | DNA helicase activity | "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl] | 2 | 0.030902 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6194 | B-WICH complex | B-WICH complex | 2 | 0.002053 | 6 |
| CORUM | CORUM:6302 | B-WICH complex | B-WICH complex | 2 | 0.002637 | 6 |
| CORUM | CORUM:929 | CEN complex | CEN complex | 2 | 0.040288 | 6 |
| CORUM | CORUM:2791 | MCM4-MCM6-MCM7 complex | MCM4-MCM6-MCM7 complex | 1 | 0.049819 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-176974 | Unwinding of DNA | Unwinding of DNA | 2 | 0.007604 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03030 | DNA replication | DNA replication | 2 | 0.012736 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11537_1 | Factor: E2F-8; motif: NNTTCCCGCCAAAW; match class: 1 | Factor: E2F-8; motif: NNTTCCCGCCAAAW; match class: 1 | 2 | 0.021283 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 8 | 2.205630e-10 | 7 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 8 | 8.783822e-10 | 7 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 8 | 4.233798e-08 | 7 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 8 | 3.313255e-06 | 7 |
| GO:CC | GO:0034451 | centriolar satellite | "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812] | 4 | 1.042735e-05 | 7 |
| GO:CC | GO:0005814 | centriole | "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] | 4 | 2.606020e-05 | 7 |
| GO:CC | GO:0036064 | ciliary basal body | "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193] | 4 | 3.471224e-05 | 7 |
| GO:CC | GO:0005929 | cilium | "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] | 5 | 4.006448e-04 | 7 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 6 | 5.654973e-03 | 7 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 8 | 9.303346e-03 | 7 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 8 | 9.314518e-03 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 6 | 0.000028 | 7 |
| GO:BP | GO:0060271 | cilium assembly | "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441] | 5 | 0.000140 | 7 |
| GO:BP | GO:0044782 | cilium organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] | 5 | 0.000196 | 7 |
| GO:BP | GO:0071539 | protein localization to centrosome | "A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd] | 3 | 0.000291 | 7 |
| GO:BP | GO:0007017 | microtubule-based process | "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] | 6 | 0.000305 | 7 |
| GO:BP | GO:1905508 | protein localization to microtubule organizing center | "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497] | 3 | 0.000316 | 7 |
| GO:BP | GO:0070925 | organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 6 | 0.000400 | 7 |
| GO:BP | GO:0120031 | plasma membrane bounded cell projection assembly | "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 5 | 0.001011 | 7 |
| GO:BP | GO:0030031 | cell projection assembly | "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:18391171] | 5 | 0.001124 | 7 |
| GO:BP | GO:0072698 | protein localization to microtubule cytoskeleton | "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah] | 3 | 0.001151 | 7 |
| GO:BP | GO:0044380 | protein localization to cytoskeleton | "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl] | 3 | 0.001409 | 7 |
| GO:BP | GO:1905515 | non-motile cilium assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834] | 3 | 0.001866 | 7 |
| GO:BP | GO:0035735 | intraciliary transport involved in cilium assembly | "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia] | 2 | 0.002768 | 7 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 6 | 0.003760 | 7 |
| GO:BP | GO:0007098 | centrosome cycle | "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] | 3 | 0.016447 | 7 |
| GO:BP | GO:0031023 | microtubule organizing center organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] | 3 | 0.021457 | 7 |
| GO:BP | GO:0034453 | microtubule anchoring | "Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah] | 2 | 0.042690 | 7 |
| GO:BP | GO:0021846 | cell proliferation in forebrain | "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.046096 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5502 | 16p13 11 copy number variation syndrome | 16p13 11 copy number variation syndrome | 3 | 0.000031 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | Loss of proteins required for interphase microtubule organization from the centrosome | 3 | 0.000041 | 7 |
| REAC | REAC:R-HSA-380259 | Loss of Nlp from mitotic centrosomes | Loss of Nlp from mitotic centrosomes | 3 | 0.000041 | 7 |
| REAC | REAC:R-HSA-8854518 | AURKA Activation by TPX2 | AURKA Activation by TPX2 | 3 | 0.000047 | 7 |
| REAC | REAC:R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | Recruitment of mitotic centrosome proteins and complexes | 3 | 0.000068 | 7 |
| REAC | REAC:R-HSA-380287 | Centrosome maturation | Centrosome maturation | 3 | 0.000068 | 7 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 3 | 0.000081 | 7 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 3 | 0.000111 | 7 |
| REAC | REAC:R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | Anchoring of the basal body to the plasma membrane | 3 | 0.000118 | 7 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 3 | 0.001019 | 7 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 3 | 0.001051 | 7 |
| REAC | REAC:R-HSA-68877 | Mitotic Prometaphase | Mitotic Prometaphase | 3 | 0.001083 | 7 |
| REAC | REAC:R-HSA-5617833 | Cilium Assembly | Cilium Assembly | 3 | 0.001083 | 7 |
| REAC | REAC:R-HSA-1852241 | Organelle biogenesis and maintenance | Organelle biogenesis and maintenance | 3 | 0.003353 | 7 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 3 | 0.009201 | 7 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 3 | 0.022626 | 7 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 3 | 0.042851 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-7 | hsa-mir-7 | hsa-mir-7 | 6 | 0.001616 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7235 | DISC1-DRD2 complex | DISC1-DRD2 complex | 1 | 0.049988 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005884 | actin filament | "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] | 6 | 5.915560e-10 | 8 |
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 7 | 5.677720e-08 | 8 |
| GO:CC | GO:0030863 | cortical cytoskeleton | "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] | 5 | 1.075310e-07 | 8 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 6 | 2.226941e-07 | 8 |
| GO:CC | GO:0030426 | growth cone | "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] | 5 | 6.393842e-07 | 8 |
| GO:CC | GO:0030427 | site of polarized growth | "Any part of a cell where non-isotropic growth takes place." [GOC:mah] | 5 | 7.409615e-07 | 8 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 7 | 2.335946e-06 | 8 |
| GO:CC | GO:0150034 | distal axon | "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] | 5 | 8.394418e-06 | 8 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 6 | 5.245727e-05 | 8 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 5 | 6.619508e-05 | 8 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 5 | 7.423635e-05 | 8 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 8 | 7.676363e-05 | 8 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 8 | 9.695026e-05 | 8 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 6 | 2.436182e-04 | 8 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 6 | 2.544731e-04 | 8 |
| GO:CC | GO:0030424 | axon | "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] | 5 | 5.655128e-04 | 8 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 10 | 6.742922e-04 | 8 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 10 | 6.753047e-04 | 8 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 7 | 7.246139e-04 | 8 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 7 | 7.968671e-04 | 8 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 7 | 7.993766e-04 | 8 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 7 | 7.993766e-04 | 8 |
| GO:CC | GO:0043005 | neuron projection | "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] | 6 | 9.728236e-04 | 8 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 7 | 1.378822e-03 | 8 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 6 | 1.428016e-03 | 8 |
| GO:CC | GO:0005903 | brush border | "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] | 3 | 1.542492e-03 | 8 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 7 | 1.921534e-03 | 8 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 8 | 4.206099e-03 | 8 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 9 | 5.378564e-03 | 8 |
| GO:CC | GO:0098862 | cluster of actin-based cell projections | "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] | 3 | 5.868831e-03 | 8 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 4 | 6.519565e-03 | 8 |
| GO:CC | GO:0001726 | ruffle | "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] | 3 | 7.172631e-03 | 8 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 9 | 1.065653e-02 | 8 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 7 | 1.460541e-02 | 8 |
| GO:CC | GO:0002102 | podosome | "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] | 2 | 1.648617e-02 | 8 |
| GO:CC | GO:0009925 | basal plasma membrane | "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] | 3 | 2.810858e-02 | 8 |
| GO:CC | GO:0016459 | myosin complex | "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin] | 2 | 3.309789e-02 | 8 |
| GO:CC | GO:0045178 | basal part of cell | "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] | 3 | 3.382809e-02 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 8 | 3.347701e-07 | 8 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 8 | 5.346171e-06 | 8 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 6 | 1.243389e-05 | 8 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 7 | 2.621978e-05 | 8 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 6 | 1.237617e-04 | 8 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 7 | 1.648728e-04 | 8 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 7 | 2.415110e-04 | 8 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 7 | 2.548748e-04 | 8 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 7 | 4.389956e-04 | 8 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 5 | 5.490058e-04 | 8 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 7 | 6.569412e-04 | 8 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 6 | 7.704653e-04 | 8 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 6 | 1.145245e-03 | 8 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 6 | 1.309975e-03 | 8 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 5 | 1.778467e-03 | 8 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 6 | 2.046665e-03 | 8 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 6 | 2.639195e-03 | 8 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 6 | 2.837907e-03 | 8 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 6 | 4.660073e-03 | 8 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 6 | 5.106043e-03 | 8 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 5 | 9.598001e-03 | 8 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 5 | 1.076516e-02 | 8 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 5 | 1.562798e-02 | 8 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 5 | 1.707518e-02 | 8 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 5 | 1.835894e-02 | 8 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 5 | 2.664116e-02 | 8 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 5 | 2.808011e-02 | 8 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 5 | 3.531580e-02 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 8 | 3.725575e-07 | 8 |
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 6 | 2.437767e-05 | 8 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 6 | 3.689423e-04 | 8 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 6 | 7.644602e-04 | 8 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 7 | 1.217613e-03 | 8 |
| GO:BP | GO:0030050 | vesicle transport along actin filament | "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] | 2 | 1.063120e-02 | 8 |
| GO:BP | GO:0099515 | actin filament-based transport | "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb] | 2 | 1.558452e-02 | 8 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 8 | 2.727657e-02 | 8 |
| GO:BP | GO:0030048 | actin filament-based movement | "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] | 3 | 3.572775e-02 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 6 | 7.036339e-07 | 8 |
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 6 | 3.684439e-06 | 8 |
| GO:MF | GO:0051015 | actin filament binding | "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 5 | 4.874194e-06 | 8 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 7 | 1.344205e-05 | 8 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 6 | 1.568802e-05 | 8 |
| GO:MF | GO:0005516 | calmodulin binding | "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] | 4 | 3.908930e-04 | 8 |
| GO:MF | GO:0005522 | profilin binding | "Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544] | 2 | 1.779806e-03 | 8 |
| GO:MF | GO:0044548 | S100 protein binding | "Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] | 2 | 3.595373e-03 | 8 |
| GO:MF | GO:1901981 | phosphatidylinositol phosphate binding | "Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487] | 3 | 1.453555e-02 | 8 |
| GO:MF | GO:0000146 | microfilament motor activity | "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949] | 2 | 2.615439e-02 | 8 |
| GO:MF | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | "Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl] | 2 | 3.060706e-02 | 8 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 5 | 3.946180e-02 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5627123 | RHO GTPases activate PAKs | RHO GTPases activate PAKs | 3 | 0.000083 | 8 |
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 6 | 0.000410 | 8 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 6 | 0.000465 | 8 |
| REAC | REAC:R-HSA-195258 | RHO GTPase Effectors | RHO GTPase Effectors | 4 | 0.010926 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 4 | 0.000531 | 8 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 3 | 0.019557 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12100_1 | Factor: ZNF524; motif: NCTCGNACCCNN; match class: 1 | Factor: ZNF524; motif: NCTCGNACCCNN; match class: 1 | 3 | 0.002245 | 8 |
| TF | TF:M00800_1 | Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 | Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 | 9 | 0.012688 | 8 |
| TF | TF:M09973_1 | Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 | Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 | 10 | 0.029771 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1-3p | hsa-mir-1-3p | hsa-mir-1-3p | 5 | 0.037149 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP524 | G13 signaling | G13 signaling | 2 | 0.045054 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1844 | APC-IQGAP1 complex | APC-IQGAP1 complex | 1 | 0.04968 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | Formation of tubulin folding intermediates by CCT/TriC | 4 | 1.965074e-07 | 9 |
| REAC | REAC:R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4 | 5.370428e-07 | 9 |
| REAC | REAC:R-HSA-390450 | Folding of actin by CCT/TriC | Folding of actin by CCT/TriC | 3 | 4.350590e-06 | 9 |
| REAC | REAC:R-HSA-390466 | Chaperonin-mediated protein folding | Chaperonin-mediated protein folding | 4 | 3.463387e-05 | 9 |
| REAC | REAC:R-HSA-391251 | Protein folding | Protein folding | 4 | 4.484014e-05 | 9 |
| REAC | REAC:R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | Prefoldin mediated transfer of substrate to CCT/TriC | 3 | 1.181890e-04 | 9 |
| REAC | REAC:R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | Association of TriC/CCT with target proteins during biosynthesis | 3 | 3.035171e-04 | 9 |
| REAC | REAC:R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3 | 3.035171e-04 | 9 |
| REAC | REAC:R-HSA-9013418 | RHOBTB2 GTPase cycle | RHOBTB2 GTPase cycle | 2 | 2.009342e-02 | 9 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 3 | 4.257518e-02 | 9 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 3 | 4.387450e-02 | 9 |
| REAC | REAC:R-HSA-68877 | Mitotic Prometaphase | Mitotic Prometaphase | 3 | 4.519949e-02 | 9 |
| REAC | REAC:R-HSA-5617833 | Cilium Assembly | Cilium Assembly | 3 | 4.519949e-02 | 9 |
| REAC | REAC:R-HSA-9706574 | RHOBTB GTPase Cycle | RHOBTB GTPase Cycle | 2 | 4.708363e-02 | 9 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005832 | chaperonin-containing T-complex | "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] | 3 | 5.119924e-07 | 9 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 7 | 4.951766e-06 | 9 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 5 | 3.879349e-05 | 9 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 3 | 4.524372e-05 | 9 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 7 | 2.147062e-04 | 9 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 5 | 4.901061e-04 | 9 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 5 | 1.768198e-03 | 9 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 5 | 1.833829e-03 | 9 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 6 | 2.430376e-03 | 9 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 6 | 2.638704e-03 | 9 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 6 | 2.645893e-03 | 9 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 6 | 2.645893e-03 | 9 |
| GO:CC | GO:0000159 | protein phosphatase type 2A complex | "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430] | 2 | 2.687963e-03 | 9 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 7 | 6.139947e-03 | 9 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 5 | 7.764095e-03 | 9 |
| GO:CC | GO:0008287 | protein serine/threonine phosphatase complex | "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf] | 2 | 2.404608e-02 | 9 |
| GO:CC | GO:1903293 | phosphatase complex | "A protein complex which is capable of phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807] | 2 | 2.404608e-02 | 9 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 6 | 3.293521e-02 | 9 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051086 | chaperone mediated protein folding independent of cofactor | "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] | 3 | 0.000002 | 9 |
| GO:BP | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 3 | 0.000003 | 9 |
| GO:BP | GO:1904871 | positive regulation of protein localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 3 | 0.000005 | 9 |
| GO:BP | GO:1904869 | regulation of protein localization to Cajal body | "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 3 | 0.000005 | 9 |
| GO:BP | GO:1903405 | protein localization to nuclear body | "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] | 3 | 0.000008 | 9 |
| GO:BP | GO:1904872 | regulation of telomerase RNA localization to Cajal body | "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 3 | 0.000008 | 9 |
| GO:BP | GO:1904867 | protein localization to Cajal body | "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 3 | 0.000008 | 9 |
| GO:BP | GO:1990173 | protein localization to nucleoplasm | "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] | 3 | 0.000014 | 9 |
| GO:BP | GO:0090671 | telomerase RNA localization to Cajal body | "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 3 | 0.000036 | 9 |
| GO:BP | GO:0090670 | RNA localization to Cajal body | "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 3 | 0.000036 | 9 |
| GO:BP | GO:0090685 | RNA localization to nucleus | "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] | 3 | 0.000036 | 9 |
| GO:BP | GO:0090672 | telomerase RNA localization | "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 3 | 0.000036 | 9 |
| GO:BP | GO:0032212 | positive regulation of telomere maintenance via telomerase | "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 3 | 0.000076 | 9 |
| GO:BP | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 3 | 0.000110 | 9 |
| GO:BP | GO:0051084 | 'de novo' post-translational protein folding | "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] | 3 | 0.000461 | 9 |
| GO:BP | GO:0032210 | regulation of telomere maintenance via telomerase | "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 3 | 0.000567 | 9 |
| GO:BP | GO:0006458 | 'de novo' protein folding | "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] | 3 | 0.000646 | 9 |
| GO:BP | GO:2000573 | positive regulation of DNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 3 | 0.000778 | 9 |
| GO:BP | GO:1904356 | regulation of telomere maintenance via telomere lengthening | "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 3 | 0.000979 | 9 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 3 | 0.001276 | 9 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 3 | 0.001480 | 9 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 3 | 0.002313 | 9 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 3 | 0.002410 | 9 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 3 | 0.002510 | 9 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 3 | 0.004655 | 9 |
| GO:BP | GO:1900182 | positive regulation of protein localization to nucleus | "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 3 | 0.005128 | 9 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 3 | 0.006932 | 9 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 5 | 0.007124 | 9 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 3 | 0.008418 | 9 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 3 | 0.018651 | 9 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 5 | 0.020286 | 9 |
| GO:BP | GO:0008037 | cell recognition | "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators] | 3 | 0.024074 | 9 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 3 | 0.026409 | 9 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 3 | 0.030448 | 9 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 4 | 0.036726 | 9 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 3 | 0.041625 | 9 |
| GO:BP | GO:0006403 | RNA localization | "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] | 3 | 0.047748 | 9 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:126 | CCT complex (chaperonin containing TCP1 complex) | CCT complex (chaperonin containing TCP1 complex) | 3 | 0.000003 | 9 |
| CORUM | CORUM:1543 | PPP2CA-PPP2R1A complex | PPP2CA-PPP2R1A complex | 1 | 0.049932 | 9 |
| CORUM | CORUM:2711 | Amyloid beta protein homo-oligomer complex | Amyloid beta protein homo-oligomer complex | 1 | 0.049932 | 9 |
| CORUM | CORUM:7529 | APP-Abeta42-VDAC1 complex | APP-Abeta42-VDAC1 complex | 1 | 0.049932 | 9 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 3 | 0.000024 | 9 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 3 | 0.000268 | 9 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 7 | 0.000458 | 9 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 3 | 0.001242 | 9 |
| GO:MF | GO:0016787 | hydrolase activity | "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] | 7 | 0.002539 | 9 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 6 | 0.003711 | 9 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 6 | 0.004376 | 9 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 6 | 0.004581 | 9 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 6 | 0.005611 | 9 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 6 | 0.008465 | 9 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 6 | 0.008838 | 9 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 6 | 0.012056 | 9 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 8 | 0.012912 | 9 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 6 | 0.015934 | 9 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 8 | 0.016533 | 9 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4949 | 16p11 2 proximal deletion syndrome | 16p11 2 proximal deletion syndrome | 4 | 0.000047 | 9 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 8 | 0.041153 | 9 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | COPI-independent Golgi-to-ER retrograde traffic | 8 | 4.166324e-17 | 10 |
| REAC | REAC:R-HSA-8856688 | Golgi-to-ER retrograde transport | Golgi-to-ER retrograde transport | 8 | 9.209899e-14 | 10 |
| REAC | REAC:R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | Intra-Golgi and retrograde Golgi-to-ER traffic | 8 | 2.808622e-12 | 10 |
| REAC | REAC:R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | 6 | 1.023354e-10 | 10 |
| REAC | REAC:R-HSA-6807878 | COPI-mediated anterograde transport | COPI-mediated anterograde transport | 6 | 3.770668e-09 | 10 |
| REAC | REAC:R-HSA-2132295 | MHC class II antigen presentation | MHC class II antigen presentation | 6 | 1.186017e-08 | 10 |
| REAC | REAC:R-HSA-199991 | Membrane Trafficking | Membrane Trafficking | 8 | 2.595052e-08 | 10 |
| REAC | REAC:R-HSA-199977 | ER to Golgi Anterograde Transport | ER to Golgi Anterograde Transport | 6 | 4.849507e-08 | 10 |
| REAC | REAC:R-HSA-5653656 | Vesicle-mediated transport | Vesicle-mediated transport | 8 | 8.007556e-08 | 10 |
| REAC | REAC:R-HSA-948021 | Transport to the Golgi and subsequent modification | Transport to the Golgi and subsequent modification | 6 | 1.464941e-07 | 10 |
| REAC | REAC:R-HSA-446203 | Asparagine N-linked glycosylation | Asparagine N-linked glycosylation | 6 | 2.885503e-06 | 10 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 6 | 8.679666e-04 | 10 |
| REAC | REAC:R-HSA-1280218 | Adaptive Immune System | Adaptive Immune System | 6 | 9.617623e-04 | 10 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 6 | 9.617623e-04 | 10 |
| REAC | REAC:R-HSA-68877 | Mitotic Prometaphase | Mitotic Prometaphase | 4 | 1.750516e-03 | 10 |
| REAC | REAC:R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | Loss of proteins required for interphase microtubule organization from the centrosome | 3 | 3.090883e-03 | 10 |
| REAC | REAC:R-HSA-380259 | Loss of Nlp from mitotic centrosomes | Loss of Nlp from mitotic centrosomes | 3 | 3.090883e-03 | 10 |
| REAC | REAC:R-HSA-8854518 | AURKA Activation by TPX2 | AURKA Activation by TPX2 | 3 | 3.521395e-03 | 10 |
| REAC | REAC:R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | Recruitment of mitotic centrosome proteins and complexes | 3 | 5.046422e-03 | 10 |
| REAC | REAC:R-HSA-380287 | Centrosome maturation | Centrosome maturation | 3 | 5.046422e-03 | 10 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 3 | 6.056266e-03 | 10 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 3 | 8.193867e-03 | 10 |
| REAC | REAC:R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | Anchoring of the basal body to the plasma membrane | 3 | 8.728015e-03 | 10 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 4 | 2.867126e-02 | 10 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 6 | 2.872490e-02 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0072393 | microtubule anchoring at microtubule organizing center | "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938] | 4 | 1.718083e-08 | 10 |
| GO:BP | GO:0007017 | microtubule-based process | "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] | 8 | 2.422433e-07 | 10 |
| GO:BP | GO:0034453 | microtubule anchoring | "Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah] | 4 | 2.560112e-07 | 10 |
| GO:BP | GO:0010970 | transport along microtubule | "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] | 4 | 6.725889e-04 | 10 |
| GO:BP | GO:0051656 | establishment of organelle localization | "The directed movement of an organelle to a specific location." [GOC:ai] | 5 | 8.816930e-04 | 10 |
| GO:BP | GO:0072385 | minus-end-directed organelle transport along microtubule | "The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah] | 2 | 1.085315e-03 | 10 |
| GO:BP | GO:0030705 | cytoskeleton-dependent intracellular transport | "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] | 4 | 1.277249e-03 | 10 |
| GO:BP | GO:0099111 | microtubule-based transport | "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] | 4 | 1.567098e-03 | 10 |
| GO:BP | GO:0051640 | organelle localization | "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] | 5 | 2.783903e-03 | 10 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 5 | 4.074458e-03 | 10 |
| GO:BP | GO:0072384 | organelle transport along microtubule | "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] | 3 | 6.947798e-03 | 10 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 6 | 1.128667e-02 | 10 |
| GO:BP | GO:0034454 | microtubule anchoring at centrosome | "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah] | 2 | 1.191728e-02 | 10 |
| GO:BP | GO:0010457 | centriole-centriole cohesion | "The cell cycle process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb] | 2 | 1.894668e-02 | 10 |
| GO:BP | GO:0007018 | microtubule-based movement | "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] | 4 | 3.372898e-02 | 10 |
| GO:BP | GO:0032402 | melanosome transport | "The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ln] | 2 | 4.161798e-02 | 10 |
| GO:BP | GO:0070507 | regulation of microtubule cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 3 | 4.201249e-02 | 10 |
| GO:BP | GO:0051904 | pigment granule transport | "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 2 | 4.557147e-02 | 10 |
| GO:BP | GO:0032401 | establishment of melanosome localization | "The directed movement of a melanosome to a specific location." [GOC:mah] | 2 | 4.557147e-02 | 10 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 4 | 4.585566e-02 | 10 |
| GO:BP | GO:0051905 | establishment of pigment granule localization | "The directed movement of a pigment granule to a specific location." [GOC:ai] | 2 | 4.970330e-02 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6960 | BICD2-dynein-dynactin complex | BICD2-dynein-dynactin complex | 3 | 2.606835e-08 | 10 |
| CORUM | CORUM:6039 | Dynein-dynactin complex | Dynein-dynactin complex | 2 | 4.401642e-04 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04814 | Motor proteins | Motor proteins | 6 | 1.932671e-07 | 10 |
| KEGG | KEGG:04962 | Vasopressin-regulated water reabsorption | Vasopressin-regulated water reabsorption | 4 | 2.424022e-06 | 10 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 5 | 6.090981e-05 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 7 | 1.994269e-07 | 10 |
| GO:CC | GO:0005875 | microtubule associated complex | "Any multimeric complex connected to a microtubule." [GOC:jl] | 5 | 2.706991e-07 | 10 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 8 | 3.194822e-07 | 10 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 9 | 3.282199e-07 | 10 |
| GO:CC | GO:0030286 | dynein complex | "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] | 4 | 4.839104e-07 | 10 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 7 | 6.601288e-07 | 10 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 6 | 1.136552e-06 | 10 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 7 | 1.980529e-05 | 10 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 6 | 2.406144e-05 | 10 |
| GO:CC | GO:0000776 | kinetochore | "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] | 4 | 5.397278e-05 | 10 |
| GO:CC | GO:0000779 | condensed chromosome, centromeric region | "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] | 4 | 7.058637e-05 | 10 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 6 | 1.128487e-04 | 10 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 6 | 1.179148e-04 | 10 |
| GO:CC | GO:0000775 | chromosome, centromeric region | "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] | 4 | 2.870250e-04 | 10 |
| GO:CC | GO:0000793 | condensed chromosome | "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] | 4 | 3.949186e-04 | 10 |
| GO:CC | GO:0005869 | dynactin complex | "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732] | 2 | 5.042296e-04 | 10 |
| GO:CC | GO:0120103 | centriolar subdistal appendage | "A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68." [GOC:cilia, PMID:23213374, PMID:27818179, PMID:28422092] | 2 | 8.100275e-04 | 10 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 4 | 1.570123e-03 | 10 |
| GO:CC | GO:0005819 | spindle | "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] | 4 | 2.158276e-03 | 10 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 9 | 2.489405e-03 | 10 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 9 | 2.492769e-03 | 10 |
| GO:CC | GO:0005868 | cytoplasmic dynein complex | "Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311] | 2 | 4.541694e-03 | 10 |
| GO:CC | GO:0000922 | spindle pole | "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] | 3 | 5.254659e-03 | 10 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 8 | 1.301703e-02 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5085 | Vasopressin regulated water reabsorption | Vasopressin regulated water reabsorption | 4 | 9.092633e-07 | 10 |
| WP | WP:WP5376 | 17p13 3 YWHAE copy number variation | 17p13 3 YWHAE copy number variation | 3 | 2.604993e-05 | 10 |
| WP | WP:WP5443 | Effects of MFN2 mutation | Effects of MFN2 mutation | 2 | 1.180077e-02 | 10 |
| WP | WP:WP4532 | Intraflagellar transport proteins binding to dynein | Intraflagellar transport proteins binding to dynein | 2 | 1.499376e-02 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 7 | 0.000004 | 10 |
| GO:MF | GO:0045503 | dynein light chain binding | "Binding to a light chain of the dynein complex." [GOC:bf] | 2 | 0.001063 | 10 |
| GO:MF | GO:0034452 | dynactin binding | "Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah] | 2 | 0.001947 | 10 |
| GO:MF | GO:0045504 | dynein heavy chain binding | "Binding to a heavy chain of the dynein complex." [GOC:bf] | 2 | 0.003537 | 10 |
| GO:MF | GO:0008093 | cytoskeletal anchor activity | "The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238] | 2 | 0.008121 | 10 |
| GO:MF | GO:0070840 | dynein complex binding | "Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah] | 2 | 0.008825 | 10 |
| GO:MF | GO:0030507 | spectrin binding | "Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732] | 2 | 0.009558 | 10 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 5 | 0.019443 | 10 |
| GO:MF | GO:0008017 | microtubule binding | "Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc] | 3 | 0.035162 | 10 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 4 | 0.042940 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0042393 | histone binding | "Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837] | 3 | 0.01208 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006469 | negative regulation of protein kinase activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] | 3 | 0.015753 | 11 |
| GO:BP | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] | 2 | 0.017895 | 11 |
| GO:BP | GO:0033673 | negative regulation of kinase activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] | 3 | 0.018271 | 11 |
| GO:BP | GO:1904030 | negative regulation of cyclin-dependent protein kinase activity | "Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] | 2 | 0.022491 | 11 |
| GO:BP | GO:0051348 | negative regulation of transferase activity | "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] | 3 | 0.027879 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-214-3p | hsa-mir-214-3p | hsa-mir-214-3p | 3 | 0.032078 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2366 | Butyrate induced histone acetylation | Butyrate induced histone acetylation | 1 | 0.044744 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 6 | 1.844472e-08 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 5 | 2.526021e-08 | 12 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 5 | 2.526021e-08 | 12 |
| GO:CC | GO:0140534 | endoplasmic reticulum protein-containing complex | "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] | 5 | 2.759172e-08 | 12 |
| GO:CC | GO:0005788 | endoplasmic reticulum lumen | "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] | 6 | 2.867717e-08 | 12 |
| GO:CC | GO:1902687 | glucosidase complex | "A protein complex which is capable of glucosidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932] | 2 | 1.576743e-05 | 12 |
| GO:CC | GO:0017177 | glucosidase II complex | "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335] | 2 | 1.576743e-05 | 12 |
| GO:CC | GO:0005783 | endoplasmic reticulum | "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] | 7 | 6.804790e-05 | 12 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 8 | 7.535959e-04 | 12 |
| GO:CC | GO:0034663 | endoplasmic reticulum chaperone complex | "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] | 2 | 8.657998e-04 | 12 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 6 | 7.383124e-03 | 12 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 6 | 7.483978e-03 | 12 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 4 | 2.417480e-02 | 12 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 6 | 3.293521e-02 | 12 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 5 | 4.730967e-02 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016864 | intramolecular oxidoreductase activity, transposing S-S bonds | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4.-, GOC:mah] | 3 | 0.000005 | 12 |
| GO:MF | GO:0003756 | protein disulfide isomerase activity | "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function] | 3 | 0.000005 | 12 |
| GO:MF | GO:0015035 | protein-disulfide reductase activity | "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385] | 3 | 0.000032 | 12 |
| GO:MF | GO:0015036 | disulfide oxidoreductase activity | "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [GOC:curators] | 3 | 0.000053 | 12 |
| GO:MF | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.8.-.-, GOC:ai] | 3 | 0.000141 | 12 |
| GO:MF | GO:0016860 | intramolecular oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators] | 3 | 0.000149 | 12 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 6 | 0.035696 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0034975 | protein folding in endoplasmic reticulum | "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw] | 3 | 0.000008 | 12 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 4 | 0.000808 | 12 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 4 | 0.001862 | 12 |
| GO:BP | GO:0006491 | N-glycan processing | "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198] | 2 | 0.022491 | 12 |
| GO:BP | GO:0098761 | cellular response to interleukin-7 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] | 2 | 0.024986 | 12 |
| GO:BP | GO:0098760 | response to interleukin-7 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] | 2 | 0.027610 | 12 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 4 | 0.028691 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-901042 | Calnexin/calreticulin cycle | Calnexin/calreticulin cycle | 3 | 0.000053 | 12 |
| REAC | REAC:R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3 | 0.000132 | 12 |
| REAC | REAC:R-HSA-9683686 | Maturation of spike protein | Maturation of spike protein | 2 | 0.000558 | 12 |
| REAC | REAC:R-HSA-8957275 | Post-translational protein phosphorylation | Post-translational protein phosphorylation | 3 | 0.003942 | 12 |
| REAC | REAC:R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 3 | 0.006138 | 12 |
| REAC | REAC:R-HSA-9683701 | Translation of Structural Proteins | Translation of Structural Proteins | 2 | 0.022509 | 12 |
| REAC | REAC:R-HSA-9694548 | Maturation of spike protein | Maturation of spike protein | 2 | 0.036852 | 12 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 5 | 0.047682 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00687 | Factor: alpha-CP1; motif: CAGCCAATGAG | Factor: alpha-CP1; motif: CAGCCAATGAG | 7 | 0.003082 | 12 |
| TF | TF:M12616 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS | 7 | 0.012016 | 12 |
| TF | TF:M04683 | Factor: NF-YA; motif: YTCTSATTGGYYRN | Factor: NF-YA; motif: YTCTSATTGGYYRN | 6 | 0.012458 | 12 |
| TF | TF:M12616_1 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS; match class: 1 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS; match class: 1 | 4 | 0.049700 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 6 | 0.017099 | 12 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 6 | 0.048771 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0006557 | Polycystic liver disease | Polycystic liver disease | 2 | 0.022 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3995 | Prion disease pathway | Prion disease pathway | 2 | 0.022513 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:472 | Prolyl 4-hydroxylase (alpha(I)-type) | Prolyl 4-hydroxylase (alpha(I)-type) | 1 | 0.049932 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000932 | P-body | "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603] | 4 | 0.000004 | 13 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 4 | 0.000168 | 13 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 4 | 0.000222 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc] | 4 | 0.000005 | 13 |
| GO:BP | GO:0061157 | mRNA destabilization | "Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh] | 4 | 0.000037 | 13 |
| GO:BP | GO:0050779 | RNA destabilization | "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai] | 4 | 0.000044 | 13 |
| GO:BP | GO:0061014 | positive regulation of mRNA catabolic process | "Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 4 | 0.000046 | 13 |
| GO:BP | GO:0000956 | nuclear-transcribed mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] | 4 | 0.000091 | 13 |
| GO:BP | GO:1903313 | positive regulation of mRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 4 | 0.000151 | 13 |
| GO:BP | GO:0043488 | regulation of mRNA stability | "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] | 4 | 0.000377 | 13 |
| GO:BP | GO:0043487 | regulation of RNA stability | "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] | 4 | 0.000488 | 13 |
| GO:BP | GO:0061013 | regulation of mRNA catabolic process | "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 4 | 0.000540 | 13 |
| GO:BP | GO:0006402 | mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 4 | 0.001627 | 13 |
| GO:BP | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA | "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544] | 2 | 0.001978 | 13 |
| GO:BP | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay | "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544] | 2 | 0.002768 | 13 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 4 | 0.003309 | 13 |
| GO:BP | GO:0006401 | RNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 4 | 0.003437 | 13 |
| GO:BP | GO:0141188 | nucleic acid catabolic process | "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators] | 4 | 0.004819 | 13 |
| GO:BP | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA | "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc] | 2 | 0.007245 | 13 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 7 | 0.007724 | 13 |
| GO:BP | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | "Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] | 2 | 0.010271 | 13 |
| GO:BP | GO:0060211 | regulation of nuclear-transcribed mRNA poly(A) tail shortening | "Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] | 2 | 0.013821 | 13 |
| GO:BP | GO:0110156 | mRNA methylguanosine-cap decapping | "Cleavage of the 5'-methylguanosine-cap of an mRNA. The methylguanosine-cap is present at the 5'-end of eukaryotic mRNAs. Decapping inactivates translation initiation and promotes 5'-to-3' decay of mRNA." [PMID:23287066] | 2 | 0.015792 | 13 |
| GO:BP | GO:0035278 | miRNA-mediated gene silencing by inhibition of translation | "An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs." [PMID:14744438, PMID:15196554] | 2 | 0.020128 | 13 |
| GO:BP | GO:0110154 | RNA decapping | "Cleavage of the 5'-cap of an RNA." [GOC:sp, PMID:25533955, PMID:31101919] | 2 | 0.022491 | 13 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 4 | 0.027864 | 13 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 4 | 0.030182 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4783-3p | hsa-mir-4783-3p | hsa-mir-4783-3p | 4 | 0.000092 | 13 |
| MIRNA | MIRNA:hsa-mir-4285 | hsa-mir-4285 | hsa-mir-4285 | 3 | 0.000434 | 13 |
| MIRNA | MIRNA:hsa-mir-3179 | hsa-mir-3179 | hsa-mir-3179 | 6 | 0.000697 | 13 |
| MIRNA | MIRNA:hsa-mir-3065-5p | hsa-mir-3065-5p | hsa-mir-3065-5p | 6 | 0.001598 | 13 |
| MIRNA | MIRNA:hsa-mir-1909 | hsa-mir-1909 | hsa-mir-1909 | 6 | 0.001815 | 13 |
| MIRNA | MIRNA:hsa-mir-2467-3p | hsa-mir-2467-3p | hsa-mir-2467-3p | 6 | 0.006181 | 13 |
| MIRNA | MIRNA:hsa-mir-570 | hsa-mir-570 | hsa-mir-570 | 6 | 0.006316 | 13 |
| MIRNA | MIRNA:hsa-mir-3156-3p | hsa-mir-3156-3p | hsa-mir-3156-3p | 5 | 0.007690 | 13 |
| MIRNA | MIRNA:hsa-mir-106b-5p | hsa-mir-106b-5p | hsa-mir-106b-5p | 5 | 0.007726 | 13 |
| MIRNA | MIRNA:hsa-mir-4283 | hsa-mir-4283 | hsa-mir-4283 | 5 | 0.007726 | 13 |
| MIRNA | MIRNA:hsa-mir-1976 | hsa-mir-1976 | hsa-mir-1976 | 6 | 0.007993 | 13 |
| MIRNA | MIRNA:hsa-mir-3188 | hsa-mir-3188 | hsa-mir-3188 | 5 | 0.008173 | 13 |
| MIRNA | MIRNA:hsa-mir-3977 | hsa-mir-3977 | hsa-mir-3977 | 5 | 0.008483 | 13 |
| MIRNA | MIRNA:hsa-mir-519a | hsa-mir-519a | hsa-mir-519a | 5 | 0.012323 | 13 |
| MIRNA | MIRNA:hsa-mir-3925-5p | hsa-mir-3925-5p | hsa-mir-3925-5p | 5 | 0.014045 | 13 |
| MIRNA | MIRNA:hsa-mir-3680 | hsa-mir-3680 | hsa-mir-3680 | 4 | 0.021011 | 13 |
| MIRNA | MIRNA:hsa-mir-627 | hsa-mir-627 | hsa-mir-627 | 4 | 0.023361 | 13 |
| MIRNA | MIRNA:hsa-mir-1322 | hsa-mir-1322 | hsa-mir-1322 | 4 | 0.023668 | 13 |
| MIRNA | MIRNA:hsa-mir-4449 | hsa-mir-4449 | hsa-mir-4449 | 3 | 0.025129 | 13 |
| MIRNA | MIRNA:hsa-mir-4472 | hsa-mir-4472 | hsa-mir-4472 | 5 | 0.028348 | 13 |
| MIRNA | MIRNA:hsa-mir-4447 | hsa-mir-4447 | hsa-mir-4447 | 5 | 0.028348 | 13 |
| MIRNA | MIRNA:hsa-mir-625 | hsa-mir-625 | hsa-mir-625 | 5 | 0.031199 | 13 |
| MIRNA | MIRNA:hsa-mir-299-5p | hsa-mir-299-5p | hsa-mir-299-5p | 4 | 0.033731 | 13 |
| MIRNA | MIRNA:hsa-mir-1253 | hsa-mir-1253 | hsa-mir-1253 | 5 | 0.038086 | 13 |
| MIRNA | MIRNA:hsa-mir-185 | hsa-mir-185 | hsa-mir-185 | 5 | 0.038086 | 13 |
| MIRNA | MIRNA:hsa-mir-4723-5p | hsa-mir-4723-5p | hsa-mir-4723-5p | 5 | 0.039782 | 13 |
| MIRNA | MIRNA:hsa-mir-4801 | hsa-mir-4801 | hsa-mir-4801 | 5 | 0.040450 | 13 |
| MIRNA | MIRNA:hsa-mir-4731-3p | hsa-mir-4731-3p | hsa-mir-4731-3p | 5 | 0.040585 | 13 |
| MIRNA | MIRNA:hsa-mir-3978 | hsa-mir-3978 | hsa-mir-3978 | 5 | 0.042089 | 13 |
| MIRNA | MIRNA:hsa-mir-525-5p | hsa-mir-525-5p | hsa-mir-525-5p | 5 | 0.044067 | 13 |
| MIRNA | MIRNA:hsa-mir-520a-5p | hsa-mir-520a-5p | hsa-mir-520a-5p | 5 | 0.044211 | 13 |
| MIRNA | MIRNA:hsa-mir-4306 | hsa-mir-4306 | hsa-mir-4306 | 5 | 0.045229 | 13 |
| MIRNA | MIRNA:hsa-mir-4644 | hsa-mir-4644 | hsa-mir-4644 | 5 | 0.045671 | 13 |
| MIRNA | MIRNA:hsa-mir-548ah | hsa-mir-548ah | hsa-mir-548ah | 5 | 0.048550 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140933 | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity | "Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+." [PMID:18820299, PMID:29483298] | 2 | 0.000183 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-426496 | Post-transcriptional silencing by small RNAs | Post-transcriptional silencing by small RNAs | 2 | 0.001676 | 13 |
| REAC | REAC:R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2 | 0.002234 | 13 |
| REAC | REAC:R-HSA-8943723 | Regulation of PTEN mRNA translation | Regulation of PTEN mRNA translation | 2 | 0.002871 | 13 |
| REAC | REAC:R-HSA-9768778 | Regulation of NPAS4 mRNA translation | Regulation of NPAS4 mRNA translation | 2 | 0.002871 | 13 |
| REAC | REAC:R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | Regulation of CDH11 mRNA translation by microRNAs | 2 | 0.002871 | 13 |
| REAC | REAC:R-HSA-9768759 | Regulation of NPAS4 gene expression | Regulation of NPAS4 gene expression | 2 | 0.006214 | 13 |
| REAC | REAC:R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | mRNA decay by 5' to 3' exoribonuclease | 2 | 0.008359 | 13 |
| REAC | REAC:R-HSA-446728 | Cell junction organization | Cell junction organization | 3 | 0.008473 | 13 |
| REAC | REAC:R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | Regulation of MITF-M-dependent genes involved in apoptosis | 2 | 0.010821 | 13 |
| REAC | REAC:R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | Regulation of RUNX1 Expression and Activity | 2 | 0.010821 | 13 |
| REAC | REAC:R-HSA-3858494 | Beta-catenin independent WNT signaling | Beta-catenin independent WNT signaling | 3 | 0.016682 | 13 |
| REAC | REAC:R-HSA-1500931 | Cell-Cell communication | Cell-Cell communication | 3 | 0.019235 | 13 |
| REAC | REAC:R-HSA-9759475 | Regulation of CDH11 Expression and Function | Regulation of CDH11 Expression and Function | 2 | 0.027843 | 13 |
| REAC | REAC:R-HSA-9022692 | Regulation of MECP2 expression and activity | Regulation of MECP2 expression and activity | 2 | 0.032186 | 13 |
| REAC | REAC:R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | Regulation of Homotypic Cell-Cell Adhesion | 2 | 0.034475 | 13 |
| REAC | REAC:R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | Regulation of Expression and Function of Type II Classical Cadherins | 2 | 0.034475 | 13 |
| REAC | REAC:R-HSA-9634815 | Transcriptional Regulation by NPAS4 | Transcriptional Regulation by NPAS4 | 2 | 0.041807 | 13 |
| REAC | REAC:R-HSA-2559585 | Oncogene Induced Senescence | Oncogene Induced Senescence | 2 | 0.041807 | 13 |
| REAC | REAC:R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | 2 | 0.049838 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03018 | RNA degradation | RNA degradation | 2 | 0.027257 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 7 | 2.045844e-08 | 14 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 6 | 1.896735e-06 | 14 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 7 | 1.893601e-05 | 14 |
| GO:MF | GO:0016740 | transferase activity | "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-] | 7 | 8.132813e-05 | 14 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 7 | 1.568965e-04 | 14 |
| GO:MF | GO:0034450 | ubiquitin-ubiquitin ligase activity | "Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603] | 2 | 1.551478e-03 | 14 |
| GO:MF | GO:0031435 | mitogen-activated protein kinase kinase kinase binding | "Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase." [GOC:bf] | 2 | 2.008872e-03 | 14 |
| GO:MF | GO:0004709 | MAP kinase kinase kinase activity | "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] | 2 | 4.793501e-03 | 14 |
| GO:MF | GO:0005164 | tumor necrosis factor receptor binding | "Binding to a tumor necrosis factor receptor." [GOC:ai] | 2 | 7.308393e-03 | 14 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 4 | 1.038138e-02 | 14 |
| GO:MF | GO:0051879 | Hsp90 protein binding | "Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai] | 2 | 1.391146e-02 | 14 |
| GO:MF | GO:0032813 | tumor necrosis factor receptor superfamily binding | "Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add] | 2 | 1.799651e-02 | 14 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 4 | 1.807778e-02 | 14 |
| GO:MF | GO:0061630 | ubiquitin protein ligase activity | "Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777] | 3 | 2.652276e-02 | 14 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 4 | 2.653940e-02 | 14 |
| GO:MF | GO:0106310 | protein serine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989] | 3 | 2.674163e-02 | 14 |
| GO:MF | GO:0061659 | ubiquitin-like protein ligase activity | "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] | 3 | 3.112748e-02 | 14 |
| GO:MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] | 4 | 4.971410e-02 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043507 | positive regulation of JUN kinase activity | "Any process that activates or increases the frequency, rate or extent of JUN kinase activity." [GOC:jl] | 4 | 7.525109e-08 | 14 |
| GO:BP | GO:0043506 | regulation of JUN kinase activity | "Any process that modulates the frequency, rate or extent of JUN kinase activity." [GOC:jl] | 4 | 3.521935e-07 | 14 |
| GO:BP | GO:0071900 | regulation of protein serine/threonine kinase activity | "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] | 5 | 3.994503e-06 | 14 |
| GO:BP | GO:0043406 | positive regulation of MAP kinase activity | "Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] | 4 | 4.145279e-06 | 14 |
| GO:BP | GO:0000165 | MAPK cascade | "An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267] | 6 | 1.306946e-05 | 14 |
| GO:BP | GO:0043405 | regulation of MAP kinase activity | "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] | 4 | 2.934608e-05 | 14 |
| GO:BP | GO:0045859 | regulation of protein kinase activity | "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] | 5 | 5.071694e-05 | 14 |
| GO:BP | GO:0038095 | Fc-epsilon receptor signaling pathway | "The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:12413516, PMID:15048725] | 3 | 5.180542e-05 | 14 |
| GO:BP | GO:0071902 | positive regulation of protein serine/threonine kinase activity | "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] | 4 | 5.773435e-05 | 14 |
| GO:BP | GO:0043549 | regulation of kinase activity | "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] | 5 | 7.180037e-05 | 14 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 6 | 1.019588e-04 | 14 |
| GO:BP | GO:0051338 | regulation of transferase activity | "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] | 5 | 1.475377e-04 | 14 |
| GO:BP | GO:0006468 | protein phosphorylation | "The process of introducing a phosphate group on to a protein." [GOC:hb] | 6 | 2.596797e-04 | 14 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 6 | 4.012847e-04 | 14 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 5 | 5.017350e-04 | 14 |
| GO:BP | GO:0045860 | positive regulation of protein kinase activity | "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] | 4 | 5.547539e-04 | 14 |
| GO:BP | GO:0038093 | Fc receptor signaling pathway | "The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, Wikipedia:Fc_receptor] | 3 | 6.917345e-04 | 14 |
| GO:BP | GO:0033674 | positive regulation of kinase activity | "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] | 4 | 7.075279e-04 | 14 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 7 | 8.271313e-04 | 14 |
| GO:BP | GO:0070534 | protein K63-linked ubiquitination | "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404] | 3 | 1.172731e-03 | 14 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 7 | 1.282991e-03 | 14 |
| GO:BP | GO:0051347 | positive regulation of transferase activity | "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] | 4 | 1.302991e-03 | 14 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] | 5 | 1.360464e-03 | 14 |
| GO:BP | GO:0051865 | protein autoubiquitination | "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai] | 3 | 1.571946e-03 | 14 |
| GO:BP | GO:0042325 | regulation of phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] | 5 | 1.861754e-03 | 14 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 6 | 3.029501e-03 | 14 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 5 | 3.230979e-03 | 14 |
| GO:BP | GO:0050776 | regulation of immune response | "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 5 | 3.570753e-03 | 14 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 6 | 3.624489e-03 | 14 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 5 | 3.741287e-03 | 14 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 5 | 3.760627e-03 | 14 |
| GO:BP | GO:0097400 | interleukin-17-mediated signaling pathway | "The series of molecular signals initiated by interleukin-17 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ic, PMID:21602493] | 2 | 5.217945e-03 | 14 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 5 | 5.638997e-03 | 14 |
| GO:BP | GO:0043410 | positive regulation of MAPK cascade | "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators] | 4 | 7.256137e-03 | 14 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 7 | 8.870479e-03 | 14 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] | 4 | 9.111604e-03 | 14 |
| GO:BP | GO:0046328 | regulation of JNK cascade | "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] | 3 | 9.916865e-03 | 14 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] | 4 | 1.095203e-02 | 14 |
| GO:BP | GO:0023035 | CD40 signaling pathway | "The series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mtg_signal, GOC:signaling, PMID:11348017] | 2 | 1.137558e-02 | 14 |
| GO:BP | GO:0097398 | cellular response to interleukin-17 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr] | 2 | 1.289028e-02 | 14 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 6 | 1.413408e-02 | 14 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 6 | 1.423828e-02 | 14 |
| GO:BP | GO:0097396 | response to interleukin-17 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr] | 2 | 1.449927e-02 | 14 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] | 4 | 1.566590e-02 | 14 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 4 | 1.634615e-02 | 14 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 4 | 1.634615e-02 | 14 |
| GO:BP | GO:0007254 | JNK cascade | "A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation." [PMID:11790549, PMID:20811974, PMID:23125017] | 3 | 1.935562e-02 | 14 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators] | 4 | 2.715735e-02 | 14 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 7 | 2.867098e-02 | 14 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 5 | 3.011444e-02 | 14 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 5 | 3.369166e-02 | 14 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 5 | 3.480513e-02 | 14 |
| GO:BP | GO:0002726 | positive regulation of T cell cytokine production | "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] | 2 | 3.576495e-02 | 14 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 6 | 3.582721e-02 | 14 |
| GO:BP | GO:0034612 | response to tumor necrosis factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] | 3 | 4.321196e-02 | 14 |
| GO:BP | GO:0002682 | regulation of immune system process | "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] | 5 | 4.411334e-02 | 14 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 6 | 4.819192e-02 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP382 | MAPK signaling | MAPK signaling | 5 | 0.000039 | 14 |
| WP | WP:WP231 | TNF alpha signaling | TNF alpha signaling | 4 | 0.000040 | 14 |
| WP | WP:WP5530 | MAPK signaling and ARTD family members | MAPK signaling and ARTD family members | 3 | 0.000182 | 14 |
| WP | WP:WP4877 | Host pathogen interaction of human coronaviruses MAPK signaling | Host pathogen interaction of human coronaviruses MAPK signaling | 3 | 0.000262 | 14 |
| WP | WP:WP3941 | Oxidative damage response | Oxidative damage response | 3 | 0.000362 | 14 |
| WP | WP:WP2637 | Interleukin 1 IL 1 structural pathway | Interleukin 1 IL 1 structural pathway | 3 | 0.000673 | 14 |
| WP | WP:WP2018 | RANKL RANK signaling | RANKL RANK signaling | 3 | 0.000716 | 14 |
| WP | WP:WP3611 | Photodynamic therapy induced AP 1 survival signaling | Photodynamic therapy induced AP 1 survival signaling | 3 | 0.000716 | 14 |
| WP | WP:WP195 | IL1 signaling | IL1 signaling | 3 | 0.000905 | 14 |
| WP | WP:WP3865 | Novel intracellular components of RIG I like receptor pathway | Novel intracellular components of RIG I like receptor pathway | 3 | 0.001246 | 14 |
| WP | WP:WP3849 | MAPK and NFkB signaling inhibited by Yersinia YopJ | MAPK and NFkB signaling inhibited by Yersinia YopJ | 2 | 0.004272 | 14 |
| WP | WP:WP3915 | Angiopoietin like protein 8 regulatory pathway | Angiopoietin like protein 8 regulatory pathway | 3 | 0.013306 | 14 |
| WP | WP:WP4666 | Hepatitis B infection | Hepatitis B infection | 3 | 0.020238 | 14 |
| WP | WP:WP5087 | Pleural mesothelioma | Pleural mesothelioma | 4 | 0.022143 | 14 |
| WP | WP:WP481 | Insulin signaling | Insulin signaling | 3 | 0.023562 | 14 |
| WP | WP:WP422 | MAPK cascade | MAPK cascade | 2 | 0.033903 | 14 |
| WP | WP:WP4496 | Signal transduction through IL1R | Signal transduction through IL1R | 2 | 0.033903 | 14 |
| WP | WP:WP400 | p38 MAPK signaling | p38 MAPK signaling | 2 | 0.036009 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | Toll Like Receptor 10 (TLR10) Cascade | 4 | 0.000041 | 14 |
| REAC | REAC:R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | Toll Like Receptor 5 (TLR5) Cascade | 4 | 0.000041 | 14 |
| REAC | REAC:R-HSA-975871 | MyD88 cascade initiated on plasma membrane | MyD88 cascade initiated on plasma membrane | 4 | 0.000041 | 14 |
| REAC | REAC:R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4 | 0.000051 | 14 |
| REAC | REAC:R-HSA-975155 | MyD88 dependent cascade initiated on endosome | MyD88 dependent cascade initiated on endosome | 4 | 0.000053 | 14 |
| REAC | REAC:R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4 | 0.000055 | 14 |
| REAC | REAC:R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | Toll Like Receptor 9 (TLR9) Cascade | 4 | 0.000062 | 14 |
| REAC | REAC:R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | Toll Like Receptor TLR6:TLR2 Cascade | 4 | 0.000077 | 14 |
| REAC | REAC:R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4 | 0.000077 | 14 |
| REAC | REAC:R-HSA-933542 | TRAF6 mediated NF-kB activation | TRAF6 mediated NF-kB activation | 3 | 0.000083 | 14 |
| REAC | REAC:R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | Toll Like Receptor TLR1:TLR2 Cascade | 4 | 0.000086 | 14 |
| REAC | REAC:R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | Toll Like Receptor 2 (TLR2) Cascade | 4 | 0.000086 | 14 |
| REAC | REAC:R-HSA-5675482 | Regulation of necroptotic cell death | Regulation of necroptotic cell death | 3 | 0.000162 | 14 |
| REAC | REAC:R-HSA-5213460 | RIPK1-mediated regulated necrosis | RIPK1-mediated regulated necrosis | 3 | 0.000162 | 14 |
| REAC | REAC:R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | Toll Like Receptor 4 (TLR4) Cascade | 4 | 0.000214 | 14 |
| REAC | REAC:R-HSA-168898 | Toll-like Receptor Cascades | Toll-like Receptor Cascades | 4 | 0.000380 | 14 |
| REAC | REAC:R-HSA-5218859 | Regulated Necrosis | Regulated Necrosis | 3 | 0.001104 | 14 |
| REAC | REAC:R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3 | 0.003148 | 14 |
| REAC | REAC:R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | Toll Like Receptor 3 (TLR3) Cascade | 3 | 0.006251 | 14 |
| REAC | REAC:R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | TRIF (TICAM1)-mediated TLR4 signaling | 3 | 0.007008 | 14 |
| REAC | REAC:R-HSA-166166 | MyD88-independent TLR4 cascade | MyD88-independent TLR4 cascade | 3 | 0.007008 | 14 |
| REAC | REAC:R-HSA-9758274 | Regulation of NF-kappa B signaling | Regulation of NF-kappa B signaling | 2 | 0.012170 | 14 |
| REAC | REAC:R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | 2 | 0.018352 | 14 |
| REAC | REAC:R-HSA-73887 | Death Receptor Signaling | Death Receptor Signaling | 3 | 0.020404 | 14 |
| REAC | REAC:R-HSA-8863795 | Downregulation of ERBB2 signaling | Downregulation of ERBB2 signaling | 2 | 0.027843 | 14 |
| REAC | REAC:R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | Fc epsilon receptor (FCERI) signaling | 3 | 0.034179 | 14 |
| REAC | REAC:R-HSA-933541 | TRAF6 mediated IRF7 activation | TRAF6 mediated IRF7 activation | 2 | 0.034475 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04010 | MAPK signaling pathway | MAPK signaling pathway | 5 | 0.000052 | 14 |
| KEGG | KEGG:04622 | RIG-I-like receptor signaling pathway | RIG-I-like receptor signaling pathway | 3 | 0.000932 | 14 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | Neurotrophin signaling pathway | 3 | 0.004279 | 14 |
| KEGG | KEGG:04380 | Osteoclast differentiation | Osteoclast differentiation | 3 | 0.005976 | 14 |
| KEGG | KEGG:05135 | Yersinia infection | Yersinia infection | 3 | 0.006531 | 14 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | Ubiquitin mediated proteolysis | 3 | 0.007119 | 14 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 3 | 0.010976 | 14 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 3 | 0.012223 | 14 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 3 | 0.019850 | 14 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | Human immunodeficiency virus 1 infection | 3 | 0.023602 | 14 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | Lipid and atherosclerosis | 3 | 0.024947 | 14 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 3 | 0.038884 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2112 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex | 2 | 0.000354 | 14 |
| CORUM | CORUM:5212 | Kinase maturation complex 2 | Kinase maturation complex 2 | 2 | 0.001648 | 14 |
| CORUM | CORUM:2074 | TRAF6 homo-oligomer complex | TRAF6 homo-oligomer complex | 1 | 0.049932 | 14 |
| CORUM | CORUM:2077 | B-raf-MAP3K11 complex | B-raf-MAP3K11 complex | 1 | 0.049932 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0035631 | CD40 receptor complex | "A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules." [GOC:BHF, PMID:20614026, PMID:9221764] | 2 | 0.000742 | 14 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 7 | 0.009560 | 14 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 2 | 0.011009 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4211 | Transcriptional cascade regulating adipogenesis | Transcriptional cascade regulating adipogenesis | 4 | 4.816377e-09 | 15 |
| WP | WP:WP4149 | White fat cell differentiation | White fat cell differentiation | 4 | 2.413917e-07 | 15 |
| WP | WP:WP236 | Adipogenesis | Adipogenesis | 5 | 4.362987e-07 | 15 |
| WP | WP:WP4879 | Overlap between signal transduction pathways contributing to LMNA laminopathies | Overlap between signal transduction pathways contributing to LMNA laminopathies | 4 | 2.639477e-06 | 15 |
| WP | WP:WP3599 | Transcription factor regulation in adipogenesis | Transcription factor regulation in adipogenesis | 3 | 3.015531e-05 | 15 |
| WP | WP:WP4844 | Influence of laminopathies on Wnt signaling | Influence of laminopathies on Wnt signaling | 3 | 1.515602e-04 | 15 |
| WP | WP:WP5474 | Catabolism of skeletal muscle in cachexia | Catabolism of skeletal muscle in cachexia | 3 | 1.925685e-04 | 15 |
| WP | WP:WP5382 | TGFB Smad signaling | TGFB Smad signaling | 2 | 2.832271e-03 | 15 |
| WP | WP:WP615 | Senescence and autophagy in cancer | Senescence and autophagy in cancer | 3 | 3.592848e-03 | 15 |
| WP | WP:WP3874 | Canonical and non canonical TGF B signaling | Canonical and non canonical TGF B signaling | 2 | 5.827301e-03 | 15 |
| WP | WP:WP3859 | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | 2 | 7.322506e-03 | 15 |
| WP | WP:WP2857 | Mesodermal commitment pathway | Mesodermal commitment pathway | 3 | 9.634755e-03 | 15 |
| WP | WP:WP5103 | Progeria associated lipodystrophy | Progeria associated lipodystrophy | 2 | 9.882757e-03 | 15 |
| WP | WP:WP4482 | Vitamin D in inflammatory diseases | Vitamin D in inflammatory diseases | 2 | 9.882757e-03 | 15 |
| WP | WP:WP2895 | Differentiation of white and brown adipocyte | Differentiation of white and brown adipocyte | 2 | 1.282301e-02 | 15 |
| WP | WP:WP3668 | Hypothesized pathways in pathogenesis of cardiovascular disease | Hypothesized pathways in pathogenesis of cardiovascular disease | 2 | 1.282301e-02 | 15 |
| WP | WP:WP5036 | Angiotensin II receptor type 1 pathway | Angiotensin II receptor type 1 pathway | 2 | 1.614220e-02 | 15 |
| WP | WP:WP2870 | Extracellular vesicle mediated signaling in recipient cells | Extracellular vesicle mediated signaling in recipient cells | 2 | 1.733263e-02 | 15 |
| WP | WP:WP5102 | Familial partial lipodystrophy | Familial partial lipodystrophy | 2 | 1.856501e-02 | 15 |
| WP | WP:WP2112 | IL17 signaling | IL17 signaling | 2 | 2.115546e-02 | 15 |
| WP | WP:WP34 | Ovarian infertility | Ovarian infertility | 2 | 3.153777e-02 | 15 |
| WP | WP:WP2817 | Mammary gland development pregnancy and lactation stage 3 of 4 | Mammary gland development pregnancy and lactation stage 3 of 4 | 2 | 4.205835e-02 | 15 |
| WP | WP:WP4535 | Envelope proteins and their potential roles in EDMD physiopathology | Envelope proteins and their potential roles in EDMD physiopathology | 2 | 4.395666e-02 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] | 6 | 2.863259e-08 | 15 |
| GO:MF | GO:0001216 | DNA-binding transcription activator activity | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] | 6 | 3.125090e-08 | 15 |
| GO:MF | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018] | 6 | 6.620536e-06 | 15 |
| GO:MF | GO:0000987 | cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018] | 6 | 7.433167e-06 | 15 |
| GO:MF | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] | 6 | 1.530865e-05 | 15 |
| GO:MF | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] | 6 | 1.722883e-05 | 15 |
| GO:MF | GO:0003700 | DNA-binding transcription factor activity | "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] | 6 | 2.231550e-05 | 15 |
| GO:MF | GO:0000976 | transcription cis-regulatory region binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] | 6 | 2.596967e-05 | 15 |
| GO:MF | GO:0001067 | transcription regulatory region nucleic acid binding | "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] | 6 | 2.607495e-05 | 15 |
| GO:MF | GO:1990837 | sequence-specific double-stranded DNA binding | "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] | 6 | 3.320671e-05 | 15 |
| GO:MF | GO:0003690 | double-stranded DNA binding | "Binding to double-stranded DNA." [GOC:elh, GOC:vw] | 6 | 4.785682e-05 | 15 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 6 | 5.017636e-05 | 15 |
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 6 | 1.351171e-04 | 15 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 6 | 6.561281e-04 | 15 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 4 | 8.102781e-04 | 15 |
| GO:MF | GO:0031490 | chromatin DNA binding | "Binding to DNA that is assembled into chromatin." [GOC:mah] | 3 | 1.320433e-03 | 15 |
| GO:MF | GO:0070411 | I-SMAD binding | "Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 2 | 1.475904e-03 | 15 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 4 | 1.827115e-03 | 15 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 4 | 2.316546e-03 | 15 |
| GO:MF | GO:0070412 | R-SMAD binding | "Binding to a receptor-regulated SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 2 | 3.991974e-03 | 15 |
| GO:MF | GO:0042803 | protein homodimerization activity | "Binding to an identical protein to form a homodimer." [GOC:jl] | 4 | 4.016696e-03 | 15 |
| GO:MF | GO:0043425 | bHLH transcription factor binding | "Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] | 2 | 6.087551e-03 | 15 |
| GO:MF | GO:0001223 | transcription coactivator binding | "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] | 2 | 1.324121e-02 | 15 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 5 | 1.331631e-02 | 15 |
| GO:MF | GO:0001222 | transcription corepressor binding | "Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc] | 2 | 1.440107e-02 | 15 |
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 3 | 1.631278e-02 | 15 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 4 | 2.195611e-02 | 15 |
| GO:MF | GO:0005518 | collagen binding | "Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732] | 2 | 2.949184e-02 | 15 |
| GO:MF | GO:0046332 | SMAD binding | "Binding to a SMAD signaling protein." [GOC:ai] | 2 | 3.758034e-02 | 15 |
| GO:MF | GO:0031962 | nuclear mineralocorticoid receptor binding | "Binding to a nuclear mineralocorticoid receptor." [GOC:mah, PMID:12511169] | 1 | 4.989139e-02 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 6 | 3.109428e-08 | 15 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 5 | 2.175658e-07 | 15 |
| GO:CC | GO:1990647 | C/EBP complex | "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121] | 2 | 1.128323e-05 | 15 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 6 | 1.185023e-05 | 15 |
| GO:CC | GO:0036488 | CHOP-C/EBP complex | "A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors." [GOC:bf, GOC:PARL, PMID:1547942] | 2 | 3.384561e-05 | 15 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 6 | 9.963091e-05 | 15 |
| GO:CC | GO:0071144 | heteromeric SMAD protein complex | "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] | 2 | 3.157022e-04 | 15 |
| GO:CC | GO:0071141 | SMAD protein complex | "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020] | 2 | 4.058539e-04 | 15 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 6 | 9.247745e-03 | 15 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 5 | 2.564275e-02 | 15 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 6 | 4.508711e-02 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9843745 | Adipogenesis | Adipogenesis | 5 | 1.112612e-07 | 15 |
| REAC | REAC:R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | Transcriptional regulation of white adipocyte differentiation | 4 | 1.005091e-05 | 15 |
| REAC | REAC:R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | Loss of Function of SMAD4 in Cancer | 2 | 1.673758e-04 | 15 |
| REAC | REAC:R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | SMAD2/3 MH2 Domain Mutants in Cancer | 2 | 1.673758e-04 | 15 |
| REAC | REAC:R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | SMAD4 MH2 Domain Mutants in Cancer | 2 | 1.673758e-04 | 15 |
| REAC | REAC:R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | RUNX3 regulates BCL2L11 (BIM) transcription | 2 | 5.576488e-04 | 15 |
| REAC | REAC:R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | Loss of Function of SMAD2/3 in Cancer | 2 | 8.362704e-04 | 15 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 6 | 8.830982e-04 | 15 |
| REAC | REAC:R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | RUNX3 regulates CDKN1A transcription | 2 | 1.170495e-03 | 15 |
| REAC | REAC:R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | Signaling by TGF-beta Receptor Complex in Cancer | 2 | 1.170495e-03 | 15 |
| REAC | REAC:R-HSA-9616222 | Transcriptional regulation of granulopoiesis | Transcriptional regulation of granulopoiesis | 3 | 2.113829e-03 | 15 |
| REAC | REAC:R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2 | 5.841131e-03 | 15 |
| REAC | REAC:R-HSA-9823730 | Formation of definitive endoderm | Formation of definitive endoderm | 2 | 5.841131e-03 | 15 |
| REAC | REAC:R-HSA-1502540 | Signaling by Activin | Signaling by Activin | 2 | 7.561987e-03 | 15 |
| REAC | REAC:R-HSA-9754189 | Germ layer formation at gastrulation | Germ layer formation at gastrulation | 2 | 7.561987e-03 | 15 |
| REAC | REAC:R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | FOXO-mediated transcription of cell cycle genes | 2 | 7.561987e-03 | 15 |
| REAC | REAC:R-HSA-1181150 | Signaling by NODAL | Signaling by NODAL | 2 | 1.404706e-02 | 15 |
| REAC | REAC:R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2 | 2.250913e-02 | 15 |
| REAC | REAC:R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 2 | 2.411108e-02 | 15 |
| REAC | REAC:R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2 | 3.486868e-02 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0001649 | osteoblast differentiation | "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid] | 5 | 8.685512e-07 | 15 |
| GO:BP | GO:0045444 | fat cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators] | 5 | 1.007455e-06 | 15 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 6 | 4.688765e-06 | 15 |
| GO:BP | GO:0001503 | ossification | "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] | 5 | 1.841552e-05 | 15 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] | 4 | 1.908873e-05 | 15 |
| GO:BP | GO:0045598 | regulation of fat cell differentiation | "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] | 4 | 2.029255e-05 | 15 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 6 | 4.011395e-05 | 15 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 6 | 4.494848e-05 | 15 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 6 | 4.843376e-05 | 15 |
| GO:BP | GO:0051094 | positive regulation of developmental process | "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 6 | 5.999992e-05 | 15 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 6 | 7.703016e-05 | 15 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 6 | 1.308372e-04 | 15 |
| GO:BP | GO:0045595 | regulation of cell differentiation | "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] | 6 | 1.569462e-04 | 15 |
| GO:BP | GO:0140467 | integrated stress response signaling | "The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041] | 3 | 1.984302e-04 | 15 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 6 | 2.447936e-04 | 15 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 6 | 2.465322e-04 | 15 |
| GO:BP | GO:0030855 | epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] | 5 | 2.885815e-04 | 15 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 3 | 3.353647e-04 | 15 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 6 | 3.915747e-04 | 15 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 3 | 5.002109e-04 | 15 |
| GO:BP | GO:0045600 | positive regulation of fat cell differentiation | "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] | 3 | 5.484768e-04 | 15 |
| GO:BP | GO:0045669 | positive regulation of osteoblast differentiation | "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] | 3 | 6.265308e-04 | 15 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 6 | 7.311660e-04 | 15 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 3 | 8.041063e-04 | 15 |
| GO:BP | GO:0061614 | miRNA transcription | "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] | 3 | 8.366155e-04 | 15 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 5 | 9.023302e-04 | 15 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 3 | 1.341744e-03 | 15 |
| GO:BP | GO:0032906 | transforming growth factor beta2 production | "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] | 2 | 1.695267e-03 | 15 |
| GO:BP | GO:0032909 | regulation of transforming growth factor beta2 production | "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] | 2 | 1.695267e-03 | 15 |
| GO:BP | GO:0001701 | in utero embryonic development | "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] | 4 | 1.904681e-03 | 15 |
| GO:BP | GO:0010586 | miRNA metabolic process | "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] | 3 | 2.199567e-03 | 15 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 6 | 2.261150e-03 | 15 |
| GO:BP | GO:0001775 | cell activation | "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators] | 5 | 2.295604e-03 | 15 |
| GO:BP | GO:0048732 | gland development | "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] | 4 | 2.776140e-03 | 15 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 6 | 3.018010e-03 | 15 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 6 | 3.125021e-03 | 15 |
| GO:BP | GO:0060429 | epithelium development | "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] | 5 | 3.578351e-03 | 15 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 6 | 3.948692e-03 | 15 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 6 | 4.082483e-03 | 15 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 6 | 4.399782e-03 | 15 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 6 | 5.096276e-03 | 15 |
| GO:BP | GO:1901203 | positive regulation of extracellular matrix assembly | "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] | 2 | 5.505425e-03 | 15 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 6 | 5.821282e-03 | 15 |
| GO:BP | GO:0001889 | liver development | "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] | 3 | 5.887538e-03 | 15 |
| GO:BP | GO:0061008 | hepaticobiliary system development | "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] | 3 | 6.255971e-03 | 15 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 6 | 8.870947e-03 | 15 |
| GO:BP | GO:0070102 | interleukin-6-mediated signaling pathway | "The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling] | 2 | 9.251677e-03 | 15 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 6 | 1.018907e-02 | 15 |
| GO:BP | GO:1901201 | regulation of extracellular matrix assembly | "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] | 2 | 1.148609e-02 | 15 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 6 | 1.300650e-02 | 15 |
| GO:BP | GO:0043009 | chordate embryonic development | "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] | 4 | 1.308128e-02 | 15 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] | 4 | 1.477716e-02 | 15 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 6 | 1.521470e-02 | 15 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] | 4 | 1.599505e-02 | 15 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 6 | 1.615853e-02 | 15 |
| GO:BP | GO:0014898 | cardiac muscle hypertrophy in response to stress | "The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] | 2 | 1.667660e-02 | 15 |
| GO:BP | GO:0014887 | cardiac muscle adaptation | "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle] | 2 | 1.667660e-02 | 15 |
| GO:BP | GO:0003299 | muscle hypertrophy in response to stress | "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart] | 2 | 1.667660e-02 | 15 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 6 | 1.670688e-02 | 15 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 6 | 2.057555e-02 | 15 |
| GO:BP | GO:0010614 | negative regulation of cardiac muscle hypertrophy | "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] | 2 | 2.120021e-02 | 15 |
| GO:BP | GO:0030325 | adrenal gland development | "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh] | 2 | 2.120021e-02 | 15 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 6 | 2.230399e-02 | 15 |
| GO:BP | GO:0014741 | negative regulation of muscle hypertrophy | "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle] | 2 | 2.451595e-02 | 15 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 6 | 2.587158e-02 | 15 |
| GO:BP | GO:1903055 | positive regulation of extracellular matrix organization | "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] | 2 | 2.626376e-02 | 15 |
| GO:BP | GO:0071634 | regulation of transforming growth factor beta production | "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah] | 2 | 2.807149e-02 | 15 |
| GO:BP | GO:0071354 | cellular response to interleukin-6 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 2 | 2.993912e-02 | 15 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 5 | 3.064666e-02 | 15 |
| GO:BP | GO:0042593 | glucose homeostasis | "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] | 3 | 3.322246e-02 | 15 |
| GO:BP | GO:0033500 | carbohydrate homeostasis | "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] | 3 | 3.360217e-02 | 15 |
| GO:BP | GO:0071604 | transforming growth factor beta production | "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3." [GOC:add, GOC:rv, PMID:16891311, PMID:2022183] | 2 | 3.385400e-02 | 15 |
| GO:BP | GO:0070741 | response to interleukin-6 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 2 | 4.017501e-02 | 15 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 5 | 4.134813e-02 | 15 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 6 | 4.156768e-02 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3740 | SKI-SMAD3-SMAD4 complex | SKI-SMAD3-SMAD4 complex | 2 | 0.000044 | 15 |
| CORUM | CORUM:3959 | SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent | SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent | 2 | 0.000044 | 15 |
| CORUM | CORUM:2706 | SMAD3-SMAD4-SP1 complex | SMAD3-SMAD4-SP1 complex | 2 | 0.000132 | 15 |
| CORUM | CORUM:2760 | SMAD3-SMAD4-FOXO3 complex | SMAD3-SMAD4-FOXO3 complex | 2 | 0.000132 | 15 |
| CORUM | CORUM:2761 | SMAD3-SMAD4-FOXO1 complex | SMAD3-SMAD4-FOXO1 complex | 2 | 0.000132 | 15 |
| CORUM | CORUM:2705 | SMAD3-SMAD4-CTCF protein-DNA complex | SMAD3-SMAD4-CTCF protein-DNA complex | 2 | 0.000132 | 15 |
| CORUM | CORUM:2708 | SMAD3-SMAD4-cJUN complex | SMAD3-SMAD4-cJUN complex | 2 | 0.000132 | 15 |
| CORUM | CORUM:3754 | CREBBP-SMAD3-SMAD4 pentameric complex | CREBBP-SMAD3-SMAD4 pentameric complex | 2 | 0.000132 | 15 |
| CORUM | CORUM:2762 | SMAD3-SMAD4-FOXO4 complex | SMAD3-SMAD4-FOXO4 complex | 2 | 0.000132 | 15 |
| CORUM | CORUM:6649 | SMAD3-SMAD4-WWTR1 complex | SMAD3-SMAD4-WWTR1 complex | 2 | 0.000132 | 15 |
| CORUM | CORUM:2834 | SMAD4-SMAD2-SMAD3 complex | SMAD4-SMAD2-SMAD3 complex | 2 | 0.000132 | 15 |
| CORUM | CORUM:2692 | SMAD3-SMAD4-cJun-cFos complex | SMAD3-SMAD4-cJun-cFos complex | 2 | 0.000264 | 15 |
| CORUM | CORUM:2707 | SMAD3-SMAD4-FOXO3-FOXG1 complex | SMAD3-SMAD4-FOXO3-FOXG1 complex | 2 | 0.000264 | 15 |
| CORUM | CORUM:2754 | JUND-FOSB-SMAD3-SMAD4 complex | JUND-FOSB-SMAD3-SMAD4 complex | 2 | 0.000264 | 15 |
| CORUM | CORUM:1474 | SMAD3/4-E2F4/5-p107-DP1 complex | SMAD3/4-E2F4/5-p107-DP1 complex | 2 | 0.000660 | 15 |
| CORUM | CORUM:2829 | RSmad complex | RSmad complex | 2 | 0.001977 | 15 |
| CORUM | CORUM:3733 | SKI-SMAD3 complex | SKI-SMAD3 complex | 1 | 0.049680 | 15 |
| CORUM | CORUM:3200 | SMAD4-SKI complex | SMAD4-SKI complex | 1 | 0.049680 | 15 |
| CORUM | CORUM:3199 | SKI-SMAD3 complex | SKI-SMAD3 complex | 1 | 0.049680 | 15 |
| CORUM | CORUM:3197 | SMAD4-SNO-SKI complex | SMAD4-SNO-SKI complex | 1 | 0.049680 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-145-5p | hsa-mir-145-5p | hsa-mir-145-5p | 3 | 0.023042 | 15 |
| MIRNA | MIRNA:hsa-mir-182-3p | hsa-mir-182-3p | hsa-mir-182-3p | 2 | 0.033264 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0200146 | Mucoid extracellular matrix accumulation | An increase of medial mucoid extracellular matrix creating translamellar and/or intralamellar expansions including extracellular pools as noted on an H&E stain and/or a stain to highlight extracellular matrix material (Movat's pentachrome, Alcian blue, etc.). | 2 | 0.028340 | 15 |
| HP | HP:0032079 | Medial degeneration | Medial degeneration of the aorta is to be used as an overarching term for any aortic surgical specimens that demonstrate one or more of the specific histopathologies mucoid extracellular matrix accumulation, elastic fiber fragmentation and/or loss, elastic fiber thinning, elastic fiber disorganization, smooth muscle cell nuclei loss, laminar medial collapse, smooth muscle cell disorganization, medial fibrosis. Grading of medial degeneration is based on the average overall severity of specific histopathologies as described, considering the worst area(s) sampled from multiple slides and aorta sections. | 2 | 0.028340 | 15 |
| HP | HP:0004959 | Descending thoracic aorta aneurysm | An abnormal localized widening (dilatation) of the descending thoracic aorta. | 2 | 0.028340 | 15 |
| HP | HP:0012180 | Cystic medial necrosis | A disorder of large arteries, in particular the aorta, characterized by an accumulation of basophilic ground substance in the media with cyst-like lesions associated with degenerative changes of collagen, elastin and the vascular smooth muscle cells. | 2 | 0.028340 | 15 |
| HP | HP:0012763 | Paroxysmal dyspnea | A sudden attack of dyspnea that occurs while the affected person is at rest. | 2 | 0.031485 | 15 |
| HP | HP:0012499 | Descending aortic dissection | A separation of the layers within the wall of the descending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space. | 2 | 0.034795 | 15 |
| HP | HP:0012163 | Carotid artery dilatation | A dilatation (balooning or bulging out of the vessel wall) of a carotid artery. | 2 | 0.041909 | 15 |
| HP | HP:0005112 | Abdominal aortic aneurysm | An abnormal localized widening (dilatation) of the abdominal aorta. | 2 | 0.045712 | 15 |
| HP | HP:0100775 | Dural ectasia | A widening or ballooning of the dural sac surrounding the spinal cord usually at the lumbosacral level. | 2 | 0.045712 | 15 |
| HP | HP:0012432 | Chronic fatigue | Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer. | 2 | 0.049681 | 15 |
| HP | HP:0010303 | Abnormal spinal meningeal morphology | Any abnormality of the spinal meninges, the system of membranes (dura mater, the arachnoid mater, and the pia mater) which envelops the spinal cord. | 2 | 0.049681 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 2 | 0.03815 | 15 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 2 | 0.03815 | 15 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 2 | 0.04881 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] | 6 | 9.629707e-09 | 16 |
| GO:BP | GO:0008286 | insulin receptor signaling pathway | "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] | 5 | 3.507164e-08 | 16 |
| GO:BP | GO:0043434 | response to peptide hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] | 6 | 7.251041e-08 | 16 |
| GO:BP | GO:0032869 | cellular response to insulin stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 5 | 4.683628e-07 | 16 |
| GO:BP | GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] | 6 | 6.252715e-07 | 16 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] | 6 | 6.811391e-07 | 16 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 6 | 7.274137e-07 | 16 |
| GO:BP | GO:0032868 | response to insulin | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 5 | 1.784077e-06 | 16 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 6 | 5.662375e-06 | 16 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194] | 6 | 8.481129e-06 | 16 |
| GO:BP | GO:1901698 | response to nitrogen compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 6 | 1.618275e-05 | 16 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 6 | 2.784433e-05 | 16 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] | 6 | 3.418031e-05 | 16 |
| GO:BP | GO:0046326 | positive regulation of D-glucose import | "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai, GOC:dph, GOC:tb] | 3 | 8.201980e-05 | 16 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 6 | 1.115680e-04 | 16 |
| GO:BP | GO:0010828 | positive regulation of D-glucose transmembrane transport | "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] | 3 | 1.520083e-04 | 16 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 6 | 2.215044e-04 | 16 |
| GO:BP | GO:0048009 | insulin-like growth factor receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb] | 3 | 2.388402e-04 | 16 |
| GO:BP | GO:0046324 | regulation of D-glucose import | "Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] | 3 | 3.177480e-04 | 16 |
| GO:BP | GO:0046626 | regulation of insulin receptor signaling pathway | "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] | 3 | 5.484768e-04 | 16 |
| GO:BP | GO:1900076 | regulation of cellular response to insulin stimulus | "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] | 3 | 6.824678e-04 | 16 |
| GO:BP | GO:0010827 | regulation of D-glucose transmembrane transport | "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] | 3 | 7.724482e-04 | 16 |
| GO:BP | GO:0046323 | D-glucose import | "The directed movement of the hexose monosaccharide D-glucose into a cell or organelle." [GOC:ai] | 3 | 7.724482e-04 | 16 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 6 | 1.139255e-03 | 16 |
| GO:BP | GO:0007173 | epidermal growth factor receptor signaling pathway | "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb] | 3 | 2.327174e-03 | 16 |
| GO:BP | GO:0007229 | integrin-mediated signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] | 3 | 2.886709e-03 | 16 |
| GO:BP | GO:1904659 | D-glucose transmembrane transport | "The process in which D-glucose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050] | 3 | 2.886709e-03 | 16 |
| GO:BP | GO:0008645 | hexose transmembrane transport | "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule." [GOC:vw] | 3 | 3.117577e-03 | 16 |
| GO:BP | GO:0015749 | monosaccharide transmembrane transport | "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GO_REF:0000069, GOC:TermGenie, GOC:vw] | 3 | 3.360383e-03 | 16 |
| GO:BP | GO:0038127 | ERBB signaling pathway | "The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, Wikipedia:ErbB] | 3 | 3.975018e-03 | 16 |
| GO:BP | GO:0034219 | carbohydrate transmembrane transport | "The process in which a carbohydrate is transported across a membrane." [GOC:mah] | 3 | 4.456899e-03 | 16 |
| GO:BP | GO:0008643 | carbohydrate transport | "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] | 3 | 4.869163e-03 | 16 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 6 | 5.161904e-03 | 16 |
| GO:BP | GO:0034764 | positive regulation of transmembrane transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] | 3 | 1.527224e-02 | 16 |
| GO:BP | GO:0046628 | positive regulation of insulin receptor signaling pathway | "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf] | 2 | 1.667660e-02 | 16 |
| GO:BP | GO:0060396 | growth hormone receptor signaling pathway | "The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph, PMID:11445442] | 2 | 1.963231e-02 | 16 |
| GO:BP | GO:1900078 | positive regulation of cellular response to insulin stimulus | "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] | 2 | 1.963231e-02 | 16 |
| GO:BP | GO:0071378 | cellular response to growth hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:mah] | 2 | 2.120021e-02 | 16 |
| GO:BP | GO:0048011 | neurotrophin TRK receptor signaling pathway | "The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:ceb, GOC:jc, GOC:signaling, PMID:12065629, Wikipedia:Trk_receptor] | 2 | 2.120021e-02 | 16 |
| GO:BP | GO:0042593 | glucose homeostasis | "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] | 3 | 3.322246e-02 | 16 |
| GO:BP | GO:0033500 | carbohydrate homeostasis | "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] | 3 | 3.360217e-02 | 16 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 6 | 3.675180e-02 | 16 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 6 | 4.175568e-02 | 16 |
| GO:BP | GO:0046627 | negative regulation of insulin receptor signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] | 2 | 4.468788e-02 | 16 |
| GO:BP | GO:0060416 | response to growth hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:BHF, GOC:dph] | 2 | 4.468788e-02 | 16 |
| GO:BP | GO:0007162 | negative regulation of cell adhesion | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] | 3 | 4.636677e-02 | 16 |
| GO:BP | GO:1900077 | negative regulation of cellular response to insulin stimulus | "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] | 2 | 4.703390e-02 | 16 |
| GO:BP | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | "An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway." [PMID:20517722, PMID:22952397] | 3 | 4.925222e-02 | 16 |
| GO:BP | GO:0038179 | neurotrophin signaling pathway | "The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons." [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, Wikipedia:Neurotrophin] | 2 | 4.943962e-02 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4659 | Gastrin signaling | Gastrin signaling | 5 | 3.302504e-08 | 16 |
| WP | WP:WP244 | Alpha 6 beta 4 signaling | Alpha 6 beta 4 signaling | 4 | 8.031539e-08 | 16 |
| WP | WP:WP2034 | Leptin signaling | Leptin signaling | 4 | 1.900424e-06 | 16 |
| WP | WP:WP2037 | Prolactin signaling | Prolactin signaling | 4 | 2.249891e-06 | 16 |
| WP | WP:WP437 | EGF EGFR signaling | EGF EGFR signaling | 4 | 4.849070e-05 | 16 |
| WP | WP:WP5493 | Effect of dasatinib on the BCR ABL signaling pathway | Effect of dasatinib on the BCR ABL signaling pathway | 3 | 1.212815e-04 | 16 |
| WP | WP:WP395 | IL4 signaling | IL4 signaling | 3 | 1.673765e-04 | 16 |
| WP | WP:WP585 | Interferon type I signaling | Interferon type I signaling | 3 | 2.116709e-04 | 16 |
| WP | WP:WP2374 | Oncostatin M signaling | Oncostatin M signaling | 3 | 2.364739e-04 | 16 |
| WP | WP:WP4205 | MET in type 1 papillary renal cell carcinoma | MET in type 1 papillary renal cell carcinoma | 3 | 2.631359e-04 | 16 |
| WP | WP:WP3303 | RAC1 PAK1 p38 MMP2 pathway | RAC1 PAK1 p38 MMP2 pathway | 3 | 4.266469e-04 | 16 |
| WP | WP:WP4582 | Cancer immunotherapy by CTLA4 blockade | Cancer immunotherapy by CTLA4 blockade | 2 | 2.278669e-03 | 16 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 4 | 2.656716e-03 | 16 |
| WP | WP:WP2380 | Brain derived neurotrophic factor BDNF signaling | Brain derived neurotrophic factor BDNF signaling | 3 | 3.526591e-03 | 16 |
| WP | WP:WP51 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 3 | 4.535482e-03 | 16 |
| WP | WP:WP481 | Insulin signaling | Insulin signaling | 3 | 5.613106e-03 | 16 |
| WP | WP:WP3929 | Chemokine signaling | Chemokine signaling | 3 | 6.154139e-03 | 16 |
| WP | WP:WP5181 | Roles of ceramides in development of insulin resistance | Roles of ceramides in development of insulin resistance | 2 | 6.322170e-03 | 16 |
| WP | WP:WP306 | Focal adhesion | Focal adhesion | 3 | 1.060588e-02 | 16 |
| WP | WP:WP5490 | Inhibition of GNAQ regulated signaling in uveal melanoma | Inhibition of GNAQ regulated signaling in uveal melanoma | 2 | 1.316392e-02 | 16 |
| WP | WP:WP313 | Hepatocyte growth factor receptor signaling | Hepatocyte growth factor receptor signaling | 2 | 1.398346e-02 | 16 |
| WP | WP:WP127 | IL5 signaling | IL5 signaling | 2 | 1.658929e-02 | 16 |
| WP | WP:WP49 | IL2 signaling | IL2 signaling | 2 | 1.658929e-02 | 16 |
| WP | WP:WP5497 | Cyclin dependent kinase 4 6 inhibitors in breast cancer | Cyclin dependent kinase 4 6 inhibitors in breast cancer | 2 | 1.750691e-02 | 16 |
| WP | WP:WP5215 | Targeted agents in triple negative breast cancer | Targeted agents in triple negative breast cancer | 2 | 1.750691e-02 | 16 |
| WP | WP:WP2526 | PDGF pathway | PDGF pathway | 2 | 1.941555e-02 | 16 |
| WP | WP:WP364 | IL6 signaling | IL6 signaling | 2 | 2.246179e-02 | 16 |
| WP | WP:WP5300 | TROP2 regulatory signaling | TROP2 regulatory signaling | 2 | 2.352601e-02 | 16 |
| WP | WP:WP2332 | IL11 signaling | IL11 signaling | 2 | 2.352601e-02 | 16 |
| WP | WP:WP286 | IL3 signaling | IL3 signaling | 2 | 2.802645e-02 | 16 |
| WP | WP:WP2018 | RANKL RANK signaling | RANKL RANK signaling | 2 | 3.042258e-02 | 16 |
| WP | WP:WP4747 | Netrin UNC5B signaling | Netrin UNC5B signaling | 2 | 3.291579e-02 | 16 |
| WP | WP:WP5144 | NRP1 triggered signaling in pancreatic cancer | NRP1 triggered signaling in pancreatic cancer | 2 | 3.419877e-02 | 16 |
| WP | WP:WP304 | Kit receptor signaling | Kit receptor signaling | 2 | 3.419877e-02 | 16 |
| WP | WP:WP195 | IL1 signaling | IL1 signaling | 2 | 3.550596e-02 | 16 |
| WP | WP:WP3932 | Focal adhesion PI3K Akt mTOR signaling | Focal adhesion PI3K Akt mTOR signaling | 3 | 3.714957e-02 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 6 | 3.254662e-07 | 16 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 6 | 6.106263e-07 | 16 |
| GO:MF | GO:0005158 | insulin receptor binding | "Binding to an insulin receptor." [GOC:ai] | 3 | 3.741491e-06 | 16 |
| GO:MF | GO:0001784 | phosphotyrosine residue binding | "Binding to a phosphorylated tyrosine residue within a protein." [PMID:14636584] | 3 | 3.928555e-05 | 16 |
| GO:MF | GO:0030159 | signaling receptor complex adaptor activity | "The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah] | 3 | 4.747084e-05 | 16 |
| GO:MF | GO:0045309 | protein phosphorylated amino acid binding | "Binding to a phosphorylated amino acid residue within a protein." [GOC:go_curators] | 3 | 7.865735e-05 | 16 |
| GO:MF | GO:0030971 | receptor tyrosine kinase binding | "Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah] | 3 | 2.059312e-04 | 16 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 6 | 2.125165e-04 | 16 |
| GO:MF | GO:0051219 | phosphoprotein binding | "Binding to a phosphorylated protein." [GOC:ai] | 3 | 3.127890e-04 | 16 |
| GO:MF | GO:0035591 | signaling adaptor activity | "The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498] | 3 | 6.919850e-04 | 16 |
| GO:MF | GO:1990782 | protein tyrosine kinase binding | "Binding to protein tyrosine kinase." [PMID:25499537] | 3 | 8.005282e-04 | 16 |
| GO:MF | GO:0005159 | insulin-like growth factor receptor binding | "Binding to an insulin-like growth factor receptor." [GOC:jl] | 2 | 1.475904e-03 | 16 |
| GO:MF | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity | "The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848] | 2 | 1.672470e-03 | 16 |
| GO:MF | GO:0043548 | phosphatidylinositol 3-kinase binding | "Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069] | 2 | 3.991974e-03 | 16 |
| GO:MF | GO:0042169 | SH2 domain binding | "Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017] | 2 | 1.005216e-02 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | Leukocyte transendothelial migration | 4 | 0.000008 | 16 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | Growth hormone synthesis, secretion and action | 4 | 0.000009 | 16 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | Bacterial invasion of epithelial cells | 3 | 0.000348 | 16 |
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 3 | 0.000965 | 16 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | Neurotrophin signaling pathway | 3 | 0.001260 | 16 |
| KEGG | KEGG:05135 | Yersinia infection | Yersinia infection | 3 | 0.001929 | 16 |
| KEGG | KEGG:04148 | Efferocytosis | Efferocytosis | 3 | 0.002910 | 16 |
| KEGG | KEGG:04360 | Axon guidance | Axon guidance | 3 | 0.004537 | 16 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | Chemokine signaling pathway | 3 | 0.005243 | 16 |
| KEGG | KEGG:04510 | Focal adhesion | Focal adhesion | 3 | 0.006293 | 16 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 3 | 0.006576 | 16 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | Chemical carcinogenesis - reactive oxygen species | 3 | 0.008224 | 16 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 3 | 0.008447 | 16 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 3 | 0.008906 | 16 |
| KEGG | KEGG:04960 | Aldosterone-regulated sodium reabsorption | Aldosterone-regulated sodium reabsorption | 2 | 0.008998 | 16 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 3 | 0.011307 | 16 |
| KEGG | KEGG:04930 | Type II diabetes mellitus | Type II diabetes mellitus | 2 | 0.013953 | 16 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | Regulation of lipolysis in adipocytes | 2 | 0.022222 | 16 |
| KEGG | KEGG:04370 | VEGF signaling pathway | VEGF signaling pathway | 2 | 0.022996 | 16 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | Longevity regulating pathway - multiple species | 2 | 0.024584 | 16 |
| KEGG | KEGG:05211 | Renal cell carcinoma | Renal cell carcinoma | 2 | 0.030551 | 16 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | Adipocytokine signaling pathway | 2 | 0.032373 | 16 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 3 | 0.033720 | 16 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 2 | 0.038150 | 16 |
| KEGG | KEGG:04012 | ErbB signaling pathway | ErbB signaling pathway | 2 | 0.046576 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-186763 | Downstream signal transduction | Downstream signal transduction | 3 | 0.000053 | 16 |
| REAC | REAC:R-HSA-109704 | PI3K Cascade | PI3K Cascade | 3 | 0.000144 | 16 |
| REAC | REAC:R-HSA-112399 | IRS-mediated signalling | IRS-mediated signalling | 3 | 0.000184 | 16 |
| REAC | REAC:R-HSA-2428928 | IRS-related events triggered by IGF1R | IRS-related events triggered by IGF1R | 3 | 0.000248 | 16 |
| REAC | REAC:R-HSA-2428924 | IGF1R signaling cascade | IGF1R signaling cascade | 3 | 0.000248 | 16 |
| REAC | REAC:R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 3 | 0.000266 | 16 |
| REAC | REAC:R-HSA-74751 | Insulin receptor signalling cascade | Insulin receptor signalling cascade | 3 | 0.000285 | 16 |
| REAC | REAC:R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | Signaling by Receptor Tyrosine Kinases | 5 | 0.000289 | 16 |
| REAC | REAC:R-HSA-186797 | Signaling by PDGF | Signaling by PDGF | 3 | 0.000498 | 16 |
| REAC | REAC:R-HSA-9603381 | Activated NTRK3 signals through PI3K | Activated NTRK3 signals through PI3K | 2 | 0.000836 | 16 |
| REAC | REAC:R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | Constitutive Signaling by Aberrant PI3K in Cancer | 3 | 0.000875 | 16 |
| REAC | REAC:R-HSA-76002 | Platelet activation, signaling and aggregation | Platelet activation, signaling and aggregation | 4 | 0.000976 | 16 |
| REAC | REAC:R-HSA-5684996 | MAPK1/MAPK3 signaling | MAPK1/MAPK3 signaling | 4 | 0.001169 | 16 |
| REAC | REAC:R-HSA-74752 | Signaling by Insulin receptor | Signaling by Insulin receptor | 3 | 0.001244 | 16 |
| REAC | REAC:R-HSA-6806834 | Signaling by MET | Signaling by MET | 3 | 0.001405 | 16 |
| REAC | REAC:R-HSA-5683057 | MAPK family signaling cascades | MAPK family signaling cascades | 4 | 0.001996 | 16 |
| REAC | REAC:R-HSA-2586552 | Signaling by Leptin | Signaling by Leptin | 2 | 0.002006 | 16 |
| REAC | REAC:R-HSA-198203 | PI3K/AKT activation | PI3K/AKT activation | 2 | 0.002006 | 16 |
| REAC | REAC:R-HSA-2219528 | PI3K/AKT Signaling in Cancer | PI3K/AKT Signaling in Cancer | 3 | 0.002421 | 16 |
| REAC | REAC:R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3 | 0.002502 | 16 |
| REAC | REAC:R-HSA-4420097 | VEGFA-VEGFR2 Pathway | VEGFA-VEGFR2 Pathway | 3 | 0.002669 | 16 |
| REAC | REAC:R-HSA-9842663 | Signaling by LTK | Signaling by LTK | 2 | 0.003063 | 16 |
| REAC | REAC:R-HSA-199418 | Negative regulation of the PI3K/AKT network | Negative regulation of the PI3K/AKT network | 3 | 0.003120 | 16 |
| REAC | REAC:R-HSA-194138 | Signaling by VEGF | Signaling by VEGF | 3 | 0.003619 | 16 |
| REAC | REAC:R-HSA-5654710 | PI-3K cascade:FGFR3 | PI-3K cascade:FGFR3 | 2 | 0.004341 | 16 |
| REAC | REAC:R-HSA-9034015 | Signaling by NTRK3 (TRKC) | Signaling by NTRK3 (TRKC) | 2 | 0.005064 | 16 |
| REAC | REAC:R-HSA-391160 | Signal regulatory protein family interactions | Signal regulatory protein family interactions | 2 | 0.005064 | 16 |
| REAC | REAC:R-HSA-5654689 | PI-3K cascade:FGFR1 | PI-3K cascade:FGFR1 | 2 | 0.005841 | 16 |
| REAC | REAC:R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | Signaling by FLT3 ITD and TKD mutants | 2 | 0.005841 | 16 |
| REAC | REAC:R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | p130Cas linkage to MAPK signaling for integrins | 2 | 0.005841 | 16 |
| REAC | REAC:R-HSA-210993 | Tie2 Signaling | Tie2 Signaling | 2 | 0.006674 | 16 |
| REAC | REAC:R-HSA-180292 | GAB1 signalosome | GAB1 signalosome | 2 | 0.006674 | 16 |
| REAC | REAC:R-HSA-166520 | Signaling by NTRKs | Signaling by NTRKs | 3 | 0.007072 | 16 |
| REAC | REAC:R-HSA-5654720 | PI-3K cascade:FGFR4 | PI-3K cascade:FGFR4 | 2 | 0.007562 | 16 |
| REAC | REAC:R-HSA-5654708 | Downstream signaling of activated FGFR3 | Downstream signaling of activated FGFR3 | 2 | 0.008505 | 16 |
| REAC | REAC:R-HSA-5654695 | PI-3K cascade:FGFR2 | PI-3K cascade:FGFR2 | 2 | 0.008505 | 16 |
| REAC | REAC:R-HSA-1500931 | Cell-Cell communication | Cell-Cell communication | 3 | 0.010853 | 16 |
| REAC | REAC:R-HSA-9006115 | Signaling by NTRK2 (TRKB) | Signaling by NTRK2 (TRKB) | 2 | 0.011665 | 16 |
| REAC | REAC:R-HSA-5654716 | Downstream signaling of activated FGFR4 | Downstream signaling of activated FGFR4 | 2 | 0.012829 | 16 |
| REAC | REAC:R-HSA-5654687 | Downstream signaling of activated FGFR1 | Downstream signaling of activated FGFR1 | 2 | 0.014047 | 16 |
| REAC | REAC:R-HSA-5654696 | Downstream signaling of activated FGFR2 | Downstream signaling of activated FGFR2 | 2 | 0.014047 | 16 |
| REAC | REAC:R-HSA-354192 | Integrin signaling | Integrin signaling | 2 | 0.018032 | 16 |
| REAC | REAC:R-HSA-9682385 | FLT3 signaling in disease | FLT3 signaling in disease | 2 | 0.019469 | 16 |
| REAC | REAC:R-HSA-201556 | Signaling by ALK | Signaling by ALK | 2 | 0.020962 | 16 |
| REAC | REAC:R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | Signaling by CSF1 (M-CSF) in myeloid cells | 2 | 0.024111 | 16 |
| REAC | REAC:R-HSA-5654741 | Signaling by FGFR3 | Signaling by FGFR3 | 2 | 0.027479 | 16 |
| REAC | REAC:R-HSA-114604 | GPVI-mediated activation cascade | GPVI-mediated activation cascade | 2 | 0.032940 | 16 |
| REAC | REAC:R-HSA-5654743 | Signaling by FGFR4 | Signaling by FGFR4 | 2 | 0.032940 | 16 |
| REAC | REAC:R-HSA-9607240 | FLT3 Signaling | FLT3 Signaling | 2 | 0.034869 | 16 |
| REAC | REAC:R-HSA-1266695 | Interleukin-7 signaling | Interleukin-7 signaling | 2 | 0.036852 | 16 |
| REAC | REAC:R-HSA-76009 | Platelet Aggregation (Plug Formation) | Platelet Aggregation (Plug Formation) | 2 | 0.038890 | 16 |
| REAC | REAC:R-HSA-8853659 | RET signaling | RET signaling | 2 | 0.038890 | 16 |
| REAC | REAC:R-HSA-1433557 | Signaling by SCF-KIT | Signaling by SCF-KIT | 2 | 0.040982 | 16 |
| REAC | REAC:R-HSA-109582 | Hemostasis | Hemostasis | 4 | 0.042922 | 16 |
| REAC | REAC:R-HSA-5654736 | Signaling by FGFR1 | Signaling by FGFR1 | 2 | 0.049894 | 16 |
| REAC | REAC:R-HSA-373752 | Netrin-1 signaling | Netrin-1 signaling | 2 | 0.049894 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5282 | CAS-SRC-FAK complex | CAS-SRC-FAK complex | 2 | 0.000059 | 16 |
| CORUM | CORUM:2551 | PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated | PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated | 2 | 0.000177 | 16 |
| CORUM | CORUM:6921 | FAK–p130Cas–MT1 complex | FAK–p130Cas–MT1 complex | 2 | 0.000177 | 16 |
| CORUM | CORUM:2470 | p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex | p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex | 2 | 0.000177 | 16 |
| CORUM | CORUM:2577 | Sam68-p85 P13K-IRS-1-IR signaling complex | Sam68-p85 P13K-IRS-1-IR signaling complex | 2 | 0.000354 | 16 |
| CORUM | CORUM:5177 | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | 2 | 0.001237 | 16 |
| CORUM | CORUM:2480 | CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) | CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) | 2 | 0.001237 | 16 |
| CORUM | CORUM:3183 | PDGFRA-SHP-2 complex, PDGF stimulated | PDGFRA-SHP-2 complex, PDGF stimulated | 1 | 0.049932 | 16 |
| CORUM | CORUM:2574 | CD19-VAV1-PIK3R1 complex | CD19-VAV1-PIK3R1 complex | 1 | 0.049932 | 16 |
| CORUM | CORUM:7361 | ARAF-PIK3R1 complex | ARAF-PIK3R1 complex | 1 | 0.049932 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4299 | hsa-mir-4299 | hsa-mir-4299 | 4 | 0.032214 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0032797 | SMN complex | "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415] | 3 | 5.033098e-08 | 17 |
| GO:CC | GO:0034719 | SMN-Sm protein complex | "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408] | 3 | 2.488506e-07 | 17 |
| GO:CC | GO:0097504 | Gemini of Cajal bodies | "Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA)." [GOC:pr, PMID:11031238, PMID:9683623, Wikipedia:Cell_nucleus#Cajal_bodies_and_gems] | 2 | 2.228622e-04 | 17 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1751 | SMN complex | SMN complex | 3 | 0.000001 | 17 |
| CORUM | CORUM:1143 | SMN complex | SMN complex | 3 | 0.000009 | 17 |
| CORUM | CORUM:824 | Anti-SMN protein complex | Anti-SMN protein complex | 2 | 0.000132 | 17 |
| CORUM | CORUM:3296 | SMN complex (GEMIN5,4,3), SMN-independent intermediate | SMN complex (GEMIN5,4,3), SMN-independent intermediate | 2 | 0.000132 | 17 |
| CORUM | CORUM:1750 | PPP4C-PPP4R2-Gemin3-Gemin4 complex | PPP4C-PPP4R2-Gemin3-Gemin4 complex | 2 | 0.000264 | 17 |
| CORUM | CORUM:3284 | SMN complex (GEMIN2, GEMIN3, GEMIN4, GEMIN5, SMN) | SMN complex (GEMIN2, GEMIN3, GEMIN4, GEMIN5, SMN) | 2 | 0.000264 | 17 |
| CORUM | CORUM:832 | Anti-Sm protein complex | Anti-Sm protein complex | 2 | 0.000440 | 17 |
| CORUM | CORUM:1752 | SMN complex | SMN complex | 2 | 0.000660 | 17 |
| CORUM | CORUM:1749 | SMN-PolII-RHA complex | SMN-PolII-RHA complex | 2 | 0.001231 | 17 |
| CORUM | CORUM:1745 | SMN complex | SMN complex | 2 | 0.003991 | 17 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-194441 | Metabolism of non-coding RNA | Metabolism of non-coding RNA | 2 | 0.011538 | 17 |
| REAC | REAC:R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | SARS-CoV-2 modulates host translation machinery | 2 | 0.011538 | 17 |
| REAC | REAC:R-HSA-191859 | snRNP Assembly | snRNP Assembly | 2 | 0.011538 | 17 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-444257 | RSK activation | RSK activation | 2 | 0.000191 | 18 |
| REAC | REAC:R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | Gastrin-CREB signalling pathway via PKC and MAPK | 2 | 0.000952 | 18 |
| REAC | REAC:R-HSA-198753 | ERK/MAPK targets | ERK/MAPK targets | 2 | 0.002094 | 18 |
| REAC | REAC:R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2 | 0.002719 | 18 |
| REAC | REAC:R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | MAPK targets/ Nuclear events mediated by MAP kinases | 2 | 0.003941 | 18 |
| REAC | REAC:R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activity | Transcriptional and post-translational regulation of MITF-M expression and activity | 2 | 0.006032 | 18 |
| REAC | REAC:R-HSA-437239 | Recycling pathway of L1 | Recycling pathway of L1 | 2 | 0.010209 | 18 |
| REAC | REAC:R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | Nuclear Events (kinase and transcription factor activation) | 2 | 0.016008 | 18 |
| REAC | REAC:R-HSA-450294 | MAP kinase activation | MAP kinase activation | 2 | 0.017100 | 18 |
| REAC | REAC:R-HSA-448424 | Interleukin-17 signaling | Interleukin-17 signaling | 2 | 0.021828 | 18 |
| REAC | REAC:R-HSA-438064 | Post NMDA receptor activation events | Post NMDA receptor activation events | 2 | 0.025075 | 18 |
| REAC | REAC:R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | Activation of NMDA receptors and postsynaptic events | 2 | 0.034562 | 18 |
| REAC | REAC:R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | Toll Like Receptor 5 (TLR5) Cascade | 2 | 0.040296 | 18 |
| REAC | REAC:R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | Toll Like Receptor 10 (TLR10) Cascade | 2 | 0.040296 | 18 |
| REAC | REAC:R-HSA-975871 | MyD88 cascade initiated on plasma membrane | MyD88 cascade initiated on plasma membrane | 2 | 0.040296 | 18 |
| REAC | REAC:R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2 | 0.044660 | 18 |
| REAC | REAC:R-HSA-975155 | MyD88 dependent cascade initiated on endosome | MyD88 dependent cascade initiated on endosome | 2 | 0.045559 | 18 |
| REAC | REAC:R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2 | 0.046467 | 18 |
| REAC | REAC:R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | Toll Like Receptor 3 (TLR3) Cascade | 2 | 0.047385 | 18 |
| REAC | REAC:R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | Toll Like Receptor 9 (TLR9) Cascade | 2 | 0.049246 | 18 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5231 | Hippocampal synaptogenesis and neurogenesis | Hippocampal synaptogenesis and neurogenesis | 2 | 0.003640 | 18 |
| WP | WP:WP3676 | BDNF TrkB signaling | BDNF TrkB signaling | 2 | 0.006954 | 18 |
| WP | WP:WP4877 | Host pathogen interaction of human coronaviruses MAPK signaling | Host pathogen interaction of human coronaviruses MAPK signaling | 2 | 0.008294 | 18 |
| WP | WP:WP127 | IL5 signaling | IL5 signaling | 2 | 0.008766 | 18 |
| WP | WP:WP2332 | IL11 signaling | IL11 signaling | 2 | 0.012439 | 18 |
| WP | WP:WP5493 | Effect of dasatinib on the BCR ABL signaling pathway | Effect of dasatinib on the BCR ABL signaling pathway | 2 | 0.013015 | 18 |
| WP | WP:WP4566 | Translation inhibitors in chronically activated PDGFRA cells | Translation inhibitors in chronically activated PDGFRA cells | 2 | 0.013605 | 18 |
| WP | WP:WP304 | Kit receptor signaling | Kit receptor signaling | 2 | 0.018094 | 18 |
| WP | WP:WP5510 | 16p12 2 copy number variation syndrome 520kb | 16p12 2 copy number variation syndrome 520kb | 2 | 0.018787 | 18 |
| WP | WP:WP2032 | Thyroid stimulating hormone TSH signaling | Thyroid stimulating hormone TSH signaling | 2 | 0.021688 | 18 |
| WP | WP:WP2034 | Leptin signaling | Leptin signaling | 2 | 0.032540 | 18 |
| WP | WP:WP5094 | Orexin receptor pathway | Orexin receptor pathway | 2 | 0.049995 | 18 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04720 | Long-term potentiation | Long-term potentiation | 2 | 0.009078 | 18 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | Progesterone-mediated oocyte maturation | 2 | 0.021092 | 18 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | Neurotrophin signaling pathway | 2 | 0.028230 | 18 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 2 | 0.034786 | 18 |
| KEGG | KEGG:05135 | Yersinia infection | Yersinia infection | 2 | 0.037488 | 18 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 2 | 0.048665 | 18 |
| KEGG | KEGG:04150 | mTOR signaling pathway | mTOR signaling pathway | 2 | 0.048665 | 18 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0030522 | intracellular receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a receptor located within a cell." [GOC:bf, GOC:mah] | 4 | 0.000398 | 19 |
| GO:BP | GO:0140861 | DNA repair-dependent chromatin remodeling | "A chromatin remodeling process that allows DNA repair enzyme to access genomic DNA and repair DNA lesions." [PMID:15528408, PMID:28053344, PMID:29095668, PMID:35689883] | 2 | 0.008279 | 19 |
| GO:BP | GO:0043392 | negative regulation of DNA binding | "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] | 2 | 0.014540 | 19 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 5 | 0.022563 | 19 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 5 | 0.027418 | 19 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 5 | 0.044128 | 19 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5357786 | TNFR1-induced proapoptotic signaling | TNFR1-induced proapoptotic signaling | 2 | 0.005025 | 19 |
| REAC | REAC:R-HSA-5357905 | Regulation of TNFR1 signaling | Regulation of TNFR1 signaling | 2 | 0.017294 | 19 |
| REAC | REAC:R-HSA-75893 | TNF signaling | TNF signaling | 2 | 0.024786 | 19 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4320 | Effect of progerin on genes involved in progeria | Effect of progerin on genes involved in progeria | 2 | 0.016589 | 19 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0043130 | ubiquitin binding | "Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd] | 2 | 0.048422 | 19 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2160 | AOF2-AR complex | AOF2-AR complex | 1 | 0.049932 | 19 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | Central carbon metabolism in cancer | 2 | 0.021395 | 20 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4709-3p | hsa-mir-4709-3p | hsa-mir-4709-3p | 4 | 0.038473 | 20 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 4 | 0.041705 | 20 |
| GO:MF | GO:0004642 | phosphoribosylformylglycinamidine synthase activity | "Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate." [EC:6.3.5.3, RHEA:17129] | 1 | 0.049992 | 20 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 5 | 0.044193 | 20 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 5 | 0.000026 | 21 |
| GO:CC | GO:0031252 | cell leading edge | "The area of a motile cell closest to the direction of movement." [GOC:pg] | 4 | 0.000157 | 21 |
| GO:CC | GO:0030056 | hemidesmosome | "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195] | 2 | 0.000189 | 21 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 5 | 0.003299 | 21 |
| GO:CC | GO:0016342 | catenin complex | "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] | 2 | 0.004183 | 21 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 3 | 0.006964 | 21 |
| GO:CC | GO:0098590 | plasma membrane region | "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] | 4 | 0.013716 | 21 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 3 | 0.016274 | 21 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 3 | 0.028433 | 21 |
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 3 | 0.029736 | 21 |
| GO:CC | GO:0030864 | cortical actin cytoskeleton | "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] | 2 | 0.031960 | 21 |
| GO:CC | GO:0001725 | stress fiber | "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] | 2 | 0.032718 | 21 |
| GO:CC | GO:0097517 | contractile actin filament bundle | "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194] | 2 | 0.032718 | 21 |
| GO:CC | GO:0016328 | lateral plasma membrane | "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] | 2 | 0.034261 | 21 |
| GO:CC | GO:0042641 | actomyosin | "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] | 2 | 0.038271 | 21 |
| GO:CC | GO:0005604 | basement membrane | "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [PMID:22505934, PMID:33605520, PMID:39223427] | 2 | 0.038271 | 21 |
| GO:CC | GO:0032432 | actin filament bundle | "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] | 2 | 0.039937 | 21 |
| GO:CC | GO:0098978 | glutamatergic synapse | "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] | 3 | 0.042432 | 21 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0045295 | gamma-catenin binding | "Binding to catenin complex gamma subunit." [GOC:bf] | 2 | 0.000651 | 21 |
| GO:MF | GO:0051010 | microtubule plus-end binding | "Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] | 2 | 0.002070 | 21 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 4 | 0.005777 | 21 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 3 | 0.041746 | 21 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0034329 | cell junction assembly | "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah] | 4 | 0.001260 | 21 |
| GO:BP | GO:0007155 | cell adhesion | "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] | 5 | 0.001609 | 21 |
| GO:BP | GO:0034330 | cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] | 4 | 0.009447 | 21 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-446728 | Cell junction organization | Cell junction organization | 3 | 0.002117 | 21 |
| REAC | REAC:R-HSA-1500931 | Cell-Cell communication | Cell-Cell communication | 3 | 0.004829 | 21 |
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 4 | 0.015386 | 21 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 4 | 0.016730 | 21 |
| REAC | REAC:R-HSA-111465 | Apoptotic cleavage of cellular proteins | Apoptotic cleavage of cellular proteins | 2 | 0.021689 | 21 |
| REAC | REAC:R-HSA-75153 | Apoptotic execution phase | Apoptotic execution phase | 2 | 0.041417 | 21 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 2 | 0.014672 | 21 |
| KEGG | KEGG:04520 | Adherens junction | Adherens junction | 2 | 0.037762 | 21 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4155 | Endometrial cancer | Endometrial cancer | 2 | 0.025605 | 21 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1904780 | negative regulation of protein localization to centrosome | "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] | 2 | 0.000036 | 22 |
| GO:BP | GO:0046604 | positive regulation of mitotic centrosome separation | "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai] | 2 | 0.000108 | 22 |
| GO:BP | GO:0046602 | regulation of mitotic centrosome separation | "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai] | 2 | 0.001292 | 22 |
| GO:BP | GO:1904779 | regulation of protein localization to centrosome | "Any process that modulates the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] | 2 | 0.002368 | 22 |
| GO:BP | GO:0006914 | autophagy | "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464] | 4 | 0.002496 | 22 |
| GO:BP | GO:0061919 | process utilizing autophagic mechanism | "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] | 4 | 0.002496 | 22 |
| GO:BP | GO:0007030 | Golgi organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] | 3 | 0.002967 | 22 |
| GO:BP | GO:0007100 | mitotic centrosome separation | "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194] | 2 | 0.003264 | 22 |
| GO:BP | GO:0051299 | centrosome separation | "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] | 2 | 0.004303 | 22 |
| GO:BP | GO:0061025 | membrane fusion | "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb] | 3 | 0.005599 | 22 |
| GO:BP | GO:0031468 | nuclear membrane reassembly | "The reformation of the nuclear membranes following their breakdown in the context of a normal process." [GOC:mah] | 2 | 0.012573 | 22 |
| GO:BP | GO:0000132 | establishment of mitotic spindle orientation | "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] | 2 | 0.023834 | 22 |
| GO:BP | GO:0071539 | protein localization to centrosome | "A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd] | 2 | 0.023834 | 22 |
| GO:BP | GO:1905508 | protein localization to microtubule organizing center | "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497] | 2 | 0.025156 | 22 |
| GO:BP | GO:0040001 | establishment of mitotic spindle localization | "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai] | 2 | 0.032297 | 22 |
| GO:BP | GO:0051294 | establishment of spindle orientation | "Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai] | 2 | 0.038648 | 22 |
| GO:BP | GO:0016236 | macroautophagy | "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339] | 3 | 0.039151 | 22 |
| GO:BP | GO:0071763 | nuclear membrane organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah] | 2 | 0.040325 | 22 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5202 | Alstrom syndrome | Alstrom syndrome | 2 | 0.006534 | 22 |
| WP | WP:WP5504 | Disorders of mitochondrial homeostatis dynamics protein import and quality control | Disorders of mitochondrial homeostatis dynamics protein import and quality control | 2 | 0.024000 | 22 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0043130 | ubiquitin binding | "Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd] | 2 | 0.048422 | 22 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5823 | MCL1-BAK1 complex | MCL1-BAK1 complex | 1 | 0.049932 | 22 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 4 | 1.196340e-07 | 23 |
| REAC | REAC:R-HSA-390466 | Chaperonin-mediated protein folding | Chaperonin-mediated protein folding | 4 | 4.314932e-06 | 23 |
| REAC | REAC:R-HSA-391251 | Protein folding | Protein folding | 4 | 5.591406e-06 | 23 |
| REAC | REAC:R-HSA-8964315 | G beta:gamma signalling through BTK | G beta:gamma signalling through BTK | 3 | 7.277611e-06 | 23 |
| REAC | REAC:R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | Prostacyclin signalling through prostacyclin receptor | 3 | 8.640983e-06 | 23 |
| REAC | REAC:R-HSA-418217 | G beta:gamma signalling through PLC beta | G beta:gamma signalling through PLC beta | 3 | 1.016448e-05 | 23 |
| REAC | REAC:R-HSA-8964616 | G beta:gamma signalling through CDC42 | G beta:gamma signalling through CDC42 | 3 | 1.016448e-05 | 23 |
| REAC | REAC:R-HSA-500657 | Presynaptic function of Kainate receptors | Presynaptic function of Kainate receptors | 3 | 1.185694e-05 | 23 |
| REAC | REAC:R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | ADP signalling through P2Y purinoceptor 12 | 3 | 1.372721e-05 | 23 |
| REAC | REAC:R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | ADP signalling through P2Y purinoceptor 1 | 3 | 1.803655e-05 | 23 |
| REAC | REAC:R-HSA-428930 | Thromboxane signalling through TP receptor | Thromboxane signalling through TP receptor | 3 | 1.803655e-05 | 23 |
| REAC | REAC:R-HSA-202040 | G-protein activation | G-protein activation | 3 | 1.803655e-05 | 23 |
| REAC | REAC:R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | G beta:gamma signalling through PI3Kgamma | 3 | 2.049328e-05 | 23 |
| REAC | REAC:R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | Adrenaline,noradrenaline inhibits insulin secretion | 3 | 2.917760e-05 | 23 |
| REAC | REAC:R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 3 | 3.253981e-05 | 23 |
| REAC | REAC:R-HSA-1296041 | Activation of G protein gated Potassium channels | Activation of G protein gated Potassium channels | 3 | 3.253981e-05 | 23 |
| REAC | REAC:R-HSA-1296059 | G protein gated Potassium channels | G protein gated Potassium channels | 3 | 3.253981e-05 | 23 |
| REAC | REAC:R-HSA-451326 | Activation of kainate receptors upon glutamate binding | Activation of kainate receptors upon glutamate binding | 3 | 3.615040e-05 | 23 |
| REAC | REAC:R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | Thrombin signalling through proteinase activated receptors (PARs) | 3 | 4.001819e-05 | 23 |
| REAC | REAC:R-HSA-392518 | Signal amplification | Signal amplification | 3 | 4.415197e-05 | 23 |
| REAC | REAC:R-HSA-397795 | G-protein beta:gamma signalling | G-protein beta:gamma signalling | 3 | 4.415197e-05 | 23 |
| REAC | REAC:R-HSA-163359 | Glucagon signaling in metabolic regulation | Glucagon signaling in metabolic regulation | 3 | 4.856054e-05 | 23 |
| REAC | REAC:R-HSA-420092 | Glucagon-type ligand receptors | Glucagon-type ligand receptors | 3 | 4.856054e-05 | 23 |
| REAC | REAC:R-HSA-1296065 | Inwardly rectifying K+ channels | Inwardly rectifying K+ channels | 3 | 5.823715e-05 | 23 |
| REAC | REAC:R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | ADORA2B mediated anti-inflammatory cytokines production | 3 | 1.020509e-04 | 23 |
| REAC | REAC:R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3 | 1.020509e-04 | 23 |
| REAC | REAC:R-HSA-977444 | GABA B receptor activation | GABA B receptor activation | 3 | 1.096897e-04 | 23 |
| REAC | REAC:R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | Vasopressin regulates renal water homeostasis via Aquaporins | 3 | 1.096897e-04 | 23 |
| REAC | REAC:R-HSA-991365 | Activation of GABAB receptors | Activation of GABAB receptors | 3 | 1.096897e-04 | 23 |
| REAC | REAC:R-HSA-9634597 | GPER1 signaling | GPER1 signaling | 3 | 1.176997e-04 | 23 |
| REAC | REAC:R-HSA-418597 | G alpha (z) signalling events | G alpha (z) signalling events | 3 | 1.536259e-04 | 23 |
| REAC | REAC:R-HSA-445717 | Aquaporin-mediated transport | Aquaporin-mediated transport | 3 | 1.961884e-04 | 23 |
| REAC | REAC:R-HSA-4086398 | Ca2+ pathway | Ca2+ pathway | 3 | 2.883160e-04 | 23 |
| REAC | REAC:R-HSA-977443 | GABA receptor activation | GABA receptor activation | 3 | 3.034490e-04 | 23 |
| REAC | REAC:R-HSA-9009391 | Extra-nuclear estrogen signaling | Extra-nuclear estrogen signaling | 3 | 5.279951e-04 | 23 |
| REAC | REAC:R-HSA-422356 | Regulation of insulin secretion | Regulation of insulin secretion | 3 | 6.729503e-04 | 23 |
| REAC | REAC:R-HSA-416482 | G alpha (12/13) signalling events | G alpha (12/13) signalling events | 3 | 7.265688e-04 | 23 |
| REAC | REAC:R-HSA-418346 | Platelet homeostasis | Platelet homeostasis | 3 | 8.728584e-04 | 23 |
| REAC | REAC:R-HSA-111885 | Opioid Signalling | Opioid Signalling | 3 | 9.693693e-04 | 23 |
| REAC | REAC:R-HSA-373080 | Class B/2 (Secretin family receptors) | Class B/2 (Secretin family receptors) | 3 | 1.145522e-03 | 23 |
| REAC | REAC:R-HSA-1296071 | Potassium Channels | Potassium Channels | 3 | 1.559029e-03 | 23 |
| REAC | REAC:R-HSA-163685 | Integration of energy metabolism | Integration of energy metabolism | 3 | 1.748783e-03 | 23 |
| REAC | REAC:R-HSA-9664433 | Leishmania parasite growth and survival | Leishmania parasite growth and survival | 3 | 3.215359e-03 | 23 |
| REAC | REAC:R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | Anti-inflammatory response favouring Leishmania parasite infection | 3 | 3.215359e-03 | 23 |
| REAC | REAC:R-HSA-3858494 | Beta-catenin independent WNT signaling | Beta-catenin independent WNT signaling | 3 | 4.183617e-03 | 23 |
| REAC | REAC:R-HSA-418555 | G alpha (s) signalling events | G alpha (s) signalling events | 3 | 5.431356e-03 | 23 |
| REAC | REAC:R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | Neurotransmitter receptors and postsynaptic signal transmission | 3 | 1.059229e-02 | 23 |
| REAC | REAC:R-HSA-416476 | G alpha (q) signalling events | G alpha (q) signalling events | 3 | 1.359609e-02 | 23 |
| REAC | REAC:R-HSA-9824443 | Parasitic Infection Pathways | Parasitic Infection Pathways | 3 | 1.398253e-02 | 23 |
| REAC | REAC:R-HSA-9658195 | Leishmania infection | Leishmania infection | 3 | 1.398253e-02 | 23 |
| REAC | REAC:R-HSA-8939211 | ESR-mediated signaling | ESR-mediated signaling | 3 | 1.417843e-02 | 23 |
| REAC | REAC:R-HSA-112315 | Transmission across Chemical Synapses | Transmission across Chemical Synapses | 3 | 2.441206e-02 | 23 |
| REAC | REAC:R-HSA-76002 | Platelet activation, signaling and aggregation | Platelet activation, signaling and aggregation | 3 | 2.469471e-02 | 23 |
| REAC | REAC:R-HSA-9006931 | Signaling by Nuclear Receptors | Signaling by Nuclear Receptors | 3 | 3.420708e-02 | 23 |
| REAC | REAC:R-HSA-418594 | G alpha (i) signalling events | G alpha (i) signalling events | 3 | 4.253010e-02 | 23 |
| REAC | REAC:R-HSA-195721 | Signaling by WNT | Signaling by WNT | 3 | 4.935119e-02 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005834 | heterotrimeric G-protein complex | "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684] | 3 | 0.000009 | 23 |
| GO:CC | GO:1905360 | GTPase complex | "A protein complex which is capable of GTPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9178006] | 3 | 0.000014 | 23 |
| GO:CC | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane | "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] | 3 | 0.000029 | 23 |
| GO:CC | GO:0019897 | extrinsic component of plasma membrane | "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] | 3 | 0.000284 | 23 |
| GO:CC | GO:0009898 | cytoplasmic side of plasma membrane | "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] | 3 | 0.000888 | 23 |
| GO:CC | GO:0019898 | extrinsic component of membrane | "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] | 3 | 0.001357 | 23 |
| GO:CC | GO:0098562 | cytoplasmic side of membrane | "The side of a membrane that faces the cytoplasm." [GOC:dos] | 3 | 0.001833 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7087 | GNAI1-GNB2-GNG12 complex | GNAI1-GNB2-GNG12 complex | 2 | 0.000132 | 23 |
| CORUM | CORUM:7205 | GNAS-L-GNB2-GNG12 complex | GNAS-L-GNB2-GNG12 complex | 2 | 0.000132 | 23 |
| CORUM | CORUM:7204 | GNAS-L-GNB1-GNG12 complex | GNAS-L-GNB1-GNG12 complex | 2 | 0.000132 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04727 | GABAergic synapse | GABAergic synapse | 3 | 0.000238 | 23 |
| KEGG | KEGG:05032 | Morphine addiction | Morphine addiction | 3 | 0.000238 | 23 |
| KEGG | KEGG:04713 | Circadian entrainment | Circadian entrainment | 3 | 0.000309 | 23 |
| KEGG | KEGG:04726 | Serotonergic synapse | Serotonergic synapse | 3 | 0.000477 | 23 |
| KEGG | KEGG:04725 | Cholinergic synapse | Cholinergic synapse | 3 | 0.000490 | 23 |
| KEGG | KEGG:04724 | Glutamatergic synapse | Glutamatergic synapse | 3 | 0.000516 | 23 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | Relaxin signaling pathway | 3 | 0.000730 | 23 |
| KEGG | KEGG:04728 | Dopaminergic synapse | Dopaminergic synapse | 3 | 0.000764 | 23 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 4 | 0.000791 | 23 |
| KEGG | KEGG:04371 | Apelin signaling pathway | Apelin signaling pathway | 3 | 0.000894 | 23 |
| KEGG | KEGG:04723 | Retrograde endocannabinoid signaling | Retrograde endocannabinoid signaling | 3 | 0.001103 | 23 |
| KEGG | KEGG:05034 | Alcoholism | Alcoholism | 3 | 0.002228 | 23 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | Chemokine signaling pathway | 3 | 0.002336 | 23 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 3 | 0.002487 | 23 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | Human immunodeficiency virus 1 infection | 3 | 0.003154 | 23 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 3 | 0.003775 | 23 |
| KEGG | KEGG:04014 | Ras signaling pathway | Ras signaling pathway | 3 | 0.004416 | 23 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 3 | 0.015252 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP35 | G protein signaling | G protein signaling | 3 | 0.000341 | 23 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 4 | 0.000926 | 23 |
| WP | WP:WP536 | Calcium regulation in cardiac cells | Calcium regulation in cardiac cells | 3 | 0.001647 | 23 |
| WP | WP:WP289 | Myometrial relaxation and contraction pathways | Myometrial relaxation and contraction pathways | 3 | 0.001782 | 23 |
| WP | WP:WP3929 | Chemokine signaling | Chemokine signaling | 3 | 0.002193 | 23 |
| WP | WP:WP4223 | Ras signaling | Ras signaling | 3 | 0.002992 | 23 |
| WP | WP:WP3932 | Focal adhesion PI3K Akt mTOR signaling | Focal adhesion PI3K Akt mTOR signaling | 3 | 0.013395 | 23 |
| WP | WP:WP4172 | PI3K Akt signaling | PI3K Akt signaling | 3 | 0.018411 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0030159 | signaling receptor complex adaptor activity | "The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah] | 2 | 0.012043 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-5692a | hsa-mir-5692a | hsa-mir-5692a | 3 | 0.01604 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0210863 | Fallopian tube; ciliated cells (cilia axoneme)[High] | Fallopian tube; ciliated cells (cilia axoneme)[High] | 2 | 0.040154 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 5 | 0.049511 | 24 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 4 | 0.000311 | 25 |
| GO:CC | GO:1990204 | oxidoreductase complex | "Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432] | 3 | 0.000628 | 25 |
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 5 | 0.000881 | 25 |
| GO:CC | GO:0030964 | NADH dehydrogenase complex | "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone." [GOC:mah] | 2 | 0.008895 | 25 |
| GO:CC | GO:0045271 | respiratory chain complex I | "Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex." [GOC:imk, GOC:jid, ISBN:0716749556] | 2 | 0.008895 | 25 |
| GO:CC | GO:0005743 | mitochondrial inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] | 3 | 0.026549 | 25 |
| GO:CC | GO:0019866 | organelle inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] | 3 | 0.036276 | 25 |
| GO:CC | GO:0098803 | respiratory chain complex | "Any protein complex that is part of a respiratory chain." [GOC:dos] | 2 | 0.046043 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-611105 | Respiratory electron transport | Respiratory electron transport | 3 | 0.000691 | 25 |
| REAC | REAC:R-HSA-1428517 | Aerobic respiration and respiratory electron transport | Aerobic respiration and respiratory electron transport | 3 | 0.004516 | 25 |
| REAC | REAC:R-HSA-6799198 | Complex I biogenesis | Complex I biogenesis | 2 | 0.026632 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2948 | Respiratory chain complex I (incomplete intermediate), mitochondrial | Respiratory chain complex I (incomplete intermediate), mitochondrial | 2 | 0.001623 | 25 |
| CORUM | CORUM:178 | Respiratory chain complex I (holoenzyme), mitochondrial | Respiratory chain complex I (holoenzyme), mitochondrial | 2 | 0.027733 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016491 | oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-] | 4 | 0.001925 | 25 |
| GO:MF | GO:0008137 | NADH dehydrogenase (ubiquinone) activity | "Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out)." [RHEA:29091] | 2 | 0.008068 | 25 |
| GO:MF | GO:0003954 | NADH dehydrogenase activity | "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [RHEA:11356] | 2 | 0.009305 | 25 |
| GO:MF | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] | 2 | 0.016237 | 25 |
| GO:MF | GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-] | 2 | 0.021054 | 25 |
| GO:MF | GO:0016651 | oxidoreductase activity, acting on NAD(P)H | "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] | 2 | 0.043699 | 25 |
| GO:MF | GO:0046554 | L-malate dehydrogenase (NADP+) activity | "Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+." [RHEA:10824] | 1 | 0.049992 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0009060 | aerobic respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] | 3 | 0.002212 | 25 |
| GO:BP | GO:0045333 | cellular respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] | 3 | 0.003982 | 25 |
| GO:BP | GO:0019637 | organophosphate metabolic process | "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] | 4 | 0.004565 | 25 |
| GO:BP | GO:0015980 | energy derivation by oxidation of organic compounds | "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] | 3 | 0.011537 | 25 |
| GO:BP | GO:0006163 | purine nucleotide metabolic process | "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 3 | 0.022308 | 25 |
| GO:BP | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363] | 2 | 0.023002 | 25 |
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] | 3 | 0.030612 | 25 |
| GO:BP | GO:0009117 | nucleotide metabolic process | "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] | 3 | 0.033573 | 25 |
| GO:BP | GO:0044281 | small molecule metabolic process | "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] | 4 | 0.033831 | 25 |
| GO:BP | GO:0010257 | NADH dehydrogenase complex assembly | "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex." [GOC:sm] | 2 | 0.035206 | 25 |
| GO:BP | GO:0032981 | mitochondrial respiratory chain complex I assembly | "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph] | 2 | 0.035206 | 25 |
| GO:BP | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis | "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force)." [GOC:vw] | 2 | 0.039847 | 25 |
| GO:BP | GO:0072521 | purine-containing compound metabolic process | "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 3 | 0.049912 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP623 | Oxidative phosphorylation | Oxidative phosphorylation | 2 | 0.023216 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005789 | endoplasmic reticulum membrane | "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] | 4 | 0.010105 | 26 |
| GO:CC | GO:0098827 | endoplasmic reticulum subcompartment | "A distinct region of the endoplasmic reticulum." [GOC:dos] | 4 | 0.010301 | 26 |
| GO:CC | GO:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network | "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] | 4 | 0.010941 | 26 |
| GO:CC | GO:0031984 | organelle subcompartment | "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] | 4 | 0.025729 | 26 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00483 | Factor: ATF6; motif: TGACGTGG | Factor: ATF6; motif: TGACGTGG | 5 | 0.039496 | 26 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2 | 0.002094 | 27 |
| REAC | REAC:R-HSA-1980145 | Signaling by NOTCH2 | Signaling by NOTCH2 | 2 | 0.004494 | 27 |
| REAC | REAC:R-HSA-9013694 | Signaling by NOTCH4 | Signaling by NOTCH4 | 2 | 0.029266 | 27 |
| REAC | REAC:R-HSA-192823 | Viral mRNA Translation | Viral mRNA Translation | 2 | 0.036156 | 27 |
| REAC | REAC:R-HSA-156902 | Peptide chain elongation | Peptide chain elongation | 2 | 0.036156 | 27 |
| REAC | REAC:R-HSA-2408557 | Selenocysteine synthesis | Selenocysteine synthesis | 2 | 0.039450 | 27 |
| REAC | REAC:R-HSA-72764 | Eukaryotic Translation Termination | Eukaryotic Translation Termination | 2 | 0.039450 | 27 |
| REAC | REAC:R-HSA-156842 | Eukaryotic Translation Elongation | Eukaryotic Translation Elongation | 2 | 0.039450 | 27 |
| REAC | REAC:R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2 | 0.041151 | 27 |
| REAC | REAC:R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2 | 0.046467 | 27 |
| REAC | REAC:R-HSA-72689 | Formation of a pool of free 40S subunits | Formation of a pool of free 40S subunits | 2 | 0.046467 | 27 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0022626 | cytosolic ribosome | "A ribosome located in the cytosol." [GOC:mtg_sensu] | 2 | 0.021997 | 27 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05544 | Factor: BCL-11A; motif: CSTAMGGA | Factor: BCL-11A; motif: CSTAMGGA | 3 | 0.025399 | 27 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03010 | Ribosome | Ribosome | 2 | 0.047421 | 27 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008424 | Hypoplastic 5th lumbar vertebrae | Hypoplastic 5th lumbar vertebrae | 1 | 0.049962 | 27 |
| HP | HP:0005463 | Elongated sella turcica | Elongated sella turcica | 1 | 0.049962 | 27 |
| HP | HP:0006180 | Crowded carpal bones | Crowded carpal bones | 1 | 0.049962 | 27 |
| HP | HP:0008421 | Tall lumbar vertebral bodies | Tall lumbar vertebral bodies | 1 | 0.049962 | 27 |
| HP | HP:0011305 | Partial absence of toe | The absence of a phalangeal segment of a toe or hallux. | 1 | 0.049962 | 27 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3159 | RIAM-profilin complex | RIAM-profilin complex | 1 | 0.049932 | 28 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity | "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [GOC:mah] | 3 | 6.939812e-08 | 29 |
| GO:MF | GO:0033192 | calmodulin-dependent protein phosphatase activity | "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118] | 2 | 4.911737e-05 | 29 |
| GO:MF | GO:0004722 | protein serine/threonine phosphatase activity | "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf] | 3 | 9.091153e-05 | 29 |
| GO:MF | GO:0004721 | phosphoprotein phosphatase activity | "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684] | 3 | 8.502604e-04 | 29 |
| GO:MF | GO:0016791 | phosphatase activity | "Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate." [GOC:curators, GOC:pg] | 3 | 2.344015e-03 | 29 |
| GO:MF | GO:0042578 | phosphoric ester hydrolase activity | "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl] | 3 | 4.671060e-03 | 29 |
| GO:MF | GO:0017018 | myosin phosphatase activity | "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16] | 2 | 1.875073e-02 | 29 |
| GO:MF | GO:0016788 | hydrolase activity, acting on ester bonds | "Catalysis of the hydrolysis of any ester bond." [GOC:jl] | 3 | 3.118444e-02 | 29 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5501 | GNAQ p R183Q drives capillary malformation | GNAQ p R183Q drives capillary malformation | 3 | 0.000001 | 29 |
| WP | WP:WP5142 | Calcium mediated T cell apoptosis involved in inclusion body myositis | Calcium mediated T cell apoptosis involved in inclusion body myositis | 2 | 0.000970 | 29 |
| WP | WP:WP3414 | Initiation of transcription and translation elongation at the HIV 1 LTR | Initiation of transcription and translation elongation at the HIV 1 LTR | 2 | 0.002531 | 29 |
| WP | WP:WP2447 | Amyotrophic lateral sclerosis ALS | Amyotrophic lateral sclerosis ALS | 2 | 0.003585 | 29 |
| WP | WP:WP1541 | Energy metabolism | Energy metabolism | 2 | 0.005509 | 29 |
| WP | WP:WP35 | G protein signaling | G protein signaling | 2 | 0.019892 | 29 |
| WP | WP:WP1544 | MicroRNAs in cardiomyocyte hypertrophy | MicroRNAs in cardiomyocyte hypertrophy | 2 | 0.027176 | 29 |
| WP | WP:WP428 | Wnt signaling | Wnt signaling | 2 | 0.032085 | 29 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0070884 | regulation of calcineurin-NFAT signaling cascade | "Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:ai] | 3 | 0.000003 | 29 |
| GO:BP | GO:0106056 | regulation of calcineurin-mediated signaling | "Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204] | 3 | 0.000003 | 29 |
| GO:BP | GO:0033173 | calcineurin-NFAT signaling cascade | "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+)." [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679] | 3 | 0.000005 | 29 |
| GO:BP | GO:0097720 | calcineurin-mediated signaling | "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544] | 3 | 0.000006 | 29 |
| GO:BP | GO:0050848 | regulation of calcium-mediated signaling | "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai] | 3 | 0.000051 | 29 |
| GO:BP | GO:1905949 | negative regulation of calcium ion import across plasma membrane | "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] | 2 | 0.000068 | 29 |
| GO:BP | GO:1905665 | positive regulation of calcium ion import across plasma membrane | "Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] | 2 | 0.000244 | 29 |
| GO:BP | GO:1905664 | regulation of calcium ion import across plasma membrane | "Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] | 2 | 0.000448 | 29 |
| GO:BP | GO:0019722 | calcium-mediated signaling | "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling] | 3 | 0.000680 | 29 |
| GO:BP | GO:0090281 | negative regulation of calcium ion import | "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] | 2 | 0.000712 | 29 |
| GO:BP | GO:0106058 | positive regulation of calcineurin-mediated signaling | "Any process that activates or increases the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204] | 2 | 0.001289 | 29 |
| GO:BP | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade | "Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade." [GOC:mah] | 2 | 0.001289 | 29 |
| GO:BP | GO:0090280 | positive regulation of calcium ion import | "Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] | 2 | 0.002034 | 29 |
| GO:BP | GO:0098703 | calcium ion import across plasma membrane | "The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] | 2 | 0.004515 | 29 |
| GO:BP | GO:1902656 | calcium ion import into cytosol | "The directed movement of calcium ion into a cytosol." [GO_REF:0000075, GOC:TermGenie, GOC:vw] | 2 | 0.004765 | 29 |
| GO:BP | GO:0048741 | skeletal muscle fiber development | "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle] | 2 | 0.005558 | 29 |
| GO:BP | GO:1903170 | negative regulation of calcium ion transmembrane transport | "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847] | 2 | 0.006411 | 29 |
| GO:BP | GO:0090279 | regulation of calcium ion import | "Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] | 2 | 0.007014 | 29 |
| GO:BP | GO:0014904 | myotube cell development | "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] | 2 | 0.007014 | 29 |
| GO:BP | GO:0050850 | positive regulation of calcium-mediated signaling | "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling." [GOC:ai] | 2 | 0.011590 | 29 |
| GO:BP | GO:0051926 | negative regulation of calcium ion transport | "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 2 | 0.011990 | 29 |
| GO:BP | GO:1904063 | negative regulation of cation transmembrane transport | "Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] | 2 | 0.019295 | 29 |
| GO:BP | GO:1904427 | positive regulation of calcium ion transmembrane transport | "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:22910094] | 2 | 0.021391 | 29 |
| GO:BP | GO:0070509 | calcium ion import | "The directed movement of calcium ions into a cell or organelle." [GOC:mah] | 2 | 0.022480 | 29 |
| GO:BP | GO:0034766 | negative regulation of monoatomic ion transmembrane transport | "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] | 2 | 0.023595 | 29 |
| GO:BP | GO:0043271 | negative regulation of monoatomic ion transport | "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] | 2 | 0.042792 | 29 |
| GO:BP | GO:0034763 | negative regulation of transmembrane transport | "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] | 2 | 0.043555 | 29 |
| GO:BP | GO:0051928 | positive regulation of calcium ion transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 2 | 0.045101 | 29 |
| GO:BP | GO:0099587 | inorganic ion import across plasma membrane | "The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] | 2 | 0.045883 | 29 |
| GO:BP | GO:0098659 | inorganic cation import across plasma membrane | "The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] | 2 | 0.045883 | 29 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2266 | PPP3CA-PPP3CA-RCAN1 complex | PPP3CA-PPP3CA-RCAN1 complex | 2 | 0.000015 | 29 |
| CORUM | CORUM:517 | AKAP5-PRKAR2A-PPP3CA complex | AKAP5-PRKAR2A-PPP3CA complex | 1 | 0.049932 | 29 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005955 | calcineurin complex | "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [PMID:26794871] | 2 | 0.000034 | 29 |
| GO:CC | GO:1903293 | phosphatase complex | "A protein complex which is capable of phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807] | 2 | 0.003470 | 29 |
| GO:CC | GO:0008287 | protein serine/threonine phosphatase complex | "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf] | 2 | 0.003470 | 29 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04921 | Oxytocin signaling pathway | Oxytocin signaling pathway | 3 | 0.000290 | 29 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 3 | 0.000583 | 29 |
| KEGG | KEGG:04370 | VEGF signaling pathway | VEGF signaling pathway | 2 | 0.007030 | 29 |
| KEGG | KEGG:04720 | Long-term potentiation | Long-term potentiation | 2 | 0.009078 | 29 |
| KEGG | KEGG:04924 | Renin secretion | Renin secretion | 2 | 0.009631 | 29 |
| KEGG | KEGG:05031 | Amphetamine addiction | Amphetamine addiction | 2 | 0.009631 | 29 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | B cell receptor signaling pathway | 2 | 0.013289 | 29 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | PD-L1 expression and PD-1 checkpoint pathway in cancer | 2 | 0.016051 | 29 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | Th1 and Th2 cell differentiation | 2 | 0.016051 | 29 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | C-type lectin receptor signaling pathway | 2 | 0.021928 | 29 |
| KEGG | KEGG:04659 | Th17 cell differentiation | Th17 cell differentiation | 2 | 0.022352 | 29 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | Glucagon signaling pathway | 2 | 0.023212 | 29 |
| KEGG | KEGG:04724 | Glutamatergic synapse | Glutamatergic synapse | 2 | 0.026813 | 29 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | T cell receptor signaling pathway | 2 | 0.028710 | 29 |
| KEGG | KEGG:04650 | Natural killer cell mediated cytotoxicity | Natural killer cell mediated cytotoxicity | 2 | 0.031172 | 29 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 2 | 0.034786 | 29 |
| KEGG | KEGG:04728 | Dopaminergic synapse | Dopaminergic synapse | 2 | 0.034786 | 29 |
| KEGG | KEGG:04380 | Osteoclast differentiation | Osteoclast differentiation | 2 | 0.035319 | 29 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 2 | 0.048665 | 29 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-180024 | DARPP-32 events | DARPP-32 events | 2 | 0.001148 | 29 |
| REAC | REAC:R-HSA-111885 | Opioid Signalling | Opioid Signalling | 2 | 0.017372 | 29 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0091063 | Cerebellum; synaptic glomeruli - core[High] | Cerebellum; synaptic glomeruli - core[High] | 2 | 0.023338 | 29 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05988 | Factor: ZNF860; motif: NTGGGAAAWGSM | Factor: ZNF860; motif: NTGGGAAAWGSM | 2 | 0.020915 | 30 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004617 | phosphoglycerate dehydrogenase activity | "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] | 1 | 0.049891 | 30 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0007525 | Yellow subcutaneous tissue covered by thin, scaly skin | Yellow subcutaneous tissue covered by thin, scaly skin | 1 | 0.049962 | 30 |
| HP | HP:0034691 | Reduced 3-phosphoglycerate dehydrogenase activity | Diminished activity of the enzyme 3-phosphoglycerate dehydrogenase (PGDH), which catalyzes the first step in the pathway by converting D-3-phosphoglycerate (PGA), an intermediate in glycolysis, to phosphohydroxypyruvate concomitant with the reduction of NAD+. | 1 | 0.049962 | 30 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-637 | hsa-mir-637 | hsa-mir-637 | 4 | 0.019603 | 31 |
| MIRNA | MIRNA:hsa-mir-548aa | hsa-mir-548aa | hsa-mir-548aa | 4 | 0.041974 | 31 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004521 | RNA endonuclease activity | "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] | 2 | 0.022663 | 31 |
| GO:MF | GO:0016894 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters | "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah] | 1 | 0.049891 | 31 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 3 | 0.042861 | 31 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0003568 | Decreased glucosephosphate isomerase level | A decreased level of glucose-6-phosphate isomerase. | 1 | 0.049962 | 31 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 4 | 0.023013 | 32 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 4 | 0.027372 | 32 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0042220 | response to cocaine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:ef, GOC:jl] | 2 | 0.029808 | 32 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 2 | 0.048656 | 32 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05221 | Acute myeloid leukemia | Acute myeloid leukemia | 3 | 0.000023 | 34 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 3 | 0.000038 | 34 |
| KEGG | KEGG:04012 | ErbB signaling pathway | ErbB signaling pathway | 3 | 0.000046 | 34 |
| KEGG | KEGG:04211 | Longevity regulating pathway | Longevity regulating pathway | 3 | 0.000055 | 34 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | Choline metabolism in cancer | 3 | 0.000074 | 34 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | HIF-1 signaling pathway | 3 | 0.000102 | 34 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 3 | 0.000137 | 34 |
| KEGG | KEGG:04910 | Insulin signaling pathway | Insulin signaling pathway | 3 | 0.000204 | 34 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 3 | 0.000296 | 34 |
| KEGG | KEGG:04150 | mTOR signaling pathway | mTOR signaling pathway | 3 | 0.000296 | 34 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | Chemical carcinogenesis - receptor activation | 3 | 0.000751 | 34 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 3 | 0.000887 | 34 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 3 | 0.002888 | 34 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 3 | 0.003628 | 34 |
| KEGG | KEGG:04973 | Carbohydrate digestion and absorption | Carbohydrate digestion and absorption | 2 | 0.004446 | 34 |
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 2 | 0.006792 | 34 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | Regulation of lipolysis in adipocytes | 2 | 0.006792 | 34 |
| KEGG | KEGG:04370 | VEGF signaling pathway | VEGF signaling pathway | 2 | 0.007030 | 34 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | Longevity regulating pathway - multiple species | 2 | 0.007518 | 34 |
| KEGG | KEGG:04929 | GnRH secretion | GnRH secretion | 2 | 0.008280 | 34 |
| KEGG | KEGG:04664 | Fc epsilon RI signaling pathway | Fc epsilon RI signaling pathway | 2 | 0.009078 | 34 |
| KEGG | KEGG:05211 | Renal cell carcinoma | Renal cell carcinoma | 2 | 0.009353 | 34 |
| KEGG | KEGG:04917 | Prolactin signaling pathway | Prolactin signaling pathway | 2 | 0.009914 | 34 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | Central carbon metabolism in cancer | 2 | 0.009914 | 34 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | Adipocytokine signaling pathway | 2 | 0.009914 | 34 |
| KEGG | KEGG:05168 | Herpes simplex virus 1 infection | Herpes simplex virus 1 infection | 3 | 0.010444 | 34 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 2 | 0.010491 | 34 |
| KEGG | KEGG:05218 | Melanoma | Melanoma | 2 | 0.010491 | 34 |
| KEGG | KEGG:01524 | Platinum drug resistance | Platinum drug resistance | 2 | 0.010491 | 34 |
| KEGG | KEGG:05214 | Glioma | Glioma | 2 | 0.011387 | 34 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 2 | 0.011694 | 34 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 2 | 0.011694 | 34 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | B cell receptor signaling pathway | 2 | 0.013289 | 34 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 2 | 0.014985 | 34 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | PD-L1 expression and PD-1 checkpoint pathway in cancer | 2 | 0.016051 | 34 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 2 | 0.017154 | 34 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 2 | 0.018293 | 34 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | Fc gamma R-mediated phagocytosis | 2 | 0.018681 | 34 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 2 | 0.019073 | 34 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | AGE-RAGE signaling pathway in diabetic complications | 2 | 0.020272 | 34 |
| KEGG | KEGG:05142 | Chagas disease | Chagas disease | 2 | 0.020680 | 34 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | Progesterone-mediated oocyte maturation | 2 | 0.021092 | 34 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | C-type lectin receptor signaling pathway | 2 | 0.021928 | 34 |
| KEGG | KEGG:04620 | Toll-like receptor signaling pathway | Toll-like receptor signaling pathway | 2 | 0.022780 | 34 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | Glucagon signaling pathway | 2 | 0.023212 | 34 |
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 2 | 0.023648 | 34 |
| KEGG | KEGG:05145 | Toxoplasmosis | Toxoplasmosis | 2 | 0.023648 | 34 |
| KEGG | KEGG:04668 | TNF signaling pathway | TNF signaling pathway | 2 | 0.025889 | 34 |
| KEGG | KEGG:04725 | Cholinergic synapse | Cholinergic synapse | 2 | 0.025889 | 34 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | Neurotrophin signaling pathway | 2 | 0.028230 | 34 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | T cell receptor signaling pathway | 2 | 0.028710 | 34 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | Sphingolipid signaling pathway | 2 | 0.029195 | 34 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | Growth hormone synthesis, secretion and action | 2 | 0.029195 | 34 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | Thyroid hormone signaling pathway | 2 | 0.029683 | 34 |
| KEGG | KEGG:04611 | Platelet activation | Platelet activation | 2 | 0.031172 | 34 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | Relaxin signaling pathway | 2 | 0.033734 | 34 |
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 2 | 0.034786 | 34 |
| KEGG | KEGG:04728 | Dopaminergic synapse | Dopaminergic synapse | 2 | 0.034786 | 34 |
| KEGG | KEGG:04380 | Osteoclast differentiation | Osteoclast differentiation | 2 | 0.035319 | 34 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 2 | 0.036940 | 34 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | Estrogen signaling pathway | 2 | 0.037488 | 34 |
| KEGG | KEGG:05135 | Yersinia infection | Yersinia infection | 2 | 0.037488 | 34 |
| KEGG | KEGG:05162 | Measles | Measles | 2 | 0.038597 | 34 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | Fluid shear stress and atherosclerosis | 2 | 0.038597 | 34 |
| KEGG | KEGG:04371 | Apelin signaling pathway | Apelin signaling pathway | 2 | 0.038597 | 34 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | Spinocerebellar ataxia | 2 | 0.040290 | 34 |
| KEGG | KEGG:04936 | Alcoholic liver disease | Alcoholic liver disease | 2 | 0.040862 | 34 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | Signaling pathways regulating pluripotency of stem cells | 2 | 0.041439 | 34 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | Phospholipase D signaling pathway | 2 | 0.043784 | 34 |
| KEGG | KEGG:05224 | Breast cancer | Breast cancer | 2 | 0.043784 | 34 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 2 | 0.044380 | 34 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | Adrenergic signaling in cardiomyocytes | 2 | 0.047421 | 34 |
| KEGG | KEGG:04932 | Non-alcoholic fatty liver disease | Non-alcoholic fatty liver disease | 2 | 0.048041 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5215 | Targeted agents in triple negative breast cancer | Targeted agents in triple negative breast cancer | 3 | 0.000025 | 34 |
| WP | WP:WP4566 | Translation inhibitors in chronically activated PDGFRA cells | Translation inhibitors in chronically activated PDGFRA cells | 3 | 0.000046 | 34 |
| WP | WP:WP4539 | Synaptic signaling associated with autism spectrum disorder | Synaptic signaling associated with autism spectrum disorder | 3 | 0.000059 | 34 |
| WP | WP:WP5441 | Artemisinin inhibition of uveal melanoma | Artemisinin inhibition of uveal melanoma | 2 | 0.000079 | 34 |
| WP | WP:WP5293 | Acute myeloid leukemia | Acute myeloid leukemia | 3 | 0.000151 | 34 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 3 | 0.000195 | 34 |
| WP | WP:WP4806 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 3 | 0.000286 | 34 |
| WP | WP:WP673 | ErbB signaling | ErbB signaling | 3 | 0.000341 | 34 |
| WP | WP:WP5470 | Effect of omega 3 PUFA on Huntington 39 s disease pathways | Effect of omega 3 PUFA on Huntington 39 s disease pathways | 3 | 0.000841 | 34 |
| WP | WP:WP3873 | RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis | RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis | 2 | 0.001387 | 34 |
| WP | WP:WP5372 | Involvement of secretase in neurodegenerative diseases | Involvement of secretase in neurodegenerative diseases | 2 | 0.001796 | 34 |
| WP | WP:WP3859 | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | 2 | 0.002257 | 34 |
| WP | WP:WP5294 | Sildenafil treatment | Sildenafil treatment | 2 | 0.003048 | 34 |
| WP | WP:WP3872 | Apoptosis regulation by parathyroid hormone related protein | Apoptosis regulation by parathyroid hormone related protein | 2 | 0.003640 | 34 |
| WP | WP:WP26 | S1P receptor signal transduction | S1P receptor signal transduction | 2 | 0.003956 | 34 |
| WP | WP:WP4483 | Relationship between inflammation COX 2 and EGFR | Relationship between inflammation COX 2 and EGFR | 2 | 0.003956 | 34 |
| WP | WP:WP5385 | Growth factors and hormones in beta cell proliferation | Growth factors and hormones in beta cell proliferation | 2 | 0.004285 | 34 |
| WP | WP:WP5494 | Tyrosine kinase inhibitors in glioblastoma | Tyrosine kinase inhibitors in glioblastoma | 2 | 0.004285 | 34 |
| WP | WP:WP5496 | Targeted therapy in breast cancer | Targeted therapy in breast cancer | 2 | 0.004285 | 34 |
| WP | WP:WP3965 | Lipid metabolism pathway | Lipid metabolism pathway | 2 | 0.005351 | 34 |
| WP | WP:WP5490 | Inhibition of GNAQ regulated signaling in uveal melanoma | Inhibition of GNAQ regulated signaling in uveal melanoma | 2 | 0.006954 | 34 |
| WP | WP:WP4481 | Resistin as a regulator of inflammation | Resistin as a regulator of inflammation | 2 | 0.006954 | 34 |
| WP | WP:WP5531 | AKT signaling and ARTD family members | AKT signaling and ARTD family members | 2 | 0.007388 | 34 |
| WP | WP:WP5358 | JAK STAT signaling in the regulation of beta cells | JAK STAT signaling in the regulation of beta cells | 2 | 0.007388 | 34 |
| WP | WP:WP5497 | Cyclin dependent kinase 4 6 inhibitors in breast cancer | Cyclin dependent kinase 4 6 inhibitors in breast cancer | 2 | 0.009252 | 34 |
| WP | WP:WP4564 | Neural crest cell migration during development | Neural crest cell migration during development | 2 | 0.009751 | 34 |
| WP | WP:WP4565 | Neural crest cell migration in cancer | Neural crest cell migration in cancer | 2 | 0.011324 | 34 |
| WP | WP:WP5493 | Effect of dasatinib on the BCR ABL signaling pathway | Effect of dasatinib on the BCR ABL signaling pathway | 2 | 0.013015 | 34 |
| WP | WP:WP3932 | Focal adhesion PI3K Akt mTOR signaling | Focal adhesion PI3K Akt mTOR signaling | 3 | 0.013395 | 34 |
| WP | WP:WP5373 | Osteoarthritic chondrocyte hypertrophy | Osteoarthritic chondrocyte hypertrophy | 2 | 0.016092 | 34 |
| WP | WP:WP5144 | NRP1 triggered signaling in pancreatic cancer | NRP1 triggered signaling in pancreatic cancer | 2 | 0.018094 | 34 |
| WP | WP:WP4172 | PI3K Akt signaling | PI3K Akt signaling | 3 | 0.018411 | 34 |
| WP | WP:WP4205 | MET in type 1 papillary renal cell carcinoma | MET in type 1 papillary renal cell carcinoma | 2 | 0.021688 | 34 |
| WP | WP:WP4155 | Endometrial cancer | Endometrial cancer | 2 | 0.025605 | 34 |
| WP | WP:WP1403 | AMP activated protein kinase signaling | AMP activated protein kinase signaling | 2 | 0.028970 | 34 |
| WP | WP:WP4685 | Melanoma | Melanoma | 2 | 0.029843 | 34 |
| WP | WP:WP4255 | Non small cell lung cancer | Non small cell lung cancer | 2 | 0.033464 | 34 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 2 | 0.034402 | 34 |
| WP | WP:WP5087 | Pleural mesothelioma | Pleural mesothelioma | 3 | 0.039684 | 34 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 2 | 0.043413 | 34 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 2 | 0.049995 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-211163 | AKT-mediated inactivation of FOXO1A | AKT-mediated inactivation of FOXO1A | 2 | 0.000054 | 34 |
| REAC | REAC:R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | RUNX2 regulates genes involved in cell migration | 2 | 0.000191 | 34 |
| REAC | REAC:R-HSA-198693 | AKT phosphorylates targets in the nucleus | AKT phosphorylates targets in the nucleus | 2 | 0.000327 | 34 |
| REAC | REAC:R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2 | 0.000599 | 34 |
| REAC | REAC:R-HSA-9614399 | Regulation of localization of FOXO transcription factors | Regulation of localization of FOXO transcription factors | 2 | 0.000599 | 34 |
| REAC | REAC:R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | Downregulation of ERBB2:ERBB3 signaling | 2 | 0.000599 | 34 |
| REAC | REAC:R-HSA-198323 | AKT phosphorylates targets in the cytosol | AKT phosphorylates targets in the cytosol | 2 | 0.000825 | 34 |
| REAC | REAC:R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | Regulation of TP53 Activity through Association with Co-factors | 2 | 0.000825 | 34 |
| REAC | REAC:R-HSA-111447 | Activation of BAD and translocation to mitochondria | Activation of BAD and translocation to mitochondria | 2 | 0.000952 | 34 |
| REAC | REAC:R-HSA-210745 | Regulation of gene expression in beta cells | Regulation of gene expression in beta cells | 2 | 0.001550 | 34 |
| REAC | REAC:R-HSA-389513 | Co-inhibition by CTLA4 | Co-inhibition by CTLA4 | 2 | 0.001723 | 34 |
| REAC | REAC:R-HSA-389357 | CD28 dependent PI3K/Akt signaling | CD28 dependent PI3K/Akt signaling | 2 | 0.002094 | 34 |
| REAC | REAC:R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2 | 0.002293 | 34 |
| REAC | REAC:R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | G beta:gamma signalling through PI3Kgamma | 2 | 0.002719 | 34 |
| REAC | REAC:R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | Constitutive Signaling by AKT1 E17K in Cancer | 2 | 0.002719 | 34 |
| REAC | REAC:R-HSA-8863795 | Downregulation of ERBB2 signaling | Downregulation of ERBB2 signaling | 2 | 0.003181 | 34 |
| REAC | REAC:R-HSA-5218920 | VEGFR2 mediated vascular permeability | VEGFR2 mediated vascular permeability | 2 | 0.003181 | 34 |
| REAC | REAC:R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | Regulation of TP53 Activity through Acetylation | 2 | 0.003941 | 34 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 2 | 0.003941 | 34 |
| REAC | REAC:R-HSA-389356 | Co-stimulation by CD28 | Co-stimulation by CD28 | 2 | 0.004213 | 34 |
| REAC | REAC:R-HSA-397795 | G-protein beta:gamma signalling | G-protein beta:gamma signalling | 2 | 0.004494 | 34 |
| REAC | REAC:R-HSA-9607240 | FLT3 Signaling | FLT3 Signaling | 2 | 0.005706 | 34 |
| REAC | REAC:R-HSA-6804757 | Regulation of TP53 Degradation | Regulation of TP53 Degradation | 2 | 0.005706 | 34 |
| REAC | REAC:R-HSA-6806003 | Regulation of TP53 Expression and Degradation | Regulation of TP53 Expression and Degradation | 2 | 0.006032 | 34 |
| REAC | REAC:R-HSA-186712 | Regulation of beta-cell development | Regulation of beta-cell development | 2 | 0.006710 | 34 |
| REAC | REAC:R-HSA-165159 | MTOR signalling | MTOR signalling | 2 | 0.007425 | 34 |
| REAC | REAC:R-HSA-1227986 | Signaling by ERBB2 | Signaling by ERBB2 | 2 | 0.009369 | 34 |
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 2 | 0.012947 | 34 |
| REAC | REAC:R-HSA-9614085 | FOXO-mediated transcription | FOXO-mediated transcription | 2 | 0.019393 | 34 |
| REAC | REAC:R-HSA-388841 | Regulation of T cell activation by CD28 family | Regulation of T cell activation by CD28 family | 2 | 0.019988 | 34 |
| REAC | REAC:R-HSA-8948751 | Regulation of PTEN stability and activity | Regulation of PTEN stability and activity | 2 | 0.021206 | 34 |
| REAC | REAC:R-HSA-9009391 | Extra-nuclear estrogen signaling | Extra-nuclear estrogen signaling | 2 | 0.023100 | 34 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 2 | 0.029995 | 34 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 2 | 0.031482 | 34 |
| REAC | REAC:R-HSA-5628897 | TP53 Regulates Metabolic Genes | TP53 Regulates Metabolic Genes | 2 | 0.031482 | 34 |
| REAC | REAC:R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | RAB GEFs exchange GTP for GDP on RABs | 2 | 0.034562 | 34 |
| REAC | REAC:R-HSA-2219528 | PI3K/AKT Signaling in Cancer | PI3K/AKT Signaling in Cancer | 2 | 0.036966 | 34 |
| REAC | REAC:R-HSA-4420097 | VEGFA-VEGFR2 Pathway | VEGFA-VEGFR2 Pathway | 2 | 0.039450 | 34 |
| REAC | REAC:R-HSA-199418 | Negative regulation of the PI3K/AKT network | Negative regulation of the PI3K/AKT network | 2 | 0.043769 | 34 |
| REAC | REAC:R-HSA-194138 | Signaling by VEGF | Signaling by VEGF | 2 | 0.048311 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006446 | regulation of translational initiation | "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] | 3 | 0.000158 | 34 |
| GO:BP | GO:0006413 | translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] | 3 | 0.000571 | 34 |
| GO:BP | GO:2000765 | regulation of cytoplasmic translation | "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 2 | 0.012026 | 34 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 3 | 0.015410 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-877312 | Regulation of IFNG signaling | Regulation of IFNG signaling | 2 | 0.001107 | 35 |
| REAC | REAC:R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins | SUMOylation of DNA damage response and repair proteins | 2 | 0.042573 | 35 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0034399 | nuclear periphery | "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah] | 2 | 0.001467 | 35 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0300413 | Lung; macrophages[High] | Lung; macrophages[High] | 4 | 0.017502 | 35 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 4 | 0.023201 | 35 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 4 | 0.029546 | 35 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045727 | positive regulation of translation | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] | 3 | 0.000734 | 36 |
| GO:BP | GO:2000767 | positive regulation of cytoplasmic translation | "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 2 | 0.002170 | 36 |
| GO:BP | GO:2000765 | regulation of cytoplasmic translation | "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 2 | 0.012026 | 36 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 3 | 0.015410 | 36 |
| GO:BP | GO:0048255 | mRNA stabilization | "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid] | 2 | 0.042274 | 36 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-191-5p | hsa-mir-191-5p | hsa-mir-191-5p | 2 | 0.045834 | 36 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 2 | 0.047269 | 36 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030877 | beta-catenin destruction complex | "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] | 2 | 0.000223 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0070411 | I-SMAD binding | "Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 2 | 0.000886 | 37 |
| GO:MF | GO:0046332 | SMAD binding | "Binding to a SMAD signaling protein." [GOC:ai] | 2 | 0.022663 | 37 |
| GO:MF | GO:0008013 | beta-catenin binding | "Binding to a catenin beta subunit." [GOC:bf] | 2 | 0.042420 | 37 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 3 | 0.043502 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0009950 | dorsal/ventral axis specification | "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] | 2 | 0.001411 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4641257 | Degradation of AXIN | Degradation of AXIN | 2 | 0.006739 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 2 | 0.006792 | 37 |
| KEGG | KEGG:05217 | Basal cell carcinoma | Basal cell carcinoma | 2 | 0.008022 | 37 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 2 | 0.014985 | 37 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | Signaling pathways regulating pluripotency of stem cells | 2 | 0.041439 | 37 |
| KEGG | KEGG:05224 | Breast cancer | Breast cancer | 2 | 0.043784 | 37 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 2 | 0.044380 | 37 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 2 | 0.047421 | 37 |
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 2 | 0.049925 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4155 | Endometrial cancer | Endometrial cancer | 2 | 0.009940 | 37 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 2 | 0.013366 | 37 |
| WP | WP:WP4258 | lncRNA in canonical Wnt signaling and colorectal cancer | lncRNA in canonical Wnt signaling and colorectal cancer | 2 | 0.023637 | 37 |
| WP | WP:WP399 | Wnt signaling and pluripotency | Wnt signaling and pluripotency | 2 | 0.025123 | 37 |
| WP | WP:WP2064 | Neural crest differentiation | Neural crest differentiation | 2 | 0.025629 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2968 | Axin-SMAD3 complex | Axin-SMAD3 complex | 1 | 0.049932 | 37 |
| CORUM | CORUM:3004 | APC-AXIN1-CTNNB1 complex | APC-AXIN1-CTNNB1 complex | 1 | 0.049932 | 37 |
| CORUM | CORUM:3168 | DAXX-AXIN complex | DAXX-AXIN complex | 1 | 0.049932 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0019894 | kinesin binding | "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779] | 2 | 0.006658 | 38 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M04727_1 | Factor: CTCF; motif: ACCAGGKGGC; match class: 1 | Factor: CTCF; motif: ACCAGGKGGC; match class: 1 | 4 | 0.031782 | 38 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6804757 | Regulation of TP53 Degradation | Regulation of TP53 Degradation | 3 | 0.000022 | 39 |
| REAC | REAC:R-HSA-6806003 | Regulation of TP53 Expression and Degradation | Regulation of TP53 Expression and Degradation | 3 | 0.000024 | 39 |
| REAC | REAC:R-HSA-5633007 | Regulation of TP53 Activity | Regulation of TP53 Activity | 3 | 0.002024 | 39 |
| REAC | REAC:R-HSA-389357 | CD28 dependent PI3K/Akt signaling | CD28 dependent PI3K/Akt signaling | 2 | 0.003871 | 39 |
| REAC | REAC:R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | Constitutive Signaling by AKT1 E17K in Cancer | 2 | 0.005025 | 39 |
| REAC | REAC:R-HSA-5218920 | VEGFR2 mediated vascular permeability | VEGFR2 mediated vascular permeability | 2 | 0.005878 | 39 |
| REAC | REAC:R-HSA-389356 | Co-stimulation by CD28 | Co-stimulation by CD28 | 2 | 0.007784 | 39 |
| REAC | REAC:R-HSA-1257604 | PIP3 activates AKT signaling | PIP3 activates AKT signaling | 3 | 0.007911 | 39 |
| REAC | REAC:R-HSA-9006925 | Intracellular signaling by second messengers | Intracellular signaling by second messengers | 3 | 0.012294 | 39 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 3 | 0.022785 | 39 |
| REAC | REAC:R-HSA-388841 | Regulation of T cell activation by CD28 family | Regulation of T cell activation by CD28 family | 2 | 0.036849 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5094 | Orexin receptor pathway | Orexin receptor pathway | 3 | 0.000330 | 39 |
| WP | WP:WP481 | Insulin signaling | Insulin signaling | 3 | 0.001999 | 39 |
| WP | WP:WP2035 | Follicle stimulating hormone FSH signaling | Follicle stimulating hormone FSH signaling | 2 | 0.003640 | 39 |
| WP | WP:WP4923 | Autophagy | Autophagy | 2 | 0.005732 | 39 |
| WP | WP:WP4577 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway | Neurodegeneration with brain iron accumulation NBIA subtypes pathway | 2 | 0.012439 | 39 |
| WP | WP:WP4172 | PI3K Akt signaling | PI3K Akt signaling | 3 | 0.018411 | 39 |
| WP | WP:WP2795 | Cardiac hypertrophic response | Cardiac hypertrophic response | 2 | 0.018787 | 39 |
| WP | WP:WP2032 | Thyroid stimulating hormone TSH signaling | Thyroid stimulating hormone TSH signaling | 2 | 0.021688 | 39 |
| WP | WP:WP3584 | MECP2 and associated Rett syndrome | MECP2 and associated Rett syndrome | 2 | 0.034402 | 39 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 2 | 0.035352 | 39 |
| WP | WP:WP4806 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 2 | 0.045556 | 39 |
| WP | WP:WP5098 | T cell activation SARS CoV 2 | T cell activation SARS CoV 2 | 2 | 0.049995 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04150 | mTOR signaling pathway | mTOR signaling pathway | 3 | 0.001268 | 39 |
| KEGG | KEGG:04140 | Autophagy - animal | Autophagy - animal | 3 | 0.001530 | 39 |
| KEGG | KEGG:04136 | Autophagy - other | Autophagy - other | 2 | 0.004421 | 39 |
| KEGG | KEGG:04960 | Aldosterone-regulated sodium reabsorption | Aldosterone-regulated sodium reabsorption | 2 | 0.005931 | 39 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 3 | 0.015252 | 39 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 2 | 0.041073 | 39 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | Choline metabolism in cancer | 2 | 0.041922 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0106310 | protein serine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989] | 3 | 0.005558 | 39 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 3 | 0.020494 | 39 |
| GO:MF | GO:0004676 | 3-phosphoinositide-dependent protein kinase activity | "Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah] | 1 | 0.049891 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0031295 | T cell costimulation | "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation." [ISBN:0781735149] | 2 | 0.020353 | 39 |
| GO:BP | GO:0031294 | lymphocyte costimulation | "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation." [ISBN:0781735149] | 2 | 0.022101 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-3158-5p | hsa-mir-3158-5p | hsa-mir-3158-5p | 4 | 0.023256 | 39 |
| MIRNA | MIRNA:hsa-mir-646 | hsa-mir-646 | hsa-mir-646 | 4 | 0.032314 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | Postmitotic nuclear pore complex (NPC) reformation | 2 | 0.002502 | 40 |
| REAC | REAC:R-HSA-180746 | Nuclear import of Rev protein | Nuclear import of Rev protein | 2 | 0.004213 | 40 |
| REAC | REAC:R-HSA-177243 | Interactions of Rev with host cellular proteins | Interactions of Rev with host cellular proteins | 2 | 0.005082 | 40 |
| REAC | REAC:R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | Nuclear Envelope (NE) Reassembly | 2 | 0.021828 | 40 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0271111 | Kidney; bowman's capsule[≥Low] | Kidney; bowman's capsule[≥Low] | 2 | 0.039082 | 40 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4657 | 22q11 2 copy number variation syndrome | 22q11 2 copy number variation syndrome | 2 | 0.039259 | 40 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7543 | KPNB1-SMN-SPN complex | KPNB1-SMN-SPN complex | 1 | 0.049932 | 40 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0052720 | class II DNA-(apurinic or apyrimidinic site) endonuclease activity | "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends." [PMID:1698278] | 1 | 0.049724 | 41 |
| GO:MF | GO:0090580 | phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands | "Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand." [GOC:pde, GOC:rb, PMID:11238902] | 1 | 0.049724 | 41 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005674 | transcription factor TFIIF complex | "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077] | 1 | 0.049978 | 41 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2390 | CD98-LAT2-ITGB1 complex | CD98-LAT2-ITGB1 complex | 2 | 0.000089 | 42 |
| CORUM | CORUM:2413 | ITGA6-ITGB1 complex | ITGA6-ITGB1 complex | 1 | 0.049988 | 42 |
| CORUM | CORUM:2418 | ITGA4-ITGB1 complex | ITGA4-ITGB1 complex | 1 | 0.049988 | 42 |
| CORUM | CORUM:2421 | ITGA4-ITGB1-VCAM1 complex | ITGA4-ITGB1-VCAM1 complex | 1 | 0.049988 | 42 |
| CORUM | CORUM:2431 | ITGA2-ITGB1-COL6A3 complex | ITGA2-ITGB1-COL6A3 complex | 1 | 0.049988 | 42 |
| CORUM | CORUM:2432 | ITGA2-ITGB1 complex | ITGA2-ITGB1 complex | 1 | 0.049988 | 42 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-210991 | Basigin interactions | Basigin interactions | 2 | 0.002719 | 42 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0089718 | amino acid import across plasma membrane | "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] | 2 | 0.008639 | 42 |
| GO:BP | GO:1902475 | L-alpha-amino acid transmembrane transport | "The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore." [GOC:kmv, GOC:TermGenie, PMID:14668347] | 2 | 0.016353 | 42 |
| GO:BP | GO:0015807 | L-amino acid transport | "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] | 2 | 0.027711 | 42 |
| GO:BP | GO:0003333 | amino acid transmembrane transport | "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb] | 2 | 0.037641 | 42 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 2 | 0.014486 | 42 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 2 | 0.014486 | 42 |
| GO:CC | GO:0034677 | integrin alpha7-beta1 complex | "An integrin complex that comprises one alpha7 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.024990 | 42 |
| GO:CC | GO:0044225 | apical pole of neuron | "Portion of a neuron cell soma closest to the point where the apical dendrite emerges." [NIF_Subcellular:sao1186862860] | 1 | 0.024990 | 42 |
| GO:CC | GO:0034682 | integrin alphav-beta1 complex | "An integrin complex that comprises one alphav subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 42 |
| GO:CC | GO:0034681 | integrin alpha11-beta1 complex | "An integrin complex that comprises one alpha11 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 42 |
| GO:CC | GO:0034680 | integrin alpha10-beta1 complex | "An integrin complex that comprises one alpha10 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 42 |
| GO:CC | GO:0034679 | integrin alpha9-beta1 complex | "An integrin complex that comprises one alpha9 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 42 |
| GO:CC | GO:0034678 | integrin alpha8-beta1 complex | "An integrin complex that comprises one alpha8 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 42 |
| GO:CC | GO:0034675 | integrin alpha6-beta1 complex | "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 42 |
| GO:CC | GO:0034674 | integrin alpha5-beta1 complex | "An integrin complex that comprises one alpha5 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 42 |
| GO:CC | GO:0034667 | integrin alpha3-beta1 complex | "An integrin complex that comprises one alpha3 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 42 |
| GO:CC | GO:0034665 | integrin alpha1-beta1 complex | "An integrin complex that comprises one alpha1 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 42 |
| GO:CC | GO:1990184 | amino acid transport complex | "A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane." [GOC:kmv, PMID:14668347] | 1 | 0.049978 | 42 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0001618 | virus receptor activity | "Combining with a virus component and mediating entry of the virus into the cell." [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183] | 2 | 0.015096 | 42 |
| GO:MF | GO:0140272 | exogenous protein binding | "Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein." [PMID:28861068] | 2 | 0.015483 | 42 |
| GO:MF | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity | "Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] | 1 | 0.049724 | 42 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 3 | 0.019640 | 42 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 3 | 0.031240 | 42 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 3 | 0.040697 | 42 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03271 | Virion - Rotavirus | Virion - Rotavirus | 1 | 0.035006 | 42 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:4000141 | Left ventricular dilatation | Enlargement of the chamber of the left heart ventricle. | 1 | 0.049962 | 42 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0035403 | histone H3T6 kinase activity | "Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3." [GOC:bf] | 1 | 0.049891 | 43 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | Metabolism of water-soluble vitamins and cofactors | 2 | 0.034607 | 44 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-548ag | hsa-mir-548ag | hsa-mir-548ag | 3 | 0.047161 | 44 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7190 | 3-methylcrotonyl-CoA carboxylase | 3-methylcrotonyl-CoA carboxylase | 1 | 0.049932 | 44 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1905202 | methylcrotonoyl-CoA carboxylase complex | "A protein complex capable of methylcrotonoyl-CoA carboxylase activity. In mammals, it is a mitochondrial complex comprising a dodecamer of 6 alpha and 6 beta subunits: MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation; MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, GOC:PARL, PMID:15868465, PMID:17360195, PMID:22158123, PMID:22869039] | 1 | 0.049978 | 44 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097409 | glial cytoplasmic inclusion | "Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy." [NIF_Subcellular:nlx_subcell_20090703, PMID:21562886, PMID:2559165] | 1 | 0.02499 | 45 |
| GO:CC | GO:0097414 | classical Lewy body | "Cytoplasmic inclusion, 5 to 15 micrometers in diameter, with a dense core surrounded by a halo of 10 to 20 nm wide radially oriented alpha-synuclein fibrils." [NIF_Subcellular:sao4749542545] | 1 | 0.02499 | 45 |
| GO:CC | GO:0097462 | Lewy neurite | "Elongated neuronal process, often with side branches and more than one branching point, described in brains of patients with Parkinson's disease. Lewy neurites stain positively for ubiquitin in brainstem and forebrain regions affected in Parkinson's disease." [NIF_Subcellular:sao601362597] | 1 | 0.02499 | 45 |
| GO:CC | GO:1990038 | Lewy body corona | "The periphery of a Lewy body. In Parkinson's disease, it contains spherical accumulations of filaments arranged in a loose, radiating array." [NIF_Subcellular:sao5764355747] | 1 | 0.02499 | 45 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0031137 | Storage in hepatocytes | Hepatocytes (liver parenchymal cells) exhibit a bloated appearance because of expansion of the cytoplasm by accumulated material. | 3 | 0.037393 | 46 |
| HP | HP:0034644 | Abnormal liver metabolite concentration | The concentration of a metabolite in the liver is above or below the limits of normal. | 3 | 0.044271 | 46 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP1941 | Peroxisomal beta oxidation of tetracosanoyl CoA | Peroxisomal beta oxidation of tetracosanoyl CoA | 1 | 0.039736 | 46 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0033989 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity | "Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O." [EC:4.2.1.107] | 1 | 0.049724 | 46 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0140225 | DNA topoisomerase III-beta-TDRD3 complex | "A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities." [GOC:lnp, PMID:23912945, PMID:28176834] | 1 | 0.049978 | 47 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-3137 | hsa-mir-3137 | hsa-mir-3137 | 3 | 0.025965 | 48 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0031114 | regulation of microtubule depolymerization | "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah] | 2 | 0.004034 | 49 |
| GO:BP | GO:0007019 | microtubule depolymerization | "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] | 2 | 0.008300 | 49 |
| GO:BP | GO:1901879 | regulation of protein depolymerization | "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] | 2 | 0.027711 | 49 |
| GO:BP | GO:0031110 | regulation of microtubule polymerization or depolymerization | "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] | 2 | 0.032157 | 49 |
| GO:BP | GO:0051261 | protein depolymerization | "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] | 2 | 0.049082 | 49 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0044304 | main axon | "The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites." [NIF_Subcellular:sao1596975044] | 2 | 0.006082 | 49 |
| GO:CC | GO:0005875 | microtubule associated complex | "Any multimeric complex connected to a microtubule." [GOC:jl] | 2 | 0.028212 | 49 |
| GO:CC | GO:0150001 | primary dendrite | "A dendrite emerging from the cell body (the soma) of a neuron." [GOC:aruk, GOC:bc] | 1 | 0.049978 | 49 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03250 | Viral life cycle - HIV-1 | Viral life cycle - HIV-1 | 2 | 0.007768 | 49 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0090923 | Cerebellum; GLUC cells - cytoplasm/membrane[High] | Cerebellum; GLUC cells - cytoplasm/membrane[High] | 2 | 0.016778 | 49 |
| HPA | HPA:0090922 | Cerebellum; GLUC cells - cytoplasm/membrane[≥Medium] | Cerebellum; GLUC cells - cytoplasm/membrane[≥Medium] | 2 | 0.046756 | 49 |
| HPA | HPA:0091003 | Cerebellum; molecular layer cells - cytoplasm/membrane[High] | Cerebellum; molecular layer cells - cytoplasm/membrane[High] | 2 | 0.048350 | 49 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4654 | hsa-mir-4654 | hsa-mir-4654 | 3 | 0.039504 | 49 |
| MIRNA | MIRNA:hsa-mir-4769-5p | hsa-mir-4769-5p | hsa-mir-4769-5p | 3 | 0.039654 | 49 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0030026 | Squared superior portion of helix | Flattening instead of curving or rounded superior helix, allowing the superior helix to run more horizontally than usual. | 1 | 0.049962 | 49 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990788 | GLI-SUFU complex | "A protein repressing GLI's transcription factor activity when SMO signaling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins." [GOC:bhm, PMID:24311597] | 2 | 0.000014 | 50 |
| GO:CC | GO:0097546 | ciliary base | "Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444] | 2 | 0.002436 | 50 |
| GO:CC | GO:0097542 | ciliary tip | "Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417] | 2 | 0.002542 | 50 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0021776 | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification | "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15936325] | 2 | 0.000020 | 50 |
| GO:BP | GO:0021910 | smoothened signaling pathway involved in ventral spinal cord patterning | "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:11262869] | 2 | 0.000020 | 50 |
| GO:BP | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification | "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] | 2 | 0.000020 | 50 |
| GO:BP | GO:0021521 | ventral spinal cord interneuron specification | "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.000142 | 50 |
| GO:BP | GO:0060573 | cell fate specification involved in pattern specification | "The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:tb] | 2 | 0.000142 | 50 |
| GO:BP | GO:0021520 | spinal cord motor neuron cell fate specification | "The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.000373 | 50 |
| GO:BP | GO:0060579 | ventral spinal cord interneuron fate commitment | "The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph] | 2 | 0.000373 | 50 |
| GO:BP | GO:0060581 | cell fate commitment involved in pattern specification | "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph] | 2 | 0.000373 | 50 |
| GO:BP | GO:0021514 | ventral spinal cord interneuron differentiation | "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] | 2 | 0.000529 | 50 |
| GO:BP | GO:0021513 | spinal cord dorsal/ventral patterning | "The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.000814 | 50 |
| GO:BP | GO:0021511 | spinal cord patterning | "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.001038 | 50 |
| GO:BP | GO:0021522 | spinal cord motor neuron differentiation | "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] | 2 | 0.002949 | 50 |
| GO:BP | GO:0045879 | negative regulation of smoothened signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators] | 2 | 0.004034 | 50 |
| GO:BP | GO:0048665 | neuron fate specification | "The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph] | 2 | 0.004034 | 50 |
| GO:BP | GO:0021517 | ventral spinal cord development | "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.007014 | 50 |
| GO:BP | GO:0021515 | cell differentiation in spinal cord | "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] | 2 | 0.008300 | 50 |
| GO:BP | GO:0048663 | neuron fate commitment | "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph] | 2 | 0.017794 | 50 |
| GO:BP | GO:0009953 | dorsal/ventral pattern formation | "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] | 2 | 0.025907 | 50 |
| GO:BP | GO:0008589 | regulation of smoothened signaling pathway | "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators] | 2 | 0.026502 | 50 |
| GO:BP | GO:0021510 | spinal cord development | "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.032819 | 50 |
| GO:BP | GO:0001708 | cell fate specification | "The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate." [GOC:go_curators] | 2 | 0.042792 | 50 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP47 | Hedgehog signaling | Hedgehog signaling | 2 | 0.000136 | 50 |
| WP | WP:WP4249 | Hedgehog signaling | Hedgehog signaling | 2 | 0.001025 | 50 |
| WP | WP:WP5234 | Bardet Biedl syndrome | Bardet Biedl syndrome | 2 | 0.004346 | 50 |
| WP | WP:WP4803 | Ciliopathies | Ciliopathies | 2 | 0.019115 | 50 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04340 | Hedgehog signaling pathway | Hedgehog signaling pathway | 2 | 0.001132 | 50 |
| KEGG | KEGG:05217 | Basal cell carcinoma | Basal cell carcinoma | 2 | 0.001436 | 50 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0010644 | Midnasal stenosis | Abnormal narrowing (stenosis) of the midnasal cavity, i.e., of the middle nasal meatus, which in neonates can cause respiratory distress. | 2 | 0.004347 | 50 |
| HP | HP:0010641 | Abnormality of the midnasal cavity | Abnormality of the midnasal cavity which includes the cavity between the nares and the choanae. | 2 | 0.004347 | 50 |
| HP | HP:0010640 | Abnormal nasal cavity morphology | Abnormality of the nasal cavity (the cavity includes and starts at the nares and reaches all the way through to the and includes the choanae, the posterior nasal apertures). | 2 | 0.004926 | 50 |
| HP | HP:0009914 | Cyclopia | Cyclopia is a congenital abnormality in which there is only one eye. That eye is centrally placed in the area normally occupied by the root of the nose. | 2 | 0.008367 | 50 |
| HP | HP:0010653 | Abnormality of the falx cerebri | An abnormality of the Falx cerebri. | 2 | 0.011772 | 50 |
| HP | HP:0010652 | Abnormal dura mater morphology | An abnormality of the Dura mater. | 2 | 0.012714 | 50 |
| HP | HP:0006315 | Solitary median maxillary central incisor | A single maxillary central incisor positioned in the midline with morphological symmetry of the crown and bordered by lateral incisors. | 2 | 0.012714 | 50 |
| HP | HP:0040086 | Abnormal prolactin level | Abnormal prolactin level | 2 | 0.015757 | 50 |
| HP | HP:0002920 | Decreased circulating ACTH concentration | The concentration of corticotropin, also known as adrenocorticotropic hormone (ACTH), is below the lower limit of normal in the blood circulation. | 2 | 0.015757 | 50 |
| HP | HP:0000871 | Panhypopituitarism | A pituitary functional deficit affecting all the anterior pituitary hormones (growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotropic hormone, and prolactin). | 2 | 0.016843 | 50 |
| HP | HP:0011751 | Abnormal posterior pituitary morphogenesis | An abnormality of the neurohypophysis, which is also known as the posterior lobe of the hypophysis. | 2 | 0.022820 | 50 |
| HP | HP:0008245 | Pituitary hypothyroidism | A type of hypothyroidism that results from a defect in thyroid-stimulating hormone secretion. | 2 | 0.025464 | 50 |
| HP | HP:0002247 | Duodenal atresia | A developmental defect resulting in complete obliteration of the duodenal lumen, that is, an abnormal closure of the duodenum. | 2 | 0.035860 | 50 |
| HP | HP:0009800 | Maternal diabetes | Maternal diabetes can either be a gestational, mostly type 2 diabetes, or a type 1 diabetes. Essential is the resulting maternal hyperglycemia as a non-specific teratogen, imposing the same risk of congenital malformations to pregnant women with both type 1 and type2 diabetes. | 2 | 0.035860 | 50 |
| HP | HP:0011043 | Abnormal circulating adrenocorticotropin concentration | An abnormal concentration of corticotropin in the blood. | 2 | 0.040859 | 50 |
| HP | HP:0000446 | Narrow nasal bridge | Decreased width of the bony bridge of the nose. | 2 | 0.044372 | 50 |
| HP | HP:0012285 | Abnormal hypothalamus physiology | An abnormal functionality of the hypothalamus. | 2 | 0.049914 | 50 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6819-5p | hsa-mir-6819-5p | hsa-mir-6819-5p | 2 | 0.015145 | 50 |
| MIRNA | MIRNA:hsa-mir-6737-5p | hsa-mir-6737-5p | hsa-mir-6737-5p | 2 | 0.015145 | 50 |
| MIRNA | MIRNA:hsa-mir-6747-5p | hsa-mir-6747-5p | hsa-mir-6747-5p | 2 | 0.024035 | 50 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5610783 | Degradation of GLI2 by the proteasome | Degradation of GLI2 by the proteasome | 2 | 0.016008 | 50 |
| REAC | REAC:R-HSA-5632684 | Hedgehog 'on' state | Hedgehog 'on' state | 2 | 0.032239 | 50 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6668 | GLIS3-SUFU complex | GLIS3-SUFU complex | 1 | 0.049932 | 50 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051373 | FATZ binding | "Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components." [PMID:10984498, PMID:11699871] | 2 | 0.000049 | 51 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0014888 | striated muscle adaptation | "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] | 2 | 0.007325 | 51 |
| GO:BP | GO:0045214 | sarcomere organization | "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] | 2 | 0.008639 | 51 |
| GO:BP | GO:0030239 | myofibril assembly | "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] | 2 | 0.019295 | 51 |
| GO:BP | GO:0043500 | muscle adaptation | "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] | 2 | 0.036932 | 51 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030018 | Z disc | "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] | 2 | 0.019435 | 51 |
| GO:CC | GO:0031674 | I band | "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] | 2 | 0.024110 | 51 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11082_1 | Factor: SREBP-1; motif: RNCACGCSAY; match class: 1 | Factor: SREBP-1; motif: RNCACGCSAY; match class: 1 | 3 | 0.017654 | 52 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005777 | peroxisome | "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] | 2 | 0.023783 | 52 |
| GO:CC | GO:0042579 | microbody | "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732] | 2 | 0.023783 | 52 |
| GO:CC | GO:0031967 | organelle envelope | "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] | 3 | 0.039773 | 52 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3953 | mRNA protein and metabolite inducation pathway by cyclosporin A | mRNA protein and metabolite inducation pathway by cyclosporin A | 2 | 0.000024 | 53 |
| WP | WP:WP3 | Transcriptional activation by NRF2 in response to phytochemicals | Transcriptional activation by NRF2 in response to phytochemicals | 2 | 0.000119 | 53 |
| WP | WP:WP2435 | Quercetin and Nf kB AP 1 induced apoptosis | Quercetin and Nf kB AP 1 induced apoptosis | 2 | 0.000136 | 53 |
| WP | WP:WP4206 | Hereditary leiomyomatosis and renal cell carcinoma pathway | Hereditary leiomyomatosis and renal cell carcinoma pathway | 2 | 0.000216 | 53 |
| WP | WP:WP4357 | NRF2 ARE regulation | NRF2 ARE regulation | 2 | 0.000287 | 53 |
| WP | WP:WP3612 | Photodynamic therapy induced NFE2L2 NRF2 survival signaling | Photodynamic therapy induced NFE2L2 NRF2 survival signaling | 2 | 0.000287 | 53 |
| WP | WP:WP5113 | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway | 2 | 0.000563 | 53 |
| WP | WP:WP5477 | Molecular pathway for oxidative stress | Molecular pathway for oxidative stress | 2 | 0.001335 | 53 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 2 | 0.003067 | 53 |
| WP | WP:WP4874 | CAMKK2 pathway | CAMKK2 pathway | 2 | 0.006807 | 53 |
| WP | WP:WP2884 | NRF2 pathway | NRF2 pathway | 2 | 0.011206 | 53 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5805 | PGAM5-KEAP1-NRF2 complex | PGAM5-KEAP1-NRF2 complex | 2 | 0.000089 | 53 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902882 | regulation of response to oxidative stress | "Any process that modulates the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] | 2 | 0.003803 | 53 |
| GO:BP | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 2 | 0.036932 | 53 |
| GO:BP | GO:1901800 | positive regulation of proteasomal protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] | 2 | 0.042792 | 53 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | Fluid shear stress and atherosclerosis | 2 | 0.006950 | 53 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 2 | 0.010068 | 53 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | Chemical carcinogenesis - reactive oxygen species | 2 | 0.017872 | 53 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 2 | 0.025716 | 53 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 3 | 0.008648 | 53 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 3 | 0.044579 | 53 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 2 | 0.040296 | 53 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | Carboxyterminal post-translational modifications of tubulin | 2 | 0.008962 | 54 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0034451 | centriolar satellite | "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812] | 2 | 0.01856 | 54 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-27b-5p | hsa-mir-27b-5p | hsa-mir-27b-5p | 2 | 0.010624 | 55 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 2 | 0.023648 | 55 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4085023 | Defective GFPT1 causes CMSTA1 | Defective GFPT1 causes CMSTA1 | 1 | 0.049932 | 55 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | WNT5A-dependent internalization of FZD4 | 2 | 0.000952 | 56 |
| REAC | REAC:R-HSA-4086400 | PCP/CE pathway | PCP/CE pathway | 2 | 0.037785 | 56 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04916 | Melanogenesis | Melanogenesis | 2 | 0.003713 | 56 |
| KEGG | KEGG:04150 | mTOR signaling pathway | mTOR signaling pathway | 2 | 0.008774 | 56 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 2 | 0.010068 | 56 |
| KEGG | KEGG:04310 | Wnt signaling pathway | Wnt signaling pathway | 2 | 0.011065 | 56 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP363 | Wnt signaling NetPath | Wnt signaling NetPath | 2 | 0.005509 | 56 |
| WP | WP:WP399 | Wnt signaling and pluripotency | Wnt signaling and pluripotency | 2 | 0.025123 | 56 |
| WP | WP:WP428 | Wnt signaling | Wnt signaling | 2 | 0.032085 | 56 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1268a | hsa-mir-1268a | hsa-mir-1268a | 2 | 0.007237 | 56 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0130652 | Colon; fibroblasts[≥Medium] | Colon; fibroblasts[≥Medium] | 2 | 0.013756 | 57 |
| HPA | HPA:0151343 | Duodenum; glands of Brunner[High] | Duodenum; glands of Brunner[High] | 2 | 0.016150 | 57 |
| HPA | HPA:0130651 | Colon; fibroblasts[≥Low] | Colon; fibroblasts[≥Low] | 2 | 0.016778 | 57 |
| HPA | HPA:0481353 | Small intestine; paneth cells[High] | Small intestine; paneth cells[High] | 2 | 0.033601 | 57 |
| HPA | HPA:0131333 | Colon; mucosal lymphoid cells[High] | Colon; mucosal lymphoid cells[High] | 2 | 0.036339 | 57 |
| HPA | HPA:0151353 | Duodenum; paneth cells[High] | Duodenum; paneth cells[High] | 2 | 0.041634 | 57 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 2 | 0.046756 | 57 |
| HPA | HPA:0030893 | Appendix; goblet cells[High] | Appendix; goblet cells[High] | 2 | 0.048350 | 57 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047931 | glucosamine kinase activity | "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H+." [RHEA:10948] | 1 | 0.049724 | 57 |
| GO:MF | GO:0050137 | NADPH peroxidase activity | "Catalysis of the reaction: H2O2 + H+ + NADPH = 2 H2O + NADP+." [EC:1.11.1.2, RHEA:15173] | 1 | 0.049724 | 57 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5619056 | Defective HK1 causes hexokinase deficiency (HK deficiency) | Defective HK1 causes hexokinase deficiency (HK deficiency) | 1 | 0.049932 | 57 |
| REAC | REAC:R-HSA-5263617 | Metabolism of ingested MeSeO2H into MeSeH | Metabolism of ingested MeSeO2H into MeSeH | 1 | 0.049932 | 57 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:6000559 | Reduced erythrocyte hexokinase activity | Activity or concentration of hexokinase (EC 2.7.1.1) in red blood cells below the lower limit of normal. Arginase catalyzes the last step of the urea cycle. | 1 | 0.049962 | 57 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0003075 | Hypoproteinemia | A decreased concentration of protein in the blood. | 2 | 0.025361 | 58 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0061826 | podosome ring | "The ring structure surrounding the podosome core, containing proteins such as vinculin and talin." [PMID:23158496] | 1 | 0.024990 | 59 |
| GO:CC | GO:0090636 | outer dense plaque of desmosome | "The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane." [PMID:20066089] | 1 | 0.024990 | 59 |
| GO:CC | GO:0090637 | inner dense plaque of desmosome | "The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane." [PMID:20066089] | 1 | 0.024990 | 59 |
| GO:CC | GO:0005912 | adherens junction | "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] | 2 | 0.039866 | 59 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034313 | Hyperdynamic left ventricular ejection fraction | An abnormally increased ejection fraction of the left ventricle, usually defined as a left ventricular ejection fraction greater than 70 percent. | 1 | 0.049962 | 59 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5477 | Molecular pathway for oxidative stress | Molecular pathway for oxidative stress | 2 | 0.005992 | 60 |
| WP | WP:WP5087 | Pleural mesothelioma | Pleural mesothelioma | 3 | 0.007962 | 60 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 2 | 0.016879 | 60 |
| WP | WP:WP4874 | CAMKK2 pathway | CAMKK2 pathway | 2 | 0.030404 | 60 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 2 | 0.048665 | 60 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:75 | TSC1-TSC2 complex | TSC1-TSC2 complex | 1 | 0.049932 | 60 |
| CORUM | CORUM:7157 | TSC1-TSC2 complex | TSC1-TSC2 complex | 1 | 0.049932 | 60 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0062152 | mRNA (cytidine-5-)-methyltransferase activity | "Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H+ + S-adenosyl-L-homocysteine." [PMID:22395603, PMID:23871666, RHEA:61464] | 1 | 0.049724 | 61 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003713 | transcription coactivator activity | "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 3 | 0.000647 | 62 |
| GO:MF | GO:0003712 | transcription coregulator activity | "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] | 3 | 0.004758 | 62 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 3 | 0.044579 | 62 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00231_1 | Factor: MEF-2A; motif: NNNNNNKCTAWAAATAGMNNNN; match class: 1 | Factor: MEF-2A; motif: NNNNNNKCTAWAAATAGMNNNN; match class: 1 | 2 | 0.009405 | 62 |
| TF | TF:M00026_1 | Factor: RSRFC4; motif: RNKCTATTTWTAGMWN; match class: 1 | Factor: RSRFC4; motif: RNKCTATTTWTAGMWN; match class: 1 | 2 | 0.029729 | 62 |
| TF | TF:M12042_1 | Factor: TEF-1; motif: NRCATWCCN; match class: 1 | Factor: TEF-1; motif: NRCATWCCN; match class: 1 | 3 | 0.040767 | 62 |
| TF | TF:M00407_1 | Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN; match class: 1 | Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN; match class: 1 | 2 | 0.042031 | 62 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 2 | 0.010812 | 62 |
| GO:BP | GO:0051145 | smooth muscle cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai] | 2 | 0.014087 | 62 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 2 | 0.014087 | 62 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 2 | 0.019295 | 62 |
| GO:BP | GO:0061614 | miRNA transcription | "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] | 2 | 0.019809 | 62 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 2 | 0.027103 | 62 |
| GO:BP | GO:0010586 | miRNA metabolic process | "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] | 2 | 0.037641 | 62 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6451 | MAK-ACTR-AR complex | MAK-ACTR-AR complex | 1 | 0.049932 | 62 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:657 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) | 2 | 0.000148 | 63 |
| CORUM | CORUM:1059 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) | 2 | 0.000148 | 63 |
| CORUM | CORUM:1060 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) | 2 | 0.000148 | 63 |
| CORUM | CORUM:1072 | SNX complex (SNX2), oligomeric | SNX complex (SNX2), oligomeric | 1 | 0.049932 | 63 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030904 | retromer complex | "A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35." [GOC:bf, PMID:26220253, PMID:27385586, PMID:9700157] | 2 | 0.000195 | 63 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-7158-3p | hsa-mir-7158-3p | hsa-mir-7158-3p | 2 | 0.010532 | 63 |
| MIRNA | MIRNA:hsa-mir-203b-3p | hsa-mir-203b-3p | hsa-mir-203b-3p | 2 | 0.011945 | 63 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0042147 | retrograde transport, endosome to Golgi | "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697] | 2 | 0.012378 | 63 |
| GO:BP | GO:0016482 | cytosolic transport | "The directed movement of substances or organelles within the cytosol." [GOC:ai] | 2 | 0.023257 | 63 |
| GO:BP | GO:2000331 | regulation of terminal button organization | "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] | 1 | 0.049542 | 63 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04144 | Endocytosis | Endocytosis | 2 | 0.022517 | 63 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7586 | FOXO1-ESR1 complex | FOXO1-ESR1 complex | 1 | 0.049932 | 64 |
| CORUM | CORUM:7588 | APP(AICD)-FOXO1 complex | APP(AICD)-FOXO1 complex | 1 | 0.049932 | 64 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4641258 | Degradation of DVL | Degradation of DVL | 2 | 0.014437 | 65 |
| REAC | REAC:R-HSA-4086400 | PCP/CE pathway | PCP/CE pathway | 2 | 0.037785 | 65 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:29 | PA28gamma complex | PA28gamma complex | 1 | 0.024966 | 65 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3872 | Apoptosis regulation by parathyroid hormone related protein | Apoptosis regulation by parathyroid hormone related protein | 3 | 0.000001 | 66 |
| WP | WP:WP4318 | Mitochondrial fission and fusion | Mitochondrial fission and fusion | 2 | 0.000399 | 66 |
| WP | WP:WP4864 | Host pathogen interaction of human coronaviruses apoptosis | Host pathogen interaction of human coronaviruses apoptosis | 2 | 0.001072 | 66 |
| WP | WP:WP3614 | Photodynamic therapy induced HIF 1 survival signaling | Photodynamic therapy induced HIF 1 survival signaling | 2 | 0.003397 | 66 |
| WP | WP:WP2447 | Amyotrophic lateral sclerosis ALS | Amyotrophic lateral sclerosis ALS | 2 | 0.003585 | 66 |
| WP | WP:WP3611 | Photodynamic therapy induced AP 1 survival signaling | Photodynamic therapy induced AP 1 survival signaling | 2 | 0.006241 | 66 |
| WP | WP:WP4806 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 2 | 0.017715 | 66 |
| WP | WP:WP4298 | Acute viral myocarditis | Acute viral myocarditis | 2 | 0.018140 | 66 |
| WP | WP:WP254 | Apoptosis | Apoptosis | 2 | 0.019006 | 66 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 2 | 0.019447 | 66 |
| WP | WP:WP5098 | T cell activation SARS CoV 2 | T cell activation SARS CoV 2 | 2 | 0.019447 | 66 |
| WP | WP:WP231 | TNF alpha signaling | TNF alpha signaling | 2 | 0.019892 | 66 |
| WP | WP:WP1772 | Apoptosis modulation and signaling | Apoptosis modulation and signaling | 2 | 0.020343 | 66 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 2 | 0.022670 | 66 |
| WP | WP:WP5470 | Effect of omega 3 PUFA on Huntington 39 s disease pathways | Effect of omega 3 PUFA on Huntington 39 s disease pathways | 2 | 0.036183 | 66 |
| WP | WP:WP4630 | Measles virus infection | Measles virus infection | 2 | 0.046464 | 66 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051434 | BH3 domain binding | "Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] | 2 | 0.000074 | 66 |
| GO:MF | GO:0051400 | BH domain binding | "Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] | 2 | 0.000324 | 66 |
| GO:MF | GO:0070513 | death domain binding | "Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531] | 2 | 0.000383 | 66 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097136 | Bcl-2 family protein complex | "A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed." [GOC:so, PMID:14634621] | 2 | 0.000124 | 66 |
| GO:CC | GO:0097144 | BAX complex | "An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] | 1 | 0.024990 | 66 |
| GO:CC | GO:0097145 | BAK complex | "An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] | 1 | 0.049978 | 66 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04215 | Apoptosis - multiple species | Apoptosis - multiple species | 2 | 0.000365 | 66 |
| KEGG | KEGG:01524 | Platinum drug resistance | Platinum drug resistance | 2 | 0.001879 | 66 |
| KEGG | KEGG:04115 | p53 signaling pathway | p53 signaling pathway | 2 | 0.001986 | 66 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 2 | 0.002095 | 66 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 2 | 0.002095 | 66 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 2 | 0.002265 | 66 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 2 | 0.003077 | 66 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 2 | 0.006650 | 66 |
| KEGG | KEGG:05162 | Measles | Measles | 2 | 0.006950 | 66 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 2 | 0.010068 | 66 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | Transcriptional misregulation in cancer | 2 | 0.013480 | 66 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | Human immunodeficiency virus 1 infection | 2 | 0.016133 | 66 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | Lipid and atherosclerosis | 2 | 0.016755 | 66 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 2 | 0.017389 | 66 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 2 | 0.022154 | 66 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 2 | 0.025716 | 66 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 2 | 0.048303 | 66 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] | 3 | 0.000646 | 66 |
| GO:BP | GO:0035234 | ectopic germ cell programmed cell death | "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] | 2 | 0.001038 | 66 |
| GO:BP | GO:0010623 | programmed cell death involved in cell development | "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 2 | 0.002204 | 66 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 3 | 0.002929 | 66 |
| GO:BP | GO:1902110 | positive regulation of mitochondrial membrane permeability involved in apoptotic process | "Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129] | 2 | 0.004765 | 66 |
| GO:BP | GO:1902686 | mitochondrial outer membrane permeabilization involved in programmed cell death | "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie, PMID:20151314] | 2 | 0.005287 | 66 |
| GO:BP | GO:0090199 | regulation of release of cytochrome c from mitochondria | "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 2 | 0.005287 | 66 |
| GO:BP | GO:0035794 | positive regulation of mitochondrial membrane permeability | "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf, PMID:12546810] | 2 | 0.005836 | 66 |
| GO:BP | GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process | "Any regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129] | 2 | 0.006411 | 66 |
| GO:BP | GO:1905710 | positive regulation of membrane permeability | "Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane." [PMID:27482894] | 2 | 0.007014 | 66 |
| GO:BP | GO:0001836 | release of cytochrome c from mitochondria | "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation." [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217] | 2 | 0.008984 | 66 |
| GO:BP | GO:0010332 | response to gamma radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators] | 2 | 0.008984 | 66 |
| GO:BP | GO:0046902 | regulation of mitochondrial membrane permeability | "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf] | 2 | 0.010061 | 66 |
| GO:BP | GO:0001541 | ovarian follicle development | "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] | 2 | 0.011198 | 66 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 3 | 0.011913 | 66 |
| GO:BP | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708] | 2 | 0.014527 | 66 |
| GO:BP | GO:0090559 | regulation of membrane permeability | "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane." [GOC:kmv, PMID:22677064] | 2 | 0.015887 | 66 |
| GO:BP | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705] | 2 | 0.016353 | 66 |
| GO:BP | GO:0051881 | regulation of mitochondrial membrane potential | "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai] | 2 | 0.017307 | 66 |
| GO:BP | GO:0038034 | signal transduction in absence of ligand | "The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor." [GOC:al, GOC:ppm, GOC:pr, PMID:15044679] | 2 | 0.017307 | 66 |
| GO:BP | GO:0097194 | execution phase of apoptosis | "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595] | 2 | 0.020330 | 66 |
| GO:BP | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] | 2 | 0.023595 | 66 |
| GO:BP | GO:1904019 | epithelial cell apoptotic process | "Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015] | 2 | 0.024163 | 66 |
| GO:BP | GO:1905897 | regulation of response to endoplasmic reticulum stress | "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] | 2 | 0.024738 | 66 |
| GO:BP | GO:2000106 | regulation of leukocyte apoptotic process | "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] | 2 | 0.026502 | 66 |
| GO:BP | GO:0008637 | apoptotic mitochondrial changes | "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis] | 2 | 0.035534 | 66 |
| GO:BP | GO:0008585 | female gonad development | "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb] | 2 | 0.036229 | 66 |
| GO:BP | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] | 2 | 0.036932 | 66 |
| GO:BP | GO:0046545 | development of primary female sexual characteristics | "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai] | 2 | 0.039079 | 66 |
| GO:BP | GO:0010821 | regulation of mitochondrion organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] | 2 | 0.044324 | 66 |
| GO:BP | GO:0007006 | mitochondrial membrane organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 2 | 0.045101 | 66 |
| GO:BP | GO:0071887 | leukocyte apoptotic process | "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] | 2 | 0.046673 | 66 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 2 | 0.006494 | 66 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2000 | BAX homo-oligomer complex | BAX homo-oligomer complex | 1 | 0.049932 | 66 |
| CORUM | CORUM:3492 | BAX homo-oligomer complex | BAX homo-oligomer complex | 1 | 0.049932 | 66 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP363 | Wnt signaling NetPath | Wnt signaling NetPath | 2 | 0.001227 | 67 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 2 | 0.002147 | 67 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 2 | 0.003067 | 67 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 2 | 0.003771 | 67 |
| WP | WP:WP2571 | Polycystic kidney disease pathway | Polycystic kidney disease pathway | 2 | 0.003958 | 67 |
| WP | WP:WP5098 | T cell activation SARS CoV 2 | T cell activation SARS CoV 2 | 2 | 0.004346 | 67 |
| WP | WP:WP5475 | Hallmark of cancer sustaining proliferative signaling | Hallmark of cancer sustaining proliferative signaling | 2 | 0.005396 | 67 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 2 | 0.007185 | 67 |
| WP | WP:WP1984 | Integrated breast cancer pathway | Integrated breast cancer pathway | 2 | 0.013029 | 67 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0030405 | Pancreatic endocrine tumor | A neuroendocrine tumor originating in a hormone-producing cell (islet cell) of the pancreas. | 2 | 0.002825 | 67 |
| HP | HP:0009594 | Retinal hamartoma | A hamartoma (a benign, focal malformation consisting of a disorganized mixture of cells and tissues) of the retina. | 2 | 0.007607 | 67 |
| HP | HP:0002666 | Pheochromocytoma | Pheochromocytomas (also known as chromaffin tumors) produce, store, and secrete catecholamines. Pheochromocytomas usually originate from the adrenal medulla but may also develop from chromaffin cells in or about sympathetic ganglia. A common symptom of pheochromocytoma is hypertension owing to release of catecholamines. | 2 | 0.013692 | 67 |
| HP | HP:0030670 | Hamartoma of the orbital region | A hamartoma (disordered proliferation of mature tissues) which can originate from any tissue of the orbital region. | 2 | 0.015757 | 67 |
| HP | HP:0010568 | Hamartoma of the eye | A hamartoma (disordered proliferation of mature tissues) which can originate from any tissue of the eye. | 2 | 0.015757 | 67 |
| HP | HP:0100634 | Neuroendocrine neoplasm | A tumor that originates from a neuroendocrine cell. | 2 | 0.025464 | 67 |
| HP | HP:0100012 | Neoplasm of the eye | A tumor (abnormal growth of tissue) of the eye. | 2 | 0.042597 | 67 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-8854214 | TBC/RABGAPs | TBC/RABGAPs | 2 | 0.008564 | 67 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008047 | enzyme activator activity | "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 3 | 0.009134 | 67 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04115 | p53 signaling pathway | p53 signaling pathway | 2 | 0.011084 | 67 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 2 | 0.029195 | 67 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | Thyroid hormone signaling pathway | 2 | 0.029683 | 67 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 2 | 0.048665 | 67 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097131 | cyclin D1-CDK6 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 1 | 0.049978 | 67 |
| GO:CC | GO:0097128 | cyclin D1-CDK4 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 1 | 0.049978 | 67 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5287 | CCND1-CDK4 complex | CCND1-CDK4 complex | 1 | 0.049988 | 67 |
| CORUM | CORUM:3084 | CCND1-CDK4 complex | CCND1-CDK4 complex | 1 | 0.049988 | 67 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030126 | COPI vesicle coat | "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894] | 2 | 0.000176 | 68 |
| GO:CC | GO:0030663 | COPI-coated vesicle membrane | "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah] | 2 | 0.000345 | 68 |
| GO:CC | GO:0030137 | COPI-coated vesicle | "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894] | 2 | 0.000677 | 68 |
| GO:CC | GO:0030660 | Golgi-associated vesicle membrane | "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] | 2 | 0.003724 | 68 |
| GO:CC | GO:0030120 | vesicle coat | "A membrane coat found on a coated vesicle." [GOC:mah] | 2 | 0.004399 | 68 |
| GO:CC | GO:0005798 | Golgi-associated vesicle | "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] | 2 | 0.010261 | 68 |
| GO:CC | GO:0030117 | membrane coat | "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] | 2 | 0.010915 | 68 |
| GO:CC | GO:0048475 | coated membrane | "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid] | 2 | 0.010915 | 68 |
| GO:CC | GO:0030662 | coated vesicle membrane | "The lipid bilayer surrounding a coated vesicle." [GOC:mah] | 2 | 0.044640 | 68 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051645 | Golgi localization | "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] | 2 | 0.000617 | 68 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | COPI-dependent Golgi-to-ER retrograde traffic | 2 | 0.043769 | 68 |
| REAC | REAC:R-HSA-6807878 | COPI-mediated anterograde transport | COPI-mediated anterograde transport | 2 | 0.046467 | 68 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6770 | TBX20-TLE3 repressor complex | TBX20-TLE3 repressor complex | 1 | 0.049932 | 68 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5360 | AGO2-FXR1-TNF(alpha)ARE-RNP complex | AGO2-FXR1-TNF(alpha)ARE-RNP complex | 1 | 0.049932 | 69 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4518 | Gamma glutamyl cycle for the biosynthesis and degradation of glutathione including diseases | Gamma glutamyl cycle for the biosynthesis and degradation of glutathione including diseases | 1 | 0.037462 | 70 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003921 | GMP synthase activity | "Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+." [RHEA:18301] | 1 | 0.049724 | 70 |
| GO:MF | GO:0003922 | GMP synthase (glutamine-hydrolyzing) activity | "Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+." [RHEA:11680] | 1 | 0.049724 | 70 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0005978 | glycogen biosynthetic process | "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] | 2 | 0.002128 | 71 |
| GO:BP | GO:0009250 | glucan biosynthetic process | "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] | 2 | 0.002128 | 71 |
| GO:BP | GO:0000271 | polysaccharide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] | 2 | 0.003499 | 71 |
| GO:BP | GO:0005977 | glycogen metabolic process | "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] | 2 | 0.008214 | 71 |
| GO:BP | GO:0044042 | glucan metabolic process | "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl] | 2 | 0.008612 | 71 |
| GO:BP | GO:0006112 | energy reserve metabolic process | "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] | 2 | 0.011200 | 71 |
| GO:BP | GO:0005976 | polysaccharide metabolic process | "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684] | 2 | 0.012137 | 71 |
| GO:BP | GO:0016051 | carbohydrate biosynthetic process | "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 2 | 0.043206 | 71 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5224 | 2q37 copy number variation syndrome | 2q37 copy number variation syndrome | 2 | 0.011366 | 71 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | Glycogen storage disease type 0 (muscle GYS1) | 1 | 0.024966 | 71 |
| REAC | REAC:R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | Glycogen storage disease type XV (GYG1) | 1 | 0.024966 | 71 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:57 | HDAC4-ERK2 complex | HDAC4-ERK2 complex | 1 | 0.024966 | 74 |
| CORUM | CORUM:1 | BCL6-HDAC4 complex | BCL6-HDAC4 complex | 1 | 0.049932 | 74 |
| CORUM | CORUM:55 | HDAC4-ERK1 complex | HDAC4-ERK1 complex | 1 | 0.049932 | 74 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006065 | UDP-glucuronate biosynthetic process | "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] | 1 | 0.049542 | 74 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003979 | UDP-glucose 6-dehydrogenase activity | "Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23596] | 1 | 0.049891 | 74 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP1403 | AMP activated protein kinase signaling | AMP activated protein kinase signaling | 2 | 0.00251 | 76 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0010883 | regulation of lipid storage | "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] | 2 | 0.003004 | 76 |
| GO:BP | GO:0170062 | nutrient storage | "The accumulation and maintenance in cells or tissues of a nutrient, a substance that is used by an organism to survive, to grow, and to reproduce; such as proteins, vitamins, and minerals. Nutrient reserves can be accumulated for mobilization and utilization when needed." [GOC:ew] | 2 | 0.010080 | 76 |
| GO:BP | GO:0019915 | lipid storage | "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] | 2 | 0.010080 | 76 |
| GO:BP | GO:0019217 | regulation of fatty acid metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] | 2 | 0.010300 | 76 |
| GO:BP | GO:0045833 | negative regulation of lipid metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] | 2 | 0.011664 | 76 |
| GO:BP | GO:0010565 | regulation of ketone metabolic process | "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] | 2 | 0.018853 | 76 |
| GO:BP | GO:0007584 | response to nutrient | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] | 2 | 0.034249 | 76 |
| GO:BP | GO:0090459 | intracellular aspartate homeostasis | "A homeostatic process involved in the maintenance of a steady state level of aspartate within a cell." [GOC:tb] | 1 | 0.049542 | 76 |
| GO:BP | GO:0046722 | lactic acid secretion | "The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue." [GOC:ai] | 1 | 0.049542 | 76 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 2 | 0.004248 | 76 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 2 | 0.005249 | 76 |
| KEGG | KEGG:04910 | Insulin signaling pathway | Insulin signaling pathway | 2 | 0.006849 | 76 |
| KEGG | KEGG:04936 | Alcoholic liver disease | Alcoholic liver disease | 2 | 0.007360 | 76 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7403 | SREBP-1a-PKM2 complex | SREBP-1a-PKM2 complex | 1 | 0.024966 | 76 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034418 | Erythematous oral mucosa | An erythematous lesion of the oral mucosa may result from a variety of tissue alterations, including inflammation, erythrocyte extravasation, and atrophy or reduced keratinization of the surface epithelium. | 1 | 0.049962 | 76 |
| HP | HP:0006552 | Fibrocystic lung disease | Fibrocystic lung disease | 1 | 0.049962 | 76 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M01830 | Factor: MAX; motif: CNNGMCACGTGN | Factor: MAX; motif: CNNGMCACGTGN | 2 | 0.013526 | 77 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6078 | HSPA2-ACR-PDIA6 complex | HSPA2-ACR-PDIA6 complex | 1 | 0.049932 | 78 |
| CORUM | CORUM:6079 | BAG6-HSPA2 complex | BAG6-HSPA2 complex | 1 | 0.049932 | 78 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2541 | HGF-Met complex | HGF-Met complex | 1 | 0.024966 | 79 |
| CORUM | CORUM:6798 | S1PR1-c-Met-ITGB4 complex, HGF- or S1P-induced | S1PR1-c-Met-ITGB4 complex, HGF- or S1P-induced | 1 | 0.049932 | 79 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0005008 | hepatocyte growth factor receptor activity | "Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] | 1 | 0.049891 | 79 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0071757 | hexameric IgM immunoglobulin complex | "A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268] | 1 | 0.020616 | 80 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1703 | IGHM-VPREB1-IGLL1 complex | IGHM-VPREB1-IGLL1 complex | 1 | 0.024966 | 80 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 2 | 0.049008 | 81 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2123 | IKBKG homodimer complex | IKBKG homodimer complex | 1 | 0.049932 | 81 |
| CORUM | CORUM:5730 | IKBKG homotrimer complex | IKBKG homotrimer complex | 1 | 0.049932 | 81 |
| CORUM | CORUM:5827 | IKBKG homotetramer complex | IKBKG homotetramer complex | 1 | 0.049932 | 81 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0040042 | Aplasia of the eccrine sweat glands | Aplasia of the eccrine sweat glands | 1 | 0.049962 | 81 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04211 | Longevity regulating pathway | Longevity regulating pathway | 2 | 0.002879 | 83 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | Glucagon signaling pathway | 2 | 0.004169 | 83 |
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 2 | 0.004248 | 83 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 2 | 0.005249 | 83 |
| KEGG | KEGG:04714 | Thermogenesis | Thermogenesis | 2 | 0.019700 | 83 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 2 | 0.034083 | 83 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4321 | Thermogenesis | Thermogenesis | 2 | 0.00656 | 83 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP615 | Senescence and autophagy in cancer | Senescence and autophagy in cancer | 2 | 0.006199 | 84 |
| WP | WP:WP3938 | miR 222 in exercise induced cardiac growth | miR 222 in exercise induced cardiac growth | 1 | 0.039736 | 84 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1656 | p27-cyclinE-CDK2 complex | p27-cyclinE-CDK2 complex | 1 | 0.024966 | 84 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 2 | 0.039909 | 84 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0019914 | cyclin-dependent protein kinase activating kinase regulator activity | "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai] | 1 | 0.049891 | 84 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-190a-5p | hsa-mir-190a-5p | hsa-mir-190a-5p | 2 | 0.001815 | 86 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016231 | beta-N-acetylglucosaminidase activity | "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [PMID:29143882, PMID:37590576] | 1 | 0.049891 | 88 |
| GO:MF | GO:0102571 | [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity | "Catalysis of the reaction: 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl/L-threonyl-[protein] + H2O = L-seryl//L-threonyl-[protein] + N-acetyl-D-glucosamine." [EC:3.2.1.169] | 1 | 0.049891 | 88 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-8073 | hsa-mir-8073 | hsa-mir-8073 | 2 | 0.006704 | 89 |
| MIRNA | MIRNA:hsa-mir-221-5p | hsa-mir-221-5p | hsa-mir-221-5p | 2 | 0.007710 | 89 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6159 | LPP-PPP2CA-PPP2R3A complex | LPP-PPP2CA-PPP2R3A complex | 1 | 0.049932 | 89 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5442 | Wnt Beta catenin signaling inhibitors in current and past clinical trials | Wnt Beta catenin signaling inhibitors in current and past clinical trials | 1 | 0.031218 | 90 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7289 | ANGPTL4-LRP6-SDC2 complex | ANGPTL4-LRP6-SDC2 complex | 1 | 0.049932 | 90 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05563_1 | Factor: ZNF691; motif: NGGTCCGGCGGM; match class: 1 | Factor: ZNF691; motif: NGGTCCGGCGGM; match class: 1 | 1 | 0.049771 | 91 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002832 | negative regulation of response to biotic stimulus | "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] | 2 | 0.017107 | 92 |
| GO:BP | GO:2000308 | negative regulation of tumor necrosis factor (ligand) superfamily member 11 production | "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah] | 1 | 0.049542 | 92 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008832 | dGTPase activity | "Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate." [RHEA:15193] | 1 | 0.049891 | 92 |
| GO:MF | GO:0016793 | triphosphoric monoester hydrolase activity | "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [EC:3.1.5.-] | 1 | 0.049891 | 92 |
| GO:MF | GO:0032560 | guanyl deoxyribonucleotide binding | "Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] | 1 | 0.049891 | 92 |
| GO:MF | GO:0032567 | dGTP binding | "Binding to dGTP, deoxyguanosine triphosphate." [GOC:mah] | 1 | 0.049891 | 92 |
| GO:MF | GO:0106375 | deoxynucleoside triphosphate hydrolase activity | "Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate." [RHEA:46148] | 1 | 0.049891 | 92 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6817-3p | hsa-mir-6817-3p | hsa-mir-6817-3p | 2 | 0.049908 | 92 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6824 | CP-LF complex | CP-LF complex | 1 | 0.049932 | 92 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1222499 | Latent infection - Other responses of Mtb to phagocytosis | Latent infection - Other responses of Mtb to phagocytosis | 1 | 0.049932 | 92 |
| REAC | REAC:R-HSA-1222449 | Mtb iron assimilation by chelation | Mtb iron assimilation by chelation | 1 | 0.049932 | 92 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:6000263 | Papillary dermal edema | Swelling due to fluid acculuation of the papillary dermis. | 1 | 0.049962 | 92 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1901187 | regulation of ephrin receptor signaling pathway | "Any process that modulates the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie] | 1 | 0.049542 | 98 |
| GO:BP | GO:1901189 | positive regulation of ephrin receptor signaling pathway | "Any process that activates or increases the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie] | 1 | 0.049542 | 98 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2907 | RBP-Jkappa-Notch1 complex | RBP-Jkappa-Notch1 complex | 1 | 0.049932 | 98 |
| CORUM | CORUM:2908 | RBP-Jkappa-SHARP complex | RBP-Jkappa-SHARP complex | 1 | 0.049932 | 98 |
| CORUM | CORUM:2946 | YY1-Notch1-RBP-Jkappa complex | YY1-Notch1-RBP-Jkappa complex | 1 | 0.049932 | 98 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:rno-mir-203a-3p | rno-mir-203a-3p | rno-mir-203a-3p | 1 | 0.018269 | 99 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0071142 | homomeric SMAD protein complex | "A protein complex composed of a single type of SMAD family proteins. In the absence of Smad4, phosphorylation of R-SMADs results in their homotrimerization. However, these complexes do not appear to import into the nucleus and are assumed to be transcriptionally inactive." [GOC:bhm, GOC:mah, PMID:11779505, PMID:16322555, PMID:9670020] | 1 | 0.041231 | 99 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2642 | SMAD1-P300 complex | SMAD1-P300 complex | 1 | 0.049932 | 99 |
| CORUM | CORUM:2958 | SMAD1-CBP complex | SMAD1-CBP complex | 1 | 0.049932 | 99 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990026 | hippocampal mossy fiber expansion | "Synaptic expansion of hippocampal mossy fiber axon that makes contact with the thorny excrescences of hippocampal CA3 pyramidal cell dendrites." [NIF_Subcellular:nlx_subcell_1005002] | 1 | 0.041231 | 101 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902350 | cellular response to chloroquine | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869] | 1 | 0.049542 | 101 |
| GO:BP | GO:1905298 | regulation of intestinal epithelial cell development | "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] | 1 | 0.049542 | 101 |
| GO:BP | GO:1905300 | positive regulation of intestinal epithelial cell development | "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] | 1 | 0.049542 | 101 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0042744 | hydrogen peroxide catabolic process | "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl] | 2 | 0.001096 | 104 |
| GO:BP | GO:0042743 | hydrogen peroxide metabolic process | "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, PMID:21734470] | 2 | 0.003499 | 104 |
| GO:BP | GO:0098869 | cellular oxidant detoxification | "Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide." [GOC:dos, GOC:vw] | 2 | 0.010745 | 104 |
| GO:BP | GO:1990748 | cellular detoxification | "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw] | 2 | 0.017392 | 104 |
| GO:BP | GO:0097237 | cellular response to toxic substance | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:pr] | 2 | 0.020373 | 104 |
| GO:BP | GO:0034614 | cellular response to reactive oxygen species | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] | 2 | 0.025286 | 104 |
| GO:BP | GO:0098754 | detoxification | "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos] | 2 | 0.025981 | 104 |
| GO:BP | GO:0000302 | response to reactive oxygen species | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] | 2 | 0.046422 | 104 |
| GO:BP | GO:0002148 | hypochlorous acid metabolic process | "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150] | 1 | 0.049542 | 104 |
| GO:BP | GO:0072722 | response to amitrole | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus." [GOC:mah] | 1 | 0.049542 | 104 |
| GO:BP | GO:0002149 | hypochlorous acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150] | 1 | 0.049542 | 104 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP176 | Folate metabolism | Folate metabolism | 2 | 0.002664 | 104 |
| WP | WP:WP15 | Selenium micronutrient network | Selenium micronutrient network | 2 | 0.004150 | 104 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004601 | peroxidase activity | "Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators] | 2 | 0.003933 | 104 |
| GO:MF | GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [EC:1.11.-.-] | 2 | 0.004217 | 104 |
| GO:MF | GO:0016209 | antioxidant activity | "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] | 2 | 0.008798 | 104 |
| GO:MF | GO:0020037 | heme binding | "Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai] | 2 | 0.025373 | 104 |
| GO:MF | GO:0046906 | tetrapyrrole binding | "Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [GOC:curators, ISBN:0198506732] | 2 | 0.029033 | 104 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0062151 | catalase complex | "A protein-containing complex that is capable of catalase activity." [GOC:bhm, PMID:10656833] | 1 | 0.020616 | 104 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 2 | 0.048406 | 104 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 2 | 0.049918 | 104 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6825 | CP-MPO complex | CP-MPO complex | 1 | 0.049932 | 104 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6254 | GPC-4.1R-p55 complex | GPC-4.1R-p55 complex | 1 | 0.049932 | 105 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0411263 | Retina; outer plexiform layer[High] | Retina; outer plexiform layer[High] | 1 | 0.049944 | 105 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:825 | JBP1-pICln complex | JBP1-pICln complex | 1 | 0.049932 | 106 |
| CORUM | CORUM:836 | 20S methyltransferase core complex | 20S methyltransferase core complex | 1 | 0.049932 | 106 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 2 | 0.048406 | 108 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 2 | 0.049918 | 108 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05473_1 | Factor: DRRS; motif: NTTTTCNATTGA; match class: 1 | Factor: DRRS; motif: NTTTTCNATTGA; match class: 1 | 1 | 0.049771 | 108 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005788 | endoplasmic reticulum lumen | "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] | 2 | 0.04545 | 111 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0006916 | Intraaxonal accumulation of curvilinear autofluorescent lipopigment storage material | Curvilinear intracellular accumulation of autofluorescent lipopigment storage material within axons. | 1 | 0.049962 | 112 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-5093 | hsa-mir-5093 | hsa-mir-5093 | 2 | 0.005435 | 113 |
| MIRNA | MIRNA:hsa-mir-5582-3p | hsa-mir-5582-3p | hsa-mir-5582-3p | 2 | 0.027671 | 113 |
| MIRNA | MIRNA:hsa-mir-548ah-3p | hsa-mir-548ah-3p | hsa-mir-548ah-3p | 2 | 0.036122 | 113 |
| MIRNA | MIRNA:hsa-mir-548am-3p | hsa-mir-548am-3p | hsa-mir-548am-3p | 2 | 0.036122 | 113 |
| MIRNA | MIRNA:hsa-mir-548j-3p | hsa-mir-548j-3p | hsa-mir-548j-3p | 2 | 0.036404 | 113 |
| MIRNA | MIRNA:hsa-mir-548x-3p | hsa-mir-548x-3p | hsa-mir-548x-3p | 2 | 0.036972 | 113 |
| MIRNA | MIRNA:hsa-mir-548ae-3p | hsa-mir-548ae-3p | hsa-mir-548ae-3p | 2 | 0.036972 | 113 |
| MIRNA | MIRNA:hsa-mir-548aq-3p | hsa-mir-548aq-3p | hsa-mir-548aq-3p | 2 | 0.036972 | 113 |
| MIRNA | MIRNA:hsa-mir-548aj-3p | hsa-mir-548aj-3p | hsa-mir-548aj-3p | 2 | 0.036972 | 113 |
| MIRNA | MIRNA:hsa-mir-335-3p | hsa-mir-335-3p | hsa-mir-335-3p | 2 | 0.044127 | 113 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0034147 | regulation of toll-like receptor 5 signaling pathway | "Any process that modulates the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] | 1 | 0.049542 | 113 |
| GO:BP | GO:0034148 | negative regulation of toll-like receptor 5 signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] | 1 | 0.049542 | 113 |
| GO:BP | GO:0070429 | negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add] | 1 | 0.049542 | 113 |
| GO:BP | GO:0072356 | chromosome passenger complex localization to kinetochore | "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis." [GOC:mah] | 1 | 0.049542 | 113 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2018 | RANKL RANK signaling | RANKL RANK signaling | 2 | 0.001391 | 114 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04380 | Osteoclast differentiation | Osteoclast differentiation | 2 | 0.006356 | 114 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 2 | 0.017389 | 114 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4671-5p | hsa-mir-4671-5p | hsa-mir-4671-5p | 2 | 0.013793 | 116 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0032996 | Bcl3-Bcl10 complex | "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus." [PMID:16280327] | 1 | 0.020616 | 116 |
| GO:CC | GO:0033257 | Bcl3/NF-kappaB2 complex | "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099] | 1 | 0.041231 | 116 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4342 | Vitamins A and D action mechanisms | Vitamins A and D action mechanisms | 1 | 0.029803 | 116 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2947 | YY1-Notch1 complex | YY1-Notch1 complex | 1 | 0.024966 | 117 |
| CORUM | CORUM:2907 | RBP-Jkappa-Notch1 complex | RBP-Jkappa-Notch1 complex | 1 | 0.049932 | 117 |
| CORUM | CORUM:2946 | YY1-Notch1-RBP-Jkappa complex | YY1-Notch1-RBP-Jkappa complex | 1 | 0.049932 | 117 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0003178 | coronary sinus valve development | "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart] | 1 | 0.049542 | 117 |
| GO:BP | GO:0003182 | coronary sinus valve morphogenesis | "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart] | 1 | 0.049542 | 117 |
| GO:BP | GO:0003270 | Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation | "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] | 1 | 0.049542 | 117 |
| GO:BP | GO:0060843 | venous endothelial cell differentiation | "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb] | 1 | 0.049542 | 117 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | FBXW7 Mutants and NOTCH1 in Cancer | 1 | 0.049932 | 117 |
| REAC | REAC:R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 1 | 0.049932 | 117 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0025107 | Cutis marmorata telangiectatica congenita | A congenital vascular malformation that presents as localized or generalized erythematous-telangiectatic lesions with a reticular pattern; the lesions are almost always present at birth or develop in the first days of life. Cutis marmorata telangiectatica congenita (CMTC) appears as marble-like pattern (mottling) on the surface of the skin. In contrast to cutis marmorata, the marbling is more severe and always visible. | 1 | 0.049962 | 117 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3634 | Insulin signaling in adipocytes normal condition | Insulin signaling in adipocytes normal condition | 1 | 0.04995 | 118 |
| WP | WP:WP3635 | Insulin signaling in adipocytes diabetic condition | Insulin signaling in adipocytes diabetic condition | 1 | 0.04995 | 118 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1903754 | cortical microtubule plus-end | "The plus-end of a cortical microtubule." [GO_REF:0000064, GOC:TermGenie, GOC:vw] | 1 | 0.041231 | 119 |
| GO:CC | GO:1904511 | cytoplasmic microtubule plus-end | "Any microtubule plus-end that is part of a cytoplasmic microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:15772152] | 1 | 0.041231 | 119 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032219 | Increased proportion of CD4-positive T cells | Abnormal increase of helper CD3+CD4+ T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population. | 1 | 0.049962 | 119 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0320873 | Nasopharynx; ciliated cells (ciliary rootlets)[High] | Nasopharynx; ciliated cells (ciliary rootlets)[High] | 2 | 0.013108 | 120 |
| HPA | HPA:0210873 | Fallopian tube; ciliated cells (ciliary rootlets)[High] | Fallopian tube; ciliated cells (ciliary rootlets)[High] | 2 | 0.033208 | 120 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-196a-5p | hsa-mir-196a-5p | hsa-mir-196a-5p | 2 | 0.044752 | 121 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:4000039 | Reduced mucosal-associated invariant T cell proportion | A decreased proportion of circulating mucosal-associated invariant T (MAIT) cells relative to total T cell count. | 1 | 0.049962 | 121 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0048306 | calcium-dependent protein binding | "Binding to a protein or protein complex in the presence of calcium." [GOC:jid, PMID:10485905] | 2 | 0.007593 | 122 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 2 | 0.033450 | 124 |
| GO:BP | GO:0009443 | pyridoxal 5'-phosphate salvage | "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl] | 1 | 0.049542 | 124 |
| GO:BP | GO:0042817 | pyridoxal metabolic process | "The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, PMID:21767669] | 1 | 0.049542 | 124 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00750 | Vitamin B6 metabolism | Vitamin B6 metabolism | 1 | 0.037408 | 124 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4315 | Malate aspartate shuttle | Malate aspartate shuttle | 1 | 0.039736 | 124 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008478 | pyridoxal kinase activity | "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35] | 1 | 0.049891 | 124 |
| GO:MF | GO:0047860 | diiodophenylpyruvate reductase activity | "Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H+ + NADH." [EC:1.1.1.96, RHEA:20293] | 1 | 0.049891 | 124 |
| GO:MF | GO:0047995 | hydroxyphenylpyruvate reductase activity | "Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH." [RHEA:10780] | 1 | 0.049891 | 124 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0035264 | multicellular organism growth | "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] | 2 | 0.029973 | 126 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097444 | spine apparatus | "A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum." [NIF_Subcellular:sao725931194, PMID:20400711, PMID:8987748] | 1 | 0.039955 | 127 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-10b-5p | hsa-mir-10b-5p | hsa-mir-10b-5p | 2 | 0.043816 | 128 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0033140 | Blake's pouch cyst | The presence of an upwardly displaced normal cerebellar vermis, normal appearance of the fastigium, tentorium and size of the cisterna magna. | 1 | 0.049962 | 128 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5658442 | Regulation of RAS by GAPs | Regulation of RAS by GAPs | 2 | 0.010034 | 132 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0044301 | climbing fiber | "The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber." [NIF_Subcellular:nlx_subcell_20090203] | 1 | 0.041231 | 132 |
| GO:CC | GO:1990032 | parallel fiber | "A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium." [ISBN:0195159551, NIF_Subcellular:nlx_330] | 1 | 0.041231 | 132 |
| GO:CC | GO:1990597 | AIP1-IRE1 complex | "A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein)." [GOC:bf, GOC:PARL, PMID:18281285] | 1 | 0.041231 | 132 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043087 | regulation of GTPase activity | "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] | 2 | 0.047836 | 132 |
| GO:BP | GO:2000257 | regulation of protein activation cascade | "Any process that modulates the frequency, rate or extent of protein activation cascade." [GOC:mah] | 1 | 0.049542 | 132 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030426 | growth cone | "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] | 2 | 0.013058 | 134 |
| GO:CC | GO:0030427 | site of polarized growth | "Any part of a cell where non-isotropic growth takes place." [GOC:mah] | 2 | 0.013849 | 134 |
| GO:CC | GO:0150034 | distal axon | "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] | 2 | 0.036619 | 134 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 2 | 0.049918 | 134 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008013 | beta-catenin binding | "Binding to a catenin beta subunit." [GOC:bf] | 2 | 0.014239 | 134 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1904797 | negative regulation of core promoter binding | "Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] | 1 | 0.049542 | 134 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000502 | proteasome complex | "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome] | 2 | 0.002058 | 136 |
| GO:CC | GO:1905369 | endopeptidase complex | "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 2 | 0.004701 | 136 |
| GO:CC | GO:1905368 | peptidase complex | "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 2 | 0.007805 | 136 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-668-5p | hsa-mir-668-5p | hsa-mir-668-5p | 1 | 0.040671 | 139 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000938 | GARP complex | "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664] | 1 | 0.049943 | 139 |
| GO:CC | GO:1990745 | EARP complex | "A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061] | 1 | 0.049943 | 139 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:mir-370 | mir-370 | mir-370 | 1 | 0.018269 | 140 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0060785 | regulation of apoptosis involved in tissue homeostasis | "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue." [GOC:dph] | 1 | 0.049542 | 141 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6292 | HAX-1-XIAP complex | HAX-1-XIAP complex | 1 | 0.049932 | 141 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034799 | Splenic hemophagocytosis | Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the spleen. | 1 | 0.049962 | 141 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990622 | CHOP-ATF3 complex | "A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits." [GOC:bf, GOC:PARL, PMID:8622660] | 1 | 0.041231 | 142 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway | "Any process that activates or increases the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24939851] | 1 | 0.049542 | 142 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6092 | c-Jun-ATF3 complex | c-Jun-ATF3 complex | 1 | 0.049932 | 142 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005498 | Midline skin dimples over anterior/posterior fontanelles | Midline skin dimples over anterior/posterior fontanelles | 1 | 0.049962 | 142 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3046 | hs4 enhancer complex (slow migrating complex) | hs4 enhancer complex (slow migrating complex) | 1 | 0.049932 | 143 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP690 | Polyol pathway | Polyol pathway | 1 | 0.039736 | 144 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0043795 | glyceraldehyde oxidoreductase activity | "Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H+." [PMID:10095793, RHEA:36047] | 1 | 0.049891 | 144 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:933 | SCRIB-APC complex | SCRIB-APC complex | 1 | 0.024966 | 146 |
| CORUM | CORUM:926 | SCRIB-LGL2 complex | SCRIB-LGL2 complex | 1 | 0.049932 | 146 |
| CORUM | CORUM:928 | SCRIB-VANGL2 complex | SCRIB-VANGL2 complex | 1 | 0.049932 | 146 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0034750 | Scrib-APC-beta-catenin complex | "A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation." [PMID:16611247] | 1 | 0.041231 | 146 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471402 | Skin 2; cells in corneal layer[≥Medium] | Skin 2; cells in corneal layer[≥Medium] | 2 | 0.004342 | 147 |
| HPA | HPA:0471401 | Skin 2; cells in corneal layer[≥Low] | Skin 2; cells in corneal layer[≥Low] | 2 | 0.010249 | 147 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 2 | 0.033208 | 147 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 2 | 0.033208 | 147 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990660 | calprotectin complex | "A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways." [GOC:bhm, PMID:25417112] | 1 | 0.041231 | 147 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6826 | Calprotectin heterotetramer | Calprotectin heterotetramer | 1 | 0.049932 | 147 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031467 | Cul7-RING ubiquitin ligase complex | "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein." [PMID:15571813, PMID:15688063] | 1 | 0.039955 | 148 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | FBXW7 Mutants and NOTCH1 in Cancer | 1 | 0.049932 | 148 |
| REAC | REAC:R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 1 | 0.049932 | 148 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1990547 | mitochondrial phosphate ion transmembrane transport | "The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9099701] | 1 | 0.049542 | 149 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0015317 | phosphate:proton symporter activity | "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-] | 1 | 0.049891 | 149 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902612 | regulation of anti-Mullerian hormone signaling pathway | "Any process that modulates the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077] | 1 | 0.049542 | 150 |
| GO:BP | GO:1902613 | negative regulation of anti-Mullerian hormone signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077] | 1 | 0.049542 | 150 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0010790 | Hypoplasia of the Leydig cells | Underdevelopment of the interstitial (Leydig) cells of the testis. These cells produce testosterone. | 1 | 0.049962 | 150 |
| HP | HP:0012860 | Testicular fibrosis | Formation of excess connective tissue in the testicle. | 1 | 0.049962 | 150 |
| HP | HP:0025496 | Abnormal coronary artery physiology | Any anomaly of the function of a coronary artery. | 1 | 0.049962 | 150 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | Regulation of Expression and Function of Type II Classical Cadherins | 2 | 0.001974 | 152 |
| REAC | REAC:R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | Regulation of Homotypic Cell-Cell Adhesion | 2 | 0.001974 | 152 |
| REAC | REAC:R-HSA-418990 | Adherens junctions interactions | Adherens junctions interactions | 2 | 0.006739 | 152 |
| REAC | REAC:R-HSA-421270 | Cell-cell junction organization | Cell-cell junction organization | 2 | 0.016977 | 152 |
| REAC | REAC:R-HSA-446728 | Cell junction organization | Cell junction organization | 2 | 0.029229 | 152 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1901655 | cellular response to ketone | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie] | 2 | 0.014647 | 152 |
| GO:BP | GO:1904828 | positive regulation of hydrogen sulfide biosynthetic process | "Any process that activates or increases the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] | 1 | 0.049542 | 152 |
| GO:BP | GO:1904568 | cellular response to wortmannin | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20629186] | 1 | 0.049542 | 152 |
| GO:BP | GO:1904567 | response to wortmannin | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20629186] | 1 | 0.049542 | 152 |
| GO:BP | GO:1904826 | regulation of hydrogen sulfide biosynthetic process | "Any process that modulates the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] | 1 | 0.049542 | 152 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0091012 | Cerebellum; molecular layer cells - nucleus[≥Medium] | Cerebellum; molecular layer cells - nucleus[≥Medium] | 2 | 0.015392 | 152 |
| HPA | HPA:0091011 | Cerebellum; molecular layer cells - nucleus[≥Low] | Cerebellum; molecular layer cells - nucleus[≥Low] | 2 | 0.018654 | 152 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5235 | Estradiol regulation in porto sinusoidal vascular disease | Estradiol regulation in porto sinusoidal vascular disease | 1 | 0.049667 | 152 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7326 | HINT1-SP1 complex | HINT1-SP1 complex | 1 | 0.049932 | 152 |
| CORUM | CORUM:2237 | SP1-MCAF2 complex | SP1-MCAF2 complex | 1 | 0.049932 | 152 |
| CORUM | CORUM:2679 | p53-SP1 complex | p53-SP1 complex | 1 | 0.049932 | 152 |
| CORUM | CORUM:6067 | ESR1-SP1 complex | ESR1-SP1 complex | 1 | 0.049932 | 152 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M04614_1 | Factor: Ipf1; motif: NNNNTAATKR; match class: 1 | Factor: Ipf1; motif: NNNNTAATKR; match class: 1 | 2 | 0.031907 | 153 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 1 | 0.037449 | 154 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0009328 | phenylalanine-tRNA ligase complex | "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [PMID:20223217] | 1 | 0.019977 | 155 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3595 | mir 124 predicted interactions with cell cycle and differentiation | mir 124 predicted interactions with cell cycle and differentiation | 1 | 0.037462 | 157 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0035375 | zymogen binding | "Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis." [ISBN:0198506732] | 1 | 0.049891 | 157 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008204 | Precocious puberty with Sertoli cell tumor | Precocious puberty with Sertoli cell tumor | 1 | 0.049962 | 157 |
| HP | HP:0031261 | Bladder polyp | An abnormal growth that projects from the mucous membrane of the urinary bladder. | 1 | 0.049962 | 157 |
| HP | HP:0032451 | Oral melanotic macule | Flat, distinct, discolored area of oral mucosal membrane less than 1 cm wide not associated with a change in the thickness or texture of the affected mucosal membrane. The lesions are small, solitary, well-circumscribed and often uniformly pigmented. | 1 | 0.049962 | 157 |
| HP | HP:0032454 | Labial melanotic macule | Flat, distinct, discolored area on the lip less than 1 cm wide not associated with a change in the thickness or texture. | 1 | 0.049962 | 157 |
| HP | HP:0034352 | Bile duct polyp | An elevated growth from the the mucosa of the bile duct. | 1 | 0.049962 | 157 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002204 | somatic recombination of immunoglobulin genes involved in immune response | "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149] | 2 | 0.003629 | 158 |
| GO:BP | GO:0002208 | somatic diversification of immunoglobulins involved in immune response | "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701] | 2 | 0.003629 | 158 |
| GO:BP | GO:0045190 | isotype switching | "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [ISBN:0781735149] | 2 | 0.003629 | 158 |
| GO:BP | GO:0002381 | immunoglobulin production involved in immunoglobulin-mediated immune response | "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:9185563] | 2 | 0.004171 | 158 |
| GO:BP | GO:0016447 | somatic recombination of immunoglobulin gene segments | "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149] | 2 | 0.004750 | 158 |
| GO:BP | GO:0016445 | somatic diversification of immunoglobulins | "The somatic process that results in the generation of sequence diversity of immunoglobulins." [GOC:add, GOC:ma, ISBN:0781735149] | 2 | 0.005528 | 158 |
| GO:BP | GO:0002562 | somatic diversification of immune receptors via germline recombination within a single locus | "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] | 2 | 0.006192 | 158 |
| GO:BP | GO:0016444 | somatic cell DNA recombination | "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma] | 2 | 0.006192 | 158 |
| GO:BP | GO:0002200 | somatic diversification of immune receptors | "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] | 2 | 0.007260 | 158 |
| GO:BP | GO:0002312 | B cell activation involved in immune response | "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal] | 2 | 0.009649 | 158 |
| GO:BP | GO:0002377 | immunoglobulin production | "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] | 2 | 0.013363 | 158 |
| GO:BP | GO:0002520 | immune system development | "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] | 2 | 0.048312 | 158 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2000158 | positive regulation of ubiquitin-specific protease activity | "Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol] | 1 | 0.049542 | 159 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005437 | Recurrent infections in infancy and early childhood | Recurrent infections at an early age with improvement in later childhood. | 1 | 0.049962 | 160 |
| HP | HP:6000517 | Elevated monolysocardiolipin/cardiolipin ratio | The concentration of monolysocardiolipin related to that of cardiolipin is above the upper limit of normal. This is a functional assay that can be performed from a blood spot to diagnose Barth syndrome (OMIM:302060). | 1 | 0.049962 | 160 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | Deactivation of the beta-catenin transactivating complex | 2 | 0.003907 | 161 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb] | 2 | 0.022274 | 161 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] | 2 | 0.034652 | 161 |
| GO:BP | GO:0060517 | epithelial cell proliferation involved in prostatic bud elongation | "The multiplication of epithelial cells, contributing to the expansion of the primary prostatic bud." [GOC:dph, PMID:18977204] | 1 | 0.049542 | 161 |
| GO:BP | GO:0060784 | regulation of cell proliferation involved in tissue homeostasis | "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." [GOC:dph] | 1 | 0.049542 | 161 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3125 | TLE1 homodimer complex | TLE1 homodimer complex | 1 | 0.024966 | 161 |
| CORUM | CORUM:3127 | TLE-Histone H3 complex | TLE-Histone H3 complex | 1 | 0.024966 | 161 |
| CORUM | CORUM:3120 | OCT1-OBF1-DNA-TLE1 complex | OCT1-OBF1-DNA-TLE1 complex | 1 | 0.049932 | 161 |
| CORUM | CORUM:3124 | TLE1-TLE2 complex | TLE1-TLE2 complex | 1 | 0.049932 | 161 |
| CORUM | CORUM:3150 | NK-3-Groucho complex | NK-3-Groucho complex | 1 | 0.049932 | 161 |
| CORUM | CORUM:3164 | HESX1-TLE1 complex | HESX1-TLE1 complex | 1 | 0.049932 | 161 |
| CORUM | CORUM:6769 | TBX20-TLE1 repressor complex | TBX20-TLE1 repressor complex | 1 | 0.049932 | 161 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0271111 | Kidney; bowman's capsule[≥Low] | Kidney; bowman's capsule[≥Low] | 2 | 0.039082 | 161 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008477 | Poorly ossified cervical vertebrae | Decreased ossification of the cervical vertebral bodies, i.e., of the Cervical vertebrae set. | 1 | 0.049962 | 161 |
| HP | HP:0032538 | Pretibial dimple | A groove or crease on the shins (pretibial, i.e., over the shin bone). Pretibial creases may be obvious at birth and may range from 3 cm to over 15 cm in length and lengthen as the limb grows. They appear as an elongated dimple because of the attachment of skin to underlying tissue (e.g., to the tibia). The dimple or crease grows in proportion to the growth of the leg. | 1 | 0.049962 | 161 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0098957 | anterograde axonal transport of mitochondrion | "The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [GOC:dos] | 2 | 0.000035 | 163 |
| GO:BP | GO:0019896 | axonal transport of mitochondrion | "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai] | 2 | 0.000361 | 163 |
| GO:BP | GO:0048311 | mitochondrion distribution | "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid] | 2 | 0.000403 | 163 |
| GO:BP | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated | "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220] | 2 | 0.000891 | 163 |
| GO:BP | GO:0047497 | mitochondrion transport along microtubule | "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd] | 2 | 0.000891 | 163 |
| GO:BP | GO:0051654 | establishment of mitochondrion localization | "The directed movement of the mitochondrion to a specific location." [GOC:ai] | 2 | 0.001322 | 163 |
| GO:BP | GO:0047496 | vesicle transport along microtubule | "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl] | 2 | 0.002547 | 163 |
| GO:BP | GO:0008089 | anterograde axonal transport | "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194] | 2 | 0.003004 | 163 |
| GO:BP | GO:0051646 | mitochondrion localization | "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] | 2 | 0.003247 | 163 |
| GO:BP | GO:0099518 | vesicle cytoskeletal trafficking | "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl] | 2 | 0.004750 | 163 |
| GO:BP | GO:0098930 | axonal transport | "The directed movement of organelles or molecules along microtubules in axons." [ISBN:0815316194] | 2 | 0.005528 | 163 |
| GO:BP | GO:0008088 | axo-dendritic transport | "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194] | 2 | 0.008019 | 163 |
| GO:BP | GO:0072384 | organelle transport along microtubule | "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] | 2 | 0.009437 | 163 |
| GO:BP | GO:0010970 | transport along microtubule | "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] | 2 | 0.037119 | 163 |
| GO:BP | GO:0051650 | establishment of vesicle localization | "The directed movement of a vesicle to a specific location." [GOC:ai] | 2 | 0.046891 | 163 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:177 | OGT-TRAK1-TRAK2 complex | OGT-TRAK1-TRAK2 complex | 2 | 0.000044 | 163 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9013425 | RHOT1 GTPase cycle | RHOT1 GTPase cycle | 2 | 0.000045 | 163 |
| REAC | REAC:R-HSA-9013419 | RHOT2 GTPase cycle | RHOT2 GTPase cycle | 2 | 0.000095 | 163 |
| REAC | REAC:R-HSA-9715370 | Miro GTPase Cycle | Miro GTPase Cycle | 2 | 0.000127 | 163 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0050811 | GABA receptor binding | "Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai] | 2 | 0.000335 | 163 |
| GO:MF | GO:0017022 | myosin binding | "Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah] | 2 | 0.007023 | 163 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1904115 | axon cytoplasm | "Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152] | 2 | 0.001877 | 163 |
| GO:CC | GO:0120111 | neuron projection cytoplasm | "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha] | 2 | 0.003645 | 163 |
| GO:CC | GO:0032838 | plasma membrane bounded cell projection cytoplasm | "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah] | 2 | 0.035582 | 163 |
| GO:CC | GO:0099568 | cytoplasmic region | "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos] | 2 | 0.045450 | 163 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043393 | regulation of protein binding | "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators] | 2 | 0.015177 | 164 |
| GO:BP | GO:0060377 | negative regulation of mast cell differentiation | "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] | 1 | 0.049542 | 164 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | Ubiquitin mediated proteolysis | 2 | 0.007153 | 166 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0036143 | kringle domain binding | "Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors." [GOC:yaf, Wikipedia:Kringle_domain] | 1 | 0.049891 | 167 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3181 | LMO4-CREB complex | LMO4-CREB complex | 1 | 0.024966 | 170 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004573 | Glc3Man9GlcNAc2 oligosaccharide glucosidase activity | "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106] | 1 | 0.049891 | 171 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4793954 | Defective MOGS causes CDG-2b | Defective MOGS causes CDG-2b | 1 | 0.049932 | 171 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00430 | Taurine and hypotaurine metabolism | Taurine and hypotaurine metabolism | 1 | 0.030715 | 172 |
| KEGG | KEGG:00770 | Pantothenate and CoA biosynthesis | Pantothenate and CoA biosynthesis | 1 | 0.040313 | 172 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0019449 | L-cysteine catabolic process to hypotaurine | "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine." [GOC:go_curators] | 1 | 0.049542 | 172 |
| GO:BP | GO:0019452 | L-cysteine catabolic process to taurine | "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine." [GOC:go_curators] | 1 | 0.049542 | 172 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06394 | Factor: ZNF761; motif: KGGTTGATCGGA | Factor: ZNF761; motif: KGGTTGATCGGA | 1 | 0.049771 | 173 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0100143 | Cerebral cortex; neuronal projections[High] | Cerebral cortex; neuronal projections[High] | 1 | 0.015772 | 175 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0170047 | virus-like capsid | "A protein coat that surrounds nucleic acid to form a structure similar to a virus capsid. Virus-like capsids are non-infectious and are encoded by endogenous (non-viral) genes. Fly and tetrapod Arc (ancestrally-related to retrotransposon Gag) are examples of proteins that can self-assemble into capsid-like structures which encapsulate Arc mRNA and mediate the intercellular transmission of RNA." [PMID:29328916] | 1 | 0.020616 | 175 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 2 | 0.049918 | 175 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05032 | Morphine addiction | Morphine addiction | 2 | 0.002879 | 176 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | Parathyroid hormone synthesis, secretion and action | 2 | 0.004014 | 176 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] | 2 | 0.004602 | 176 |
| GO:BP | GO:0008277 | regulation of G protein-coupled receptor signaling pathway | "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] | 2 | 0.028123 | 176 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP289 | Myometrial relaxation and contraction pathways | Myometrial relaxation and contraction pathways | 2 | 0.013376 | 176 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006530 | asparagine catabolic process | "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] | 1 | 0.049542 | 177 |
| GO:BP | GO:0033345 | asparagine catabolic process via L-aspartate | "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah] | 1 | 0.049542 | 177 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0044858 | plasma membrane raft polarization | "The clustering and aggregation of a plasma membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity." [GOC:jl] | 1 | 0.049542 | 178 |
| GO:BP | GO:1903906 | regulation of plasma membrane raft polarization | "Any process that modulates the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] | 1 | 0.049542 | 178 |
| GO:BP | GO:1905707 | negative regulation of mitochondrial ATP synthesis coupled proton transport | "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport." [GO_REF:0000058, GOC:TermGenie, PMID:12809520, PMID:15294286] | 1 | 0.049542 | 178 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032614 | Renal glomerular amyloid deposition | Amyloid deposits located in the glomeruli in a focal segmental, diffuse segmental or diffuse global fashion. This abnormality can be accompanied by mesangial involvement and in later stages also involvement of the peripheral capillaries. | 1 | 0.049962 | 178 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0030544 | Hsp70 protein binding | "Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732] | 2 | 0.003019 | 179 |
| GO:MF | GO:0031072 | heat shock protein binding | "Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw] | 2 | 0.020984 | 179 |
| GO:MF | GO:0051087 | protein-folding chaperone binding | "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443] | 2 | 0.021960 | 179 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6079 | BAG6-HSPA2 complex | BAG6-HSPA2 complex | 1 | 0.049932 | 179 |
| CORUM | CORUM:6862 | Bag6-Ubl4A-Trc35 Complex | Bag6-Ubl4A-Trc35 Complex | 1 | 0.049932 | 179 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | 2 | 0.000953 | 181 |
| REAC | REAC:R-HSA-8863678 | Neurodegenerative Diseases | Neurodegenerative Diseases | 2 | 0.000953 | 181 |
| REAC | REAC:R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | Defective Intrinsic Pathway for Apoptosis | 2 | 0.001252 | 181 |
| REAC | REAC:R-HSA-9645723 | Diseases of programmed cell death | Diseases of programmed cell death | 2 | 0.023838 | 181 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 2 | 0.038228 | 181 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 2 | 0.039715 | 181 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9734767 | Developmental Cell Lineages | Developmental Cell Lineages | 2 | 0.00354 | 182 |
| REAC | REAC:R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 2 | 0.00354 | 182 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 2 | 0.007057 | 183 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005947 | Decreased sensitivity to hypoxemia | Reduced tendency to respond to a reduced concentration of oxygen in the blood by increasing respiration. | 1 | 0.049962 | 183 |
| HP | HP:6000993 | Pupillary hypersensitivity to parasympathomimetic agents | A higher than normal tendency of parasympathomimetic agents to induce miosis. | 1 | 0.049962 | 183 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0140454 | protein aggregate center assembly | "The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding." [PMID:32075773] | 1 | 0.049542 | 184 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051916 | granulocyte colony-stimulating factor binding | "Binding to granulocyte colony-stimulating factor, G-CSF." [GOC:ai] | 1 | 0.049891 | 184 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008318 | Elevated leukocyte alkaline phosphatase | Increased alkaline phosphatase measured within leukocytes. | 1 | 0.049962 | 184 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-887-3p | hsa-mir-887-3p | hsa-mir-887-3p | 1 | 0.027114 | 186 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3585 | Cytosine methylation | Cytosine methylation | 1 | 0.04995 | 186 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3527 | Pre implantation embryo | Pre implantation embryo | 2 | 0.001877 | 187 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000794 | condensed nuclear chromosome | "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh] | 2 | 0.003091 | 187 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 2 | 0.025593 | 187 |
| GO:CC | GO:0000793 | condensed chromosome | "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] | 2 | 0.037670 | 187 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0001890 | placenta development | "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] | 2 | 0.027041 | 187 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-111446 | Activation of BIM and translocation to mitochondria | Activation of BIM and translocation to mitochondria | 1 | 0.037449 | 189 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0110027 | negative regulation of DNA strand resection involved in replication fork processing | "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing." [GOC:mah, PMID:28475874] | 1 | 0.049542 | 189 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2486 | GIPC1-LHCGR complex | GIPC1-LHCGR complex | 1 | 0.049932 | 191 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070652 | HAUS complex | "A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217] | 2 | 0.000042 | 192 |
| GO:CC | GO:1990498 | mitotic spindle microtubule | "Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw] | 2 | 0.000112 | 192 |
| GO:CC | GO:0005876 | spindle microtubule | "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] | 2 | 0.003168 | 192 |
| GO:CC | GO:0005875 | microtubule associated complex | "Any multimeric complex connected to a microtubule." [GOC:jl] | 2 | 0.011692 | 192 |
| GO:CC | GO:0072686 | mitotic spindle | "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] | 2 | 0.015843 | 192 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0010968 | regulation of microtubule nucleation | "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] | 2 | 0.000403 | 192 |
| GO:BP | GO:0007020 | microtubule nucleation | "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712] | 2 | 0.002439 | 192 |
| GO:BP | GO:0031113 | regulation of microtubule polymerization | "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah] | 2 | 0.004750 | 192 |
| GO:BP | GO:0046785 | microtubule polymerization | "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] | 2 | 0.011200 | 192 |
| GO:BP | GO:0031110 | regulation of microtubule polymerization or depolymerization | "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] | 2 | 0.011200 | 192 |
| GO:BP | GO:0051225 | spindle assembly | "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] | 2 | 0.021631 | 192 |
| GO:BP | GO:0031109 | microtubule polymerization or depolymerization | "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] | 2 | 0.022274 | 192 |
| GO:BP | GO:0007098 | centrosome cycle | "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] | 2 | 0.022927 | 192 |
| GO:BP | GO:0031023 | microtubule organizing center organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] | 2 | 0.027399 | 192 |
| GO:BP | GO:0070507 | regulation of microtubule cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 2 | 0.031495 | 192 |
| GO:BP | GO:0032271 | regulation of protein polymerization | "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 2 | 0.046422 | 192 |
| GO:BP | GO:0007051 | spindle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] | 2 | 0.049754 | 192 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | Loss of proteins required for interphase microtubule organization from the centrosome | 2 | 0.010338 | 192 |
| REAC | REAC:R-HSA-380259 | Loss of Nlp from mitotic centrosomes | Loss of Nlp from mitotic centrosomes | 2 | 0.010338 | 192 |
| REAC | REAC:R-HSA-8854518 | AURKA Activation by TPX2 | AURKA Activation by TPX2 | 2 | 0.011277 | 192 |
| REAC | REAC:R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | Recruitment of mitotic centrosome proteins and complexes | 2 | 0.014340 | 192 |
| REAC | REAC:R-HSA-380287 | Centrosome maturation | Centrosome maturation | 2 | 0.014340 | 192 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 2 | 0.016201 | 192 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 2 | 0.019836 | 192 |
| REAC | REAC:R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | Anchoring of the basal body to the plasma membrane | 2 | 0.020693 | 192 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M04775_1 | Factor: TCF-4; motif: NCTTTGATS; match class: 1 | Factor: TCF-4; motif: NCTTTGATS; match class: 1 | 2 | 0.04448 | 193 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:6000447 | Decreased CSF asialotransferrin to transferrin ratio | The concentration of asialotransferrin relative to that of transferrin in the cerebrospinal fluid (CSF) is below the lower limit of normal. | 1 | 0.049962 | 195 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006383 | transcription by RNA polymerase III | "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659] | 2 | 0.004456 | 196 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0020083 | Furuncle | An infection of a hair follicle that extends subcutaneously, forming an abscess. | 1 | 0.049962 | 196 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04614 | Renin-angiotensin system | Renin-angiotensin system | 1 | 0.044153 | 197 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0098784 | biofilm matrix organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a biofilm matrix." [GOC:mah] | 1 | 0.049542 | 197 |
| GO:BP | GO:0098786 | biofilm matrix disassembly | "A process that results in the disassembly of a biofilm matrix." [GOC:mah] | 1 | 0.049542 | 197 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4818 | Conversion of angiotensinogen to angiotensin II | Conversion of angiotensinogen to angiotensin II | 1 | 0.049667 | 197 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5389 | SERPINA3-CTSG complex | SERPINA3-CTSG complex | 1 | 0.049932 | 197 |
| CORUM | CORUM:5391 | SERPINA1-CTSG complex | SERPINA1-CTSG complex | 1 | 0.049932 | 197 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2001246 | negative regulation of phosphatidylcholine biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol] | 1 | 0.049542 | 199 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047191 | 1-alkylglycerophosphocholine O-acyltransferase activity | "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.63, MetaCyc:2.3.1.63-RXN] | 1 | 0.049891 | 199 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0130893 | Colon; goblet cells[High] | Colon; goblet cells[High] | 2 | 0.022671 | 200 |
| HPA | HPA:0150893 | Duodenum; goblet cells[High] | Duodenum; goblet cells[High] | 2 | 0.023117 | 200 |
| HPA | HPA:0480893 | Small intestine; goblet cells[High] | Small intestine; goblet cells[High] | 2 | 0.023117 | 200 |
| HPA | HPA:0400893 | Rectum; goblet cells[High] | Rectum; goblet cells[High] | 2 | 0.024250 | 200 |
| HPA | HPA:0151341 | Duodenum; glands of Brunner[≥Low] | Duodenum; glands of Brunner[≥Low] | 2 | 0.038214 | 200 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070381 | endosome to plasma membrane transport vesicle | "A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah, PMID:10679016, PMID:12110576] | 1 | 0.041231 | 200 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0097753 | membrane bending | "A membrane organization process resulting in the bending of a membrane." [GOC:krc, GOC:pr, GOC:vw, Wikipedia:Membrane_curvature] | 1 | 0.049542 | 200 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7127 | GSKIP-GSK3B-PRKAR2A complex | GSKIP-GSK3B-PRKAR2A complex | 1 | 0.049932 | 201 |
| CORUM | CORUM:7128 | GSKIP-GSK3B-PRKAR2A complex | GSKIP-GSK3B-PRKAR2A complex | 1 | 0.049932 | 201 |
| CORUM | CORUM:7129 | GSKIP-PRKAR2B complex | GSKIP-PRKAR2B complex | 1 | 0.049932 | 201 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00220 | Arginine biosynthesis | Arginine biosynthesis | 1 | 0.042233 | 202 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0070953 | regulation of neutrophil mediated killing of fungus | "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a fungal cell, the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] | 1 | 0.049542 | 202 |
| GO:BP | GO:0070965 | positive regulation of neutrophil mediated killing of fungus | "Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] | 1 | 0.049542 | 202 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008339 | Diaminoaciduria | An increased urine level of any amino acid carrying two amino groups (Asparagine, glutamine and lysine, cystine, ornithine). | 1 | 0.049962 | 202 |
| HP | HP:4000203 | Reduced erythrocyte arginase activity | Activity or concentration of arginase (EC 3.5.3.1) in red blood cells below the lower limit of normal. Arginase catalyzes the last step of the urea cycle. | 1 | 0.049962 | 202 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-489-5p | hsa-mir-489-5p | hsa-mir-489-5p | 1 | 0.002260 | 204 |
| MIRNA | MIRNA:hsa-mir-6854-3p | hsa-mir-6854-3p | hsa-mir-6854-3p | 1 | 0.038412 | 204 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1903775 | regulation of DNA double-strand break processing | "Any process that modulates the frequency, rate or extent of DNA double-strand break processing." [GO_REF:0000058, GOC:TermGenie, PMID:25203555] | 1 | 0.049542 | 205 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05606_1 | Factor: ZNF691; motif: NAGGCCAGCCGC; match class: 1 | Factor: ZNF691; motif: NAGGCCAGCCGC; match class: 1 | 1 | 0.037328 | 206 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7477 | TANGO1L-cTAGE5-SEC12 complex | TANGO1L-cTAGE5-SEC12 complex | 1 | 0.049932 | 206 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0160129 | protein-DNA covalent cross-linking activity | "Catalysis of the cross-link between a protein and a DNA abasic site, forming a thiazolidine linkage between a DNA ring-opened abasic site and the alpha-amino and sulfhydryl substituents of cysteine residue of the protein." [PMID:30554877, PMID:31235913] | 1 | 0.024946 | 207 |
| GO:MF | GO:0140431 | DNA-(abasic site) binding | "Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base." [PMID:23245849] | 1 | 0.049891 | 207 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-325-3p | hsa-mir-325-3p | hsa-mir-325-3p | 1 | 0.00226 | 208 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0005151 | interleukin-1, type II receptor binding | "Binding to a Type II interleukin-1 receptor." [GOC:ai] | 1 | 0.049891 | 209 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5370 | ERAP1-ERAP2 complex | ERAP1-ERAP2 complex | 1 | 0.049932 | 209 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0033257 | Bcl3/NF-kappaB2 complex | "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099] | 1 | 0.019977 | 210 |
| GO:CC | GO:0033256 | I-kappaB/NF-kappaB complex | "A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm." [GOC:bf, GOC:mah, PMID:9407099] | 1 | 0.039955 | 210 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6362 | PDLIM1-E-cadherin-beta-catenin complex | PDLIM1-E-cadherin-beta-catenin complex | 1 | 0.049932 | 211 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6840-5p | hsa-mir-6840-5p | hsa-mir-6840-5p | 1 | 0.042931 | 217 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3297 | EV release from cardiac cells and their functional effects | EV release from cardiac cells and their functional effects | 1 | 0.043706 | 217 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5609977 | Defective GALE causes EDG | Defective GALE causes EDG | 1 | 0.012483 | 220 |
| REAC | REAC:R-HSA-70370 | Galactose catabolism | Galactose catabolism | 1 | 0.049932 | 220 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity | "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7] | 1 | 0.024946 | 220 |
| GO:MF | GO:0003978 | UDP-glucose 4-epimerase activity | "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] | 1 | 0.024946 | 220 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05890 | Factor: NRIF; motif: NTGGGCAWACGA | Factor: NRIF; motif: NTGGGCAWACGA | 1 | 0.049771 | 220 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3151 | Sulphiredoxin-peroxiredoxin complex | Sulphiredoxin-peroxiredoxin complex | 1 | 0.049932 | 223 |
| CORUM | CORUM:6675 | PI4K2A-PRDX1 complex | PI4K2A-PRDX1 complex | 1 | 0.049932 | 223 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5383 | TRIB3-DDIT3 complex | TRIB3-DDIT3 complex | 1 | 0.049932 | 228 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-165158 | Activation of AKT2 | Activation of AKT2 | 1 | 0.049932 | 228 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070701 | mucus layer | "An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes." [GOC:krc, GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394, Wikipedia:Mucin] | 1 | 0.019977 | 230 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6788-3p | hsa-mir-6788-3p | hsa-mir-6788-3p | 1 | 0.04745 | 234 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005766 | Disproportionate shortening of the tibia | Disproportionate shortening of the tibia | 1 | 0.049962 | 235 |
| HP | HP:0005873 | Polysyndactyly of hallux | Combined syndactyly and polydactyly of the great toe. | 1 | 0.049962 | 235 |
| HP | HP:0009776 | Adactyly | The absence of all phalanges of all the digits of a limb and the associated soft tissues. | 1 | 0.049962 | 235 |
| HP | HP:0010100 | Complete duplication of hallux phalanx | Complete duplication of one or more phalanx of big toe. | 1 | 0.049962 | 235 |
| HP | HP:0410033 | Unilateral alveolar cleft of maxilla | One sided alveolar cleft of the maxilla. | 1 | 0.049962 | 235 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0006346 | Screwdriver-shaped incisors | An abnormality of morphology of the incisor tooth in which the tooth is shaped like a screwdriver blade, i.e., having a rhomboid shape. | 1 | 0.049962 | 236 |
| HP | HP:0011092 | Mulberry molar | Mulberry molars are irregular teeth generally affecting the first molars and are characterized by a grossly deformed crown imitating, as the name implies, the surface of a mulberry. | 1 | 0.049962 | 236 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0032090 | Pyrin domain binding | "Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain." [GOC:rl] | 1 | 0.049891 | 237 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0010992 | Stress urinary incontinence | Involuntary urine leakage synchronous with exertion, or actions such as sneezing, or coughing. | 1 | 0.049962 | 239 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0044611 | nuclear pore inner ring | "A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] | 1 | 0.029966 | 240 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9851151 | MDK and PTN in ALK signaling | MDK and PTN in ALK signaling | 1 | 0.049932 | 241 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11648 | Factor: HSFY1; motif: NCRTTCGAAACGTTCGAWN | Factor: HSFY1; motif: NCRTTCGAAACGTTCGAWN | 1 | 0.024886 | 247 |
| TF | TF:M11649 | Factor: HSFY1; motif: NTTCGAANSNTTCGAAN | Factor: HSFY1; motif: NTTCGAANSNTTCGAAN | 1 | 0.024886 | 247 |
| TF | TF:M11649_1 | Factor: HSFY1; motif: NTTCGAANSNTTCGAAN; match class: 1 | Factor: HSFY1; motif: NTTCGAANSNTTCGAAN; match class: 1 | 1 | 0.024886 | 247 |
| TF | TF:M11652 | Factor: HSFY1; motif: NCRTTCGAAACGTTCGAWN | Factor: HSFY1; motif: NCRTTCGAAACGTTCGAWN | 1 | 0.024886 | 247 |
| TF | TF:M11653 | Factor: HSFY1; motif: NTTCGAANSNTTCGAAN | Factor: HSFY1; motif: NTTCGAANSNTTCGAAN | 1 | 0.049771 | 247 |
| TF | TF:M11653_1 | Factor: HSFY1; motif: NTTCGAANSNTTCGAAN; match class: 1 | Factor: HSFY1; motif: NTTCGAANSNTTCGAAN; match class: 1 | 1 | 0.049771 | 247 |
| TF | TF:M05894 | Factor: ZNF565; motif: NGTGAAAACGGA | Factor: ZNF565; motif: NGTGAAAACGGA | 1 | 0.049771 | 247 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034572 | Pigment incontinence | A process in which melanosomes (melanin granules) are deposited in the dermis. The dermal melanosomes are observed to be mainly in macrophages. This phenomenon of pigmentary incontinence usually follows an inflammatory process with the basic feature of basal cell damage, such as in lichen planus, lupus erythematosus, Riehl's melanosis, incontinentia pigmenti (Bloch-Sulzberger), and fixed drug eruption. Incontinence of pigment, or dropping off of epidermal melanin into the dermis, frequently produces a clinically recognizable and characteristic slate-gray pigmentation. | 1 | 0.049962 | 256 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-8985801 | Regulation of cortical dendrite branching | Regulation of cortical dendrite branching | 1 | 0.049932 | 258 |
| REAC | REAC:R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | SLIT2:ROBO1 increases RHOA activity | 1 | 0.049932 | 258 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011679 | Tetralogy of Fallot with pulmonary stenosis | The commonest form of tetralogy of Fallot characterized by pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy, without pulmonary atresia, absent pulmonary valve, atrioventricular canal defect or absent subarterial conus. | 1 | 0.049962 | 258 |
| HP | HP:0034976 | Absent pituitary stalk | A developmental defect characterized by failure to develop of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 258 |
| HP | HP:0034977 | Abnormal pituitary stalk morphology | A structural anomaly of the pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 258 |
| HP | HP:0034978 | Interrupted pituitary stalk | A developmental defect characterized by a discontinuity of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 258 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11925 | Factor: POU3F1; motif: NTAATGAKATGCGN | Factor: POU3F1; motif: NTAATGAKATGCGN | 1 | 0.012443 | 260 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031298 | replication fork protection complex | "A heterotrimeric replication-pausing complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. Required for maximal fork speed both in vivo and in vitro." [PMID:12944972, PMID:15367656, PMID:19819872] | 1 | 0.029966 | 263 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0580063 | Thymus; medullary cells[High] | Thymus; medullary cells[High] | 1 | 0.018400 | 265 |
| HPA | HPA:0580823 | Thymus; cortical cells[High] | Thymus; cortical cells[High] | 1 | 0.031544 | 265 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0035921 | desmosome disassembly | "The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:BHF, GOC:vk, ISBN:0198506732, PMID:9182671] | 1 | 0.049542 | 266 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:ebv-mir-bart12 | ebv-mir-bart12 | ebv-mir-bart12 | 1 | 0.00226 | 267 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0150051 | postsynaptic Golgi apparatus | "The network of the Golgi apparatus structures located within the postsynapse." [GOC:aruk, GOC:bc, PMID:23838184] | 1 | 0.019977 | 267 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140489 | molecular template activity | "The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence." [GOC:pg] | 1 | 0.024946 | 267 |
| GO:MF | GO:0140490 | microtubule nucleator activity | "The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly." [PMID:20631709, PMID:21993292] | 1 | 0.024946 | 267 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2276 | Glial cell differentiation | Glial cell differentiation | 1 | 0.04995 | 267 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004637 | phosphoribosylamine-glycine ligase activity | "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate." [EC:6.3.4.13, RHEA:17453] | 1 | 0.024946 | 272 |
| GO:MF | GO:0004641 | phosphoribosylformylglycinamidine cyclo-ligase activity | "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate." [EC:6.3.3.1, RHEA:23032] | 1 | 0.024946 | 272 |
| GO:MF | GO:0004644 | phosphoribosylglycinamide formyltransferase activity | "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2] | 1 | 0.024946 | 272 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00670 | One carbon pool by folate | One carbon pool by folate | 1 | 0.038394 | 272 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M04113 | Factor: GMEB2; motif: WACGTAACCACGTA | Factor: GMEB2; motif: WACGTAACCACGTA | 1 | 0.049771 | 274 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-3858516 | Glycogen storage disease type 0 (liver GYS2) | Glycogen storage disease type 0 (liver GYS2) | 1 | 0.024966 | 276 |
| REAC | REAC:R-HSA-3878781 | Glycogen storage disease type IV (GBE1) | Glycogen storage disease type IV (GBE1) | 1 | 0.037449 | 276 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0061547 | glycogen synthase activity, transferring glucose-1-phosphate | "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate." [GOC:dph, PMID:21356517] | 1 | 0.049891 | 276 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004831 | tyrosine-tRNA ligase activity | "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+." [EC:6.1.1.1, RHEA:10220] | 1 | 0.049891 | 277 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008894 | guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity | "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40] | 1 | 0.024946 | 280 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0048211 | Golgi vesicle docking | "The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] | 1 | 0.049542 | 282 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032105 | Macrosaccadic oscillations | A type of saccadic oscillations with brief periods of fixation between saccades (intersaccadic interval approximately 200 msec). Macrosaccadic oscillations (up to 40 degrees) straddle the intended fixation position and show a crescendo-decrescendo pattern. | 1 | 0.049962 | 283 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-518f-3p | hsa-mir-518f-3p | hsa-mir-518f-3p | 1 | 0.020336 | 289 |
| MIRNA | MIRNA:hsa-mir-518c-3p | hsa-mir-518c-3p | hsa-mir-518c-3p | 1 | 0.022595 | 289 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0021768 | nucleus accumbens development | "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] | 1 | 0.049542 | 292 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6785-3p | hsa-mir-6785-3p | hsa-mir-6785-3p | 1 | 0.020336 | 294 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032390 | Periventricular ribbonlike heterotopia | Heterotopia that forms a continuous wavy line along the ventricular wall. | 1 | 0.049962 | 294 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00061 | Fatty acid biosynthesis | Fatty acid biosynthesis | 1 | 0.034554 | 296 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06362 | Factor: ZNF730; motif: KGGGACWAAAGM | Factor: ZNF730; motif: KGGGACWAAAGM | 1 | 0.037328 | 299 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0260152 | Hypothalamus; synapses[≥Medium] | Hypothalamus; synapses[≥Medium] | 1 | 0.026286 | 302 |
| HPA | HPA:0260151 | Hypothalamus; synapses[≥Low] | Hypothalamus; synapses[≥Low] | 1 | 0.031544 | 302 |
| HPA | HPA:0260143 | Hypothalamus; neuronal projections[High] | Hypothalamus; neuronal projections[High] | 1 | 0.042058 | 302 |
| HPA | HPA:0020063 | Adrenal gland; medullary cells[High] | Adrenal gland; medullary cells[High] | 1 | 0.049944 | 302 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0032812 | positive regulation of epinephrine secretion | "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] | 1 | 0.049542 | 302 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004463 | leukotriene-A4 hydrolase activity | "Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22324] | 1 | 0.024946 | 309 |
| GO:MF | GO:0034701 | tripeptidase activity | "Catalysis of the hydrolysis of a tripeptide." [GOC:mah] | 1 | 0.024946 | 309 |
| GO:MF | GO:0045148 | tripeptide aminopeptidase activity | "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide." [EC:3.4.11.4] | 1 | 0.024946 | 309 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9020265 | Biosynthesis of aspirin-triggered D-series resolvins | Biosynthesis of aspirin-triggered D-series resolvins | 1 | 0.024966 | 309 |
| REAC | REAC:R-HSA-9018676 | Biosynthesis of D-series resolvins | Biosynthesis of D-series resolvins | 1 | 0.037449 | 309 |
| REAC | REAC:R-HSA-9023661 | Biosynthesis of E-series 18(R)-resolvins | Biosynthesis of E-series 18(R)-resolvins | 1 | 0.037449 | 309 |
| REAC | REAC:R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | Biosynthesis of E-series 18(S)-resolvins | 1 | 0.049932 | 309 |
| REAC | REAC:R-HSA-9018681 | Biosynthesis of protectins | Biosynthesis of protectins | 1 | 0.049932 | 309 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6310 | DEAF1- complex | DEAF1- complex | 1 | 0.024966 | 311 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05312_1 | Factor: FKLF; motif: AGGGCGGGTG; match class: 1 | Factor: FKLF; motif: AGGGCGGGTG; match class: 1 | 1 | 0.037328 | 311 |
| TF | TF:M05552_1 | Factor: SP5; motif: NGGGCGGGTS; match class: 1 | Factor: SP5; motif: NGGGCGGGTS; match class: 1 | 1 | 0.037328 | 311 |
| TF | TF:M05553_1 | Factor: SP8; motif: WGGGCGGGTS; match class: 1 | Factor: SP8; motif: WGGGCGGGTS; match class: 1 | 1 | 0.037328 | 311 |
| TF | TF:M05493_1 | Factor: SP9; motif: NGGGCGGGTS; match class: 1 | Factor: SP9; motif: NGGGCGGGTS; match class: 1 | 1 | 0.037328 | 311 |
| TF | TF:M05360_1 | Factor: TIEG-1; motif: WGGGCGGGTG; match class: 1 | Factor: TIEG-1; motif: WGGGCGGGTG; match class: 1 | 1 | 0.037328 | 311 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990589 | ATF4-CREB1 transcription factor complex | "Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway." [GOC:bhm, PMID:12871976] | 1 | 0.039955 | 312 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990533 | Dom34-Hbs1 complex | "A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay." [GOC:mcc, PMID:20890290, PMID:21102444, PMID:21448132, PMID:22503425] | 1 | 0.019977 | 313 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M04266 | Factor: FOXO6; motif: TTTCCCCACACGAC | Factor: FOXO6; motif: TTTCCCCACACGAC | 1 | 0.049771 | 314 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1537-3p | hsa-mir-1537-3p | hsa-mir-1537-3p | 1 | 0.033893 | 315 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6524 | DZIP1-GLI3 complex | DZIP1-GLI3 complex | 1 | 0.024966 | 316 |
| CORUM | CORUM:6531 | CEP164-DZIP1 complex | CEP164-DZIP1 complex | 1 | 0.049932 | 316 |
| CORUM | CORUM:6533 | DZIP1-IFT88 complex | DZIP1-IFT88 complex | 1 | 0.049932 | 316 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0062063 | BBSome binding | "Binding to a BBSome complex." [PMID:20603001] | 1 | 0.049891 | 316 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000110 | nucleotide-excision repair factor 1 complex | "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862] | 1 | 0.029966 | 318 |
| GO:CC | GO:0070522 | ERCC4-ERCC1 complex | "A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae." [PMID:14734547] | 1 | 0.039955 | 318 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7363 | EYA1-SIX1 complex | EYA1-SIX1 complex | 1 | 0.049932 | 319 |
| CORUM | CORUM:7364 | EYA1-SIX2 complex | EYA1-SIX2 complex | 1 | 0.049932 | 319 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M07108_1 | Factor: MafF; motif: NCTNASTCAGCANWWTNN; match class: 1 | Factor: MafF; motif: NCTNASTCAGCANWWTNN; match class: 1 | 1 | 0.037328 | 321 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06037 | Factor: ZNF197; motif: NRGGCAATAAGM | Factor: ZNF197; motif: NRGGCAATAAGM | 1 | 0.024886 | 323 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-132-5p | hsa-mir-132-5p | hsa-mir-132-5p | 1 | 0.038412 | 323 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6961 | CTNNB1-GID8 complex | CTNNB1-GID8 complex | 1 | 0.049932 | 323 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0043159 | acrosomal matrix | "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729] | 1 | 0.039955 | 325 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002077 | acrosome matrix dispersal | "The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane." [GOC:dph, PMID:3886029] | 1 | 0.049542 | 325 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0036457 | keratohyalin granule | "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope." [GOC:krc, PMID:15854042] | 1 | 0.039955 | 327 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004309 | exopolyphosphatase activity | "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11] | 1 | 0.024946 | 328 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:758 | Prune/Nm23-H1 complex | Prune/Nm23-H1 complex | 1 | 0.024966 | 328 |
| CORUM | CORUM:756 | Prune-Gelsolin complex | Prune-Gelsolin complex | 1 | 0.049932 | 328 |
| CORUM | CORUM:757 | Prune-GSK3beta complex | Prune-GSK3beta complex | 1 | 0.049932 | 328 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016603 | glutaminyl-peptide cyclotransferase activity | "Catalysis of the reaction: N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4+." [RHEA:23652] | 1 | 0.049891 | 329 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06467 | Factor: ZNF695; motif: NTGTYCATCATT | Factor: ZNF695; motif: NTGTYCATCATT | 1 | 0.037328 | 330 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 209 | 8.191896e-32 | 0 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 140 | 7.818887e-30 | 0 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 92 | 4.303493e-28 | 0 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 79 | 9.056693e-20 | 0 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 79 | 2.549343e-19 | 0 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 59 | 2.636160e-18 | 0 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 42 | 3.891242e-17 | 0 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 45 | 8.888536e-17 | 0 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 71 | 1.621943e-15 | 0 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 44 | 1.650857e-15 | 0 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 53 | 5.772192e-14 | 0 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 42 | 1.307138e-11 | 0 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 42 | 1.681674e-11 | 0 |
| GO:CC | GO:0030877 | beta-catenin destruction complex | "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] | 8 | 1.826523e-11 | 0 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 27 | 2.452985e-11 | 0 |
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 29 | 7.621113e-11 | 0 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 26 | 1.031510e-10 | 0 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 35 | 2.503903e-10 | 0 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 51 | 2.688979e-10 | 0 |
| GO:CC | GO:0030424 | axon | "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] | 31 | 4.652786e-10 | 0 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 26 | 2.713230e-09 | 0 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 116 | 4.711002e-09 | 0 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 116 | 4.761282e-09 | 0 |
| GO:CC | GO:0031252 | cell leading edge | "The area of a motile cell closest to the direction of movement." [GOC:pg] | 24 | 6.836696e-09 | 0 |
| GO:CC | GO:0005912 | adherens junction | "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] | 16 | 4.018424e-08 | 0 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 30 | 1.480819e-07 | 0 |
| GO:CC | GO:0098978 | glutamatergic synapse | "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] | 26 | 2.208114e-07 | 0 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 24 | 3.591467e-07 | 0 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 19 | 4.630051e-07 | 0 |
| GO:CC | GO:0005814 | centriole | "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] | 14 | 4.647006e-07 | 0 |
| GO:CC | GO:1990909 | Wnt signalosome | "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320] | 6 | 6.344801e-07 | 0 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 213 | 8.273474e-07 | 0 |
| GO:CC | GO:0036064 | ciliary basal body | "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193] | 14 | 1.182699e-06 | 0 |
| GO:CC | GO:0043005 | neuron projection | "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] | 38 | 4.272944e-06 | 0 |
| GO:CC | GO:0048471 | perinuclear region of cytoplasm | "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] | 27 | 4.472195e-06 | 0 |
| GO:CC | GO:0005819 | spindle | "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] | 20 | 9.565531e-06 | 0 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 198 | 9.836066e-06 | 0 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 204 | 9.920814e-06 | 0 |
| GO:CC | GO:0043296 | apical junction complex | "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556] | 12 | 2.487752e-05 | 0 |
| GO:CC | GO:0005875 | microtubule associated complex | "Any multimeric complex connected to a microtubule." [GOC:jl] | 12 | 3.296281e-05 | 0 |
| GO:CC | GO:0034451 | centriolar satellite | "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812] | 11 | 3.307429e-05 | 0 |
| GO:CC | GO:0030027 | lamellipodium | "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194] | 13 | 6.910170e-05 | 0 |
| GO:CC | GO:0030496 | midbody | "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] | 13 | 8.648878e-05 | 0 |
| GO:CC | GO:0016342 | catenin complex | "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] | 6 | 2.336351e-04 | 0 |
| GO:CC | GO:0036477 | somatodendritic compartment | "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL] | 26 | 2.813167e-04 | 0 |
| GO:CC | GO:0005915 | zonula adherens | "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208] | 4 | 4.791408e-04 | 0 |
| GO:CC | GO:0000776 | kinetochore | "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] | 11 | 6.331823e-04 | 0 |
| GO:CC | GO:0005929 | cilium | "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] | 24 | 6.959959e-04 | 0 |
| GO:CC | GO:0030425 | dendrite | "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] | 21 | 8.561036e-04 | 0 |
| GO:CC | GO:0019897 | extrinsic component of plasma membrane | "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] | 9 | 8.958181e-04 | 0 |
| GO:CC | GO:0097447 | dendritic tree | "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168] | 21 | 8.993855e-04 | 0 |
| GO:CC | GO:0000922 | spindle pole | "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] | 11 | 9.325680e-04 | 0 |
| GO:CC | GO:0099572 | postsynaptic specialization | "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028] | 16 | 1.191463e-03 | 0 |
| GO:CC | GO:0000779 | condensed chromosome, centromeric region | "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] | 11 | 1.216382e-03 | 0 |
| GO:CC | GO:0002102 | podosome | "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] | 6 | 1.310815e-03 | 0 |
| GO:CC | GO:0099091 | postsynaptic specialization, intracellular component | "A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos] | 5 | 1.434035e-03 | 0 |
| GO:CC | GO:0016327 | apicolateral plasma membrane | "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] | 5 | 1.434035e-03 | 0 |
| GO:CC | GO:0098984 | neuron to neuron synapse | "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos] | 16 | 1.913265e-03 | 0 |
| GO:CC | GO:0098590 | plasma membrane region | "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] | 32 | 1.995555e-03 | 0 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 95 | 3.268213e-03 | 0 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 89 | 4.583601e-03 | 0 |
| GO:CC | GO:0000775 | chromosome, centromeric region | "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] | 12 | 6.508494e-03 | 0 |
| GO:CC | GO:0014069 | postsynaptic density | "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density] | 14 | 7.148642e-03 | 0 |
| GO:CC | GO:0072686 | mitotic spindle | "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] | 10 | 7.862772e-03 | 0 |
| GO:CC | GO:0019898 | extrinsic component of membrane | "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] | 10 | 9.889253e-03 | 0 |
| GO:CC | GO:0097517 | contractile actin filament bundle | "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194] | 7 | 1.055776e-02 | 0 |
| GO:CC | GO:0001725 | stress fiber | "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] | 7 | 1.055776e-02 | 0 |
| GO:CC | GO:1990752 | microtubule end | "Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end." [GOC:pr] | 5 | 1.151739e-02 | 0 |
| GO:CC | GO:0032279 | asymmetric synapse | "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] | 14 | 1.158036e-02 | 0 |
| GO:CC | GO:0016328 | lateral plasma membrane | "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] | 7 | 1.226162e-02 | 0 |
| GO:CC | GO:0030056 | hemidesmosome | "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195] | 3 | 1.340905e-02 | 0 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 24 | 1.414327e-02 | 0 |
| GO:CC | GO:0099092 | postsynaptic density, intracellular component | "A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos] | 4 | 1.687364e-02 | 0 |
| GO:CC | GO:0042641 | actomyosin | "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] | 7 | 1.753012e-02 | 0 |
| GO:CC | GO:1904115 | axon cytoplasm | "Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152] | 6 | 1.799389e-02 | 0 |
| GO:CC | GO:0032432 | actin filament bundle | "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] | 7 | 2.009971e-02 | 0 |
| GO:CC | GO:0030018 | Z disc | "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] | 8 | 2.389979e-02 | 0 |
| GO:CC | GO:0000242 | pericentriolar material | "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] | 4 | 2.507274e-02 | 0 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 11 | 2.700331e-02 | 0 |
| GO:CC | GO:0000932 | P-body | "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603] | 7 | 2.971805e-02 | 0 |
| GO:CC | GO:0005916 | fascia adherens | "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:aruk, GOC:bc, GOC:mtg_muscle, PMID:11732910] | 3 | 3.170065e-02 | 0 |
| GO:CC | GO:0016600 | flotillin complex | "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709] | 3 | 3.170065e-02 | 0 |
| GO:CC | GO:0099568 | cytoplasmic region | "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos] | 12 | 3.514803e-02 | 0 |
| GO:CC | GO:0098685 | Schaffer collateral - CA1 synapse | "A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell." [PMID:16399689] | 7 | 3.577414e-02 | 0 |
| GO:CC | GO:0034750 | Scrib-APC-beta-catenin complex | "A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation." [PMID:16611247] | 2 | 3.921395e-02 | 0 |
| GO:CC | GO:0097546 | ciliary base | "Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444] | 5 | 4.279690e-02 | 0 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 129 | 4.470350e-02 | 0 |
| GO:CC | GO:0120103 | centriolar subdistal appendage | "A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68." [GOC:cilia, PMID:23213374, PMID:27818179, PMID:28422092] | 3 | 4.494712e-02 | 0 |
| GO:CC | GO:0044291 | cell-cell contact zone | "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018] | 6 | 4.741907e-02 | 0 |
| GO:CC | GO:0035371 | microtubule plus-end | "The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273] | 4 | 4.963485e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 76 | 6.769872e-28 | 0 |
| GO:BP | GO:0007017 | microtubule-based process | "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] | 52 | 1.822700e-18 | 0 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 43 | 4.074191e-18 | 0 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 98 | 3.044622e-17 | 0 |
| GO:BP | GO:0016055 | Wnt signaling pathway | "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397] | 35 | 1.297401e-16 | 0 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 57 | 1.303725e-16 | 0 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 77 | 6.529298e-16 | 0 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 58 | 1.058507e-15 | 0 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 58 | 1.093813e-15 | 0 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488] | 28 | 1.219125e-14 | 0 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 91 | 2.706521e-14 | 0 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 90 | 1.087626e-13 | 0 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 83 | 1.157821e-13 | 0 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 92 | 2.284134e-13 | 0 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 190 | 2.472861e-13 | 0 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 59 | 3.530473e-13 | 0 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 193 | 4.635061e-13 | 0 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 186 | 5.262139e-13 | 0 |
| GO:BP | GO:0030030 | cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917] | 57 | 1.648304e-12 | 0 |
| GO:BP | GO:0032886 | regulation of microtubule-based process | "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] | 24 | 3.080323e-12 | 0 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 76 | 3.924393e-12 | 0 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 76 | 4.969278e-12 | 0 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] | 26 | 5.455374e-12 | 0 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 127 | 8.343305e-12 | 0 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] | 55 | 8.893521e-12 | 0 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 126 | 1.747100e-11 | 0 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] | 22 | 1.245426e-10 | 0 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 80 | 1.513864e-10 | 0 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] | 21 | 2.190671e-10 | 0 |
| GO:BP | GO:0007165 | signal transduction | "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] | 117 | 2.875021e-10 | 0 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] | 71 | 5.321874e-10 | 0 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 116 | 7.360125e-10 | 0 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 29 | 7.427111e-10 | 0 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] | 18 | 9.687925e-10 | 0 |
| GO:BP | GO:0031023 | microtubule organizing center organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] | 17 | 1.646162e-09 | 0 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 131 | 3.150153e-09 | 0 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 57 | 3.513064e-09 | 0 |
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb] | 16 | 4.078523e-09 | 0 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 88 | 4.078568e-09 | 0 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 73 | 4.461294e-09 | 0 |
| GO:BP | GO:0070507 | regulation of microtubule cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 17 | 5.149044e-09 | 0 |
| GO:BP | GO:0007399 | nervous system development | "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] | 67 | 7.275986e-09 | 0 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 39 | 7.360746e-09 | 0 |
| GO:BP | GO:0034453 | microtubule anchoring | "Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah] | 9 | 9.067638e-09 | 0 |
| GO:BP | GO:0071539 | protein localization to centrosome | "A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd] | 10 | 9.494233e-09 | 0 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 88 | 9.525882e-09 | 0 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 120 | 1.081678e-08 | 0 |
| GO:BP | GO:1905508 | protein localization to microtubule organizing center | "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497] | 10 | 1.276476e-08 | 0 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 54 | 1.771635e-08 | 0 |
| GO:BP | GO:0000902 | cell morphogenesis | "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] | 38 | 1.900220e-08 | 0 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 36 | 2.368435e-08 | 0 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 138 | 2.407056e-08 | 0 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 96 | 2.836044e-08 | 0 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 44 | 3.068153e-08 | 0 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 69 | 3.092938e-08 | 0 |
| GO:BP | GO:0031175 | neuron projection development | "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] | 38 | 4.184963e-08 | 0 |
| GO:BP | GO:0034330 | cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] | 34 | 4.628582e-08 | 0 |
| GO:BP | GO:0072698 | protein localization to microtubule cytoskeleton | "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah] | 11 | 5.278632e-08 | 0 |
| GO:BP | GO:0030182 | neuron differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] | 46 | 5.301562e-08 | 0 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 106 | 5.364460e-08 | 0 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 30 | 6.120407e-08 | 0 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 69 | 7.728079e-08 | 0 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 40 | 8.066041e-08 | 0 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc] | 30 | 1.021210e-07 | 0 |
| GO:BP | GO:0048699 | generation of neurons | "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] | 47 | 1.032701e-07 | 0 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 34 | 1.089998e-07 | 0 |
| GO:BP | GO:0044380 | protein localization to cytoskeleton | "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl] | 11 | 1.134801e-07 | 0 |
| GO:BP | GO:0048858 | cell projection morphogenesis | "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021] | 30 | 1.222041e-07 | 0 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] | 27 | 1.284527e-07 | 0 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 55 | 1.685125e-07 | 0 |
| GO:BP | GO:0048666 | neuron development | "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] | 40 | 1.710128e-07 | 0 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 138 | 1.942234e-07 | 0 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 37 | 2.719517e-07 | 0 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] | 29 | 2.792939e-07 | 0 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 105 | 3.078334e-07 | 0 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 54 | 3.671147e-07 | 0 |
| GO:BP | GO:0022008 | neurogenesis | "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] | 50 | 3.769462e-07 | 0 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 43 | 4.724236e-07 | 0 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 36 | 4.891271e-07 | 0 |
| GO:BP | GO:0006468 | protein phosphorylation | "The process of introducing a phosphate group on to a protein." [GOC:hb] | 40 | 5.889916e-07 | 0 |
| GO:BP | GO:0007098 | centrosome cycle | "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] | 14 | 7.532148e-07 | 0 |
| GO:BP | GO:0044093 | positive regulation of molecular function | "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 33 | 9.179975e-07 | 0 |
| GO:BP | GO:0034329 | cell junction assembly | "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah] | 24 | 2.436683e-06 | 0 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 105 | 2.770931e-06 | 0 |
| GO:BP | GO:0030010 | establishment of cell polarity | "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] | 14 | 4.060238e-06 | 0 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 141 | 4.223281e-06 | 0 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 43 | 5.462552e-06 | 0 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 33 | 6.539424e-06 | 0 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 105 | 6.653915e-06 | 0 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 33 | 6.710483e-06 | 0 |
| GO:BP | GO:0072393 | microtubule anchoring at microtubule organizing center | "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938] | 6 | 8.401950e-06 | 0 |
| GO:BP | GO:0007155 | cell adhesion | "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] | 43 | 1.068319e-05 | 0 |
| GO:BP | GO:0032501 | multicellular organismal process | "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] | 121 | 1.139447e-05 | 0 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 65 | 1.171701e-05 | 0 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 24 | 1.217578e-05 | 0 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] | 11 | 1.430032e-05 | 0 |
| GO:BP | GO:0070925 | organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 34 | 1.662124e-05 | 0 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 34 | 1.784689e-05 | 0 |
| GO:BP | GO:0030154 | cell differentiation | "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] | 85 | 1.810986e-05 | 0 |
| GO:BP | GO:0048869 | cellular developmental process | "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] | 85 | 1.831044e-05 | 0 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 63 | 1.928449e-05 | 0 |
| GO:BP | GO:0150115 | cell-substrate junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 11 | 3.028292e-05 | 0 |
| GO:BP | GO:0099111 | microtubule-based transport | "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] | 15 | 3.550424e-05 | 0 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 107 | 3.766623e-05 | 0 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 48 | 4.283323e-05 | 0 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 31 | 4.409706e-05 | 0 |
| GO:BP | GO:0048870 | cell motility | "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] | 46 | 4.715902e-05 | 0 |
| GO:BP | GO:0042325 | regulation of phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] | 29 | 5.009785e-05 | 0 |
| GO:BP | GO:0031109 | microtubule polymerization or depolymerization | "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] | 12 | 6.846495e-05 | 0 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 65 | 7.107961e-05 | 0 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb] | 24 | 7.150944e-05 | 0 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 19 | 7.704169e-05 | 0 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 55 | 8.007831e-05 | 0 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 55 | 8.355354e-05 | 0 |
| GO:BP | GO:0032007 | negative regulation of TOR signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah] | 9 | 9.670255e-05 | 0 |
| GO:BP | GO:0031344 | regulation of cell projection organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] | 25 | 1.020857e-04 | 0 |
| GO:BP | GO:0016477 | cell migration | "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] | 41 | 1.053852e-04 | 0 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 39 | 1.096299e-04 | 0 |
| GO:BP | GO:0010970 | transport along microtubule | "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] | 13 | 1.459566e-04 | 0 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 32 | 1.675646e-04 | 0 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 24 | 1.729580e-04 | 0 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 35 | 1.750808e-04 | 0 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] | 27 | 1.870858e-04 | 0 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 26 | 1.891747e-04 | 0 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 63 | 2.068057e-04 | 0 |
| GO:BP | GO:0031110 | regulation of microtubule polymerization or depolymerization | "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] | 10 | 2.155913e-04 | 0 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 24 | 2.315939e-04 | 0 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 24 | 2.673718e-04 | 0 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 48 | 2.778036e-04 | 0 |
| GO:BP | GO:0060429 | epithelium development | "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] | 35 | 3.102321e-04 | 0 |
| GO:BP | GO:0007507 | heart development | "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] | 23 | 3.592939e-04 | 0 |
| GO:BP | GO:0071896 | protein localization to adherens junction | "Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237] | 4 | 3.994138e-04 | 0 |
| GO:BP | GO:0048729 | tissue morphogenesis | "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] | 23 | 4.664139e-04 | 0 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 19 | 4.682684e-04 | 0 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 27 | 5.863709e-04 | 0 |
| GO:BP | GO:1903050 | regulation of proteolysis involved in protein catabolic process | "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 14 | 6.007568e-04 | 0 |
| GO:BP | GO:0007160 | cell-matrix adhesion | "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] | 14 | 6.324657e-04 | 0 |
| GO:BP | GO:0043087 | regulation of GTPase activity | "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] | 13 | 6.362072e-04 | 0 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 32 | 6.685638e-04 | 0 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] | 27 | 6.760814e-04 | 0 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 12 | 6.800960e-04 | 0 |
| GO:BP | GO:0048041 | focal adhesion assembly | "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah] | 9 | 6.897905e-04 | 0 |
| GO:BP | GO:0031346 | positive regulation of cell projection organization | "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] | 17 | 7.347277e-04 | 0 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 26 | 8.096599e-04 | 0 |
| GO:BP | GO:0051656 | establishment of organelle localization | "The directed movement of an organelle to a specific location." [GOC:ai] | 20 | 8.128851e-04 | 0 |
| GO:BP | GO:0030705 | cytoskeleton-dependent intracellular transport | "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] | 13 | 9.399357e-04 | 0 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 92 | 9.594476e-04 | 0 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 33 | 9.783891e-04 | 0 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 18 | 1.246196e-03 | 0 |
| GO:BP | GO:0045216 | cell-cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 13 | 1.297231e-03 | 0 |
| GO:BP | GO:0007409 | axonogenesis | "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] | 19 | 1.437402e-03 | 0 |
| GO:BP | GO:0022607 | cellular component assembly | "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] | 83 | 1.485616e-03 | 0 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] | 13 | 1.517799e-03 | 0 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 55 | 1.662140e-03 | 0 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] | 10 | 1.695131e-03 | 0 |
| GO:BP | GO:0051640 | organelle localization | "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] | 22 | 2.142313e-03 | 0 |
| GO:BP | GO:0007043 | cell-cell junction assembly | "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] | 11 | 2.146563e-03 | 0 |
| GO:BP | GO:1901888 | regulation of cell junction assembly | "Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] | 14 | 2.209673e-03 | 0 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 52 | 2.299364e-03 | 0 |
| GO:BP | GO:0007018 | microtubule-based movement | "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] | 19 | 2.312796e-03 | 0 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 40 | 2.435779e-03 | 0 |
| GO:BP | GO:0061564 | axon development | "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr] | 20 | 2.517830e-03 | 0 |
| GO:BP | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] | 7 | 2.790945e-03 | 0 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 82 | 3.092098e-03 | 0 |
| GO:BP | GO:0031589 | cell-substrate adhesion | "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] | 16 | 3.494712e-03 | 0 |
| GO:BP | GO:0010975 | regulation of neuron projection development | "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] | 18 | 3.612424e-03 | 0 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc] | 22 | 3.795917e-03 | 0 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 20 | 3.864338e-03 | 0 |
| GO:BP | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 9 | 4.180893e-03 | 0 |
| GO:BP | GO:0043547 | positive regulation of GTPase activity | "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] | 10 | 4.289852e-03 | 0 |
| GO:BP | GO:0030162 | regulation of proteolysis | "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] | 17 | 4.312393e-03 | 0 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 29 | 4.428076e-03 | 0 |
| GO:BP | GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 10 | 4.587285e-03 | 0 |
| GO:BP | GO:0120031 | plasma membrane bounded cell projection assembly | "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 21 | 4.736206e-03 | 0 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] | 19 | 4.896320e-03 | 0 |
| GO:BP | GO:0035088 | establishment or maintenance of apical/basal cell polarity | "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483] | 7 | 5.269861e-03 | 0 |
| GO:BP | GO:0061245 | establishment or maintenance of bipolar cell polarity | "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns." [GOC:dph, GOC:vw] | 7 | 5.269861e-03 | 0 |
| GO:BP | GO:0034332 | adherens junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah] | 7 | 5.269861e-03 | 0 |
| GO:BP | GO:0001837 | epithelial to mesenchymal transition | "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] | 11 | 5.287702e-03 | 0 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 33 | 5.613568e-03 | 0 |
| GO:BP | GO:1900181 | negative regulation of protein localization to nucleus | "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 6 | 6.225735e-03 | 0 |
| GO:BP | GO:0030031 | cell projection assembly | "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:18391171] | 21 | 6.618531e-03 | 0 |
| GO:BP | GO:0070884 | regulation of calcineurin-NFAT signaling cascade | "Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:ai] | 6 | 7.292002e-03 | 0 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 84 | 7.298564e-03 | 0 |
| GO:BP | GO:0106056 | regulation of calcineurin-mediated signaling | "Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204] | 6 | 8.502253e-03 | 0 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 22 | 8.930767e-03 | 0 |
| GO:BP | GO:0035148 | tube formation | "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf] | 10 | 9.825178e-03 | 0 |
| GO:BP | GO:0090109 | regulation of cell-substrate junction assembly | "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb] | 7 | 1.044174e-02 | 0 |
| GO:BP | GO:0051893 | regulation of focal adhesion assembly | "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai] | 7 | 1.044174e-02 | 0 |
| GO:BP | GO:0034454 | microtubule anchoring at centrosome | "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah] | 4 | 1.252740e-02 | 0 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] | 14 | 1.338503e-02 | 0 |
| GO:BP | GO:0060322 | head development | "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph] | 24 | 1.419110e-02 | 0 |
| GO:BP | GO:0007420 | brain development | "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] | 23 | 1.512071e-02 | 0 |
| GO:BP | GO:0030901 | midbrain development | "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [PMID:4975589, PMID:4992177] | 8 | 1.523651e-02 | 0 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 38 | 1.698896e-02 | 0 |
| GO:BP | GO:0150116 | regulation of cell-substrate junction organization | "Any process that modulates the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] | 7 | 1.748234e-02 | 0 |
| GO:BP | GO:0045184 | establishment of protein localization | "The directed movement of a protein to a specific location." [GOC:bf] | 42 | 1.750611e-02 | 0 |
| GO:BP | GO:0010631 | epithelial cell migration | "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb] | 8 | 1.785382e-02 | 0 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 65 | 1.814240e-02 | 0 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 62 | 1.895741e-02 | 0 |
| GO:BP | GO:0051017 | actin filament bundle assembly | "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] | 10 | 1.961747e-02 | 0 |
| GO:BP | GO:0033173 | calcineurin-NFAT signaling cascade | "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+)." [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679] | 6 | 1.966203e-02 | 0 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 59 | 2.009316e-02 | 0 |
| GO:BP | GO:0061136 | regulation of proteasomal protein catabolic process | "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] | 11 | 2.054902e-02 | 0 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 35 | 2.073762e-02 | 0 |
| GO:BP | GO:0048589 | developmental growth | "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] | 21 | 2.196107e-02 | 0 |
| GO:BP | GO:0090132 | epithelium migration | "The process in which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] | 8 | 2.248563e-02 | 0 |
| GO:BP | GO:0046785 | microtubule polymerization | "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] | 8 | 2.248563e-02 | 0 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 19 | 2.272370e-02 | 0 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 19 | 2.272370e-02 | 0 |
| GO:BP | GO:0005979 | regulation of glycogen biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] | 5 | 2.296969e-02 | 0 |
| GO:BP | GO:0010962 | regulation of glucan biosynthetic process | "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb] | 5 | 2.296969e-02 | 0 |
| GO:BP | GO:0061572 | actin filament bundle organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] | 10 | 2.309467e-02 | 0 |
| GO:BP | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] | 9 | 2.429220e-02 | 0 |
| GO:BP | GO:0050808 | synapse organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] | 19 | 2.448734e-02 | 0 |
| GO:BP | GO:0071681 | cellular response to indole-3-methanol | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf] | 3 | 2.512776e-02 | 0 |
| GO:BP | GO:0097720 | calcineurin-mediated signaling | "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544] | 6 | 2.530207e-02 | 0 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] | 9 | 2.584366e-02 | 0 |
| GO:BP | GO:0051258 | protein polymerization | "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] | 13 | 2.764077e-02 | 0 |
| GO:BP | GO:0003281 | ventricular septum development | "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] | 7 | 2.807660e-02 | 0 |
| GO:BP | GO:0031929 | TOR signaling | "The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295] | 10 | 2.854917e-02 | 0 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] | 30 | 2.988612e-02 | 0 |
| GO:BP | GO:0072359 | circulatory system development | "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] | 29 | 3.360658e-02 | 0 |
| GO:BP | GO:0106057 | negative regulation of calcineurin-mediated signaling | "Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204] | 4 | 3.367955e-02 | 0 |
| GO:BP | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | "Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:mah] | 4 | 3.367955e-02 | 0 |
| GO:BP | GO:0150011 | regulation of neuron projection arborization | "Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches." [GOC:aruk, GOC:bc, PMID:17114044] | 4 | 3.367955e-02 | 0 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 25 | 3.376710e-02 | 0 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 60 | 3.445267e-02 | 0 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 14 | 3.460490e-02 | 0 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 14 | 3.460490e-02 | 0 |
| GO:BP | GO:0090130 | tissue migration | "The process in which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] | 8 | 3.482958e-02 | 0 |
| GO:BP | GO:0072659 | protein localization to plasma membrane | "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] | 13 | 3.575509e-02 | 0 |
| GO:BP | GO:0006886 | intracellular protein transport | "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] | 21 | 3.653698e-02 | 0 |
| GO:BP | GO:0000422 | autophagy of mitochondrion | "The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344] | 8 | 3.735730e-02 | 0 |
| GO:BP | GO:0043297 | apical junction assembly | "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556] | 7 | 3.995973e-02 | 0 |
| GO:BP | GO:0010717 | regulation of epithelial to mesenchymal transition | "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] | 8 | 4.003736e-02 | 0 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 20 | 4.073830e-02 | 0 |
| GO:BP | GO:0031032 | actomyosin structure organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] | 11 | 4.085505e-02 | 0 |
| GO:BP | GO:0046328 | regulation of JNK cascade | "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] | 9 | 4.404211e-02 | 0 |
| GO:BP | GO:1903828 | negative regulation of protein localization | "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 11 | 4.653778e-02 | 0 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 20 | 4.865392e-02 | 0 |
| GO:BP | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA | "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544] | 3 | 4.985610e-02 | 0 |
| GO:BP | GO:0071680 | response to indole-3-methanol | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf] | 3 | 4.985610e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 25 | 5.854465e-19 | 0 |
| KEGG | KEGG:04310 | Wnt signaling pathway | Wnt signaling pathway | 19 | 5.350567e-11 | 0 |
| KEGG | KEGG:05217 | Basal cell carcinoma | Basal cell carcinoma | 12 | 1.663784e-09 | 0 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 15 | 5.184380e-08 | 0 |
| KEGG | KEGG:05224 | Breast cancer | Breast cancer | 14 | 4.600250e-07 | 0 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 20 | 5.659622e-07 | 0 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 24 | 3.936414e-06 | 0 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 13 | 1.740975e-05 | 0 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 21 | 5.030832e-05 | 0 |
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 8 | 6.109626e-05 | 0 |
| KEGG | KEGG:04520 | Adherens junction | Adherens junction | 9 | 2.552893e-04 | 0 |
| KEGG | KEGG:04150 | mTOR signaling pathway | mTOR signaling pathway | 11 | 4.220383e-04 | 0 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 10 | 6.112624e-04 | 0 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 17 | 6.547132e-04 | 0 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | Signaling pathways regulating pluripotency of stem cells | 10 | 1.329692e-03 | 0 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 10 | 2.397535e-03 | 0 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | Bacterial invasion of epithelial cells | 7 | 5.118761e-03 | 0 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 12 | 6.757615e-03 | 0 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | Leukocyte transendothelial migration | 8 | 9.624077e-03 | 0 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 11 | 1.238233e-02 | 0 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 8 | 1.378036e-02 | 0 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 14 | 1.691062e-02 | 0 |
| KEGG | KEGG:04140 | Autophagy - animal | Autophagy - animal | 9 | 2.446803e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 52 | 6.063282e-18 | 0 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 219 | 1.682781e-13 | 0 |
| GO:MF | GO:0008013 | beta-catenin binding | "Binding to a catenin beta subunit." [GOC:bf] | 17 | 2.424305e-12 | 0 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 63 | 1.718770e-10 | 0 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 35 | 2.984330e-09 | 0 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 32 | 1.789779e-08 | 0 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 21 | 1.268694e-07 | 0 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 27 | 1.467089e-07 | 0 |
| GO:MF | GO:0008017 | microtubule binding | "Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc] | 18 | 1.767381e-06 | 0 |
| GO:MF | GO:0015631 | tubulin binding | "Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] | 20 | 1.134570e-05 | 0 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 26 | 1.512042e-05 | 0 |
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 21 | 1.709744e-05 | 0 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 36 | 5.339790e-05 | 0 |
| GO:MF | GO:0048156 | tau protein binding | "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] | 7 | 2.212744e-04 | 0 |
| GO:MF | GO:0051018 | protein kinase A binding | "Binding to a protein kinase A." [GOC:ai] | 7 | 1.093215e-03 | 0 |
| GO:MF | GO:0004721 | phosphoprotein phosphatase activity | "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684] | 14 | 1.648577e-03 | 0 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 25 | 1.649857e-03 | 0 |
| GO:MF | GO:0017166 | vinculin binding | "Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544] | 4 | 3.223307e-03 | 0 |
| GO:MF | GO:0045295 | gamma-catenin binding | "Binding to catenin complex gamma subunit." [GOC:bf] | 4 | 3.223307e-03 | 0 |
| GO:MF | GO:0016791 | phosphatase activity | "Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate." [GOC:curators, GOC:pg] | 16 | 4.506628e-03 | 0 |
| GO:MF | GO:0051011 | microtubule minus-end binding | "Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] | 4 | 4.614231e-03 | 0 |
| GO:MF | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity | "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [GOC:mah] | 4 | 4.614231e-03 | 0 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 28 | 4.670976e-03 | 0 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 26 | 6.463038e-03 | 0 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 28 | 8.574698e-03 | 0 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 56 | 1.008870e-02 | 0 |
| GO:MF | GO:0030234 | enzyme regulator activity | "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 33 | 1.012946e-02 | 0 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 226 | 1.749042e-02 | 0 |
| GO:MF | GO:0019903 | protein phosphatase binding | "Binding to a protein phosphatase." [GOC:jl] | 9 | 1.878645e-02 | 0 |
| GO:MF | GO:0042578 | phosphoric ester hydrolase activity | "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl] | 17 | 2.055238e-02 | 0 |
| GO:MF | GO:0005102 | signaling receptor binding | "Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] | 35 | 2.306180e-02 | 0 |
| GO:MF | GO:0045309 | protein phosphorylated amino acid binding | "Binding to a phosphorylated amino acid residue within a protein." [GOC:go_curators] | 6 | 2.382077e-02 | 0 |
| GO:MF | GO:0005109 | frizzled binding | "Binding to a frizzled (fz) receptor." [GOC:ceb] | 5 | 2.539104e-02 | 0 |
| GO:MF | GO:0019902 | phosphatase binding | "Binding to a phosphatase." [GOC:jl] | 10 | 3.023417e-02 | 0 |
| GO:MF | GO:0106310 | protein serine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989] | 14 | 3.039991e-02 | 0 |
| GO:MF | GO:0017124 | SH3 domain binding | "Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018] | 8 | 3.207149e-02 | 0 |
| GO:MF | GO:0005096 | GTPase activator activity | "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] | 12 | 3.404482e-02 | 0 |
| GO:MF | GO:0051010 | microtubule plus-end binding | "Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] | 4 | 3.594850e-02 | 0 |
| GO:MF | GO:0051219 | phosphoprotein binding | "Binding to a phosphorylated protein." [GOC:ai] | 7 | 4.013324e-02 | 0 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 31 | 4.110620e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 13 | 3.567664e-14 | 0 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 83 | 8.594308e-14 | 0 |
| REAC | REAC:R-HSA-195721 | Signaling by WNT | Signaling by WNT | 25 | 1.618186e-09 | 0 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 14 | 4.482192e-09 | 0 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 36 | 4.768279e-09 | 0 |
| REAC | REAC:R-HSA-196299 | Beta-catenin phosphorylation cascade | Beta-catenin phosphorylation cascade | 8 | 1.176159e-08 | 0 |
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 34 | 5.337797e-08 | 0 |
| REAC | REAC:R-HSA-8854518 | AURKA Activation by TPX2 | AURKA Activation by TPX2 | 12 | 1.036911e-07 | 0 |
| REAC | REAC:R-HSA-201681 | TCF dependent signaling in response to WNT | TCF dependent signaling in response to WNT | 19 | 2.246348e-07 | 0 |
| REAC | REAC:R-HSA-4791275 | Signaling by WNT in cancer | Signaling by WNT in cancer | 9 | 2.797438e-07 | 0 |
| REAC | REAC:R-HSA-380259 | Loss of Nlp from mitotic centrosomes | Loss of Nlp from mitotic centrosomes | 11 | 9.713894e-07 | 0 |
| REAC | REAC:R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | Loss of proteins required for interphase microtubule organization from the centrosome | 11 | 9.713894e-07 | 0 |
| REAC | REAC:R-HSA-380287 | Centrosome maturation | Centrosome maturation | 11 | 5.743382e-06 | 0 |
| REAC | REAC:R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | Recruitment of mitotic centrosome proteins and complexes | 11 | 5.743382e-06 | 0 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 16 | 6.303122e-06 | 0 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 16 | 7.285533e-06 | 0 |
| REAC | REAC:R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | Signaling by CTNNB1 phospho-site mutants | 6 | 1.331413e-05 | 0 |
| REAC | REAC:R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | CTNNB1 T41 mutants aren't phosphorylated | 6 | 1.331413e-05 | 0 |
| REAC | REAC:R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | CTNNB1 S37 mutants aren't phosphorylated | 6 | 1.331413e-05 | 0 |
| REAC | REAC:R-HSA-5339716 | Signaling by GSK3beta mutants | Signaling by GSK3beta mutants | 6 | 1.331413e-05 | 0 |
| REAC | REAC:R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | CTNNB1 S33 mutants aren't phosphorylated | 6 | 1.331413e-05 | 0 |
| REAC | REAC:R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | CTNNB1 S45 mutants aren't phosphorylated | 6 | 1.331413e-05 | 0 |
| REAC | REAC:R-HSA-111465 | Apoptotic cleavage of cellular proteins | Apoptotic cleavage of cellular proteins | 8 | 1.471174e-05 | 0 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 11 | 3.196023e-05 | 0 |
| REAC | REAC:R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | Anchoring of the basal body to the plasma membrane | 11 | 3.984932e-05 | 0 |
| REAC | REAC:R-HSA-68877 | Mitotic Prometaphase | Mitotic Prometaphase | 15 | 5.606088e-05 | 0 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 14 | 7.252492e-05 | 0 |
| REAC | REAC:R-HSA-75153 | Apoptotic execution phase | Apoptotic execution phase | 8 | 2.053406e-04 | 0 |
| REAC | REAC:R-HSA-180024 | DARPP-32 events | DARPP-32 events | 6 | 2.446282e-04 | 0 |
| REAC | REAC:R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | APC truncation mutants have impaired AXIN binding | 5 | 3.914079e-04 | 0 |
| REAC | REAC:R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | AXIN missense mutants destabilize the destruction complex | 5 | 3.914079e-04 | 0 |
| REAC | REAC:R-HSA-4839735 | Signaling by AXIN mutants | Signaling by AXIN mutants | 5 | 3.914079e-04 | 0 |
| REAC | REAC:R-HSA-4839748 | Signaling by AMER1 mutants | Signaling by AMER1 mutants | 5 | 3.914079e-04 | 0 |
| REAC | REAC:R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | Truncations of AMER1 destabilize the destruction complex | 5 | 3.914079e-04 | 0 |
| REAC | REAC:R-HSA-4839744 | Signaling by APC mutants | Signaling by APC mutants | 5 | 3.914079e-04 | 0 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 21 | 4.319203e-04 | 0 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 14 | 5.550976e-04 | 0 |
| REAC | REAC:R-HSA-9696264 | RND3 GTPase cycle | RND3 GTPase cycle | 7 | 7.140196e-04 | 0 |
| REAC | REAC:R-HSA-195253 | Degradation of beta-catenin by the destruction complex | Degradation of beta-catenin by the destruction complex | 9 | 9.739419e-04 | 0 |
| REAC | REAC:R-HSA-5628897 | TP53 Regulates Metabolic Genes | TP53 Regulates Metabolic Genes | 9 | 1.077827e-03 | 0 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 6 | 1.326320e-03 | 0 |
| REAC | REAC:R-HSA-446728 | Cell junction organization | Cell junction organization | 10 | 1.859544e-03 | 0 |
| REAC | REAC:R-HSA-3858494 | Beta-catenin independent WNT signaling | Beta-catenin independent WNT signaling | 11 | 2.212950e-03 | 0 |
| REAC | REAC:R-HSA-199991 | Membrane Trafficking | Membrane Trafficking | 24 | 2.713126e-03 | 0 |
| REAC | REAC:R-HSA-1500931 | Cell-Cell communication | Cell-Cell communication | 11 | 3.505971e-03 | 0 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 25 | 3.544436e-03 | 0 |
| REAC | REAC:R-HSA-195258 | RHO GTPase Effectors | RHO GTPase Effectors | 16 | 4.253751e-03 | 0 |
| REAC | REAC:R-HSA-9696273 | RND1 GTPase cycle | RND1 GTPase cycle | 6 | 1.019246e-02 | 0 |
| REAC | REAC:R-HSA-9696270 | RND2 GTPase cycle | RND2 GTPase cycle | 6 | 1.170861e-02 | 0 |
| REAC | REAC:R-HSA-9759475 | Regulation of CDH11 Expression and Function | Regulation of CDH11 Expression and Function | 5 | 1.361196e-02 | 0 |
| REAC | REAC:R-HSA-111447 | Activation of BAD and translocation to mitochondria | Activation of BAD and translocation to mitochondria | 4 | 1.908508e-02 | 0 |
| REAC | REAC:R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | Regulation of Expression and Function of Type II Classical Cadherins | 5 | 2.322292e-02 | 0 |
| REAC | REAC:R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | Regulation of Homotypic Cell-Cell Adhesion | 5 | 2.322292e-02 | 0 |
| REAC | REAC:R-HSA-9012999 | RHO GTPase cycle | RHO GTPase cycle | 18 | 2.485745e-02 | 0 |
| REAC | REAC:R-HSA-5653656 | Vesicle-mediated transport | Vesicle-mediated transport | 24 | 2.691894e-02 | 0 |
| REAC | REAC:R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | CDH11 homotypic and heterotypic interactions | 3 | 3.835206e-02 | 0 |
| REAC | REAC:R-HSA-9764302 | Regulation of CDH19 Expression and Function | Regulation of CDH19 Expression and Function | 3 | 3.835206e-02 | 0 |
| REAC | REAC:R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | COPI-independent Golgi-to-ER retrograde traffic | 6 | 3.926474e-02 | 0 |
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 6 | 4.366422e-02 | 0 |
| REAC | REAC:R-HSA-418990 | Adherens junctions interactions | Adherens junctions interactions | 6 | 4.844665e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP363 | Wnt signaling NetPath | Wnt signaling NetPath | 11 | 1.346519e-08 | 0 |
| WP | WP:WP5376 | 17p13 3 YWHAE copy number variation | 17p13 3 YWHAE copy number variation | 8 | 7.589032e-08 | 0 |
| WP | WP:WP4258 | lncRNA in canonical Wnt signaling and colorectal cancer | lncRNA in canonical Wnt signaling and colorectal cancer | 13 | 3.718465e-07 | 0 |
| WP | WP:WP3664 | Regulation of Wnt B catenin signaling by small molecule compounds | Regulation of Wnt B catenin signaling by small molecule compounds | 7 | 5.276284e-07 | 0 |
| WP | WP:WP399 | Wnt signaling and pluripotency | Wnt signaling and pluripotency | 13 | 5.459567e-07 | 0 |
| WP | WP:WP428 | Wnt signaling | Wnt signaling | 13 | 2.497051e-06 | 0 |
| WP | WP:WP5087 | Pleural mesothelioma | Pleural mesothelioma | 24 | 5.194487e-06 | 0 |
| WP | WP:WP5529 | Wnt Beta catenin signaling and ARTD family members | Wnt Beta catenin signaling and ARTD family members | 6 | 9.558657e-06 | 0 |
| WP | WP:WP4262 | Breast cancer pathway | Breast cancer pathway | 14 | 1.404963e-05 | 0 |
| WP | WP:WP4336 | ncRNAs in Wnt signaling in hepatocellular carcinoma | ncRNAs in Wnt signaling in hepatocellular carcinoma | 11 | 1.465366e-05 | 0 |
| WP | WP:WP4560 | MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement | MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement | 6 | 3.415877e-05 | 0 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 17 | 6.634969e-05 | 0 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 24 | 8.563952e-05 | 0 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 17 | 8.696830e-05 | 0 |
| WP | WP:WP3680 | Physico chemical features and toxicity associated pathways | Physico chemical features and toxicity associated pathways | 9 | 1.117279e-04 | 0 |
| WP | WP:WP4872 | MAP3K1 role in promoting and blocking gonadal determination | MAP3K1 role in promoting and blocking gonadal determination | 5 | 7.866508e-04 | 0 |
| WP | WP:WP4155 | Endometrial cancer | Endometrial cancer | 8 | 8.487716e-04 | 0 |
| WP | WP:WP2571 | Polycystic kidney disease pathway | Polycystic kidney disease pathway | 9 | 8.839512e-04 | 0 |
| WP | WP:WP2380 | Brain derived neurotrophic factor BDNF signaling | Brain derived neurotrophic factor BDNF signaling | 11 | 1.295952e-03 | 0 |
| WP | WP:WP4150 | Wnt signaling in kidney disease | Wnt signaling in kidney disease | 6 | 2.867989e-03 | 0 |
| WP | WP:WP4141 | PI3K AKT mTOR vitamin D3 signaling | PI3K AKT mTOR vitamin D3 signaling | 5 | 3.150730e-03 | 0 |
| WP | WP:WP2064 | Neural crest differentiation | Neural crest differentiation | 9 | 4.040593e-03 | 0 |
| WP | WP:WP5353 | Macrophage stimulating protein MSP signaling | Macrophage stimulating protein MSP signaling | 9 | 6.924591e-03 | 0 |
| WP | WP:WP710 | DNA damage response only ATM dependent | DNA damage response only ATM dependent | 9 | 7.452632e-03 | 0 |
| WP | WP:WP3658 | Wnt beta catenin signaling in leukemia | Wnt beta catenin signaling in leukemia | 5 | 7.497977e-03 | 0 |
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 9 | 9.245998e-03 | 0 |
| WP | WP:WP3931 | Embryonic stem cell pluripotency pathways | Embryonic stem cell pluripotency pathways | 9 | 1.304362e-02 | 0 |
| WP | WP:WP5502 | 16p13 11 copy number variation syndrome | 16p13 11 copy number variation syndrome | 5 | 1.305372e-02 | 0 |
| WP | WP:WP2572 | Primary focal segmental glomerulosclerosis FSGS | Primary focal segmental glomerulosclerosis FSGS | 7 | 2.005868e-02 | 0 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 7 | 2.191075e-02 | 0 |
| WP | WP:WP5475 | Hallmark of cancer sustaining proliferative signaling | Hallmark of cancer sustaining proliferative signaling | 8 | 2.217425e-02 | 0 |
| WP | WP:WP481 | Insulin signaling | Insulin signaling | 10 | 2.945528e-02 | 0 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 17 | 4.871955e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-139-5p | hsa-mir-139-5p | hsa-mir-139-5p | 41 | 2.433313e-07 | 0 |
| MIRNA | MIRNA:hsa-mir-200a | hsa-mir-200a | hsa-mir-200a | 51 | 6.525982e-07 | 0 |
| MIRNA | MIRNA:hsa-mir-141 | hsa-mir-141 | hsa-mir-141 | 51 | 6.525982e-07 | 0 |
| MIRNA | MIRNA:hsa-mir-548ah | hsa-mir-548ah | hsa-mir-548ah | 50 | 2.745631e-06 | 0 |
| MIRNA | MIRNA:hsa-mir-4666-3p | hsa-mir-4666-3p | hsa-mir-4666-3p | 49 | 6.151676e-06 | 0 |
| MIRNA | MIRNA:hsa-mir-582-5p | hsa-mir-582-5p | hsa-mir-582-5p | 47 | 8.421746e-06 | 0 |
| MIRNA | MIRNA:hsa-mir-3609 | hsa-mir-3609 | hsa-mir-3609 | 51 | 9.004131e-06 | 0 |
| MIRNA | MIRNA:hsa-mir-548z | hsa-mir-548z | hsa-mir-548z | 55 | 2.189535e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-548ac | hsa-mir-548ac | hsa-mir-548ac | 55 | 2.189535e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-548d-3p | hsa-mir-548d-3p | hsa-mir-548d-3p | 55 | 2.401185e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-330-3p | hsa-mir-330-3p | hsa-mir-330-3p | 48 | 3.391963e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-15a | hsa-mir-15a | hsa-mir-15a | 57 | 5.277477e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-497 | hsa-mir-497 | hsa-mir-497 | 57 | 5.277477e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-15b | hsa-mir-15b | hsa-mir-15b | 57 | 5.277477e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-424 | hsa-mir-424 | hsa-mir-424 | 57 | 5.277477e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-195 | hsa-mir-195 | hsa-mir-195 | 57 | 5.277477e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-16 | hsa-mir-16 | hsa-mir-16 | 57 | 5.277477e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 42 | 8.909784e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-4698 | hsa-mir-4698 | hsa-mir-4698 | 56 | 1.205410e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-3942-3p | hsa-mir-3942-3p | hsa-mir-3942-3p | 46 | 1.454414e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-524-5p | hsa-mir-524-5p | hsa-mir-524-5p | 57 | 2.744215e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-520d-5p | hsa-mir-520d-5p | hsa-mir-520d-5p | 57 | 2.787858e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-664 | hsa-mir-664 | hsa-mir-664 | 41 | 3.385110e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-548am | hsa-mir-548am | hsa-mir-548am | 51 | 3.393057e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-548x | hsa-mir-548x | hsa-mir-548x | 51 | 3.393057e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-548ae | hsa-mir-548ae | hsa-mir-548ae | 51 | 3.393057e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-548aj | hsa-mir-548aj | hsa-mir-548aj | 51 | 3.393057e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-3065-5p | hsa-mir-3065-5p | hsa-mir-3065-5p | 45 | 4.510700e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-3163 | hsa-mir-3163 | hsa-mir-3163 | 64 | 4.647546e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-4753-3p | hsa-mir-4753-3p | hsa-mir-4753-3p | 49 | 4.761807e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-3613-3p | hsa-mir-3613-3p | hsa-mir-3613-3p | 70 | 5.004690e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-300 | hsa-mir-300 | hsa-mir-300 | 43 | 5.421923e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-144 | hsa-mir-144 | hsa-mir-144 | 44 | 5.858550e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-381 | hsa-mir-381 | hsa-mir-381 | 42 | 6.252924e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-107 | hsa-mir-107 | hsa-mir-107 | 47 | 6.507377e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-3160-5p | hsa-mir-3160-5p | hsa-mir-3160-5p | 36 | 7.345343e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-1290 | hsa-mir-1290 | hsa-mir-1290 | 35 | 7.785334e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 32 | 1.059471e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-362-5p | hsa-mir-362-5p | hsa-mir-362-5p | 26 | 1.285044e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-103a | hsa-mir-103a | hsa-mir-103a | 44 | 1.341396e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-500b | hsa-mir-500b | hsa-mir-500b | 25 | 1.379558e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-4311 | hsa-mir-4311 | hsa-mir-4311 | 43 | 1.459739e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-3614-5p | hsa-mir-3614-5p | hsa-mir-3614-5p | 42 | 1.610541e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-3942-5p | hsa-mir-3942-5p | hsa-mir-3942-5p | 32 | 1.677344e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-4703-5p | hsa-mir-4703-5p | hsa-mir-4703-5p | 32 | 1.754734e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-410 | hsa-mir-410 | hsa-mir-410 | 36 | 1.918933e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-4668-5p | hsa-mir-4668-5p | hsa-mir-4668-5p | 52 | 1.938718e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-203 | hsa-mir-203 | hsa-mir-203 | 43 | 2.422595e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-93-5p | hsa-mir-93-5p | hsa-mir-93-5p | 36 | 2.488822e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-548c-3p | hsa-mir-548c-3p | hsa-mir-548c-3p | 73 | 2.606937e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-4276 | hsa-mir-4276 | hsa-mir-4276 | 37 | 2.713936e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-4796-3p | hsa-mir-4796-3p | hsa-mir-4796-3p | 41 | 2.771960e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-503 | hsa-mir-503 | hsa-mir-503 | 29 | 3.284599e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-7 | hsa-mir-7 | hsa-mir-7 | 37 | 3.412561e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-548aa | hsa-mir-548aa | hsa-mir-548aa | 46 | 3.667502e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-548ag | hsa-mir-548ag | hsa-mir-548ag | 29 | 3.691110e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-548ai | hsa-mir-548ai | hsa-mir-548ai | 29 | 3.691110e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-4328 | hsa-mir-4328 | hsa-mir-4328 | 48 | 4.398580e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-101 | hsa-mir-101 | hsa-mir-101 | 39 | 4.460274e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-4445 | hsa-mir-4445 | hsa-mir-4445 | 22 | 4.539623e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-374b | hsa-mir-374b | hsa-mir-374b | 36 | 5.688132e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-374a | hsa-mir-374a | hsa-mir-374a | 36 | 5.688132e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-4756-3p | hsa-mir-4756-3p | hsa-mir-4756-3p | 39 | 5.809132e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-610 | hsa-mir-610 | hsa-mir-610 | 23 | 6.010281e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-3714 | hsa-mir-3714 | hsa-mir-3714 | 47 | 6.869718e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-527 | hsa-mir-527 | hsa-mir-527 | 40 | 6.909550e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-545 | hsa-mir-545 | hsa-mir-545 | 45 | 7.054798e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-518a-5p | hsa-mir-518a-5p | hsa-mir-518a-5p | 40 | 7.146508e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-577 | hsa-mir-577 | hsa-mir-577 | 33 | 7.472684e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-19b | hsa-mir-19b | hsa-mir-19b | 36 | 7.639367e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-19a | hsa-mir-19a | hsa-mir-19a | 36 | 7.639367e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-3919 | hsa-mir-3919 | hsa-mir-3919 | 46 | 8.052771e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-142-5p | hsa-mir-142-5p | hsa-mir-142-5p | 39 | 8.059599e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-4677-5p | hsa-mir-4677-5p | hsa-mir-4677-5p | 33 | 8.080824e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-340 | hsa-mir-340 | hsa-mir-340 | 43 | 8.450670e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-92b | hsa-mir-92b | hsa-mir-92b | 37 | 9.303094e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-367 | hsa-mir-367 | hsa-mir-367 | 37 | 9.303094e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-363 | hsa-mir-363 | hsa-mir-363 | 37 | 9.303094e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-25 | hsa-mir-25 | hsa-mir-25 | 37 | 9.303094e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-32 | hsa-mir-32 | hsa-mir-32 | 37 | 9.303094e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-92a | hsa-mir-92a | hsa-mir-92a | 37 | 9.303094e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-3692 | hsa-mir-3692 | hsa-mir-3692 | 37 | 1.015370e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3148 | hsa-mir-3148 | hsa-mir-3148 | 54 | 1.030957e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-488 | hsa-mir-488 | hsa-mir-488 | 34 | 1.040718e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4307 | hsa-mir-4307 | hsa-mir-4307 | 42 | 1.095511e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-513a-5p | hsa-mir-513a-5p | hsa-mir-513a-5p | 48 | 1.157422e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-299-5p | hsa-mir-299-5p | hsa-mir-299-5p | 24 | 1.169692e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3973 | hsa-mir-3973 | hsa-mir-3973 | 39 | 1.245574e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-579 | hsa-mir-579 | hsa-mir-579 | 49 | 1.316615e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-548b-3p | hsa-mir-548b-3p | hsa-mir-548b-3p | 27 | 1.501635e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3124-3p | hsa-mir-3124-3p | hsa-mir-3124-3p | 41 | 1.582066e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3685 | hsa-mir-3685 | hsa-mir-3685 | 31 | 1.744258e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4427 | hsa-mir-4427 | hsa-mir-4427 | 32 | 1.790204e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-2276 | hsa-mir-2276 | hsa-mir-2276 | 33 | 1.818546e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4282 | hsa-mir-4282 | hsa-mir-4282 | 54 | 1.863857e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-1324 | hsa-mir-1324 | hsa-mir-1324 | 39 | 1.867757e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4511 | hsa-mir-4511 | hsa-mir-4511 | 31 | 1.883617e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-9 | hsa-mir-9 | hsa-mir-9 | 31 | 2.364971e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3646 | hsa-mir-3646 | hsa-mir-3646 | 48 | 2.783999e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-1910 | hsa-mir-1910 | hsa-mir-1910 | 29 | 3.025945e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-106b-5p | hsa-mir-106b-5p | hsa-mir-106b-5p | 31 | 3.181314e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 21 | 3.296702e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4801 | hsa-mir-4801 | hsa-mir-4801 | 39 | 3.374907e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4731-3p | hsa-mir-4731-3p | hsa-mir-4731-3p | 39 | 3.426552e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3158-5p | hsa-mir-3158-5p | hsa-mir-3158-5p | 39 | 3.426552e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-543 | hsa-mir-543 | hsa-mir-543 | 41 | 3.464798e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-326 | hsa-mir-326 | hsa-mir-326 | 37 | 3.466767e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4680-3p | hsa-mir-4680-3p | hsa-mir-4680-3p | 33 | 3.691082e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-1285 | hsa-mir-1285 | hsa-mir-1285 | 45 | 3.774249e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-570 | hsa-mir-570 | hsa-mir-570 | 47 | 4.056476e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3119 | hsa-mir-3119 | hsa-mir-3119 | 33 | 4.089513e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4527 | hsa-mir-4527 | hsa-mir-4527 | 22 | 4.160683e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3064-5p | hsa-mir-3064-5p | hsa-mir-3064-5p | 35 | 4.161354e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-513c | hsa-mir-513c | hsa-mir-513c | 32 | 4.255878e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-646 | hsa-mir-646 | hsa-mir-646 | 41 | 4.367312e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4672 | hsa-mir-4672 | hsa-mir-4672 | 40 | 4.536292e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4719 | hsa-mir-4719 | hsa-mir-4719 | 45 | 4.556635e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-548m | hsa-mir-548m | hsa-mir-548m | 29 | 4.600775e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-371-5p | hsa-mir-371-5p | hsa-mir-371-5p | 45 | 4.617855e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-324-3p | hsa-mir-324-3p | hsa-mir-324-3p | 40 | 4.948388e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4652-3p | hsa-mir-4652-3p | hsa-mir-4652-3p | 41 | 4.965027e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M02036 | Factor: WT1; motif: CGCCCCCNCN | Factor: WT1; motif: CGCCCCCNCN | 165 | 2.761318e-07 | 0 |
| TF | TF:M07208 | Factor: EGR1; motif: NCNCCGCCCCCGCN | Factor: EGR1; motif: NCNCCGCCCCCGCN | 121 | 4.403321e-07 | 0 |
| TF | TF:M01873 | Factor: Egr-1; motif: GCGGGGGCGG | Factor: Egr-1; motif: GCGGGGGCGG | 127 | 9.277561e-07 | 0 |
| TF | TF:M01219 | Factor: SP1:SP3; motif: CCSCCCCCYCC | Factor: SP1:SP3; motif: CCSCCCCCYCC | 128 | 9.767577e-07 | 0 |
| TF | TF:M10108 | Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG | Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG | 123 | 3.390038e-06 | 0 |
| TF | TF:M00695_1 | Factor: ETF; motif: GVGGMGG; match class: 1 | Factor: ETF; motif: GVGGMGG; match class: 1 | 129 | 4.021187e-06 | 0 |
| TF | TF:M12722_1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | 124 | 4.720955e-06 | 0 |
| TF | TF:M03893 | Factor: WT1; motif: GNGGGGGCGGGG | Factor: WT1; motif: GNGGGGGCGGGG | 144 | 7.198283e-06 | 0 |
| TF | TF:M01219_1 | Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1 | Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1 | 71 | 7.805298e-06 | 0 |
| TF | TF:M12703_1 | Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1 | Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1 | 91 | 2.142704e-05 | 0 |
| TF | TF:M09636_1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | 204 | 4.090397e-05 | 0 |
| TF | TF:M02089 | Factor: E2F-3; motif: GGCGGGN | Factor: E2F-3; motif: GGCGGGN | 195 | 5.412460e-05 | 0 |
| TF | TF:M11529_1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | 207 | 7.416735e-05 | 0 |
| TF | TF:M13144_1 | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS; match class: 1 | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS; match class: 1 | 103 | 8.731663e-05 | 0 |
| TF | TF:M10026 | Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN | Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN | 140 | 1.138167e-04 | 0 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 165 | 1.324335e-04 | 0 |
| TF | TF:M02036_1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | 102 | 1.464960e-04 | 0 |
| TF | TF:M13127_1 | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1 | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1 | 141 | 1.631470e-04 | 0 |
| TF | TF:M10108_1 | Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG; match class: 1 | Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG; match class: 1 | 66 | 1.804157e-04 | 0 |
| TF | TF:M13129_1 | Factor: RERE; motif: CNGCNSCNNGSRCRGSGSS; match class: 1 | Factor: RERE; motif: CNGCNSCNNGSRCRGSGSS; match class: 1 | 108 | 2.012096e-04 | 0 |
| TF | TF:M08867_1 | Factor: AP2; motif: GCCYGSGGSN; match class: 1 | Factor: AP2; motif: GCCYGSGGSN; match class: 1 | 99 | 2.538919e-04 | 0 |
| TF | TF:M02089_1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | 152 | 3.327051e-04 | 0 |
| TF | TF:M07039 | Factor: ETF; motif: CCCCGCCCCYN | Factor: ETF; motif: CCCCGCCCCYN | 221 | 3.770119e-04 | 0 |
| TF | TF:M01199_1 | Factor: RNF96; motif: BCCCGCRGCC; match class: 1 | Factor: RNF96; motif: BCCCGCRGCC; match class: 1 | 87 | 3.895017e-04 | 0 |
| TF | TF:M09723 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | 159 | 3.953115e-04 | 0 |
| TF | TF:M10086_1 | Factor: TAFII250; motif: RARRWGGCGGMGGNGR; match class: 1 | Factor: TAFII250; motif: RARRWGGCGGMGGNGR; match class: 1 | 81 | 5.787207e-04 | 0 |
| TF | TF:M11529 | Factor: E2F-2; motif: GCGCGCGCNCS | Factor: E2F-2; motif: GCGCGCGCNCS | 220 | 6.034833e-04 | 0 |
| TF | TF:M09984 | Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG | Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG | 153 | 6.470781e-04 | 0 |
| TF | TF:M11531 | Factor: E2F-2; motif: GCGCGCGCGYW | Factor: E2F-2; motif: GCGCGCGCGYW | 193 | 6.980249e-04 | 0 |
| TF | TF:M12722 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS | 164 | 8.695008e-04 | 0 |
| TF | TF:M07395 | Factor: Sp1; motif: NGGGGCGGGGN | Factor: Sp1; motif: NGGGGCGGGGN | 165 | 9.324203e-04 | 0 |
| TF | TF:M01104_1 | Factor: MOVO-B; motif: GNGGGGG; match class: 1 | Factor: MOVO-B; motif: GNGGGGG; match class: 1 | 104 | 9.515337e-04 | 0 |
| TF | TF:M04953 | Factor: Sp1; motif: GGNDGGRGGCGGGG | Factor: Sp1; motif: GGNDGGRGGCGGGG | 142 | 9.903338e-04 | 0 |
| TF | TF:M13128 | Factor: MED8; motif: CYYNSCYYCCTSCNCC | Factor: MED8; motif: CYYNSCYYCCTSCNCC | 187 | 1.174184e-03 | 0 |
| TF | TF:M00196 | Factor: Sp1; motif: NGGGGGCGGGGYN | Factor: Sp1; motif: NGGGGGCGGGGYN | 160 | 1.347198e-03 | 0 |
| TF | TF:M09826 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | 175 | 1.453513e-03 | 0 |
| TF | TF:M07354 | Factor: Egr-1; motif: GCGGGGGCGG | Factor: Egr-1; motif: GCGGGGGCGG | 132 | 1.642312e-03 | 0 |
| TF | TF:M12703 | Factor: ZNF383; motif: SSNGGGMGGNGSNGGS | Factor: ZNF383; motif: SSNGGGMGGNGSNGGS | 146 | 1.685370e-03 | 0 |
| TF | TF:M09826_1 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 | 129 | 1.801378e-03 | 0 |
| TF | TF:M07329 | Factor: Osx; motif: CCNCCCCCNNN | Factor: Osx; motif: CCNCCCCCNNN | 118 | 2.336552e-03 | 0 |
| TF | TF:M09761 | Factor: EGR1; motif: NGNGKGGGYGGNGS | Factor: EGR1; motif: NGNGKGGGYGGNGS | 96 | 2.414182e-03 | 0 |
| TF | TF:M10432 | Factor: MAZ; motif: GGGMGGGGS | Factor: MAZ; motif: GGGMGGGGS | 148 | 2.497146e-03 | 0 |
| TF | TF:M09898 | Factor: Egr-2; motif: GNGRRNGWGKGGGNGGRG | Factor: Egr-2; motif: GNGRRNGWGKGGGNGGRG | 113 | 3.550111e-03 | 0 |
| TF | TF:M07040_1 | Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1 | Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1 | 134 | 3.588515e-03 | 0 |
| TF | TF:M02023 | Factor: MAZ; motif: NKGGGAGGGGRGGR | Factor: MAZ; motif: NKGGGAGGGGRGGR | 121 | 3.987925e-03 | 0 |
| TF | TF:M07354_1 | Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 | Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 | 74 | 4.697335e-03 | 0 |
| TF | TF:M07039_1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | 194 | 4.907855e-03 | 0 |
| TF | TF:M11601 | Factor: TCF-1; motif: ACATCGRGRCGCTGW | Factor: TCF-1; motif: ACATCGRGRCGCTGW | 205 | 5.532331e-03 | 0 |
| TF | TF:M08878 | Factor: EGR; motif: CGCCCCCGCNN | Factor: EGR; motif: CGCCCCCGCNN | 125 | 5.547791e-03 | 0 |
| TF | TF:M11601_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 167 | 5.623081e-03 | 0 |
| TF | TF:M13366 | Factor: ZBED4; motif: CCCGCYCCGC | Factor: ZBED4; motif: CCCGCYCCGC | 127 | 6.230958e-03 | 0 |
| TF | TF:M08867 | Factor: AP2; motif: GCCYGSGGSN | Factor: AP2; motif: GCCYGSGGSN | 155 | 6.262043e-03 | 0 |
| TF | TF:M00982 | Factor: KROX; motif: CCCGCCCCCRCCCC | Factor: KROX; motif: CCCGCCCCCRCCCC | 129 | 6.336477e-03 | 0 |
| TF | TF:M01199 | Factor: RNF96; motif: BCCCGCRGCC | Factor: RNF96; motif: BCCCGCRGCC | 137 | 6.582605e-03 | 0 |
| TF | TF:M11603_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 189 | 6.735379e-03 | 0 |
| TF | TF:M10072_1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | 109 | 6.742228e-03 | 0 |
| TF | TF:M01865 | Factor: BTEB3; motif: BNRNGGGAGGNGT | Factor: BTEB3; motif: BNRNGGGAGGNGT | 153 | 6.917081e-03 | 0 |
| TF | TF:M12351_1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | 132 | 7.210126e-03 | 0 |
| TF | TF:M08911 | Factor: CTCF; motif: NCCRSTAGGGGGCGC | Factor: CTCF; motif: NCCRSTAGGGGGCGC | 144 | 7.236148e-03 | 0 |
| TF | TF:M10112 | Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR | Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR | 139 | 7.906798e-03 | 0 |
| TF | TF:M08441 | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG | 218 | 8.489190e-03 | 0 |
| TF | TF:M08441_1 | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 | 184 | 9.085178e-03 | 0 |
| TF | TF:M01104 | Factor: MOVO-B; motif: GNGGGGG | Factor: MOVO-B; motif: GNGGGGG | 157 | 9.885290e-03 | 0 |
| TF | TF:M05432 | Factor: ZSCAN18; motif: TRRCGRCGNMCC | Factor: ZSCAN18; motif: TRRCGRCGNMCC | 79 | 1.057981e-02 | 0 |
| TF | TF:M00915 | Factor: AP-2; motif: SNNNCCNCAGGCN | Factor: AP-2; motif: SNNNCCNCAGGCN | 149 | 1.252314e-02 | 0 |
| TF | TF:M00986_1 | Factor: Churchill; motif: CGGGNN; match class: 1 | Factor: Churchill; motif: CGGGNN; match class: 1 | 158 | 1.416044e-02 | 0 |
| TF | TF:M07289_1 | Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1 | Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1 | 160 | 1.494889e-02 | 0 |
| TF | TF:M03567 | Factor: Sp2; motif: NYSGCCCCGCCCCCY | Factor: Sp2; motif: NYSGCCCCGCCCCCY | 126 | 1.556468e-02 | 0 |
| TF | TF:M11603 | Factor: TCF-1; motif: ACATCGRGRCGCTGW | Factor: TCF-1; motif: ACATCGRGRCGCTGW | 217 | 1.760140e-02 | 0 |
| TF | TF:M12313 | Factor: ZNF460; motif: NNACNCCCCCCNN | Factor: ZNF460; motif: NNACNCCCCCCNN | 102 | 1.770544e-02 | 0 |
| TF | TF:M10072 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | 159 | 1.958271e-02 | 0 |
| TF | TF:M13124 | Factor: ZNF670; motif: SNGGGCRGRG | Factor: ZNF670; motif: SNGGGCRGRG | 183 | 2.030420e-02 | 0 |
| TF | TF:M12742 | Factor: ZNF93; motif: GGYAGCRGCAGCGGYG | Factor: ZNF93; motif: GGYAGCRGCAGCGGYG | 55 | 2.197441e-02 | 0 |
| TF | TF:M10086 | Factor: TAFII250; motif: RARRWGGCGGMGGNGR | Factor: TAFII250; motif: RARRWGGCGGMGGNGR | 141 | 2.245666e-02 | 0 |
| TF | TF:M07277 | Factor: BTEB2; motif: RGGGNGKGGN | Factor: BTEB2; motif: RGGGNGKGGN | 135 | 2.252476e-02 | 0 |
| TF | TF:M10026_1 | Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN; match class: 1 | Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN; match class: 1 | 88 | 2.333267e-02 | 0 |
| TF | TF:M01303 | Factor: SP1; motif: GGGGYGGGGNS | Factor: SP1; motif: GGGGYGGGGNS | 128 | 2.434649e-02 | 0 |
| TF | TF:M00931 | Factor: Sp1; motif: GGGGCGGGGC | Factor: Sp1; motif: GGGGCGGGGC | 156 | 2.506717e-02 | 0 |
| TF | TF:M09894 | Factor: E2F-4; motif: SNGGGCGGGAANN | Factor: E2F-4; motif: SNGGGCGGGAANN | 216 | 2.598855e-02 | 0 |
| TF | TF:M09984_1 | Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1 | Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1 | 98 | 2.666071e-02 | 0 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 221 | 2.764900e-02 | 0 |
| TF | TF:M10071_1 | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 | 85 | 2.936296e-02 | 0 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 205 | 2.954152e-02 | 0 |
| TF | TF:M03893_1 | Factor: WT1; motif: GNGGGGGCGGGG; match class: 1 | Factor: WT1; motif: GNGGGGGCGGGG; match class: 1 | 76 | 2.994224e-02 | 0 |
| TF | TF:M07226_1 | Factor: SP1; motif: NCCCCKCCCCC; match class: 1 | Factor: SP1; motif: NCCCCKCCCCC; match class: 1 | 75 | 3.218885e-02 | 0 |
| TF | TF:M09636 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG | 216 | 3.304000e-02 | 0 |
| TF | TF:M12351 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | 177 | 3.314912e-02 | 0 |
| TF | TF:M07208_1 | Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 | Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 | 49 | 3.557824e-02 | 0 |
| TF | TF:M09723_1 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 | 103 | 3.598480e-02 | 0 |
| TF | TF:M11531_1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | 178 | 3.655269e-02 | 0 |
| TF | TF:M13144 | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS | 145 | 3.659033e-02 | 0 |
| TF | TF:M12598_1 | Factor: E2F3; motif: NNRGMKGGAR; match class: 1 | Factor: E2F3; motif: NNRGMKGGAR; match class: 1 | 115 | 3.730347e-02 | 0 |
| TF | TF:M12158 | Factor: KLF15; motif: NCCMCGCCCMCN | Factor: KLF15; motif: NCCMCGCCCMCN | 157 | 4.026108e-02 | 0 |
| TF | TF:M08911_1 | Factor: CTCF; motif: NCCRSTAGGGGGCGC; match class: 1 | Factor: CTCF; motif: NCCRSTAGGGGGCGC; match class: 1 | 75 | 4.213477e-02 | 0 |
| TF | TF:M10098 | Factor: DP-1; motif: NRNNGGCGGGAANN | Factor: DP-1; motif: NRNNGGCGGGAANN | 116 | 4.478588e-02 | 0 |
| TF | TF:M07084_1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | 95 | 4.809453e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 148 | 0.000002 | 0 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 148 | 0.000014 | 0 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 148 | 0.000014 | 0 |
| HPA | HPA:0050000 | Breast | Breast | 146 | 0.000015 | 0 |
| HPA | HPA:0130052 | Colon; glandular cells[≥Medium] | Colon; glandular cells[≥Medium] | 129 | 0.000023 | 0 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 147 | 0.000024 | 0 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 147 | 0.000024 | 0 |
| HPA | HPA:0130051 | Colon; glandular cells[≥Low] | Colon; glandular cells[≥Low] | 143 | 0.000025 | 0 |
| HPA | HPA:0400051 | Rectum; glandular cells[≥Low] | Rectum; glandular cells[≥Low] | 143 | 0.000058 | 0 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 148 | 0.000078 | 0 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 147 | 0.000101 | 0 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 147 | 0.000110 | 0 |
| HPA | HPA:0030051 | Appendix; glandular cells[≥Low] | Appendix; glandular cells[≥Low] | 138 | 0.000115 | 0 |
| HPA | HPA:0380000 | Placenta | Placenta | 148 | 0.000139 | 0 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 138 | 0.000240 | 0 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 139 | 0.000358 | 0 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 121 | 0.000385 | 0 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 148 | 0.000428 | 0 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 148 | 0.000428 | 0 |
| HPA | HPA:0150051 | Duodenum; glandular cells[≥Low] | Duodenum; glandular cells[≥Low] | 141 | 0.000586 | 0 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 145 | 0.000592 | 0 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 151 | 0.000661 | 0 |
| HPA | HPA:0480051 | Small intestine; glandular cells[≥Low] | Small intestine; glandular cells[≥Low] | 140 | 0.000983 | 0 |
| HPA | HPA:0340000 | Ovary | Ovary | 116 | 0.001051 | 0 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 121 | 0.001079 | 0 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 119 | 0.001440 | 0 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 153 | 0.001473 | 0 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 140 | 0.001649 | 0 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 140 | 0.001649 | 0 |
| HPA | HPA:0130241 | Colon; peripheral nerve/ganglion[≥Low] | Colon; peripheral nerve/ganglion[≥Low] | 109 | 0.001860 | 0 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 147 | 0.001892 | 0 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 147 | 0.001892 | 0 |
| HPA | HPA:0400000 | Rectum | Rectum | 151 | 0.002018 | 0 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 117 | 0.002330 | 0 |
| HPA | HPA:0030000 | Appendix | Appendix | 149 | 0.002402 | 0 |
| HPA | HPA:0480052 | Small intestine; glandular cells[≥Medium] | Small intestine; glandular cells[≥Medium] | 124 | 0.003245 | 0 |
| HPA | HPA:0130000 | Colon | Colon | 155 | 0.003471 | 0 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 140 | 0.003590 | 0 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 117 | 0.003981 | 0 |
| HPA | HPA:0290000 | Liver | Liver | 127 | 0.004151 | 0 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 115 | 0.004380 | 0 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 101 | 0.005311 | 0 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 140 | 0.005865 | 0 |
| HPA | HPA:0100212 | Cerebral cortex; neuropil[≥Medium] | Cerebral cortex; neuropil[≥Medium] | 66 | 0.006133 | 0 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 135 | 0.007005 | 0 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 135 | 0.007005 | 0 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 118 | 0.007027 | 0 |
| HPA | HPA:0130242 | Colon; peripheral nerve/ganglion[≥Medium] | Colon; peripheral nerve/ganglion[≥Medium] | 80 | 0.009013 | 0 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 145 | 0.010170 | 0 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 145 | 0.010170 | 0 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 113 | 0.010233 | 0 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 148 | 0.011539 | 0 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 133 | 0.013723 | 0 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 133 | 0.013723 | 0 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 93 | 0.013964 | 0 |
| HPA | HPA:0130202 | Colon; endothelial cells[≥Medium] | Colon; endothelial cells[≥Medium] | 84 | 0.016077 | 0 |
| HPA | HPA:0150052 | Duodenum; glandular cells[≥Medium] | Duodenum; glandular cells[≥Medium] | 122 | 0.018441 | 0 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 131 | 0.019717 | 0 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 130 | 0.023680 | 0 |
| HPA | HPA:0390000 | Prostate | Prostate | 130 | 0.023680 | 0 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 124 | 0.027692 | 0 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 105 | 0.028250 | 0 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 119 | 0.029991 | 0 |
| HPA | HPA:0460651 | Skin 1; fibroblasts[≥Low] | Skin 1; fibroblasts[≥Low] | 89 | 0.032020 | 0 |
| HPA | HPA:0270000 | Kidney | Kidney | 151 | 0.033834 | 0 |
| HPA | HPA:0400052 | Rectum; glandular cells[≥Medium] | Rectum; glandular cells[≥Medium] | 121 | 0.034786 | 0 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 129 | 0.035855 | 0 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 113 | 0.041364 | 0 |
| HPA | HPA:0460661 | Skin 1; keratinocytes[≥Low] | Skin 1; keratinocytes[≥Low] | 106 | 0.042914 | 0 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 129 | 0.047001 | 0 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 129 | 0.047001 | 0 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 105 | 0.048930 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5177 | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | 5 | 0.000029 | 0 |
| CORUM | CORUM:4151 | TSC (TSC1, TSC2, AXIN, GSK3) complex | TSC (TSC1, TSC2, AXIN, GSK3) complex | 4 | 0.000062 | 0 |
| CORUM | CORUM:6353 | beta-Catenin destruction complex | beta-Catenin destruction complex | 3 | 0.002629 | 0 |
| CORUM | CORUM:3166 | AXIN1-APC-CTNNB1-GSK3B complex | AXIN1-APC-CTNNB1-GSK3B complex | 3 | 0.002629 | 0 |
| CORUM | CORUM:6963 | AXIN1-GID8-GSK3B complex | AXIN1-GID8-GSK3B complex | 3 | 0.002629 | 0 |
| CORUM | CORUM:2998 | Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex | Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex | 3 | 0.010331 | 0 |
| CORUM | CORUM:7159 | TSC2-GSK3-AXIN-DVL complex | TSC2-GSK3-AXIN-DVL complex | 3 | 0.010331 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0200040 | Epidermoid cyst | Nontender, round and firm, but slightly compressible, intradermal or subcutaneous cyst measuring 0.5-5 cm in diameter. Epidermal cysts are intradermal or subcutaneous tumors, grow slowly and occur on the face, neck, back and scrotum. They usually appear at or around puberty, and as a rule an affected individual has one solitary or a few cysts. | 5 | 0.018174 | 0 |
| HP | HP:0002862 | Bladder carcinoma | The presence of a carcinoma of the urinary bladder. | 6 | 0.022853 | 0 |
| HP | HP:0009725 | Bladder neoplasm | The presence of a neoplasm of the urinary bladder. | 6 | 0.027381 | 0 |
| HP | HP:0011044 | Abnormal number of permanent teeth | The presence of an altered number of of permanent teeth. | 6 | 0.032607 | 0 |
| HP | HP:0000006 | Autosomal dominant inheritance | A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. | 52 | 0.038091 | 0 |
| HP | HP:0005584 | Renal cell carcinoma | A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule. | 8 | 0.039443 | 0 |
| HP | HP:0006483 | Abnormal number of teeth | The presence of an altered number of of teeth. | 19 | 0.039528 | 0 |
| HP | HP:0001442 | Typified by somatic mosaicism | Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic. | 12 | 0.040377 | 0 |
| HP | HP:0006349 | Agenesis of permanent teeth | A congenital defect characterized by the absence of one or more permanent teeth, including oligodontia, hypodontia, and adontia of the of permanent teeth. | 5 | 0.049890 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 139 | 1.018692e-46 | 1 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 175 | 2.110277e-34 | 1 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 76 | 2.865964e-28 | 1 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 76 | 2.956202e-28 | 1 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 76 | 2.956202e-28 | 1 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 75 | 7.977690e-28 | 1 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 101 | 1.038963e-27 | 1 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 79 | 2.976048e-18 | 1 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 85 | 4.003245e-15 | 1 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 48 | 4.310389e-15 | 1 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 28 | 1.566156e-13 | 1 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 60 | 5.086152e-13 | 1 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 60 | 2.254908e-12 | 1 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 60 | 2.507953e-12 | 1 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 44 | 4.075506e-12 | 1 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 104 | 4.135019e-12 | 1 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 104 | 4.135019e-12 | 1 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 104 | 4.135019e-12 | 1 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 11 | 5.709695e-12 | 1 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 177 | 1.187976e-10 | 1 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 14 | 1.509614e-10 | 1 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 14 | 1.509614e-10 | 1 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 166 | 7.782562e-10 | 1 |
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 46 | 1.053190e-09 | 1 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 32 | 1.890937e-09 | 1 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 34 | 1.990865e-09 | 1 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 34 | 2.441828e-09 | 1 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 29 | 7.735812e-09 | 1 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 79 | 1.257200e-08 | 1 |
| GO:CC | GO:0005832 | chaperonin-containing T-complex | "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] | 6 | 1.612057e-08 | 1 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 43 | 1.777341e-08 | 1 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 170 | 1.962426e-08 | 1 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 12 | 1.234207e-07 | 1 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 17 | 3.937881e-07 | 1 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 17 | 4.969557e-07 | 1 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 69 | 5.069727e-07 | 1 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 17 | 5.203677e-07 | 1 |
| GO:CC | GO:0044297 | cell body | "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] | 21 | 2.411107e-06 | 1 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 79 | 7.092221e-06 | 1 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 12 | 1.108066e-05 | 1 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 161 | 1.129937e-05 | 1 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 89 | 1.150750e-05 | 1 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 89 | 1.159638e-05 | 1 |
| GO:CC | GO:0022624 | proteasome accessory complex | "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] | 6 | 1.228581e-05 | 1 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 45 | 1.741767e-05 | 1 |
| GO:CC | GO:0000502 | proteasome complex | "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome] | 8 | 2.099654e-05 | 1 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 28 | 2.268100e-05 | 1 |
| GO:CC | GO:0005819 | spindle | "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] | 17 | 3.487414e-05 | 1 |
| GO:CC | GO:0016234 | inclusion body | "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744] | 8 | 4.151552e-05 | 1 |
| GO:CC | GO:0048471 | perinuclear region of cytoplasm | "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] | 22 | 5.649871e-05 | 1 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 24 | 7.126859e-05 | 1 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 98 | 8.244273e-05 | 1 |
| GO:CC | GO:0002199 | zona pellucida receptor complex | "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] | 4 | 8.568448e-05 | 1 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 13 | 1.376884e-04 | 1 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 149 | 2.165686e-04 | 1 |
| GO:CC | GO:0005838 | proteasome regulatory particle | "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 5 | 2.349152e-04 | 1 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 23 | 4.035008e-04 | 1 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 12 | 4.234858e-04 | 1 |
| GO:CC | GO:1905369 | endopeptidase complex | "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 8 | 5.144889e-04 | 1 |
| GO:CC | GO:0008540 | proteasome regulatory particle, base subcomplex | "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 4 | 5.906674e-04 | 1 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 113 | 6.397416e-04 | 1 |
| GO:CC | GO:0072686 | mitotic spindle | "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] | 10 | 8.634508e-04 | 1 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 13 | 9.054369e-04 | 1 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 41 | 1.348079e-03 | 1 |
| GO:CC | GO:0140534 | endoplasmic reticulum protein-containing complex | "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] | 8 | 1.458461e-03 | 1 |
| GO:CC | GO:0045121 | membrane raft | "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567] | 12 | 1.685889e-03 | 1 |
| GO:CC | GO:0098857 | membrane microdomain | "A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it." [PMID:20044567, PMID:26253820] | 12 | 1.805593e-03 | 1 |
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 7 | 2.824104e-03 | 1 |
| GO:CC | GO:0099522 | cytosolic region | "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos] | 5 | 3.066890e-03 | 1 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 19 | 3.365976e-03 | 1 |
| GO:CC | GO:1905368 | peptidase complex | "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 8 | 3.385914e-03 | 1 |
| GO:CC | GO:0043025 | neuronal cell body | "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] | 15 | 4.560720e-03 | 1 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 109 | 5.058413e-03 | 1 |
| GO:CC | GO:0005775 | vacuolar lumen | "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] | 9 | 5.108709e-03 | 1 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 21 | 5.197910e-03 | 1 |
| GO:CC | GO:0000323 | lytic vacuole | "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] | 19 | 5.226328e-03 | 1 |
| GO:CC | GO:0005764 | lysosome | "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] | 19 | 5.226328e-03 | 1 |
| GO:CC | GO:0150034 | distal axon | "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] | 11 | 5.956587e-03 | 1 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 38 | 5.992313e-03 | 1 |
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 15 | 6.290090e-03 | 1 |
| GO:CC | GO:0005773 | vacuole | "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] | 20 | 8.139931e-03 | 1 |
| GO:CC | GO:0031967 | organelle envelope | "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] | 26 | 8.448870e-03 | 1 |
| GO:CC | GO:0042582 | azurophil granule | "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule] | 8 | 1.207096e-02 | 1 |
| GO:CC | GO:0005766 | primary lysosome | "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] | 8 | 1.207096e-02 | 1 |
| GO:CC | GO:0005952 | cAMP-dependent protein kinase complex | "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [PMID:18178622] | 3 | 1.273004e-02 | 1 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 13 | 1.439080e-02 | 1 |
| GO:CC | GO:0031594 | neuromuscular junction | "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] | 6 | 1.440123e-02 | 1 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 13 | 1.821579e-02 | 1 |
| GO:CC | GO:1990565 | HSP90-CDC37 chaperone complex | "A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." [GOC:bhm, GOC:pad, GOC:PARL, PMID:21855797, PMID:22939624] | 2 | 1.954779e-02 | 1 |
| GO:CC | GO:0017177 | glucosidase II complex | "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335] | 2 | 1.954779e-02 | 1 |
| GO:CC | GO:1902687 | glucosidase complex | "A protein complex which is capable of glucosidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932] | 2 | 1.954779e-02 | 1 |
| GO:CC | GO:0034515 | proteasome storage granule | "An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:krc, GOC:rb, PMID:18504300, PMID:30204036] | 2 | 1.954779e-02 | 1 |
| GO:CC | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane | "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] | 5 | 2.087930e-02 | 1 |
| GO:CC | GO:0005768 | endosome | "A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] | 22 | 2.137243e-02 | 1 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 29 | 2.307285e-02 | 1 |
| GO:CC | GO:0005929 | cilium | "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] | 18 | 2.411648e-02 | 1 |
| GO:CC | GO:0034663 | endoplasmic reticulum chaperone complex | "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] | 3 | 2.470726e-02 | 1 |
| GO:CC | GO:0030424 | axon | "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] | 16 | 2.990446e-02 | 1 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 7 | 4.294613e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 112 | 3.101467e-27 | 1 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 25 | 8.463170e-18 | 1 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 69 | 1.386581e-17 | 1 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 69 | 1.486525e-17 | 1 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 17 | 9.185571e-17 | 1 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 59 | 2.048837e-16 | 1 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 41 | 1.677260e-15 | 1 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 43 | 2.107158e-15 | 1 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 32 | 7.986223e-15 | 1 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 58 | 2.648214e-14 | 1 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 58 | 2.906984e-14 | 1 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 83 | 8.131261e-14 | 1 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 69 | 1.255751e-13 | 1 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 66 | 1.760150e-13 | 1 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 71 | 2.179187e-13 | 1 |
| GO:BP | GO:0006458 | 'de novo' protein folding | "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] | 13 | 2.355098e-13 | 1 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 55 | 5.996359e-13 | 1 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 29 | 6.089196e-13 | 1 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 81 | 6.194986e-13 | 1 |
| GO:BP | GO:0009408 | response to heat | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] | 16 | 6.662050e-13 | 1 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 62 | 9.548257e-13 | 1 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 53 | 1.481902e-12 | 1 |
| GO:BP | GO:0051084 | 'de novo' post-translational protein folding | "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] | 12 | 2.412578e-12 | 1 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 76 | 3.171035e-12 | 1 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 129 | 6.316493e-12 | 1 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 39 | 6.964598e-12 | 1 |
| GO:BP | GO:0034605 | cellular response to heat | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] | 13 | 1.767319e-11 | 1 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 54 | 2.544815e-11 | 1 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 46 | 2.992889e-11 | 1 |
| GO:BP | GO:0006753 | nucleoside phosphate metabolic process | "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] | 30 | 7.049113e-11 | 1 |
| GO:BP | GO:1900182 | positive regulation of protein localization to nucleus | "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 14 | 1.410796e-10 | 1 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 37 | 1.505935e-10 | 1 |
| GO:BP | GO:0009266 | response to temperature stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] | 17 | 2.006169e-10 | 1 |
| GO:BP | GO:0055086 | nucleobase-containing small molecule metabolic process | "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] | 30 | 2.043527e-10 | 1 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 44 | 2.163562e-10 | 1 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 16 | 2.594437e-10 | 1 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 37 | 2.627082e-10 | 1 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 73 | 3.586162e-10 | 1 |
| GO:BP | GO:0006914 | autophagy | "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464] | 28 | 4.322800e-10 | 1 |
| GO:BP | GO:0061919 | process utilizing autophagic mechanism | "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] | 28 | 4.322800e-10 | 1 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 34 | 5.147472e-10 | 1 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 64 | 5.391885e-10 | 1 |
| GO:BP | GO:0035966 | response to topologically incorrect protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] | 16 | 8.134700e-10 | 1 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 36 | 1.006176e-09 | 1 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 46 | 1.211982e-09 | 1 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 42 | 1.482441e-09 | 1 |
| GO:BP | GO:0030162 | regulation of proteolysis | "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] | 23 | 1.540608e-09 | 1 |
| GO:BP | GO:0009117 | nucleotide metabolic process | "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] | 25 | 1.698620e-09 | 1 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 31 | 1.910049e-09 | 1 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 21 | 2.364949e-09 | 1 |
| GO:BP | GO:1901698 | response to nitrogen compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 36 | 3.116181e-09 | 1 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] | 23 | 3.255901e-09 | 1 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 109 | 4.567371e-09 | 1 |
| GO:BP | GO:0072521 | purine-containing compound metabolic process | "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 26 | 4.788554e-09 | 1 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 32 | 5.665940e-09 | 1 |
| GO:BP | GO:0009141 | nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 19 | 5.754524e-09 | 1 |
| GO:BP | GO:0006468 | protein phosphorylation | "The process of introducing a phosphate group on to a protein." [GOC:hb] | 38 | 6.220155e-09 | 1 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 42 | 7.006163e-09 | 1 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 20 | 7.892793e-09 | 1 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 62 | 8.131697e-09 | 1 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 74 | 9.426596e-09 | 1 |
| GO:BP | GO:0016236 | macroautophagy | "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339] | 21 | 1.037677e-08 | 1 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 39 | 1.286586e-08 | 1 |
| GO:BP | GO:1901652 | response to peptide | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] | 33 | 1.429209e-08 | 1 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 49 | 1.593827e-08 | 1 |
| GO:BP | GO:0009628 | response to abiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] | 36 | 1.635441e-08 | 1 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 37 | 1.794445e-08 | 1 |
| GO:BP | GO:0051086 | chaperone mediated protein folding independent of cofactor | "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] | 6 | 1.851054e-08 | 1 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 90 | 1.996669e-08 | 1 |
| GO:BP | GO:0009199 | ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 18 | 2.009982e-08 | 1 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 97 | 2.117853e-08 | 1 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 51 | 2.944752e-08 | 1 |
| GO:BP | GO:0006986 | response to unfolded protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] | 14 | 3.219277e-08 | 1 |
| GO:BP | GO:0006163 | purine nucleotide metabolic process | "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 22 | 3.693189e-08 | 1 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 93 | 3.981161e-08 | 1 |
| GO:BP | GO:1903050 | regulation of proteolysis involved in protein catabolic process | "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 17 | 4.126393e-08 | 1 |
| GO:BP | GO:0034097 | response to cytokine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] | 32 | 4.597312e-08 | 1 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 39 | 5.030138e-08 | 1 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 17 | 5.040821e-08 | 1 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 58 | 5.239713e-08 | 1 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 33 | 5.348383e-08 | 1 |
| GO:BP | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 6 | 5.513770e-08 | 1 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 58 | 6.242143e-08 | 1 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 17 | 6.992448e-08 | 1 |
| GO:BP | GO:0070201 | regulation of establishment of protein localization | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] | 24 | 7.061052e-08 | 1 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 87 | 7.800145e-08 | 1 |
| GO:BP | GO:0042026 | protein refolding | "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] | 8 | 8.829738e-08 | 1 |
| GO:BP | GO:0016241 | regulation of macroautophagy | "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] | 15 | 1.135638e-07 | 1 |
| GO:BP | GO:0009259 | ribonucleotide metabolic process | "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 20 | 1.338032e-07 | 1 |
| GO:BP | GO:1904869 | regulation of protein localization to Cajal body | "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 6 | 1.368665e-07 | 1 |
| GO:BP | GO:1904871 | positive regulation of protein localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 6 | 1.368665e-07 | 1 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 35 | 1.782000e-07 | 1 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 16 | 1.861806e-07 | 1 |
| GO:BP | GO:0009144 | purine nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 17 | 1.895771e-07 | 1 |
| GO:BP | GO:0019693 | ribose phosphate metabolic process | "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 20 | 1.952457e-07 | 1 |
| GO:BP | GO:0002376 | immune system process | "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] | 58 | 2.207555e-07 | 1 |
| GO:BP | GO:0019637 | organophosphate metabolic process | "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] | 33 | 2.788201e-07 | 1 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 62 | 3.070561e-07 | 1 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 88 | 3.252558e-07 | 1 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 90 | 3.417884e-07 | 1 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 25 | 4.311265e-07 | 1 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 25 | 5.072309e-07 | 1 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 23 | 5.354278e-07 | 1 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 145 | 5.902720e-07 | 1 |
| GO:BP | GO:1904872 | regulation of telomerase RNA localization to Cajal body | "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 6 | 5.937014e-07 | 1 |
| GO:BP | GO:1904867 | protein localization to Cajal body | "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 6 | 5.937014e-07 | 1 |
| GO:BP | GO:1903405 | protein localization to nuclear body | "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] | 6 | 5.937014e-07 | 1 |
| GO:BP | GO:0051234 | establishment of localization | "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] | 80 | 7.254496e-07 | 1 |
| GO:BP | GO:0010506 | regulation of autophagy | "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] | 19 | 7.760204e-07 | 1 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 64 | 8.217624e-07 | 1 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 64 | 9.052606e-07 | 1 |
| GO:BP | GO:0009205 | purine ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 16 | 1.123490e-06 | 1 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 65 | 1.200840e-06 | 1 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 30 | 1.231897e-06 | 1 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] | 15 | 1.233316e-06 | 1 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 30 | 1.262662e-06 | 1 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 33 | 1.426654e-06 | 1 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 24 | 1.681887e-06 | 1 |
| GO:BP | GO:0051131 | chaperone-mediated protein complex assembly | "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai] | 7 | 1.699170e-06 | 1 |
| GO:BP | GO:0032212 | positive regulation of telomere maintenance via telomerase | "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 7 | 1.699170e-06 | 1 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 141 | 1.848676e-06 | 1 |
| GO:BP | GO:0071345 | cellular response to cytokine stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah] | 28 | 1.868083e-06 | 1 |
| GO:BP | GO:1990173 | protein localization to nucleoplasm | "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] | 6 | 1.902265e-06 | 1 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 58 | 1.917604e-06 | 1 |
| GO:BP | GO:0006886 | intracellular protein transport | "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] | 25 | 1.928395e-06 | 1 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 32 | 2.243421e-06 | 1 |
| GO:BP | GO:0045184 | establishment of protein localization | "The directed movement of a protein to a specific location." [GOC:bf] | 44 | 2.349896e-06 | 1 |
| GO:BP | GO:0009150 | purine ribonucleotide metabolic process | "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 18 | 2.670069e-06 | 1 |
| GO:BP | GO:0061136 | regulation of proteasomal protein catabolic process | "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] | 14 | 3.072595e-06 | 1 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 14 | 3.072595e-06 | 1 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 40 | 3.167134e-06 | 1 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 38 | 3.613277e-06 | 1 |
| GO:BP | GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 12 | 4.006290e-06 | 1 |
| GO:BP | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 7 | 4.266321e-06 | 1 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 28 | 4.896055e-06 | 1 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 18 | 5.878500e-06 | 1 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 24 | 6.020794e-06 | 1 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 30 | 6.548477e-06 | 1 |
| GO:BP | GO:0051050 | positive regulation of transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 27 | 7.030171e-06 | 1 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] | 29 | 8.278443e-06 | 1 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 93 | 8.412202e-06 | 1 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 17 | 8.741636e-06 | 1 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 17 | 8.741636e-06 | 1 |
| GO:BP | GO:0002682 | regulation of immune system process | "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] | 38 | 9.065992e-06 | 1 |
| GO:BP | GO:0009605 | response to external stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] | 49 | 9.147197e-06 | 1 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | "The alteration of an amino acid residue in a peptide." [GOC:mah] | 24 | 9.530934e-06 | 1 |
| GO:BP | GO:1901135 | carbohydrate derivative metabolic process | "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] | 29 | 9.937451e-06 | 1 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 145 | 1.241502e-05 | 1 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 142 | 1.254327e-05 | 1 |
| GO:BP | GO:0007017 | microtubule-based process | "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] | 29 | 1.423460e-05 | 1 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 59 | 1.464606e-05 | 1 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 40 | 1.565693e-05 | 1 |
| GO:BP | GO:0090685 | RNA localization to nucleus | "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] | 6 | 1.658640e-05 | 1 |
| GO:BP | GO:0090672 | telomerase RNA localization | "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 6 | 1.658640e-05 | 1 |
| GO:BP | GO:0090670 | RNA localization to Cajal body | "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 6 | 1.658640e-05 | 1 |
| GO:BP | GO:0090671 | telomerase RNA localization to Cajal body | "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 6 | 1.658640e-05 | 1 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 20 | 1.687277e-05 | 1 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 21 | 1.842131e-05 | 1 |
| GO:BP | GO:0046034 | ATP metabolic process | "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] | 14 | 2.132758e-05 | 1 |
| GO:BP | GO:0072594 | establishment of protein localization to organelle | "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] | 23 | 2.264398e-05 | 1 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 15 | 2.287216e-05 | 1 |
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 12 | 2.927836e-05 | 1 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 12 | 2.927836e-05 | 1 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 27 | 2.967709e-05 | 1 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 107 | 3.407016e-05 | 1 |
| GO:BP | GO:0070585 | protein localization to mitochondrion | "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd] | 11 | 3.480890e-05 | 1 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 18 | 3.503692e-05 | 1 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] | 26 | 3.511150e-05 | 1 |
| GO:BP | GO:0045087 | innate immune response | "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] | 28 | 4.088535e-05 | 1 |
| GO:BP | GO:0051258 | protein polymerization | "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] | 15 | 4.489365e-05 | 1 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 12 | 4.700995e-05 | 1 |
| GO:BP | GO:1904951 | positive regulation of establishment of protein localization | "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] | 16 | 4.794064e-05 | 1 |
| GO:BP | GO:0006810 | transport | "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] | 70 | 5.147258e-05 | 1 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 96 | 5.361403e-05 | 1 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 22 | 5.509868e-05 | 1 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 12 | 5.719326e-05 | 1 |
| GO:BP | GO:0007165 | signal transduction | "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] | 86 | 6.081895e-05 | 1 |
| GO:BP | GO:0044281 | small molecule metabolic process | "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] | 39 | 6.490760e-05 | 1 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] | 12 | 6.503841e-05 | 1 |
| GO:BP | GO:0006952 | defense response | "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] | 40 | 6.634137e-05 | 1 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 23 | 6.670014e-05 | 1 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 73 | 7.072033e-05 | 1 |
| GO:BP | GO:0009607 | response to biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] | 37 | 7.198122e-05 | 1 |
| GO:BP | GO:0007005 | mitochondrion organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] | 18 | 7.444675e-05 | 1 |
| GO:BP | GO:0019752 | carboxylic acid metabolic process | "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] | 26 | 7.684208e-05 | 1 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 8 | 8.000947e-05 | 1 |
| GO:BP | GO:0016567 | protein ubiquitination | "The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419] | 24 | 8.213360e-05 | 1 |
| GO:BP | GO:1901800 | positive regulation of proteasomal protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] | 10 | 8.838065e-05 | 1 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 41 | 9.303770e-05 | 1 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 34 | 9.712823e-05 | 1 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 34 | 9.877351e-05 | 1 |
| GO:BP | GO:0070841 | inclusion body assembly | "The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah] | 6 | 1.037447e-04 | 1 |
| GO:BP | GO:0031400 | negative regulation of protein modification process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 16 | 1.085867e-04 | 1 |
| GO:BP | GO:0015031 | protein transport | "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 34 | 1.129103e-04 | 1 |
| GO:BP | GO:0046822 | regulation of nucleocytoplasmic transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] | 10 | 1.135783e-04 | 1 |
| GO:BP | GO:0051707 | response to other organism | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] | 36 | 1.183260e-04 | 1 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 8 | 1.184910e-04 | 1 |
| GO:BP | GO:0043207 | response to external biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] | 36 | 1.240366e-04 | 1 |
| GO:BP | GO:0043436 | oxoacid metabolic process | "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] | 26 | 1.248681e-04 | 1 |
| GO:BP | GO:0018209 | peptidyl-serine modification | "The modification of peptidyl-serine." [GOC:go_curators] | 12 | 1.359140e-04 | 1 |
| GO:BP | GO:0032386 | regulation of intracellular transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] | 14 | 1.397589e-04 | 1 |
| GO:BP | GO:0006082 | organic acid metabolic process | "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] | 26 | 1.421524e-04 | 1 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 33 | 1.435451e-04 | 1 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 37 | 1.466146e-04 | 1 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 107 | 1.597485e-04 | 1 |
| GO:BP | GO:0051640 | organelle localization | "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] | 21 | 1.615373e-04 | 1 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 90 | 1.631842e-04 | 1 |
| GO:BP | GO:0072655 | establishment of protein localization to mitochondrion | "The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah] | 10 | 1.983865e-04 | 1 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 45 | 2.077663e-04 | 1 |
| GO:BP | GO:0032210 | regulation of telomere maintenance via telomerase | "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 7 | 2.242174e-04 | 1 |
| GO:BP | GO:0009185 | ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 2.492080e-04 | 1 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 31 | 2.571401e-04 | 1 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] | 21 | 2.605562e-04 | 1 |
| GO:BP | GO:0050776 | regulation of immune response | "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 26 | 2.784226e-04 | 1 |
| GO:BP | GO:0140546 | defense response to symbiont | "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] | 28 | 2.965859e-04 | 1 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 89 | 3.029287e-04 | 1 |
| GO:BP | GO:0046785 | microtubule polymerization | "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] | 9 | 3.061936e-04 | 1 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 21 | 3.123140e-04 | 1 |
| GO:BP | GO:0031334 | positive regulation of protein-containing complex assembly | "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] | 12 | 3.171235e-04 | 1 |
| GO:BP | GO:0042325 | regulation of phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] | 24 | 3.453088e-04 | 1 |
| GO:BP | GO:0006606 | protein import into nucleus | "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] | 11 | 3.684905e-04 | 1 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 8 | 3.823934e-04 | 1 |
| GO:BP | GO:0002684 | positive regulation of immune system process | "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] | 28 | 4.077159e-04 | 1 |
| GO:BP | GO:0051085 | chaperone cofactor-dependent protein refolding | "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb] | 6 | 4.133140e-04 | 1 |
| GO:BP | GO:0009132 | nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 4.145549e-04 | 1 |
| GO:BP | GO:1903578 | regulation of ATP metabolic process | "Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] | 8 | 4.256361e-04 | 1 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] | 23 | 4.417443e-04 | 1 |
| GO:BP | GO:0051656 | establishment of organelle localization | "The directed movement of an organelle to a specific location." [GOC:ai] | 18 | 4.533205e-04 | 1 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 39 | 4.534983e-04 | 1 |
| GO:BP | GO:2000573 | positive regulation of DNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 7 | 4.678261e-04 | 1 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 11 | 4.686860e-04 | 1 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 8 | 4.730046e-04 | 1 |
| GO:BP | GO:0043434 | response to peptide hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] | 17 | 4.781980e-04 | 1 |
| GO:BP | GO:0045732 | positive regulation of protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] | 12 | 4.837192e-04 | 1 |
| GO:BP | GO:0051170 | import into nucleus | "The directed movement of substances into the nucleus." [GOC:ai] | 11 | 4.972232e-04 | 1 |
| GO:BP | GO:0071705 | nitrogen compound transport | "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] | 39 | 5.257324e-04 | 1 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 31 | 5.578685e-04 | 1 |
| GO:BP | GO:0022411 | cellular component disassembly | "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] | 17 | 5.782933e-04 | 1 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 151 | 5.831750e-04 | 1 |
| GO:BP | GO:0031109 | microtubule polymerization or depolymerization | "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] | 10 | 5.854129e-04 | 1 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 24 | 6.712419e-04 | 1 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 33 | 7.353929e-04 | 1 |
| GO:BP | GO:0035967 | cellular response to topologically incorrect protein | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] | 9 | 7.653332e-04 | 1 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 48 | 7.960610e-04 | 1 |
| GO:BP | GO:1904356 | regulation of telomere maintenance via telomere lengthening | "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 7 | 7.967068e-04 | 1 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 33 | 8.175906e-04 | 1 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 22 | 8.234194e-04 | 1 |
| GO:BP | GO:0022607 | cellular component assembly | "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] | 70 | 8.424962e-04 | 1 |
| GO:BP | GO:0046649 | lymphocyte activation | "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] | 23 | 9.517908e-04 | 1 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 15 | 1.005518e-03 | 1 |
| GO:BP | GO:1901293 | nucleoside phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie] | 14 | 1.054243e-03 | 1 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] | 14 | 1.095128e-03 | 1 |
| GO:BP | GO:0043933 | protein-containing complex organization | "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah] | 56 | 1.120554e-03 | 1 |
| GO:BP | GO:0032868 | response to insulin | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 13 | 1.143385e-03 | 1 |
| GO:BP | GO:1900542 | regulation of purine nucleotide metabolic process | "Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] | 8 | 1.144810e-03 | 1 |
| GO:BP | GO:1904375 | regulation of protein localization to cell periphery | "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] | 10 | 1.192135e-03 | 1 |
| GO:BP | GO:0006955 | immune response | "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add] | 40 | 1.252526e-03 | 1 |
| GO:BP | GO:0006140 | regulation of nucleotide metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] | 8 | 1.254596e-03 | 1 |
| GO:BP | GO:1901654 | response to ketone | "A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676] | 12 | 1.285330e-03 | 1 |
| GO:BP | GO:0051049 | regulation of transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 34 | 1.382097e-03 | 1 |
| GO:BP | GO:0033157 | regulation of intracellular protein transport | "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] | 10 | 1.432245e-03 | 1 |
| GO:BP | GO:0034330 | cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] | 23 | 1.446644e-03 | 1 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 82 | 1.493621e-03 | 1 |
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] | 17 | 1.512899e-03 | 1 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 24 | 1.730661e-03 | 1 |
| GO:BP | GO:0002764 | immune response-regulating signaling pathway | "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] | 18 | 1.798822e-03 | 1 |
| GO:BP | GO:0045321 | leukocyte activation | "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add] | 25 | 1.915924e-03 | 1 |
| GO:BP | GO:0098542 | defense response to other organism | "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] | 29 | 2.050943e-03 | 1 |
| GO:BP | GO:0032501 | multicellular organismal process | "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] | 94 | 2.147467e-03 | 1 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 19 | 2.205237e-03 | 1 |
| GO:BP | GO:0032271 | regulation of protein polymerization | "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 11 | 2.247256e-03 | 1 |
| GO:BP | GO:0045931 | positive regulation of mitotic cell cycle | "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 9 | 2.282262e-03 | 1 |
| GO:BP | GO:0006090 | pyruvate metabolic process | "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] | 9 | 2.282262e-03 | 1 |
| GO:BP | GO:0032273 | positive regulation of protein polymerization | "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 8 | 2.306214e-03 | 1 |
| GO:BP | GO:0001775 | cell activation | "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators] | 27 | 2.466617e-03 | 1 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 24 | 2.536987e-03 | 1 |
| GO:BP | GO:0009166 | nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] | 10 | 2.564851e-03 | 1 |
| GO:BP | GO:0051223 | regulation of protein transport | "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 16 | 2.571282e-03 | 1 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 20 | 2.840030e-03 | 1 |
| GO:BP | GO:0043086 | negative regulation of catalytic activity | "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] | 13 | 2.856905e-03 | 1 |
| GO:BP | GO:0006096 | glycolytic process | "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] | 8 | 2.946655e-03 | 1 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 18 | 3.015894e-03 | 1 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 18 | 3.015894e-03 | 1 |
| GO:BP | GO:0002253 | activation of immune response | "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] | 18 | 3.015894e-03 | 1 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 71 | 3.129721e-03 | 1 |
| GO:BP | GO:0007051 | spindle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] | 11 | 3.152110e-03 | 1 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] | 28 | 3.410580e-03 | 1 |
| GO:BP | GO:0046032 | ADP catabolic process | "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 8 | 3.452936e-03 | 1 |
| GO:BP | GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 9 | 3.612601e-03 | 1 |
| GO:BP | GO:0030705 | cytoskeleton-dependent intracellular transport | "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] | 11 | 3.628950e-03 | 1 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 26 | 3.766094e-03 | 1 |
| GO:BP | GO:1901875 | positive regulation of post-translational protein modification | "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 9 | 3.848678e-03 | 1 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 86 | 3.983072e-03 | 1 |
| GO:BP | GO:0019364 | pyridine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] | 8 | 4.031397e-03 | 1 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 45 | 4.161931e-03 | 1 |
| GO:BP | GO:0010563 | negative regulation of phosphorus metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 13 | 4.294288e-03 | 1 |
| GO:BP | GO:0045936 | negative regulation of phosphate metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 13 | 4.294288e-03 | 1 |
| GO:BP | GO:0001558 | regulation of cell growth | "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] | 15 | 4.335970e-03 | 1 |
| GO:BP | GO:0009181 | purine ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 4.350237e-03 | 1 |
| GO:BP | GO:0009137 | purine nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 4.350237e-03 | 1 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 61 | 4.481739e-03 | 1 |
| GO:BP | GO:0051222 | positive regulation of protein transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 12 | 4.485394e-03 | 1 |
| GO:BP | GO:0034975 | protein folding in endoplasmic reticulum | "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw] | 4 | 4.513348e-03 | 1 |
| GO:BP | GO:0080135 | regulation of cellular response to stress | "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 17 | 4.627419e-03 | 1 |
| GO:BP | GO:0072526 | pyridine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 8 | 5.052596e-03 | 1 |
| GO:BP | GO:0050807 | regulation of synapse organization | "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] | 13 | 5.137653e-03 | 1 |
| GO:BP | GO:0065003 | protein-containing complex assembly | "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl] | 52 | 5.375871e-03 | 1 |
| GO:BP | GO:0009191 | ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 5.438434e-03 | 1 |
| GO:BP | GO:0006195 | purine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 9 | 5.563834e-03 | 1 |
| GO:BP | GO:0006626 | protein targeting to mitochondrion | "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363] | 8 | 5.849004e-03 | 1 |
| GO:BP | GO:0046031 | ADP metabolic process | "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 8 | 5.849004e-03 | 1 |
| GO:BP | GO:0023056 | positive regulation of signaling | "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 35 | 6.049522e-03 | 1 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 8 | 6.285583e-03 | 1 |
| GO:BP | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 8 | 6.285583e-03 | 1 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] | 13 | 6.564713e-03 | 1 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 17 | 6.941413e-03 | 1 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 47 | 7.015567e-03 | 1 |
| GO:BP | GO:0009134 | nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 7.242138e-03 | 1 |
| GO:BP | GO:0016049 | cell growth | "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] | 16 | 8.461065e-03 | 1 |
| GO:BP | GO:1901292 | nucleoside phosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie] | 10 | 8.467846e-03 | 1 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] | 11 | 9.134545e-03 | 1 |
| GO:BP | GO:0034614 | cellular response to reactive oxygen species | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] | 9 | 9.353252e-03 | 1 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 14 | 9.836321e-03 | 1 |
| GO:BP | GO:2001234 | negative regulation of apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 11 | 9.921258e-03 | 1 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 8 | 1.018812e-02 | 1 |
| GO:BP | GO:0002757 | immune response-activating signaling pathway | "The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add] | 16 | 1.067061e-02 | 1 |
| GO:BP | GO:0044092 | negative regulation of molecular function | "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 17 | 1.075081e-02 | 1 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 14 | 1.076021e-02 | 1 |
| GO:BP | GO:0051646 | mitochondrion localization | "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] | 6 | 1.102548e-02 | 1 |
| GO:BP | GO:0090666 | scaRNA localization to Cajal body | "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 3 | 1.128347e-02 | 1 |
| GO:BP | GO:0032787 | monocarboxylic acid metabolic process | "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] | 18 | 1.135530e-02 | 1 |
| GO:BP | GO:0009135 | purine nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 1.322277e-02 | 1 |
| GO:BP | GO:0009179 | purine ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 1.322277e-02 | 1 |
| GO:BP | GO:0050808 | synapse organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] | 17 | 1.359794e-02 | 1 |
| GO:BP | GO:0044089 | positive regulation of cellular component biogenesis | "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 16 | 1.406443e-02 | 1 |
| GO:BP | GO:0072523 | purine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 9 | 1.440128e-02 | 1 |
| GO:BP | GO:0045088 | regulation of innate immune response | "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] | 15 | 1.463435e-02 | 1 |
| GO:BP | GO:0010647 | positive regulation of cell communication | "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 34 | 1.584004e-02 | 1 |
| GO:BP | GO:0050778 | positive regulation of immune response | "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 20 | 1.601607e-02 | 1 |
| GO:BP | GO:0000302 | response to reactive oxygen species | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] | 10 | 1.612891e-02 | 1 |
| GO:BP | GO:0006206 | pyrimidine nucleobase metabolic process | "The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] | 4 | 1.615540e-02 | 1 |
| GO:BP | GO:0006403 | RNA localization | "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] | 10 | 1.685356e-02 | 1 |
| GO:BP | GO:0051346 | negative regulation of hydrolase activity | "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] | 7 | 1.687960e-02 | 1 |
| GO:BP | GO:1905897 | regulation of response to endoplasmic reticulum stress | "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] | 7 | 1.687960e-02 | 1 |
| GO:BP | GO:0006734 | NADH metabolic process | "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] | 5 | 1.832422e-02 | 1 |
| GO:BP | GO:0009112 | nucleobase metabolic process | "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma] | 5 | 1.832422e-02 | 1 |
| GO:BP | GO:0051654 | establishment of mitochondrion localization | "The directed movement of the mitochondrion to a specific location." [GOC:ai] | 5 | 1.832422e-02 | 1 |
| GO:BP | GO:0071353 | cellular response to interleukin-4 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah] | 5 | 1.832422e-02 | 1 |
| GO:BP | GO:0019221 | cytokine-mediated signaling pathway | "The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629] | 16 | 1.929691e-02 | 1 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc] | 18 | 1.991041e-02 | 1 |
| GO:BP | GO:0042110 | T cell activation | "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149] | 17 | 2.093101e-02 | 1 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 13 | 2.098015e-02 | 1 |
| GO:BP | GO:0046112 | nucleobase biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] | 4 | 2.098521e-02 | 1 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 131 | 2.105050e-02 | 1 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 9 | 2.270871e-02 | 1 |
| GO:BP | GO:0032869 | cellular response to insulin stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 10 | 2.276046e-02 | 1 |
| GO:BP | GO:0072384 | organelle transport along microtubule | "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] | 7 | 2.280628e-02 | 1 |
| GO:BP | GO:0016242 | negative regulation of macroautophagy | "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] | 5 | 2.448475e-02 | 1 |
| GO:BP | GO:0002218 | activation of innate immune response | "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805] | 12 | 2.458522e-02 | 1 |
| GO:BP | GO:0042306 | regulation of protein import into nucleus | "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl] | 6 | 2.519805e-02 | 1 |
| GO:BP | GO:0032984 | protein-containing complex disassembly | "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] | 11 | 2.604575e-02 | 1 |
| GO:BP | GO:1901136 | carbohydrate derivative catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] | 11 | 2.604575e-02 | 1 |
| GO:BP | GO:0031929 | TOR signaling | "The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295] | 9 | 2.626049e-02 | 1 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 7 | 2.636025e-02 | 1 |
| GO:BP | GO:0071218 | cellular response to misfolded protein | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah] | 4 | 2.680084e-02 | 1 |
| GO:BP | GO:0007249 | canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217] | 12 | 2.710166e-02 | 1 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 46 | 2.763900e-02 | 1 |
| GO:BP | GO:0031344 | regulation of cell projection organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] | 18 | 2.770324e-02 | 1 |
| GO:BP | GO:0070670 | response to interleukin-4 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah] | 5 | 2.811508e-02 | 1 |
| GO:BP | GO:0010507 | negative regulation of autophagy | "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] | 7 | 2.830196e-02 | 1 |
| GO:BP | GO:0009154 | purine ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 2.886957e-02 | 1 |
| GO:BP | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626] | 9 | 2.888271e-02 | 1 |
| GO:BP | GO:0040007 | growth | "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] | 22 | 2.894763e-02 | 1 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 18 | 3.003593e-02 | 1 |
| GO:BP | GO:0034620 | cellular response to unfolded protein | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah] | 7 | 3.036042e-02 | 1 |
| GO:BP | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] | 8 | 3.054042e-02 | 1 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 76 | 3.081991e-02 | 1 |
| GO:BP | GO:0016477 | cell migration | "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] | 30 | 3.211250e-02 | 1 |
| GO:BP | GO:0040008 | regulation of growth | "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] | 17 | 3.369714e-02 | 1 |
| GO:BP | GO:0048311 | mitochondrion distribution | "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid] | 4 | 3.372114e-02 | 1 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] | 15 | 3.456628e-02 | 1 |
| GO:BP | GO:0062197 | cellular response to chemical stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] | 12 | 3.605187e-02 | 1 |
| GO:BP | GO:0046824 | positive regulation of nucleocytoplasmic transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] | 6 | 3.643844e-02 | 1 |
| GO:BP | GO:0051648 | vesicle localization | "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai] | 10 | 3.706741e-02 | 1 |
| GO:BP | GO:0002221 | pattern recognition receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] | 11 | 3.712546e-02 | 1 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 36 | 3.719366e-02 | 1 |
| GO:BP | GO:0090316 | positive regulation of intracellular protein transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] | 7 | 3.729143e-02 | 1 |
| GO:BP | GO:0007052 | mitotic spindle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah] | 8 | 3.806064e-02 | 1 |
| GO:BP | GO:0048312 | intracellular distribution of mitochondria | "Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid] | 3 | 3.899546e-02 | 1 |
| GO:BP | GO:0009260 | ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 9 | 3.989133e-02 | 1 |
| GO:BP | GO:0007339 | binding of sperm to zona pellucida | "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] | 5 | 4.156862e-02 | 1 |
| GO:BP | GO:0051788 | response to misfolded protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:go_curators] | 4 | 4.187014e-02 | 1 |
| GO:BP | GO:0051090 | regulation of DNA-binding transcription factor activity | "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] | 12 | 4.206138e-02 | 1 |
| GO:BP | GO:0009261 | ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 4.236816e-02 | 1 |
| GO:BP | GO:0010970 | transport along microtubule | "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] | 9 | 4.362494e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 135 | 3.673420e-27 | 1 |
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 18 | 5.957835e-27 | 1 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 74 | 1.421365e-22 | 1 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 64 | 1.738483e-22 | 1 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 76 | 3.793073e-22 | 1 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 76 | 6.081184e-22 | 1 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 71 | 6.478389e-22 | 1 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 19 | 5.900370e-21 | 1 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 70 | 1.116566e-20 | 1 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 69 | 1.204814e-20 | 1 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 60 | 1.301553e-20 | 1 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 70 | 1.767656e-20 | 1 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 76 | 1.784481e-20 | 1 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 59 | 2.027390e-20 | 1 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 72 | 6.657985e-18 | 1 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 28 | 1.246295e-17 | 1 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 73 | 3.856768e-17 | 1 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 28 | 5.817787e-17 | 1 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 17 | 1.201552e-13 | 1 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 174 | 5.868788e-13 | 1 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 66 | 1.734943e-11 | 1 |
| GO:MF | GO:0031072 | heat shock protein binding | "Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw] | 16 | 2.798288e-11 | 1 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 105 | 4.781684e-10 | 1 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 27 | 6.839959e-09 | 1 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 100 | 1.157713e-08 | 1 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 29 | 4.668991e-08 | 1 |
| GO:MF | GO:0106310 | protein serine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989] | 20 | 4.926304e-08 | 1 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 29 | 6.294085e-08 | 1 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 21 | 7.579732e-08 | 1 |
| GO:MF | GO:0016787 | hydrolase activity | "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] | 64 | 8.300099e-08 | 1 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 24 | 1.090806e-07 | 1 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 27 | 1.451887e-07 | 1 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 32 | 1.626717e-07 | 1 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 30 | 2.859532e-07 | 1 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 49 | 3.656743e-07 | 1 |
| GO:MF | GO:0016740 | transferase activity | "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-] | 54 | 5.740051e-07 | 1 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 36 | 7.337566e-07 | 1 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 35 | 9.299302e-07 | 1 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 35 | 9.494354e-07 | 1 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 35 | 9.494354e-07 | 1 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 34 | 1.006825e-06 | 1 |
| GO:MF | GO:0051787 | misfolded protein binding | "Binding to a misfolded protein." [GOC:ai] | 6 | 2.138547e-06 | 1 |
| GO:MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] | 33 | 2.272802e-06 | 1 |
| GO:MF | GO:0097718 | disordered domain specific binding | "Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698] | 7 | 3.271202e-06 | 1 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 23 | 1.303314e-05 | 1 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 32 | 1.725700e-05 | 1 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 180 | 5.127214e-05 | 1 |
| GO:MF | GO:0048156 | tau protein binding | "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] | 7 | 6.081384e-05 | 1 |
| GO:MF | GO:0051879 | Hsp90 protein binding | "Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai] | 7 | 7.177980e-05 | 1 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 15 | 2.134533e-04 | 1 |
| GO:MF | GO:0098772 | molecular function regulator activity | "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt] | 43 | 2.789999e-04 | 1 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 27 | 3.034075e-04 | 1 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 26 | 5.602231e-04 | 1 |
| GO:MF | GO:0016491 | oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-] | 22 | 7.160766e-04 | 1 |
| GO:MF | GO:0019902 | phosphatase binding | "Binding to a phosphatase." [GOC:jl] | 11 | 7.380903e-04 | 1 |
| GO:MF | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-] | 9 | 1.061079e-03 | 1 |
| GO:MF | GO:0030060 | L-malate dehydrogenase (NAD+) activity | "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [RHEA:21432] | 3 | 1.738352e-03 | 1 |
| GO:MF | GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] | 9 | 2.021817e-03 | 1 |
| GO:MF | GO:0051087 | protein-folding chaperone binding | "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443] | 9 | 2.021817e-03 | 1 |
| GO:MF | GO:0016874 | ligase activity | "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-] | 10 | 2.580800e-03 | 1 |
| GO:MF | GO:0051020 | GTPase binding | "Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai] | 13 | 3.479954e-03 | 1 |
| GO:MF | GO:0019903 | protein phosphatase binding | "Binding to a protein phosphatase." [GOC:jl] | 9 | 3.864192e-03 | 1 |
| GO:MF | GO:0008017 | microtubule binding | "Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc] | 12 | 5.366961e-03 | 1 |
| GO:MF | GO:0015631 | tubulin binding | "Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] | 14 | 7.295434e-03 | 1 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 17 | 7.731525e-03 | 1 |
| GO:MF | GO:0035591 | signaling adaptor activity | "The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498] | 8 | 8.091648e-03 | 1 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 25 | 1.410130e-02 | 1 |
| GO:MF | GO:0030235 | nitric-oxide synthase regulator activity | "Binds to and modulates the activity of nitric oxide synthase." [GOC:mah] | 3 | 1.491353e-02 | 1 |
| GO:MF | GO:0030911 | TPR domain binding | "Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah] | 3 | 1.491353e-02 | 1 |
| GO:MF | GO:0042803 | protein homodimerization activity | "Binding to an identical protein to form a homodimer." [GOC:jl] | 19 | 1.849372e-02 | 1 |
| GO:MF | GO:0016615 | malate dehydrogenase activity | "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089] | 3 | 2.370542e-02 | 1 |
| GO:MF | GO:0004712 | protein serine/threonine/tyrosine kinase activity | "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah] | 5 | 2.434329e-02 | 1 |
| GO:MF | GO:0030234 | enzyme regulator activity | "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 27 | 3.446658e-02 | 1 |
| GO:MF | GO:0023026 | MHC class II protein complex binding | "Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw] | 4 | 3.536073e-02 | 1 |
| GO:MF | GO:0005200 | structural constituent of cytoskeleton | "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] | 7 | 4.571219e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 105 | 1.418738e-13 | 1 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 108 | 2.327407e-12 | 1 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 104 | 4.806774e-12 | 1 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 127 | 3.915562e-11 | 1 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 136 | 3.939792e-11 | 1 |
| HPA | HPA:0340000 | Ovary | Ovary | 120 | 5.856848e-11 | 1 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 57 | 1.452215e-10 | 1 |
| HPA | HPA:0050000 | Breast | Breast | 138 | 6.059114e-10 | 1 |
| HPA | HPA:0530000 | Spleen | Spleen | 123 | 1.872724e-09 | 1 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 42 | 3.144260e-09 | 1 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 133 | 3.491619e-09 | 1 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 48 | 4.295650e-09 | 1 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 125 | 4.385101e-09 | 1 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 109 | 6.553196e-09 | 1 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 129 | 1.023364e-08 | 1 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 131 | 1.282136e-08 | 1 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 136 | 1.357189e-08 | 1 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 38 | 1.435404e-08 | 1 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 123 | 2.078165e-08 | 1 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 110 | 2.652106e-08 | 1 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 118 | 3.295147e-08 | 1 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 96 | 3.741044e-08 | 1 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 36 | 3.983570e-08 | 1 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 138 | 4.069096e-08 | 1 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 94 | 5.026394e-08 | 1 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 132 | 5.503431e-08 | 1 |
| HPA | HPA:0630000 | Cervix | Cervix | 132 | 5.987027e-08 | 1 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 36 | 6.290365e-08 | 1 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 38 | 7.058399e-08 | 1 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 137 | 7.328367e-08 | 1 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 41 | 8.073176e-08 | 1 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 137 | 8.087226e-08 | 1 |
| HPA | HPA:0030000 | Appendix | Appendix | 141 | 9.235468e-08 | 1 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 137 | 1.026571e-07 | 1 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 133 | 1.048495e-07 | 1 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 109 | 1.583467e-07 | 1 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 36 | 1.796408e-07 | 1 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 73 | 1.911535e-07 | 1 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 130 | 1.951811e-07 | 1 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 123 | 1.957836e-07 | 1 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 31 | 2.047774e-07 | 1 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 33 | 2.124881e-07 | 1 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 140 | 2.162733e-07 | 1 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 37 | 2.186780e-07 | 1 |
| HPA | HPA:0380000 | Placenta | Placenta | 137 | 3.065819e-07 | 1 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 82 | 3.190207e-07 | 1 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 135 | 3.706434e-07 | 1 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 135 | 3.706434e-07 | 1 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 105 | 3.814345e-07 | 1 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 99 | 4.600000e-07 | 1 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 111 | 5.050018e-07 | 1 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 102 | 5.136778e-07 | 1 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 36 | 6.050207e-07 | 1 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 127 | 6.059950e-07 | 1 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 121 | 7.812859e-07 | 1 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 105 | 7.941600e-07 | 1 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 110 | 8.631367e-07 | 1 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 108 | 8.730402e-07 | 1 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 130 | 8.890359e-07 | 1 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 142 | 9.357586e-07 | 1 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 135 | 9.366898e-07 | 1 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 114 | 1.012807e-06 | 1 |
| HPA | HPA:0130000 | Colon | Colon | 144 | 1.198675e-06 | 1 |
| HPA | HPA:0080000 | Caudate | Caudate | 130 | 1.202673e-06 | 1 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 30 | 1.259271e-06 | 1 |
| HPA | HPA:0130241 | Colon; peripheral nerve/ganglion[≥Low] | Colon; peripheral nerve/ganglion[≥Low] | 106 | 1.324846e-06 | 1 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 91 | 1.491125e-06 | 1 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 115 | 1.759874e-06 | 1 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 93 | 2.003250e-06 | 1 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 108 | 2.529272e-06 | 1 |
| HPA | HPA:0400000 | Rectum | Rectum | 140 | 2.611769e-06 | 1 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 83 | 3.288944e-06 | 1 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 35 | 3.352471e-06 | 1 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 117 | 3.583687e-06 | 1 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 32 | 3.683647e-06 | 1 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 139 | 3.755671e-06 | 1 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 113 | 4.471869e-06 | 1 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 128 | 5.068963e-06 | 1 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 128 | 5.068963e-06 | 1 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 109 | 5.149261e-06 | 1 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 30 | 7.421946e-06 | 1 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 131 | 7.763068e-06 | 1 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 132 | 8.672829e-06 | 1 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 132 | 8.672829e-06 | 1 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 29 | 8.706288e-06 | 1 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 93 | 9.600399e-06 | 1 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 106 | 1.156147e-05 | 1 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 101 | 1.182876e-05 | 1 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 27 | 1.228026e-05 | 1 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 131 | 1.292635e-05 | 1 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 30 | 1.443062e-05 | 1 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 115 | 1.446110e-05 | 1 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 116 | 1.964738e-05 | 1 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 55 | 2.126339e-05 | 1 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 124 | 2.213610e-05 | 1 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 124 | 2.213610e-05 | 1 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 28 | 2.306071e-05 | 1 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 135 | 2.364994e-05 | 1 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 135 | 2.364994e-05 | 1 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 90 | 2.425816e-05 | 1 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 129 | 2.694648e-05 | 1 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 129 | 2.694648e-05 | 1 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 101 | 2.875531e-05 | 1 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 87 | 3.027624e-05 | 1 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 87 | 3.027624e-05 | 1 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 28 | 3.173188e-05 | 1 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 91 | 3.654310e-05 | 1 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 108 | 3.915165e-05 | 1 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 134 | 3.945686e-05 | 1 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 134 | 3.945686e-05 | 1 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 29 | 4.203846e-05 | 1 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 45 | 4.389625e-05 | 1 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 104 | 4.538163e-05 | 1 |
| HPA | HPA:0510701 | Soft tissue 2; peripheral nerve[≥Low] | Soft tissue 2; peripheral nerve[≥Low] | 75 | 4.840268e-05 | 1 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 98 | 5.293288e-05 | 1 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 27 | 5.830320e-05 | 1 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 90 | 6.384976e-05 | 1 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 102 | 6.830936e-05 | 1 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 118 | 6.942343e-05 | 1 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 101 | 7.299034e-05 | 1 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 96 | 7.485448e-05 | 1 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 113 | 7.562550e-05 | 1 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 113 | 7.562550e-05 | 1 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 123 | 8.527857e-05 | 1 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 110 | 8.864961e-05 | 1 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 22 | 9.420297e-05 | 1 |
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 97 | 1.075604e-04 | 1 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 98 | 1.099399e-04 | 1 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 124 | 1.252532e-04 | 1 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 124 | 1.252532e-04 | 1 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 120 | 1.296007e-04 | 1 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 120 | 1.296007e-04 | 1 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 99 | 1.318034e-04 | 1 |
| HPA | HPA:0570000 | Testis | Testis | 147 | 1.325648e-04 | 1 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 28 | 1.380101e-04 | 1 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 30 | 1.398589e-04 | 1 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 29 | 1.402584e-04 | 1 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 122 | 1.471634e-04 | 1 |
| HPA | HPA:0390000 | Prostate | Prostate | 122 | 1.471634e-04 | 1 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 121 | 1.867360e-04 | 1 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 123 | 1.911602e-04 | 1 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 28 | 1.989193e-04 | 1 |
| HPA | HPA:0290000 | Liver | Liver | 117 | 1.996160e-04 | 1 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 108 | 2.075088e-04 | 1 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 94 | 2.091848e-04 | 1 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 99 | 2.320824e-04 | 1 |
| HPA | HPA:0270000 | Kidney | Kidney | 139 | 2.370865e-04 | 1 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 110 | 2.458591e-04 | 1 |
| HPA | HPA:0130202 | Colon; endothelial cells[≥Medium] | Colon; endothelial cells[≥Medium] | 81 | 2.646166e-04 | 1 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 62 | 3.331277e-04 | 1 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 117 | 3.661447e-04 | 1 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 24 | 4.000974e-04 | 1 |
| HPA | HPA:0300000 | Lung | Lung | 129 | 4.659252e-04 | 1 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 125 | 4.877175e-04 | 1 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 108 | 5.767748e-04 | 1 |
| HPA | HPA:0620000 | Vagina | Vagina | 112 | 5.907088e-04 | 1 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 112 | 5.907088e-04 | 1 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 78 | 6.093915e-04 | 1 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 132 | 6.112697e-04 | 1 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 132 | 6.112697e-04 | 1 |
| HPA | HPA:0530712 | Spleen; cells in red pulp[≥Medium] | Spleen; cells in red pulp[≥Medium] | 71 | 7.074182e-04 | 1 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 42 | 8.942350e-04 | 1 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 134 | 8.965865e-04 | 1 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 116 | 9.431723e-04 | 1 |
| HPA | HPA:0100211 | Cerebral cortex; neuropil[≥Low] | Cerebral cortex; neuropil[≥Low] | 98 | 9.784169e-04 | 1 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 78 | 9.806741e-04 | 1 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 68 | 1.047584e-03 | 1 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 87 | 1.059931e-03 | 1 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 104 | 1.063313e-03 | 1 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 104 | 1.063313e-03 | 1 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 80 | 1.198937e-03 | 1 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 23 | 1.272396e-03 | 1 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 114 | 1.674695e-03 | 1 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 114 | 1.674695e-03 | 1 |
| HPA | HPA:0130051 | Colon; glandular cells[≥Low] | Colon; glandular cells[≥Low] | 123 | 1.928712e-03 | 1 |
| HPA | HPA:0030051 | Appendix; glandular cells[≥Low] | Appendix; glandular cells[≥Low] | 120 | 1.940159e-03 | 1 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 25 | 2.251117e-03 | 1 |
| HPA | HPA:0130052 | Colon; glandular cells[≥Medium] | Colon; glandular cells[≥Medium] | 110 | 2.474810e-03 | 1 |
| HPA | HPA:0570802 | Testis; sertoli cells[≥Medium] | Testis; sertoli cells[≥Medium] | 48 | 2.555945e-03 | 1 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 44 | 3.151542e-03 | 1 |
| HPA | HPA:0570731 | Testis; Leydig cells[≥Low] | Testis; Leydig cells[≥Low] | 124 | 3.851362e-03 | 1 |
| HPA | HPA:0130242 | Colon; peripheral nerve/ganglion[≥Medium] | Colon; peripheral nerve/ganglion[≥Medium] | 73 | 4.332624e-03 | 1 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 100 | 4.687883e-03 | 1 |
| HPA | HPA:0270362 | Kidney; cells in tubules[≥Medium] | Kidney; cells in tubules[≥Medium] | 107 | 4.809298e-03 | 1 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 55 | 4.815898e-03 | 1 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 87 | 6.578809e-03 | 1 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 22 | 6.623902e-03 | 1 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 23 | 6.889418e-03 | 1 |
| HPA | HPA:0270352 | Kidney; cells in glomeruli[≥Medium] | Kidney; cells in glomeruli[≥Medium] | 67 | 7.149751e-03 | 1 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 47 | 7.193136e-03 | 1 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 102 | 7.947114e-03 | 1 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 21 | 8.568124e-03 | 1 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 100 | 9.250353e-03 | 1 |
| HPA | HPA:0510652 | Soft tissue 2; fibroblasts[≥Medium] | Soft tissue 2; fibroblasts[≥Medium] | 59 | 9.966549e-03 | 1 |
| HPA | HPA:0500702 | Soft tissue 1; peripheral nerve[≥Medium] | Soft tissue 1; peripheral nerve[≥Medium] | 37 | 1.028465e-02 | 1 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 32 | 1.035825e-02 | 1 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 16 | 1.036272e-02 | 1 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 66 | 1.098451e-02 | 1 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 49 | 1.247251e-02 | 1 |
| HPA | HPA:0150051 | Duodenum; glandular cells[≥Low] | Duodenum; glandular cells[≥Low] | 122 | 1.283105e-02 | 1 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 34 | 1.311548e-02 | 1 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 95 | 1.351312e-02 | 1 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 85 | 1.583614e-02 | 1 |
| HPA | HPA:0150052 | Duodenum; glandular cells[≥Medium] | Duodenum; glandular cells[≥Medium] | 109 | 1.635687e-02 | 1 |
| HPA | HPA:0400052 | Rectum; glandular cells[≥Medium] | Rectum; glandular cells[≥Medium] | 109 | 1.635687e-02 | 1 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 48 | 1.754664e-02 | 1 |
| HPA | HPA:0500701 | Soft tissue 1; peripheral nerve[≥Low] | Soft tissue 1; peripheral nerve[≥Low] | 61 | 1.818754e-02 | 1 |
| HPA | HPA:0340451 | Ovary; follicle cells[≥Low] | Ovary; follicle cells[≥Low] | 69 | 1.877365e-02 | 1 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 51 | 1.880996e-02 | 1 |
| HPA | HPA:0091001 | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Low] | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Low] | 15 | 2.112517e-02 | 1 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 57 | 2.370434e-02 | 1 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 18 | 2.422966e-02 | 1 |
| HPA | HPA:0090181 | Cerebellum; cells in granular layer[≥Low] | Cerebellum; cells in granular layer[≥Low] | 87 | 2.460372e-02 | 1 |
| HPA | HPA:0091002 | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium] | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium] | 14 | 2.495609e-02 | 1 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 27 | 2.508005e-02 | 1 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 20 | 2.983226e-02 | 1 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 60 | 3.060894e-02 | 1 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 51 | 3.316666e-02 | 1 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 8 | 3.615423e-02 | 1 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 79 | 3.677944e-02 | 1 |
| HPA | HPA:0400051 | Rectum; glandular cells[≥Low] | Rectum; glandular cells[≥Low] | 120 | 3.812849e-02 | 1 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 79 | 4.075549e-02 | 1 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 61 | 4.132523e-02 | 1 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 14 | 4.287077e-02 | 1 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 33 | 4.396232e-02 | 1 |
| HPA | HPA:0500113 | Soft tissue 1; chondrocytes[High] | Soft tissue 1; chondrocytes[High] | 14 | 4.428987e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2359 | Parkin ubiquitin proteasomal system pathway | Parkin ubiquitin proteasomal system pathway | 17 | 1.684157e-13 | 1 |
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 20 | 1.876849e-13 | 1 |
| WP | WP:WP481 | Insulin signaling | Insulin signaling | 17 | 1.637162e-07 | 1 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 21 | 2.443105e-07 | 1 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 21 | 3.458929e-07 | 1 |
| WP | WP:WP4566 | Translation inhibitors in chronically activated PDGFRA cells | Translation inhibitors in chronically activated PDGFRA cells | 10 | 5.235037e-07 | 1 |
| WP | WP:WP4018 | Clear cell renal cell carcinoma pathways | Clear cell renal cell carcinoma pathways | 12 | 2.316037e-06 | 1 |
| WP | WP:WP3965 | Lipid metabolism pathway | Lipid metabolism pathway | 8 | 2.877460e-06 | 1 |
| WP | WP:WP382 | MAPK signaling | MAPK signaling | 19 | 3.179989e-06 | 1 |
| WP | WP:WP231 | TNF alpha signaling | TNF alpha signaling | 12 | 3.951910e-06 | 1 |
| WP | WP:WP2795 | Cardiac hypertrophic response | Cardiac hypertrophic response | 9 | 3.939486e-05 | 1 |
| WP | WP:WP4290 | Metabolic reprogramming in colon cancer | Metabolic reprogramming in colon cancer | 8 | 6.614152e-05 | 1 |
| WP | WP:WP2380 | Brain derived neurotrophic factor BDNF signaling | Brain derived neurotrophic factor BDNF signaling | 13 | 6.932535e-05 | 1 |
| WP | WP:WP3915 | Angiopoietin like protein 8 regulatory pathway | Angiopoietin like protein 8 regulatory pathway | 12 | 3.188983e-04 | 1 |
| WP | WP:WP195 | IL1 signaling | IL1 signaling | 8 | 4.942226e-04 | 1 |
| WP | WP:WP3879 | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression | 6 | 5.040207e-04 | 1 |
| WP | WP:WP4949 | 16p11 2 proximal deletion syndrome | 16p11 2 proximal deletion syndrome | 9 | 7.781312e-04 | 1 |
| WP | WP:WP183 | Proteasome degradation | Proteasome degradation | 8 | 1.438599e-03 | 1 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 9 | 1.473052e-03 | 1 |
| WP | WP:WP534 | Glycolysis and gluconeogenesis | Glycolysis and gluconeogenesis | 7 | 1.555125e-03 | 1 |
| WP | WP:WP437 | EGF EGFR signaling | EGF EGFR signaling | 12 | 2.093564e-03 | 1 |
| WP | WP:WP2018 | RANKL RANK signaling | RANKL RANK signaling | 7 | 3.197468e-03 | 1 |
| WP | WP:WP4539 | Synaptic signaling associated with autism spectrum disorder | Synaptic signaling associated with autism spectrum disorder | 7 | 3.197468e-03 | 1 |
| WP | WP:WP5531 | AKT signaling and ARTD family members | AKT signaling and ARTD family members | 6 | 3.390958e-03 | 1 |
| WP | WP:WP5441 | Artemisinin inhibition of uveal melanoma | Artemisinin inhibition of uveal melanoma | 3 | 3.623271e-03 | 1 |
| WP | WP:WP5437 | GNAQ pathways in port wine stain | GNAQ pathways in port wine stain | 5 | 3.840081e-03 | 1 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 20 | 4.445939e-03 | 1 |
| WP | WP:WP5215 | Targeted agents in triple negative breast cancer | Targeted agents in triple negative breast cancer | 6 | 6.596321e-03 | 1 |
| WP | WP:WP3932 | Focal adhesion PI3K Akt mTOR signaling | Focal adhesion PI3K Akt mTOR signaling | 16 | 6.775384e-03 | 1 |
| WP | WP:WP4172 | PI3K Akt signaling | PI3K Akt signaling | 17 | 6.813892e-03 | 1 |
| WP | WP:WP2035 | Follicle stimulating hormone FSH signaling | Follicle stimulating hormone FSH signaling | 5 | 7.710285e-03 | 1 |
| WP | WP:WP4223 | Ras signaling | Ras signaling | 12 | 9.139955e-03 | 1 |
| WP | WP:WP4628 | Aerobic glycolysis augmented | Aerobic glycolysis augmented | 4 | 9.350755e-03 | 1 |
| WP | WP:WP1544 | MicroRNAs in cardiomyocyte hypertrophy | MicroRNAs in cardiomyocyte hypertrophy | 9 | 1.018804e-02 | 1 |
| WP | WP:WP5220 | Metabolic reprogramming in pancreatic cancer | Metabolic reprogramming in pancreatic cancer | 6 | 1.187874e-02 | 1 |
| WP | WP:WP4806 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 8 | 1.370992e-02 | 1 |
| WP | WP:WP3873 | RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis | RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis | 4 | 1.740240e-02 | 1 |
| WP | WP:WP5094 | Orexin receptor pathway | Orexin receptor pathway | 8 | 1.913442e-02 | 1 |
| WP | WP:WP673 | ErbB signaling | ErbB signaling | 8 | 2.073781e-02 | 1 |
| WP | WP:WP35 | G protein signaling | G protein signaling | 8 | 2.073781e-02 | 1 |
| WP | WP:WP1403 | AMP activated protein kinase signaling | AMP activated protein kinase signaling | 7 | 2.208979e-02 | 1 |
| WP | WP:WP5355 | Metabolic epileptic disorders | Metabolic epileptic disorders | 8 | 2.427962e-02 | 1 |
| WP | WP:WP5293 | Acute myeloid leukemia | Acute myeloid leukemia | 7 | 2.429234e-02 | 1 |
| WP | WP:WP2038 | Microtubule cytoskeleton regulation | Microtubule cytoskeleton regulation | 6 | 2.563940e-02 | 1 |
| WP | WP:WP1982 | Sterol regulatory element binding proteins SREBP signaling | Sterol regulatory element binding proteins SREBP signaling | 7 | 2.667022e-02 | 1 |
| WP | WP:WP2034 | Leptin signaling | Leptin signaling | 7 | 3.199373e-02 | 1 |
| WP | WP:WP3844 | PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer | PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer | 5 | 3.288328e-02 | 1 |
| WP | WP:WP4549 | Fragile X syndrome | Fragile X syndrome | 9 | 3.312654e-02 | 1 |
| WP | WP:WP5490 | Inhibition of GNAQ regulated signaling in uveal melanoma | Inhibition of GNAQ regulated signaling in uveal melanoma | 5 | 3.824987e-02 | 1 |
| WP | WP:WP5344 | Cardiomyocyte signaling converging on titin | Cardiomyocyte signaling converging on titin | 5 | 3.824987e-02 | 1 |
| WP | WP:WP244 | Alpha 6 beta 4 signaling | Alpha 6 beta 4 signaling | 5 | 3.824987e-02 | 1 |
| WP | WP:WP4540 | Hippo signaling regulation | Hippo signaling regulation | 8 | 4.084406e-02 | 1 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 7 | 4.156527e-02 | 1 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 20 | 4.173838e-02 | 1 |
| WP | WP:WP69 | T cell receptor signaling | T cell receptor signaling | 7 | 4.522603e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 72 | 9.454558e-12 | 1 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 64 | 5.384909e-10 | 1 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 46 | 1.825744e-09 | 1 |
| REAC | REAC:R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | 12 | 1.000815e-08 | 1 |
| REAC | REAC:R-HSA-1280218 | Adaptive Immune System | Adaptive Immune System | 38 | 2.223591e-08 | 1 |
| REAC | REAC:R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | Formation of tubulin folding intermediates by CCT/TriC | 9 | 2.518223e-08 | 1 |
| REAC | REAC:R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 10 | 4.532009e-08 | 1 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 37 | 5.547128e-08 | 1 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 27 | 8.284225e-08 | 1 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 37 | 9.125100e-08 | 1 |
| REAC | REAC:R-HSA-3371556 | Cellular response to heat stress | Cellular response to heat stress | 13 | 1.350972e-07 | 1 |
| REAC | REAC:R-HSA-9646399 | Aggrephagy | Aggrephagy | 10 | 2.208335e-07 | 1 |
| REAC | REAC:R-HSA-390466 | Chaperonin-mediated protein folding | Chaperonin-mediated protein folding | 13 | 2.408546e-07 | 1 |
| REAC | REAC:R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 9 | 2.851021e-07 | 1 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 35 | 5.090094e-07 | 1 |
| REAC | REAC:R-HSA-391251 | Protein folding | Protein folding | 13 | 5.434542e-07 | 1 |
| REAC | REAC:R-HSA-9006925 | Intracellular signaling by second messengers | Intracellular signaling by second messengers | 21 | 5.443099e-07 | 1 |
| REAC | REAC:R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | The role of GTSE1 in G2/M progression after G2 checkpoint | 12 | 5.513023e-07 | 1 |
| REAC | REAC:R-HSA-9663891 | Selective autophagy | Selective autophagy | 12 | 6.405815e-07 | 1 |
| REAC | REAC:R-HSA-390450 | Folding of actin by CCT/TriC | Folding of actin by CCT/TriC | 6 | 7.536722e-07 | 1 |
| REAC | REAC:R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | Regulation of mRNA stability by proteins that bind AU-rich elements | 12 | 1.508955e-06 | 1 |
| REAC | REAC:R-HSA-5358351 | Signaling by Hedgehog | Signaling by Hedgehog | 15 | 1.611856e-06 | 1 |
| REAC | REAC:R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | Prefoldin mediated transfer of substrate to CCT/TriC | 8 | 1.760514e-06 | 1 |
| REAC | REAC:R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | AUF1 (hnRNP D0) binds and destabilizes mRNA | 10 | 1.881742e-06 | 1 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 36 | 2.715774e-06 | 1 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 17 | 3.439144e-06 | 1 |
| REAC | REAC:R-HSA-5610787 | Hedgehog 'off' state | Hedgehog 'off' state | 13 | 3.669198e-06 | 1 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 60 | 5.973647e-06 | 1 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 13 | 6.247785e-06 | 1 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 16 | 9.916711e-06 | 1 |
| REAC | REAC:R-HSA-1257604 | PIP3 activates AKT signaling | PIP3 activates AKT signaling | 18 | 1.012175e-05 | 1 |
| REAC | REAC:R-HSA-3371568 | Attenuation phase | Attenuation phase | 6 | 1.027305e-05 | 1 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 40 | 1.143142e-05 | 1 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 16 | 1.145442e-05 | 1 |
| REAC | REAC:R-HSA-9612973 | Autophagy | Autophagy | 14 | 1.336523e-05 | 1 |
| REAC | REAC:R-HSA-3371571 | HSF1-dependent transactivation | HSF1-dependent transactivation | 7 | 1.474447e-05 | 1 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 27 | 1.715828e-05 | 1 |
| REAC | REAC:R-HSA-8948751 | Regulation of PTEN stability and activity | Regulation of PTEN stability and activity | 10 | 2.220611e-05 | 1 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 26 | 2.750680e-05 | 1 |
| REAC | REAC:R-HSA-1632852 | Macroautophagy | Macroautophagy | 13 | 2.910578e-05 | 1 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 13 | 3.473670e-05 | 1 |
| REAC | REAC:R-HSA-449147 | Signaling by Interleukins | Signaling by Interleukins | 24 | 3.621180e-05 | 1 |
| REAC | REAC:R-HSA-4420097 | VEGFA-VEGFR2 Pathway | VEGFA-VEGFR2 Pathway | 11 | 4.529575e-05 | 1 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 11 | 6.287287e-05 | 1 |
| REAC | REAC:R-HSA-202424 | Downstream TCR signaling | Downstream TCR signaling | 11 | 6.994912e-05 | 1 |
| REAC | REAC:R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | GLI3 is processed to GLI3R by the proteasome | 9 | 7.833301e-05 | 1 |
| REAC | REAC:R-HSA-5610780 | Degradation of GLI1 by the proteasome | Degradation of GLI1 by the proteasome | 9 | 7.833301e-05 | 1 |
| REAC | REAC:R-HSA-5610783 | Degradation of GLI2 by the proteasome | Degradation of GLI2 by the proteasome | 9 | 7.833301e-05 | 1 |
| REAC | REAC:R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | Downstream signaling events of B Cell Receptor (BCR) | 10 | 9.384106e-05 | 1 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 12 | 9.801148e-05 | 1 |
| REAC | REAC:R-HSA-5213460 | RIPK1-mediated regulated necrosis | RIPK1-mediated regulated necrosis | 7 | 1.028975e-04 | 1 |
| REAC | REAC:R-HSA-5675482 | Regulation of necroptotic cell death | Regulation of necroptotic cell death | 7 | 1.028975e-04 | 1 |
| REAC | REAC:R-HSA-194138 | Signaling by VEGF | Signaling by VEGF | 11 | 1.292580e-04 | 1 |
| REAC | REAC:R-HSA-5358346 | Hedgehog ligand biogenesis | Hedgehog ligand biogenesis | 9 | 1.592655e-04 | 1 |
| REAC | REAC:R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | Signaling by Receptor Tyrosine Kinases | 24 | 1.612474e-04 | 1 |
| REAC | REAC:R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | Fc epsilon receptor (FCERI) signaling | 14 | 1.640979e-04 | 1 |
| REAC | REAC:R-HSA-3371511 | HSF1 activation | HSF1 activation | 5 | 1.962020e-04 | 1 |
| REAC | REAC:R-HSA-1169091 | Activation of NF-kappaB in B cells | Activation of NF-kappaB in B cells | 9 | 2.078442e-04 | 1 |
| REAC | REAC:R-HSA-389357 | CD28 dependent PI3K/Akt signaling | CD28 dependent PI3K/Akt signaling | 6 | 2.319345e-04 | 1 |
| REAC | REAC:R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 7 | 2.506730e-04 | 1 |
| REAC | REAC:R-HSA-6804757 | Regulation of TP53 Degradation | Regulation of TP53 Degradation | 7 | 3.074295e-04 | 1 |
| REAC | REAC:R-HSA-9013418 | RHOBTB2 GTPase cycle | RHOBTB2 GTPase cycle | 6 | 3.100626e-04 | 1 |
| REAC | REAC:R-HSA-9604323 | Negative regulation of NOTCH4 signaling | Negative regulation of NOTCH4 signaling | 8 | 3.695971e-04 | 1 |
| REAC | REAC:R-HSA-6806003 | Regulation of TP53 Expression and Degradation | Regulation of TP53 Expression and Degradation | 7 | 3.745934e-04 | 1 |
| REAC | REAC:R-HSA-9009391 | Extra-nuclear estrogen signaling | Extra-nuclear estrogen signaling | 9 | 3.890235e-04 | 1 |
| REAC | REAC:R-HSA-3858494 | Beta-catenin independent WNT signaling | Beta-catenin independent WNT signaling | 12 | 4.616882e-04 | 1 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 64 | 5.078711e-04 | 1 |
| REAC | REAC:R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | G beta:gamma signalling through PI3Kgamma | 6 | 5.311137e-04 | 1 |
| REAC | REAC:R-HSA-202403 | TCR signaling | TCR signaling | 11 | 5.515692e-04 | 1 |
| REAC | REAC:R-HSA-5362768 | Hh mutants are degraded by ERAD | Hh mutants are degraded by ERAD | 8 | 5.709982e-04 | 1 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 20 | 7.253398e-04 | 1 |
| REAC | REAC:R-HSA-5387390 | Hh mutants abrogate ligand secretion | Hh mutants abrogate ligand secretion | 8 | 8.592436e-04 | 1 |
| REAC | REAC:R-HSA-5218920 | VEGFR2 mediated vascular permeability | VEGFR2 mediated vascular permeability | 6 | 8.667468e-04 | 1 |
| REAC | REAC:R-HSA-8863795 | Downregulation of ERBB2 signaling | Downregulation of ERBB2 signaling | 6 | 8.667468e-04 | 1 |
| REAC | REAC:R-HSA-9013694 | Signaling by NOTCH4 | Signaling by NOTCH4 | 9 | 1.067373e-03 | 1 |
| REAC | REAC:R-HSA-5678895 | Defective CFTR causes cystic fibrosis | Defective CFTR causes cystic fibrosis | 8 | 1.113515e-03 | 1 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 9 | 1.184302e-03 | 1 |
| REAC | REAC:R-HSA-2467813 | Separation of Sister Chromatids | Separation of Sister Chromatids | 13 | 1.448172e-03 | 1 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 9 | 1.451572e-03 | 1 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 23 | 1.736810e-03 | 1 |
| REAC | REAC:R-HSA-1227986 | Signaling by ERBB2 | Signaling by ERBB2 | 7 | 1.746248e-03 | 1 |
| REAC | REAC:R-HSA-9824439 | Bacterial Infection Pathways | Bacterial Infection Pathways | 8 | 2.043014e-03 | 1 |
| REAC | REAC:R-HSA-389356 | Co-stimulation by CD28 | Co-stimulation by CD28 | 6 | 2.055299e-03 | 1 |
| REAC | REAC:R-HSA-6807070 | PTEN Regulation | PTEN Regulation | 11 | 2.186946e-03 | 1 |
| REAC | REAC:R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | Regulation of HSF1-mediated heat shock response | 8 | 2.291851e-03 | 1 |
| REAC | REAC:R-HSA-388841 | Regulation of T cell activation by CD28 family | Regulation of T cell activation by CD28 family | 8 | 2.291851e-03 | 1 |
| REAC | REAC:R-HSA-9020702 | Interleukin-1 signaling | Interleukin-1 signaling | 10 | 2.353100e-03 | 1 |
| REAC | REAC:R-HSA-5687128 | MAPK6/MAPK4 signaling | MAPK6/MAPK4 signaling | 9 | 2.356771e-03 | 1 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 14 | 2.413131e-03 | 1 |
| REAC | REAC:R-HSA-397795 | G-protein beta:gamma signalling | G-protein beta:gamma signalling | 6 | 2.499571e-03 | 1 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 14 | 2.538490e-03 | 1 |
| REAC | REAC:R-HSA-1236974 | ER-Phagosome pathway | ER-Phagosome pathway | 9 | 2.586623e-03 | 1 |
| REAC | REAC:R-HSA-5617833 | Cilium Assembly | Cilium Assembly | 13 | 2.861960e-03 | 1 |
| REAC | REAC:R-HSA-163359 | Glucagon signaling in metabolic regulation | Glucagon signaling in metabolic regulation | 6 | 3.018773e-03 | 1 |
| REAC | REAC:R-HSA-4086400 | PCP/CE pathway | PCP/CE pathway | 9 | 3.104473e-03 | 1 |
| REAC | REAC:R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | Regulation of activated PAK-2p34 by proteasome mediated degradation | 7 | 3.104687e-03 | 1 |
| REAC | REAC:R-HSA-8939902 | Regulation of RUNX2 expression and activity | Regulation of RUNX2 expression and activity | 8 | 3.560092e-03 | 1 |
| REAC | REAC:R-HSA-446203 | Asparagine N-linked glycosylation | Asparagine N-linked glycosylation | 16 | 3.804554e-03 | 1 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 9 | 4.046733e-03 | 1 |
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 9 | 4.046733e-03 | 1 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 12 | 4.055026e-03 | 1 |
| REAC | REAC:R-HSA-180534 | Vpu mediated degradation of CD4 | Vpu mediated degradation of CD4 | 7 | 4.058959e-03 | 1 |
| REAC | REAC:R-HSA-69610 | p53-Independent DNA Damage Response | p53-Independent DNA Damage Response | 7 | 4.058959e-03 | 1 |
| REAC | REAC:R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 7 | 4.058959e-03 | 1 |
| REAC | REAC:R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint | p53-Independent G1/S DNA damage checkpoint | 7 | 4.058959e-03 | 1 |
| REAC | REAC:R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | Ubiquitin-dependent degradation of Cyclin D | 7 | 4.058959e-03 | 1 |
| REAC | REAC:R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 7 | 4.058959e-03 | 1 |
| REAC | REAC:R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | Autodegradation of the E3 ubiquitin ligase COP1 | 7 | 4.058959e-03 | 1 |
| REAC | REAC:R-HSA-9706574 | RHOBTB GTPase Cycle | RHOBTB GTPase Cycle | 6 | 4.319704e-03 | 1 |
| REAC | REAC:R-HSA-169911 | Regulation of Apoptosis | Regulation of Apoptosis | 7 | 4.620384e-03 | 1 |
| REAC | REAC:R-HSA-180585 | Vif-mediated degradation of APOBEC3G | Vif-mediated degradation of APOBEC3G | 7 | 4.620384e-03 | 1 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 13 | 4.858938e-03 | 1 |
| REAC | REAC:R-HSA-446652 | Interleukin-1 family signaling | Interleukin-1 family signaling | 11 | 5.195429e-03 | 1 |
| REAC | REAC:R-HSA-9613829 | Chaperone Mediated Autophagy | Chaperone Mediated Autophagy | 5 | 5.803379e-03 | 1 |
| REAC | REAC:R-HSA-4641257 | Degradation of AXIN | Degradation of AXIN | 7 | 5.937290e-03 | 1 |
| REAC | REAC:R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | SCF-beta-TrCP mediated degradation of Emi1 | 7 | 5.937290e-03 | 1 |
| REAC | REAC:R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 7 | 5.937290e-03 | 1 |
| REAC | REAC:R-HSA-8941858 | Regulation of RUNX3 expression and activity | Regulation of RUNX3 expression and activity | 7 | 5.937290e-03 | 1 |
| REAC | REAC:R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | TNFR2 non-canonical NF-kB pathway | 9 | 6.160821e-03 | 1 |
| REAC | REAC:R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | Association of TriC/CCT with target proteins during biosynthesis | 6 | 7.088679e-03 | 1 |
| REAC | REAC:R-HSA-5619084 | ABC transporter disorders | ABC transporter disorders | 8 | 7.203021e-03 | 1 |
| REAC | REAC:R-HSA-69541 | Stabilization of p53 | Stabilization of p53 | 7 | 7.550589e-03 | 1 |
| REAC | REAC:R-HSA-4641258 | Degradation of DVL | Degradation of DVL | 7 | 7.550589e-03 | 1 |
| REAC | REAC:R-HSA-5218859 | Regulated Necrosis | Regulated Necrosis | 7 | 8.483746e-03 | 1 |
| REAC | REAC:R-HSA-1236975 | Antigen processing-Cross presentation | Antigen processing-Cross presentation | 9 | 9.152543e-03 | 1 |
| REAC | REAC:R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | NIK-->noncanonical NF-kB signaling | 7 | 9.510121e-03 | 1 |
| REAC | REAC:R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 8 | 1.042755e-02 | 1 |
| REAC | REAC:R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | Dectin-1 mediated noncanonical NF-kB signaling | 7 | 1.063682e-02 | 1 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 7 | 1.063682e-02 | 1 |
| REAC | REAC:R-HSA-163685 | Integration of energy metabolism | Integration of energy metabolism | 9 | 1.065522e-02 | 1 |
| REAC | REAC:R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | Signaling by the B Cell Receptor (BCR) | 11 | 1.068019e-02 | 1 |
| REAC | REAC:R-HSA-5339562 | Uptake and actions of bacterial toxins | Uptake and actions of bacterial toxins | 5 | 1.130543e-02 | 1 |
| REAC | REAC:R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | Constitutive Signaling by AKT1 E17K in Cancer | 5 | 1.130543e-02 | 1 |
| REAC | REAC:R-HSA-2871837 | FCERI mediated NF-kB activation | FCERI mediated NF-kB activation | 10 | 1.212653e-02 | 1 |
| REAC | REAC:R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 6 | 1.284249e-02 | 1 |
| REAC | REAC:R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | ADORA2B mediated anti-inflammatory cytokines production | 6 | 1.284249e-02 | 1 |
| REAC | REAC:R-HSA-901042 | Calnexin/calreticulin cycle | Calnexin/calreticulin cycle | 5 | 1.383475e-02 | 1 |
| REAC | REAC:R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | Vasopressin regulates renal water homeostasis via Aquaporins | 6 | 1.474826e-02 | 1 |
| REAC | REAC:R-HSA-983169 | Class I MHC mediated antigen processing & presentation | Class I MHC mediated antigen processing & presentation | 17 | 1.557252e-02 | 1 |
| REAC | REAC:R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | Autodegradation of Cdh1 by Cdh1:APC/C | 7 | 1.630212e-02 | 1 |
| REAC | REAC:R-HSA-4608870 | Asymmetric localization of PCP proteins | Asymmetric localization of PCP proteins | 7 | 1.630212e-02 | 1 |
| REAC | REAC:R-HSA-9634597 | GPER1 signaling | GPER1 signaling | 6 | 1.687469e-02 | 1 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 24 | 1.799787e-02 | 1 |
| REAC | REAC:R-HSA-5683057 | MAPK family signaling cascades | MAPK family signaling cascades | 15 | 1.895191e-02 | 1 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 7 | 1.994943e-02 | 1 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 7 | 1.994943e-02 | 1 |
| REAC | REAC:R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 7 | 1.994943e-02 | 1 |
| REAC | REAC:R-HSA-5357905 | Regulation of TNFR1 signaling | Regulation of TNFR1 signaling | 6 | 2.186435e-02 | 1 |
| REAC | REAC:R-HSA-5658442 | Regulation of RAS by GAPs | Regulation of RAS by GAPs | 7 | 2.200948e-02 | 1 |
| REAC | REAC:R-HSA-2219528 | PI3K/AKT Signaling in Cancer | PI3K/AKT Signaling in Cancer | 8 | 2.227943e-02 | 1 |
| REAC | REAC:R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | Antiviral mechanism by IFN-stimulated genes | 10 | 2.365044e-02 | 1 |
| REAC | REAC:R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | APC/C:Cdc20 mediated degradation of Securin | 7 | 2.424071e-02 | 1 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 7 | 2.424071e-02 | 1 |
| REAC | REAC:R-HSA-5336415 | Uptake and function of diphtheria toxin | Uptake and function of diphtheria toxin | 3 | 2.606790e-02 | 1 |
| REAC | REAC:R-HSA-437239 | Recycling pathway of L1 | Recycling pathway of L1 | 6 | 2.797059e-02 | 1 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 8 | 2.813355e-02 | 1 |
| REAC | REAC:R-HSA-8939211 | ESR-mediated signaling | ESR-mediated signaling | 12 | 2.962450e-02 | 1 |
| REAC | REAC:R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | Cross-presentation of soluble exogenous antigens (endosomes) | 6 | 3.149637e-02 | 1 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 7 | 3.207103e-02 | 1 |
| REAC | REAC:R-HSA-1852241 | Organelle biogenesis and maintenance | Organelle biogenesis and maintenance | 14 | 3.668771e-02 | 1 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 14 | 3.805889e-02 | 1 |
| REAC | REAC:R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 7 | 3.835579e-02 | 1 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 7 | 3.835579e-02 | 1 |
| REAC | REAC:R-HSA-5689880 | Ub-specific processing proteases | Ub-specific processing proteases | 12 | 3.859439e-02 | 1 |
| REAC | REAC:R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | Signaling by Ligand-Responsive EGFR Variants in Cancer | 4 | 3.921192e-02 | 1 |
| REAC | REAC:R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4 | 3.921192e-02 | 1 |
| REAC | REAC:R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | Regulation of ornithine decarboxylase (ODC) | 6 | 3.960965e-02 | 1 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 7 | 4.185516e-02 | 1 |
| REAC | REAC:R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 7 | 4.185516e-02 | 1 |
| REAC | REAC:R-HSA-76002 | Platelet activation, signaling and aggregation | Platelet activation, signaling and aggregation | 13 | 4.342642e-02 | 1 |
| REAC | REAC:R-HSA-445717 | Aquaporin-mediated transport | Aquaporin-mediated transport | 6 | 4.424669e-02 | 1 |
| REAC | REAC:R-HSA-163765 | ChREBP activates metabolic gene expression | ChREBP activates metabolic gene expression | 3 | 4.513458e-02 | 1 |
| REAC | REAC:R-HSA-9833482 | PKR-mediated signaling | PKR-mediated signaling | 7 | 4.561035e-02 | 1 |
| REAC | REAC:R-HSA-1234174 | Cellular response to hypoxia | Cellular response to hypoxia | 7 | 4.561035e-02 | 1 |
| REAC | REAC:R-HSA-438064 | Post NMDA receptor activation events | Post NMDA receptor activation events | 7 | 4.561035e-02 | 1 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 14 | 4.726290e-02 | 1 |
| REAC | REAC:R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | COPI-independent Golgi-to-ER retrograde traffic | 6 | 4.930537e-02 | 1 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 7 | 4.963530e-02 | 1 |
| REAC | REAC:R-HSA-9758274 | Regulation of NF-kappa B signaling | Regulation of NF-kappa B signaling | 4 | 4.985002e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 40 | 1.341054e-11 | 1 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 45 | 4.682428e-10 | 1 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 48 | 6.587268e-10 | 1 |
| MIRNA | MIRNA:hsa-mir-34a-5p | hsa-mir-34a-5p | hsa-mir-34a-5p | 24 | 4.808025e-06 | 1 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 19 | 2.927576e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 42 | 9.656871e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-324-3p | hsa-mir-324-3p | hsa-mir-324-3p | 39 | 2.093491e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-484 | hsa-mir-484 | hsa-mir-484 | 45 | 3.605098e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-331-3p | hsa-mir-331-3p | hsa-mir-331-3p | 33 | 5.499409e-04 | 1 |
| MIRNA | MIRNA:hsa-let-7b-5p | hsa-let-7b-5p | hsa-let-7b-5p | 31 | 1.069213e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-455-3p | hsa-mir-455-3p | hsa-mir-455-3p | 34 | 1.231490e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 24 | 3.660054e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-1229-3p | hsa-mir-1229-3p | hsa-mir-1229-3p | 11 | 4.731700e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-149-5p | hsa-mir-149-5p | hsa-mir-149-5p | 15 | 9.466184e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-127-5p | hsa-mir-127-5p | hsa-mir-127-5p | 23 | 1.228204e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-513a-3p | hsa-mir-513a-3p | hsa-mir-513a-3p | 38 | 1.816893e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-23b-3p | hsa-mir-23b-3p | hsa-mir-23b-3p | 13 | 2.398691e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3692 | hsa-mir-3692 | hsa-mir-3692 | 30 | 3.004441e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-1180-3p | hsa-mir-1180-3p | hsa-mir-1180-3p | 6 | 3.097708e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 18 | 3.243478e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-324-5p | hsa-mir-324-5p | hsa-mir-324-5p | 22 | 3.425502e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-548p | hsa-mir-548p | hsa-mir-548p | 36 | 3.746545e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-222-3p | hsa-mir-222-3p | hsa-mir-222-3p | 14 | 4.378194e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-889 | hsa-mir-889 | hsa-mir-889 | 26 | 4.581701e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 18 | 7.814699e-09 | 1 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | Lipid and atherosclerosis | 19 | 5.890807e-08 | 1 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 27 | 2.571725e-07 | 1 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 19 | 7.490575e-07 | 1 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 23 | 1.644477e-06 | 1 |
| KEGG | KEGG:04910 | Insulin signaling pathway | Insulin signaling pathway | 14 | 2.064373e-06 | 1 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 19 | 2.075090e-06 | 1 |
| KEGG | KEGG:04612 | Antigen processing and presentation | Antigen processing and presentation | 10 | 8.373755e-06 | 1 |
| KEGG | KEGG:04010 | MAPK signaling pathway | MAPK signaling pathway | 19 | 1.583770e-05 | 1 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | Human immunodeficiency virus 1 infection | 15 | 7.402639e-05 | 1 |
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 11 | 7.406565e-05 | 1 |
| KEGG | KEGG:05020 | Prion disease | Prion disease | 17 | 8.173829e-05 | 1 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 15 | 1.583353e-04 | 1 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | Spinocerebellar ataxia | 12 | 1.602197e-04 | 1 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | Longevity regulating pathway - multiple species | 8 | 3.717097e-04 | 1 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | HIF-1 signaling pathway | 10 | 6.201938e-04 | 1 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | Estrogen signaling pathway | 11 | 7.226700e-04 | 1 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | PD-L1 expression and PD-1 checkpoint pathway in cancer | 9 | 8.206812e-04 | 1 |
| KEGG | KEGG:04140 | Autophagy - animal | Autophagy - animal | 12 | 8.270047e-04 | 1 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 13 | 1.052991e-03 | 1 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | Neurotrophin signaling pathway | 10 | 1.259406e-03 | 1 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 9 | 1.661590e-03 | 1 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | Relaxin signaling pathway | 10 | 2.749953e-03 | 1 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 17 | 3.127863e-03 | 1 |
| KEGG | KEGG:05145 | Toxoplasmosis | Toxoplasmosis | 9 | 3.937483e-03 | 1 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 17 | 4.001831e-03 | 1 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 12 | 4.190514e-03 | 1 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | Fluid shear stress and atherosclerosis | 10 | 4.911609e-03 | 1 |
| KEGG | KEGG:04725 | Cholinergic synapse | Cholinergic synapse | 9 | 5.629148e-03 | 1 |
| KEGG | KEGG:04540 | Gap junction | Gap junction | 8 | 5.707715e-03 | 1 |
| KEGG | KEGG:03050 | Proteasome | Proteasome | 6 | 6.468532e-03 | 1 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 15 | 6.712938e-03 | 1 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | Acute myeloid leukemia | 7 | 6.844346e-03 | 1 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | Central carbon metabolism in cancer | 7 | 9.076770e-03 | 1 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 7 | 1.087017e-02 | 1 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 20 | 1.561201e-02 | 1 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | Chemokine signaling pathway | 11 | 1.583275e-02 | 1 |
| KEGG | KEGG:04728 | Dopaminergic synapse | Dopaminergic synapse | 9 | 1.761508e-02 | 1 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 7 | 1.954631e-02 | 1 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 9 | 2.210237e-02 | 1 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | B cell receptor signaling pathway | 7 | 2.285112e-02 | 1 |
| KEGG | KEGG:04014 | Ras signaling pathway | Ras signaling pathway | 12 | 2.589961e-02 | 1 |
| KEGG | KEGG:04371 | Apelin signaling pathway | Apelin signaling pathway | 9 | 2.605862e-02 | 1 |
| KEGG | KEGG:04012 | ErbB signaling pathway | ErbB signaling pathway | 7 | 2.863867e-02 | 1 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 11 | 3.064376e-02 | 1 |
| KEGG | KEGG:04668 | TNF signaling pathway | TNF signaling pathway | 8 | 3.283755e-02 | 1 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | Chemical carcinogenesis - receptor activation | 11 | 3.920082e-02 | 1 |
| KEGG | KEGG:04211 | Longevity regulating pathway | Longevity regulating pathway | 7 | 4.085405e-02 | 1 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | T cell receptor signaling pathway | 8 | 4.655761e-02 | 1 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | Growth hormone synthesis, secretion and action | 8 | 4.924053e-02 | 1 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 8 | 4.924053e-02 | 1 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 7 | 4.997940e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:126 | CCT complex (chaperonin containing TCP1 complex) | CCT complex (chaperonin containing TCP1 complex) | 6 | 8.519520e-07 | 1 |
| CORUM | CORUM:2112 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex | 4 | 6.012253e-05 | 1 |
| CORUM | CORUM:5212 | Kinase maturation complex 2 | Kinase maturation complex 2 | 5 | 7.337571e-05 | 1 |
| CORUM | CORUM:5269 | TNF-alpha/NF-kappa B signaling complex 8 | TNF-alpha/NF-kappa B signaling complex 8 | 4 | 8.688458e-04 | 1 |
| CORUM | CORUM:5849 | HSP90-CDC37-LRRK2 complex | HSP90-CDC37-LRRK2 complex | 3 | 2.572331e-03 | 1 |
| CORUM | CORUM:5980 | LRRK2-CHIP-HSP90 complex | LRRK2-CHIP-HSP90 complex | 3 | 2.572331e-03 | 1 |
| CORUM | CORUM:5268 | TNF-alpha/NF-kappa B signaling complex 7 | TNF-alpha/NF-kappa B signaling complex 7 | 4 | 3.906442e-03 | 1 |
| CORUM | CORUM:5199 | Kinase maturation complex 1 | Kinase maturation complex 1 | 5 | 4.910777e-03 | 1 |
| CORUM | CORUM:6247 | BBS-chaperonin complex | BBS-chaperonin complex | 4 | 1.129152e-02 | 1 |
| CORUM | CORUM:5286 | TNF-alpha/NF-kappa B signaling complex 10 | TNF-alpha/NF-kappa B signaling complex 10 | 4 | 1.129152e-02 | 1 |
| CORUM | CORUM:32 | PA700 complex | PA700 complex | 5 | 1.614836e-02 | 1 |
| CORUM | CORUM:5234 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex | 3 | 2.482980e-02 | 1 |
| CORUM | CORUM:5285 | TNF-alpha/NF-kappa B signaling complex 9 | TNF-alpha/NF-kappa B signaling complex 9 | 3 | 2.482980e-02 | 1 |
| CORUM | CORUM:5266 | TNF-alpha/NF-kappa B signaling complex 6 | TNF-alpha/NF-kappa B signaling complex 6 | 4 | 3.636207e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M07206 | Factor: E2F-1; motif: NGGGCGGGARV | Factor: E2F-1; motif: NGGGCGGGARV | 165 | 0.000013 | 1 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 161 | 0.000013 | 1 |
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 162 | 0.000013 | 1 |
| TF | TF:M01660 | Factor: GABP-alpha; motif: CTTCCK | Factor: GABP-alpha; motif: CTTCCK | 139 | 0.000015 | 1 |
| TF | TF:M03567 | Factor: Sp2; motif: NYSGCCCCGCCCCCY | Factor: Sp2; motif: NYSGCCCCGCCCCCY | 109 | 0.000029 | 1 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 143 | 0.000039 | 1 |
| TF | TF:M13135 | Factor: SP4; motif: GGCCCCGCCCCCN | Factor: SP4; motif: GGCCCCGCCCCCN | 87 | 0.000050 | 1 |
| TF | TF:M12173 | Factor: GKLF; motif: NNCCMCRCCCN | Factor: GKLF; motif: NNCCMCRCCCN | 129 | 0.000051 | 1 |
| TF | TF:M12666 | Factor: SP1; motif: GGCCCCGCCCCCN | Factor: SP1; motif: GGCCCCGCCCCCN | 117 | 0.000068 | 1 |
| TF | TF:M00196 | Factor: Sp1; motif: NGGGGGCGGGGYN | Factor: Sp1; motif: NGGGGGCGGGGYN | 131 | 0.000069 | 1 |
| TF | TF:M12151 | Factor: Sp1; motif: NWRGCCMCGCCCMCN | Factor: Sp1; motif: NWRGCCMCGCCCMCN | 99 | 0.000096 | 1 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 132 | 0.000097 | 1 |
| TF | TF:M11601_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 137 | 0.000139 | 1 |
| TF | TF:M09950_1 | Factor: HSF1; motif: NRGAANNTTCYRGAA; match class: 1 | Factor: HSF1; motif: NRGAANNTTCYRGAA; match class: 1 | 14 | 0.000188 | 1 |
| TF | TF:M11656_1 | Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1 | Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1 | 13 | 0.000273 | 1 |
| TF | TF:M03807 | Factor: SP2; motif: GNNGGGGGCGGGGSN | Factor: SP2; motif: GNNGGGGGCGGGGSN | 113 | 0.000301 | 1 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 165 | 0.000364 | 1 |
| TF | TF:M01783 | Factor: SP2; motif: GGGCGGGAC | Factor: SP2; motif: GGGCGGGAC | 119 | 0.000388 | 1 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 169 | 0.000465 | 1 |
| TF | TF:M00931 | Factor: Sp1; motif: GGGGCGGGGC | Factor: Sp1; motif: GGGGCGGGGC | 129 | 0.000515 | 1 |
| TF | TF:M07395 | Factor: Sp1; motif: NGGGGCGGGGN | Factor: Sp1; motif: NGGGGCGGGGN | 132 | 0.000545 | 1 |
| TF | TF:M02070 | Factor: TEL1; motif: CNCGGAANNN | Factor: TEL1; motif: CNCGGAANNN | 133 | 0.000549 | 1 |
| TF | TF:M08523 | Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN | Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN | 144 | 0.000577 | 1 |
| TF | TF:M00932 | Factor: Sp1; motif: NNGGGGCGGGGNN | Factor: Sp1; motif: NNGGGGCGGGGNN | 130 | 0.000604 | 1 |
| TF | TF:M08309 | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN | 148 | 0.000623 | 1 |
| TF | TF:M09765 | Factor: SP1; motif: NRGKGGGCGGGGCN | Factor: SP1; motif: NRGKGGGCGGGGCN | 103 | 0.000635 | 1 |
| TF | TF:M02052 | Factor: EHF; motif: CSCGGAARTN | Factor: EHF; motif: CSCGGAARTN | 126 | 0.000753 | 1 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 171 | 0.000824 | 1 |
| TF | TF:M11529_1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | 161 | 0.000874 | 1 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 129 | 0.001291 | 1 |
| TF | TF:M05361 | Factor: Sp6; motif: WGGGCGG | Factor: Sp6; motif: WGGGCGG | 112 | 0.001414 | 1 |
| TF | TF:M05444 | Factor: CPBP; motif: NGGGCGG | Factor: CPBP; motif: NGGGCGG | 112 | 0.001414 | 1 |
| TF | TF:M05332 | Factor: Sp2; motif: WGGGCGG | Factor: Sp2; motif: WGGGCGG | 112 | 0.001414 | 1 |
| TF | TF:M07063 | Factor: Sp1; motif: GGGGCGGGGC | Factor: Sp1; motif: GGGGCGGGGC | 90 | 0.001491 | 1 |
| TF | TF:M00736 | Factor: E2F-1:DP-1; motif: TTTCSCGC | Factor: E2F-1:DP-1; motif: TTTCSCGC | 128 | 0.001575 | 1 |
| TF | TF:M11654_1 | Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1 | Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1 | 9 | 0.001911 | 1 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 165 | 0.001936 | 1 |
| TF | TF:M02090 | Factor: E2F-4; motif: GCGGGAAANA | Factor: E2F-4; motif: GCGGGAAANA | 141 | 0.002133 | 1 |
| TF | TF:M10072 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | 129 | 0.002528 | 1 |
| TF | TF:M07409 | Factor: BTEB2; motif: GCCCCRCCCH | Factor: BTEB2; motif: GCCCCRCCCH | 78 | 0.003000 | 1 |
| TF | TF:M02065_1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | 96 | 0.003060 | 1 |
| TF | TF:M01588 | Factor: GKLF; motif: GCCMCRCCCNNN | Factor: GKLF; motif: GCCMCRCCCNNN | 114 | 0.003798 | 1 |
| TF | TF:M02089 | Factor: E2F-3; motif: GGCGGGN | Factor: E2F-3; motif: GGCGGGN | 150 | 0.003804 | 1 |
| TF | TF:M11529 | Factor: E2F-2; motif: GCGCGCGCNCS | Factor: E2F-2; motif: GCGCGCGCNCS | 171 | 0.003811 | 1 |
| TF | TF:M04869_1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | 126 | 0.003925 | 1 |
| TF | TF:M11655_1 | Factor: HSF1; motif: NGAANGTTCKRGAAN; match class: 1 | Factor: HSF1; motif: NGAANGTTCKRGAAN; match class: 1 | 8 | 0.003975 | 1 |
| TF | TF:M11434 | Factor: Elk-1; motif: NRSCGGAAGNN | Factor: Elk-1; motif: NRSCGGAAGNN | 107 | 0.005277 | 1 |
| TF | TF:M04869 | Factor: Egr-1; motif: GCGCATGCG | Factor: Egr-1; motif: GCGCATGCG | 134 | 0.005291 | 1 |
| TF | TF:M00196_1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | 85 | 0.005489 | 1 |
| TF | TF:M09892 | Factor: E2F-1; motif: NNNNGGCGGGAARN | Factor: E2F-1; motif: NNNNGGCGGGAARN | 152 | 0.006928 | 1 |
| TF | TF:M02053 | Factor: ELF1; motif: NCCGGAARTN | Factor: ELF1; motif: NCCGGAARTN | 85 | 0.006975 | 1 |
| TF | TF:M09970 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN | 102 | 0.007938 | 1 |
| TF | TF:M02064 | Factor: c-ets-2; motif: ACCGGAWRTN | Factor: c-ets-2; motif: ACCGGAWRTN | 130 | 0.009376 | 1 |
| TF | TF:M04826 | Factor: p300; motif: ACNTCCG | Factor: p300; motif: ACNTCCG | 178 | 0.009650 | 1 |
| TF | TF:M07084 | Factor: E2F-4; motif: NGGCGGGAARN | Factor: E2F-4; motif: NGGCGGGAARN | 130 | 0.009733 | 1 |
| TF | TF:M08309_1 | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN; match class: 1 | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN; match class: 1 | 95 | 0.010045 | 1 |
| TF | TF:M00931_1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | 84 | 0.010192 | 1 |
| TF | TF:M07206_1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | 130 | 0.010750 | 1 |
| TF | TF:M04010 | Factor: HSF4; motif: TTCTAGAANNTTC | Factor: HSF4; motif: TTCTAGAANNTTC | 10 | 0.010996 | 1 |
| TF | TF:M01023_1 | Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 1 | Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 1 | 12 | 0.011290 | 1 |
| TF | TF:M12597 | Factor: E2F1; motif: GSGCGGGAAN | Factor: E2F1; motif: GSGCGGGAAN | 155 | 0.011525 | 1 |
| TF | TF:M10530 | Factor: sp4; motif: NNNGCYCCGCCCCCY | Factor: sp4; motif: NNNGCYCCGCCCCCY | 106 | 0.011744 | 1 |
| TF | TF:M08205 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | 158 | 0.011783 | 1 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 145 | 0.012175 | 1 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 161 | 0.012327 | 1 |
| TF | TF:M08313_1 | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 | 119 | 0.012380 | 1 |
| TF | TF:M00932_1 | Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 | Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 | 85 | 0.014069 | 1 |
| TF | TF:M00803_1 | Factor: E2F; motif: GGCGSG; match class: 1 | Factor: E2F; motif: GGCGSG; match class: 1 | 124 | 0.014553 | 1 |
| TF | TF:M09826 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | 136 | 0.014606 | 1 |
| TF | TF:M07395_1 | Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 | Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 | 88 | 0.015033 | 1 |
| TF | TF:M01240 | Factor: BEN; motif: CAGCGRNV | Factor: BEN; motif: CAGCGRNV | 171 | 0.016130 | 1 |
| TF | TF:M13031_1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | 72 | 0.016942 | 1 |
| TF | TF:M05361_1 | Factor: Sp6; motif: WGGGCGG; match class: 1 | Factor: Sp6; motif: WGGGCGG; match class: 1 | 55 | 0.017069 | 1 |
| TF | TF:M05332_1 | Factor: Sp2; motif: WGGGCGG; match class: 1 | Factor: Sp2; motif: WGGGCGG; match class: 1 | 55 | 0.017069 | 1 |
| TF | TF:M05444_1 | Factor: CPBP; motif: NGGGCGG; match class: 1 | Factor: CPBP; motif: NGGGCGG; match class: 1 | 55 | 0.017069 | 1 |
| TF | TF:M11659_1 | Factor: HSF4; motif: NGAANRTTCTAGAAN; match class: 1 | Factor: HSF4; motif: NGAANRTTCTAGAAN; match class: 1 | 4 | 0.017100 | 1 |
| TF | TF:M04008_1 | Factor: HSF1; motif: TTCTAGAAYNTTC; match class: 1 | Factor: HSF1; motif: TTCTAGAAYNTTC; match class: 1 | 4 | 0.017100 | 1 |
| TF | TF:M00333 | Factor: ZF5; motif: NRNGNGCGCGCWN | Factor: ZF5; motif: NRNGNGCGCGCWN | 162 | 0.017444 | 1 |
| TF | TF:M07615 | Factor: Sp3; motif: GGGGCGGGGSNN | Factor: Sp3; motif: GGGGCGGGGSNN | 92 | 0.018474 | 1 |
| TF | TF:M11603_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 148 | 0.018489 | 1 |
| TF | TF:M09636_1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | 155 | 0.020215 | 1 |
| TF | TF:M08377 | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN | 132 | 0.020407 | 1 |
| TF | TF:M08225_1 | Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 | Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 | 103 | 0.021527 | 1 |
| TF | TF:M11657_1 | Factor: HSF1; motif: NGAANRTTCKAGAAN; match class: 1 | Factor: HSF1; motif: NGAANRTTCKAGAAN; match class: 1 | 4 | 0.023155 | 1 |
| TF | TF:M07039 | Factor: ETF; motif: CCCCGCCCCYN | Factor: ETF; motif: CCCCGCCCCYN | 170 | 0.025122 | 1 |
| TF | TF:M12668_1 | Factor: SP2; motif: NNRRCCAATSRGNRNSNGSN; match class: 1 | Factor: SP2; motif: NNRRCCAATSRGNRNSNGSN; match class: 1 | 81 | 0.025173 | 1 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 169 | 0.028035 | 1 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 167 | 0.031477 | 1 |
| TF | TF:M02036_1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | 76 | 0.033548 | 1 |
| TF | TF:M11882_1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | 133 | 0.034724 | 1 |
| TF | TF:M07226 | Factor: SP1; motif: NCCCCKCCCCC | Factor: SP1; motif: NCCCCKCCCCC | 105 | 0.037620 | 1 |
| TF | TF:M02059 | Factor: ELK-1; motif: ACCGGAAGTN | Factor: ELK-1; motif: ACCGGAAGTN | 115 | 0.037767 | 1 |
| TF | TF:M11018 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | 173 | 0.038970 | 1 |
| TF | TF:M00933 | Factor: Sp1; motif: CCCCGCCCCN | Factor: Sp1; motif: CCCCGCCCCN | 118 | 0.041960 | 1 |
| TF | TF:M02089_1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | 115 | 0.045610 | 1 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 147 | 0.047182 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100315 | Lewy bodies | Lewy bodies | 7 | 0.000535 | 1 |
| HP | HP:0100314 | Cerebral inclusion bodies | Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain. | 8 | 0.002153 | 1 |
| HP | HP:0045007 | Abnormal substantia nigra morphology | A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry. | 5 | 0.039562 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 41 | 2.593921e-50 | 2 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 59 | 6.094068e-45 | 2 |
| GO:BP | GO:0042254 | ribosome biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] | 27 | 1.366166e-18 | 2 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 116 | 9.032324e-17 | 2 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 82 | 3.012648e-16 | 2 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 116 | 6.180808e-15 | 2 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 127 | 2.534073e-13 | 2 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 23 | 2.317368e-12 | 2 |
| GO:BP | GO:0045727 | positive regulation of translation | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] | 16 | 2.625735e-12 | 2 |
| GO:BP | GO:0042274 | ribosomal small subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 14 | 1.995071e-11 | 2 |
| GO:BP | GO:0006364 | rRNA processing | "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] | 18 | 2.995579e-11 | 2 |
| GO:BP | GO:0016072 | rRNA metabolic process | "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] | 19 | 4.239429e-11 | 2 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 116 | 6.447100e-11 | 2 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 125 | 8.860925e-11 | 2 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 19 | 7.468857e-10 | 2 |
| GO:BP | GO:1903312 | negative regulation of mRNA metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 12 | 8.771599e-09 | 2 |
| GO:BP | GO:2000767 | positive regulation of cytoplasmic translation | "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 7 | 1.126610e-08 | 2 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 35 | 1.926224e-08 | 2 |
| GO:BP | GO:0042255 | ribosome assembly | "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428] | 10 | 2.585233e-08 | 2 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 40 | 4.432601e-08 | 2 |
| GO:BP | GO:0070934 | CRD-mediated mRNA stabilization | "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] | 6 | 7.143748e-08 | 2 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 129 | 1.692876e-07 | 2 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 47 | 1.906542e-07 | 2 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 35 | 2.196593e-07 | 2 |
| GO:BP | GO:0043489 | RNA stabilization | "Prevention of degradation of RNA molecules." [GOC:go_curators] | 10 | 2.334353e-07 | 2 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 72 | 3.396272e-07 | 2 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 38 | 5.231686e-07 | 2 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 47 | 7.172856e-07 | 2 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 87 | 7.767929e-07 | 2 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 59 | 1.035659e-06 | 2 |
| GO:BP | GO:1902369 | negative regulation of RNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] | 10 | 1.106161e-06 | 2 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 56 | 1.368647e-06 | 2 |
| GO:BP | GO:0048255 | mRNA stabilization | "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid] | 9 | 1.728584e-06 | 2 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 52 | 1.870822e-06 | 2 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 39 | 2.729565e-06 | 2 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 50 | 4.434891e-06 | 2 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 54 | 5.090905e-06 | 2 |
| GO:BP | GO:0006402 | mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 14 | 5.559229e-06 | 2 |
| GO:BP | GO:1902373 | negative regulation of mRNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865] | 9 | 5.926879e-06 | 2 |
| GO:BP | GO:0043488 | regulation of mRNA stability | "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] | 12 | 7.314917e-06 | 2 |
| GO:BP | GO:2000765 | regulation of cytoplasmic translation | "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 7 | 9.000389e-06 | 2 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 17 | 1.078979e-05 | 2 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 45 | 1.392358e-05 | 2 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 80 | 1.433716e-05 | 2 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 51 | 1.442244e-05 | 2 |
| GO:BP | GO:1900151 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] | 6 | 1.459503e-05 | 2 |
| GO:BP | GO:0043487 | regulation of RNA stability | "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] | 12 | 1.509772e-05 | 2 |
| GO:BP | GO:1900152 | negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] | 5 | 1.846187e-05 | 2 |
| GO:BP | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc] | 8 | 1.896024e-05 | 2 |
| GO:BP | GO:0061013 | regulation of mRNA catabolic process | "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 12 | 2.011698e-05 | 2 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 45 | 2.967687e-05 | 2 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 24 | 3.642492e-05 | 2 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 76 | 4.233348e-05 | 2 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 87 | 4.428672e-05 | 2 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 33 | 4.854036e-05 | 2 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 33 | 4.993443e-05 | 2 |
| GO:BP | GO:0006401 | RNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 14 | 6.023407e-05 | 2 |
| GO:BP | GO:1901796 | regulation of signal transduction by p53 class mediator | "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 9 | 8.097690e-05 | 2 |
| GO:BP | GO:1903313 | positive regulation of mRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 10 | 9.731311e-05 | 2 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] | 25 | 1.440281e-04 | 2 |
| GO:BP | GO:0141188 | nucleic acid catabolic process | "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators] | 14 | 1.729504e-04 | 2 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 67 | 1.797896e-04 | 2 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 41 | 1.948685e-04 | 2 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 27 | 2.293958e-04 | 2 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 78 | 2.909998e-04 | 2 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 27 | 2.943272e-04 | 2 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 26 | 2.943531e-04 | 2 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 14 | 3.233305e-04 | 2 |
| GO:BP | GO:0022613 | ribonucleoprotein complex biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] | 33 | 3.673526e-04 | 2 |
| GO:BP | GO:0000956 | nuclear-transcribed mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] | 9 | 3.873615e-04 | 2 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 67 | 3.945828e-04 | 2 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 26 | 5.864322e-04 | 2 |
| GO:BP | GO:0050684 | regulation of mRNA processing | "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] | 9 | 6.124860e-04 | 2 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 10 | 6.730562e-04 | 2 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 41 | 7.649969e-04 | 2 |
| GO:BP | GO:0061157 | mRNA destabilization | "Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh] | 8 | 8.591867e-04 | 2 |
| GO:BP | GO:0042273 | ribosomal large subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 7 | 8.693056e-04 | 2 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 74 | 8.929827e-04 | 2 |
| GO:BP | GO:0000027 | ribosomal large subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428] | 5 | 9.277550e-04 | 2 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 23 | 9.809622e-04 | 2 |
| GO:BP | GO:0006325 | chromatin organization | "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] | 21 | 1.047046e-03 | 2 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 68 | 1.106930e-03 | 2 |
| GO:BP | GO:0050779 | RNA destabilization | "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai] | 8 | 1.154902e-03 | 2 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 47 | 1.208175e-03 | 2 |
| GO:BP | GO:0061014 | positive regulation of mRNA catabolic process | "Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 8 | 1.241124e-03 | 2 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 67 | 1.242376e-03 | 2 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 47 | 1.422214e-03 | 2 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 48 | 1.532391e-03 | 2 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 74 | 1.813159e-03 | 2 |
| GO:BP | GO:1901798 | positive regulation of signal transduction by p53 class mediator | "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 5 | 2.098757e-03 | 2 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 12 | 2.766593e-03 | 2 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 31 | 2.864281e-03 | 2 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 9 | 3.343296e-03 | 2 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 9 | 3.343296e-03 | 2 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 16 | 3.437698e-03 | 2 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 69 | 4.434961e-03 | 2 |
| GO:BP | GO:0010629 | negative regulation of gene expression | "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 29 | 4.616364e-03 | 2 |
| GO:BP | GO:0017148 | negative regulation of translation | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 8 | 6.079701e-03 | 2 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 20 | 6.311396e-03 | 2 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 15 | 6.843179e-03 | 2 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 21 | 7.980038e-03 | 2 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 12 | 8.273425e-03 | 2 |
| GO:BP | GO:0016071 | mRNA metabolic process | "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 33 | 9.514516e-03 | 2 |
| GO:BP | GO:0006396 | RNA processing | "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] | 44 | 9.531603e-03 | 2 |
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 9 | 9.817184e-03 | 2 |
| GO:BP | GO:0000028 | ribosomal small subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl, PMID:30467428] | 4 | 1.040862e-02 | 2 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 74 | 1.056996e-02 | 2 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 9 | 1.165624e-02 | 2 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 21 | 1.349588e-02 | 2 |
| GO:BP | GO:0034101 | erythrocyte homeostasis | "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] | 8 | 1.350363e-02 | 2 |
| GO:BP | GO:0010586 | miRNA metabolic process | "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] | 7 | 1.441785e-02 | 2 |
| GO:BP | GO:0006338 | chromatin remodeling | "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] | 17 | 1.619460e-02 | 2 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 25 | 1.764792e-02 | 2 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 12 | 2.068438e-02 | 2 |
| GO:BP | GO:0048024 | regulation of mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 7 | 2.071920e-02 | 2 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 7 | 2.071920e-02 | 2 |
| GO:BP | GO:0042752 | regulation of circadian rhythm | "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] | 7 | 2.326822e-02 | 2 |
| GO:BP | GO:0007623 | circadian rhythm | "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] | 9 | 2.497825e-02 | 2 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 16 | 2.746433e-02 | 2 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 15 | 3.012440e-02 | 2 |
| GO:BP | GO:0032873 | negative regulation of stress-activated MAPK cascade | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] | 3 | 4.484244e-02 | 2 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 18 | 4.960520e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0022626 | cytosolic ribosome | "A ribosome located in the cytosol." [GOC:mtg_sensu] | 35 | 3.082044e-47 | 2 |
| GO:CC | GO:0044391 | ribosomal subunit | "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl] | 35 | 5.825350e-39 | 2 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 111 | 9.051805e-29 | 2 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 111 | 9.185650e-29 | 2 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 101 | 1.665632e-27 | 2 |
| GO:CC | GO:0005840 | ribosome | "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] | 38 | 1.501430e-26 | 2 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 88 | 5.995653e-26 | 2 |
| GO:CC | GO:0022627 | cytosolic small ribosomal subunit | "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 17 | 1.966564e-24 | 2 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 106 | 2.449224e-24 | 2 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 106 | 2.449224e-24 | 2 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 106 | 2.449224e-24 | 2 |
| GO:CC | GO:0022625 | cytosolic large ribosomal subunit | "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 17 | 4.910553e-22 | 2 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 67 | 1.162536e-21 | 2 |
| GO:CC | GO:0015935 | small ribosomal subunit | "The smaller of the two subunits of a ribosome." [GOC:mah] | 18 | 4.646450e-21 | 2 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 122 | 4.690348e-20 | 2 |
| GO:CC | GO:0015934 | large ribosomal subunit | "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] | 17 | 3.879598e-16 | 2 |
| GO:CC | GO:0005730 | nucleolus | "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] | 50 | 2.922622e-15 | 2 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 142 | 7.681615e-15 | 2 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 83 | 2.442146e-14 | 2 |
| GO:CC | GO:0030684 | preribosome | "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] | 15 | 1.194981e-13 | 2 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 143 | 2.317379e-13 | 2 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 20 | 5.910155e-13 | 2 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 19 | 2.193849e-12 | 2 |
| GO:CC | GO:0010494 | cytoplasmic stress granule | "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] | 13 | 1.261005e-11 | 2 |
| GO:CC | GO:0032040 | small-subunit processome | "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] | 12 | 1.662623e-11 | 2 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 22 | 2.133128e-11 | 2 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 22 | 3.412128e-11 | 2 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 133 | 5.482469e-11 | 2 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 95 | 7.030358e-11 | 2 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 137 | 8.512479e-11 | 2 |
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 16 | 2.014235e-10 | 2 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 143 | 7.583319e-10 | 2 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 42 | 1.357402e-09 | 2 |
| GO:CC | GO:0071013 | catalytic step 2 spliceosome | "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 11 | 6.413164e-09 | 2 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 43 | 1.194210e-07 | 2 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 35 | 1.327239e-07 | 2 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 25 | 2.390743e-07 | 2 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 115 | 1.094559e-06 | 2 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 37 | 5.365642e-06 | 2 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 37 | 7.785478e-06 | 2 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 37 | 7.881646e-06 | 2 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 37 | 7.881646e-06 | 2 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 23 | 8.605698e-06 | 2 |
| GO:CC | GO:0016607 | nuclear speck | "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640] | 15 | 3.636675e-05 | 2 |
| GO:CC | GO:0016363 | nuclear matrix | "A dynamic, proteinaceous framework within the nucleus of eukaryotic cells, composed of proteins and RNA, that provides structural support for chromatin organization, gene regulation, and nuclear processes." [PMID:15608168, PMID:3058729, PMID:39789220] | 8 | 7.316384e-04 | 2 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 26 | 7.339474e-04 | 2 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 13 | 8.796265e-04 | 2 |
| GO:CC | GO:0005852 | eukaryotic translation initiation factor 3 complex | "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] | 4 | 1.040711e-03 | 2 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 25 | 1.379986e-03 | 2 |
| GO:CC | GO:0070937 | CRD-mediated mRNA stability complex | "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9." [GOC:mah, PMID:19029303] | 3 | 1.881610e-03 | 2 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 8 | 5.863106e-03 | 2 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 9 | 8.517368e-03 | 2 |
| GO:CC | GO:0034399 | nuclear periphery | "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah] | 4 | 1.460028e-02 | 2 |
| GO:CC | GO:0042555 | MCM complex | "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] | 3 | 1.515670e-02 | 2 |
| GO:CC | GO:0005791 | rough endoplasmic reticulum | "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] | 5 | 1.705364e-02 | 2 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 16 | 1.732939e-02 | 2 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 40 | 1.880812e-02 | 2 |
| GO:CC | GO:0042382 | paraspeckles | "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299] | 3 | 2.602191e-02 | 2 |
| GO:CC | GO:0005652 | nuclear lamina | "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363] | 3 | 3.296110e-02 | 2 |
| GO:CC | GO:0014069 | postsynaptic density | "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density] | 10 | 4.202939e-02 | 2 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 5 | 4.599752e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-156842 | Eukaryotic Translation Elongation | Eukaryotic Translation Elongation | 36 | 2.065748e-46 | 2 |
| REAC | REAC:R-HSA-156902 | Peptide chain elongation | Peptide chain elongation | 35 | 2.688332e-45 | 2 |
| REAC | REAC:R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | SRP-dependent cotranslational protein targeting to membrane | 37 | 8.913213e-45 | 2 |
| REAC | REAC:R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | L13a-mediated translational silencing of Ceruloplasmin expression | 36 | 4.130714e-43 | 2 |
| REAC | REAC:R-HSA-72689 | Formation of a pool of free 40S subunits | Formation of a pool of free 40S subunits | 35 | 5.570135e-43 | 2 |
| REAC | REAC:R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 34 | 3.333671e-42 | 2 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 36 | 7.534042e-42 | 2 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 36 | 7.534042e-42 | 2 |
| REAC | REAC:R-HSA-192823 | Viral mRNA Translation | Viral mRNA Translation | 33 | 1.864465e-41 | 2 |
| REAC | REAC:R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | GTP hydrolysis and joining of the 60S ribosomal subunit | 35 | 3.855438e-41 | 2 |
| REAC | REAC:R-HSA-72764 | Eukaryotic Translation Termination | Eukaryotic Translation Termination | 33 | 1.058851e-40 | 2 |
| REAC | REAC:R-HSA-2408557 | Selenocysteine synthesis | Selenocysteine synthesis | 33 | 1.058851e-40 | 2 |
| REAC | REAC:R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Response of EIF2AK4 (GCN2) to amino acid deficiency | 33 | 2.622844e-39 | 2 |
| REAC | REAC:R-HSA-927802 | Nonsense-Mediated Decay (NMD) | Nonsense-Mediated Decay (NMD) | 34 | 6.556590e-39 | 2 |
| REAC | REAC:R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 34 | 6.556590e-39 | 2 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 44 | 7.935755e-38 | 2 |
| REAC | REAC:R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Major pathway of rRNA processing in the nucleolus and cytosol | 38 | 1.041708e-37 | 2 |
| REAC | REAC:R-HSA-2408522 | Selenoamino acid metabolism | Selenoamino acid metabolism | 33 | 5.023338e-37 | 2 |
| REAC | REAC:R-HSA-8868773 | rRNA processing in the nucleus and cytosol | rRNA processing in the nucleus and cytosol | 38 | 9.380619e-37 | 2 |
| REAC | REAC:R-HSA-168273 | Influenza Viral RNA Transcription and Replication | Influenza Viral RNA Transcription and Replication | 34 | 1.297993e-36 | 2 |
| REAC | REAC:R-HSA-72312 | rRNA processing | rRNA processing | 38 | 7.432039e-36 | 2 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 57 | 2.031207e-35 | 2 |
| REAC | REAC:R-HSA-168255 | Influenza Infection | Influenza Infection | 34 | 3.241959e-34 | 2 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 34 | 1.540204e-32 | 2 |
| REAC | REAC:R-HSA-9711097 | Cellular response to starvation | Cellular response to starvation | 33 | 2.452229e-32 | 2 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 35 | 3.100336e-30 | 2 |
| REAC | REAC:R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | SARS-CoV-1 modulates host translation machinery | 17 | 2.873988e-22 | 2 |
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 19 | 1.623818e-21 | 2 |
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 19 | 2.356950e-21 | 2 |
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 18 | 6.010351e-21 | 2 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 33 | 4.743632e-20 | 2 |
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 18 | 8.608836e-20 | 2 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 37 | 1.672600e-18 | 2 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 43 | 3.442846e-18 | 2 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 43 | 6.770616e-18 | 2 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 37 | 7.841023e-18 | 2 |
| REAC | REAC:R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | SARS-CoV-2 modulates host translation machinery | 16 | 1.294062e-17 | 2 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 47 | 1.041013e-16 | 2 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 43 | 1.206993e-16 | 2 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 17 | 2.861706e-14 | 2 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 57 | 5.795057e-14 | 2 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 19 | 8.174023e-14 | 2 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 59 | 4.796703e-13 | 2 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 46 | 2.048788e-11 | 2 |
| REAC | REAC:R-HSA-9705683 | SARS-CoV-2-host interactions | SARS-CoV-2-host interactions | 16 | 6.967219e-08 | 2 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 18 | 4.182779e-07 | 2 |
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 15 | 9.554208e-07 | 2 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 15 | 1.528592e-06 | 2 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 16 | 9.458097e-06 | 2 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 20 | 1.741632e-05 | 2 |
| REAC | REAC:R-HSA-9629569 | Protein hydroxylation | Protein hydroxylation | 4 | 2.142524e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 99 | 1.055904e-44 | 2 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 114 | 1.899572e-36 | 2 |
| GO:MF | GO:0003735 | structural constituent of ribosome | "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] | 33 | 2.077772e-21 | 2 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 28 | 1.580514e-17 | 2 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 37 | 8.370824e-13 | 2 |
| GO:MF | GO:0019843 | rRNA binding | "Binding to a ribosomal RNA." [GOC:jl] | 12 | 3.682806e-11 | 2 |
| GO:MF | GO:0043021 | ribonucleoprotein complex binding | "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] | 14 | 1.786560e-08 | 2 |
| GO:MF | GO:0120545 | nucleic acid conformation isomerase activity | "Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-] | 13 | 1.655919e-07 | 2 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 136 | 2.710583e-07 | 2 |
| GO:MF | GO:0004386 | helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] | 12 | 1.039129e-06 | 2 |
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 10 | 5.920998e-06 | 2 |
| GO:MF | GO:0048027 | mRNA 5'-UTR binding | "Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid] | 6 | 9.541517e-06 | 2 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 14 | 1.407833e-05 | 2 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 37 | 9.875708e-05 | 2 |
| GO:MF | GO:0140517 | protein-RNA adaptor activity | "The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way." [PMID:24470144] | 5 | 1.230918e-04 | 2 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 41 | 1.730697e-04 | 2 |
| GO:MF | GO:0003724 | RNA helicase activity | "Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098] | 7 | 7.798951e-04 | 2 |
| GO:MF | GO:1990247 | N6-methyladenosine-containing RNA reader activity | "A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625] | 4 | 7.853388e-04 | 2 |
| GO:MF | GO:0008186 | ATP-dependent activity, acting on RNA | "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl] | 7 | 9.313757e-04 | 2 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 8 | 1.770502e-03 | 2 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 8 | 2.000253e-03 | 2 |
| GO:MF | GO:0031369 | translation initiation factor binding | "Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] | 5 | 2.703207e-03 | 2 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 14 | 2.961852e-03 | 2 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 13 | 5.285453e-03 | 2 |
| GO:MF | GO:0008312 | 7S RNA binding | "Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418] | 3 | 8.161035e-03 | 2 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 16 | 8.348916e-03 | 2 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 11 | 8.352271e-03 | 2 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 11 | 1.419419e-02 | 2 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 11 | 1.928630e-02 | 2 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 143 | 2.135991e-02 | 2 |
| GO:MF | GO:1990948 | ubiquitin ligase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a ubiquitin ligase." [GOC:dph, GOC:vw, PMID:21389117] | 3 | 2.754514e-02 | 2 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 15 | 2.773369e-02 | 2 |
| GO:MF | GO:0180051 | translation factor activity | "A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation." [GOC:pg] | 6 | 3.196013e-02 | 2 |
| GO:MF | GO:0160123 | structural constituent of nuclear lamina | "The action of a molecule that contributes to the structural integrity of nuclear lamina." [PMID:2824113, PMID:31434876] | 2 | 3.394531e-02 | 2 |
| GO:MF | GO:0003678 | DNA helicase activity | "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl] | 5 | 4.216693e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP477 | Cytoplasmic ribosomal proteins | Cytoplasmic ribosomal proteins | 33 | 3.180713e-40 | 2 |
| WP | WP:WP411 | mRNA processing | mRNA processing | 17 | 1.787957e-11 | 2 |
| WP | WP:WP3594 | Circadian rhythm genes | Circadian rhythm genes | 11 | 4.967024e-03 | 2 |
| WP | WP:WP107 | Translation factors | Translation factors | 6 | 5.164560e-03 | 2 |
| WP | WP:WP314 | Fas ligand pathway and stress induction of heat shock proteins | Fas ligand pathway and stress induction of heat shock proteins | 5 | 2.606525e-02 | 2 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 15 | 3.372225e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3055 | Nop56p-associated pre-rRNA complex | Nop56p-associated pre-rRNA complex | 36 | 1.733470e-34 | 2 |
| CORUM | CORUM:306 | Ribosome, cytoplasmic | Ribosome, cytoplasmic | 30 | 9.019141e-29 | 2 |
| CORUM | CORUM:338 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 15 | 2.423363e-15 | 2 |
| CORUM | CORUM:305 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 15 | 9.032243e-15 | 2 |
| CORUM | CORUM:308 | 60S ribosomal subunit, cytoplasmic | 60S ribosomal subunit, cytoplasmic | 15 | 3.604866e-12 | 2 |
| CORUM | CORUM:1332 | Large Drosha complex | Large Drosha complex | 6 | 1.026218e-03 | 2 |
| CORUM | CORUM:1181 | C complex spliceosome | C complex spliceosome | 10 | 2.616325e-03 | 2 |
| CORUM | CORUM:6838 | IGF2BP1 complex | IGF2BP1 complex | 4 | 7.243112e-03 | 2 |
| CORUM | CORUM:3082 | DGCR8 multiprotein complex | DGCR8 multiprotein complex | 4 | 1.184386e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03010 | Ribosome | Ribosome | 33 | 1.494760e-32 | 2 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | Coronavirus disease - COVID-19 | 34 | 1.131990e-27 | 2 |
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 11 | 3.298378e-04 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 68 | 1.727742e-19 | 2 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 93 | 4.163462e-18 | 2 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 97 | 6.992569e-18 | 2 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 62 | 1.590866e-17 | 2 |
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 66 | 1.545602e-16 | 2 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 104 | 1.327118e-15 | 2 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 62 | 1.412260e-15 | 2 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 51 | 2.840829e-15 | 2 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 51 | 7.713210e-15 | 2 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 55 | 8.745632e-15 | 2 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 46 | 1.637960e-14 | 2 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 48 | 2.201520e-14 | 2 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 48 | 3.600323e-14 | 2 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 75 | 4.961498e-14 | 2 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 91 | 5.305907e-14 | 2 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 54 | 6.145819e-14 | 2 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 51 | 9.248558e-14 | 2 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 51 | 1.524568e-13 | 2 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 101 | 2.124526e-13 | 2 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 68 | 6.740989e-13 | 2 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 104 | 9.076018e-13 | 2 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 91 | 1.175545e-12 | 2 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 113 | 1.862685e-12 | 2 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 82 | 2.408226e-12 | 2 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 24 | 4.866667e-12 | 2 |
| HPA | HPA:0620000 | Vagina | Vagina | 108 | 4.916687e-12 | 2 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 108 | 4.916687e-12 | 2 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 44 | 5.723037e-12 | 2 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 98 | 7.722867e-12 | 2 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 52 | 9.580054e-12 | 2 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 78 | 1.351237e-11 | 2 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 88 | 1.415738e-11 | 2 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 50 | 1.605639e-11 | 2 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 97 | 1.693318e-11 | 2 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 87 | 3.164109e-11 | 2 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 90 | 4.223964e-11 | 2 |
| HPA | HPA:0500653 | Soft tissue 1; fibroblasts[High] | Soft tissue 1; fibroblasts[High] | 30 | 5.632575e-11 | 2 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 87 | 6.114925e-11 | 2 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 112 | 6.290579e-11 | 2 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 106 | 1.068145e-10 | 2 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 49 | 1.091822e-10 | 2 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 95 | 1.286533e-10 | 2 |
| HPA | HPA:0380000 | Placenta | Placenta | 118 | 1.560129e-10 | 2 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 38 | 1.921062e-10 | 2 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 99 | 1.949539e-10 | 2 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 61 | 2.095416e-10 | 2 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 84 | 4.036909e-10 | 2 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 88 | 4.919924e-10 | 2 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 113 | 6.408389e-10 | 2 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 105 | 1.327721e-09 | 2 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 104 | 1.334824e-09 | 2 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 31 | 1.892737e-09 | 2 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 86 | 1.926431e-09 | 2 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 115 | 2.428495e-09 | 2 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 115 | 2.428495e-09 | 2 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 110 | 2.517117e-09 | 2 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 110 | 2.517117e-09 | 2 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 33 | 2.553958e-09 | 2 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 56 | 2.845994e-09 | 2 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 97 | 2.908089e-09 | 2 |
| HPA | HPA:0510703 | Soft tissue 2; peripheral nerve[High] | Soft tissue 2; peripheral nerve[High] | 21 | 3.304994e-09 | 2 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 116 | 3.807027e-09 | 2 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 31 | 4.080945e-09 | 2 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 82 | 5.267864e-09 | 2 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 37 | 7.666264e-09 | 2 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 84 | 1.003468e-08 | 2 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 78 | 1.028929e-08 | 2 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 31 | 1.141556e-08 | 2 |
| HPA | HPA:0630000 | Cervix | Cervix | 111 | 1.301638e-08 | 2 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 110 | 1.427122e-08 | 2 |
| HPA | HPA:0050000 | Breast | Breast | 113 | 1.542772e-08 | 2 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 26 | 1.707517e-08 | 2 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 55 | 1.823319e-08 | 2 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 29 | 2.060446e-08 | 2 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 109 | 2.092699e-08 | 2 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 34 | 2.143874e-08 | 2 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 30 | 2.265870e-08 | 2 |
| HPA | HPA:0160253 | Endometrium 1; cells in endometrial stroma[High] | Endometrium 1; cells in endometrial stroma[High] | 24 | 2.426342e-08 | 2 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 27 | 2.585472e-08 | 2 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 34 | 2.920882e-08 | 2 |
| HPA | HPA:0510653 | Soft tissue 2; fibroblasts[High] | Soft tissue 2; fibroblasts[High] | 26 | 3.247618e-08 | 2 |
| HPA | HPA:0050093 | Breast; myoepithelial cells[High] | Breast; myoepithelial cells[High] | 33 | 3.383878e-08 | 2 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 29 | 3.464808e-08 | 2 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 93 | 3.636790e-08 | 2 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 31 | 3.846018e-08 | 2 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 64 | 4.007532e-08 | 2 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 117 | 4.051457e-08 | 2 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 104 | 4.392792e-08 | 2 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 116 | 4.402449e-08 | 2 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 116 | 4.402449e-08 | 2 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 40 | 4.456160e-08 | 2 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 116 | 4.631583e-08 | 2 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 116 | 4.631583e-08 | 2 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 60 | 4.710351e-08 | 2 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 103 | 4.826236e-08 | 2 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 29 | 4.978834e-08 | 2 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 114 | 5.095224e-08 | 2 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 31 | 5.193611e-08 | 2 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 105 | 5.439616e-08 | 2 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 75 | 6.080953e-08 | 2 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 95 | 6.424568e-08 | 2 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 104 | 6.561757e-08 | 2 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 104 | 6.561757e-08 | 2 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 30 | 6.691384e-08 | 2 |
| HPA | HPA:0400000 | Rectum | Rectum | 118 | 6.828863e-08 | 2 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 93 | 6.877566e-08 | 2 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 109 | 7.542437e-08 | 2 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 109 | 7.542437e-08 | 2 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 104 | 8.955047e-08 | 2 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 112 | 9.146571e-08 | 2 |
| HPA | HPA:0060103 | Bronchus; respiratory epithelial cells[High] | Bronchus; respiratory epithelial cells[High] | 50 | 9.499572e-08 | 2 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 27 | 9.780558e-08 | 2 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 85 | 1.002430e-07 | 2 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 28 | 1.127228e-07 | 2 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 63 | 1.194000e-07 | 2 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 47 | 1.205411e-07 | 2 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 49 | 1.374743e-07 | 2 |
| HPA | HPA:0530000 | Spleen | Spleen | 100 | 1.436028e-07 | 2 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 112 | 1.516274e-07 | 2 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 26 | 1.681942e-07 | 2 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 109 | 1.871957e-07 | 2 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 109 | 1.871957e-07 | 2 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 89 | 2.151274e-07 | 2 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 109 | 2.300947e-07 | 2 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 88 | 2.976433e-07 | 2 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 34 | 3.041134e-07 | 2 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 105 | 3.338819e-07 | 2 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 105 | 3.338819e-07 | 2 |
| HPA | HPA:0630053 | Cervix; glandular cells[High] | Cervix; glandular cells[High] | 38 | 3.458484e-07 | 2 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 106 | 3.516189e-07 | 2 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 29 | 3.573773e-07 | 2 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 99 | 4.540046e-07 | 2 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 99 | 4.540046e-07 | 2 |
| HPA | HPA:0440343 | Skeletal muscle; myocytes[High] | Skeletal muscle; myocytes[High] | 32 | 4.900731e-07 | 2 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 114 | 6.025377e-07 | 2 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 114 | 6.025377e-07 | 2 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 92 | 6.097995e-07 | 2 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 96 | 6.367056e-07 | 2 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 116 | 6.636267e-07 | 2 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 19 | 6.748559e-07 | 2 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 30 | 6.833124e-07 | 2 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 27 | 6.921789e-07 | 2 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 33 | 7.379054e-07 | 2 |
| HPA | HPA:0570773 | Testis; peritubular cells[High] | Testis; peritubular cells[High] | 16 | 7.482257e-07 | 2 |
| HPA | HPA:0470683 | Skin 2; epidermal cells[High] | Skin 2; epidermal cells[High] | 35 | 7.672055e-07 | 2 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 21 | 7.877746e-07 | 2 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 116 | 8.651946e-07 | 2 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 30 | 9.186660e-07 | 2 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 30 | 1.002990e-06 | 2 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 107 | 1.065097e-06 | 2 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 106 | 1.093821e-06 | 2 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 112 | 1.154306e-06 | 2 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 109 | 1.187021e-06 | 2 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 38 | 1.195836e-06 | 2 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 112 | 1.253222e-06 | 2 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 28 | 1.284430e-06 | 2 |
| HPA | HPA:0490693 | Smooth muscle; smooth muscle cells[High] | Smooth muscle; smooth muscle cells[High] | 26 | 1.348121e-06 | 2 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 21 | 1.404515e-06 | 2 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 18 | 1.547000e-06 | 2 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 28 | 1.801119e-06 | 2 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 22 | 1.914613e-06 | 2 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 64 | 2.321144e-06 | 2 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 30 | 2.423231e-06 | 2 |
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 39 | 2.501908e-06 | 2 |
| HPA | HPA:0030053 | Appendix; glandular cells[High] | Appendix; glandular cells[High] | 48 | 2.623236e-06 | 2 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 31 | 2.624096e-06 | 2 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 61 | 2.700321e-06 | 2 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 96 | 2.733695e-06 | 2 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 24 | 2.998654e-06 | 2 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 15 | 3.071999e-06 | 2 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 100 | 3.169756e-06 | 2 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 108 | 3.411028e-06 | 2 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 32 | 3.473442e-06 | 2 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 27 | 3.638408e-06 | 2 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 78 | 4.078601e-06 | 2 |
| HPA | HPA:0351183 | Pancreas; pancreatic endocrine cells[High] | Pancreas; pancreatic endocrine cells[High] | 29 | 4.273141e-06 | 2 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 106 | 4.278329e-06 | 2 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 95 | 4.306663e-06 | 2 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 42 | 4.591748e-06 | 2 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 16 | 5.076848e-06 | 2 |
| HPA | HPA:0170253 | Endometrium 2; cells in endometrial stroma[High] | Endometrium 2; cells in endometrial stroma[High] | 19 | 5.202405e-06 | 2 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 98 | 5.947096e-06 | 2 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 24 | 6.158095e-06 | 2 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 15 | 6.178596e-06 | 2 |
| HPA | HPA:0340000 | Ovary | Ovary | 92 | 6.399302e-06 | 2 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 24 | 6.805654e-06 | 2 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 49 | 7.135880e-06 | 2 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 75 | 7.149079e-06 | 2 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 75 | 7.149079e-06 | 2 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 34 | 7.605270e-06 | 2 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 71 | 8.049236e-06 | 2 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 36 | 8.891796e-06 | 2 |
| HPA | HPA:0471492 | Skin 2; vascular mural cells[≥Medium] | Skin 2; vascular mural cells[≥Medium] | 14 | 9.020221e-06 | 2 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 11 | 9.406137e-06 | 2 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 12 | 1.021576e-05 | 2 |
| HPA | HPA:0010013 | Adipose tissue; adipocytes[High] | Adipose tissue; adipocytes[High] | 21 | 1.146934e-05 | 2 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 40 | 1.475434e-05 | 2 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 58 | 1.538542e-05 | 2 |
| HPA | HPA:0570783 | Testis; preleptotene spermatocytes[High] | Testis; preleptotene spermatocytes[High] | 27 | 1.678677e-05 | 2 |
| HPA | HPA:0080000 | Caudate | Caudate | 106 | 1.919565e-05 | 2 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 32 | 1.925197e-05 | 2 |
| HPA | HPA:0050013 | Breast; adipocytes[High] | Breast; adipocytes[High] | 17 | 1.944146e-05 | 2 |
| HPA | HPA:0530712 | Spleen; cells in red pulp[≥Medium] | Spleen; cells in red pulp[≥Medium] | 64 | 1.967620e-05 | 2 |
| HPA | HPA:0050012 | Breast; adipocytes[≥Medium] | Breast; adipocytes[≥Medium] | 40 | 2.029729e-05 | 2 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 108 | 2.058832e-05 | 2 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 110 | 2.264708e-05 | 2 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 46 | 2.409663e-05 | 2 |
| HPA | HPA:0400053 | Rectum; glandular cells[High] | Rectum; glandular cells[High] | 56 | 2.640789e-05 | 2 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 109 | 2.721604e-05 | 2 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 109 | 2.721604e-05 | 2 |
| HPA | HPA:0390000 | Prostate | Prostate | 103 | 2.774909e-05 | 2 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 103 | 2.774909e-05 | 2 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 92 | 2.908162e-05 | 2 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 85 | 2.950896e-05 | 2 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 17 | 3.076971e-05 | 2 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 84 | 3.097737e-05 | 2 |
| HPA | HPA:0400651 | Rectum; fibroblasts[≥Low] | Rectum; fibroblasts[≥Low] | 11 | 3.346290e-05 | 2 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 29 | 3.591256e-05 | 2 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 93 | 3.739689e-05 | 2 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 52 | 3.796376e-05 | 2 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 28 | 4.468939e-05 | 2 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 71 | 4.959352e-05 | 2 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 13 | 5.677306e-05 | 2 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 46 | 5.720391e-05 | 2 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 11 | 5.932707e-05 | 2 |
| HPA | HPA:0270353 | Kidney; cells in glomeruli[High] | Kidney; cells in glomeruli[High] | 28 | 6.144116e-05 | 2 |
| HPA | HPA:0130203 | Colon; endothelial cells[High] | Colon; endothelial cells[High] | 28 | 6.294633e-05 | 2 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 75 | 6.356642e-05 | 2 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 55 | 6.575330e-05 | 2 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 59 | 7.189876e-05 | 2 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 99 | 8.002232e-05 | 2 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 31 | 8.267179e-05 | 2 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 15 | 8.471564e-05 | 2 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 50 | 8.688145e-05 | 2 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 70 | 9.293815e-05 | 2 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 85 | 1.084809e-04 | 2 |
| HPA | HPA:0130000 | Colon | Colon | 116 | 1.285952e-04 | 2 |
| HPA | HPA:0300000 | Lung | Lung | 108 | 1.319702e-04 | 2 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 28 | 1.368519e-04 | 2 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 14 | 1.431740e-04 | 2 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 89 | 1.545982e-04 | 2 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 89 | 1.545982e-04 | 2 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 23 | 1.708955e-04 | 2 |
| HPA | HPA:0570782 | Testis; preleptotene spermatocytes[≥Medium] | Testis; preleptotene spermatocytes[≥Medium] | 38 | 1.880591e-04 | 2 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 22 | 1.970272e-04 | 2 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 75 | 2.109103e-04 | 2 |
| HPA | HPA:0460663 | Skin 1; keratinocytes[High] | Skin 1; keratinocytes[High] | 23 | 2.366317e-04 | 2 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 102 | 2.445602e-04 | 2 |
| HPA | HPA:0150053 | Duodenum; glandular cells[High] | Duodenum; glandular cells[High] | 54 | 2.714142e-04 | 2 |
| HPA | HPA:0100203 | Cerebral cortex; endothelial cells[High] | Cerebral cortex; endothelial cells[High] | 18 | 2.945939e-04 | 2 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 60 | 3.081632e-04 | 2 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 105 | 3.091434e-04 | 2 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 105 | 3.091434e-04 | 2 |
| HPA | HPA:0290000 | Liver | Liver | 97 | 3.180234e-04 | 2 |
| HPA | HPA:0510652 | Soft tissue 2; fibroblasts[≥Medium] | Soft tissue 2; fibroblasts[≥Medium] | 54 | 3.202203e-04 | 2 |
| HPA | HPA:0390053 | Prostate; glandular cells[High] | Prostate; glandular cells[High] | 35 | 3.211457e-04 | 2 |
| HPA | HPA:0030073 | Appendix; lymphoid tissue[High] | Appendix; lymphoid tissue[High] | 25 | 3.377614e-04 | 2 |
| HPA | HPA:0270362 | Kidney; cells in tubules[≥Medium] | Kidney; cells in tubules[≥Medium] | 92 | 3.793137e-04 | 2 |
| HPA | HPA:0030000 | Appendix | Appendix | 111 | 4.189709e-04 | 2 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 16 | 4.235891e-04 | 2 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 17 | 4.449295e-04 | 2 |
| HPA | HPA:0570771 | Testis; peritubular cells[≥Low] | Testis; peritubular cells[≥Low] | 24 | 4.460424e-04 | 2 |
| HPA | HPA:0461393 | Skin 1; cells in basal layer[High] | Skin 1; cells in basal layer[High] | 12 | 4.469961e-04 | 2 |
| HPA | HPA:0570772 | Testis; peritubular cells[≥Medium] | Testis; peritubular cells[≥Medium] | 20 | 4.737606e-04 | 2 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 90 | 4.922964e-04 | 2 |
| HPA | HPA:0530723 | Spleen; cells in white pulp[High] | Spleen; cells in white pulp[High] | 26 | 6.721036e-04 | 2 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 17 | 6.743477e-04 | 2 |
| HPA | HPA:0130651 | Colon; fibroblasts[≥Low] | Colon; fibroblasts[≥Low] | 9 | 8.120580e-04 | 2 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 71 | 8.819108e-04 | 2 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 78 | 8.822039e-04 | 2 |
| HPA | HPA:0500703 | Soft tissue 1; peripheral nerve[High] | Soft tissue 1; peripheral nerve[High] | 13 | 8.922759e-04 | 2 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 84 | 9.061400e-04 | 2 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 13 | 9.339436e-04 | 2 |
| HPA | HPA:0291163 | Liver; cholangiocytes[High] | Liver; cholangiocytes[High] | 15 | 9.359332e-04 | 2 |
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 79 | 1.010867e-03 | 2 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 36 | 1.044988e-03 | 2 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 79 | 1.135866e-03 | 2 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 13 | 1.222214e-03 | 2 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 18 | 1.327276e-03 | 2 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 90 | 1.348066e-03 | 2 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 78 | 1.354822e-03 | 2 |
| HPA | HPA:0360053 | Parathyroid gland; glandular cells[High] | Parathyroid gland; glandular cells[High] | 37 | 1.379241e-03 | 2 |
| HPA | HPA:0461452 | Skin 1; hair follicles[≥Medium] | Skin 1; hair follicles[≥Medium] | 14 | 1.512732e-03 | 2 |
| HPA | HPA:0130892 | Colon; goblet cells[≥Medium] | Colon; goblet cells[≥Medium] | 15 | 1.572053e-03 | 2 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 88 | 1.628645e-03 | 2 |
| HPA | HPA:0270000 | Kidney | Kidney | 113 | 2.060063e-03 | 2 |
| HPA | HPA:0400052 | Rectum; glandular cells[≥Medium] | Rectum; glandular cells[≥Medium] | 93 | 2.166051e-03 | 2 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 89 | 2.585673e-03 | 2 |
| HPA | HPA:0570000 | Testis | Testis | 119 | 2.623129e-03 | 2 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 76 | 2.772165e-03 | 2 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 83 | 2.950776e-03 | 2 |
| HPA | HPA:0400242 | Rectum; peripheral nerve/ganglion[≥Medium] | Rectum; peripheral nerve/ganglion[≥Medium] | 11 | 2.984468e-03 | 2 |
| HPA | HPA:0090183 | Cerebellum; cells in granular layer[High] | Cerebellum; cells in granular layer[High] | 23 | 3.089267e-03 | 2 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 15 | 3.147152e-03 | 2 |
| HPA | HPA:0510702 | Soft tissue 2; peripheral nerve[≥Medium] | Soft tissue 2; peripheral nerve[≥Medium] | 36 | 3.272773e-03 | 2 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 88 | 3.280822e-03 | 2 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 14 | 3.331386e-03 | 2 |
| HPA | HPA:0570803 | Testis; sertoli cells[High] | Testis; sertoli cells[High] | 20 | 3.596525e-03 | 2 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 86 | 3.624997e-03 | 2 |
| HPA | HPA:0530713 | Spleen; cells in red pulp[High] | Spleen; cells in red pulp[High] | 24 | 3.854790e-03 | 2 |
| HPA | HPA:0400891 | Rectum; goblet cells[≥Low] | Rectum; goblet cells[≥Low] | 16 | 4.117500e-03 | 2 |
| HPA | HPA:0500113 | Soft tissue 1; chondrocytes[High] | Soft tissue 1; chondrocytes[High] | 14 | 4.269679e-03 | 2 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 15 | 4.369534e-03 | 2 |
| HPA | HPA:0130891 | Colon; goblet cells[≥Low] | Colon; goblet cells[≥Low] | 16 | 4.373018e-03 | 2 |
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 41 | 4.414130e-03 | 2 |
| HPA | HPA:0461451 | Skin 1; hair follicles[≥Low] | Skin 1; hair follicles[≥Low] | 15 | 4.512356e-03 | 2 |
| HPA | HPA:0570791 | Testis; round or early spermatids[≥Low] | Testis; round or early spermatids[≥Low] | 47 | 4.535967e-03 | 2 |
| HPA | HPA:0461482 | Skin 1; sebaceous glands[≥Medium] | Skin 1; sebaceous glands[≥Medium] | 10 | 4.671371e-03 | 2 |
| HPA | HPA:0480053 | Small intestine; glandular cells[High] | Small intestine; glandular cells[High] | 50 | 4.706976e-03 | 2 |
| HPA | HPA:0130202 | Colon; endothelial cells[≥Medium] | Colon; endothelial cells[≥Medium] | 65 | 4.768517e-03 | 2 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 45 | 4.770619e-03 | 2 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 90 | 4.938486e-03 | 2 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 40 | 5.063700e-03 | 2 |
| HPA | HPA:0570792 | Testis; round or early spermatids[≥Medium] | Testis; round or early spermatids[≥Medium] | 41 | 5.151957e-03 | 2 |
| HPA | HPA:0400203 | Rectum; endothelial cells[High] | Rectum; endothelial cells[High] | 8 | 5.264139e-03 | 2 |
| HPA | HPA:0130053 | Colon; glandular cells[High] | Colon; glandular cells[High] | 48 | 5.557152e-03 | 2 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 111 | 5.713249e-03 | 2 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 84 | 5.737308e-03 | 2 |
| HPA | HPA:0270361 | Kidney; cells in tubules[≥Low] | Kidney; cells in tubules[≥Low] | 101 | 5.992588e-03 | 2 |
| HPA | HPA:0381192 | Placenta; cytotrophoblasts[≥Medium] | Placenta; cytotrophoblasts[≥Medium] | 16 | 6.225075e-03 | 2 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 15 | 6.379512e-03 | 2 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 12 | 6.456422e-03 | 2 |
| HPA | HPA:0131302 | Colon; enterocytes[≥Medium] | Colon; enterocytes[≥Medium] | 15 | 6.784266e-03 | 2 |
| HPA | HPA:0570761 | Testis; pachytene spermatocytes[≥Low] | Testis; pachytene spermatocytes[≥Low] | 47 | 7.126154e-03 | 2 |
| HPA | HPA:0151352 | Duodenum; paneth cells[≥Medium] | Duodenum; paneth cells[≥Medium] | 12 | 7.561878e-03 | 2 |
| HPA | HPA:0400201 | Rectum; endothelial cells[≥Low] | Rectum; endothelial cells[≥Low] | 12 | 8.173926e-03 | 2 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 10 | 8.568581e-03 | 2 |
| HPA | HPA:0400051 | Rectum; glandular cells[≥Low] | Rectum; glandular cells[≥Low] | 101 | 8.695341e-03 | 2 |
| HPA | HPA:0481351 | Small intestine; paneth cells[≥Low] | Small intestine; paneth cells[≥Low] | 12 | 1.027610e-02 | 2 |
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 40 | 1.043994e-02 | 2 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 12 | 1.107413e-02 | 2 |
| HPA | HPA:0130653 | Colon; fibroblasts[High] | Colon; fibroblasts[High] | 6 | 1.137771e-02 | 2 |
| HPA | HPA:0460642 | Skin 1; Langerhans[≥Medium] | Skin 1; Langerhans[≥Medium] | 50 | 1.178081e-02 | 2 |
| HPA | HPA:0400202 | Rectum; endothelial cells[≥Medium] | Rectum; endothelial cells[≥Medium] | 10 | 1.249309e-02 | 2 |
| HPA | HPA:0131292 | Colon; endocrine cells[≥Medium] | Colon; endocrine cells[≥Medium] | 15 | 1.261958e-02 | 2 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 72 | 1.325235e-02 | 2 |
| HPA | HPA:0481352 | Small intestine; paneth cells[≥Medium] | Small intestine; paneth cells[≥Medium] | 11 | 1.354613e-02 | 2 |
| HPA | HPA:0401303 | Rectum; enterocytes[High] | Rectum; enterocytes[High] | 11 | 1.410042e-02 | 2 |
| HPA | HPA:0241101 | Heart muscle; cardiomyocytes[≥Low] | Heart muscle; cardiomyocytes[≥Low] | 93 | 1.480491e-02 | 2 |
| HPA | HPA:0240000 | Heart muscle | Heart muscle | 93 | 1.480491e-02 | 2 |
| HPA | HPA:0031302 | Appendix; enterocytes[≥Medium] | Appendix; enterocytes[≥Medium] | 14 | 1.603188e-02 | 2 |
| HPA | HPA:0490692 | Smooth muscle; smooth muscle cells[≥Medium] | Smooth muscle; smooth muscle cells[≥Medium] | 56 | 1.654955e-02 | 2 |
| HPA | HPA:0460662 | Skin 1; keratinocytes[≥Medium] | Skin 1; keratinocytes[≥Medium] | 58 | 1.689009e-02 | 2 |
| HPA | HPA:0401301 | Rectum; enterocytes[≥Low] | Rectum; enterocytes[≥Low] | 17 | 1.761356e-02 | 2 |
| HPA | HPA:0461453 | Skin 1; hair follicles[High] | Skin 1; hair follicles[High] | 8 | 1.912907e-02 | 2 |
| HPA | HPA:0031292 | Appendix; endocrine cells[≥Medium] | Appendix; endocrine cells[≥Medium] | 14 | 1.913306e-02 | 2 |
| HPA | HPA:0151351 | Duodenum; paneth cells[≥Low] | Duodenum; paneth cells[≥Low] | 12 | 1.964017e-02 | 2 |
| HPA | HPA:0400653 | Rectum; fibroblasts[High] | Rectum; fibroblasts[High] | 6 | 2.015189e-02 | 2 |
| HPA | HPA:0381203 | Placenta; hofbauer cells[High] | Placenta; hofbauer cells[High] | 12 | 2.251432e-02 | 2 |
| HPA | HPA:0270352 | Kidney; cells in glomeruli[≥Medium] | Kidney; cells in glomeruli[≥Medium] | 55 | 2.448793e-02 | 2 |
| HPA | HPA:0381191 | Placenta; cytotrophoblasts[≥Low] | Placenta; cytotrophoblasts[≥Low] | 16 | 2.487168e-02 | 2 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 82 | 2.530684e-02 | 2 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 15 | 2.565797e-02 | 2 |
| HPA | HPA:0461481 | Skin 1; sebaceous glands[≥Low] | Skin 1; sebaceous glands[≥Low] | 10 | 2.613304e-02 | 2 |
| HPA | HPA:0241103 | Heart muscle; cardiomyocytes[High] | Heart muscle; cardiomyocytes[High] | 28 | 2.703443e-02 | 2 |
| HPA | HPA:0100202 | Cerebral cortex; endothelial cells[≥Medium] | Cerebral cortex; endothelial cells[≥Medium] | 47 | 2.758423e-02 | 2 |
| HPA | HPA:0381202 | Placenta; hofbauer cells[≥Medium] | Placenta; hofbauer cells[≥Medium] | 14 | 2.770128e-02 | 2 |
| HPA | HPA:0130652 | Colon; fibroblasts[≥Medium] | Colon; fibroblasts[≥Medium] | 7 | 2.814432e-02 | 2 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 13 | 2.879828e-02 | 2 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 13 | 2.879828e-02 | 2 |
| HPA | HPA:0150051 | Duodenum; glandular cells[≥Low] | Duodenum; glandular cells[≥Low] | 100 | 2.911132e-02 | 2 |
| HPA | HPA:0030891 | Appendix; goblet cells[≥Low] | Appendix; goblet cells[≥Low] | 14 | 3.093497e-02 | 2 |
| HPA | HPA:0211092 | Fallopian tube; non-ciliated cells[≥Medium] | Fallopian tube; non-ciliated cells[≥Medium] | 18 | 3.187075e-02 | 2 |
| HPA | HPA:0381201 | Placenta; hofbauer cells[≥Low] | Placenta; hofbauer cells[≥Low] | 15 | 3.235190e-02 | 2 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 44 | 3.262306e-02 | 2 |
| HPA | HPA:0480892 | Small intestine; goblet cells[≥Medium] | Small intestine; goblet cells[≥Medium] | 13 | 3.439024e-02 | 2 |
| HPA | HPA:0381193 | Placenta; cytotrophoblasts[High] | Placenta; cytotrophoblasts[High] | 12 | 3.450247e-02 | 2 |
| HPA | HPA:0401331 | Rectum; mucosal lymphoid cells[≥Low] | Rectum; mucosal lymphoid cells[≥Low] | 17 | 3.605672e-02 | 2 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 15 | 3.669285e-02 | 2 |
| HPA | HPA:0400893 | Rectum; goblet cells[High] | Rectum; goblet cells[High] | 10 | 3.893190e-02 | 2 |
| HPA | HPA:0131291 | Colon; endocrine cells[≥Low] | Colon; endocrine cells[≥Low] | 15 | 4.052299e-02 | 2 |
| HPA | HPA:0030051 | Appendix; glandular cells[≥Low] | Appendix; glandular cells[≥Low] | 96 | 4.153538e-02 | 2 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 76 | 4.238570e-02 | 2 |
| HPA | HPA:0130052 | Colon; glandular cells[≥Medium] | Colon; glandular cells[≥Medium] | 88 | 4.288418e-02 | 2 |
| HPA | HPA:0131303 | Colon; enterocytes[High] | Colon; enterocytes[High] | 10 | 4.709979e-02 | 2 |
| HPA | HPA:0400241 | Rectum; peripheral nerve/ganglion[≥Low] | Rectum; peripheral nerve/ganglion[≥Low] | 11 | 4.724019e-02 | 2 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 76 | 4.849177e-02 | 2 |
| HPA | HPA:0131301 | Colon; enterocytes[≥Low] | Colon; enterocytes[≥Low] | 16 | 4.925531e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 42 | 6.367541e-17 | 2 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 38 | 5.427229e-09 | 2 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 40 | 1.425739e-08 | 2 |
| MIRNA | MIRNA:hsa-mir-1296-5p | hsa-mir-1296-5p | hsa-mir-1296-5p | 10 | 3.526892e-05 | 2 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 16 | 1.780175e-04 | 2 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 19 | 3.140086e-04 | 2 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 22 | 9.389168e-04 | 2 |
| MIRNA | MIRNA:hsa-let-7c-3p | hsa-let-7c-3p | hsa-let-7c-3p | 8 | 9.479920e-04 | 2 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 33 | 3.403168e-03 | 2 |
| MIRNA | MIRNA:hsa-mir-15b-5p | hsa-mir-15b-5p | hsa-mir-15b-5p | 19 | 9.816458e-03 | 2 |
| MIRNA | MIRNA:hsa-mir-505-3p | hsa-mir-505-3p | hsa-mir-505-3p | 10 | 1.000833e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-652-3p | hsa-mir-652-3p | hsa-mir-652-3p | 8 | 1.090480e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-149-5p | hsa-mir-149-5p | hsa-mir-149-5p | 13 | 1.558902e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-92b-3p | hsa-mir-92b-3p | hsa-mir-92b-3p | 17 | 1.767277e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-6729-5p | hsa-mir-6729-5p | hsa-mir-6729-5p | 6 | 1.983651e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-524-5p | hsa-mir-524-5p | hsa-mir-524-5p | 36 | 2.954132e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-520d-5p | hsa-mir-520d-5p | hsa-mir-520d-5p | 36 | 2.984146e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-100-5p | hsa-mir-100-5p | hsa-mir-100-5p | 10 | 3.445859e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-191-5p | hsa-mir-191-5p | hsa-mir-191-5p | 6 | 3.506477e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-1273d | hsa-mir-1273d | hsa-mir-1273d | 16 | 4.557075e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002669 | Osteosarcoma | A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. | 10 | 1.385437e-09 | 2 |
| HP | HP:0002863 | Myelodysplasia | Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia. | 13 | 4.254601e-08 | 2 |
| HP | HP:0004808 | Acute myeloid leukemia | A form of leukemia characterized by overproduction of an early myeloid cell. | 11 | 1.375573e-07 | 2 |
| HP | HP:0012133 | Erythroid hypoplasia | Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 8 | 4.803033e-07 | 2 |
| HP | HP:0002488 | Acute leukemia | A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). | 12 | 1.316314e-06 | 2 |
| HP | HP:0012131 | Abnormal number of erythroid precursors | A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 9 | 1.605081e-06 | 2 |
| HP | HP:0011904 | Persistence of hemoglobin F | Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent. | 8 | 2.248507e-06 | 2 |
| HP | HP:0001895 | Normochromic anemia | Normochromic anemia | 8 | 3.530424e-06 | 2 |
| HP | HP:0031640 | Abnormal radial artery morphology | Any structural anomaly of the radial artery. | 7 | 4.861886e-06 | 2 |
| HP | HP:0030270 | Elevated red cell adenosine deaminase activity | Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine. | 7 | 4.861886e-06 | 2 |
| HP | HP:0020118 | Radial artery aplasia | Congenital absence of the radial artery. | 7 | 4.861886e-06 | 2 |
| HP | HP:4000209 | Abnormal erythrocyte adenosine deaminase activity | Activity of adenosine deaminase in red blood cells outside the limits of normal. | 7 | 6.514815e-06 | 2 |
| HP | HP:0001909 | Leukemia | A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. | 13 | 8.562434e-06 | 2 |
| HP | HP:0005532 | Macrocytic dyserythropoietic anemia | Macrocytic dyserythropoietic anemia | 7 | 8.621925e-06 | 2 |
| HP | HP:0001894 | Thrombocytosis | Increased numbers of platelets in the peripheral blood. | 9 | 1.457116e-05 | 2 |
| HP | HP:0012410 | Pure red cell aplasia | A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction. | 7 | 1.460492e-05 | 2 |
| HP | HP:0001227 | Abnormality of the thenar eminence | An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb. | 7 | 4.647703e-05 | 2 |
| HP | HP:0040276 | Adenocarcinoma of the colon | Adenocarcinoma of the colon | 7 | 4.647703e-05 | 2 |
| HP | HP:0000912 | Sprengel anomaly | A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other). | 8 | 5.342365e-05 | 2 |
| HP | HP:0006758 | Malignant genitourinary tract tumor | The presence of a malignant neoplasm of the genital system. | 7 | 5.726707e-05 | 2 |
| HP | HP:0011902 | Abnormal hemoglobin | Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes. | 9 | 5.857472e-05 | 2 |
| HP | HP:0100242 | Sarcoma | A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. | 12 | 6.923952e-05 | 2 |
| HP | HP:0010622 | Neoplasm of the skeletal system | A tumor (abnormal growth of tissue) of the skeleton. | 10 | 7.008294e-05 | 2 |
| HP | HP:0001896 | Reticulocytopenia | A reduced number of reticulocytes in the peripheral blood. | 7 | 7.010474e-05 | 2 |
| HP | HP:0009777 | Absent thumb | Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues. | 8 | 9.554282e-05 | 2 |
| HP | HP:0004377 | Hematological neoplasm | Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). | 15 | 1.006985e-04 | 2 |
| HP | HP:0040275 | Adenocarcinoma of the large intestine | A malignant epithelial tumor with a glandular organization that originates in the large intestine. | 7 | 1.031828e-04 | 2 |
| HP | HP:0000185 | Cleft soft palate | Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency. | 8 | 1.256563e-04 | 2 |
| HP | HP:0009944 | Partial duplication of thumb phalanx | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 7 | 1.769796e-04 | 2 |
| HP | HP:0040273 | Adenocarcinoma of the intestines | A malignant epithelial tumor with a glandular organization that originates in the intestines. | 7 | 2.098216e-04 | 2 |
| HP | HP:0001874 | Abnormality of neutrophils | A neutrophil abnormality. | 14 | 2.189188e-04 | 2 |
| HP | HP:0009999 | Partial duplication of the phalanx of hand | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 7 | 2.476635e-04 | 2 |
| HP | HP:0001911 | Abnormal granulocyte morphology | Any structural abnormality or abnormal count of granulocytes. | 15 | 2.625626e-04 | 2 |
| HP | HP:0009380 | Finger aplasia | A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers). | 9 | 2.824699e-04 | 2 |
| HP | HP:0030272 | Abnormal erythrocyte enzyme concentration or activity | An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme. | 7 | 5.348447e-04 | 2 |
| HP | HP:0001972 | Macrocytic anemia | A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH). | 8 | 6.671179e-04 | 2 |
| HP | HP:0010974 | Abnormal myeloid leukocyte morphology | An abnormality of myeloid leukocytes. | 15 | 7.672048e-04 | 2 |
| HP | HP:0001875 | Decreased total neutrophil count | Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group. | 12 | 7.701661e-04 | 2 |
| HP | HP:0008772 | Aplasia/Hypoplasia of the external ear | The presence of aplasia or developmental hypoplasia of all or part of the external ear. | 12 | 7.701661e-04 | 2 |
| HP | HP:0005518 | Increased mean corpuscular volume | Larger than normal size of erythrocytes. | 7 | 8.145479e-04 | 2 |
| HP | HP:0011893 | Abnormal leukocyte count | Number of leukocytes per volume of blood beyond normal limits. | 18 | 9.629036e-04 | 2 |
| HP | HP:0008771 | Aplasia/Hypoplasia of the ear | The presence of aplasia or developmental hypoplasia of the ear. | 12 | 1.099459e-03 | 2 |
| HP | HP:0001881 | Abnormal leukocyte morphology | An abnormality of leukocytes. | 20 | 1.285669e-03 | 2 |
| HP | HP:0010987 | Abnormal cellular immune system morphology | An abnormality of the morphology or counts of the cells that make up the immune system. | 20 | 1.285669e-03 | 2 |
| HP | HP:0100273 | Neoplasm of the colon | Neoplasm of the colon | 8 | 1.486592e-03 | 2 |
| HP | HP:0032309 | Abnormal granulocyte count | Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group. | 13 | 1.873473e-03 | 2 |
| HP | HP:0011991 | Abnormal total neutrophil count | A deviation from the normal range of neutrophil cell counts in the circulation. | 12 | 1.963041e-03 | 2 |
| HP | HP:0000294 | Low anterior hairline | Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella. | 10 | 2.046001e-03 | 2 |
| HP | HP:0009942 | Duplication of thumb phalanx | Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits. | 7 | 2.215142e-03 | 2 |
| HP | HP:0032251 | Abnormal immune system morphology | Abnormal immune system morphology | 20 | 2.508735e-03 | 2 |
| HP | HP:0008551 | Microtia | Underdevelopment of the external ear. | 11 | 2.550991e-03 | 2 |
| HP | HP:0025065 | Abnormal mean corpuscular volume | A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters. | 7 | 2.778964e-03 | 2 |
| HP | HP:0100037 | Abnormality of the scalp hair | An abnormality of the hair of head. | 16 | 2.995998e-03 | 2 |
| HP | HP:0009778 | Short thumb | Hypoplasia (congenital reduction in size) of the thumb. | 9 | 4.166345e-03 | 2 |
| HP | HP:0001790 | Nonimmune hydrops fetalis | A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens . | 7 | 4.271187e-03 | 2 |
| HP | HP:0001965 | Abnormal scalp morphology | Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows. | 16 | 4.981135e-03 | 2 |
| HP | HP:0000316 | Hypertelorism | Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes). | 22 | 5.822825e-03 | 2 |
| HP | HP:0001199 | Triphalangeal thumb | A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb. | 7 | 6.381086e-03 | 2 |
| HP | HP:0011792 | Neoplasm by histology | Neoplasm categorized according to type of histological abnormality. | 14 | 7.216925e-03 | 2 |
| HP | HP:0000599 | Abnormality of the frontal hairline | An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not. | 11 | 8.848550e-03 | 2 |
| HP | HP:0006749 | Malignant gastrointestinal tract tumors | Malignant gastrointestinal tract tumors | 7 | 1.017801e-02 | 2 |
| HP | HP:0001087 | Developmental glaucoma | Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma. | 7 | 1.017801e-02 | 2 |
| HP | HP:0002672 | Gastrointestinal carcinoma | Gastrointestinal carcinoma | 7 | 1.017801e-02 | 2 |
| HP | HP:0000519 | Developmental cataract | A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens. | 9 | 1.122651e-02 | 2 |
| HP | HP:0100736 | Abnormal soft palate morphology | An abnormality of the soft palate. | 12 | 1.248549e-02 | 2 |
| HP | HP:0011361 | Congenital abnormal hair pattern | A congenital abnormality of the distribution of hair growth. | 13 | 1.522978e-02 | 2 |
| HP | HP:0009601 | Aplasia/Hypoplasia of the thumb | Hypoplastic/small or absent thumb. | 9 | 1.664215e-02 | 2 |
| HP | HP:0000286 | Epicanthus | A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus. | 18 | 1.781809e-02 | 2 |
| HP | HP:0000085 | Horseshoe kidney | A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline. | 9 | 1.854980e-02 | 2 |
| HP | HP:0100834 | Neoplasm of the large intestine | The presence of a neoplasm of the large intestine. | 8 | 1.929984e-02 | 2 |
| HP | HP:0004312 | Abnormal reticulocyte morphology | A reticulocyte abnormality. | 7 | 2.171585e-02 | 2 |
| HP | HP:0000980 | Pallor | Abnormally pale skin. | 9 | 2.293198e-02 | 2 |
| HP | HP:0001882 | Decreased total leukocyte count | An abnormal decreased number of leukocytes in the blood. | 9 | 2.817041e-02 | 2 |
| HP | HP:0001671 | Abnormal cardiac septum morphology | An anomaly of the intra-atrial or intraventricular septum. | 20 | 3.020614e-02 | 2 |
| HP | HP:0000465 | Webbed neck | Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline. | 8 | 3.359190e-02 | 2 |
| HP | HP:0001421 | Abnormality of the musculature of the hand | Abnormality of the musculature of the hand | 8 | 4.234322e-02 | 2 |
| HP | HP:0001595 | Abnormal hair morphology | An abnormality of the hair. | 27 | 4.895559e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 130 | 3.596420e-07 | 2 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 138 | 4.133513e-06 | 2 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 136 | 1.045411e-05 | 2 |
| TF | TF:M04691_1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | 111 | 1.235364e-05 | 2 |
| TF | TF:M03977_1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | 66 | 1.805953e-05 | 2 |
| TF | TF:M01660 | Factor: GABP-alpha; motif: CTTCCK | Factor: GABP-alpha; motif: CTTCCK | 114 | 2.836109e-05 | 2 |
| TF | TF:M12600 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | 97 | 4.736730e-05 | 2 |
| TF | TF:M11435_1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | 74 | 6.087066e-05 | 2 |
| TF | TF:M09905 | Factor: SAP-1; motif: NNCCGGAAGTGN | Factor: SAP-1; motif: NNCCGGAAGTGN | 94 | 6.331392e-05 | 2 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 117 | 7.450437e-05 | 2 |
| TF | TF:M00025_1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | 62 | 1.002723e-04 | 2 |
| TF | TF:M11527_1 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1 | 81 | 1.007311e-04 | 2 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 138 | 1.239062e-04 | 2 |
| TF | TF:M02070 | Factor: TEL1; motif: CNCGGAANNN | Factor: TEL1; motif: CNCGGAANNN | 111 | 1.239528e-04 | 2 |
| TF | TF:M11430 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 111 | 1.410133e-04 | 2 |
| TF | TF:M00426_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 74 | 1.443654e-04 | 2 |
| TF | TF:M04710 | Factor: CHD2; motif: TCTCGCGAG | Factor: CHD2; motif: TCTCGCGAG | 130 | 1.616923e-04 | 2 |
| TF | TF:M02065_1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | 83 | 2.044843e-04 | 2 |
| TF | TF:M11527 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN | 82 | 2.136271e-04 | 2 |
| TF | TF:M00740 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | 108 | 2.242934e-04 | 2 |
| TF | TF:M13031 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 110 | 2.331529e-04 | 2 |
| TF | TF:M01078 | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | 87 | 2.346753e-04 | 2 |
| TF | TF:M04714 | Factor: Elf-1; motif: ACTTCCGGG | Factor: Elf-1; motif: ACTTCCGGG | 89 | 2.354402e-04 | 2 |
| TF | TF:M11400_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 59 | 2.439573e-04 | 2 |
| TF | TF:M02052 | Factor: EHF; motif: CSCGGAARTN | Factor: EHF; motif: CSCGGAARTN | 105 | 2.807609e-04 | 2 |
| TF | TF:M00940 | Factor: E2F-1; motif: NTTTCGCGCS | Factor: E2F-1; motif: NTTTCGCGCS | 89 | 2.918801e-04 | 2 |
| TF | TF:M03967 | Factor: ELF3; motif: WACCCGGAAGTAN | Factor: ELF3; motif: WACCCGGAAGTAN | 87 | 2.955405e-04 | 2 |
| TF | TF:M01660_1 | Factor: GABP-alpha; motif: CTTCCK; match class: 1 | Factor: GABP-alpha; motif: CTTCCK; match class: 1 | 67 | 3.126047e-04 | 2 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 122 | 3.583848e-04 | 2 |
| TF | TF:M00425_1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | 69 | 3.586988e-04 | 2 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 105 | 4.281590e-04 | 2 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 134 | 5.047927e-04 | 2 |
| TF | TF:M12601 | Factor: ELF4; motif: NCCACTTCCGGNNNN | Factor: ELF4; motif: NCCACTTCCGGNNNN | 71 | 5.375786e-04 | 2 |
| TF | TF:M11419 | Factor: ER81; motif: NNCCGGAWGYN | Factor: ER81; motif: NNCCGGAWGYN | 74 | 6.585730e-04 | 2 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 138 | 6.826671e-04 | 2 |
| TF | TF:M00940_1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | 43 | 6.854922e-04 | 2 |
| TF | TF:M00050 | Factor: E2F; motif: TTTSGCGC | Factor: E2F; motif: TTTSGCGC | 82 | 7.647476e-04 | 2 |
| TF | TF:M02068 | Factor: etv3; motif: ACCGGAAGYN | Factor: etv3; motif: ACCGGAAGYN | 51 | 7.706271e-04 | 2 |
| TF | TF:M11447 | Factor: Elf-1; motif: NAMCCGGAAGTN | Factor: Elf-1; motif: NAMCCGGAAGTN | 87 | 7.721085e-04 | 2 |
| TF | TF:M00333 | Factor: ZF5; motif: NRNGNGCGCGCWN | Factor: ZF5; motif: NRNGNGCGCGCWN | 134 | 8.521379e-04 | 2 |
| TF | TF:M08377_1 | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 | 65 | 9.591773e-04 | 2 |
| TF | TF:M00426 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 116 | 9.736605e-04 | 2 |
| TF | TF:M07380_1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | 89 | 1.116086e-03 | 2 |
| TF | TF:M02069 | Factor: Erm; motif: ACCGGAAGTN | Factor: Erm; motif: ACCGGAAGTN | 80 | 1.225148e-03 | 2 |
| TF | TF:M13032 | Factor: ETV5; motif: ACCGGAAGTN | Factor: ETV5; motif: ACCGGAAGTN | 99 | 1.236618e-03 | 2 |
| TF | TF:M03962_1 | Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT; match class: 1 | Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT; match class: 1 | 77 | 1.314268e-03 | 2 |
| TF | TF:M00025 | Factor: Elk-1; motif: NNNNCCGGAARTNN | Factor: Elk-1; motif: NNNNCCGGAARTNN | 103 | 1.361271e-03 | 2 |
| TF | TF:M04744_1 | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 | 63 | 1.432780e-03 | 2 |
| TF | TF:M11392_1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | 48 | 1.490209e-03 | 2 |
| TF | TF:M11450 | Factor: Elf-1; motif: NANSCGGAAGTR | Factor: Elf-1; motif: NANSCGGAAGTR | 69 | 1.846004e-03 | 2 |
| TF | TF:M03983 | Factor: ETV5; motif: NCCGGAWGYN | Factor: ETV5; motif: NCCGGAWGYN | 47 | 1.934948e-03 | 2 |
| TF | TF:M00737_1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | 45 | 2.032628e-03 | 2 |
| TF | TF:M11415 | Factor: GABP-alpha; motif: NRCCGGAAGTN | Factor: GABP-alpha; motif: NRCCGGAAGTN | 48 | 2.043117e-03 | 2 |
| TF | TF:M09901 | Factor: nerf; motif: NNNCCGGAAGTGN | Factor: nerf; motif: NNNCCGGAAGTGN | 67 | 2.044166e-03 | 2 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 141 | 2.185605e-03 | 2 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 138 | 2.268626e-03 | 2 |
| TF | TF:M11526_1 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1 | 78 | 2.519631e-03 | 2 |
| TF | TF:M08913 | Factor: FLI-1; motif: NAYTTCCGGT | Factor: FLI-1; motif: NAYTTCCGGT | 90 | 2.753463e-03 | 2 |
| TF | TF:M11451 | Factor: Elf-1; motif: NANCCGGAAGTN | Factor: Elf-1; motif: NANCCGGAAGTN | 79 | 3.103403e-03 | 2 |
| TF | TF:M04691 | Factor: Kaiso; motif: TCTCGCGAG | Factor: Kaiso; motif: TCTCGCGAG | 133 | 3.183294e-03 | 2 |
| TF | TF:M09966_1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | 15 | 3.258453e-03 | 2 |
| TF | TF:M02062_1 | Factor: Erg; motif: ACCGGAAGTN; match class: 1 | Factor: Erg; motif: ACCGGAAGTN; match class: 1 | 42 | 3.389674e-03 | 2 |
| TF | TF:M09606 | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | 74 | 3.457491e-03 | 2 |
| TF | TF:M02067 | Factor: ER71; motif: ACCGGAARYN | Factor: ER71; motif: ACCGGAARYN | 71 | 3.474637e-03 | 2 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 127 | 3.665642e-03 | 2 |
| TF | TF:M11414 | Factor: GABP-alpha; motif: NACCGGAAGTN | Factor: GABP-alpha; motif: NACCGGAAGTN | 44 | 3.822486e-03 | 2 |
| TF | TF:M13031_1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | 62 | 4.289759e-03 | 2 |
| TF | TF:M03982 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 78 | 4.368799e-03 | 2 |
| TF | TF:M13119 | Factor: ZBTB11; motif: RCTTCCGGNNSNNNN | Factor: ZBTB11; motif: RCTTCCGGNNSNNNN | 69 | 4.544323e-03 | 2 |
| TF | TF:M03990 | Factor: GABPA; motif: ACCGGAAGTN | Factor: GABPA; motif: ACCGGAAGTN | 65 | 4.582646e-03 | 2 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 60 | 4.664019e-03 | 2 |
| TF | TF:M11400 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 101 | 4.912942e-03 | 2 |
| TF | TF:M00425 | Factor: E2F; motif: TTTCGCGC | Factor: E2F; motif: TTTCGCGC | 109 | 4.943848e-03 | 2 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 138 | 5.362720e-03 | 2 |
| TF | TF:M11526 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN | 80 | 5.538169e-03 | 2 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 121 | 5.681706e-03 | 2 |
| TF | TF:M01770 | Factor: XBP-1; motif: WNNGMCACGTC | Factor: XBP-1; motif: WNNGMCACGTC | 108 | 5.721096e-03 | 2 |
| TF | TF:M11882_1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | 111 | 6.213878e-03 | 2 |
| TF | TF:M00803_1 | Factor: E2F; motif: GGCGSG; match class: 1 | Factor: E2F; motif: GGCGSG; match class: 1 | 103 | 6.319959e-03 | 2 |
| TF | TF:M11396_1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | 62 | 6.568086e-03 | 2 |
| TF | TF:M11452 | Factor: Elf-1; motif: NANGCGGAAGTR | Factor: Elf-1; motif: NANGCGGAAGTR | 73 | 6.982430e-03 | 2 |
| TF | TF:M04810 | Factor: USF2; motif: AAGTCACG | Factor: USF2; motif: AAGTCACG | 73 | 7.027081e-03 | 2 |
| TF | TF:M11428 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 80 | 7.120885e-03 | 2 |
| TF | TF:M11427 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 105 | 7.212559e-03 | 2 |
| TF | TF:M07415 | Factor: Elf-1; motif: AWCCCGGAAGTN | Factor: Elf-1; motif: AWCCCGGAAGTN | 86 | 7.876214e-03 | 2 |
| TF | TF:M08982 | Factor: YY1; motif: NAANATGGCGNNN | Factor: YY1; motif: NAANATGGCGNNN | 79 | 8.457677e-03 | 2 |
| TF | TF:M02066 | Factor: PEA3; motif: RCCGGAAGYN | Factor: PEA3; motif: RCCGGAAGYN | 79 | 8.457677e-03 | 2 |
| TF | TF:M02070_1 | Factor: TEL1; motif: CNCGGAANNN; match class: 1 | Factor: TEL1; motif: CNCGGAANNN; match class: 1 | 61 | 8.621576e-03 | 2 |
| TF | TF:M11434 | Factor: Elk-1; motif: NRSCGGAAGNN | Factor: Elk-1; motif: NRSCGGAAGNN | 88 | 8.737692e-03 | 2 |
| TF | TF:M07250 | Factor: E2F-1; motif: NNNSSCGCSAANN | Factor: E2F-1; motif: NNNSSCGCSAANN | 106 | 8.982911e-03 | 2 |
| TF | TF:M02063 | Factor: c-ets-1; motif: ACCGGAWGTN | Factor: c-ets-1; motif: ACCGGAWGTN | 83 | 9.158474e-03 | 2 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 104 | 9.212946e-03 | 2 |
| TF | TF:M11058_1 | Factor: Hey1; motif: NGCRCGYGYN; match class: 1 | Factor: Hey1; motif: NGCRCGYGYN; match class: 1 | 100 | 9.642427e-03 | 2 |
| TF | TF:M11448 | Factor: Elf-1; motif: NANGCGGAAGTN | Factor: Elf-1; motif: NANGCGGAAGTN | 83 | 1.030664e-02 | 2 |
| TF | TF:M11392 | Factor: Erg; motif: NACCGGAARYN | Factor: Erg; motif: NACCGGAARYN | 91 | 1.076668e-02 | 2 |
| TF | TF:M03977 | Factor: ETS1; motif: ACCGGAARYN | Factor: ETS1; motif: ACCGGAARYN | 104 | 1.106202e-02 | 2 |
| TF | TF:M11424 | Factor: Erm; motif: NNSCGGAWGYN | Factor: Erm; motif: NNSCGGAWGYN | 87 | 1.208071e-02 | 2 |
| TF | TF:M08913_1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | 44 | 1.209508e-02 | 2 |
| TF | TF:M02062 | Factor: Erg; motif: ACCGGAAGTN | Factor: Erg; motif: ACCGGAAGTN | 86 | 1.328513e-02 | 2 |
| TF | TF:M08875 | Factor: E2F; motif: NNTTTCGCGCN | Factor: E2F; motif: NNTTTCGCGCN | 72 | 1.340647e-02 | 2 |
| TF | TF:M11603_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 121 | 1.532191e-02 | 2 |
| TF | TF:M00024_1 | Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1 | Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1 | 40 | 1.566486e-02 | 2 |
| TF | TF:M02052_1 | Factor: EHF; motif: CSCGGAARTN; match class: 1 | Factor: EHF; motif: CSCGGAARTN; match class: 1 | 53 | 1.713458e-02 | 2 |
| TF | TF:M02090_1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | 73 | 1.885461e-02 | 2 |
| TF | TF:M11601 | Factor: TCF-1; motif: ACATCGRGRCGCTGW | Factor: TCF-1; motif: ACATCGRGRCGCTGW | 130 | 1.885493e-02 | 2 |
| TF | TF:M02059_1 | Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 | Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 | 50 | 2.115604e-02 | 2 |
| TF | TF:M12005_1 | Factor: GMEB-1; motif: KNACGTNRNNACGTAN; match class: 1 | Factor: GMEB-1; motif: KNACGTNRNNACGTAN; match class: 1 | 14 | 2.301338e-02 | 2 |
| TF | TF:M00333_1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | 116 | 2.332899e-02 | 2 |
| TF | TF:M01163 | Factor: Elk-1; motif: AACCGGAAGTR | Factor: Elk-1; motif: AACCGGAAGTR | 63 | 2.355139e-02 | 2 |
| TF | TF:M11422 | Factor: Erm; motif: NRCMGGAAGTN | Factor: Erm; motif: NRCMGGAAGTN | 58 | 2.406472e-02 | 2 |
| TF | TF:M00430_1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | 38 | 2.527208e-02 | 2 |
| TF | TF:M08759_1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | 42 | 2.601954e-02 | 2 |
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 126 | 2.671075e-02 | 2 |
| TF | TF:M08390_1 | Factor: A-Myb:Elf-1; motif: NMCCGGAACCGTTA; match class: 1 | Factor: A-Myb:Elf-1; motif: NMCCGGAACCGTTA; match class: 1 | 59 | 2.795796e-02 | 2 |
| TF | TF:M11018 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | 140 | 2.805447e-02 | 2 |
| TF | TF:M11531 | Factor: E2F-2; motif: GCGCGCGCGYW | Factor: E2F-2; motif: GCGCGCGCGYW | 121 | 2.900445e-02 | 2 |
| TF | TF:M11434_1 | Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 | Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 | 42 | 2.973485e-02 | 2 |
| TF | TF:M00430 | Factor: E2F-1; motif: NTTSGCGG | Factor: E2F-1; motif: NTTSGCGG | 85 | 2.991371e-02 | 2 |
| TF | TF:M00428 | Factor: E2F-1; motif: NKTSSCGC | Factor: E2F-1; motif: NKTSSCGC | 92 | 3.007608e-02 | 2 |
| TF | TF:M02059 | Factor: ELK-1; motif: ACCGGAAGTN | Factor: ELK-1; motif: ACCGGAAGTN | 95 | 3.066513e-02 | 2 |
| TF | TF:M01752_1 | Factor: ERG; motif: ACCGGAART; match class: 1 | Factor: ERG; motif: ACCGGAART; match class: 1 | 49 | 3.146985e-02 | 2 |
| TF | TF:M11428_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 34 | 3.213487e-02 | 2 |
| TF | TF:M11404_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 44 | 3.230201e-02 | 2 |
| TF | TF:M04519 | Factor: E2F-4; motif: TTTGGCGCCAAA | Factor: E2F-4; motif: TTTGGCGCCAAA | 59 | 3.233204e-02 | 2 |
| TF | TF:M11529 | Factor: E2F-2; motif: GCGCGCGCNCS | Factor: E2F-2; motif: GCGCGCGCNCS | 137 | 3.502682e-02 | 2 |
| TF | TF:M08525_1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | 132 | 3.536666e-02 | 2 |
| TF | TF:M00737 | Factor: E2F-1:DP-2; motif: TTTSSCGC | Factor: E2F-1:DP-2; motif: TTTSSCGC | 90 | 3.548276e-02 | 2 |
| TF | TF:M01820 | Factor: CREM; motif: TGACGTCASYN | Factor: CREM; motif: TGACGTCASYN | 71 | 3.617102e-02 | 2 |
| TF | TF:M02064 | Factor: c-ets-2; motif: ACCGGAWRTN | Factor: c-ets-2; motif: ACCGGAWRTN | 105 | 4.050649e-02 | 2 |
| TF | TF:M12600_1 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN; match class: 1 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN; match class: 1 | 44 | 4.095588e-02 | 2 |
| TF | TF:M04287 | Factor: BARHL2; motif: NNTAAAYGNN | Factor: BARHL2; motif: NNTAAAYGNN | 55 | 4.238586e-02 | 2 |
| TF | TF:M11221 | Factor: CREB1; motif: RTGACGYGTCAN | Factor: CREB1; motif: RTGACGYGTCAN | 96 | 4.241876e-02 | 2 |
| TF | TF:M00427_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 50 | 4.340926e-02 | 2 |
| TF | TF:M01145 | Factor: c-Myc; motif: RACCACGTGCTC | Factor: c-Myc; motif: RACCACGTGCTC | 70 | 4.742551e-02 | 2 |
| TF | TF:M07612 | Factor: PSF; motif: KWATCCGN | Factor: PSF; motif: KWATCCGN | 65 | 4.944993e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 63 | 9.064835e-10 | 3 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 49 | 1.697803e-07 | 3 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 33 | 9.221231e-07 | 3 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 33 | 1.313976e-06 | 3 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 33 | 1.329424e-06 | 3 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 33 | 1.329424e-06 | 3 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 93 | 1.795316e-06 | 3 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 107 | 5.422251e-05 | 3 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 33 | 9.496019e-05 | 3 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 33 | 1.002722e-04 | 3 |
| GO:CC | GO:0005662 | DNA replication factor A complex | "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] | 4 | 1.438981e-04 | 3 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 38 | 1.830272e-04 | 3 |
| GO:CC | GO:0043601 | nuclear replisome | "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] | 4 | 1.420914e-03 | 3 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 57 | 1.711555e-03 | 3 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 57 | 1.711555e-03 | 3 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 57 | 1.711555e-03 | 3 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 108 | 1.771412e-03 | 3 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 46 | 1.857295e-03 | 3 |
| GO:CC | GO:0030894 | replisome | "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] | 4 | 2.047879e-03 | 3 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 100 | 2.988437e-03 | 3 |
| GO:CC | GO:0048471 | perinuclear region of cytoplasm | "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] | 14 | 8.739041e-03 | 3 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 7 | 9.118080e-03 | 3 |
| GO:CC | GO:0030126 | COPI vesicle coat | "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894] | 3 | 1.156746e-02 | 3 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 40 | 1.221611e-02 | 3 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 40 | 1.242119e-02 | 3 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 5 | 1.333136e-02 | 3 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 15 | 1.604770e-02 | 3 |
| GO:CC | GO:0043596 | nuclear replication fork | "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] | 4 | 1.825542e-02 | 3 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 27 | 1.880832e-02 | 3 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 15 | 2.009778e-02 | 3 |
| GO:CC | GO:0099073 | mitochondrion-derived vesicle | "A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:18207745, PMID:20619655, PMID:22226745, PMID:23300790] | 2 | 2.504522e-02 | 3 |
| GO:CC | GO:0030663 | COPI-coated vesicle membrane | "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah] | 3 | 3.239504e-02 | 3 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 99 | 4.000304e-02 | 3 |
| GO:CC | GO:0005798 | Golgi-associated vesicle | "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] | 5 | 4.336752e-02 | 3 |
| GO:CC | GO:0098588 | bounding membrane of organelle | "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] | 25 | 4.613092e-02 | 3 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 16 | 4.680659e-02 | 3 |
| GO:CC | GO:0035861 | site of double-strand break | "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] | 5 | 4.779486e-02 | 3 |
| GO:CC | GO:0070522 | ERCC4-ERCC1 complex | "A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae." [PMID:14734547] | 2 | 4.992313e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 38 | 0.000003 | 3 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 45 | 0.000080 | 3 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 12 | 0.000467 | 3 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 27 | 0.000876 | 3 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 11 | 0.001564 | 3 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 18 | 0.001749 | 3 |
| GO:BP | GO:2001245 | regulation of phosphatidylcholine biosynthetic process | "Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol] | 3 | 0.002491 | 3 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 8 | 0.004164 | 3 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 27 | 0.004333 | 3 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 27 | 0.004502 | 3 |
| GO:BP | GO:0019637 | organophosphate metabolic process | "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] | 19 | 0.004747 | 3 |
| GO:BP | GO:0150003 | regulation of spontaneous synaptic transmission | "Any process that modulates the frequency, rate or extent of spontaneous synaptic transmission." [GOC:aruk, GOC:bc, PMID:15457210] | 3 | 0.004963 | 3 |
| GO:BP | GO:0006284 | base-excision repair | "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] | 5 | 0.007316 | 3 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 14 | 0.007454 | 3 |
| GO:BP | GO:0006289 | nucleotide-excision repair | "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] | 6 | 0.008541 | 3 |
| GO:BP | GO:0006753 | nucleoside phosphate metabolic process | "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] | 14 | 0.011704 | 3 |
| GO:BP | GO:0005975 | carbohydrate metabolic process | "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] | 13 | 0.012607 | 3 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 8 | 0.012876 | 3 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 29 | 0.018036 | 3 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 29 | 0.018477 | 3 |
| GO:BP | GO:0055086 | nucleobase-containing small molecule metabolic process | "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] | 14 | 0.018599 | 3 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 21 | 0.019946 | 3 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 69 | 0.022910 | 3 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 25 | 0.024359 | 3 |
| GO:BP | GO:0150172 | regulation of phosphatidylcholine metabolic process | "Any process that modulates the frequency, rate or extent of phosphatidylcholine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985] | 3 | 0.029329 | 3 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 17 | 0.029515 | 3 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 85 | 0.031101 | 3 |
| GO:BP | GO:0090407 | organophosphate biosynthetic process | "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg] | 13 | 0.035777 | 3 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 31 | 0.035834 | 3 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 31 | 0.039055 | 3 |
| GO:BP | GO:0009650 | UV protection | "Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml] | 3 | 0.040176 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 13 | 0.000026 | 3 |
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 7 | 0.000120 | 3 |
| GO:MF | GO:0005536 | D-glucose binding | "Binding to D-enantiomers of glucose." [GOC:jl] | 4 | 0.000237 | 3 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 61 | 0.000995 | 3 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 14 | 0.001693 | 3 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 61 | 0.003681 | 3 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 58 | 0.004770 | 3 |
| GO:MF | GO:0140431 | DNA-(abasic site) binding | "Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base." [PMID:23245849] | 2 | 0.016601 | 3 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 113 | 0.019336 | 3 |
| GO:MF | GO:0042162 | telomeric DNA binding | "Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624] | 4 | 0.031537 | 3 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 6 | 0.033976 | 3 |
| GO:MF | GO:0004177 | aminopeptidase activity | "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain." [EC:3.4.11.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837] | 4 | 0.034990 | 3 |
| GO:MF | GO:0048029 | monosaccharide binding | "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid] | 5 | 0.038219 | 3 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 101 | 0.042202 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | PCNA-Dependent Long Patch Base Excision Repair | 5 | 0.000276 | 3 |
| REAC | REAC:R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 5 | 0.000702 | 3 |
| REAC | REAC:R-HSA-69166 | Removal of the Flap Intermediate | Removal of the Flap Intermediate | 4 | 0.001788 | 3 |
| REAC | REAC:R-HSA-69183 | Processive synthesis on the lagging strand | Processive synthesis on the lagging strand | 4 | 0.002423 | 3 |
| REAC | REAC:R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | Removal of the Flap Intermediate from the C-strand | 4 | 0.004171 | 3 |
| REAC | REAC:R-HSA-73933 | Resolution of Abasic Sites (AP sites) | Resolution of Abasic Sites (AP sites) | 5 | 0.004635 | 3 |
| REAC | REAC:R-HSA-174414 | Processive synthesis on the C-strand of the telomere | Processive synthesis on the C-strand of the telomere | 4 | 0.006707 | 3 |
| REAC | REAC:R-HSA-6783310 | Fanconi Anemia Pathway | Fanconi Anemia Pathway | 5 | 0.006942 | 3 |
| REAC | REAC:R-HSA-69186 | Lagging Strand Synthesis | Lagging Strand Synthesis | 4 | 0.008331 | 3 |
| REAC | REAC:R-HSA-8863678 | Neurodegenerative Diseases | Neurodegenerative Diseases | 4 | 0.010227 | 3 |
| REAC | REAC:R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | 4 | 0.010227 | 3 |
| REAC | REAC:R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | Defective Intrinsic Pathway for Apoptosis | 4 | 0.017816 | 3 |
| REAC | REAC:R-HSA-5693532 | DNA Double-Strand Break Repair | DNA Double-Strand Break Repair | 8 | 0.034199 | 3 |
| REAC | REAC:R-HSA-3371511 | HSF1 activation | HSF1 activation | 3 | 0.049585 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 68 | 0.000826 | 3 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 71 | 0.001736 | 3 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 71 | 0.004184 | 3 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 78 | 0.004733 | 3 |
| HPA | HPA:0380000 | Placenta | Placenta | 76 | 0.007443 | 3 |
| HPA | HPA:0300000 | Lung | Lung | 75 | 0.008603 | 3 |
| HPA | HPA:0381202 | Placenta; hofbauer cells[≥Medium] | Placenta; hofbauer cells[≥Medium] | 12 | 0.010743 | 3 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 66 | 0.011363 | 3 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 69 | 0.011718 | 3 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 69 | 0.011718 | 3 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 73 | 0.013845 | 3 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 73 | 0.013845 | 3 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 65 | 0.014191 | 3 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 71 | 0.014554 | 3 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 71 | 0.014554 | 3 |
| HPA | HPA:0381191 | Placenta; cytotrophoblasts[≥Low] | Placenta; cytotrophoblasts[≥Low] | 13 | 0.021808 | 3 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 50 | 0.024311 | 3 |
| HPA | HPA:0630000 | Cervix | Cervix | 71 | 0.027934 | 3 |
| HPA | HPA:0270000 | Kidney | Kidney | 79 | 0.032705 | 3 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 74 | 0.033447 | 3 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 74 | 0.035035 | 3 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 69 | 0.038692 | 3 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 69 | 0.038692 | 3 |
| HPA | HPA:0381201 | Placenta; hofbauer cells[≥Low] | Placenta; hofbauer cells[≥Low] | 12 | 0.038923 | 3 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 73 | 0.044692 | 3 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 73 | 0.044692 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-let-7b-5p | hsa-let-7b-5p | hsa-let-7b-5p | 22 | 0.002337 | 3 |
| MIRNA | MIRNA:hsa-mir-30a-5p | hsa-mir-30a-5p | hsa-mir-30a-5p | 15 | 0.027808 | 3 |
| MIRNA | MIRNA:hsa-mir-629 | hsa-mir-629 | hsa-mir-629 | 16 | 0.044605 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03460 | Fanconi anemia pathway | Fanconi anemia pathway | 5 | 0.003427 | 3 |
| KEGG | KEGG:03420 | Nucleotide excision repair | Nucleotide excision repair | 5 | 0.006199 | 3 |
| KEGG | KEGG:03030 | DNA replication | DNA replication | 4 | 0.010310 | 3 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 6 | 0.034665 | 3 |
| KEGG | KEGG:03430 | Mismatch repair | Mismatch repair | 3 | 0.047829 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:832 | Anti-Sm protein complex | Anti-Sm protein complex | 3 | 0.005237 | 3 |
| CORUM | CORUM:5229 | RPA complex | RPA complex | 2 | 0.049954 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 104 | 0.008536 | 3 |
| TF | TF:M12173 | Factor: GKLF; motif: NNCCMCRCCCN | Factor: GKLF; motif: NNCCMCRCCCN | 81 | 0.011911 | 3 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 48 | 0.018735 | 3 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 96 | 0.026324 | 3 |
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 100 | 0.028723 | 3 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 95 | 0.029932 | 3 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 99 | 0.041627 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3875 | ATR signaling | ATR signaling | 3 | 0.010475 | 3 |
| WP | WP:WP5394 | UDP derived sugars synthesis in fibroblasts | UDP derived sugars synthesis in fibroblasts | 3 | 0.010475 | 3 |
| WP | WP:WP5173 | Disorders of galactose metabolism | Disorders of galactose metabolism | 3 | 0.017962 | 3 |
| WP | WP:WP5114 | Nucleotide excision repair in xeroderma pigmentosum | Nucleotide excision repair in xeroderma pigmentosum | 5 | 0.036492 | 3 |
| WP | WP:WP5372 | Involvement of secretase in neurodegenerative diseases | Involvement of secretase in neurodegenerative diseases | 3 | 0.041794 | 3 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 6 | 0.042094 | 3 |
| WP | WP:WP4753 | Nucleotide excision repair | Nucleotide excision repair | 4 | 0.047225 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 61 | 1.505513e-37 | 4 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 30 | 1.738853e-23 | 4 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 32 | 2.141248e-23 | 4 |
| GO:MF | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] | 42 | 1.072657e-22 | 4 |
| GO:MF | GO:0000987 | cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018] | 40 | 1.688649e-22 | 4 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 45 | 1.913659e-22 | 4 |
| GO:MF | GO:0000976 | transcription cis-regulatory region binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] | 43 | 2.899540e-22 | 4 |
| GO:MF | GO:0001067 | transcription regulatory region nucleic acid binding | "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] | 43 | 2.978506e-22 | 4 |
| GO:MF | GO:0001216 | DNA-binding transcription activator activity | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] | 29 | 3.221308e-22 | 4 |
| GO:MF | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018] | 39 | 1.051351e-21 | 4 |
| GO:MF | GO:0003700 | DNA-binding transcription factor activity | "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] | 42 | 1.242578e-21 | 4 |
| GO:MF | GO:1990837 | sequence-specific double-stranded DNA binding | "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] | 43 | 1.478118e-21 | 4 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 52 | 2.632457e-21 | 4 |
| GO:MF | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] | 41 | 2.730249e-21 | 4 |
| GO:MF | GO:0003690 | double-stranded DNA binding | "Binding to double-stranded DNA." [GOC:elh, GOC:vw] | 43 | 1.640564e-20 | 4 |
| GO:MF | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] | 27 | 8.226814e-20 | 4 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 34 | 3.915059e-16 | 4 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 30 | 3.289796e-14 | 4 |
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 20 | 3.563313e-14 | 4 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 40 | 9.976206e-14 | 4 |
| GO:MF | GO:0003712 | transcription coregulator activity | "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] | 20 | 2.523378e-11 | 4 |
| GO:MF | GO:0001217 | DNA-binding transcription repressor activity | "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets." [GOC:txnOH-2018] | 15 | 1.070667e-09 | 4 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 35 | 2.506363e-09 | 4 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 21 | 2.175086e-08 | 4 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 19 | 2.636482e-08 | 4 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 54 | 3.813064e-08 | 4 |
| GO:MF | GO:0001221 | transcription coregulator binding | "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] | 10 | 7.457672e-08 | 4 |
| GO:MF | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] | 13 | 1.349482e-07 | 4 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 89 | 7.857761e-07 | 4 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 18 | 1.465039e-06 | 4 |
| GO:MF | GO:0042826 | histone deacetylase binding | "Binding to histone deacetylase." [GOC:jl] | 9 | 3.224539e-06 | 4 |
| GO:MF | GO:0003713 | transcription coactivator activity | "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 10 | 1.155544e-04 | 4 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 11 | 1.266546e-04 | 4 |
| GO:MF | GO:0003714 | transcription corepressor activity | "A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 9 | 1.637632e-04 | 4 |
| GO:MF | GO:0043425 | bHLH transcription factor binding | "Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] | 5 | 1.687419e-04 | 4 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 10 | 6.581192e-04 | 4 |
| GO:MF | GO:0004842 | ubiquitin-protein transferase activity | "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] | 12 | 9.946008e-04 | 4 |
| GO:MF | GO:0001223 | transcription coactivator binding | "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] | 5 | 1.218891e-03 | 4 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 18 | 1.258714e-03 | 4 |
| GO:MF | GO:0019787 | ubiquitin-like protein transferase activity | "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] | 12 | 1.846726e-03 | 4 |
| GO:MF | GO:0016755 | aminoacyltransferase activity | "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] | 12 | 2.623136e-03 | 4 |
| GO:MF | GO:0017151 | DEAD/H-box RNA helicase binding | "Binding to a DEAD/H-box RNA helicase." [GOC:jl] | 3 | 2.718941e-03 | 4 |
| GO:MF | GO:0016746 | acyltransferase activity | "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-] | 14 | 5.254054e-03 | 4 |
| GO:MF | GO:0055106 | ubiquitin-protein transferase regulator activity | "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] | 4 | 7.945615e-03 | 4 |
| GO:MF | GO:0046332 | SMAD binding | "Binding to a SMAD signaling protein." [GOC:ai] | 5 | 1.599356e-02 | 4 |
| GO:MF | GO:0070411 | I-SMAD binding | "Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 3 | 2.648932e-02 | 4 |
| GO:MF | GO:0097027 | ubiquitin-protein transferase activator activity | "Binds to and increases the activity of a ubiquitin-protein transferase." [GOC:rb, PMID:18321851] | 3 | 2.648932e-02 | 4 |
| GO:MF | GO:0140693 | molecular condensate scaffold activity | "Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate." [PMID:28225081] | 4 | 2.776377e-02 | 4 |
| GO:MF | GO:0031490 | chromatin DNA binding | "Binding to DNA that is assembled into chromatin." [GOC:mah] | 6 | 3.336804e-02 | 4 |
| GO:MF | GO:0032810 | sterol response element binding | "Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism." [GOC:vk, PMID:11994399] | 2 | 3.357789e-02 | 4 |
| GO:MF | GO:0050816 | phosphothreonine residue binding | "Binding to a phosphorylated threonine residue within a protein." [GOC:ai] | 2 | 3.357789e-02 | 4 |
| GO:MF | GO:0043130 | ubiquitin binding | "Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd] | 5 | 4.961179e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 71 | 5.456450e-36 | 4 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 71 | 7.967376e-36 | 4 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 51 | 4.172873e-35 | 4 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 72 | 6.148538e-35 | 4 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 51 | 7.719994e-35 | 4 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 71 | 8.430487e-35 | 4 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 52 | 1.795561e-34 | 4 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 63 | 1.014317e-33 | 4 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 72 | 1.399713e-32 | 4 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 52 | 1.491602e-32 | 4 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 63 | 2.068257e-32 | 4 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 79 | 5.140622e-32 | 4 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 65 | 1.062718e-29 | 4 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 41 | 3.727776e-28 | 4 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 45 | 6.935189e-28 | 4 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 76 | 1.961010e-27 | 4 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 65 | 2.503999e-27 | 4 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 76 | 7.811633e-27 | 4 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 49 | 8.970496e-27 | 4 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 49 | 9.471991e-27 | 4 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 52 | 2.045767e-26 | 4 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 50 | 2.493622e-26 | 4 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 76 | 6.105955e-26 | 4 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 79 | 6.208696e-26 | 4 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 57 | 2.696138e-25 | 4 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 60 | 3.325313e-25 | 4 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 57 | 9.780993e-25 | 4 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 56 | 1.215740e-24 | 4 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 55 | 1.882711e-24 | 4 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 60 | 1.321343e-23 | 4 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 79 | 2.435299e-23 | 4 |
| GO:BP | GO:0045595 | regulation of cell differentiation | "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] | 42 | 1.830242e-20 | 4 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 69 | 1.582350e-19 | 4 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 70 | 4.080404e-19 | 4 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 69 | 1.438695e-18 | 4 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 48 | 1.514929e-18 | 4 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 73 | 3.459442e-18 | 4 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 73 | 8.270092e-18 | 4 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 72 | 1.042082e-17 | 4 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 70 | 1.386079e-17 | 4 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 75 | 1.886658e-17 | 4 |
| GO:BP | GO:0030154 | cell differentiation | "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] | 60 | 3.265488e-17 | 4 |
| GO:BP | GO:0048869 | cellular developmental process | "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] | 60 | 3.304395e-17 | 4 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 73 | 5.505422e-17 | 4 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 75 | 2.385480e-15 | 4 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 67 | 7.929073e-14 | 4 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 25 | 9.611242e-14 | 4 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 12 | 1.345167e-13 | 4 |
| GO:BP | GO:0051093 | negative regulation of developmental process | "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 28 | 1.802770e-13 | 4 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 13 | 1.879249e-13 | 4 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 77 | 5.748171e-13 | 4 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 63 | 8.755660e-13 | 4 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 46 | 9.511057e-13 | 4 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 12 | 9.976083e-13 | 4 |
| GO:BP | GO:0061614 | miRNA transcription | "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] | 12 | 1.177727e-12 | 4 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 78 | 1.559151e-12 | 4 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 11 | 1.677589e-12 | 4 |
| GO:BP | GO:0010586 | miRNA metabolic process | "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] | 13 | 1.722939e-12 | 4 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 36 | 1.784415e-12 | 4 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 86 | 2.051933e-12 | 4 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 51 | 2.913912e-12 | 4 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 34 | 6.815145e-12 | 4 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 34 | 7.442518e-12 | 4 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 36 | 8.387932e-12 | 4 |
| GO:BP | GO:0048732 | gland development | "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] | 20 | 9.232993e-12 | 4 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 29 | 2.076175e-11 | 4 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 36 | 2.312370e-11 | 4 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 36 | 2.460454e-11 | 4 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 80 | 2.907414e-11 | 4 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] | 43 | 4.063782e-11 | 4 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 84 | 4.139045e-11 | 4 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 25 | 4.241700e-11 | 4 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 25 | 9.323439e-11 | 4 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 35 | 2.249508e-10 | 4 |
| GO:BP | GO:0051094 | positive regulation of developmental process | "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 29 | 2.853365e-10 | 4 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 30 | 3.563254e-10 | 4 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 30 | 5.728414e-10 | 4 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 30 | 7.683923e-10 | 4 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] | 29 | 1.121097e-09 | 4 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 41 | 1.346714e-09 | 4 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] | 27 | 1.507495e-09 | 4 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 82 | 1.631543e-09 | 4 |
| GO:BP | GO:0016055 | Wnt signaling pathway | "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397] | 18 | 1.782084e-09 | 4 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 47 | 3.427434e-09 | 4 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 23 | 3.659508e-09 | 4 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 64 | 7.622172e-09 | 4 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 33 | 9.842741e-09 | 4 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 28 | 9.894611e-09 | 4 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 27 | 9.989690e-09 | 4 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 28 | 1.006081e-08 | 4 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] | 38 | 1.050484e-08 | 4 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 32 | 1.068661e-08 | 4 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 43 | 1.219521e-08 | 4 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 43 | 1.319314e-08 | 4 |
| GO:BP | GO:0007165 | signal transduction | "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] | 57 | 1.555461e-08 | 4 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 82 | 1.631814e-08 | 4 |
| GO:BP | GO:0034097 | response to cytokine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] | 23 | 1.671612e-08 | 4 |
| GO:BP | GO:1901652 | response to peptide | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] | 23 | 2.297434e-08 | 4 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] | 15 | 2.363176e-08 | 4 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 59 | 3.336797e-08 | 4 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 38 | 3.401088e-08 | 4 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 59 | 3.975301e-08 | 4 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 29 | 6.218495e-08 | 4 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 39 | 6.853695e-08 | 4 |
| GO:BP | GO:0048863 | stem cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] | 13 | 8.955163e-08 | 4 |
| GO:BP | GO:0060429 | epithelium development | "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] | 25 | 9.130959e-08 | 4 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 86 | 1.019563e-07 | 4 |
| GO:BP | GO:0072359 | circulatory system development | "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] | 24 | 1.148500e-07 | 4 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 69 | 1.351297e-07 | 4 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 82 | 1.626230e-07 | 4 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] | 23 | 2.641075e-07 | 4 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] | 19 | 2.718223e-07 | 4 |
| GO:BP | GO:0035295 | tube development | "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] | 23 | 3.399993e-07 | 4 |
| GO:BP | GO:0051148 | negative regulation of muscle cell differentiation | "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] | 8 | 5.218808e-07 | 4 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 26 | 8.958149e-07 | 4 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] | 21 | 9.810761e-07 | 4 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 25 | 1.005536e-06 | 4 |
| GO:BP | GO:0045444 | fat cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators] | 12 | 1.105388e-06 | 4 |
| GO:BP | GO:0048511 | rhythmic process | "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] | 13 | 1.341091e-06 | 4 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 17 | 1.575262e-06 | 4 |
| GO:BP | GO:0061061 | muscle structure development | "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] | 18 | 1.585896e-06 | 4 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 47 | 1.590373e-06 | 4 |
| GO:BP | GO:0001889 | liver development | "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] | 10 | 1.652614e-06 | 4 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] | 27 | 1.778671e-06 | 4 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 31 | 1.836366e-06 | 4 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 32 | 1.847941e-06 | 4 |
| GO:BP | GO:0061008 | hepaticobiliary system development | "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] | 10 | 2.014484e-06 | 4 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] | 12 | 2.106459e-06 | 4 |
| GO:BP | GO:0044092 | negative regulation of molecular function | "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 16 | 3.419379e-06 | 4 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 28 | 3.845203e-06 | 4 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 21 | 3.893281e-06 | 4 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 21 | 4.546474e-06 | 4 |
| GO:BP | GO:0071345 | cellular response to cytokine stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah] | 19 | 6.466839e-06 | 4 |
| GO:BP | GO:0006954 | inflammatory response | "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732] | 19 | 7.532335e-06 | 4 |
| GO:BP | GO:0071354 | cellular response to interleukin-6 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 6 | 9.780481e-06 | 4 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] | 22 | 1.033765e-05 | 4 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 13 | 1.340103e-05 | 4 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 19 | 1.723082e-05 | 4 |
| GO:BP | GO:0031347 | regulation of defense response | "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] | 18 | 1.803021e-05 | 4 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488] | 12 | 1.972564e-05 | 4 |
| GO:BP | GO:0070848 | response to growth factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah] | 17 | 2.129299e-05 | 4 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 34 | 2.181511e-05 | 4 |
| GO:BP | GO:0070741 | response to interleukin-6 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 6 | 2.466484e-05 | 4 |
| GO:BP | GO:0033993 | response to lipid | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] | 19 | 2.581109e-05 | 4 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 40 | 3.486388e-05 | 4 |
| GO:BP | GO:0030855 | epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] | 17 | 3.516621e-05 | 4 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 23 | 4.293942e-05 | 4 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 21 | 4.376203e-05 | 4 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 12 | 4.499760e-05 | 4 |
| GO:BP | GO:0071356 | cellular response to tumor necrosis factor | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] | 10 | 4.721484e-05 | 4 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] | 20 | 5.305739e-05 | 4 |
| GO:BP | GO:0030097 | hemopoiesis | "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] | 19 | 5.591529e-05 | 4 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 20 | 5.727491e-05 | 4 |
| GO:BP | GO:0035239 | tube morphogenesis | "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] | 18 | 6.450480e-05 | 4 |
| GO:BP | GO:0032501 | multicellular organismal process | "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] | 57 | 7.207456e-05 | 4 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah] | 16 | 7.600043e-05 | 4 |
| GO:BP | GO:0007507 | heart development | "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] | 15 | 9.158913e-05 | 4 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 40 | 9.944211e-05 | 4 |
| GO:BP | GO:0043434 | response to peptide hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] | 13 | 1.070703e-04 | 4 |
| GO:BP | GO:0050673 | epithelial cell proliferation | "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] | 13 | 1.099430e-04 | 4 |
| GO:BP | GO:0009790 | embryo development | "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] | 20 | 1.168219e-04 | 4 |
| GO:BP | GO:0034612 | response to tumor necrosis factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] | 10 | 1.172128e-04 | 4 |
| GO:BP | GO:0140467 | integrated stress response signaling | "The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041] | 6 | 1.253778e-04 | 4 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 9 | 1.474375e-04 | 4 |
| GO:BP | GO:0009887 | animal organ morphogenesis | "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544] | 19 | 1.573294e-04 | 4 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 10 | 1.750540e-04 | 4 |
| GO:BP | GO:0002521 | leukocyte differentiation | "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] | 15 | 1.758527e-04 | 4 |
| GO:BP | GO:0010647 | positive regulation of cell communication | "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 25 | 1.820135e-04 | 4 |
| GO:BP | GO:0023056 | positive regulation of signaling | "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 25 | 1.839918e-04 | 4 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 10 | 2.124530e-04 | 4 |
| GO:BP | GO:0060284 | regulation of cell development | "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] | 17 | 2.213929e-04 | 4 |
| GO:BP | GO:0060767 | epithelial cell proliferation involved in prostate gland development | "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph] | 4 | 2.300542e-04 | 4 |
| GO:BP | GO:0045598 | regulation of fat cell differentiation | "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] | 8 | 2.363244e-04 | 4 |
| GO:BP | GO:0050727 | regulation of inflammatory response | "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai] | 12 | 2.372183e-04 | 4 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] | 17 | 2.448892e-04 | 4 |
| GO:BP | GO:0062012 | regulation of small molecule metabolic process | "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] | 11 | 2.774178e-04 | 4 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194] | 18 | 2.845857e-04 | 4 |
| GO:BP | GO:0051090 | regulation of DNA-binding transcription factor activity | "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] | 11 | 2.953647e-04 | 4 |
| GO:BP | GO:0030879 | mammary gland development | "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833] | 8 | 3.325545e-04 | 4 |
| GO:BP | GO:0016567 | protein ubiquitination | "The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419] | 16 | 3.360876e-04 | 4 |
| GO:BP | GO:0006952 | defense response | "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] | 25 | 3.363467e-04 | 4 |
| GO:BP | GO:0043009 | chordate embryonic development | "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] | 15 | 3.515573e-04 | 4 |
| GO:BP | GO:0051147 | regulation of muscle cell differentiation | "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] | 8 | 3.921420e-04 | 4 |
| GO:BP | GO:0030324 | lung development | "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048] | 9 | 4.035785e-04 | 4 |
| GO:BP | GO:0030177 | positive regulation of Wnt signaling pathway | "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] | 8 | 4.367702e-04 | 4 |
| GO:BP | GO:0001701 | in utero embryonic development | "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] | 12 | 4.399214e-04 | 4 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 12 | 4.514877e-04 | 4 |
| GO:BP | GO:0030323 | respiratory tube development | "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid] | 9 | 4.782668e-04 | 4 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] | 10 | 5.079553e-04 | 4 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] | 15 | 5.219872e-04 | 4 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 24 | 5.225260e-04 | 4 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:22651914, PMID:28096268] | 11 | 5.724885e-04 | 4 |
| GO:BP | GO:0001890 | placenta development | "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] | 8 | 6.616641e-04 | 4 |
| GO:BP | GO:0007623 | circadian rhythm | "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] | 9 | 6.643976e-04 | 4 |
| GO:BP | GO:0060537 | muscle tissue development | "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph] | 12 | 6.773737e-04 | 4 |
| GO:BP | GO:0001503 | ossification | "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] | 12 | 6.773737e-04 | 4 |
| GO:BP | GO:0051145 | smooth muscle cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai] | 6 | 7.961667e-04 | 4 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 18 | 7.966644e-04 | 4 |
| GO:BP | GO:0040007 | growth | "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] | 17 | 8.187403e-04 | 4 |
| GO:BP | GO:0031398 | positive regulation of protein ubiquitination | "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 7 | 9.271404e-04 | 4 |
| GO:BP | GO:0010832 | negative regulation of myotube differentiation | "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] | 4 | 9.392019e-04 | 4 |
| GO:BP | GO:0001756 | somitogenesis | "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] | 6 | 9.553599e-04 | 4 |
| GO:BP | GO:0007178 | cell surface receptor protein serine/threonine kinase signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] | 11 | 1.003393e-03 | 4 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] | 11 | 1.003393e-03 | 4 |
| GO:BP | GO:0007517 | muscle organ development | "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] | 11 | 1.030985e-03 | 4 |
| GO:BP | GO:0051154 | negative regulation of striated muscle cell differentiation | "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] | 5 | 1.141879e-03 | 4 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 9 | 1.143706e-03 | 4 |
| GO:BP | GO:0060541 | respiratory system development | "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph] | 9 | 1.187223e-03 | 4 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] | 14 | 1.192850e-03 | 4 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 13 | 1.196078e-03 | 4 |
| GO:BP | GO:0071772 | response to BMP | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf] | 8 | 1.237844e-03 | 4 |
| GO:BP | GO:0071773 | cellular response to BMP stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf] | 8 | 1.237844e-03 | 4 |
| GO:BP | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb] | 6 | 1.242365e-03 | 4 |
| GO:BP | GO:0003188 | heart valve formation | "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] | 4 | 1.248175e-03 | 4 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] | 22 | 1.319828e-03 | 4 |
| GO:BP | GO:0002682 | regulation of immune system process | "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] | 22 | 1.362990e-03 | 4 |
| GO:BP | GO:1901698 | response to nitrogen compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 18 | 1.380789e-03 | 4 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 9 | 1.427037e-03 | 4 |
| GO:BP | GO:0003205 | cardiac chamber development | "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] | 8 | 1.484754e-03 | 4 |
| GO:BP | GO:0010665 | regulation of cardiac muscle cell apoptotic process | "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 5 | 1.498129e-03 | 4 |
| GO:BP | GO:0051707 | response to other organism | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] | 22 | 1.532616e-03 | 4 |
| GO:BP | GO:0043207 | response to external biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] | 22 | 1.582139e-03 | 4 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] | 17 | 1.604210e-03 | 4 |
| GO:BP | GO:0001649 | osteoblast differentiation | "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid] | 9 | 1.648069e-03 | 4 |
| GO:BP | GO:0001944 | vasculature development | "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] | 15 | 1.767911e-03 | 4 |
| GO:BP | GO:0007249 | canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217] | 10 | 1.816548e-03 | 4 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 14 | 1.851510e-03 | 4 |
| GO:BP | GO:0003170 | heart valve development | "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart] | 6 | 1.875559e-03 | 4 |
| GO:BP | GO:0048589 | developmental growth | "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] | 14 | 1.884952e-03 | 4 |
| GO:BP | GO:0010660 | regulation of muscle cell apoptotic process | "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 6 | 2.029362e-03 | 4 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] | 9 | 2.035073e-03 | 4 |
| GO:BP | GO:0061323 | cell proliferation involved in heart morphogenesis | "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart] | 4 | 2.084883e-03 | 4 |
| GO:BP | GO:0070102 | interleukin-6-mediated signaling pathway | "The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling] | 4 | 2.084883e-03 | 4 |
| GO:BP | GO:2000136 | regulation of cell proliferation involved in heart morphogenesis | "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] | 4 | 2.084883e-03 | 4 |
| GO:BP | GO:0038061 | non-canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217] | 7 | 2.122076e-03 | 4 |
| GO:BP | GO:0010659 | cardiac muscle cell apoptotic process | "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 5 | 2.191196e-03 | 4 |
| GO:BP | GO:0010662 | regulation of striated muscle cell apoptotic process | "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 5 | 2.191196e-03 | 4 |
| GO:BP | GO:0062197 | cellular response to chemical stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] | 10 | 2.358159e-03 | 4 |
| GO:BP | GO:0009607 | response to biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] | 22 | 2.375077e-03 | 4 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 14 | 2.413646e-03 | 4 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb] | 10 | 2.567657e-03 | 4 |
| GO:BP | GO:0019216 | regulation of lipid metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] | 10 | 2.567657e-03 | 4 |
| GO:BP | GO:0046890 | regulation of lipid biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] | 8 | 2.599086e-03 | 4 |
| GO:BP | GO:0031669 | cellular response to nutrient levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 9 | 2.671828e-03 | 4 |
| GO:BP | GO:0003231 | cardiac ventricle development | "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] | 7 | 2.782374e-03 | 4 |
| GO:BP | GO:0042692 | muscle cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] | 11 | 2.859381e-03 | 4 |
| GO:BP | GO:0014706 | striated muscle tissue development | "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle] | 11 | 3.072150e-03 | 4 |
| GO:BP | GO:0010658 | striated muscle cell apoptotic process | "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 5 | 3.115434e-03 | 4 |
| GO:BP | GO:0009628 | response to abiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] | 18 | 3.160677e-03 | 4 |
| GO:BP | GO:0010657 | muscle cell apoptotic process | "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 6 | 3.184348e-03 | 4 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 22 | 3.185875e-03 | 4 |
| GO:BP | GO:0022612 | gland morphogenesis | "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete] | 7 | 3.255421e-03 | 4 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 17 | 3.275679e-03 | 4 |
| GO:BP | GO:1901201 | regulation of extracellular matrix assembly | "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] | 4 | 3.279524e-03 | 4 |
| GO:BP | GO:2000138 | positive regulation of cell proliferation involved in heart morphogenesis | "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] | 3 | 3.415349e-03 | 4 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] | 7 | 3.427334e-03 | 4 |
| GO:BP | GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 7 | 3.427334e-03 | 4 |
| GO:BP | GO:1901875 | positive regulation of post-translational protein modification | "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 7 | 3.606783e-03 | 4 |
| GO:BP | GO:0061053 | somite development | "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph] | 6 | 3.936634e-03 | 4 |
| GO:BP | GO:0009605 | response to external stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] | 27 | 3.976177e-03 | 4 |
| GO:BP | GO:0048565 | digestive tract development | "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] | 7 | 4.193004e-03 | 4 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575] | 9 | 4.204824e-03 | 4 |
| GO:BP | GO:0032496 | response to lipopolysaccharide | "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464] | 10 | 4.313334e-03 | 4 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 17 | 4.370470e-03 | 4 |
| GO:BP | GO:0071396 | cellular response to lipid | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] | 13 | 4.618784e-03 | 4 |
| GO:BP | GO:0048729 | tissue morphogenesis | "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] | 13 | 4.702402e-03 | 4 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 8 | 4.705322e-03 | 4 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:mah] | 9 | 5.221761e-03 | 4 |
| GO:BP | GO:0035270 | endocrine system development | "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system] | 7 | 5.606481e-03 | 4 |
| GO:BP | GO:0030850 | prostate gland development | "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751] | 5 | 5.870207e-03 | 4 |
| GO:BP | GO:0072091 | regulation of stem cell proliferation | "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] | 6 | 5.877829e-03 | 4 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 13 | 6.023158e-03 | 4 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906] | 12 | 6.551539e-03 | 4 |
| GO:BP | GO:0002237 | response to molecule of bacterial origin | "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm] | 10 | 6.843127e-03 | 4 |
| GO:BP | GO:0033002 | muscle cell proliferation | "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah] | 8 | 7.049041e-03 | 4 |
| GO:BP | GO:0055123 | digestive system development | "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid] | 7 | 7.069866e-03 | 4 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 13 | 7.158965e-03 | 4 |
| GO:BP | GO:0000165 | MAPK cascade | "An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267] | 14 | 7.269851e-03 | 4 |
| GO:BP | GO:0045732 | positive regulation of protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] | 8 | 7.304201e-03 | 4 |
| GO:BP | GO:0032103 | positive regulation of response to external stimulus | "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] | 13 | 7.664105e-03 | 4 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 13 | 7.795234e-03 | 4 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 7 | 8.458569e-03 | 4 |
| GO:BP | GO:0003190 | atrioventricular valve formation | "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] | 3 | 9.503742e-03 | 4 |
| GO:BP | GO:0030509 | BMP signaling pathway | "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827] | 7 | 1.006769e-02 | 4 |
| GO:BP | GO:0045833 | negative regulation of lipid metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] | 6 | 1.019291e-02 | 4 |
| GO:BP | GO:0042594 | response to starvation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] | 8 | 1.031813e-02 | 4 |
| GO:BP | GO:0048568 | embryonic organ development | "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] | 11 | 1.036587e-02 | 4 |
| GO:BP | GO:0030856 | regulation of epithelial cell differentiation | "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] | 7 | 1.096324e-02 | 4 |
| GO:BP | GO:0002376 | immune system process | "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] | 29 | 1.122818e-02 | 4 |
| GO:BP | GO:0045165 | cell fate commitment | "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185] | 9 | 1.169874e-02 | 4 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 10 | 1.188539e-02 | 4 |
| GO:BP | GO:0001775 | cell activation | "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators] | 17 | 1.213896e-02 | 4 |
| GO:BP | GO:0072132 | mesenchyme morphogenesis | "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10] | 5 | 1.217840e-02 | 4 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 23 | 1.251594e-02 | 4 |
| GO:BP | GO:0001817 | regulation of cytokine production | "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149] | 14 | 1.269799e-02 | 4 |
| GO:BP | GO:0098542 | defense response to other organism | "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] | 18 | 1.270156e-02 | 4 |
| GO:BP | GO:0001666 | response to hypoxia | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] | 9 | 1.338835e-02 | 4 |
| GO:BP | GO:0033598 | mammary gland epithelial cell proliferation | "The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:mah] | 4 | 1.350123e-02 | 4 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 14 | 1.365738e-02 | 4 |
| GO:BP | GO:0001816 | cytokine production | "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] | 14 | 1.385683e-02 | 4 |
| GO:BP | GO:0090263 | positive regulation of canonical Wnt signaling pathway | "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] | 6 | 1.508767e-02 | 4 |
| GO:BP | GO:0062014 | negative regulation of small molecule metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] | 6 | 1.508767e-02 | 4 |
| GO:BP | GO:0003179 | heart valve morphogenesis | "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart] | 5 | 1.558310e-02 | 4 |
| GO:BP | GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number." [GOC:sj, PMID:18280719, PMID:32838963, PMID:36973360] | 4 | 1.561029e-02 | 4 |
| GO:BP | GO:0035886 | vascular associated smooth muscle cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954] | 4 | 1.561029e-02 | 4 |
| GO:BP | GO:0035282 | segmentation | "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689] | 6 | 1.592065e-02 | 4 |
| GO:BP | GO:0003279 | cardiac septum development | "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] | 6 | 1.592065e-02 | 4 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] | 8 | 1.678051e-02 | 4 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 9 | 1.740350e-02 | 4 |
| GO:BP | GO:0036293 | response to decreased oxygen levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] | 9 | 1.927662e-02 | 4 |
| GO:BP | GO:0060768 | regulation of epithelial cell proliferation involved in prostate gland development | "Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] | 3 | 2.023906e-02 | 4 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] | 7 | 2.081435e-02 | 4 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 27 | 2.145023e-02 | 4 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] | 11 | 2.265693e-02 | 4 |
| GO:BP | GO:0034248 | regulation of amide metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] | 5 | 2.286912e-02 | 4 |
| GO:BP | GO:0001655 | urogenital system development | "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] | 5 | 2.460125e-02 | 4 |
| GO:BP | GO:0034599 | cellular response to oxidative stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] | 8 | 2.488023e-02 | 4 |
| GO:BP | GO:0009267 | cellular response to starvation | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] | 7 | 2.509097e-02 | 4 |
| GO:BP | GO:0031667 | response to nutrient levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 11 | 2.578154e-02 | 4 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart] | 5 | 2.643418e-02 | 4 |
| GO:BP | GO:1902105 | regulation of leukocyte differentiation | "Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] | 9 | 2.725557e-02 | 4 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 28 | 2.898844e-02 | 4 |
| GO:BP | GO:0019221 | cytokine-mediated signaling pathway | "The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629] | 11 | 2.980631e-02 | 4 |
| GO:BP | GO:0001568 | blood vessel development | "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] | 13 | 3.135839e-02 | 4 |
| GO:BP | GO:1903706 | regulation of hemopoiesis | "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] | 10 | 3.151823e-02 | 4 |
| GO:BP | GO:0061180 | mammary gland epithelium development | "The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:yaf] | 5 | 3.257930e-02 | 4 |
| GO:BP | GO:0072089 | stem cell proliferation | "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] | 6 | 3.358744e-02 | 4 |
| GO:BP | GO:0030278 | regulation of ossification | "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] | 6 | 3.358744e-02 | 4 |
| GO:BP | GO:0003281 | ventricular septum development | "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] | 5 | 3.485744e-02 | 4 |
| GO:BP | GO:0048663 | neuron fate commitment | "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph] | 5 | 3.485744e-02 | 4 |
| GO:BP | GO:0042303 | molting cycle | "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732] | 6 | 3.517485e-02 | 4 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] | 6 | 3.517485e-02 | 4 |
| GO:BP | GO:0042633 | hair cycle | "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, PMID:12230507] | 6 | 3.517485e-02 | 4 |
| GO:BP | GO:0003157 | endocardium development | "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] | 3 | 3.687526e-02 | 4 |
| GO:BP | GO:0060379 | cardiac muscle cell myoblast differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb] | 3 | 3.687526e-02 | 4 |
| GO:BP | GO:0051150 | regulation of smooth muscle cell differentiation | "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] | 4 | 3.783932e-02 | 4 |
| GO:BP | GO:0070482 | response to oxygen levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] | 9 | 3.790209e-02 | 4 |
| GO:BP | GO:0010565 | regulation of ketone metabolic process | "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] | 6 | 4.030421e-02 | 4 |
| GO:BP | GO:0002268 | follicular dendritic cell differentiation | "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149] | 2 | 4.118008e-02 | 4 |
| GO:BP | GO:0061344 | regulation of cell adhesion involved in heart morphogenesis | "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] | 2 | 4.118008e-02 | 4 |
| GO:BP | GO:0003007 | heart morphogenesis | "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] | 8 | 4.249001e-02 | 4 |
| GO:BP | GO:0010721 | negative regulation of cell development | "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] | 8 | 4.365074e-02 | 4 |
| GO:BP | GO:0043433 | negative regulation of DNA-binding transcription factor activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl] | 6 | 4.602086e-02 | 4 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 8 | 4.729410e-02 | 4 |
| GO:BP | GO:0010944 | negative regulation of transcription by competitive promoter binding | "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site." [GOC:tb] | 3 | 4.778928e-02 | 4 |
| GO:BP | GO:0050810 | regulation of steroid biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai] | 5 | 4.817562e-02 | 4 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 38 | 4.962468e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 47 | 9.227367e-30 | 4 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 68 | 6.741429e-28 | 4 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 32 | 1.046378e-26 | 4 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 50 | 3.473233e-26 | 4 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 69 | 9.663815e-22 | 4 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 85 | 4.017113e-20 | 4 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 71 | 1.753341e-18 | 4 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 71 | 1.753341e-18 | 4 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 71 | 1.753341e-18 | 4 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 18 | 4.984545e-15 | 4 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 65 | 1.489984e-13 | 4 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 65 | 1.502184e-13 | 4 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 87 | 3.943719e-09 | 4 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 52 | 1.904522e-08 | 4 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 89 | 5.511524e-08 | 4 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 88 | 9.839377e-08 | 4 |
| GO:CC | GO:0017053 | transcription repressor complex | "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] | 8 | 3.672754e-07 | 4 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 89 | 2.972456e-06 | 4 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 58 | 1.835680e-05 | 4 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 90 | 3.092378e-05 | 4 |
| GO:CC | GO:0033256 | I-kappaB/NF-kappaB complex | "A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm." [GOC:bf, GOC:mah, PMID:9407099] | 3 | 8.059276e-05 | 4 |
| GO:CC | GO:0071159 | NF-kappaB complex | "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946] | 3 | 2.008815e-04 | 4 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 28 | 5.444813e-04 | 4 |
| GO:CC | GO:0071144 | heteromeric SMAD protein complex | "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] | 3 | 1.114914e-03 | 4 |
| GO:CC | GO:0071141 | SMAD protein complex | "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020] | 3 | 1.667391e-03 | 4 |
| GO:CC | GO:0033257 | Bcl3/NF-kappaB2 complex | "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099] | 2 | 5.028717e-03 | 4 |
| GO:CC | GO:1990647 | C/EBP complex | "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121] | 2 | 5.028717e-03 | 4 |
| GO:CC | GO:0035525 | NF-kappaB p50/p65 complex | "A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584] | 2 | 5.028717e-03 | 4 |
| GO:CC | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex | "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [CORUM:2949, PMID:16510869] | 2 | 1.504573e-02 | 4 |
| GO:CC | GO:0036488 | CHOP-C/EBP complex | "A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors." [GOC:bf, GOC:PARL, PMID:1547942] | 2 | 1.504573e-02 | 4 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 12 | 1.620850e-02 | 4 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 8 | 1.679979e-02 | 4 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 13 | 1.980218e-02 | 4 |
| GO:CC | GO:1990589 | ATF4-CREB1 transcription factor complex | "Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway." [GOC:bhm, PMID:12871976] | 2 | 3.001087e-02 | 4 |
| GO:CC | GO:0031461 | cullin-RING ubiquitin ligase complex | "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] | 6 | 4.038298e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 26 | 7.714921e-14 | 4 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 17 | 1.443708e-11 | 4 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 12 | 3.343580e-10 | 4 |
| KEGG | KEGG:04668 | TNF signaling pathway | TNF signaling pathway | 12 | 2.118817e-09 | 4 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | Transcriptional misregulation in cancer | 13 | 8.610991e-08 | 4 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 10 | 8.868204e-08 | 4 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 12 | 1.462483e-07 | 4 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 13 | 1.514043e-07 | 4 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | Chemical carcinogenesis - receptor activation | 13 | 2.743769e-07 | 4 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 9 | 2.987213e-07 | 4 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 12 | 1.433203e-06 | 4 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 8 | 6.045331e-06 | 4 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 14 | 7.455626e-06 | 4 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 10 | 9.082116e-06 | 4 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 10 | 1.404874e-05 | 4 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 8 | 3.490503e-05 | 4 |
| KEGG | KEGG:04380 | Osteoclast differentiation | Osteoclast differentiation | 9 | 3.849542e-05 | 4 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | Acute myeloid leukemia | 7 | 4.418549e-05 | 4 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 11 | 4.873655e-05 | 4 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | AGE-RAGE signaling pathway in diabetic complications | 8 | 5.191030e-05 | 4 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | C-type lectin receptor signaling pathway | 8 | 7.020425e-05 | 4 |
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 8 | 9.374659e-05 | 4 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 9 | 1.338573e-04 | 4 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 9 | 2.636376e-04 | 4 |
| KEGG | KEGG:04211 | Longevity regulating pathway | Longevity regulating pathway | 7 | 3.081430e-04 | 4 |
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | NF-kappa B signaling pathway | 7 | 7.658820e-04 | 4 |
| KEGG | KEGG:04659 | Th17 cell differentiation | Th17 cell differentiation | 7 | 9.276734e-04 | 4 |
| KEGG | KEGG:05224 | Breast cancer | Breast cancer | 8 | 9.460797e-04 | 4 |
| KEGG | KEGG:05219 | Bladder cancer | Bladder cancer | 5 | 9.545825e-04 | 4 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | TGF-beta signaling pathway | 7 | 1.050537e-03 | 4 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 6 | 1.142100e-03 | 4 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 8 | 1.530439e-03 | 4 |
| KEGG | KEGG:05030 | Cocaine addiction | Cocaine addiction | 5 | 2.320689e-03 | 4 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | Thyroid hormone signaling pathway | 7 | 2.345357e-03 | 4 |
| KEGG | KEGG:04310 | Wnt signaling pathway | Wnt signaling pathway | 8 | 3.213167e-03 | 4 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | Th1 and Th2 cell differentiation | 6 | 3.851041e-03 | 4 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 11 | 4.283737e-03 | 4 |
| KEGG | KEGG:05162 | Measles | Measles | 7 | 5.453187e-03 | 4 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | Ubiquitin mediated proteolysis | 7 | 5.974887e-03 | 4 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | MicroRNAs in cancer | 10 | 6.830830e-03 | 4 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 8 | 6.948530e-03 | 4 |
| KEGG | KEGG:04137 | Mitophagy - animal | Mitophagy - animal | 6 | 8.740793e-03 | 4 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | Parathyroid hormone synthesis, secretion and action | 6 | 9.725350e-03 | 4 |
| KEGG | KEGG:05216 | Thyroid cancer | Thyroid cancer | 4 | 1.235788e-02 | 4 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 7 | 1.277439e-02 | 4 |
| KEGG | KEGG:04917 | Prolactin signaling pathway | Prolactin signaling pathway | 5 | 1.306912e-02 | 4 |
| KEGG | KEGG:05218 | Melanoma | Melanoma | 5 | 1.493744e-02 | 4 |
| KEGG | KEGG:04024 | cAMP signaling pathway | cAMP signaling pathway | 8 | 1.824180e-02 | 4 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 6 | 2.024582e-02 | 4 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | Relaxin signaling pathway | 6 | 2.993473e-02 | 4 |
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 6 | 3.251295e-02 | 4 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 5 | 3.433565e-02 | 4 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 6 | 3.818950e-02 | 4 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | Estrogen signaling pathway | 6 | 3.972273e-02 | 4 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | IL-17 signaling pathway | 5 | 4.685940e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 26 | 3.995703e-12 | 4 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 11 | 3.962259e-09 | 4 |
| WP | WP:WP5144 | NRP1 triggered signaling in pancreatic cancer | NRP1 triggered signaling in pancreatic cancer | 9 | 8.479682e-08 | 4 |
| WP | WP:WP5272 | LDL influence on CD14 and TLR4 | LDL influence on CD14 and TLR4 | 7 | 9.529607e-08 | 4 |
| WP | WP:WP4331 | Neovascularization processes | Neovascularization processes | 8 | 1.067578e-07 | 4 |
| WP | WP:WP236 | Adipogenesis | Adipogenesis | 12 | 1.387554e-07 | 4 |
| WP | WP:WP1984 | Integrated breast cancer pathway | Integrated breast cancer pathway | 12 | 8.443352e-07 | 4 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 10 | 1.105959e-06 | 4 |
| WP | WP:WP4149 | White fat cell differentiation | White fat cell differentiation | 7 | 1.230399e-06 | 4 |
| WP | WP:WP2018 | RANKL RANK signaling | RANKL RANK signaling | 8 | 1.358290e-06 | 4 |
| WP | WP:WP4482 | Vitamin D in inflammatory diseases | Vitamin D in inflammatory diseases | 6 | 3.678825e-06 | 4 |
| WP | WP:WP3599 | Transcription factor regulation in adipogenesis | Transcription factor regulation in adipogenesis | 6 | 3.678825e-06 | 4 |
| WP | WP:WP4879 | Overlap between signal transduction pathways contributing to LMNA laminopathies | Overlap between signal transduction pathways contributing to LMNA laminopathies | 8 | 3.985148e-06 | 4 |
| WP | WP:WP138 | Androgen receptor signaling | Androgen receptor signaling | 9 | 6.331541e-06 | 4 |
| WP | WP:WP5474 | Catabolism of skeletal muscle in cachexia | Catabolism of skeletal muscle in cachexia | 7 | 6.453063e-06 | 4 |
| WP | WP:WP4211 | Transcriptional cascade regulating adipogenesis | Transcriptional cascade regulating adipogenesis | 5 | 8.377752e-06 | 4 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 8 | 1.017565e-05 | 4 |
| WP | WP:WP3981 | miRNA regulation of prostate cancer signaling | miRNA regulation of prostate cancer signaling | 6 | 3.415392e-05 | 4 |
| WP | WP:WP2112 | IL17 signaling | IL17 signaling | 6 | 4.175166e-05 | 4 |
| WP | WP:WP4754 | IL18 signaling | IL18 signaling | 7 | 7.196991e-05 | 4 |
| WP | WP:WP3617 | Photodynamic therapy induced NF kB survival signaling | Photodynamic therapy induced NF kB survival signaling | 6 | 7.327996e-05 | 4 |
| WP | WP:WP4844 | Influence of laminopathies on Wnt signaling | Influence of laminopathies on Wnt signaling | 6 | 1.035430e-04 | 4 |
| WP | WP:WP2036 | TNF related weak inducer of apoptosis TWEAK signaling | TNF related weak inducer of apoptosis TWEAK signaling | 6 | 1.221270e-04 | 4 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 8 | 1.253986e-04 | 4 |
| WP | WP:WP706 | Sudden infant death syndrome SIDS susceptibility pathways | Sudden infant death syndrome SIDS susceptibility pathways | 10 | 1.508318e-04 | 4 |
| WP | WP:WP5293 | Acute myeloid leukemia | Acute myeloid leukemia | 7 | 2.771937e-04 | 4 |
| WP | WP:WP2064 | Neural crest differentiation | Neural crest differentiation | 8 | 3.607195e-04 | 4 |
| WP | WP:WP2586 | Aryl hydrocarbon receptor pathway | Aryl hydrocarbon receptor pathway | 6 | 3.925112e-04 | 4 |
| WP | WP:WP615 | Senescence and autophagy in cancer | Senescence and autophagy in cancer | 8 | 4.842284e-04 | 4 |
| WP | WP:WP5477 | Molecular pathway for oxidative stress | Molecular pathway for oxidative stress | 6 | 5.741987e-04 | 4 |
| WP | WP:WP5353 | Macrophage stimulating protein MSP signaling | Macrophage stimulating protein MSP signaling | 8 | 5.989471e-04 | 4 |
| WP | WP:WP710 | DNA damage response only ATM dependent | DNA damage response only ATM dependent | 8 | 6.419812e-04 | 4 |
| WP | WP:WP5373 | Osteoarthritic chondrocyte hypertrophy | Osteoarthritic chondrocyte hypertrophy | 6 | 6.480950e-04 | 4 |
| WP | WP:WP4874 | CAMKK2 pathway | CAMKK2 pathway | 8 | 6.876121e-04 | 4 |
| WP | WP:WP61 | Notch signaling | Notch signaling | 6 | 8.191448e-04 | 4 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 8 | 8.413739e-04 | 4 |
| WP | WP:WP4659 | Gastrin signaling | Gastrin signaling | 8 | 8.987039e-04 | 4 |
| WP | WP:WP4666 | Hepatitis B infection | Hepatitis B infection | 9 | 9.117729e-04 | 4 |
| WP | WP:WP3858 | Toll like receptor signaling related to MyD88 | Toll like receptor signaling related to MyD88 | 5 | 9.807233e-04 | 4 |
| WP | WP:WP4262 | Breast cancer pathway | Breast cancer pathway | 9 | 1.014900e-03 | 4 |
| WP | WP:WP5113 | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway | 5 | 1.154607e-03 | 4 |
| WP | WP:WP2374 | Oncostatin M signaling | Oncostatin M signaling | 6 | 1.271497e-03 | 4 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 8 | 1.316959e-03 | 4 |
| WP | WP:WP3995 | Prion disease pathway | Prion disease pathway | 5 | 1.351736e-03 | 4 |
| WP | WP:WP2840 | Hair follicle development cytodifferentiation stage 3 of 3 | Hair follicle development cytodifferentiation stage 3 of 3 | 7 | 1.467711e-03 | 4 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 7 | 1.707227e-03 | 4 |
| WP | WP:WP2882 | Nuclear receptors meta pathway | Nuclear receptors meta pathway | 12 | 2.082441e-03 | 4 |
| WP | WP:WP2203 | Thymic stromal lymphopoietin TSLP signaling | Thymic stromal lymphopoietin TSLP signaling | 5 | 2.104590e-03 | 4 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 6 | 2.311603e-03 | 4 |
| WP | WP:WP5269 | Genetic causes of porto sinusoidal vascular disease | Genetic causes of porto sinusoidal vascular disease | 5 | 2.417253e-03 | 4 |
| WP | WP:WP4630 | Measles virus infection | Measles virus infection | 8 | 3.305988e-03 | 4 |
| WP | WP:WP2828 | Bladder cancer | Bladder cancer | 5 | 3.576680e-03 | 4 |
| WP | WP:WP5331 | Autophagy in pancreatic ductal adenocarcinoma | Autophagy in pancreatic ductal adenocarcinoma | 4 | 3.694282e-03 | 4 |
| WP | WP:WP4685 | Melanoma | Melanoma | 6 | 3.952001e-03 | 4 |
| WP | WP:WP1545 | miRNAs involved in DNA damage response | miRNAs involved in DNA damage response | 6 | 3.952001e-03 | 4 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 6 | 4.299202e-03 | 4 |
| WP | WP:WP4255 | Non small cell lung cancer | Non small cell lung cancer | 6 | 5.490693e-03 | 4 |
| WP | WP:WP5300 | TROP2 regulatory signaling | TROP2 regulatory signaling | 5 | 5.747786e-03 | 4 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 6 | 5.942076e-03 | 4 |
| WP | WP:WP4341 | Non genomic actions of 1 25 dihydroxyvitamin D3 | Non genomic actions of 1 25 dihydroxyvitamin D3 | 6 | 6.422795e-03 | 4 |
| WP | WP:WP712 | Estrogen signaling | Estrogen signaling | 4 | 6.621615e-03 | 4 |
| WP | WP:WP262 | Ebstein Barr virus LMP1 signaling | Ebstein Barr virus LMP1 signaling | 4 | 6.621615e-03 | 4 |
| WP | WP:WP1591 | Heart development | Heart development | 5 | 7.957798e-03 | 4 |
| WP | WP:WP28 | Selenium metabolism and selenoproteins | Selenium metabolism and selenoproteins | 5 | 7.957798e-03 | 4 |
| WP | WP:WP3926 | ApoE and miR 146 in inflammation and atherosclerosis | ApoE and miR 146 in inflammation and atherosclerosis | 3 | 8.321946e-03 | 4 |
| WP | WP:WP4480 | Altered glycosylation of MUC1 in tumor microenvironment | Altered glycosylation of MUC1 in tumor microenvironment | 3 | 8.321946e-03 | 4 |
| WP | WP:WP2431 | Spinal cord injury | Spinal cord injury | 7 | 9.092627e-03 | 4 |
| WP | WP:WP2895 | Differentiation of white and brown adipocyte | Differentiation of white and brown adipocyte | 4 | 9.337442e-03 | 4 |
| WP | WP:WP5205 | Clock controlled autophagy in bone metabolism | Clock controlled autophagy in bone metabolism | 6 | 1.000440e-02 | 4 |
| WP | WP:WP3611 | Photodynamic therapy induced AP 1 survival signaling | Photodynamic therapy induced AP 1 survival signaling | 5 | 1.077424e-02 | 4 |
| WP | WP:WP395 | IL4 signaling | IL4 signaling | 5 | 1.077424e-02 | 4 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 6 | 1.150122e-02 | 4 |
| WP | WP:WP5036 | Angiotensin II receptor type 1 pathway | Angiotensin II receptor type 1 pathway | 4 | 1.482205e-02 | 4 |
| WP | WP:WP254 | Apoptosis | Apoptosis | 6 | 1.603525e-02 | 4 |
| WP | WP:WP5098 | T cell activation SARS CoV 2 | T cell activation SARS CoV 2 | 6 | 1.709268e-02 | 4 |
| WP | WP:WP231 | TNF alpha signaling | TNF alpha signaling | 6 | 1.820488e-02 | 4 |
| WP | WP:WP3646 | Hepatitis C and hepatocellular carcinoma | Hepatitis C and hepatocellular carcinoma | 5 | 1.866363e-02 | 4 |
| WP | WP:WP4746 | Thyroid hormones production and peripheral downstream signaling effects | Thyroid hormones production and peripheral downstream signaling effects | 6 | 2.324297e-02 | 4 |
| WP | WP:WP3414 | Initiation of transcription and translation elongation at the HIV 1 LTR | Initiation of transcription and translation elongation at the HIV 1 LTR | 4 | 2.536537e-02 | 4 |
| WP | WP:WP1434 | Osteopontin signaling | Osteopontin signaling | 3 | 2.764284e-02 | 4 |
| WP | WP:WP5475 | Hallmark of cancer sustaining proliferative signaling | Hallmark of cancer sustaining proliferative signaling | 6 | 3.103152e-02 | 4 |
| WP | WP:WP4329 | miRNA role in immune response in sepsis | miRNA role in immune response in sepsis | 5 | 3.278005e-02 | 4 |
| WP | WP:WP3651 | Pathways affected in adenoid cystic carcinoma | Pathways affected in adenoid cystic carcinoma | 5 | 3.801221e-02 | 4 |
| WP | WP:WP2857 | Mesodermal commitment pathway | Mesodermal commitment pathway | 7 | 4.073755e-02 | 4 |
| WP | WP:WP2324 | AGE RAGE pathway | AGE RAGE pathway | 5 | 4.085540e-02 | 4 |
| WP | WP:WP5367 | Rubinstein Taybi syndrome 1 | Rubinstein Taybi syndrome 1 | 3 | 4.343790e-02 | 4 |
| WP | WP:WP3 | Transcriptional activation by NRF2 in response to phytochemicals | Transcriptional activation by NRF2 in response to phytochemicals | 3 | 4.343790e-02 | 4 |
| WP | WP:WP3594 | Circadian rhythm genes | Circadian rhythm genes | 8 | 4.995797e-02 | 4 |
| WP | WP:WP5087 | Pleural mesothelioma | Pleural mesothelioma | 12 | 4.999962e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 32 | 5.653939e-10 | 4 |
| REAC | REAC:R-HSA-9843745 | Adipogenesis | Adipogenesis | 12 | 1.943589e-09 | 4 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 34 | 5.090465e-09 | 4 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 32 | 7.156614e-09 | 4 |
| REAC | REAC:R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | Transcriptional regulation of white adipocyte differentiation | 10 | 5.869741e-08 | 4 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 22 | 1.830574e-06 | 4 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 22 | 2.526919e-06 | 4 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 9 | 3.060524e-05 | 4 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 20 | 3.880400e-05 | 4 |
| REAC | REAC:R-HSA-9818749 | Regulation of NFE2L2 gene expression | Regulation of NFE2L2 gene expression | 4 | 4.971318e-05 | 4 |
| REAC | REAC:R-HSA-8853884 | Transcriptional Regulation by VENTX | Transcriptional Regulation by VENTX | 6 | 7.714281e-05 | 4 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 26 | 1.444738e-04 | 4 |
| REAC | REAC:R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | Toll Like Receptor 3 (TLR3) Cascade | 8 | 1.480470e-04 | 4 |
| REAC | REAC:R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | TRIF (TICAM1)-mediated TLR4 signaling | 8 | 1.987215e-04 | 4 |
| REAC | REAC:R-HSA-166166 | MyD88-independent TLR4 cascade | MyD88-independent TLR4 cascade | 8 | 1.987215e-04 | 4 |
| REAC | REAC:R-HSA-2559583 | Cellular Senescence | Cellular Senescence | 10 | 2.215366e-04 | 4 |
| REAC | REAC:R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6 | 3.547250e-04 | 4 |
| REAC | REAC:R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 5 | 4.768981e-04 | 4 |
| REAC | REAC:R-HSA-8941326 | RUNX2 regulates bone development | RUNX2 regulates bone development | 5 | 5.693345e-04 | 4 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 8 | 6.136164e-04 | 4 |
| REAC | REAC:R-HSA-9616222 | Transcriptional regulation of granulopoiesis | Transcriptional regulation of granulopoiesis | 7 | 6.565285e-04 | 4 |
| REAC | REAC:R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 4 | 6.897790e-04 | 4 |
| REAC | REAC:R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins | SUMO E3 ligases SUMOylate target proteins | 9 | 7.557295e-04 | 4 |
| REAC | REAC:R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | Nuclear events stimulated by ALK signaling in cancer | 5 | 7.962764e-04 | 4 |
| REAC | REAC:R-HSA-2990846 | SUMOylation | SUMOylation | 9 | 1.004186e-03 | 4 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 7 | 1.190350e-03 | 4 |
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 7 | 1.190350e-03 | 4 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 8 | 1.231241e-03 | 4 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 7 | 1.369351e-03 | 4 |
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 5 | 1.460273e-03 | 4 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 11 | 1.550628e-03 | 4 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 4 | 1.615504e-03 | 4 |
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 4 | 1.615504e-03 | 4 |
| REAC | REAC:R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | Toll Like Receptor 4 (TLR4) Cascade | 8 | 1.791520e-03 | 4 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 5 | 1.924328e-03 | 4 |
| REAC | REAC:R-HSA-8849470 | PTK6 Regulates Cell Cycle | PTK6 Regulates Cell Cycle | 3 | 2.245144e-03 | 4 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 9 | 3.876826e-03 | 4 |
| REAC | REAC:R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 3 | 3.910265e-03 | 4 |
| REAC | REAC:R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | RUNX3 regulates CDKN1A transcription | 3 | 3.910265e-03 | 4 |
| REAC | REAC:R-HSA-5603029 | IkBA variant leads to EDA-ID | IkBA variant leads to EDA-ID | 3 | 3.910265e-03 | 4 |
| REAC | REAC:R-HSA-168898 | Toll-like Receptor Cascades | Toll-like Receptor Cascades | 8 | 5.148926e-03 | 4 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 5 | 5.614352e-03 | 4 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 5 | 5.614352e-03 | 4 |
| REAC | REAC:R-HSA-5689880 | Ub-specific processing proteases | Ub-specific processing proteases | 9 | 5.842852e-03 | 4 |
| REAC | REAC:R-HSA-9006936 | Signaling by TGFB family members | Signaling by TGFB family members | 7 | 6.260213e-03 | 4 |
| REAC | REAC:R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6 | 6.613131e-03 | 4 |
| REAC | REAC:R-HSA-448706 | Interleukin-1 processing | Interleukin-1 processing | 3 | 9.295378e-03 | 4 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 27 | 1.013562e-02 | 4 |
| REAC | REAC:R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | Signaling by ALK fusions and activated point mutants | 6 | 1.058092e-02 | 4 |
| REAC | REAC:R-HSA-9700206 | Signaling by ALK in cancer | Signaling by ALK in cancer | 6 | 1.058092e-02 | 4 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 33 | 1.146856e-02 | 4 |
| REAC | REAC:R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 5 | 1.221887e-02 | 4 |
| REAC | REAC:R-HSA-170834 | Signaling by TGF-beta Receptor Complex | Signaling by TGF-beta Receptor Complex | 6 | 1.278197e-02 | 4 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 12 | 1.279308e-02 | 4 |
| REAC | REAC:R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | Toll Like Receptor 5 (TLR5) Cascade | 6 | 1.533701e-02 | 4 |
| REAC | REAC:R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | Toll Like Receptor 10 (TLR10) Cascade | 6 | 1.533701e-02 | 4 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 6 | 1.533701e-02 | 4 |
| REAC | REAC:R-HSA-975871 | MyD88 cascade initiated on plasma membrane | MyD88 cascade initiated on plasma membrane | 6 | 1.533701e-02 | 4 |
| REAC | REAC:R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | Transcriptional regulation of brown and beige adipocyte differentiation | 4 | 1.742738e-02 | 4 |
| REAC | REAC:R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4 | 1.742738e-02 | 4 |
| REAC | REAC:R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4 | 1.742738e-02 | 4 |
| REAC | REAC:R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | NFE2L2 regulating tumorigenic genes | 3 | 1.808520e-02 | 4 |
| REAC | REAC:R-HSA-201451 | Signaling by BMP | Signaling by BMP | 4 | 1.990917e-02 | 4 |
| REAC | REAC:R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6 | 2.049423e-02 | 4 |
| REAC | REAC:R-HSA-975155 | MyD88 dependent cascade initiated on endosome | MyD88 dependent cascade initiated on endosome | 6 | 2.167522e-02 | 4 |
| REAC | REAC:R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6 | 2.291008e-02 | 4 |
| REAC | REAC:R-HSA-2559585 | Oncogene Induced Senescence | Oncogene Induced Senescence | 4 | 2.563350e-02 | 4 |
| REAC | REAC:R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | Toll Like Receptor 9 (TLR9) Cascade | 6 | 2.695609e-02 | 4 |
| REAC | REAC:R-HSA-9614085 | FOXO-mediated transcription | FOXO-mediated transcription | 5 | 2.966347e-02 | 4 |
| REAC | REAC:R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4 | 3.634940e-02 | 4 |
| REAC | REAC:R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | Senescence-Associated Secretory Phenotype (SASP) | 6 | 3.675703e-02 | 4 |
| REAC | REAC:R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6 | 3.675703e-02 | 4 |
| REAC | REAC:R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | Toll Like Receptor TLR6:TLR2 Cascade | 6 | 3.675703e-02 | 4 |
| REAC | REAC:R-HSA-9730414 | MITF-M-regulated melanocyte development | MITF-M-regulated melanocyte development | 6 | 3.863562e-02 | 4 |
| REAC | REAC:R-HSA-1989781 | PPARA activates gene expression | PPARA activates gene expression | 6 | 4.058989e-02 | 4 |
| REAC | REAC:R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | Toll Like Receptor 2 (TLR2) Cascade | 6 | 4.262207e-02 | 4 |
| REAC | REAC:R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | Regulation of lipid metabolism by PPARalpha | 6 | 4.262207e-02 | 4 |
| REAC | REAC:R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | Toll Like Receptor TLR1:TLR2 Cascade | 6 | 4.262207e-02 | 4 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 22 | 4.734110e-02 | 4 |
| REAC | REAC:R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 3 | 4.892832e-02 | 4 |
| REAC | REAC:R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | Response of EIF2AK1 (HRI) to heme deficiency | 3 | 4.892832e-02 | 4 |
| REAC | REAC:R-HSA-844456 | The NLRP3 inflammasome | The NLRP3 inflammasome | 3 | 4.892832e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12590_1 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1 | 56 | 0.000335 | 4 |
| TF | TF:M01219 | Factor: SP1:SP3; motif: CCSCCCCCYCC | Factor: SP1:SP3; motif: CCSCCCCCYCC | 56 | 0.000552 | 4 |
| TF | TF:M04953_1 | Factor: Sp1; motif: GGNDGGRGGCGGGG; match class: 1 | Factor: Sp1; motif: GGNDGGRGGCGGGG; match class: 1 | 41 | 0.000599 | 4 |
| TF | TF:M12722_1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | 55 | 0.000675 | 4 |
| TF | TF:M09834 | Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN | Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN | 56 | 0.001188 | 4 |
| TF | TF:M04953 | Factor: Sp1; motif: GGNDGGRGGCGGGG | Factor: Sp1; motif: GGNDGGRGGCGGGG | 64 | 0.001492 | 4 |
| TF | TF:M00695_1 | Factor: ETF; motif: GVGGMGG; match class: 1 | Factor: ETF; motif: GVGGMGG; match class: 1 | 56 | 0.001752 | 4 |
| TF | TF:M10072_1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | 52 | 0.002050 | 4 |
| TF | TF:M12351_1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | 61 | 0.002152 | 4 |
| TF | TF:M00986_1 | Factor: Churchill; motif: CGGGNN; match class: 1 | Factor: Churchill; motif: CGGGNN; match class: 1 | 71 | 0.002407 | 4 |
| TF | TF:M13127 | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS | 78 | 0.002803 | 4 |
| TF | TF:M11401_1 | Factor: Fli-1; motif: NACCGGATATCCGGTN; match class: 1 | Factor: Fli-1; motif: NACCGGATATCCGGTN; match class: 1 | 76 | 0.003082 | 4 |
| TF | TF:M06948 | Factor: Sp2; motif: TGGGCGCGCCCA | Factor: Sp2; motif: TGGGCGCGCCCA | 64 | 0.003677 | 4 |
| TF | TF:M10112 | Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR | Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR | 63 | 0.004643 | 4 |
| TF | TF:M11401 | Factor: Fli-1; motif: NACCGGATATCCGGTN | Factor: Fli-1; motif: NACCGGATATCCGGTN | 76 | 0.006157 | 4 |
| TF | TF:M09826_1 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 | 58 | 0.006223 | 4 |
| TF | TF:M01972 | Factor: EGR-1; motif: TGCGTGGGCGK | Factor: EGR-1; motif: TGCGTGGGCGK | 46 | 0.007258 | 4 |
| TF | TF:M07039_1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | 82 | 0.008639 | 4 |
| TF | TF:M03893_1 | Factor: WT1; motif: GNGGGGGCGGGG; match class: 1 | Factor: WT1; motif: GNGGGGGCGGGG; match class: 1 | 38 | 0.008801 | 4 |
| TF | TF:M00244 | Factor: NGFI-C; motif: WTGCGTGGGYGG | Factor: NGFI-C; motif: WTGCGTGGGYGG | 50 | 0.008943 | 4 |
| TF | TF:M12351 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | 77 | 0.009889 | 4 |
| TF | TF:M01104_1 | Factor: MOVO-B; motif: GNGGGGG; match class: 1 | Factor: MOVO-B; motif: GNGGGGG; match class: 1 | 47 | 0.013266 | 4 |
| TF | TF:M13147 | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN | 72 | 0.014330 | 4 |
| TF | TF:M09636_1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | 83 | 0.019488 | 4 |
| TF | TF:M07486_1 | Factor: ZNF300; motif: SWGGGGGSN; match class: 1 | Factor: ZNF300; motif: SWGGGGGSN; match class: 1 | 55 | 0.028260 | 4 |
| TF | TF:M12160_1 | Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1 | Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1 | 58 | 0.035532 | 4 |
| TF | TF:M12590 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN | 71 | 0.035687 | 4 |
| TF | TF:M03893 | Factor: WT1; motif: GNGGGGGCGGGG | Factor: WT1; motif: GNGGGGGCGGGG | 59 | 0.039637 | 4 |
| TF | TF:M02281 | Factor: SP1; motif: CCCCKCCCCC | Factor: SP1; motif: CCCCKCCCCC | 50 | 0.042298 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2086 | NFKB1-NFKB2-RELA-RELB complex | NFKB1-NFKB2-RELA-RELB complex | 3 | 0.000650 | 4 |
| CORUM | CORUM:2706 | SMAD3-SMAD4-SP1 complex | SMAD3-SMAD4-SP1 complex | 3 | 0.000650 | 4 |
| CORUM | CORUM:2084 | NFKB1-NFKB2-REL-RELA-RELB complex | NFKB1-NFKB2-REL-RELA-RELB complex | 3 | 0.002577 | 4 |
| CORUM | CORUM:3972 | Ubiquitin E3 ligase (SMURF2, SMAD3) - SnoN complex, TGF(beta)-dependent | Ubiquitin E3 ligase (SMURF2, SMAD3) - SnoN complex, TGF(beta)-dependent | 2 | 0.049979 | 4 |
| CORUM | CORUM:3740 | SKI-SMAD3-SMAD4 complex | SKI-SMAD3-SMAD4 complex | 2 | 0.049979 | 4 |
| CORUM | CORUM:3959 | SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent | SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent | 2 | 0.049979 | 4 |
| CORUM | CORUM:2679 | p53-SP1 complex | p53-SP1 complex | 2 | 0.049979 | 4 |
| CORUM | CORUM:2946 | YY1-Notch1-RBP-Jkappa complex | YY1-Notch1-RBP-Jkappa complex | 2 | 0.049979 | 4 |
| CORUM | CORUM:2907 | RBP-Jkappa-Notch1 complex | RBP-Jkappa-Notch1 complex | 2 | 0.049979 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-200b-3p | hsa-mir-200b-3p | hsa-mir-200b-3p | 8 | 0.001905 | 4 |
| MIRNA | MIRNA:hsa-mir-145-5p | hsa-mir-145-5p | hsa-mir-145-5p | 9 | 0.003596 | 4 |
| MIRNA | MIRNA:hsa-mir-200c-3p | hsa-mir-200c-3p | hsa-mir-200c-3p | 8 | 0.007729 | 4 |
| MIRNA | MIRNA:hsa-mir-145-3p | hsa-mir-145-3p | hsa-mir-145-3p | 5 | 0.014023 | 4 |
| MIRNA | MIRNA:hsa-mir-29b-3p | hsa-mir-29b-3p | hsa-mir-29b-3p | 8 | 0.029286 | 4 |
| MIRNA | MIRNA:hsa-mir-6780b-5p | hsa-mir-6780b-5p | hsa-mir-6780b-5p | 7 | 0.032751 | 4 |
| MIRNA | MIRNA:hsa-mir-24-3p | hsa-mir-24-3p | hsa-mir-24-3p | 14 | 0.042312 | 4 |
| MIRNA | MIRNA:hsa-mir-18a-5p | hsa-mir-18a-5p | hsa-mir-18a-5p | 8 | 0.042733 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0010788 | Testicular neoplasm | The presence of a neoplasm of the testis. | 5 | 0.006693 | 4 |
| HP | HP:0100848 | Neoplasm of the male external genitalia | A tumor (abnormal growth of tissue) of the male external genitalia. | 5 | 0.007800 | 4 |
| HP | HP:0001581 | Recurrent skin infections | Infections of the skin that happen multiple times. | 8 | 0.015896 | 4 |
| HP | HP:0010785 | Gonadal neoplasm | A tumor (abnormal growth of tissue) of a gonad. | 7 | 0.018313 | 4 |
| HP | HP:0002088 | Abnormal lung morphology | Any structural anomaly of the lung. | 23 | 0.019671 | 4 |
| HP | HP:0011122 | Abnormality of skin physiology | Any abnormality of the physiological function of the skin. | 15 | 0.028809 | 4 |
| HP | HP:0011123 | Inflammatory abnormality of the skin | The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes. | 14 | 0.029432 | 4 |
| HP | HP:0033151 | Abnormal pharynx morphology | A structural anomaly of the pharynx. | 9 | 0.041033 | 4 |
| HP | HP:0000006 | Autosomal dominant inheritance | A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. | 29 | 0.042869 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 14 | 8.386260e-11 | 5 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 11 | 3.085358e-09 | 5 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 22 | 7.000154e-09 | 5 |
| GO:CC | GO:0030863 | cortical cytoskeleton | "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] | 8 | 9.611634e-09 | 5 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 20 | 3.001856e-08 | 5 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 20 | 3.869229e-08 | 5 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 20 | 3.901833e-08 | 5 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 20 | 3.901833e-08 | 5 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 26 | 4.500388e-08 | 5 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 20 | 2.984991e-07 | 5 |
| GO:CC | GO:0005884 | actin filament | "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] | 7 | 6.016350e-07 | 5 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 13 | 1.237946e-06 | 5 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 22 | 2.044844e-06 | 5 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 30 | 3.666608e-06 | 5 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 30 | 3.680693e-06 | 5 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 9 | 1.535299e-05 | 5 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 9 | 1.870767e-05 | 5 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 26 | 5.035501e-05 | 5 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 17 | 6.204221e-05 | 5 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 38 | 8.516804e-05 | 5 |
| GO:CC | GO:0030864 | cortical actin cytoskeleton | "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] | 5 | 1.134067e-04 | 5 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 17 | 1.264491e-04 | 5 |
| GO:CC | GO:0030426 | growth cone | "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] | 6 | 1.434635e-04 | 5 |
| GO:CC | GO:0030427 | site of polarized growth | "Any part of a cell where non-isotropic growth takes place." [GOC:mah] | 6 | 1.703565e-04 | 5 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 22 | 2.045993e-04 | 5 |
| GO:CC | GO:0097136 | Bcl-2 family protein complex | "A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed." [GOC:so, PMID:14634621] | 3 | 2.195035e-04 | 5 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 13 | 2.457838e-04 | 5 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 12 | 1.773959e-03 | 5 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 22 | 2.145673e-03 | 5 |
| GO:CC | GO:0150034 | distal axon | "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] | 6 | 2.794564e-03 | 5 |
| GO:CC | GO:0098862 | cluster of actin-based cell projections | "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] | 5 | 3.635103e-03 | 5 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 41 | 3.760932e-03 | 5 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 10 | 4.248228e-03 | 5 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 10 | 4.530939e-03 | 5 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 9 | 6.354303e-03 | 5 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 40 | 8.637482e-03 | 5 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 7 | 1.043156e-02 | 5 |
| GO:CC | GO:0005903 | brush border | "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] | 4 | 1.155639e-02 | 5 |
| GO:CC | GO:0002102 | podosome | "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] | 3 | 1.364445e-02 | 5 |
| GO:CC | GO:0072357 | PTW/PP1 phosphatase complex | "A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061] | 2 | 1.593493e-02 | 5 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 8 | 2.556105e-02 | 5 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 14 | 2.776835e-02 | 5 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 14 | 2.848254e-02 | 5 |
| GO:CC | GO:0043005 | neuron projection | "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] | 10 | 3.171892e-02 | 5 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 11 | 3.668037e-02 | 5 |
| GO:CC | GO:0016459 | myosin complex | "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin] | 3 | 3.864142e-02 | 5 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 41 | 4.035744e-02 | 5 |
| GO:CC | GO:0030424 | axon | "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] | 7 | 4.253563e-02 | 5 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 23 | 4.826844e-02 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 12 | 4.287881e-07 | 5 |
| GO:MF | GO:0051015 | actin filament binding | "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 8 | 4.208767e-06 | 5 |
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 10 | 7.480930e-06 | 5 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 9 | 9.842911e-06 | 5 |
| GO:MF | GO:0051434 | BH3 domain binding | "Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] | 3 | 7.064315e-05 | 5 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 17 | 1.569663e-04 | 5 |
| GO:MF | GO:0051400 | BH domain binding | "Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] | 3 | 7.703641e-04 | 5 |
| GO:MF | GO:0070513 | death domain binding | "Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531] | 3 | 1.000027e-03 | 5 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 10 | 1.671720e-03 | 5 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 11 | 1.818409e-03 | 5 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 12 | 4.050944e-03 | 5 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 9 | 5.562141e-03 | 5 |
| GO:MF | GO:0004857 | enzyme inhibitor activity | "Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc] | 7 | 7.427802e-03 | 5 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 8 | 2.191287e-02 | 5 |
| GO:MF | GO:0008289 | lipid binding | "Binding to a lipid." [GOC:ai] | 9 | 2.263056e-02 | 5 |
| GO:MF | GO:0000146 | microfilament motor activity | "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949] | 3 | 2.624301e-02 | 5 |
| GO:MF | GO:0005516 | calmodulin binding | "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] | 5 | 2.910599e-02 | 5 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 41 | 3.067614e-02 | 5 |
| GO:MF | GO:0140678 | molecular function inhibitor activity | "A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators] | 7 | 4.118064e-02 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 13 | 0.000009 | 5 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 23 | 0.000033 | 5 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 23 | 0.000047 | 5 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 12 | 0.000063 | 5 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 15 | 0.000151 | 5 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 21 | 0.000166 | 5 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 11 | 0.000183 | 5 |
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 9 | 0.000377 | 5 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 19 | 0.000440 | 5 |
| GO:BP | GO:0030048 | actin filament-based movement | "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] | 6 | 0.000453 | 5 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 19 | 0.000471 | 5 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 12 | 0.000586 | 5 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 28 | 0.000739 | 5 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 8 | 0.000754 | 5 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 12 | 0.000777 | 5 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 16 | 0.000973 | 5 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 20 | 0.003170 | 5 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 31 | 0.003599 | 5 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 26 | 0.004985 | 5 |
| GO:BP | GO:0061024 | membrane organization | "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] | 10 | 0.005387 | 5 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 25 | 0.006196 | 5 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 31 | 0.006750 | 5 |
| GO:BP | GO:1903921 | regulation of protein processing in phagocytic vesicle | "Any process that modulates the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] | 2 | 0.006870 | 5 |
| GO:BP | GO:1903923 | positive regulation of protein processing in phagocytic vesicle | "Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] | 2 | 0.006870 | 5 |
| GO:BP | GO:1900756 | protein processing in phagocytic vesicle | "Protein processing that takes place in the phagosome. Most protein processing in the phagosome represents protein degradation." [GOC:rjd, GOC:TermGenie] | 2 | 0.006870 | 5 |
| GO:BP | GO:1904780 | negative regulation of protein localization to centrosome | "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] | 2 | 0.006870 | 5 |
| GO:BP | GO:1903729 | regulation of plasma membrane organization | "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900] | 3 | 0.007012 | 5 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 9 | 0.007213 | 5 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 25 | 0.008033 | 5 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] | 6 | 0.009704 | 5 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 14 | 0.010922 | 5 |
| GO:BP | GO:0051293 | establishment of spindle localization | "The directed movement of the spindle to a specific location in the cell." [GOC:ai] | 4 | 0.012627 | 5 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 10 | 0.013026 | 5 |
| GO:BP | GO:0006897 | endocytosis | "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis] | 9 | 0.013202 | 5 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 19 | 0.015478 | 5 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 25 | 0.016102 | 5 |
| GO:BP | GO:0051653 | spindle localization | "Any process in which is the spindle is transported to, and/or maintained in, a specific location." [GOC:ai] | 4 | 0.017143 | 5 |
| GO:BP | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705] | 4 | 0.019247 | 5 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 12 | 0.019573 | 5 |
| GO:BP | GO:0046604 | positive regulation of mitotic centrosome separation | "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai] | 2 | 0.020585 | 5 |
| GO:BP | GO:0038034 | signal transduction in absence of ligand | "The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor." [GOC:al, GOC:ppm, GOC:pr, PMID:15044679] | 4 | 0.021535 | 5 |
| GO:BP | GO:2001236 | regulation of extrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 5 | 0.023583 | 5 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 14 | 0.024747 | 5 |
| GO:BP | GO:0010954 | positive regulation of protein processing | "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] | 3 | 0.025070 | 5 |
| GO:BP | GO:0030010 | establishment of cell polarity | "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] | 5 | 0.025861 | 5 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 14 | 0.027590 | 5 |
| GO:BP | GO:0048284 | organelle fusion | "The creation of a single organelle from two or more organelles." [GOC:jid] | 5 | 0.030929 | 5 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 16 | 0.031144 | 5 |
| GO:BP | GO:1903319 | positive regulation of protein maturation | "Any process that activates or increases the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 3 | 0.032117 | 5 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 10 | 0.033578 | 5 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 36 | 0.035816 | 5 |
| GO:BP | GO:0005977 | glycogen metabolic process | "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] | 4 | 0.039712 | 5 |
| GO:BP | GO:2000295 | regulation of hydrogen peroxide catabolic process | "Any process that modulates the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF] | 2 | 0.041118 | 5 |
| GO:BP | GO:1904019 | epithelial cell apoptotic process | "Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015] | 4 | 0.041615 | 5 |
| GO:BP | GO:0044042 | glucan metabolic process | "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl] | 4 | 0.043583 | 5 |
| GO:BP | GO:0009605 | response to external stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] | 15 | 0.048384 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5627123 | RHO GTPases activate PAKs | RHO GTPases activate PAKs | 4 | 0.000081 | 5 |
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 10 | 0.002435 | 5 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 10 | 0.002940 | 5 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 17 | 0.015875 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3872 | Apoptosis regulation by parathyroid hormone related protein | Apoptosis regulation by parathyroid hormone related protein | 4 | 0.000216 | 5 |
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 6 | 0.000386 | 5 |
| WP | WP:WP4659 | Gastrin signaling | Gastrin signaling | 5 | 0.007590 | 5 |
| WP | WP:WP4864 | Host pathogen interaction of human coronaviruses apoptosis | Host pathogen interaction of human coronaviruses apoptosis | 3 | 0.008209 | 5 |
| WP | WP:WP3614 | Photodynamic therapy induced HIF 1 survival signaling | Photodynamic therapy induced HIF 1 survival signaling | 3 | 0.046088 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 10 | 0.001991 | 5 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 7 | 0.009916 | 5 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 10 | 0.039366 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 6 | 0.002814 | 5 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 5 | 0.025700 | 5 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 5 | 0.049092 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6823 | CP–LF–MPO complex | CP–LF–MPO complex | 2 | 0.000132 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097013 | phagocytic vesicle lumen | "The volume enclosed by the membrane of a phagocytic vesicle." [GOC:rs] | 2 | 0.000483 | 6 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 8 | 0.001552 | 6 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 8 | 0.001724 | 6 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 8 | 0.001730 | 6 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 8 | 0.001730 | 6 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 9 | 0.004742 | 6 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 4 | 0.005155 | 6 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 4 | 0.005474 | 6 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 4 | 0.005539 | 6 |
| GO:CC | GO:0071682 | endocytic vesicle lumen | "The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde] | 2 | 0.012130 | 6 |
| GO:CC | GO:0045335 | phagocytic vesicle | "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732] | 3 | 0.012866 | 6 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 5 | 0.021793 | 6 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 9 | 0.036140 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6803157 | Antimicrobial peptides | Antimicrobial peptides | 4 | 0.000769 | 6 |
| REAC | REAC:R-HSA-6799990 | Metal sequestration by antimicrobial proteins | Metal sequestration by antimicrobial proteins | 2 | 0.004914 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0042742 | defense response to bacterium | "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] | 5 | 0.000883 | 6 |
| GO:BP | GO:0098542 | defense response to other organism | "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] | 7 | 0.002157 | 6 |
| GO:BP | GO:0050832 | defense response to fungus | "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] | 3 | 0.005814 | 6 |
| GO:BP | GO:0009620 | response to fungus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] | 3 | 0.009755 | 6 |
| GO:BP | GO:0051707 | response to other organism | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] | 7 | 0.010180 | 6 |
| GO:BP | GO:0043207 | response to external biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] | 7 | 0.010308 | 6 |
| GO:BP | GO:0009607 | response to biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] | 7 | 0.012106 | 6 |
| GO:BP | GO:0140546 | defense response to symbiont | "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] | 6 | 0.016597 | 6 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 7 | 0.019743 | 6 |
| GO:BP | GO:0006952 | defense response | "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] | 7 | 0.027849 | 6 |
| GO:BP | GO:0050829 | defense response to Gram-negative bacterium | "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] | 3 | 0.028539 | 6 |
| GO:BP | GO:0009617 | response to bacterium | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] | 5 | 0.040695 | 6 |
| GO:BP | GO:0002376 | immune system process | "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] | 8 | 0.045443 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04970 | Salivary secretion | Salivary secretion | 3 | 0.001966 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471402 | Skin 2; cells in corneal layer[≥Medium] | Skin 2; cells in corneal layer[≥Medium] | 3 | 0.010672 | 6 |
| HPA | HPA:0471401 | Skin 2; cells in corneal layer[≥Low] | Skin 2; cells in corneal layer[≥Low] | 3 | 0.037919 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 26 | 6.327945e-25 | 0 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 26 | 2.835511e-24 | 0 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 48 | 7.820793e-24 | 0 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 26 | 1.730138e-16 | 0 |
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 10 | 1.436031e-14 | 0 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 42 | 1.505980e-11 | 0 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 27 | 5.303605e-11 | 0 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 10 | 8.349797e-11 | 0 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 54 | 8.421250e-11 | 0 |
| GO:MF | GO:0097718 | disordered domain specific binding | "Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698] | 8 | 1.053280e-10 | 0 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 17 | 1.252183e-10 | 0 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 24 | 7.491329e-10 | 0 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 33 | 2.143695e-09 | 0 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 15 | 2.636238e-09 | 0 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 20 | 1.974014e-08 | 0 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 82 | 1.988314e-08 | 0 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 19 | 2.690100e-08 | 0 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 10 | 3.321830e-08 | 0 |
| GO:MF | GO:0042826 | histone deacetylase binding | "Binding to histone deacetylase." [GOC:jl] | 10 | 4.959231e-08 | 0 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 24 | 1.109096e-07 | 0 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 30 | 6.116756e-07 | 0 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 16 | 9.959304e-07 | 0 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 25 | 2.072283e-06 | 0 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 16 | 2.340972e-06 | 0 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 28 | 2.626671e-06 | 0 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 31 | 2.792355e-06 | 0 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 30 | 3.304576e-06 | 0 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 15 | 3.608332e-06 | 0 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 30 | 3.935729e-06 | 0 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 28 | 4.923230e-06 | 0 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 28 | 5.857951e-06 | 0 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 8 | 9.552510e-06 | 0 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 23 | 1.007218e-05 | 0 |
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 8 | 1.024006e-05 | 0 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 31 | 1.035869e-05 | 0 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 30 | 1.372094e-05 | 0 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 15 | 1.443878e-05 | 0 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 23 | 1.673388e-05 | 0 |
| GO:MF | GO:0031072 | heat shock protein binding | "Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw] | 8 | 3.045302e-05 | 0 |
| GO:MF | GO:0003712 | transcription coregulator activity | "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] | 13 | 4.289721e-05 | 0 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 12 | 4.948217e-05 | 0 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 28 | 1.753366e-04 | 0 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 49 | 1.764681e-04 | 0 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 48 | 1.971447e-04 | 0 |
| GO:MF | GO:0042162 | telomeric DNA binding | "Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624] | 5 | 2.243939e-04 | 0 |
| GO:MF | GO:0003725 | double-stranded RNA binding | "Binding to double-stranded RNA." [GOC:jl] | 6 | 2.590590e-04 | 0 |
| GO:MF | GO:0043021 | ribonucleoprotein complex binding | "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] | 8 | 2.708827e-04 | 0 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 12 | 3.107865e-04 | 0 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 18 | 5.855522e-04 | 0 |
| GO:MF | GO:0019903 | protein phosphatase binding | "Binding to a protein phosphatase." [GOC:jl] | 7 | 1.045814e-03 | 0 |
| GO:MF | GO:0030235 | nitric-oxide synthase regulator activity | "Binds to and modulates the activity of nitric oxide synthase." [GOC:mah] | 3 | 1.141855e-03 | 0 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 18 | 1.173529e-03 | 0 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 18 | 1.186773e-03 | 0 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 18 | 1.186773e-03 | 0 |
| GO:MF | GO:0140296 | general transcription initiation factor binding | "Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation." [GOC:txnOH-2018] | 5 | 1.223345e-03 | 0 |
| GO:MF | GO:0023026 | MHC class II protein complex binding | "Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw] | 4 | 1.286948e-03 | 0 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 28 | 1.860031e-03 | 0 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 20 | 3.724154e-03 | 0 |
| GO:MF | GO:0098505 | G-rich strand telomeric DNA binding | "Binding to G-rich, single-stranded, telomere-associated DNA." [PMID:11349150] | 3 | 3.880682e-03 | 0 |
| GO:MF | GO:0004517 | nitric-oxide synthase activity | "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, RHEA:19897] | 3 | 3.880682e-03 | 0 |
| GO:MF | GO:0001221 | transcription coregulator binding | "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] | 6 | 4.338930e-03 | 0 |
| GO:MF | GO:0002039 | p53 binding | "Binding to one of the p53 family of proteins." [GOC:hjd] | 5 | 4.554306e-03 | 0 |
| GO:MF | GO:0023023 | MHC protein complex binding | "Binding to a major histocompatibility complex." [GOC:mtg_signal, GOC:vw] | 4 | 4.820420e-03 | 0 |
| GO:MF | GO:0140666 | annealing activity | "An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule." [PMID:22888405] | 3 | 5.320338e-03 | 0 |
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 9 | 5.919028e-03 | 0 |
| GO:MF | GO:0019902 | phosphatase binding | "Binding to a phosphatase." [GOC:jl] | 7 | 6.425415e-03 | 0 |
| GO:MF | GO:0043047 | single-stranded telomeric DNA binding | "Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] | 3 | 7.073046e-03 | 0 |
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 5 | 7.322753e-03 | 0 |
| GO:MF | GO:0051087 | protein-folding chaperone binding | "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443] | 6 | 8.978066e-03 | 0 |
| GO:MF | GO:0098847 | sequence-specific single stranded DNA binding | "Binding to single-stranded DNA of a specific nucleotide composition." [PMID:9531483] | 3 | 1.163437e-02 | 0 |
| GO:MF | GO:0048156 | tau protein binding | "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] | 4 | 1.409714e-02 | 0 |
| GO:MF | GO:0140693 | molecular condensate scaffold activity | "Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate." [PMID:28225081] | 4 | 1.691532e-02 | 0 |
| GO:MF | GO:0051787 | misfolded protein binding | "Binding to a misfolded protein." [GOC:ai] | 3 | 1.779460e-02 | 0 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 15 | 2.101948e-02 | 0 |
| GO:MF | GO:1990381 | ubiquitin-specific protease binding | "Binding to a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750] | 3 | 2.577803e-02 | 0 |
| GO:MF | GO:0061980 | regulatory RNA binding | "Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme." [PMID:14622403, PMID:23475961] | 4 | 2.785231e-02 | 0 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 45 | 3.212616e-02 | 0 |
| GO:MF | GO:0043531 | ADP binding | "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] | 4 | 3.243642e-02 | 0 |
| GO:MF | GO:0140677 | molecular function activator activity | "A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators] | 15 | 3.480235e-02 | 0 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 12 | 3.793050e-02 | 0 |
| GO:MF | GO:0003713 | transcription coactivator activity | "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 7 | 3.865679e-02 | 0 |
| GO:MF | GO:0008013 | beta-catenin binding | "Binding to a catenin beta subunit." [GOC:bf] | 5 | 3.993190e-02 | 0 |
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 20 | 4.039114e-02 | 0 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 10 | 4.270330e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 58 | 6.711511e-24 | 0 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 66 | 1.549214e-22 | 0 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 44 | 3.064227e-22 | 0 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 54 | 1.159623e-21 | 0 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 50 | 1.300373e-21 | 0 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 43 | 2.188366e-21 | 0 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 68 | 1.081911e-19 | 0 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 47 | 2.711999e-19 | 0 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 69 | 1.502444e-18 | 0 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 18 | 2.630947e-18 | 0 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 49 | 2.705853e-18 | 0 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 47 | 3.069273e-18 | 0 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 37 | 4.074418e-18 | 0 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 41 | 6.454132e-18 | 0 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 41 | 6.957663e-18 | 0 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 32 | 7.090912e-18 | 0 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 32 | 7.298696e-18 | 0 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 30 | 8.395773e-18 | 0 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 47 | 8.651371e-18 | 0 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 49 | 1.554824e-17 | 0 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 63 | 1.592878e-17 | 0 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 36 | 1.670530e-17 | 0 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 40 | 1.928028e-17 | 0 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 30 | 2.253375e-17 | 0 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 35 | 3.299443e-17 | 0 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 40 | 3.385214e-17 | 0 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 18 | 4.358446e-17 | 0 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 63 | 4.644282e-17 | 0 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 35 | 6.578586e-17 | 0 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 22 | 6.923647e-17 | 0 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 53 | 7.613461e-17 | 0 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 53 | 1.296847e-16 | 0 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 64 | 1.298148e-16 | 0 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 61 | 2.456806e-16 | 0 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 49 | 2.863910e-16 | 0 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 34 | 4.782996e-16 | 0 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 32 | 6.957049e-16 | 0 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 35 | 7.536886e-16 | 0 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 56 | 8.071930e-16 | 0 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 52 | 9.955821e-16 | 0 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 49 | 1.051945e-15 | 0 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 49 | 1.161592e-15 | 0 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 39 | 1.389701e-15 | 0 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 60 | 1.721055e-15 | 0 |
| GO:BP | GO:0030162 | regulation of proteolysis | "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] | 21 | 5.658055e-15 | 0 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 24 | 6.835919e-15 | 0 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 60 | 1.131108e-14 | 0 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 42 | 2.794753e-14 | 0 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 44 | 3.976509e-14 | 0 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 58 | 4.050434e-14 | 0 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 24 | 5.106438e-14 | 0 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 30 | 7.152576e-14 | 0 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 40 | 8.735082e-14 | 0 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 31 | 9.515398e-14 | 0 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 32 | 9.661759e-14 | 0 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 32 | 9.858141e-14 | 0 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 65 | 1.797209e-13 | 0 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 47 | 2.213391e-13 | 0 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 15 | 4.161680e-13 | 0 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 26 | 5.322169e-13 | 0 |
| GO:BP | GO:0080135 | regulation of cellular response to stress | "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 21 | 8.057374e-13 | 0 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 70 | 8.265503e-13 | 0 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 72 | 8.727397e-13 | 0 |
| GO:BP | GO:2001234 | negative regulation of apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 16 | 1.021162e-12 | 0 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 18 | 1.021224e-12 | 0 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 33 | 1.095436e-12 | 0 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 41 | 1.170330e-12 | 0 |
| GO:BP | GO:1903050 | regulation of proteolysis involved in protein catabolic process | "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 16 | 1.338934e-12 | 0 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 41 | 1.363844e-12 | 0 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 78 | 1.738766e-12 | 0 |
| GO:BP | GO:0061136 | regulation of proteasomal protein catabolic process | "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] | 15 | 2.082079e-12 | 0 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 29 | 3.098305e-12 | 0 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 46 | 3.998776e-12 | 0 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 29 | 4.282506e-12 | 0 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 18 | 5.510142e-12 | 0 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 17 | 5.787654e-12 | 0 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 26 | 6.140761e-12 | 0 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 43 | 6.603010e-12 | 0 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 14 | 6.763242e-12 | 0 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 26 | 7.408448e-12 | 0 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 37 | 7.925686e-12 | 0 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 26 | 1.097821e-11 | 0 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 33 | 1.426331e-11 | 0 |
| GO:BP | GO:0009628 | response to abiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] | 27 | 1.465686e-11 | 0 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 45 | 1.874360e-11 | 0 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 69 | 2.918350e-11 | 0 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 15 | 3.680558e-11 | 0 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 15 | 4.993607e-11 | 0 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 40 | 6.480911e-11 | 0 |
| GO:BP | GO:0010629 | negative regulation of gene expression | "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 31 | 6.565752e-11 | 0 |
| GO:BP | GO:0035966 | response to topologically incorrect protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] | 13 | 6.571303e-11 | 0 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 20 | 7.597073e-11 | 0 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 62 | 8.194221e-11 | 0 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 64 | 1.046210e-10 | 0 |
| GO:BP | GO:0034605 | cellular response to heat | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] | 10 | 1.222701e-10 | 0 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 16 | 1.423743e-10 | 0 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 77 | 1.465317e-10 | 0 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 29 | 1.529601e-10 | 0 |
| GO:BP | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] | 12 | 1.832790e-10 | 0 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] | 14 | 2.155352e-10 | 0 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 22 | 2.750398e-10 | 0 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 42 | 2.792157e-10 | 0 |
| GO:BP | GO:1901698 | response to nitrogen compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 25 | 2.952148e-10 | 0 |
| GO:BP | GO:0009408 | response to heat | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] | 11 | 3.297901e-10 | 0 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 19 | 3.387478e-10 | 0 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 42 | 3.390290e-10 | 0 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 20 | 4.053227e-10 | 0 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 10 | 4.140517e-10 | 0 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 20 | 5.430080e-10 | 0 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 72 | 5.521906e-10 | 0 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 30 | 6.112130e-10 | 0 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 20 | 6.273036e-10 | 0 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 30 | 6.301857e-10 | 0 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 11 | 1.052791e-09 | 0 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 28 | 1.071295e-09 | 0 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 23 | 1.076108e-09 | 0 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 42 | 1.131382e-09 | 0 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 44 | 1.197497e-09 | 0 |
| GO:BP | GO:0007005 | mitochondrion organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] | 17 | 1.304710e-09 | 0 |
| GO:BP | GO:0010821 | regulation of mitochondrion organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] | 11 | 1.414359e-09 | 0 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 20 | 1.620618e-09 | 0 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 32 | 1.628682e-09 | 0 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 75 | 1.662533e-09 | 0 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 33 | 2.214557e-09 | 0 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 20 | 3.068269e-09 | 0 |
| GO:BP | GO:0009266 | response to temperature stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] | 12 | 4.602667e-09 | 0 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] | 25 | 4.648092e-09 | 0 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 22 | 4.875705e-09 | 0 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 23 | 6.935265e-09 | 0 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 16 | 7.992640e-09 | 0 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 26 | 9.598409e-09 | 0 |
| GO:BP | GO:0045727 | positive regulation of translation | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] | 11 | 1.065637e-08 | 0 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 23 | 1.068208e-08 | 0 |
| GO:BP | GO:0007165 | signal transduction | "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] | 53 | 1.148579e-08 | 0 |
| GO:BP | GO:0006986 | response to unfolded protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] | 11 | 1.248214e-08 | 0 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 75 | 1.444566e-08 | 0 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 15 | 1.450659e-08 | 0 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 79 | 1.639728e-08 | 0 |
| GO:BP | GO:0010647 | positive regulation of cell communication | "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 29 | 1.647204e-08 | 0 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 24 | 1.658747e-08 | 0 |
| GO:BP | GO:0023056 | positive regulation of signaling | "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 29 | 1.669903e-08 | 0 |
| GO:BP | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 10 | 1.742014e-08 | 0 |
| GO:BP | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 10 | 1.742014e-08 | 0 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 28 | 1.765319e-08 | 0 |
| GO:BP | GO:1901796 | regulation of signal transduction by p53 class mediator | "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 10 | 1.917557e-08 | 0 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] | 22 | 1.971076e-08 | 0 |
| GO:BP | GO:0006886 | intracellular protein transport | "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] | 19 | 2.039769e-08 | 0 |
| GO:BP | GO:0048511 | rhythmic process | "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] | 14 | 2.067625e-08 | 0 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 12 | 2.627819e-08 | 0 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 14 | 2.800854e-08 | 0 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 15 | 3.003159e-08 | 0 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] | 27 | 3.010718e-08 | 0 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 17 | 3.914587e-08 | 0 |
| GO:BP | GO:0042752 | regulation of circadian rhythm | "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] | 10 | 3.997318e-08 | 0 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 62 | 4.047805e-08 | 0 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 17 | 4.791391e-08 | 0 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 33 | 5.106184e-08 | 0 |
| GO:BP | GO:0007623 | circadian rhythm | "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] | 12 | 5.556135e-08 | 0 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 61 | 5.670261e-08 | 0 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 23 | 6.600003e-08 | 0 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 14 | 6.940865e-08 | 0 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 14 | 6.940865e-08 | 0 |
| GO:BP | GO:1904356 | regulation of telomere maintenance via telomere lengthening | "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 8 | 7.158489e-08 | 0 |
| GO:BP | GO:0034097 | response to cytokine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] | 21 | 8.912864e-08 | 0 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 27 | 1.001443e-07 | 0 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 54 | 1.026681e-07 | 0 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] | 20 | 1.058206e-07 | 0 |
| GO:BP | GO:0071345 | cellular response to cytokine stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah] | 20 | 1.080488e-07 | 0 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 35 | 1.125674e-07 | 0 |
| GO:BP | GO:1901652 | response to peptide | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] | 21 | 1.192366e-07 | 0 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 75 | 1.257523e-07 | 0 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 16 | 1.335979e-07 | 0 |
| GO:BP | GO:0016032 | viral process | "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah] | 15 | 1.357253e-07 | 0 |
| GO:BP | GO:0006109 | regulation of carbohydrate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] | 11 | 1.417128e-07 | 0 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 8 | 1.481219e-07 | 0 |
| GO:BP | GO:0045595 | regulation of cell differentiation | "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] | 26 | 1.814583e-07 | 0 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 33 | 1.864246e-07 | 0 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 8 | 2.221363e-07 | 0 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 51 | 2.300981e-07 | 0 |
| GO:BP | GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 10 | 2.332902e-07 | 0 |
| GO:BP | GO:0043255 | regulation of carbohydrate biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl] | 9 | 2.340102e-07 | 0 |
| GO:BP | GO:0006006 | glucose metabolic process | "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] | 11 | 2.431862e-07 | 0 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 29 | 2.563909e-07 | 0 |
| GO:BP | GO:0033044 | regulation of chromosome organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] | 12 | 2.885361e-07 | 0 |
| GO:BP | GO:0002218 | activation of innate immune response | "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805] | 13 | 3.029289e-07 | 0 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 20 | 3.136372e-07 | 0 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 53 | 3.521479e-07 | 0 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 27 | 3.567582e-07 | 0 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 16 | 3.612524e-07 | 0 |
| GO:BP | GO:0034599 | cellular response to oxidative stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] | 12 | 3.652789e-07 | 0 |
| GO:BP | GO:0016051 | carbohydrate biosynthetic process | "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 11 | 3.838933e-07 | 0 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488] | 13 | 3.851442e-07 | 0 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 23 | 3.940023e-07 | 0 |
| GO:BP | GO:1903312 | negative regulation of mRNA metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 9 | 4.057956e-07 | 0 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 53 | 4.120516e-07 | 0 |
| GO:BP | GO:0070848 | response to growth factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah] | 18 | 4.208569e-07 | 0 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 28 | 4.305683e-07 | 0 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 18 | 4.809323e-07 | 0 |
| GO:BP | GO:0062197 | cellular response to chemical stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] | 13 | 4.872127e-07 | 0 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] | 12 | 5.270954e-07 | 0 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] | 17 | 5.352319e-07 | 0 |
| GO:BP | GO:0062012 | regulation of small molecule metabolic process | "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] | 13 | 5.469808e-07 | 0 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 17 | 6.326636e-07 | 0 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 35 | 6.513149e-07 | 0 |
| GO:BP | GO:0051131 | chaperone-mediated protein complex assembly | "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai] | 6 | 6.894349e-07 | 0 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 33 | 7.095627e-07 | 0 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] | 13 | 8.277404e-07 | 0 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 48 | 9.295924e-07 | 0 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 12 | 1.014627e-06 | 0 |
| GO:BP | GO:1901800 | positive regulation of proteasomal protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] | 9 | 1.022359e-06 | 0 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 21 | 1.115227e-06 | 0 |
| GO:BP | GO:0006458 | 'de novo' protein folding | "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] | 7 | 1.252996e-06 | 0 |
| GO:BP | GO:0045087 | innate immune response | "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] | 20 | 1.304385e-06 | 0 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 10 | 1.475994e-06 | 0 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 21 | 1.500588e-06 | 0 |
| GO:BP | GO:0042026 | protein refolding | "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] | 6 | 1.502376e-06 | 0 |
| GO:BP | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] | 8 | 1.577472e-06 | 0 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 21 | 1.709026e-06 | 0 |
| GO:BP | GO:0006914 | autophagy | "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464] | 16 | 1.778473e-06 | 0 |
| GO:BP | GO:0061919 | process utilizing autophagic mechanism | "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] | 16 | 1.778473e-06 | 0 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 20 | 2.084817e-06 | 0 |
| GO:BP | GO:0019318 | hexose metabolic process | "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] | 11 | 2.173277e-06 | 0 |
| GO:BP | GO:0045088 | regulation of innate immune response | "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] | 14 | 3.318016e-06 | 0 |
| GO:BP | GO:0045089 | positive regulation of innate immune response | "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] | 13 | 3.654099e-06 | 0 |
| GO:BP | GO:0016055 | Wnt signaling pathway | "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397] | 14 | 4.280613e-06 | 0 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 19 | 5.492963e-06 | 0 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 19 | 5.587950e-06 | 0 |
| GO:BP | GO:0005996 | monosaccharide metabolic process | "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732] | 11 | 6.276101e-06 | 0 |
| GO:BP | GO:2000767 | positive regulation of cytoplasmic translation | "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 5 | 6.325746e-06 | 0 |
| GO:BP | GO:0002253 | activation of immune response | "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] | 15 | 6.443166e-06 | 0 |
| GO:BP | GO:0005975 | carbohydrate metabolic process | "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] | 15 | 6.600336e-06 | 0 |
| GO:BP | GO:0140546 | defense response to symbiont | "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] | 20 | 6.685832e-06 | 0 |
| GO:BP | GO:0010906 | regulation of glucose metabolic process | "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] | 8 | 6.867614e-06 | 0 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 52 | 7.091965e-06 | 0 |
| GO:BP | GO:0048869 | cellular developmental process | "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] | 41 | 7.977155e-06 | 0 |
| GO:BP | GO:0002833 | positive regulation of response to biotic stimulus | "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] | 13 | 8.201837e-06 | 0 |
| GO:BP | GO:0006979 | response to oxidative stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] | 13 | 8.201837e-06 | 0 |
| GO:BP | GO:0051094 | positive regulation of developmental process | "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 22 | 8.562441e-06 | 0 |
| GO:BP | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 8 | 8.784868e-06 | 0 |
| GO:BP | GO:0016567 | protein ubiquitination | "The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419] | 17 | 8.851018e-06 | 0 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 18 | 9.750318e-06 | 0 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 9 | 9.988420e-06 | 0 |
| GO:BP | GO:0045861 | negative regulation of proteolysis | "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] | 9 | 1.060699e-05 | 0 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 23 | 1.159648e-05 | 0 |
| GO:BP | GO:0009607 | response to biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] | 24 | 1.204255e-05 | 0 |
| GO:BP | GO:0008637 | apoptotic mitochondrial changes | "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis] | 8 | 1.205033e-05 | 0 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah] | 16 | 1.376597e-05 | 0 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 42 | 1.470794e-05 | 0 |
| GO:BP | GO:0031349 | positive regulation of defense response | "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah] | 14 | 1.523444e-05 | 0 |
| GO:BP | GO:0045732 | positive regulation of protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] | 10 | 1.543104e-05 | 0 |
| GO:BP | GO:2001236 | regulation of extrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 9 | 1.787084e-05 | 0 |
| GO:BP | GO:0009605 | response to external stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] | 29 | 1.865826e-05 | 0 |
| GO:BP | GO:0035967 | cellular response to topologically incorrect protein | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] | 8 | 1.890063e-05 | 0 |
| GO:BP | GO:0031347 | regulation of defense response | "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] | 17 | 1.915201e-05 | 0 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 12 | 2.017976e-05 | 0 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 10 | 2.411961e-05 | 0 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 7 | 2.826490e-05 | 0 |
| GO:BP | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] | 6 | 2.946317e-05 | 0 |
| GO:BP | GO:0051084 | 'de novo' post-translational protein folding | "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] | 6 | 2.946317e-05 | 0 |
| GO:BP | GO:0030154 | cell differentiation | "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] | 40 | 3.031079e-05 | 0 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 11 | 3.035605e-05 | 0 |
| GO:BP | GO:0002831 | regulation of response to biotic stimulus | "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] | 14 | 3.455811e-05 | 0 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 52 | 3.625390e-05 | 0 |
| GO:BP | GO:0032501 | multicellular organismal process | "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] | 53 | 3.740664e-05 | 0 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 9 | 4.187415e-05 | 0 |
| GO:BP | GO:0030522 | intracellular receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a receptor located within a cell." [GOC:bf, GOC:mah] | 12 | 4.312927e-05 | 0 |
| GO:BP | GO:0032210 | regulation of telomere maintenance via telomerase | "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 6 | 4.485461e-05 | 0 |
| GO:BP | GO:0001649 | osteoblast differentiation | "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid] | 10 | 4.527559e-05 | 0 |
| GO:BP | GO:0002753 | cytoplasmic pattern recognition receptor signaling pathway | "The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967, PMID:17328678, PMID:18272355, PMID:19531363, PMID:21187438] | 9 | 4.629423e-05 | 0 |
| GO:BP | GO:0044092 | negative regulation of molecular function | "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 14 | 4.654161e-05 | 0 |
| GO:BP | GO:0006839 | mitochondrial transport | "Transport of substances into, out of or within a mitochondrion." [GOC:ai] | 9 | 5.637370e-05 | 0 |
| GO:BP | GO:0019058 | viral life cycle | "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272] | 11 | 5.809860e-05 | 0 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] | 11 | 6.841826e-05 | 0 |
| GO:BP | GO:0006325 | chromatin organization | "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] | 17 | 7.021543e-05 | 0 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 15 | 7.036663e-05 | 0 |
| GO:BP | GO:0045184 | establishment of protein localization | "The directed movement of a protein to a specific location." [GOC:bf] | 25 | 7.064688e-05 | 0 |
| GO:BP | GO:0070841 | inclusion body assembly | "The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah] | 5 | 7.488298e-05 | 0 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 28 | 7.501565e-05 | 0 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 28 | 7.706403e-05 | 0 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 17 | 8.002628e-05 | 0 |
| GO:BP | GO:0016049 | cell growth | "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] | 13 | 8.025839e-05 | 0 |
| GO:BP | GO:0019079 | viral genome replication | "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534] | 8 | 8.039787e-05 | 0 |
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 9 | 8.632625e-05 | 0 |
| GO:BP | GO:0098542 | defense response to other organism | "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] | 20 | 8.956161e-05 | 0 |
| GO:BP | GO:0009205 | purine ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 9.459605e-05 | 0 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 13 | 9.487169e-05 | 0 |
| GO:BP | GO:0010332 | response to gamma radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators] | 6 | 9.571668e-05 | 0 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | "The alteration of an amino acid residue in a peptide." [GOC:mah] | 15 | 9.589299e-05 | 0 |
| GO:BP | GO:0045912 | negative regulation of carbohydrate metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] | 6 | 1.076061e-04 | 0 |
| GO:BP | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 5 | 1.130993e-04 | 0 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] | 31 | 1.138316e-04 | 0 |
| GO:BP | GO:0009144 | purine nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 1.222209e-04 | 0 |
| GO:BP | GO:0009199 | ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 1.222209e-04 | 0 |
| GO:BP | GO:0006402 | mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 10 | 1.266983e-04 | 0 |
| GO:BP | GO:0070934 | CRD-mediated mRNA stabilization | "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] | 4 | 1.321353e-04 | 0 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] | 12 | 1.444134e-04 | 0 |
| GO:BP | GO:0033993 | response to lipid | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] | 17 | 1.461900e-04 | 0 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 50 | 1.510195e-04 | 0 |
| GO:BP | GO:0002221 | pattern recognition receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] | 10 | 1.567308e-04 | 0 |
| GO:BP | GO:0015031 | protein transport | "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 21 | 1.635877e-04 | 0 |
| GO:BP | GO:0071396 | cellular response to lipid | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] | 14 | 1.668210e-04 | 0 |
| GO:BP | GO:0030177 | positive regulation of Wnt signaling pathway | "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] | 8 | 1.679615e-04 | 0 |
| GO:BP | GO:0051707 | response to other organism | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] | 22 | 1.824115e-04 | 0 |
| GO:BP | GO:0032006 | regulation of TOR signaling | "Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah] | 8 | 1.869151e-04 | 0 |
| GO:BP | GO:0043207 | response to external biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] | 22 | 1.885493e-04 | 0 |
| GO:BP | GO:0031400 | negative regulation of protein modification process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 11 | 1.936096e-04 | 0 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 14 | 1.956083e-04 | 0 |
| GO:BP | GO:0034614 | cellular response to reactive oxygen species | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] | 8 | 1.970623e-04 | 0 |
| GO:BP | GO:1900152 | negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] | 4 | 1.976225e-04 | 0 |
| GO:BP | GO:0010038 | response to metal ion | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] | 11 | 2.050920e-04 | 0 |
| GO:BP | GO:0009141 | nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 2.135518e-04 | 0 |
| GO:BP | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:ai, GOC:mtg_apoptosis] | 6 | 2.296869e-04 | 0 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] | 18 | 2.332915e-04 | 0 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 30 | 2.349997e-04 | 0 |
| GO:BP | GO:0051085 | chaperone cofactor-dependent protein refolding | "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb] | 5 | 2.351854e-04 | 0 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] | 29 | 2.493879e-04 | 0 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] | 18 | 2.533755e-04 | 0 |
| GO:BP | GO:0071705 | nitrogen compound transport | "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] | 24 | 2.734762e-04 | 0 |
| GO:BP | GO:1902253 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871] | 5 | 2.778994e-04 | 0 |
| GO:BP | GO:0002758 | innate immune response-activating signaling pathway | "The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an innate immune response." [GOC:jy, GOC:mah, PMID:11418339, PMID:28105028] | 10 | 2.785503e-04 | 0 |
| GO:BP | GO:0032103 | positive regulation of response to external stimulus | "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] | 14 | 2.937805e-04 | 0 |
| GO:BP | GO:0010506 | regulation of autophagy | "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] | 11 | 3.210121e-04 | 0 |
| GO:BP | GO:0010586 | miRNA metabolic process | "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] | 7 | 3.468043e-04 | 0 |
| GO:BP | GO:0050778 | positive regulation of immune response | "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 15 | 3.620410e-04 | 0 |
| GO:BP | GO:0090263 | positive regulation of canonical Wnt signaling pathway | "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] | 7 | 3.699385e-04 | 0 |
| GO:BP | GO:0062014 | negative regulation of small molecule metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] | 7 | 3.699385e-04 | 0 |
| GO:BP | GO:0043086 | negative regulation of catalytic activity | "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] | 10 | 3.719473e-04 | 0 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 6 | 3.732017e-04 | 0 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 9 | 4.039130e-04 | 0 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 36 | 4.076830e-04 | 0 |
| GO:BP | GO:0072594 | establishment of protein localization to organelle | "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] | 14 | 4.188765e-04 | 0 |
| GO:BP | GO:0046034 | ATP metabolic process | "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] | 9 | 4.868759e-04 | 0 |
| GO:BP | GO:0006606 | protein import into nucleus | "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] | 8 | 5.025623e-04 | 0 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] | 9 | 5.051377e-04 | 0 |
| GO:BP | GO:0048024 | regulation of mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 7 | 5.061022e-04 | 0 |
| GO:BP | GO:0032885 | regulation of polysaccharide biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah] | 5 | 5.140168e-04 | 0 |
| GO:BP | GO:0031929 | TOR signaling | "The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295] | 8 | 5.262183e-04 | 0 |
| GO:BP | GO:0048255 | mRNA stabilization | "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid] | 6 | 5.350492e-04 | 0 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 19 | 5.705166e-04 | 0 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 29 | 5.718558e-04 | 0 |
| GO:BP | GO:2000765 | regulation of cytoplasmic translation | "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 5 | 5.925438e-04 | 0 |
| GO:BP | GO:0006952 | defense response | "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] | 23 | 5.978602e-04 | 0 |
| GO:BP | GO:0051170 | import into nucleus | "The directed movement of substances into the nucleus." [GOC:ai] | 8 | 6.306454e-04 | 0 |
| GO:BP | GO:0007006 | mitochondrial membrane organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 7 | 6.434024e-04 | 0 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] | 8 | 7.201836e-04 | 0 |
| GO:BP | GO:0006401 | RNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 10 | 7.246742e-04 | 0 |
| GO:BP | GO:0002682 | regulation of immune system process | "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] | 21 | 7.475656e-04 | 0 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 24 | 7.602411e-04 | 0 |
| GO:BP | GO:0039531 | regulation of cytoplasmic pattern recognition receptor signaling pathway | "Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway." [GOC:bf, GOC:jl] | 7 | 7.658573e-04 | 0 |
| GO:BP | GO:0051093 | negative regulation of developmental process | "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 16 | 7.910935e-04 | 0 |
| GO:BP | GO:0002757 | immune response-activating signaling pathway | "The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add] | 12 | 8.051997e-04 | 0 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 10 | 8.135208e-04 | 0 |
| GO:BP | GO:0002376 | immune system process | "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] | 29 | 8.456806e-04 | 0 |
| GO:BP | GO:0001558 | regulation of cell growth | "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] | 11 | 8.773160e-04 | 0 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 6 | 8.823876e-04 | 0 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 12 | 8.960019e-04 | 0 |
| GO:BP | GO:0031669 | cellular response to nutrient levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 9 | 9.523234e-04 | 0 |
| GO:BP | GO:0072655 | establishment of protein localization to mitochondrion | "The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah] | 7 | 9.591485e-04 | 0 |
| GO:BP | GO:0043488 | regulation of mRNA stability | "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] | 8 | 9.724249e-04 | 0 |
| GO:BP | GO:0061614 | miRNA transcription | "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] | 6 | 1.032646e-03 | 0 |
| GO:BP | GO:0050776 | regulation of immune response | "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 16 | 1.081827e-03 | 0 |
| GO:BP | GO:0016241 | regulation of macroautophagy | "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] | 8 | 1.101708e-03 | 0 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 30 | 1.109871e-03 | 0 |
| GO:BP | GO:0043489 | RNA stabilization | "Prevention of degradation of RNA molecules." [GOC:go_curators] | 6 | 1.115284e-03 | 0 |
| GO:BP | GO:0031667 | response to nutrient levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 12 | 1.128573e-03 | 0 |
| GO:BP | GO:0018209 | peptidyl-serine modification | "The modification of peptidyl-serine." [GOC:go_curators] | 8 | 1.195835e-03 | 0 |
| GO:BP | GO:1902373 | negative regulation of mRNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865] | 6 | 1.203266e-03 | 0 |
| GO:BP | GO:0032881 | regulation of polysaccharide metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah] | 5 | 1.445478e-03 | 0 |
| GO:BP | GO:0048545 | response to steroid hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators] | 10 | 1.455178e-03 | 0 |
| GO:BP | GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 7 | 1.470381e-03 | 0 |
| GO:BP | GO:0002684 | positive regulation of immune system process | "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] | 17 | 1.543824e-03 | 0 |
| GO:BP | GO:0006163 | purine nucleotide metabolic process | "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 11 | 1.544279e-03 | 0 |
| GO:BP | GO:1901875 | positive regulation of post-translational protein modification | "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 7 | 1.547945e-03 | 0 |
| GO:BP | GO:0070585 | protein localization to mitochondrion | "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd] | 7 | 1.547945e-03 | 0 |
| GO:BP | GO:0141188 | nucleic acid catabolic process | "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators] | 10 | 1.575985e-03 | 0 |
| GO:BP | GO:0043487 | regulation of RNA stability | "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] | 8 | 1.581462e-03 | 0 |
| GO:BP | GO:0006289 | nucleotide-excision repair | "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] | 6 | 1.614061e-03 | 0 |
| GO:BP | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] | 6 | 1.614061e-03 | 0 |
| GO:BP | GO:0032386 | regulation of intracellular transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] | 9 | 1.709304e-03 | 0 |
| GO:BP | GO:0050684 | regulation of mRNA processing | "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] | 7 | 1.713408e-03 | 0 |
| GO:BP | GO:1900542 | regulation of purine nucleotide metabolic process | "Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] | 6 | 1.732913e-03 | 0 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 10 | 1.750667e-03 | 0 |
| GO:BP | GO:1905710 | positive regulation of membrane permeability | "Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane." [PMID:27482894] | 5 | 1.813519e-03 | 0 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 13 | 1.815338e-03 | 0 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 47 | 1.821335e-03 | 0 |
| GO:BP | GO:0006140 | regulation of nucleotide metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] | 6 | 1.858835e-03 | 0 |
| GO:BP | GO:1903376 | regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] | 4 | 1.889466e-03 | 0 |
| GO:BP | GO:0043467 | regulation of generation of precursor metabolites and energy | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl] | 7 | 1.893464e-03 | 0 |
| GO:BP | GO:0061013 | regulation of mRNA catabolic process | "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 8 | 1.917954e-03 | 0 |
| GO:BP | GO:0043434 | response to peptide hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] | 11 | 1.933931e-03 | 0 |
| GO:BP | GO:0070201 | regulation of establishment of protein localization | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] | 12 | 1.941855e-03 | 0 |
| GO:BP | GO:0009150 | purine ribonucleotide metabolic process | "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 1.942057e-03 | 0 |
| GO:BP | GO:0000302 | response to reactive oxygen species | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] | 8 | 1.992116e-03 | 0 |
| GO:BP | GO:1905897 | regulation of response to endoplasmic reticulum stress | "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] | 6 | 1.992148e-03 | 0 |
| GO:BP | GO:0002764 | immune response-regulating signaling pathway | "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] | 12 | 2.058480e-03 | 0 |
| GO:BP | GO:0031334 | positive regulation of protein-containing complex assembly | "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] | 8 | 2.147809e-03 | 0 |
| GO:BP | GO:0070842 | aggresome assembly | "The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein." [GOC:BHF, GOC:rl, PMID:14675537] | 3 | 2.184862e-03 | 0 |
| GO:BP | GO:0007017 | microtubule-based process | "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] | 16 | 2.190417e-03 | 0 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 8 | 2.229472e-03 | 0 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 12 | 2.310548e-03 | 0 |
| GO:BP | GO:0044093 | positive regulation of molecular function | "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 15 | 2.448804e-03 | 0 |
| GO:BP | GO:0016236 | macroautophagy | "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339] | 10 | 2.565820e-03 | 0 |
| GO:BP | GO:0001763 | morphogenesis of a branching structure | "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] | 8 | 2.583176e-03 | 0 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 6 | 2.606090e-03 | 0 |
| GO:BP | GO:0032869 | cellular response to insulin stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 8 | 2.678724e-03 | 0 |
| GO:BP | GO:1903313 | positive regulation of mRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 7 | 2.780742e-03 | 0 |
| GO:BP | GO:1902369 | negative regulation of RNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] | 6 | 2.781534e-03 | 0 |
| GO:BP | GO:0036480 | neuron intrinsic apoptotic signaling pathway in response to oxidative stress | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:PARL, PMID:23858059] | 4 | 2.836052e-03 | 0 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 6 | 2.966513e-03 | 0 |
| GO:BP | GO:0009259 | ribonucleotide metabolic process | "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 3.278044e-03 | 0 |
| GO:BP | GO:0034620 | cellular response to unfolded protein | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah] | 6 | 3.366668e-03 | 0 |
| GO:BP | GO:0031648 | protein destabilization | "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah] | 5 | 3.376879e-03 | 0 |
| GO:BP | GO:1900151 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] | 4 | 3.423071e-03 | 0 |
| GO:BP | GO:1903828 | negative regulation of protein localization | "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 8 | 3.557671e-03 | 0 |
| GO:BP | GO:1900182 | positive regulation of protein localization to nucleus | "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 6 | 3.582667e-03 | 0 |
| GO:BP | GO:1903432 | regulation of TORC1 signaling | "Any process that modulates the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie] | 6 | 3.809850e-03 | 0 |
| GO:BP | GO:1905279 | regulation of retrograde transport, endosome to Golgi | "Any process that modulates the frequency, rate or extent of retrograde transport, endosome to Golgi." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23395371] | 3 | 3.812874e-03 | 0 |
| GO:BP | GO:0019693 | ribose phosphate metabolic process | "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 10 | 3.966430e-03 | 0 |
| GO:BP | GO:0032212 | positive regulation of telomere maintenance via telomerase | "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 4 | 4.095668e-03 | 0 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 18 | 4.230857e-03 | 0 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 15 | 4.465990e-03 | 0 |
| GO:BP | GO:0000271 | polysaccharide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] | 5 | 4.479382e-03 | 0 |
| GO:BP | GO:0040029 | epigenetic regulation of gene expression | "A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474] | 9 | 4.489280e-03 | 0 |
| GO:BP | GO:0040007 | growth | "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] | 15 | 4.525530e-03 | 0 |
| GO:BP | GO:0039532 | negative regulation of cytoplasmic pattern recognition receptor signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway." [GOC:bf, GOC:jl] | 5 | 4.903754e-03 | 0 |
| GO:BP | GO:0048754 | branching morphogenesis of an epithelial tube | "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid] | 7 | 4.953651e-03 | 0 |
| GO:BP | GO:0010563 | negative regulation of phosphorus metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 9 | 5.142229e-03 | 0 |
| GO:BP | GO:0045936 | negative regulation of phosphate metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 9 | 5.142229e-03 | 0 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 5 | 5.359113e-03 | 0 |
| GO:BP | GO:0007399 | nervous system development | "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] | 26 | 5.397918e-03 | 0 |
| GO:BP | GO:0051656 | establishment of organelle localization | "The directed movement of an organelle to a specific location." [GOC:ai] | 11 | 5.594186e-03 | 0 |
| GO:BP | GO:1901654 | response to ketone | "A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676] | 8 | 5.689500e-03 | 0 |
| GO:BP | GO:0034612 | response to tumor necrosis factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] | 8 | 5.689500e-03 | 0 |
| GO:BP | GO:0007249 | canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217] | 9 | 5.721992e-03 | 0 |
| GO:BP | GO:2000737 | negative regulation of stem cell differentiation | "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol] | 4 | 5.728640e-03 | 0 |
| GO:BP | GO:0038202 | TORC1 signaling | "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb] | 6 | 5.751785e-03 | 0 |
| GO:BP | GO:0009117 | nucleotide metabolic process | "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] | 11 | 5.816683e-03 | 0 |
| GO:BP | GO:0050807 | regulation of synapse organization | "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] | 9 | 5.875431e-03 | 0 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 8 | 5.876324e-03 | 0 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 7 | 6.100790e-03 | 0 |
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 7 | 6.100790e-03 | 0 |
| GO:BP | GO:0042325 | regulation of phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] | 14 | 6.240283e-03 | 0 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 6 | 6.434427e-03 | 0 |
| GO:BP | GO:0040008 | regulation of growth | "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] | 12 | 6.568638e-03 | 0 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 13 | 7.018772e-03 | 0 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] | 9 | 7.052211e-03 | 0 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] | 20 | 7.330551e-03 | 0 |
| GO:BP | GO:0006338 | chromatin remodeling | "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] | 13 | 7.568377e-03 | 0 |
| GO:BP | GO:0031398 | positive regulation of protein ubiquitination | "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 6 | 7.580902e-03 | 0 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194] | 15 | 7.674421e-03 | 0 |
| GO:BP | GO:0060429 | epithelium development | "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] | 17 | 7.816149e-03 | 0 |
| GO:BP | GO:0060284 | regulation of cell development | "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] | 14 | 7.886956e-03 | 0 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] | 8 | 8.049922e-03 | 0 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 7 | 8.072672e-03 | 0 |
| GO:BP | GO:1903317 | regulation of protein maturation | "Any process that modulates the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 5 | 8.158589e-03 | 0 |
| GO:BP | GO:0006611 | protein export from nucleus | "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] | 5 | 8.158589e-03 | 0 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 19 | 8.182211e-03 | 0 |
| GO:BP | GO:0090140 | regulation of mitochondrial fission | "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] | 4 | 9.021448e-03 | 0 |
| GO:BP | GO:0062207 | regulation of pattern recognition receptor signaling pathway | "Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168] | 7 | 9.066964e-03 | 0 |
| GO:BP | GO:0016052 | carbohydrate catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 7 | 9.420243e-03 | 0 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 13 | 1.016876e-02 | 0 |
| GO:BP | GO:0046824 | positive regulation of nucleocytoplasmic transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] | 5 | 1.032042e-02 | 0 |
| GO:BP | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] | 4 | 1.037893e-02 | 0 |
| GO:BP | GO:0046822 | regulation of nucleocytoplasmic transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] | 6 | 1.147133e-02 | 0 |
| GO:BP | GO:0001503 | ossification | "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] | 10 | 1.186136e-02 | 0 |
| GO:BP | GO:0032007 | negative regulation of TOR signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah] | 5 | 1.290752e-02 | 0 |
| GO:BP | GO:0062098 | regulation of programmed necrotic cell death | "Any process that modulates the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785] | 4 | 1.353939e-02 | 0 |
| GO:BP | GO:0009314 | response to radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] | 10 | 1.366450e-02 | 0 |
| GO:BP | GO:0090559 | regulation of membrane permeability | "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane." [GOC:kmv, PMID:22677064] | 5 | 1.387412e-02 | 0 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:22651914, PMID:28096268] | 9 | 1.401548e-02 | 0 |
| GO:BP | GO:0038061 | non-canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217] | 6 | 1.534320e-02 | 0 |
| GO:BP | GO:0000423 | mitophagy | "The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367] | 5 | 1.597687e-02 | 0 |
| GO:BP | GO:0000380 | alternative mRNA splicing, via spliceosome | "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] | 5 | 1.597687e-02 | 0 |
| GO:BP | GO:0000724 | double-strand break repair via homologous recombination | "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] | 7 | 1.625885e-02 | 0 |
| GO:BP | GO:0061138 | morphogenesis of a branching epithelium | "The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph] | 7 | 1.683227e-02 | 0 |
| GO:BP | GO:0032886 | regulation of microtubule-based process | "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] | 8 | 1.711139e-02 | 0 |
| GO:BP | GO:0051881 | regulation of mitochondrial membrane potential | "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai] | 5 | 1.711761e-02 | 0 |
| GO:BP | GO:0043516 | regulation of DNA damage response, signal transduction by p53 class mediator | "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] | 4 | 1.735920e-02 | 0 |
| GO:BP | GO:0006983 | ER overload response | "The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516] | 3 | 1.777590e-02 | 0 |
| GO:BP | GO:0071248 | cellular response to metal ion | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah] | 7 | 1.865425e-02 | 0 |
| GO:BP | GO:0032868 | response to insulin | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 8 | 1.907480e-02 | 0 |
| GO:BP | GO:0000725 | recombinational repair | "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] | 7 | 1.929677e-02 | 0 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 11 | 1.947264e-02 | 0 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 11 | 1.947264e-02 | 0 |
| GO:BP | GO:1903578 | regulation of ATP metabolic process | "Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] | 5 | 1.958968e-02 | 0 |
| GO:BP | GO:0072521 | purine-containing compound metabolic process | "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 11 | 2.047163e-02 | 0 |
| GO:BP | GO:0050808 | synapse organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] | 11 | 2.047163e-02 | 0 |
| GO:BP | GO:0016242 | negative regulation of macroautophagy | "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] | 4 | 2.192029e-02 | 0 |
| GO:BP | GO:0046825 | regulation of protein export from nucleus | "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf] | 4 | 2.192029e-02 | 0 |
| GO:BP | GO:0007178 | cell surface receptor protein serine/threonine kinase signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] | 9 | 2.203591e-02 | 0 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 5 | 2.233231e-02 | 0 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 37 | 2.295057e-02 | 0 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] | 6 | 2.307955e-02 | 0 |
| GO:BP | GO:0050679 | positive regulation of epithelial cell proliferation | "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai] | 7 | 2.766236e-02 | 0 |
| GO:BP | GO:0045913 | positive regulation of carbohydrate metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] | 5 | 2.871205e-02 | 0 |
| GO:BP | GO:2000736 | regulation of stem cell differentiation | "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol] | 5 | 2.871205e-02 | 0 |
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] | 10 | 2.977285e-02 | 0 |
| GO:BP | GO:0006810 | transport | "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] | 34 | 2.985151e-02 | 0 |
| GO:BP | GO:0031571 | mitotic G1 DNA damage checkpoint signaling | "A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle] | 3 | 3.064054e-02 | 0 |
| GO:BP | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15790595] | 3 | 3.064054e-02 | 0 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] | 7 | 3.136540e-02 | 0 |
| GO:BP | GO:0071356 | cellular response to tumor necrosis factor | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] | 7 | 3.136540e-02 | 0 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 19 | 3.291163e-02 | 0 |
| GO:BP | GO:0090199 | regulation of release of cytochrome c from mitochondria | "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 4 | 3.361317e-02 | 0 |
| GO:BP | GO:0070266 | necroptotic process | "A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former." [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153] | 4 | 3.361317e-02 | 0 |
| GO:BP | GO:0032388 | positive regulation of intracellular transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] | 6 | 3.370707e-02 | 0 |
| GO:BP | GO:0034330 | cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] | 13 | 3.393136e-02 | 0 |
| GO:BP | GO:0010212 | response to ionizing radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] | 6 | 3.509786e-02 | 0 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 21 | 3.520937e-02 | 0 |
| GO:BP | GO:0006094 | gluconeogenesis | "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] | 5 | 3.643108e-02 | 0 |
| GO:BP | GO:0031333 | negative regulation of protein-containing complex assembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] | 6 | 3.653460e-02 | 0 |
| GO:BP | GO:0071383 | cellular response to steroid hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah] | 7 | 3.656202e-02 | 0 |
| GO:BP | GO:0000266 | mitochondrial fission | "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] | 4 | 3.713821e-02 | 0 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 10 | 3.815416e-02 | 0 |
| GO:BP | GO:0044819 | mitotic G1/S transition checkpoint signaling | "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 3.888869e-02 | 0 |
| GO:BP | GO:0160049 | negative regulation of cGAS/STING signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of cGAS/STING signaling pathway." [PMID:29875158] | 3 | 3.888869e-02 | 0 |
| GO:BP | GO:2000377 | regulation of reactive oxygen species metabolic process | "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] | 6 | 3.955051e-02 | 0 |
| GO:BP | GO:0035794 | positive regulation of mitochondrial membrane permeability | "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf, PMID:12546810] | 4 | 4.092759e-02 | 0 |
| GO:BP | GO:0062013 | positive regulation of small molecule metabolic process | "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] | 6 | 4.113200e-02 | 0 |
| GO:BP | GO:1901135 | carbohydrate derivative metabolic process | "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] | 14 | 4.247922e-02 | 0 |
| GO:BP | GO:0019319 | hexose biosynthetic process | "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] | 5 | 4.321193e-02 | 0 |
| GO:BP | GO:1990000 | amyloid fibril formation | "The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins." [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:21148556, PMID:22817896, PMID:28937655, PMID:29654159] | 4 | 4.499349e-02 | 0 |
| GO:BP | GO:0048729 | tissue morphogenesis | "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] | 11 | 4.576130e-02 | 0 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] | 10 | 4.609504e-02 | 0 |
| GO:BP | GO:0036294 | cellular response to decreased oxygen levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] | 6 | 4.797607e-02 | 0 |
| GO:BP | GO:0061684 | chaperone-mediated autophagy | "The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded." [GOC:pad, GOC:PARL, PMID:22743996, PMID:23434281] | 3 | 4.847582e-02 | 0 |
| GO:BP | GO:0010907 | positive regulation of glucose metabolic process | "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] | 4 | 4.934829e-02 | 0 |
| GO:BP | GO:1903146 | regulation of autophagy of mitochondrion | "Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process." [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391] | 4 | 4.934829e-02 | 0 |
| GO:BP | GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process | "Any regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129] | 4 | 4.934829e-02 | 0 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 6 | 4.982280e-02 | 0 |
| GO:BP | GO:0022607 | cellular component assembly | "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] | 35 | 4.983739e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 58 | 1.352232e-21 | 0 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 69 | 1.493632e-21 | 0 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 69 | 1.493632e-21 | 0 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 69 | 1.493632e-21 | 0 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 67 | 1.452048e-19 | 0 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 67 | 1.465393e-19 | 0 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 62 | 2.370057e-19 | 0 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 61 | 2.268347e-18 | 0 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 73 | 3.883946e-14 | 0 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 36 | 1.119850e-13 | 0 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 36 | 1.748509e-13 | 0 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 36 | 1.774447e-13 | 0 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 36 | 1.774447e-13 | 0 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 33 | 8.655008e-12 | 0 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 63 | 1.266837e-11 | 0 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 34 | 2.463901e-10 | 0 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 22 | 2.468290e-10 | 0 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 43 | 7.591849e-10 | 0 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 74 | 6.861162e-09 | 0 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 12 | 5.652027e-08 | 0 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 24 | 7.339068e-08 | 0 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 36 | 9.083824e-08 | 0 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 78 | 1.006422e-07 | 0 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 12 | 1.276749e-07 | 0 |
| GO:CC | GO:0098978 | glutamatergic synapse | "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] | 16 | 1.678032e-07 | 0 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 25 | 2.211907e-07 | 0 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 9 | 2.432853e-07 | 0 |
| GO:CC | GO:0016363 | nuclear matrix | "A dynamic, proteinaceous framework within the nucleus of eukaryotic cells, composed of proteins and RNA, that provides structural support for chromatin organization, gene regulation, and nuclear processes." [PMID:15608168, PMID:3058729, PMID:39789220] | 9 | 3.461664e-07 | 0 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 80 | 7.555874e-07 | 0 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 79 | 1.496496e-06 | 0 |
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 10 | 1.626139e-06 | 0 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 81 | 2.031236e-06 | 0 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 14 | 2.069376e-06 | 0 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 30 | 2.814422e-06 | 0 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 38 | 6.405273e-06 | 0 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 9 | 7.832324e-06 | 0 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 11 | 8.671752e-06 | 0 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 82 | 8.922390e-06 | 0 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 11 | 1.014404e-05 | 0 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 11 | 1.046389e-05 | 0 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 21 | 1.126580e-05 | 0 |
| GO:CC | GO:0071013 | catalytic step 2 spliceosome | "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 7 | 1.344945e-05 | 0 |
| GO:CC | GO:0010494 | cytoplasmic stress granule | "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] | 7 | 1.564882e-05 | 0 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 12 | 1.569124e-05 | 0 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 12 | 2.019920e-05 | 0 |
| GO:CC | GO:0035861 | site of double-strand break | "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] | 7 | 2.251571e-05 | 0 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 27 | 3.615810e-05 | 0 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 27 | 7.043558e-05 | 0 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 27 | 7.387205e-05 | 0 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 11 | 8.277924e-05 | 0 |
| GO:CC | GO:0016234 | inclusion body | "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744] | 6 | 8.681308e-05 | 0 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 16 | 9.275721e-05 | 0 |
| GO:CC | GO:0016607 | nuclear speck | "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640] | 11 | 1.188251e-04 | 0 |
| GO:CC | GO:0090734 | site of DNA damage | "A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg] | 7 | 1.483818e-04 | 0 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 19 | 1.891471e-04 | 0 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 15 | 3.245092e-04 | 0 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 58 | 5.754165e-04 | 0 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 16 | 6.669433e-04 | 0 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 7 | 9.818614e-04 | 0 |
| GO:CC | GO:0048471 | perinuclear region of cytoplasm | "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] | 13 | 9.846097e-04 | 0 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 6 | 1.205611e-03 | 0 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 6 | 1.205611e-03 | 0 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 8 | 1.414332e-03 | 0 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 24 | 1.480126e-03 | 0 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 13 | 1.574971e-03 | 0 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 14 | 1.612614e-03 | 0 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 15 | 2.234313e-03 | 0 |
| GO:CC | GO:0008180 | COP9 signalosome | "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] | 4 | 2.433407e-03 | 0 |
| GO:CC | GO:0016235 | aggresome | "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744] | 4 | 2.433407e-03 | 0 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 15 | 2.442859e-03 | 0 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 5 | 2.517229e-03 | 0 |
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 20 | 2.722135e-03 | 0 |
| GO:CC | GO:0035525 | NF-kappaB p50/p65 complex | "A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584] | 2 | 3.935970e-03 | 0 |
| GO:CC | GO:0042382 | paraspeckles | "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299] | 3 | 3.958819e-03 | 0 |
| GO:CC | GO:1990909 | Wnt signalosome | "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320] | 3 | 3.958819e-03 | 0 |
| GO:CC | GO:0005662 | DNA replication factor A complex | "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] | 3 | 3.958819e-03 | 0 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 10 | 3.969640e-03 | 0 |
| GO:CC | GO:0043596 | nuclear replication fork | "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] | 4 | 4.627678e-03 | 0 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 19 | 5.962456e-03 | 0 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 35 | 6.340488e-03 | 0 |
| GO:CC | GO:0031967 | organelle envelope | "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] | 16 | 7.269825e-03 | 0 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 22 | 7.474431e-03 | 0 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 7 | 7.781583e-03 | 0 |
| GO:CC | GO:0031252 | cell leading edge | "The area of a motile cell closest to the direction of movement." [GOC:pg] | 9 | 9.262455e-03 | 0 |
| GO:CC | GO:0044297 | cell body | "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] | 10 | 1.347643e-02 | 0 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 12 | 1.395089e-02 | 0 |
| GO:CC | GO:0043601 | nuclear replisome | "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] | 3 | 2.080990e-02 | 0 |
| GO:CC | GO:0030894 | replisome | "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] | 3 | 2.720442e-02 | 0 |
| GO:CC | GO:0099523 | presynaptic cytosol | "The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos] | 3 | 3.083165e-02 | 0 |
| GO:CC | GO:0106002 | mCRD-mediated mRNA stability complex | "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP." [GOC:bhm, PMID:11051545] | 2 | 3.907611e-02 | 0 |
| GO:CC | GO:0071159 | NF-kappaB complex | "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946] | 2 | 3.907611e-02 | 0 |
| GO:CC | GO:0099568 | cytoplasmic region | "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos] | 7 | 4.698874e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 34 | 4.623889e-20 | 0 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 40 | 3.883022e-17 | 0 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 27 | 1.460884e-15 | 0 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 42 | 1.534429e-15 | 0 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 22 | 2.576620e-15 | 0 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 29 | 7.934644e-15 | 0 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 34 | 1.326303e-14 | 0 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 28 | 4.552753e-14 | 0 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 29 | 9.742256e-14 | 0 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 30 | 1.986550e-13 | 0 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 26 | 2.297731e-13 | 0 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 31 | 4.147295e-13 | 0 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 29 | 4.728975e-13 | 0 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 28 | 4.984789e-13 | 0 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 27 | 5.193053e-13 | 0 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 27 | 6.801092e-13 | 0 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 20 | 7.798583e-13 | 0 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 28 | 1.061555e-12 | 0 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 27 | 1.198973e-12 | 0 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 29 | 1.265958e-12 | 0 |
| HPA | HPA:0471492 | Skin 2; vascular mural cells[≥Medium] | Skin 2; vascular mural cells[≥Medium] | 17 | 1.431156e-12 | 0 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 27 | 2.588041e-12 | 0 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 22 | 2.632375e-12 | 0 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 30 | 3.354050e-12 | 0 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 28 | 3.542310e-12 | 0 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 41 | 4.053059e-12 | 0 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 26 | 4.591394e-12 | 0 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 29 | 5.219527e-12 | 0 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 37 | 6.061170e-12 | 0 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 29 | 6.689872e-12 | 0 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 27 | 6.926940e-12 | 0 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 25 | 7.524266e-12 | 0 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 25 | 7.820674e-12 | 0 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 34 | 1.062898e-11 | 0 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 27 | 1.077659e-11 | 0 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 59 | 1.472256e-11 | 0 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 28 | 1.619547e-11 | 0 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 29 | 1.656461e-11 | 0 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 32 | 1.682928e-11 | 0 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 24 | 1.894601e-11 | 0 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 29 | 2.222844e-11 | 0 |
| HPA | HPA:0461393 | Skin 1; cells in basal layer[High] | Skin 1; cells in basal layer[High] | 16 | 2.370298e-11 | 0 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 29 | 2.497600e-11 | 0 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 22 | 2.597811e-11 | 0 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 14 | 2.671247e-11 | 0 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 58 | 3.023426e-11 | 0 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 24 | 3.661023e-11 | 0 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 24 | 4.102774e-11 | 0 |
| HPA | HPA:0510653 | Soft tissue 2; fibroblasts[High] | Soft tissue 2; fibroblasts[High] | 23 | 4.301719e-11 | 0 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 19 | 4.484353e-11 | 0 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 14 | 5.062134e-11 | 0 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 13 | 5.596380e-11 | 0 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 17 | 5.809363e-11 | 0 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 26 | 6.274146e-11 | 0 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 42 | 8.011230e-11 | 0 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 54 | 1.091049e-10 | 0 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 30 | 1.392606e-10 | 0 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 20 | 1.751108e-10 | 0 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 16 | 1.862026e-10 | 0 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 30 | 2.037621e-10 | 0 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 29 | 2.099657e-10 | 0 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 52 | 2.134528e-10 | 0 |
| HPA | HPA:0400651 | Rectum; fibroblasts[≥Low] | Rectum; fibroblasts[≥Low] | 13 | 2.775216e-10 | 0 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 37 | 3.262354e-10 | 0 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 15 | 3.382278e-10 | 0 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 21 | 4.157799e-10 | 0 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 18 | 4.351700e-10 | 0 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 31 | 5.282875e-10 | 0 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 57 | 7.273921e-10 | 0 |
| HPA | HPA:0500653 | Soft tissue 1; fibroblasts[High] | Soft tissue 1; fibroblasts[High] | 22 | 8.177697e-10 | 0 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 28 | 8.818598e-10 | 0 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 63 | 9.681522e-10 | 0 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 15 | 1.270437e-09 | 0 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 38 | 1.747679e-09 | 0 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 34 | 1.965356e-09 | 0 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 30 | 2.403724e-09 | 0 |
| HPA | HPA:0510652 | Soft tissue 2; fibroblasts[≥Medium] | Soft tissue 2; fibroblasts[≥Medium] | 45 | 2.468841e-09 | 0 |
| HPA | HPA:0050093 | Breast; myoepithelial cells[High] | Breast; myoepithelial cells[High] | 26 | 2.502786e-09 | 0 |
| HPA | HPA:0570773 | Testis; peritubular cells[High] | Testis; peritubular cells[High] | 15 | 2.510263e-09 | 0 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 18 | 3.226633e-09 | 0 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 62 | 3.646620e-09 | 0 |
| HPA | HPA:0400202 | Rectum; endothelial cells[≥Medium] | Rectum; endothelial cells[≥Medium] | 14 | 3.908827e-09 | 0 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 16 | 3.911759e-09 | 0 |
| HPA | HPA:0340000 | Ovary | Ovary | 64 | 4.498548e-09 | 0 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 32 | 5.899447e-09 | 0 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 65 | 8.595251e-09 | 0 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 18 | 8.734728e-09 | 0 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 57 | 1.063879e-08 | 0 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 33 | 1.107650e-08 | 0 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 15 | 1.194336e-08 | 0 |
| HPA | HPA:0050012 | Breast; adipocytes[≥Medium] | Breast; adipocytes[≥Medium] | 33 | 1.514204e-08 | 0 |
| HPA | HPA:0510703 | Soft tissue 2; peripheral nerve[High] | Soft tissue 2; peripheral nerve[High] | 16 | 1.672638e-08 | 0 |
| HPA | HPA:0400201 | Rectum; endothelial cells[≥Low] | Rectum; endothelial cells[≥Low] | 15 | 2.371092e-08 | 0 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 31 | 2.382981e-08 | 0 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 66 | 2.384865e-08 | 0 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 69 | 2.740145e-08 | 0 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 43 | 3.027310e-08 | 0 |
| HPA | HPA:0170253 | Endometrium 2; cells in endometrial stroma[High] | Endometrium 2; cells in endometrial stroma[High] | 17 | 3.499071e-08 | 0 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 34 | 5.414412e-08 | 0 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 32 | 5.801652e-08 | 0 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 29 | 5.827589e-08 | 0 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 37 | 5.966476e-08 | 0 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 53 | 1.034825e-07 | 0 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 60 | 1.114380e-07 | 0 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 69 | 1.216217e-07 | 0 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 25 | 1.227256e-07 | 0 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 70 | 1.289411e-07 | 0 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 59 | 1.573558e-07 | 0 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 46 | 1.573844e-07 | 0 |
| HPA | HPA:0270353 | Kidney; cells in glomeruli[High] | Kidney; cells in glomeruli[High] | 24 | 1.586174e-07 | 0 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 37 | 1.800510e-07 | 0 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 59 | 1.872298e-07 | 0 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 14 | 1.945488e-07 | 0 |
| HPA | HPA:0010013 | Adipose tissue; adipocytes[High] | Adipose tissue; adipocytes[High] | 18 | 2.067816e-07 | 0 |
| HPA | HPA:0351183 | Pancreas; pancreatic endocrine cells[High] | Pancreas; pancreatic endocrine cells[High] | 23 | 2.783207e-07 | 0 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 69 | 3.144587e-07 | 0 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 28 | 3.254401e-07 | 0 |
| HPA | HPA:0630000 | Cervix | Cervix | 69 | 3.316354e-07 | 0 |
| HPA | HPA:0050013 | Breast; adipocytes[High] | Breast; adipocytes[High] | 15 | 3.815158e-07 | 0 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 14 | 3.982972e-07 | 0 |
| HPA | HPA:0050000 | Breast | Breast | 70 | 3.998893e-07 | 0 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 43 | 4.243524e-07 | 0 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 39 | 4.307914e-07 | 0 |
| HPA | HPA:0130651 | Colon; fibroblasts[≥Low] | Colon; fibroblasts[≥Low] | 10 | 4.506514e-07 | 0 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 60 | 4.533051e-07 | 0 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 70 | 4.643750e-07 | 0 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 55 | 4.708798e-07 | 0 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 43 | 4.896740e-07 | 0 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 58 | 5.221901e-07 | 0 |
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 29 | 5.235266e-07 | 0 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 21 | 5.323403e-07 | 0 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 42 | 5.534903e-07 | 0 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 50 | 5.679366e-07 | 0 |
| HPA | HPA:0390053 | Prostate; glandular cells[High] | Prostate; glandular cells[High] | 29 | 6.353180e-07 | 0 |
| HPA | HPA:0160253 | Endometrium 1; cells in endometrial stroma[High] | Endometrium 1; cells in endometrial stroma[High] | 17 | 6.974256e-07 | 0 |
| HPA | HPA:0060103 | Bronchus; respiratory epithelial cells[High] | Bronchus; respiratory epithelial cells[High] | 34 | 8.114068e-07 | 0 |
| HPA | HPA:0630053 | Cervix; glandular cells[High] | Cervix; glandular cells[High] | 27 | 9.353512e-07 | 0 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 34 | 1.052734e-06 | 0 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 60 | 1.082157e-06 | 0 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 70 | 1.098908e-06 | 0 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 70 | 1.098908e-06 | 0 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 15 | 1.101927e-06 | 0 |
| HPA | HPA:0030000 | Appendix | Appendix | 72 | 1.112057e-06 | 0 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 54 | 1.254169e-06 | 0 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 30 | 1.267574e-06 | 0 |
| HPA | HPA:0500703 | Soft tissue 1; peripheral nerve[High] | Soft tissue 1; peripheral nerve[High] | 13 | 1.450889e-06 | 0 |
| HPA | HPA:0570771 | Testis; peritubular cells[≥Low] | Testis; peritubular cells[≥Low] | 21 | 1.470268e-06 | 0 |
| HPA | HPA:0131333 | Colon; mucosal lymphoid cells[High] | Colon; mucosal lymphoid cells[High] | 11 | 1.483744e-06 | 0 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 70 | 1.497289e-06 | 0 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 70 | 1.497289e-06 | 0 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 51 | 1.502118e-06 | 0 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 51 | 1.502118e-06 | 0 |
| HPA | HPA:0440343 | Skeletal muscle; myocytes[High] | Skeletal muscle; myocytes[High] | 23 | 1.530033e-06 | 0 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 34 | 1.658451e-06 | 0 |
| HPA | HPA:0570772 | Testis; peritubular cells[≥Medium] | Testis; peritubular cells[≥Medium] | 18 | 1.793243e-06 | 0 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 33 | 1.862979e-06 | 0 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 63 | 1.870883e-06 | 0 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 63 | 1.870883e-06 | 0 |
| HPA | HPA:0400653 | Rectum; fibroblasts[High] | Rectum; fibroblasts[High] | 8 | 1.913621e-06 | 0 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 13 | 2.048643e-06 | 0 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 13 | 2.048643e-06 | 0 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 52 | 2.265995e-06 | 0 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 37 | 2.563316e-06 | 0 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 67 | 2.686828e-06 | 0 |
| HPA | HPA:0570783 | Testis; preleptotene spermatocytes[High] | Testis; preleptotene spermatocytes[High] | 21 | 2.809713e-06 | 0 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 54 | 3.126652e-06 | 0 |
| HPA | HPA:0400000 | Rectum | Rectum | 72 | 3.685087e-06 | 0 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 41 | 3.723743e-06 | 0 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 27 | 3.753204e-06 | 0 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 18 | 3.910846e-06 | 0 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 49 | 4.555081e-06 | 0 |
| HPA | HPA:0130243 | Colon; peripheral nerve/ganglion[High] | Colon; peripheral nerve/ganglion[High] | 22 | 5.218579e-06 | 0 |
| HPA | HPA:0300413 | Lung; macrophages[High] | Lung; macrophages[High] | 28 | 5.386612e-06 | 0 |
| HPA | HPA:0400203 | Rectum; endothelial cells[High] | Rectum; endothelial cells[High] | 9 | 5.551581e-06 | 0 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 11 | 5.562307e-06 | 0 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 67 | 5.905598e-06 | 0 |
| HPA | HPA:0131302 | Colon; enterocytes[≥Medium] | Colon; enterocytes[≥Medium] | 15 | 6.010663e-06 | 0 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 15 | 7.661994e-06 | 0 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 64 | 8.232420e-06 | 0 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 64 | 8.232420e-06 | 0 |
| HPA | HPA:0130892 | Colon; goblet cells[≥Medium] | Colon; goblet cells[≥Medium] | 14 | 9.546611e-06 | 0 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 66 | 1.025702e-05 | 0 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 66 | 1.025702e-05 | 0 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 48 | 1.118959e-05 | 0 |
| HPA | HPA:0480892 | Small intestine; goblet cells[≥Medium] | Small intestine; goblet cells[≥Medium] | 14 | 1.148450e-05 | 0 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 65 | 1.216339e-05 | 0 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 65 | 1.216339e-05 | 0 |
| HPA | HPA:0131292 | Colon; endocrine cells[≥Medium] | Colon; endocrine cells[≥Medium] | 15 | 1.226321e-05 | 0 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 68 | 1.231949e-05 | 0 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 68 | 1.231949e-05 | 0 |
| HPA | HPA:0400242 | Rectum; peripheral nerve/ganglion[≥Medium] | Rectum; peripheral nerve/ganglion[≥Medium] | 11 | 1.288900e-05 | 0 |
| HPA | HPA:0270352 | Kidney; cells in glomeruli[≥Medium] | Kidney; cells in glomeruli[≥Medium] | 43 | 1.305612e-05 | 0 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 63 | 1.314968e-05 | 0 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 40 | 1.329852e-05 | 0 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 15 | 1.352946e-05 | 0 |
| HPA | HPA:0570803 | Testis; sertoli cells[High] | Testis; sertoli cells[High] | 18 | 1.440824e-05 | 0 |
| HPA | HPA:0300000 | Lung | Lung | 69 | 1.468672e-05 | 0 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 65 | 1.564813e-05 | 0 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 50 | 1.596526e-05 | 0 |
| HPA | HPA:0481303 | Small intestine; enterocytes[High] | Small intestine; enterocytes[High] | 12 | 1.719486e-05 | 0 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 60 | 1.745806e-05 | 0 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 59 | 1.779670e-05 | 0 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 69 | 2.012539e-05 | 0 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 62 | 2.127206e-05 | 0 |
| HPA | HPA:0620000 | Vagina | Vagina | 62 | 2.127206e-05 | 0 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 69 | 2.129062e-05 | 0 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 51 | 2.177696e-05 | 0 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 68 | 2.185061e-05 | 0 |
| HPA | HPA:0130653 | Colon; fibroblasts[High] | Colon; fibroblasts[High] | 7 | 2.201330e-05 | 0 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 66 | 2.339526e-05 | 0 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 51 | 2.358730e-05 | 0 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 69 | 2.440105e-05 | 0 |
| HPA | HPA:0130893 | Colon; goblet cells[High] | Colon; goblet cells[High] | 11 | 2.519818e-05 | 0 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 57 | 2.591502e-05 | 0 |
| HPA | HPA:0130203 | Colon; endothelial cells[High] | Colon; endothelial cells[High] | 21 | 2.607017e-05 | 0 |
| HPA | HPA:0461453 | Skin 1; hair follicles[High] | Skin 1; hair follicles[High] | 9 | 2.656092e-05 | 0 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 14 | 2.765407e-05 | 0 |
| HPA | HPA:0480893 | Small intestine; goblet cells[High] | Small intestine; goblet cells[High] | 11 | 2.781622e-05 | 0 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 28 | 2.884349e-05 | 0 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 51 | 2.940360e-05 | 0 |
| HPA | HPA:0031292 | Appendix; endocrine cells[≥Medium] | Appendix; endocrine cells[≥Medium] | 14 | 2.957736e-05 | 0 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 69 | 3.175311e-05 | 0 |
| HPA | HPA:0400241 | Rectum; peripheral nerve/ganglion[≥Low] | Rectum; peripheral nerve/ganglion[≥Low] | 12 | 3.293060e-05 | 0 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 13 | 3.332971e-05 | 0 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 67 | 3.341724e-05 | 0 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 33 | 3.362859e-05 | 0 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 22 | 3.366212e-05 | 0 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 53 | 3.524435e-05 | 0 |
| HPA | HPA:0400893 | Rectum; goblet cells[High] | Rectum; goblet cells[High] | 11 | 3.544770e-05 | 0 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 55 | 3.772175e-05 | 0 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 50 | 3.803920e-05 | 0 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 35 | 3.808171e-05 | 0 |
| HPA | HPA:0530000 | Spleen | Spleen | 61 | 4.005726e-05 | 0 |
| HPA | HPA:0500113 | Soft tissue 1; chondrocytes[High] | Soft tissue 1; chondrocytes[High] | 13 | 4.302690e-05 | 0 |
| HPA | HPA:0291163 | Liver; cholangiocytes[High] | Liver; cholangiocytes[High] | 13 | 4.460186e-05 | 0 |
| HPA | HPA:0131303 | Colon; enterocytes[High] | Colon; enterocytes[High] | 11 | 4.488339e-05 | 0 |
| HPA | HPA:0380000 | Placenta | Placenta | 69 | 4.570361e-05 | 0 |
| HPA | HPA:0131291 | Colon; endocrine cells[≥Low] | Colon; endocrine cells[≥Low] | 15 | 4.778709e-05 | 0 |
| HPA | HPA:0130652 | Colon; fibroblasts[≥Medium] | Colon; fibroblasts[≥Medium] | 8 | 5.489970e-05 | 0 |
| HPA | HPA:0401291 | Rectum; endocrine cells[≥Low] | Rectum; endocrine cells[≥Low] | 15 | 5.520662e-05 | 0 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 66 | 6.021189e-05 | 0 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 66 | 6.021189e-05 | 0 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 70 | 6.127818e-05 | 0 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 61 | 6.236135e-05 | 0 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 54 | 6.630170e-05 | 0 |
| HPA | HPA:0401303 | Rectum; enterocytes[High] | Rectum; enterocytes[High] | 11 | 7.066685e-05 | 0 |
| HPA | HPA:0500702 | Soft tissue 1; peripheral nerve[≥Medium] | Soft tissue 1; peripheral nerve[≥Medium] | 26 | 7.083965e-05 | 0 |
| HPA | HPA:0481292 | Small intestine; endocrine cells[≥Medium] | Small intestine; endocrine cells[≥Medium] | 15 | 7.124067e-05 | 0 |
| HPA | HPA:0130000 | Colon | Colon | 72 | 7.407471e-05 | 0 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 57 | 7.768309e-05 | 0 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 63 | 7.818901e-05 | 0 |
| HPA | HPA:0241103 | Heart muscle; cardiomyocytes[High] | Heart muscle; cardiomyocytes[High] | 24 | 7.924293e-05 | 0 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 14 | 7.959564e-05 | 0 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 66 | 8.266510e-05 | 0 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 36 | 9.171508e-05 | 0 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 13 | 9.218438e-05 | 0 |
| HPA | HPA:0481293 | Small intestine; endocrine cells[High] | Small intestine; endocrine cells[High] | 12 | 9.574309e-05 | 0 |
| HPA | HPA:0080000 | Caudate | Caudate | 66 | 9.861705e-05 | 0 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 71 | 1.000684e-04 | 0 |
| HPA | HPA:0130242 | Colon; peripheral nerve/ganglion[≥Medium] | Colon; peripheral nerve/ganglion[≥Medium] | 44 | 1.006896e-04 | 0 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 57 | 1.032919e-04 | 0 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 59 | 1.049565e-04 | 0 |
| HPA | HPA:0480891 | Small intestine; goblet cells[≥Low] | Small intestine; goblet cells[≥Low] | 14 | 1.106529e-04 | 0 |
| HPA | HPA:0031303 | Appendix; enterocytes[High] | Appendix; enterocytes[High] | 10 | 1.142833e-04 | 0 |
| HPA | HPA:0130891 | Colon; goblet cells[≥Low] | Colon; goblet cells[≥Low] | 14 | 1.173495e-04 | 0 |
| HPA | HPA:0031301 | Appendix; enterocytes[≥Low] | Appendix; enterocytes[≥Low] | 15 | 1.197032e-04 | 0 |
| HPA | HPA:0490693 | Smooth muscle; smooth muscle cells[High] | Smooth muscle; smooth muscle cells[High] | 17 | 1.236085e-04 | 0 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 64 | 1.369707e-04 | 0 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 22 | 1.398412e-04 | 0 |
| HPA | HPA:0031291 | Appendix; endocrine cells[≥Low] | Appendix; endocrine cells[≥Low] | 14 | 1.437597e-04 | 0 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 70 | 1.442373e-04 | 0 |
| HPA | HPA:0031302 | Appendix; enterocytes[≥Medium] | Appendix; enterocytes[≥Medium] | 13 | 1.701695e-04 | 0 |
| HPA | HPA:0151291 | Duodenum; endocrine cells[≥Low] | Duodenum; endocrine cells[≥Low] | 15 | 1.727050e-04 | 0 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 45 | 1.763481e-04 | 0 |
| HPA | HPA:0481291 | Small intestine; endocrine cells[≥Low] | Small intestine; endocrine cells[≥Low] | 15 | 1.772000e-04 | 0 |
| HPA | HPA:0131293 | Colon; endocrine cells[High] | Colon; endocrine cells[High] | 11 | 1.849570e-04 | 0 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 52 | 1.905010e-04 | 0 |
| HPA | HPA:0400243 | Rectum; peripheral nerve/ganglion[High] | Rectum; peripheral nerve/ganglion[High] | 8 | 1.934124e-04 | 0 |
| HPA | HPA:0290000 | Liver | Liver | 62 | 2.084014e-04 | 0 |
| HPA | HPA:0390000 | Prostate | Prostate | 64 | 2.165544e-04 | 0 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 64 | 2.165544e-04 | 0 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 34 | 2.312061e-04 | 0 |
| HPA | HPA:0131301 | Colon; enterocytes[≥Low] | Colon; enterocytes[≥Low] | 15 | 2.400154e-04 | 0 |
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 31 | 2.572422e-04 | 0 |
| HPA | HPA:0510702 | Soft tissue 2; peripheral nerve[≥Medium] | Soft tissue 2; peripheral nerve[≥Medium] | 27 | 2.601385e-04 | 0 |
| HPA | HPA:0150893 | Duodenum; goblet cells[High] | Duodenum; goblet cells[High] | 10 | 2.633732e-04 | 0 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 14 | 2.651677e-04 | 0 |
| HPA | HPA:0131331 | Colon; mucosal lymphoid cells[≥Low] | Colon; mucosal lymphoid cells[≥Low] | 15 | 2.716517e-04 | 0 |
| HPA | HPA:0401301 | Rectum; enterocytes[≥Low] | Rectum; enterocytes[≥Low] | 15 | 2.923917e-04 | 0 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 58 | 3.351380e-04 | 0 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 18 | 3.395765e-04 | 0 |
| HPA | HPA:0030891 | Appendix; goblet cells[≥Low] | Appendix; goblet cells[≥Low] | 13 | 3.401707e-04 | 0 |
| HPA | HPA:0401293 | Rectum; endocrine cells[High] | Rectum; endocrine cells[High] | 11 | 3.665735e-04 | 0 |
| HPA | HPA:0130202 | Colon; endothelial cells[≥Medium] | Colon; endothelial cells[≥Medium] | 45 | 3.745978e-04 | 0 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 35 | 3.970324e-04 | 0 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 56 | 4.340661e-04 | 0 |
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 30 | 4.396679e-04 | 0 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 22 | 4.604554e-04 | 0 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 61 | 4.685692e-04 | 0 |
| HPA | HPA:0570782 | Testis; preleptotene spermatocytes[≥Medium] | Testis; preleptotene spermatocytes[≥Medium] | 26 | 4.777278e-04 | 0 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 12 | 4.911429e-04 | 0 |
| HPA | HPA:0030073 | Appendix; lymphoid tissue[High] | Appendix; lymphoid tissue[High] | 18 | 4.966516e-04 | 0 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 68 | 5.063444e-04 | 0 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 68 | 5.063444e-04 | 0 |
| HPA | HPA:0570792 | Testis; round or early spermatids[≥Medium] | Testis; round or early spermatids[≥Medium] | 30 | 5.090167e-04 | 0 |
| HPA | HPA:0340452 | Ovary; follicle cells[≥Medium] | Ovary; follicle cells[≥Medium] | 33 | 5.232067e-04 | 0 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 60 | 5.267100e-04 | 0 |
| HPA | HPA:0151301 | Duodenum; enterocytes[≥Low] | Duodenum; enterocytes[≥Low] | 15 | 5.414060e-04 | 0 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 55 | 5.436055e-04 | 0 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 67 | 5.569127e-04 | 0 |
| HPA | HPA:0150891 | Duodenum; goblet cells[≥Low] | Duodenum; goblet cells[≥Low] | 13 | 5.812030e-04 | 0 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 57 | 6.001627e-04 | 0 |
| HPA | HPA:0401331 | Rectum; mucosal lymphoid cells[≥Low] | Rectum; mucosal lymphoid cells[≥Low] | 15 | 6.069225e-04 | 0 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 64 | 6.572824e-04 | 0 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 64 | 6.572824e-04 | 0 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 48 | 6.589822e-04 | 0 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 64 | 6.667590e-04 | 0 |
| HPA | HPA:0400891 | Rectum; goblet cells[≥Low] | Rectum; goblet cells[≥Low] | 13 | 6.839859e-04 | 0 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 61 | 7.066948e-04 | 0 |
| HPA | HPA:0030893 | Appendix; goblet cells[High] | Appendix; goblet cells[High] | 9 | 7.119962e-04 | 0 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 69 | 7.136850e-04 | 0 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 68 | 7.340948e-04 | 0 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 68 | 7.340948e-04 | 0 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 68 | 7.556573e-04 | 0 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 68 | 7.556573e-04 | 0 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 66 | 7.606913e-04 | 0 |
| HPA | HPA:0151303 | Duodenum; enterocytes[High] | Duodenum; enterocytes[High] | 10 | 7.971171e-04 | 0 |
| HPA | HPA:0461452 | Skin 1; hair follicles[≥Medium] | Skin 1; hair follicles[≥Medium] | 11 | 8.712250e-04 | 0 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 53 | 9.007269e-04 | 0 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 35 | 9.013155e-04 | 0 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 13 | 1.068441e-03 | 0 |
| HPA | HPA:0481301 | Small intestine; enterocytes[≥Low] | Small intestine; enterocytes[≥Low] | 15 | 1.100189e-03 | 0 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 46 | 1.135498e-03 | 0 |
| HPA | HPA:0461451 | Skin 1; hair follicles[≥Low] | Skin 1; hair follicles[≥Low] | 12 | 1.260301e-03 | 0 |
| HPA | HPA:0510701 | Soft tissue 2; peripheral nerve[≥Low] | Soft tissue 2; peripheral nerve[≥Low] | 40 | 1.271748e-03 | 0 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 59 | 1.272920e-03 | 0 |
| HPA | HPA:0530713 | Spleen; cells in red pulp[High] | Spleen; cells in red pulp[High] | 18 | 1.348479e-03 | 0 |
| HPA | HPA:0030443 | Appendix; non-germinal center cells[High] | Appendix; non-germinal center cells[High] | 7 | 1.375750e-03 | 0 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 57 | 1.407902e-03 | 0 |
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 29 | 1.466944e-03 | 0 |
| HPA | HPA:0151352 | Duodenum; paneth cells[≥Medium] | Duodenum; paneth cells[≥Medium] | 10 | 1.540469e-03 | 0 |
| HPA | HPA:0570000 | Testis | Testis | 73 | 1.556704e-03 | 0 |
| HPA | HPA:0270000 | Kidney | Kidney | 70 | 1.711202e-03 | 0 |
| HPA | HPA:0151292 | Duodenum; endocrine cells[≥Medium] | Duodenum; endocrine cells[≥Medium] | 13 | 1.800286e-03 | 0 |
| HPA | HPA:0090183 | Cerebellum; cells in granular layer[High] | Cerebellum; cells in granular layer[High] | 17 | 1.828193e-03 | 0 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 38 | 1.923076e-03 | 0 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 37 | 2.011036e-03 | 0 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 56 | 2.307767e-03 | 0 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 57 | 2.353160e-03 | 0 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 55 | 2.516104e-03 | 0 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 55 | 2.516104e-03 | 0 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 50 | 2.553277e-03 | 0 |
| HPA | HPA:0340453 | Ovary; follicle cells[High] | Ovary; follicle cells[High] | 15 | 2.970317e-03 | 0 |
| HPA | HPA:0500701 | Soft tissue 1; peripheral nerve[≥Low] | Soft tissue 1; peripheral nerve[≥Low] | 36 | 3.039442e-03 | 0 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 25 | 3.338381e-03 | 0 |
| HPA | HPA:0360053 | Parathyroid gland; glandular cells[High] | Parathyroid gland; glandular cells[High] | 25 | 3.376570e-03 | 0 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 42 | 3.476655e-03 | 0 |
| HPA | HPA:0151353 | Duodenum; paneth cells[High] | Duodenum; paneth cells[High] | 8 | 3.581086e-03 | 0 |
| HPA | HPA:0151351 | Duodenum; paneth cells[≥Low] | Duodenum; paneth cells[≥Low] | 10 | 3.639588e-03 | 0 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 62 | 3.850375e-03 | 0 |
| HPA | HPA:0100203 | Cerebral cortex; endothelial cells[High] | Cerebral cortex; endothelial cells[High] | 12 | 4.794800e-03 | 0 |
| HPA | HPA:0031293 | Appendix; endocrine cells[High] | Appendix; endocrine cells[High] | 9 | 4.824581e-03 | 0 |
| HPA | HPA:0570761 | Testis; pachytene spermatocytes[≥Low] | Testis; pachytene spermatocytes[≥Low] | 32 | 4.913671e-03 | 0 |
| HPA | HPA:0460663 | Skin 1; keratinocytes[High] | Skin 1; keratinocytes[High] | 15 | 5.011597e-03 | 0 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 56 | 6.078204e-03 | 0 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 57 | 6.169874e-03 | 0 |
| HPA | HPA:0151293 | Duodenum; endocrine cells[High] | Duodenum; endocrine cells[High] | 10 | 7.634375e-03 | 0 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 50 | 7.879069e-03 | 0 |
| HPA | HPA:0090181 | Cerebellum; cells in granular layer[≥Low] | Cerebellum; cells in granular layer[≥Low] | 48 | 7.966559e-03 | 0 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 52 | 8.329208e-03 | 0 |
| HPA | HPA:0530723 | Spleen; cells in white pulp[High] | Spleen; cells in white pulp[High] | 17 | 8.422902e-03 | 0 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 45 | 8.483258e-03 | 0 |
| HPA | HPA:0340451 | Ovary; follicle cells[≥Low] | Ovary; follicle cells[≥Low] | 39 | 8.582135e-03 | 0 |
| HPA | HPA:0090182 | Cerebellum; cells in granular layer[≥Medium] | Cerebellum; cells in granular layer[≥Medium] | 36 | 9.164935e-03 | 0 |
| HPA | HPA:0570791 | Testis; round or early spermatids[≥Low] | Testis; round or early spermatids[≥Low] | 31 | 9.893758e-03 | 0 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 58 | 1.055784e-02 | 0 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 51 | 1.128867e-02 | 0 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 49 | 1.138970e-02 | 0 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 50 | 1.258343e-02 | 0 |
| HPA | HPA:0100202 | Cerebral cortex; endothelial cells[≥Medium] | Cerebral cortex; endothelial cells[≥Medium] | 32 | 1.446360e-02 | 0 |
| HPA | HPA:0481353 | Small intestine; paneth cells[High] | Small intestine; paneth cells[High] | 7 | 1.489676e-02 | 0 |
| HPA | HPA:0490692 | Smooth muscle; smooth muscle cells[≥Medium] | Smooth muscle; smooth muscle cells[≥Medium] | 37 | 1.562736e-02 | 0 |
| HPA | HPA:0270363 | Kidney; cells in tubules[High] | Kidney; cells in tubules[High] | 29 | 1.793042e-02 | 0 |
| HPA | HPA:0530712 | Spleen; cells in red pulp[≥Medium] | Spleen; cells in red pulp[≥Medium] | 37 | 1.839625e-02 | 0 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 27 | 1.859611e-02 | 0 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 44 | 2.138121e-02 | 0 |
| HPA | HPA:0471452 | Skin 2; hair follicles[≥Medium] | Skin 2; hair follicles[≥Medium] | 7 | 2.238782e-02 | 0 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 49 | 2.557292e-02 | 0 |
| HPA | HPA:0461482 | Skin 1; sebaceous glands[≥Medium] | Skin 1; sebaceous glands[≥Medium] | 7 | 2.714819e-02 | 0 |
| HPA | HPA:0570802 | Testis; sertoli cells[≥Medium] | Testis; sertoli cells[≥Medium] | 26 | 2.769719e-02 | 0 |
| HPA | HPA:0481352 | Small intestine; paneth cells[≥Medium] | Small intestine; paneth cells[≥Medium] | 8 | 3.071142e-02 | 0 |
| HPA | HPA:0030432 | Appendix; germinal center cells[≥Medium] | Appendix; germinal center cells[≥Medium] | 8 | 3.071142e-02 | 0 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 43 | 3.197983e-02 | 0 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 58 | 3.509774e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 33 | 1.100020e-17 | 0 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 33 | 1.020118e-11 | 0 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 28 | 5.089729e-09 | 0 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 19 | 6.261848e-06 | 0 |
| MIRNA | MIRNA:hsa-mir-30c-5p | hsa-mir-30c-5p | hsa-mir-30c-5p | 15 | 1.184575e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-30a-5p | hsa-mir-30a-5p | hsa-mir-30a-5p | 17 | 2.623532e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 13 | 4.019728e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 25 | 2.247136e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 14 | 5.097157e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-15b-5p | hsa-mir-15b-5p | hsa-mir-15b-5p | 15 | 1.547225e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-149-5p | hsa-mir-149-5p | hsa-mir-149-5p | 11 | 1.600231e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-15a-5p | hsa-mir-15a-5p | hsa-mir-15a-5p | 14 | 3.553908e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-125b-5p | hsa-mir-125b-5p | hsa-mir-125b-5p | 11 | 4.476952e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-3617 | hsa-mir-3617 | hsa-mir-3617 | 19 | 5.370866e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-548z | hsa-mir-548z | hsa-mir-548z | 24 | 5.672503e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-548ac | hsa-mir-548ac | hsa-mir-548ac | 24 | 5.672503e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-548d-3p | hsa-mir-548d-3p | hsa-mir-548d-3p | 24 | 5.939454e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-26a-5p | hsa-mir-26a-5p | hsa-mir-26a-5p | 11 | 6.004420e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-17-3p | hsa-mir-17-3p | hsa-mir-17-3p | 7 | 6.710973e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-25-3p | hsa-mir-25-3p | hsa-mir-25-3p | 11 | 7.155493e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-641 | hsa-mir-641 | hsa-mir-641 | 19 | 9.372062e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-3148 | hsa-mir-3148 | hsa-mir-3148 | 26 | 9.878904e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-378a-3p | hsa-mir-378a-3p | hsa-mir-378a-3p | 7 | 1.072188e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-222-3p | hsa-mir-222-3p | hsa-mir-222-3p | 10 | 1.194905e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-1296-5p | hsa-mir-1296-5p | hsa-mir-1296-5p | 6 | 1.515108e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3163 | hsa-mir-3163 | hsa-mir-3163 | 28 | 1.535819e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-580 | hsa-mir-580 | hsa-mir-580 | 17 | 1.752055e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-296-3p | hsa-mir-296-3p | hsa-mir-296-3p | 14 | 1.794235e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3662 | hsa-mir-3662 | hsa-mir-3662 | 26 | 1.987195e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-17-5p | hsa-mir-17-5p | hsa-mir-17-5p | 17 | 2.059549e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-375 | hsa-mir-375 | hsa-mir-375 | 16 | 2.459581e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-496 | hsa-mir-496 | hsa-mir-496 | 12 | 2.837620e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-1301-3p | hsa-mir-1301-3p | hsa-mir-1301-3p | 7 | 3.049501e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-330-3p | hsa-mir-330-3p | hsa-mir-330-3p | 20 | 3.316731e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4694-3p | hsa-mir-4694-3p | hsa-mir-4694-3p | 18 | 3.508307e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-10a-5p | hsa-mir-10a-5p | hsa-mir-10a-5p | 10 | 3.626800e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-581 | hsa-mir-581 | hsa-mir-581 | 12 | 3.665088e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-484 | hsa-mir-484 | hsa-mir-484 | 23 | 4.142742e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-6859-5p | hsa-mir-6859-5p | hsa-mir-6859-5p | 6 | 4.720220e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-3371556 | Cellular response to heat stress | Cellular response to heat stress | 15 | 1.037942e-14 | 0 |
| REAC | REAC:R-HSA-3371511 | HSF1 activation | HSF1 activation | 8 | 9.039437e-13 | 0 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 41 | 1.698260e-10 | 0 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 31 | 5.682028e-10 | 0 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 27 | 8.468332e-10 | 0 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 27 | 1.277882e-09 | 0 |
| REAC | REAC:R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | Regulation of HSF1-mediated heat shock response | 10 | 1.341617e-08 | 0 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 25 | 2.711326e-07 | 0 |
| REAC | REAC:R-HSA-9613829 | Chaperone Mediated Autophagy | Chaperone Mediated Autophagy | 6 | 3.013807e-06 | 0 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 28 | 3.610751e-06 | 0 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 30 | 2.098166e-05 | 0 |
| REAC | REAC:R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translation | Respiratory syncytial virus (RSV) genome replication, transcription and translation | 5 | 2.736654e-05 | 0 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 28 | 2.812098e-05 | 0 |
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 11 | 6.839297e-05 | 0 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 11 | 9.653573e-05 | 0 |
| REAC | REAC:R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins | SUMO E3 ligases SUMOylate target proteins | 10 | 1.428433e-04 | 0 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 34 | 1.592113e-04 | 0 |
| REAC | REAC:R-HSA-2990846 | SUMOylation | SUMOylation | 10 | 1.963263e-04 | 0 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 9 | 2.476998e-04 | 0 |
| REAC | REAC:R-HSA-9646399 | Aggrephagy | Aggrephagy | 6 | 2.519647e-04 | 0 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 18 | 3.656972e-04 | 0 |
| REAC | REAC:R-HSA-9612973 | Autophagy | Autophagy | 9 | 4.190550e-04 | 0 |
| REAC | REAC:R-HSA-9663891 | Selective autophagy | Selective autophagy | 7 | 6.079365e-04 | 0 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 18 | 6.970182e-04 | 0 |
| REAC | REAC:R-HSA-5633007 | Regulation of TP53 Activity | Regulation of TP53 Activity | 9 | 7.603708e-04 | 0 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 10 | 8.163895e-04 | 0 |
| REAC | REAC:R-HSA-3371568 | Attenuation phase | Attenuation phase | 4 | 9.388509e-04 | 0 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 37 | 9.776878e-04 | 0 |
| REAC | REAC:R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | Regulation of mRNA stability by proteins that bind AU-rich elements | 7 | 9.939531e-04 | 0 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 14 | 1.004499e-03 | 0 |
| REAC | REAC:R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | 6 | 1.204058e-03 | 0 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 11 | 1.503572e-03 | 0 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 26 | 1.597602e-03 | 0 |
| REAC | REAC:R-HSA-6804757 | Regulation of TP53 Degradation | Regulation of TP53 Degradation | 5 | 2.114359e-03 | 0 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 32 | 2.159362e-03 | 0 |
| REAC | REAC:R-HSA-8876725 | Protein methylation | Protein methylation | 4 | 2.196446e-03 | 0 |
| REAC | REAC:R-HSA-449147 | Signaling by Interleukins | Signaling by Interleukins | 14 | 2.256889e-03 | 0 |
| REAC | REAC:R-HSA-6806003 | Regulation of TP53 Expression and Degradation | Regulation of TP53 Expression and Degradation | 5 | 2.431242e-03 | 0 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 15 | 2.439617e-03 | 0 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 18 | 2.636013e-03 | 0 |
| REAC | REAC:R-HSA-5336415 | Uptake and function of diphtheria toxin | Uptake and function of diphtheria toxin | 3 | 2.859608e-03 | 0 |
| REAC | REAC:R-HSA-9824439 | Bacterial Infection Pathways | Bacterial Infection Pathways | 6 | 2.866190e-03 | 0 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 11 | 3.132863e-03 | 0 |
| REAC | REAC:R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 5 | 3.175993e-03 | 0 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 12 | 3.197072e-03 | 0 |
| REAC | REAC:R-HSA-110320 | Translesion Synthesis by POLH | Translesion Synthesis by POLH | 4 | 3.538748e-03 | 0 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 9 | 4.017424e-03 | 0 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 9 | 4.360358e-03 | 0 |
| REAC | REAC:R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | Deactivation of the beta-catenin transactivating complex | 5 | 4.615257e-03 | 0 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 13 | 7.641405e-03 | 0 |
| REAC | REAC:R-HSA-9818749 | Regulation of NFE2L2 gene expression | Regulation of NFE2L2 gene expression | 3 | 7.925306e-03 | 0 |
| REAC | REAC:R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | Respiratory Syncytial Virus Infection Pathway | 7 | 8.597649e-03 | 0 |
| REAC | REAC:R-HSA-73893 | DNA Damage Bypass | DNA Damage Bypass | 5 | 8.986978e-03 | 0 |
| REAC | REAC:R-HSA-3371571 | HSF1-dependent transactivation | HSF1-dependent transactivation | 4 | 9.443830e-03 | 0 |
| REAC | REAC:R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4 | 1.118233e-02 | 0 |
| REAC | REAC:R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | Constitutive Signaling by AKT1 E17K in Cancer | 4 | 1.118233e-02 | 0 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 7 | 1.123127e-02 | 0 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 6 | 1.240160e-02 | 0 |
| REAC | REAC:R-HSA-5218920 | VEGFR2 mediated vascular permeability | VEGFR2 mediated vascular permeability | 4 | 1.534784e-02 | 0 |
| REAC | REAC:R-HSA-1632852 | Macroautophagy | Macroautophagy | 7 | 1.850706e-02 | 0 |
| REAC | REAC:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Regulation of TP53 Activity through Phosphorylation | 6 | 1.944161e-02 | 0 |
| REAC | REAC:R-HSA-9834752 | Respiratory syncytial virus genome replication | Respiratory syncytial virus genome replication | 2 | 2.101898e-02 | 0 |
| REAC | REAC:R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | Assembly and release of respiratory syncytial virus (RSV) virions | 2 | 2.101898e-02 | 0 |
| REAC | REAC:R-HSA-69473 | G2/M DNA damage checkpoint | G2/M DNA damage checkpoint | 6 | 2.195193e-02 | 0 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 6 | 2.330087e-02 | 0 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 4 | 2.358279e-02 | 0 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 20 | 2.457618e-02 | 0 |
| REAC | REAC:R-HSA-5689877 | Josephin domain DUBs | Josephin domain DUBs | 3 | 3.050431e-02 | 0 |
| REAC | REAC:R-HSA-9614399 | Regulation of localization of FOXO transcription factors | Regulation of localization of FOXO transcription factors | 3 | 3.050431e-02 | 0 |
| REAC | REAC:R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 3 | 3.050431e-02 | 0 |
| REAC | REAC:R-HSA-5656169 | Termination of translesion DNA synthesis | Termination of translesion DNA synthesis | 4 | 3.061379e-02 | 0 |
| REAC | REAC:R-HSA-73894 | DNA Repair | DNA Repair | 10 | 4.366071e-02 | 0 |
| REAC | REAC:R-HSA-9706574 | RHOBTB GTPase Cycle | RHOBTB GTPase Cycle | 4 | 4.386295e-02 | 0 |
| REAC | REAC:R-HSA-5696398 | Nucleotide Excision Repair | Nucleotide Excision Repair | 6 | 4.530194e-02 | 0 |
| REAC | REAC:R-HSA-73933 | Resolution of Abasic Sites (AP sites) | Resolution of Abasic Sites (AP sites) | 4 | 4.908152e-02 | 0 |
| REAC | REAC:R-HSA-69166 | Removal of the Flap Intermediate | Removal of the Flap Intermediate | 3 | 4.995728e-02 | 0 |
| REAC | REAC:R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3 | 4.995728e-02 | 0 |
| REAC | REAC:R-HSA-198323 | AKT phosphorylates targets in the cytosol | AKT phosphorylates targets in the cytosol | 3 | 4.995728e-02 | 0 |
| REAC | REAC:R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3 | 4.995728e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 16 | 2.675254e-13 | 0 |
| WP | WP:WP411 | mRNA processing | mRNA processing | 11 | 2.124738e-06 | 0 |
| WP | WP:WP3594 | Circadian rhythm genes | Circadian rhythm genes | 12 | 2.942087e-05 | 0 |
| WP | WP:WP5475 | Hallmark of cancer sustaining proliferative signaling | Hallmark of cancer sustaining proliferative signaling | 9 | 3.203731e-05 | 0 |
| WP | WP:WP2359 | Parkin ubiquitin proteasomal system pathway | Parkin ubiquitin proteasomal system pathway | 8 | 3.255919e-05 | 0 |
| WP | WP:WP3981 | miRNA regulation of prostate cancer signaling | miRNA regulation of prostate cancer signaling | 6 | 4.430056e-05 | 0 |
| WP | WP:WP5353 | Macrophage stimulating protein MSP signaling | Macrophage stimulating protein MSP signaling | 9 | 7.413788e-05 | 0 |
| WP | WP:WP4016 | DNA IR damage and cellular response via ATR | DNA IR damage and cellular response via ATR | 8 | 9.164485e-05 | 0 |
| WP | WP:WP4754 | IL18 signaling | IL18 signaling | 7 | 9.669352e-05 | 0 |
| WP | WP:WP4659 | Gastrin signaling | Gastrin signaling | 9 | 1.177004e-04 | 0 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 16 | 1.569760e-04 | 0 |
| WP | WP:WP2036 | TNF related weak inducer of apoptosis TWEAK signaling | TNF related weak inducer of apoptosis TWEAK signaling | 6 | 1.580831e-04 | 0 |
| WP | WP:WP706 | Sudden infant death syndrome SIDS susceptibility pathways | Sudden infant death syndrome SIDS susceptibility pathways | 10 | 2.238390e-04 | 0 |
| WP | WP:WP2355 | Corticotropin releasing hormone signaling | Corticotropin releasing hormone signaling | 8 | 2.254512e-04 | 0 |
| WP | WP:WP5049 | Glycolysis in senescence | Glycolysis in senescence | 4 | 3.201104e-04 | 0 |
| WP | WP:WP3303 | RAC1 PAK1 p38 MMP2 pathway | RAC1 PAK1 p38 MMP2 pathway | 7 | 3.710788e-04 | 0 |
| WP | WP:WP2380 | Brain derived neurotrophic factor BDNF signaling | Brain derived neurotrophic factor BDNF signaling | 9 | 5.518672e-04 | 0 |
| WP | WP:WP2037 | Prolactin signaling | Prolactin signaling | 7 | 6.600214e-04 | 0 |
| WP | WP:WP710 | DNA damage response only ATM dependent | DNA damage response only ATM dependent | 8 | 8.861712e-04 | 0 |
| WP | WP:WP3286 | Copper homeostasis | Copper homeostasis | 6 | 9.407428e-04 | 0 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 8 | 1.159995e-03 | 0 |
| WP | WP:WP1984 | Integrated breast cancer pathway | Integrated breast cancer pathway | 9 | 1.297408e-03 | 0 |
| WP | WP:WP3959 | DNA IR double strand breaks and cellular response via ATM | DNA IR double strand breaks and cellular response via ATM | 6 | 1.472120e-03 | 0 |
| WP | WP:WP2272 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 6 | 1.472120e-03 | 0 |
| WP | WP:WP138 | Androgen receptor signaling | Androgen receptor signaling | 7 | 1.673925e-03 | 0 |
| WP | WP:WP382 | MAPK signaling | MAPK signaling | 11 | 1.708343e-03 | 0 |
| WP | WP:WP5381 | Smith Magenis and Potocki Lupski syndrome copy number variation | Smith Magenis and Potocki Lupski syndrome copy number variation | 9 | 1.870737e-03 | 0 |
| WP | WP:WP254 | Apoptosis | Apoptosis | 7 | 1.953681e-03 | 0 |
| WP | WP:WP5098 | T cell activation SARS CoV 2 | T cell activation SARS CoV 2 | 7 | 2.107462e-03 | 0 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 7 | 2.271144e-03 | 0 |
| WP | WP:WP3850 | Factors and pathways affecting insulin like growth factor IGF1 Akt signaling | Factors and pathways affecting insulin like growth factor IGF1 Akt signaling | 5 | 2.613735e-03 | 0 |
| WP | WP:WP4155 | Endometrial cancer | Endometrial cancer | 6 | 3.260834e-03 | 0 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 6 | 3.572853e-03 | 0 |
| WP | WP:WP5331 | Autophagy in pancreatic ductal adenocarcinoma | Autophagy in pancreatic ductal adenocarcinoma | 4 | 4.421758e-03 | 0 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 6 | 5.514609e-03 | 0 |
| WP | WP:WP5158 | Urotensin II mediated signaling | Urotensin II mediated signaling | 6 | 5.514609e-03 | 0 |
| WP | WP:WP5294 | Sildenafil treatment | Sildenafil treatment | 4 | 6.586222e-03 | 0 |
| WP | WP:WP4141 | PI3K AKT mTOR vitamin D3 signaling | PI3K AKT mTOR vitamin D3 signaling | 4 | 6.586222e-03 | 0 |
| WP | WP:WP5046 | NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence | NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence | 4 | 6.586222e-03 | 0 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 6 | 7.613037e-03 | 0 |
| WP | WP:WP712 | Estrogen signaling | Estrogen signaling | 4 | 7.919029e-03 | 0 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 6 | 8.226538e-03 | 0 |
| WP | WP:WP4666 | Hepatitis B infection | Hepatitis B infection | 8 | 1.005258e-02 | 0 |
| WP | WP:WP3658 | Wnt beta catenin signaling in leukemia | Wnt beta catenin signaling in leukemia | 4 | 1.310123e-02 | 0 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 7 | 1.572714e-02 | 0 |
| WP | WP:WP4747 | Netrin UNC5B signaling | Netrin UNC5B signaling | 5 | 1.612272e-02 | 0 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 10 | 1.665122e-02 | 0 |
| WP | WP:WP2864 | Apoptosis related network due to altered Notch3 in ovarian cancer | Apoptosis related network due to altered Notch3 in ovarian cancer | 5 | 1.767900e-02 | 0 |
| WP | WP:WP3875 | ATR signaling | ATR signaling | 3 | 1.859581e-02 | 0 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 10 | 1.950200e-02 | 0 |
| WP | WP:WP3646 | Hepatitis C and hepatocellular carcinoma | Hepatitis C and hepatocellular carcinoma | 5 | 2.304745e-02 | 0 |
| WP | WP:WP673 | ErbB signaling | ErbB signaling | 6 | 2.321581e-02 | 0 |
| WP | WP:WP23 | B cell receptor signaling | B cell receptor signaling | 6 | 2.789195e-02 | 0 |
| WP | WP:WP2839 | Hair follicle development organogenesis stage 2 of 3 | Hair follicle development organogenesis stage 2 of 3 | 4 | 3.026089e-02 | 0 |
| WP | WP:WP2112 | IL17 signaling | IL17 signaling | 4 | 3.026089e-02 | 0 |
| WP | WP:WP4628 | Aerobic glycolysis augmented | Aerobic glycolysis augmented | 3 | 3.182080e-02 | 0 |
| WP | WP:WP4258 | lncRNA in canonical Wnt signaling and colorectal cancer | lncRNA in canonical Wnt signaling and colorectal cancer | 6 | 3.731510e-02 | 0 |
| WP | WP:WP5531 | AKT signaling and ARTD family members | AKT signaling and ARTD family members | 4 | 3.850263e-02 | 0 |
| WP | WP:WP399 | Wnt signaling and pluripotency | Wnt signaling and pluripotency | 6 | 4.407300e-02 | 0 |
| WP | WP:WP2064 | Neural crest differentiation | Neural crest differentiation | 6 | 4.652780e-02 | 0 |
| WP | WP:WP3873 | RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis | RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis | 3 | 4.997747e-02 | 0 |
| WP | WP:WP5529 | Wnt Beta catenin signaling and ARTD family members | Wnt Beta catenin signaling and ARTD family members | 3 | 4.997747e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 10 | 3.615014e-07 | 0 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 13 | 4.718509e-07 | 0 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | Lipid and atherosclerosis | 13 | 1.006985e-06 | 0 |
| KEGG | KEGG:05134 | Legionellosis | Legionellosis | 8 | 1.024343e-06 | 0 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 9 | 3.111906e-04 | 0 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 11 | 3.516841e-04 | 0 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 9 | 3.643928e-04 | 0 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 9 | 4.473628e-04 | 0 |
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 6 | 5.244240e-04 | 0 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 9 | 6.020448e-04 | 0 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | IL-17 signaling pathway | 7 | 6.811801e-04 | 0 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 8 | 9.611362e-04 | 0 |
| KEGG | KEGG:05162 | Measles | Measles | 8 | 1.129274e-03 | 0 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | Fluid shear stress and atherosclerosis | 8 | 1.129274e-03 | 0 |
| KEGG | KEGG:04612 | Antigen processing and presentation | Antigen processing and presentation | 6 | 1.447997e-03 | 0 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 14 | 1.676999e-03 | 0 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 9 | 2.252162e-03 | 0 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 6 | 2.525462e-03 | 0 |
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 8 | 2.876862e-03 | 0 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | Chemical carcinogenesis - receptor activation | 9 | 3.713905e-03 | 0 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | Thyroid hormone signaling pathway | 7 | 4.075861e-03 | 0 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 9 | 4.789335e-03 | 0 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 6 | 5.095930e-03 | 0 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 9 | 5.709307e-03 | 0 |
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 8 | 5.976070e-03 | 0 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 7 | 6.756484e-03 | 0 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | Estrogen signaling pathway | 7 | 8.556805e-03 | 0 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 11 | 9.683393e-03 | 0 |
| KEGG | KEGG:04010 | MAPK signaling pathway | MAPK signaling pathway | 10 | 1.124937e-02 | 0 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | Transcriptional misregulation in cancer | 8 | 1.188133e-02 | 0 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 9 | 1.209643e-02 | 0 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 8 | 1.276291e-02 | 0 |
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | Diabetic cardiomyopathy | 8 | 1.684752e-02 | 0 |
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 6 | 1.803001e-02 | 0 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 8 | 1.863265e-02 | 0 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 7 | 2.087370e-02 | 0 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 9 | 2.113302e-02 | 0 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 13 | 2.132070e-02 | 0 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | Neurotrophin signaling pathway | 6 | 2.913429e-02 | 0 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | B cell receptor signaling pathway | 5 | 3.800658e-02 | 0 |
| KEGG | KEGG:04310 | Wnt signaling pathway | Wnt signaling pathway | 7 | 3.896302e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100526 | Neoplasm of the lung | Tumor of the lung. | 8 | 0.000035 | 0 |
| HP | HP:0100606 | Neoplasm of the respiratory system | A tumor (abnormal growth of tissue) of the respiratory system. | 8 | 0.000154 | 0 |
| HP | HP:0025769 | Disordered formal thought process | An abnormality in the dynamic mode, rate, or form of thought processes as recognized from the flow of ideas expressed in speech. Successive thoughts and speech are easily diverted by external stimuli or internal superficial associations. Unable to maintain a constant train of thought and loose themselves in side issues, losing the thread and are unable to recover it. Superficial connections appear to drive the subject matter. | 6 | 0.000457 | 0 |
| HP | HP:0030223 | Perseverative thought | The repetitive production of the same response to different commands. | 5 | 0.000472 | 0 |
| HP | HP:0100728 | Germ cell neoplasia | Germ cell neoplasia | 6 | 0.001330 | 0 |
| HP | HP:0010785 | Gonadal neoplasm | A tumor (abnormal growth of tissue) of a gonad. | 8 | 0.001492 | 0 |
| HP | HP:0100615 | Ovarian neoplasm | A tumor (abnormal growth of tissue) of the ovary. | 7 | 0.001975 | 0 |
| HP | HP:0100314 | Cerebral inclusion bodies | Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain. | 6 | 0.002890 | 0 |
| HP | HP:0010787 | Genital neoplasm | A tumor (abnormal growth of tissue) of the genital system. | 9 | 0.003094 | 0 |
| HP | HP:0011960 | Substantia nigra gliosis | Focal proliferation of glial cells in the substantia nigra. | 4 | 0.003098 | 0 |
| HP | HP:0100315 | Lewy bodies | Lewy bodies | 5 | 0.003429 | 0 |
| HP | HP:0010788 | Testicular neoplasm | The presence of a neoplasm of the testis. | 5 | 0.006693 | 0 |
| HP | HP:0100848 | Neoplasm of the male external genitalia | A tumor (abnormal growth of tissue) of the male external genitalia. | 5 | 0.007800 | 0 |
| HP | HP:0100006 | Neoplasm of the central nervous system | A neoplasm of the central nervous system. | 9 | 0.010815 | 0 |
| HP | HP:0000008 | Abnormal morphology of female internal genitalia | An abnormality of the female internal genitalia. | 14 | 0.012621 | 0 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 10 | 0.013060 | 0 |
| HP | HP:0002362 | Shuffling gait | A type of gait (walking) characterized by by dragging one's feet along or without lifting the feet fully from the ground. | 5 | 0.020154 | 0 |
| HP | HP:0006774 | Ovarian papillary adenocarcinoma | The presence of a papillary adenocarcinoma of the ovary. | 3 | 0.020882 | 0 |
| HP | HP:0004375 | Neoplasm of the nervous system | A tumor (abnormal growth of tissue) of the nervous system. | 9 | 0.022673 | 0 |
| HP | HP:0045007 | Abnormal substantia nigra morphology | A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry. | 4 | 0.030074 | 0 |
| HP | HP:0100705 | Abnormal glial cell morphology | An abnormality of the glia cell. | 8 | 0.030342 | 0 |
| HP | HP:0002442 | Dyscalculia | A specific learning disability involving mathematics and arithmetic. | 4 | 0.043179 | 0 |
| HP | HP:0011793 | Neoplasm by anatomical site | Neoplasm categorized according to the anatomical site of origin of the neoplasm. | 19 | 0.048642 | 0 |
| HP | HP:0004490 | Calvarial hyperostosis | Excessive growth of the calvaria. | 3 | 0.049557 | 0 |
| HP | HP:0025134 | Increased serum estradiol | An elevation above normal limits of the concentration of estradiol in the circulation. | 3 | 0.049557 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1332 | Large Drosha complex | Large Drosha complex | 6 | 0.000133 | 0 |
| CORUM | CORUM:5199 | Kinase maturation complex 1 | Kinase maturation complex 1 | 5 | 0.000946 | 0 |
| CORUM | CORUM:3135 | TLE1 corepressor complex (MASH1 promoter-corepressor complex) | TLE1 corepressor complex (MASH1 promoter-corepressor complex) | 4 | 0.000992 | 0 |
| CORUM | CORUM:1729 | TLE1 corepressor complex (MASH1 promoter-corepressor complex) | TLE1 corepressor complex (MASH1 promoter-corepressor complex) | 4 | 0.002897 | 0 |
| CORUM | CORUM:3082 | DGCR8 multiprotein complex | DGCR8 multiprotein complex | 4 | 0.002897 | 0 |
| CORUM | CORUM:5423 | HSP70-BAG5-PARK2 complex | HSP70-BAG5-PARK2 complex | 3 | 0.003444 | 0 |
| CORUM | CORUM:1335 | SNW1 complex | SNW1 complex | 4 | 0.017599 | 0 |
| CORUM | CORUM:2721 | HCF-1 complex | HCF-1 complex | 4 | 0.023149 | 0 |
| CORUM | CORUM:6412 | AURKA-HDAC6 cilia-disassembly complex | AURKA-HDAC6 cilia-disassembly complex | 2 | 0.049983 | 0 |
| CORUM | CORUM:5229 | RPA complex | RPA complex | 2 | 0.049983 | 0 |
| CORUM | CORUM:5718 | NOS3-HSP90-AKT complex, VEGF induced | NOS3-HSP90-AKT complex, VEGF induced | 2 | 0.049983 | 0 |
| CORUM | CORUM:7180 | p53-MDM2 complex | p53-MDM2 complex | 2 | 0.049983 | 0 |
| CORUM | CORUM:1816 | JUN-TCF4-CTNNB1 complex | JUN-TCF4-CTNNB1 complex | 2 | 0.049983 | 0 |
| CORUM | CORUM:5331 | YY1-MDM2-p53 complex | YY1-MDM2-p53 complex | 2 | 0.049983 | 0 |
| CORUM | CORUM:2156 | YBX1-AKT1 complex | YBX1-AKT1 complex | 2 | 0.049983 | 0 |
| CORUM | CORUM:7284 | GSK3B-HSP90AA1-PKM2 complex | GSK3B-HSP90AA1-PKM2 complex | 2 | 0.049983 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M02090_1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | 50 | 0.000419 | 0 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 66 | 0.000879 | 0 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 77 | 0.001002 | 0 |
| TF | TF:M07039 | Factor: ETF; motif: CCCCGCCCCYN | Factor: ETF; motif: CCCCGCCCCYN | 82 | 0.001140 | 0 |
| TF | TF:M09636_1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | 77 | 0.001969 | 0 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 65 | 0.002982 | 0 |
| TF | TF:M04797 | Factor: Egr-1; motif: CCGCCCMCG | Factor: Egr-1; motif: CCGCCCMCG | 42 | 0.003150 | 0 |
| TF | TF:M08020 | Factor: YY2; motif: NNCCGCCATTW | Factor: YY2; motif: NNCCGCCATTW | 21 | 0.003436 | 0 |
| TF | TF:M11603_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 74 | 0.003488 | 0 |
| TF | TF:M00050 | Factor: E2F; motif: TTTSGCGC | Factor: E2F; motif: TTTSGCGC | 51 | 0.003714 | 0 |
| TF | TF:M11601_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 67 | 0.004445 | 0 |
| TF | TF:M04710_1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | 68 | 0.005845 | 0 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 39 | 0.006392 | 0 |
| TF | TF:M04710 | Factor: CHD2; motif: TCTCGCGAG | Factor: CHD2; motif: TCTCGCGAG | 76 | 0.007318 | 0 |
| TF | TF:M12160 | Factor: KLF15; motif: RCCMCRCCCMCN | Factor: KLF15; motif: RCCMCRCCCMCN | 72 | 0.008268 | 0 |
| TF | TF:M00740 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | 64 | 0.009328 | 0 |
| TF | TF:M09894 | Factor: E2F-4; motif: SNGGGCGGGAANN | Factor: E2F-4; motif: SNGGGCGGGAANN | 81 | 0.009616 | 0 |
| TF | TF:M02036_1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | 42 | 0.010671 | 0 |
| TF | TF:M00986 | Factor: Churchill; motif: CGGGNN | Factor: Churchill; motif: CGGGNN | 76 | 0.014327 | 0 |
| TF | TF:M12554 | Factor: YY2; motif: NNATGGCGGCN | Factor: YY2; motif: NNATGGCGGCN | 27 | 0.015274 | 0 |
| TF | TF:M01199 | Factor: RNF96; motif: BCCCGCRGCC | Factor: RNF96; motif: BCCCGCRGCC | 56 | 0.015497 | 0 |
| TF | TF:M02089 | Factor: E2F-3; motif: GGCGGGN | Factor: E2F-3; motif: GGCGGGN | 73 | 0.015699 | 0 |
| TF | TF:M02036 | Factor: WT1; motif: CGCCCCCNCN | Factor: WT1; motif: CGCCCCCNCN | 61 | 0.016695 | 0 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 78 | 0.017811 | 0 |
| TF | TF:M07084 | Factor: E2F-4; motif: NGGCGGGAARN | Factor: E2F-4; motif: NGGCGGGAARN | 65 | 0.018447 | 0 |
| TF | TF:M04010 | Factor: HSF4; motif: TTCTAGAANNTTC | Factor: HSF4; motif: TTCTAGAANNTTC | 7 | 0.019062 | 0 |
| TF | TF:M12271 | Factor: ZNF339; motif: NNACCGTTANNNN | Factor: ZNF339; motif: NNACCGTTANNNN | 14 | 0.020755 | 0 |
| TF | TF:M09834 | Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN | Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN | 49 | 0.021151 | 0 |
| TF | TF:M04106_1 | Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 | Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 | 55 | 0.025161 | 0 |
| TF | TF:M13366 | Factor: ZBED4; motif: CCCGCYCCGC | Factor: ZBED4; motif: CCCGCYCCGC | 52 | 0.025838 | 0 |
| TF | TF:M12597_1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | 61 | 0.027167 | 0 |
| TF | TF:M12597 | Factor: E2F1; motif: GSGCGGGAAN | Factor: E2F1; motif: GSGCGGGAAN | 75 | 0.031281 | 0 |
| TF | TF:M03962 | Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT | Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT | 65 | 0.031710 | 0 |
| TF | TF:M04691_1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | 63 | 0.031766 | 0 |
| TF | TF:M00333_1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | 70 | 0.032447 | 0 |
| TF | TF:M00243 | Factor: Egr-1; motif: WTGCGTGGGCGK | Factor: Egr-1; motif: WTGCGTGGGCGK | 41 | 0.032753 | 0 |
| TF | TF:M04953 | Factor: Sp1; motif: GGNDGGRGGCGGGG | Factor: Sp1; motif: GGNDGGRGGCGGGG | 56 | 0.032972 | 0 |
| TF | TF:M10436_1 | Factor: YY1; motif: CAANATGGCGGC; match class: 1 | Factor: YY1; motif: CAANATGGCGGC; match class: 1 | 24 | 0.038696 | 0 |
| TF | TF:M09826 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | 67 | 0.044713 | 0 |
| TF | TF:M03925 | Factor: YY2; motif: NCCGCCATNTY | Factor: YY2; motif: NCCGCCATNTY | 37 | 0.044877 | 0 |
| TF | TF:M03924_1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | 32 | 0.045412 | 0 |
| TF | TF:M07354_1 | Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 | Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 | 32 | 0.045666 | 0 |
| TF | TF:M03962_1 | Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT; match class: 1 | Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT; match class: 1 | 46 | 0.048855 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0022626 | cytosolic ribosome | "A ribosome located in the cytosol." [GOC:mtg_sensu] | 28 | 4.596599e-51 | 1 |
| GO:CC | GO:0044391 | ribosomal subunit | "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl] | 28 | 1.517816e-44 | 1 |
| GO:CC | GO:0005840 | ribosome | "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] | 28 | 1.646973e-31 | 1 |
| GO:CC | GO:0022627 | cytosolic small ribosomal subunit | "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 15 | 1.455854e-28 | 1 |
| GO:CC | GO:0015935 | small ribosomal subunit | "The smaller of the two subunits of a ribosome." [GOC:mah] | 15 | 4.002059e-24 | 1 |
| GO:CC | GO:0022625 | cytosolic large ribosomal subunit | "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 13 | 9.134592e-22 | 1 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 19 | 1.671818e-18 | 1 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 19 | 2.590931e-18 | 1 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 33 | 1.087498e-17 | 1 |
| GO:CC | GO:0015934 | large ribosomal subunit | "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] | 13 | 2.506927e-17 | 1 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 42 | 7.427306e-15 | 1 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 42 | 7.472039e-15 | 1 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 38 | 3.107518e-13 | 1 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 19 | 2.180852e-12 | 1 |
| GO:CC | GO:0030684 | preribosome | "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] | 10 | 4.715099e-12 | 1 |
| GO:CC | GO:0032040 | small-subunit processome | "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] | 9 | 7.968792e-12 | 1 |
| GO:CC | GO:0005730 | nucleolus | "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] | 24 | 3.046929e-11 | 1 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 35 | 3.523156e-10 | 1 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 23 | 1.630719e-08 | 1 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 36 | 1.673642e-08 | 1 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 36 | 1.673642e-08 | 1 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 36 | 1.673642e-08 | 1 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 29 | 4.236114e-08 | 1 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 37 | 5.629830e-07 | 1 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 18 | 6.982823e-07 | 1 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 40 | 4.968559e-06 | 1 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 43 | 3.740691e-05 | 1 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 47 | 8.154014e-05 | 1 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 7 | 2.661033e-04 | 1 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 7 | 4.270069e-04 | 1 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 47 | 7.700545e-04 | 1 |
| GO:CC | GO:0005791 | rough endoplasmic reticulum | "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] | 4 | 1.994841e-03 | 1 |
| GO:CC | GO:0014069 | postsynaptic density | "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density] | 7 | 2.259661e-03 | 1 |
| GO:CC | GO:0032279 | asymmetric synapse | "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] | 7 | 3.001870e-03 | 1 |
| GO:CC | GO:0099572 | postsynaptic specialization | "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028] | 7 | 4.343074e-03 | 1 |
| GO:CC | GO:0098984 | neuron to neuron synapse | "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos] | 7 | 5.515688e-03 | 1 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 47 | 1.169976e-02 | 1 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 43 | 1.502219e-02 | 1 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 14 | 1.897391e-02 | 1 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 14 | 2.211391e-02 | 1 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 14 | 2.222600e-02 | 1 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 14 | 2.222600e-02 | 1 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 44 | 3.514494e-02 | 1 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 8 | 4.942230e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | SRP-dependent cotranslational protein targeting to membrane | 30 | 1.026040e-50 | 1 |
| REAC | REAC:R-HSA-156902 | Peptide chain elongation | Peptide chain elongation | 28 | 6.854370e-49 | 1 |
| REAC | REAC:R-HSA-192823 | Viral mRNA Translation | Viral mRNA Translation | 28 | 6.854370e-49 | 1 |
| REAC | REAC:R-HSA-156842 | Eukaryotic Translation Elongation | Eukaryotic Translation Elongation | 28 | 2.887918e-48 | 1 |
| REAC | REAC:R-HSA-2408557 | Selenocysteine synthesis | Selenocysteine synthesis | 28 | 2.887918e-48 | 1 |
| REAC | REAC:R-HSA-72764 | Eukaryotic Translation Termination | Eukaryotic Translation Termination | 28 | 2.887918e-48 | 1 |
| REAC | REAC:R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 28 | 5.768638e-48 | 1 |
| REAC | REAC:R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Response of EIF2AK4 (GCN2) to amino acid deficiency | 28 | 4.166451e-47 | 1 |
| REAC | REAC:R-HSA-72689 | Formation of a pool of free 40S subunits | Formation of a pool of free 40S subunits | 28 | 4.166451e-47 | 1 |
| REAC | REAC:R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | L13a-mediated translational silencing of Ceruloplasmin expression | 28 | 8.449829e-46 | 1 |
| REAC | REAC:R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | GTP hydrolysis and joining of the 60S ribosomal subunit | 28 | 1.122136e-45 | 1 |
| REAC | REAC:R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 28 | 2.583564e-45 | 1 |
| REAC | REAC:R-HSA-927802 | Nonsense-Mediated Decay (NMD) | Nonsense-Mediated Decay (NMD) | 28 | 2.583564e-45 | 1 |
| REAC | REAC:R-HSA-2408522 | Selenoamino acid metabolism | Selenoamino acid metabolism | 28 | 3.392758e-45 | 1 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 28 | 7.563182e-45 | 1 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 28 | 7.563182e-45 | 1 |
| REAC | REAC:R-HSA-168273 | Influenza Viral RNA Transcription and Replication | Influenza Viral RNA Transcription and Replication | 28 | 1.907509e-43 | 1 |
| REAC | REAC:R-HSA-168255 | Influenza Infection | Influenza Infection | 28 | 1.766493e-41 | 1 |
| REAC | REAC:R-HSA-9711097 | Cellular response to starvation | Cellular response to starvation | 28 | 3.187668e-41 | 1 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 28 | 4.288125e-40 | 1 |
| REAC | REAC:R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Major pathway of rRNA processing in the nucleolus and cytosol | 28 | 2.819207e-39 | 1 |
| REAC | REAC:R-HSA-8868773 | rRNA processing in the nucleus and cytosol | rRNA processing in the nucleus and cytosol | 28 | 1.406296e-38 | 1 |
| REAC | REAC:R-HSA-72312 | rRNA processing | rRNA processing | 28 | 6.420370e-38 | 1 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 30 | 3.024450e-37 | 1 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 28 | 5.410605e-37 | 1 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 28 | 1.769226e-30 | 1 |
| REAC | REAC:R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | SARS-CoV-1 modulates host translation machinery | 15 | 4.412665e-26 | 1 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 28 | 1.642936e-25 | 1 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 30 | 1.949681e-25 | 1 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 28 | 5.817350e-25 | 1 |
| REAC | REAC:R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | SARS-CoV-2 modulates host translation machinery | 15 | 1.458244e-23 | 1 |
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 15 | 2.045041e-23 | 1 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 30 | 9.262004e-23 | 1 |
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 15 | 1.793510e-22 | 1 |
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 15 | 1.793510e-22 | 1 |
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 15 | 2.386229e-22 | 1 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 28 | 6.963329e-21 | 1 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 28 | 1.126148e-20 | 1 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 30 | 3.023190e-20 | 1 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 15 | 4.593150e-19 | 1 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 34 | 7.088679e-17 | 1 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 15 | 2.065453e-16 | 1 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 29 | 1.332025e-15 | 1 |
| REAC | REAC:R-HSA-9705683 | SARS-CoV-2-host interactions | SARS-CoV-2-host interactions | 15 | 3.862029e-14 | 1 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 30 | 2.495755e-13 | 1 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 15 | 1.378639e-11 | 1 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 29 | 1.163028e-10 | 1 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 16 | 6.327465e-10 | 1 |
| REAC | REAC:R-HSA-9629569 | Protein hydroxylation | Protein hydroxylation | 4 | 2.716352e-04 | 1 |
| REAC | REAC:R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4 | 2.462081e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP477 | Cytoplasmic ribosomal proteins | Cytoplasmic ribosomal proteins | 28 | 6.251443e-48 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 28 | 1.042238e-44 | 1 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 31 | 3.999481e-31 | 1 |
| GO:BP | GO:0042254 | ribosome biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] | 19 | 1.616165e-19 | 1 |
| GO:BP | GO:0042274 | ribosomal small subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 11 | 6.304004e-13 | 1 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 37 | 6.644300e-13 | 1 |
| GO:BP | GO:0006364 | rRNA processing | "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] | 13 | 2.896151e-12 | 1 |
| GO:BP | GO:0016072 | rRNA metabolic process | "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] | 13 | 2.534772e-11 | 1 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 42 | 1.400108e-07 | 1 |
| GO:BP | GO:0042255 | ribosome assembly | "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428] | 7 | 1.466889e-07 | 1 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 42 | 7.641921e-07 | 1 |
| GO:BP | GO:0022613 | ribonucleoprotein complex biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] | 19 | 8.325616e-06 | 1 |
| GO:BP | GO:0042273 | ribosomal large subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 6 | 1.757904e-05 | 1 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 42 | 3.375154e-05 | 1 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 10 | 5.061416e-05 | 1 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 44 | 5.119978e-05 | 1 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 44 | 1.348195e-04 | 1 |
| GO:BP | GO:0000027 | ribosomal large subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428] | 4 | 3.755049e-04 | 1 |
| GO:BP | GO:0034101 | erythrocyte homeostasis | "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] | 6 | 1.489508e-03 | 1 |
| GO:BP | GO:0002262 | myeloid cell homeostasis | "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] | 6 | 5.000329e-03 | 1 |
| GO:BP | GO:0000028 | ribosomal small subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl, PMID:30467428] | 3 | 1.390497e-02 | 1 |
| GO:BP | GO:0048872 | homeostasis of number of cells | "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] | 7 | 1.399933e-02 | 1 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 44 | 2.783740e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03010 | Ribosome | Ribosome | 28 | 3.642746e-40 | 1 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | Coronavirus disease - COVID-19 | 28 | 8.606612e-35 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:306 | Ribosome, cytoplasmic | Ribosome, cytoplasmic | 26 | 4.166399e-36 | 1 |
| CORUM | CORUM:3055 | Nop56p-associated pre-rRNA complex | Nop56p-associated pre-rRNA complex | 24 | 7.882039e-29 | 1 |
| CORUM | CORUM:338 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 14 | 1.746691e-19 | 1 |
| CORUM | CORUM:305 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 14 | 5.905886e-19 | 1 |
| CORUM | CORUM:308 | 60S ribosomal subunit, cytoplasmic | 60S ribosomal subunit, cytoplasmic | 12 | 7.651298e-13 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003735 | structural constituent of ribosome | "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] | 28 | 4.503759e-32 | 1 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 42 | 1.294249e-26 | 1 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 28 | 3.724310e-21 | 1 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 43 | 5.825861e-18 | 1 |
| GO:MF | GO:0019843 | rRNA binding | "Binding to a ribosomal RNA." [GOC:jl] | 8 | 1.363343e-09 | 1 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 7 | 1.350053e-02 | 1 |
| GO:MF | GO:0070180 | large ribosomal subunit rRNA binding | "Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh] | 2 | 2.386954e-02 | 1 |
| GO:MF | GO:0055106 | ubiquitin-protein transferase regulator activity | "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] | 3 | 2.769053e-02 | 1 |
| GO:MF | GO:0008312 | 7S RNA binding | "Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418] | 2 | 4.997766e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0012133 | Erythroid hypoplasia | Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 8 | 1.361470e-11 | 1 |
| HP | HP:0031640 | Abnormal radial artery morphology | Any structural anomaly of the radial artery. | 7 | 6.416822e-10 | 1 |
| HP | HP:0030270 | Elevated red cell adenosine deaminase activity | Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine. | 7 | 6.416822e-10 | 1 |
| HP | HP:0020118 | Radial artery aplasia | Congenital absence of the radial artery. | 7 | 6.416822e-10 | 1 |
| HP | HP:4000209 | Abnormal erythrocyte adenosine deaminase activity | Activity of adenosine deaminase in red blood cells outside the limits of normal. | 7 | 8.649224e-10 | 1 |
| HP | HP:0005532 | Macrocytic dyserythropoietic anemia | Macrocytic dyserythropoietic anemia | 7 | 1.151434e-09 | 1 |
| HP | HP:0012131 | Abnormal number of erythroid precursors | A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 8 | 1.260858e-09 | 1 |
| HP | HP:0012410 | Pure red cell aplasia | A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction. | 7 | 1.973577e-09 | 1 |
| HP | HP:0001227 | Abnormality of the thenar eminence | An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb. | 7 | 6.468358e-09 | 1 |
| HP | HP:0040276 | Adenocarcinoma of the colon | Adenocarcinoma of the colon | 7 | 6.468358e-09 | 1 |
| HP | HP:0006758 | Malignant genitourinary tract tumor | The presence of a malignant neoplasm of the genital system. | 7 | 8.017169e-09 | 1 |
| HP | HP:0001894 | Thrombocytosis | Increased numbers of platelets in the peripheral blood. | 8 | 9.434519e-09 | 1 |
| HP | HP:0011904 | Persistence of hemoglobin F | Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent. | 7 | 9.872425e-09 | 1 |
| HP | HP:0001896 | Reticulocytopenia | A reduced number of reticulocytes in the peripheral blood. | 7 | 9.872425e-09 | 1 |
| HP | HP:0002669 | Osteosarcoma | A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. | 7 | 9.872425e-09 | 1 |
| HP | HP:0001895 | Normochromic anemia | Normochromic anemia | 7 | 1.470296e-08 | 1 |
| HP | HP:0040275 | Adenocarcinoma of the large intestine | A malignant epithelial tumor with a glandular organization that originates in the large intestine. | 7 | 1.470296e-08 | 1 |
| HP | HP:0002863 | Myelodysplasia | Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia. | 9 | 1.473310e-08 | 1 |
| HP | HP:0001972 | Macrocytic anemia | A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH). | 8 | 2.447769e-08 | 1 |
| HP | HP:0009944 | Partial duplication of thumb phalanx | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 7 | 2.566864e-08 | 1 |
| HP | HP:0004808 | Acute myeloid leukemia | A form of leukemia characterized by overproduction of an early myeloid cell. | 8 | 3.053725e-08 | 1 |
| HP | HP:0040273 | Adenocarcinoma of the intestines | A malignant epithelial tumor with a glandular organization that originates in the intestines. | 7 | 3.061192e-08 | 1 |
| HP | HP:0009999 | Partial duplication of the phalanx of hand | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 7 | 3.634654e-08 | 1 |
| HP | HP:0030272 | Abnormal erythrocyte enzyme concentration or activity | An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme. | 7 | 8.084141e-08 | 1 |
| HP | HP:0005518 | Increased mean corpuscular volume | Larger than normal size of erythrocytes. | 7 | 1.253160e-07 | 1 |
| HP | HP:0000912 | Sprengel anomaly | A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other). | 7 | 1.653719e-07 | 1 |
| HP | HP:0009777 | Absent thumb | Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues. | 7 | 2.790097e-07 | 1 |
| HP | HP:0009942 | Duplication of thumb phalanx | Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits. | 7 | 3.572592e-07 | 1 |
| HP | HP:0000185 | Cleft soft palate | Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency. | 7 | 3.572592e-07 | 1 |
| HP | HP:0025065 | Abnormal mean corpuscular volume | A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters. | 7 | 4.535113e-07 | 1 |
| HP | HP:0001790 | Nonimmune hydrops fetalis | A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens . | 7 | 7.136761e-07 | 1 |
| HP | HP:0001199 | Triphalangeal thumb | A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb. | 7 | 1.091679e-06 | 1 |
| HP | HP:0002488 | Acute leukemia | A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). | 8 | 1.194692e-06 | 1 |
| HP | HP:0001087 | Developmental glaucoma | Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma. | 7 | 1.793387e-06 | 1 |
| HP | HP:0002672 | Gastrointestinal carcinoma | Gastrointestinal carcinoma | 7 | 1.793387e-06 | 1 |
| HP | HP:0006749 | Malignant gastrointestinal tract tumors | Malignant gastrointestinal tract tumors | 7 | 1.793387e-06 | 1 |
| HP | HP:0009778 | Short thumb | Hypoplasia (congenital reduction in size) of the thumb. | 8 | 1.894177e-06 | 1 |
| HP | HP:0011902 | Abnormal hemoglobin | Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes. | 7 | 2.166047e-06 | 1 |
| HP | HP:0004377 | Hematological neoplasm | Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). | 10 | 3.231224e-06 | 1 |
| HP | HP:0100273 | Neoplasm of the colon | Neoplasm of the colon | 7 | 3.397515e-06 | 1 |
| HP | HP:0004312 | Abnormal reticulocyte morphology | A reticulocyte abnormality. | 7 | 4.035056e-06 | 1 |
| HP | HP:0009601 | Aplasia/Hypoplasia of the thumb | Hypoplastic/small or absent thumb. | 8 | 7.262801e-06 | 1 |
| HP | HP:0000294 | Low anterior hairline | Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella. | 8 | 7.660969e-06 | 1 |
| HP | HP:0009380 | Finger aplasia | A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers). | 7 | 7.706909e-06 | 1 |
| HP | HP:0000085 | Horseshoe kidney | A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline. | 8 | 8.077950e-06 | 1 |
| HP | HP:0000980 | Pallor | Abnormally pale skin. | 8 | 9.949315e-06 | 1 |
| HP | HP:0001882 | Decreased total leukocyte count | An abnormal decreased number of leukocytes in the blood. | 8 | 1.218594e-05 | 1 |
| HP | HP:0010622 | Neoplasm of the skeletal system | A tumor (abnormal growth of tissue) of the skeleton. | 7 | 1.961744e-05 | 1 |
| HP | HP:0001909 | Leukemia | A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. | 8 | 2.273771e-05 | 1 |
| HP | HP:0001874 | Abnormality of neutrophils | A neutrophil abnormality. | 9 | 3.359284e-05 | 1 |
| HP | HP:0100834 | Neoplasm of the large intestine | The presence of a neoplasm of the large intestine. | 7 | 3.717190e-05 | 1 |
| HP | HP:0000465 | Webbed neck | Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline. | 7 | 6.296217e-05 | 1 |
| HP | HP:0001789 | Hydrops fetalis | The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema. | 7 | 7.438635e-05 | 1 |
| HP | HP:0010972 | Anemia of inadequate production | A kind of anemia characterized by inadequate production of erythrocytes. | 8 | 7.769375e-05 | 1 |
| HP | HP:0001421 | Abnormality of the musculature of the hand | Abnormality of the musculature of the hand | 7 | 7.856530e-05 | 1 |
| HP | HP:0001875 | Decreased total neutrophil count | Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group. | 8 | 1.055188e-04 | 1 |
| HP | HP:0001911 | Abnormal granulocyte morphology | Any structural abnormality or abnormal count of granulocytes. | 9 | 1.466687e-04 | 1 |
| HP | HP:0000599 | Abnormality of the frontal hairline | An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not. | 8 | 1.467583e-04 | 1 |
| HP | HP:0000519 | Developmental cataract | A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens. | 7 | 1.615880e-04 | 1 |
| HP | HP:0011991 | Abnormal total neutrophil count | A deviation from the normal range of neutrophil cell counts in the circulation. | 8 | 2.082686e-04 | 1 |
| HP | HP:0001680 | Coarctation of aorta | Coarctation of the aorta is a narrowing or constriction of a segment of the aorta. | 7 | 2.830883e-04 | 1 |
| HP | HP:0010974 | Abnormal myeloid leukocyte morphology | An abnormality of myeloid leukocytes. | 9 | 2.987927e-04 | 1 |
| HP | HP:0100542 | Abnormal localization of kidney | An abnormal site of the kidney. | 8 | 3.311095e-04 | 1 |
| HP | HP:0001903 | Anemia | A reduction in erythrocytes volume or hemoglobin concentration. | 11 | 4.057817e-04 | 1 |
| HP | HP:0100242 | Sarcoma | A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. | 7 | 5.150467e-04 | 1 |
| HP | HP:0032309 | Abnormal granulocyte count | Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group. | 8 | 7.948635e-04 | 1 |
| HP | HP:0100736 | Abnormal soft palate morphology | An abnormality of the soft palate. | 8 | 8.177520e-04 | 1 |
| HP | HP:0000782 | Abnormal scapula morphology | Any abnormality of the scapula, also known as the shoulder blade. | 7 | 8.907902e-04 | 1 |
| HP | HP:0001877 | Abnormal erythrocyte morphology | Any structural abnormality of erythrocytes (red-blood cells). | 11 | 1.082137e-03 | 1 |
| HP | HP:0008551 | Microtia | Underdevelopment of the external ear. | 7 | 1.282695e-03 | 1 |
| HP | HP:0009553 | Abnormality of the hairline | The hairline refers to the outline of hair of the head. An abnormality of the hairline can refer to an unusually low or high border between areas of the scalp with and without hair or to abnormal projections of scalp hair. | 8 | 1.607022e-03 | 1 |
| HP | HP:0009602 | Abnormality of thumb phalanx | A structural anomaly of one or more phalanges of the thumb. | 7 | 1.872754e-03 | 1 |
| HP | HP:0000104 | Renal agenesis | Agenesis, that is, failure of the kidney to develop during embryogenesis and development. | 7 | 2.208406e-03 | 1 |
| HP | HP:0008772 | Aplasia/Hypoplasia of the external ear | The presence of aplasia or developmental hypoplasia of all or part of the external ear. | 7 | 2.281278e-03 | 1 |
| HP | HP:0034058 | Abnormal fetal morphology | Any structural anomaly of the fetus. | 8 | 2.342169e-03 | 1 |
| HP | HP:0008771 | Aplasia/Hypoplasia of the ear | The presence of aplasia or developmental hypoplasia of the ear. | 7 | 2.850377e-03 | 1 |
| HP | HP:0009381 | Short finger | Abnormally short finger associated with developmental hypoplasia. | 8 | 3.196697e-03 | 1 |
| HP | HP:0011361 | Congenital abnormal hair pattern | A congenital abnormality of the distribution of hair growth. | 8 | 3.349391e-03 | 1 |
| HP | HP:0410030 | Cleft lip | A gap in the lip or lips. | 7 | 3.429108e-03 | 1 |
| HP | HP:0011873 | Abnormal platelet count | Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood. | 9 | 3.489008e-03 | 1 |
| HP | HP:0011875 | Abnormal platelet morphology | An anomaly in platelet form, ultrastructure, or intracellular organelles. | 9 | 3.756056e-03 | 1 |
| HP | HP:0000286 | Epicanthus | A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus. | 10 | 4.298609e-03 | 1 |
| HP | HP:0009997 | Duplication of phalanx of hand | This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated. | 7 | 4.351938e-03 | 1 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 7 | 4.612711e-03 | 1 |
| HP | HP:0009142 | Duplication of bones involving the upper extremities | Duplication of bones involving the upper extremities | 7 | 4.612711e-03 | 1 |
| HP | HP:0004275 | Duplication of hand bones | Duplication of hand bones | 7 | 4.612711e-03 | 1 |
| HP | HP:0001872 | Abnormality of thrombocytes | An abnormality of platelets. | 9 | 5.967770e-03 | 1 |
| HP | HP:0011792 | Neoplasm by histology | Neoplasm categorized according to type of histological abnormality. | 8 | 6.376812e-03 | 1 |
| HP | HP:0001254 | Lethargy | A state of fatigue, either physical or mental slowness and sluggishness, with difficulties in initiating or performing simple tasks. Distinguished from apathy which implies indifference and a lack of desire or interest in the task. A person with lethargy may have the desire, but not the energy to engage in personal or socially relevant tasks. | 7 | 7.020494e-03 | 1 |
| HP | HP:0011893 | Abnormal leukocyte count | Number of leukocytes per volume of blood beyond normal limits. | 9 | 8.649567e-03 | 1 |
| HP | HP:0006265 | Aplasia/Hypoplasia of fingers | Small/hypoplastic or absent/aplastic fingers. | 8 | 8.703843e-03 | 1 |
| HP | HP:0000431 | Wide nasal bridge | Increased breadth of the nasal bridge (and with it, the nasal root). | 9 | 9.387739e-03 | 1 |
| HP | HP:0001629 | Ventricular septal defect | A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum. | 9 | 9.387739e-03 | 1 |
| HP | HP:0010720 | Abnormal hair pattern | An abnormality of the distribution of hair growth. | 8 | 9.625668e-03 | 1 |
| HP | HP:0010438 | Abnormal ventricular septum morphology | A structural abnormality of the interventricular septum. | 9 | 1.120691e-02 | 1 |
| HP | HP:0001518 | Small for gestational age | Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age. | 7 | 1.270908e-02 | 1 |
| HP | HP:0001172 | Abnormal thumb morphology | An abnormal structure of the first digit of the hand. | 8 | 1.446691e-02 | 1 |
| HP | HP:0001679 | Abnormal aortic morphology | An abnormality of the aorta. | 8 | 1.742093e-02 | 1 |
| HP | HP:0001446 | Abnormality of the musculature of the upper limbs | Abnormality of the musculature of the upper limbs | 7 | 1.818629e-02 | 1 |
| HP | HP:0011793 | Neoplasm by anatomical site | Neoplasm categorized according to the anatomical site of origin of the neoplasm. | 11 | 2.172381e-02 | 1 |
| HP | HP:0001873 | Thrombocytopenia | A reduction in the number of circulating thrombocytes. | 8 | 2.362571e-02 | 1 |
| HP | HP:0007378 | Neoplasm of the gastrointestinal tract | A tumor (abnormal growth of tissue) of the gastrointestinal tract. | 7 | 2.441201e-02 | 1 |
| HP | HP:0034057 | Fetal anomaly | Structural or functional abnormalities of the fetus. Note that this section comprises terms that describe abnormalities that are specific to the fetus or differ from the corresponding general terms. A term from anywhere in the Human Phenotype Ontology can be applied to a fetus if appropriate. | 9 | 2.457627e-02 | 1 |
| HP | HP:0002664 | Neoplasm | An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor). | 11 | 2.827336e-02 | 1 |
| HP | HP:0100037 | Abnormality of the scalp hair | An abnormality of the hair of head. | 8 | 2.857101e-02 | 1 |
| HP | HP:0000369 | Low-set ears | Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear. | 10 | 3.150193e-02 | 1 |
| HP | HP:0001965 | Abnormal scalp morphology | Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows. | 8 | 3.793673e-02 | 1 |
| HP | HP:0000218 | High palate | Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective). | 10 | 4.113317e-02 | 1 |
| HP | HP:0001871 | Abnormality of blood and blood-forming tissues | An abnormality of the hematopoietic system. | 13 | 4.157973e-02 | 1 |
| HP | HP:0005280 | Depressed nasal bridge | Posterior positioning of the nasal root in relation to the overall facial profile for age. | 9 | 4.501769e-02 | 1 |
| HP | HP:0007700 | Ocular anterior segment dysgenesis | Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin. | 7 | 4.579761e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 25 | 3.787028e-08 | 1 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 31 | 1.328144e-06 | 1 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 32 | 2.463246e-06 | 1 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 22 | 4.499581e-06 | 1 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 18 | 1.195532e-05 | 1 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 34 | 1.880717e-05 | 1 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 31 | 3.772092e-05 | 1 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 19 | 5.032946e-05 | 1 |
| HPA | HPA:0620000 | Vagina | Vagina | 36 | 5.946326e-05 | 1 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 36 | 5.946326e-05 | 1 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 30 | 1.117198e-04 | 1 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 33 | 1.302483e-04 | 1 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 34 | 1.795505e-04 | 1 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 17 | 2.145907e-04 | 1 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 38 | 4.396730e-04 | 1 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 38 | 4.396730e-04 | 1 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 35 | 4.436599e-04 | 1 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 32 | 5.273481e-04 | 1 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 37 | 6.778861e-04 | 1 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 37 | 6.778861e-04 | 1 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 18 | 7.402881e-04 | 1 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 36 | 9.128795e-04 | 1 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 31 | 1.598157e-03 | 1 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 23 | 1.731399e-03 | 1 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 15 | 1.836702e-03 | 1 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 28 | 1.845766e-03 | 1 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 28 | 2.736918e-03 | 1 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 16 | 3.879811e-03 | 1 |
| HPA | HPA:0630000 | Cervix | Cervix | 36 | 5.847924e-03 | 1 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 31 | 5.936798e-03 | 1 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 30 | 6.663652e-03 | 1 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 25 | 7.356840e-03 | 1 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 28 | 8.501504e-03 | 1 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 37 | 9.642513e-03 | 1 |
| HPA | HPA:0400000 | Rectum | Rectum | 38 | 1.048958e-02 | 1 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 17 | 1.124814e-02 | 1 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 35 | 1.154079e-02 | 1 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 35 | 1.154079e-02 | 1 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 33 | 1.171860e-02 | 1 |
| HPA | HPA:0380000 | Placenta | Placenta | 37 | 1.182642e-02 | 1 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 20 | 1.185646e-02 | 1 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 31 | 1.189523e-02 | 1 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 19 | 1.342815e-02 | 1 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 15 | 1.590274e-02 | 1 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 21 | 1.801431e-02 | 1 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 13 | 1.846585e-02 | 1 |
| HPA | HPA:0030053 | Appendix; glandular cells[High] | Appendix; glandular cells[High] | 17 | 1.952028e-02 | 1 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 35 | 2.193164e-02 | 1 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 35 | 2.193164e-02 | 1 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 14 | 2.244304e-02 | 1 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 33 | 2.856284e-02 | 1 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 12 | 3.249352e-02 | 1 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 30 | 3.453631e-02 | 1 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 35 | 3.560336e-02 | 1 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 29 | 3.607213e-02 | 1 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 33 | 3.705693e-02 | 1 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 37 | 3.854069e-02 | 1 |
| HPA | HPA:0080000 | Caudate | Caudate | 35 | 3.916777e-02 | 1 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 36 | 4.672443e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 17 | 0.000154 | 1 |
| MIRNA | MIRNA:hsa-mir-1180-3p | hsa-mir-1180-3p | hsa-mir-1180-3p | 4 | 0.015146 | 1 |
| MIRNA | MIRNA:hsa-mir-652-3p | hsa-mir-652-3p | hsa-mir-652-3p | 5 | 0.019533 | 1 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 13 | 0.027637 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11882_1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | 41 | 0.046306 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 8 | 0.000014 | 2 |
| GO:CC | GO:0005814 | centriole | "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] | 5 | 0.000033 | 2 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 8 | 0.000051 | 2 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 9 | 0.000158 | 2 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 15 | 0.000191 | 2 |
| GO:CC | GO:0005929 | cilium | "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] | 6 | 0.005727 | 2 |
| GO:CC | GO:0000932 | P-body | "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603] | 3 | 0.013255 | 2 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 9 | 0.013535 | 2 |
| GO:CC | GO:0000242 | pericentriolar material | "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] | 2 | 0.024985 | 2 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 18 | 0.048251 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 8 | 0.000081 | 2 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 10 | 0.000110 | 2 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 14 | 0.000125 | 2 |
| GO:BP | GO:0070925 | organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 9 | 0.000151 | 2 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 10 | 0.000288 | 2 |
| GO:BP | GO:0007017 | microtubule-based process | "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] | 8 | 0.001707 | 2 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 13 | 0.001798 | 2 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 6 | 0.002185 | 2 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 10 | 0.003660 | 2 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 12 | 0.004191 | 2 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 11 | 0.007922 | 2 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 11 | 0.008270 | 2 |
| GO:BP | GO:0007098 | centrosome cycle | "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] | 4 | 0.009646 | 2 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 7 | 0.012393 | 2 |
| GO:BP | GO:0031023 | microtubule organizing center organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] | 4 | 0.013709 | 2 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 10 | 0.020712 | 2 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 7 | 0.025497 | 2 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 14 | 0.032413 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | Loss of proteins required for interphase microtubule organization from the centrosome | 4 | 0.000551 | 2 |
| REAC | REAC:R-HSA-380259 | Loss of Nlp from mitotic centrosomes | Loss of Nlp from mitotic centrosomes | 4 | 0.000551 | 2 |
| REAC | REAC:R-HSA-8854518 | AURKA Activation by TPX2 | AURKA Activation by TPX2 | 4 | 0.000656 | 2 |
| REAC | REAC:R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | Recruitment of mitotic centrosome proteins and complexes | 4 | 0.001059 | 2 |
| REAC | REAC:R-HSA-380287 | Centrosome maturation | Centrosome maturation | 4 | 0.001059 | 2 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 4 | 0.001351 | 2 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 4 | 0.002020 | 2 |
| REAC | REAC:R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | Anchoring of the basal body to the plasma membrane | 4 | 0.002197 | 2 |
| REAC | REAC:R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | 3 | 0.004536 | 2 |
| REAC | REAC:R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | NR1H2 and NR1H3-mediated signaling | 3 | 0.008948 | 2 |
| REAC | REAC:R-HSA-426496 | Post-transcriptional silencing by small RNAs | Post-transcriptional silencing by small RNAs | 2 | 0.011554 | 2 |
| REAC | REAC:R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2 | 0.015393 | 2 |
| REAC | REAC:R-HSA-8943723 | Regulation of PTEN mRNA translation | Regulation of PTEN mRNA translation | 2 | 0.019776 | 2 |
| REAC | REAC:R-HSA-9768778 | Regulation of NPAS4 mRNA translation | Regulation of NPAS4 mRNA translation | 2 | 0.019776 | 2 |
| REAC | REAC:R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | Regulation of CDH11 mRNA translation by microRNAs | 2 | 0.019776 | 2 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 4 | 0.036382 | 2 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 4 | 0.037841 | 2 |
| REAC | REAC:R-HSA-68877 | Mitotic Prometaphase | Mitotic Prometaphase | 4 | 0.039341 | 2 |
| REAC | REAC:R-HSA-5617833 | Cilium Assembly | Cilium Assembly | 4 | 0.039341 | 2 |
| REAC | REAC:R-HSA-9768759 | Regulation of NPAS4 gene expression | Regulation of NPAS4 gene expression | 2 | 0.042713 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4797-3p | hsa-mir-4797-3p | hsa-mir-4797-3p | 8 | 0.001446 | 2 |
| MIRNA | MIRNA:hsa-mir-4264 | hsa-mir-4264 | hsa-mir-4264 | 8 | 0.002703 | 2 |
| MIRNA | MIRNA:hsa-mir-4285 | hsa-mir-4285 | hsa-mir-4285 | 3 | 0.013530 | 2 |
| MIRNA | MIRNA:hsa-mir-106b-5p | hsa-mir-106b-5p | hsa-mir-106b-5p | 7 | 0.037353 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 4 | 0.004189 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 7 | 0.009898 | 2 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 9 | 0.025834 | 2 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 7 | 0.033502 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M10001 | Factor: NF-E2p45; motif: NNRTGACTCAGCA | Factor: NF-E2p45; motif: NNRTGACTCAGCA | 4 | 0.027393 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 3 | 0.030414 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005832 | chaperonin-containing T-complex | "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] | 5 | 2.816280e-13 | 3 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 5 | 8.316597e-10 | 3 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 7 | 8.404197e-08 | 3 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 9 | 1.037503e-07 | 3 |
| GO:CC | GO:0002199 | zona pellucida receptor complex | "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] | 3 | 5.479593e-07 | 3 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 7 | 2.945200e-06 | 3 |
| GO:CC | GO:0044297 | cell body | "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] | 6 | 1.233651e-05 | 3 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 9 | 1.279412e-05 | 3 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 7 | 1.778579e-05 | 3 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 7 | 1.871767e-05 | 3 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 10 | 3.919838e-05 | 3 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 8 | 9.163612e-05 | 3 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 8 | 1.022032e-04 | 3 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 8 | 1.025728e-04 | 3 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 8 | 1.025728e-04 | 3 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 7 | 1.413610e-04 | 3 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 10 | 8.617540e-04 | 3 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 11 | 1.375116e-03 | 3 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 8 | 2.895350e-03 | 3 |
| GO:CC | GO:0090443 | FAR/SIN/STRIPAK complex | "A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body." [GOC:vw, PMID:21561862, PMID:22119525] | 2 | 3.265840e-03 | 3 |
| GO:CC | GO:0000159 | protein phosphatase type 2A complex | "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430] | 2 | 4.104089e-03 | 3 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 5 | 5.632963e-03 | 3 |
| GO:CC | GO:0005868 | cytoplasmic dynein complex | "Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311] | 2 | 6.065554e-03 | 3 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 8 | 1.881245e-02 | 3 |
| GO:CC | GO:0030286 | dynein complex | "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] | 2 | 3.402058e-02 | 3 |
| GO:CC | GO:1903293 | phosphatase complex | "A protein complex which is capable of phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807] | 2 | 3.659211e-02 | 3 |
| GO:CC | GO:0008287 | protein serine/threonine phosphatase complex | "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf] | 2 | 3.659211e-02 | 3 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 4 | 3.748603e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051086 | chaperone mediated protein folding independent of cofactor | "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] | 5 | 9.441360e-13 | 3 |
| GO:BP | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 5 | 2.123801e-12 | 3 |
| GO:BP | GO:1904871 | positive regulation of protein localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 5 | 4.246591e-12 | 3 |
| GO:BP | GO:1904869 | regulation of protein localization to Cajal body | "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 5 | 4.246591e-12 | 3 |
| GO:BP | GO:1903405 | protein localization to nuclear body | "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] | 5 | 1.334008e-11 | 3 |
| GO:BP | GO:1904867 | protein localization to Cajal body | "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 5 | 1.334008e-11 | 3 |
| GO:BP | GO:1904872 | regulation of telomerase RNA localization to Cajal body | "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 5 | 1.334008e-11 | 3 |
| GO:BP | GO:1990173 | protein localization to nucleoplasm | "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] | 5 | 3.370471e-11 | 3 |
| GO:BP | GO:0090672 | telomerase RNA localization | "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 5 | 1.955306e-10 | 3 |
| GO:BP | GO:0090685 | RNA localization to nucleus | "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] | 5 | 1.955306e-10 | 3 |
| GO:BP | GO:0090670 | RNA localization to Cajal body | "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 5 | 1.955306e-10 | 3 |
| GO:BP | GO:0090671 | telomerase RNA localization to Cajal body | "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 5 | 1.955306e-10 | 3 |
| GO:BP | GO:0032212 | positive regulation of telomere maintenance via telomerase | "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 5 | 7.138760e-10 | 3 |
| GO:BP | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 5 | 1.354933e-09 | 3 |
| GO:BP | GO:0051084 | 'de novo' post-translational protein folding | "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] | 5 | 1.609434e-08 | 3 |
| GO:BP | GO:0032210 | regulation of telomere maintenance via telomerase | "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 5 | 2.290221e-08 | 3 |
| GO:BP | GO:0006458 | 'de novo' protein folding | "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] | 5 | 2.859511e-08 | 3 |
| GO:BP | GO:2000573 | positive regulation of DNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 5 | 3.920077e-08 | 3 |
| GO:BP | GO:1904356 | regulation of telomere maintenance via telomere lengthening | "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 5 | 5.799775e-08 | 3 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 5 | 9.094566e-08 | 3 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 5 | 1.169614e-07 | 3 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 5 | 2.493462e-07 | 3 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 5 | 2.673511e-07 | 3 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 5 | 2.863793e-07 | 3 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 5 | 8.126777e-07 | 3 |
| GO:BP | GO:1900182 | positive regulation of protein localization to nucleus | "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 5 | 9.568122e-07 | 3 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 5 | 1.590772e-06 | 3 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 5 | 2.206403e-06 | 3 |
| GO:BP | GO:0007339 | binding of sperm to zona pellucida | "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] | 4 | 4.586313e-06 | 3 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 5 | 8.415525e-06 | 3 |
| GO:BP | GO:0008037 | cell recognition | "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators] | 5 | 1.292510e-05 | 3 |
| GO:BP | GO:0035036 | sperm-egg recognition | "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf] | 4 | 1.464425e-05 | 3 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 5 | 1.510069e-05 | 3 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 5 | 1.917974e-05 | 3 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 5 | 3.242999e-05 | 3 |
| GO:BP | GO:0006403 | RNA localization | "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] | 5 | 4.083507e-05 | 3 |
| GO:BP | GO:0009988 | cell-cell recognition | "Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820] | 4 | 6.042912e-05 | 3 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 5 | 6.427449e-05 | 3 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 5 | 7.194267e-05 | 3 |
| GO:BP | GO:0033044 | regulation of chromosome organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] | 5 | 1.057816e-04 | 3 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 5 | 2.646960e-04 | 3 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 7 | 3.720844e-04 | 3 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 5 | 4.110360e-04 | 3 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 5 | 5.319762e-04 | 3 |
| GO:BP | GO:1904851 | positive regulation of establishment of protein localization to telomere | "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 2 | 9.328404e-04 | 3 |
| GO:BP | GO:0007338 | single fertilization | "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] | 4 | 1.786174e-03 | 3 |
| GO:BP | GO:0090666 | scaRNA localization to Cajal body | "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 2 | 3.107693e-03 | 3 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 5 | 3.533579e-03 | 3 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 5 | 3.786877e-03 | 3 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 5 | 3.824203e-03 | 3 |
| GO:BP | GO:0009566 | fertilization | "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] | 4 | 4.300975e-03 | 3 |
| GO:BP | GO:1904816 | positive regulation of protein localization to chromosome, telomeric region | "Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455] | 2 | 4.660210e-03 | 3 |
| GO:BP | GO:0070203 | regulation of establishment of protein localization to telomere | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah] | 2 | 4.660210e-03 | 3 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 5 | 5.522891e-03 | 3 |
| GO:BP | GO:0070202 | regulation of establishment of protein localization to chromosome | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] | 2 | 6.522432e-03 | 3 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 5 | 7.509164e-03 | 3 |
| GO:BP | GO:1904814 | regulation of protein localization to chromosome, telomeric region | "Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455] | 2 | 1.396468e-02 | 3 |
| GO:BP | GO:0070200 | establishment of protein localization to telomere | "The directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah] | 2 | 2.046984e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-390450 | Folding of actin by CCT/TriC | Folding of actin by CCT/TriC | 5 | 1.296283e-11 | 3 |
| REAC | REAC:R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | Formation of tubulin folding intermediates by CCT/TriC | 5 | 3.363243e-09 | 3 |
| REAC | REAC:R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | Prefoldin mediated transfer of substrate to CCT/TriC | 5 | 5.021112e-09 | 3 |
| REAC | REAC:R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 5 | 1.210248e-08 | 3 |
| REAC | REAC:R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 5 | 2.554699e-08 | 3 |
| REAC | REAC:R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | Association of TriC/CCT with target proteins during biosynthesis | 5 | 2.554699e-08 | 3 |
| REAC | REAC:R-HSA-390466 | Chaperonin-mediated protein folding | Chaperonin-mediated protein folding | 5 | 2.319663e-06 | 3 |
| REAC | REAC:R-HSA-391251 | Protein folding | Protein folding | 5 | 3.207253e-06 | 3 |
| REAC | REAC:R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | BBSome-mediated cargo-targeting to cilium | 3 | 2.604765e-04 | 3 |
| REAC | REAC:R-HSA-5620920 | Cargo trafficking to the periciliary membrane | Cargo trafficking to the periciliary membrane | 3 | 3.022195e-03 | 3 |
| REAC | REAC:R-HSA-5617833 | Cilium Assembly | Cilium Assembly | 4 | 5.607968e-03 | 3 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 8 | 1.302930e-02 | 3 |
| REAC | REAC:R-HSA-141424 | Amplification of signal from the kinetochores | Amplification of signal from the kinetochores | 3 | 1.787042e-02 | 3 |
| REAC | REAC:R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | 3 | 1.787042e-02 | 3 |
| REAC | REAC:R-HSA-1852241 | Organelle biogenesis and maintenance | Organelle biogenesis and maintenance | 4 | 2.437150e-02 | 3 |
| REAC | REAC:R-HSA-69618 | Mitotic Spindle Checkpoint | Mitotic Spindle Checkpoint | 3 | 2.963186e-02 | 3 |
| REAC | REAC:R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | EML4 and NUDC in mitotic spindle formation | 3 | 3.475015e-02 | 3 |
| REAC | REAC:R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | Resolution of Sister Chromatid Cohesion | 3 | 4.345979e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:126 | CCT complex (chaperonin containing TCP1 complex) | CCT complex (chaperonin containing TCP1 complex) | 5 | 3.400097e-10 | 3 |
| CORUM | CORUM:6247 | BBS-chaperonin complex | BBS-chaperonin complex | 3 | 2.756150e-04 | 3 |
| CORUM | CORUM:6182 | PP2A A/C-striatin complex | PP2A A/C-striatin complex | 2 | 1.119749e-03 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 5 | 5.483634e-10 | 3 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 5 | 3.333578e-08 | 3 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 5 | 4.439004e-07 | 3 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 7 | 1.542383e-06 | 3 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 5 | 2.800176e-04 | 3 |
| GO:MF | GO:0045503 | dynein light chain binding | "Binding to a light chain of the dynein complex." [GOC:bf] | 2 | 1.920584e-03 | 3 |
| GO:MF | GO:0045504 | dynein heavy chain binding | "Binding to a heavy chain of the dynein complex." [GOC:bf] | 2 | 6.388676e-03 | 3 |
| GO:MF | GO:0016787 | hydrolase activity | "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] | 8 | 9.189891e-03 | 3 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 6 | 1.156205e-02 | 3 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 6 | 1.349758e-02 | 3 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 6 | 1.872649e-02 | 3 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 7 | 1.989770e-02 | 3 |
| GO:MF | GO:0051721 | protein phosphatase 2A binding | "Binding to protein phosphatase 2A." [GOC:ai] | 2 | 2.306304e-02 | 3 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 10 | 2.836685e-02 | 3 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 5 | 4.959849e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4949 | 16p11 2 proximal deletion syndrome | 16p11 2 proximal deletion syndrome | 6 | 2.066078e-08 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 11 | 0.003395 | 3 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 11 | 0.021012 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04962 | Vasopressin-regulated water reabsorption | Vasopressin-regulated water reabsorption | 2 | 0.01276 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 9 | 5.915621e-11 | 4 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 8 | 1.112290e-10 | 4 |
| GO:CC | GO:0030863 | cortical cytoskeleton | "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] | 6 | 2.015820e-09 | 4 |
| GO:CC | GO:0005884 | actin filament | "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] | 6 | 2.596563e-09 | 4 |
| GO:CC | GO:0030426 | growth cone | "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] | 6 | 1.725147e-08 | 4 |
| GO:CC | GO:0030427 | site of polarized growth | "Any part of a cell where non-isotropic growth takes place." [GOC:mah] | 6 | 2.060085e-08 | 4 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 8 | 3.814666e-07 | 4 |
| GO:CC | GO:0150034 | distal axon | "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] | 6 | 3.815864e-07 | 4 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 10 | 1.317223e-06 | 4 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 8 | 1.320434e-06 | 4 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 8 | 1.400064e-06 | 4 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 10 | 1.766390e-06 | 4 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 6 | 4.560209e-06 | 4 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 6 | 5.233304e-06 | 4 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 8 | 1.423802e-05 | 4 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 9 | 2.759292e-05 | 4 |
| GO:CC | GO:0005903 | brush border | "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] | 4 | 3.078453e-05 | 4 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 9 | 4.245125e-05 | 4 |
| GO:CC | GO:0030424 | axon | "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] | 6 | 5.988753e-05 | 4 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 12 | 6.140400e-05 | 4 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 12 | 6.151467e-05 | 4 |
| GO:CC | GO:0098862 | cluster of actin-based cell projections | "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] | 4 | 1.843979e-04 | 4 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 10 | 2.033990e-04 | 4 |
| GO:CC | GO:0043005 | neuron projection | "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] | 7 | 2.121080e-04 | 4 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 6 | 2.179487e-04 | 4 |
| GO:CC | GO:0001726 | ruffle | "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] | 4 | 2.412135e-04 | 4 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 8 | 2.607489e-04 | 4 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 8 | 2.904376e-04 | 4 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 8 | 2.914754e-04 | 4 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 8 | 2.914754e-04 | 4 |
| GO:CC | GO:0016459 | myosin complex | "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin] | 3 | 4.105339e-04 | 4 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 11 | 4.520587e-04 | 4 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 5 | 5.694081e-04 | 4 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 9 | 5.937102e-04 | 4 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 11 | 1.048151e-03 | 4 |
| GO:CC | GO:0030864 | cortical actin cytoskeleton | "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] | 3 | 1.303335e-03 | 4 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 9 | 4.947231e-03 | 4 |
| GO:CC | GO:0031252 | cell leading edge | "The area of a motile cell closest to the direction of movement." [GOC:pg] | 4 | 7.011323e-03 | 4 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 7 | 1.406203e-02 | 4 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 7 | 1.427632e-02 | 4 |
| GO:CC | GO:0008180 | COP9 signalosome | "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] | 2 | 1.765271e-02 | 4 |
| GO:CC | GO:0002102 | podosome | "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] | 2 | 2.428421e-02 | 4 |
| GO:CC | GO:0030659 | cytoplasmic vesicle membrane | "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] | 5 | 3.613507e-02 | 4 |
| GO:CC | GO:0012506 | vesicle membrane | "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] | 5 | 3.876377e-02 | 4 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 9 | 4.323972e-02 | 4 |
| GO:CC | GO:0098590 | plasma membrane region | "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] | 5 | 4.820680e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 8 | 4.960205e-09 | 4 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 7 | 5.253309e-08 | 4 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 9 | 7.317228e-08 | 4 |
| GO:MF | GO:0051015 | actin filament binding | "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 6 | 2.206080e-07 | 4 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 7 | 1.964944e-06 | 4 |
| GO:MF | GO:0005516 | calmodulin binding | "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] | 5 | 1.818659e-05 | 4 |
| GO:MF | GO:0000146 | microfilament motor activity | "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949] | 3 | 2.727958e-04 | 4 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 7 | 6.319352e-04 | 4 |
| GO:MF | GO:0005522 | profilin binding | "Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544] | 2 | 3.226317e-03 | 4 |
| GO:MF | GO:0044548 | S100 protein binding | "Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] | 2 | 6.515741e-03 | 4 |
| GO:MF | GO:0003774 | cytoskeletal motor activity | "Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949] | 3 | 8.445688e-03 | 4 |
| GO:MF | GO:0120544 | polypeptide conformation or assembly isomerase activity | "Catalysis of a reaction that alters the conformation or assembly of a polypeptide." [EC:5.6.1.-] | 3 | 9.830978e-03 | 4 |
| GO:MF | GO:0005543 | phospholipid binding | "Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] | 4 | 3.234216e-02 | 4 |
| GO:MF | GO:1901981 | phosphatidylinositol phosphate binding | "Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487] | 3 | 3.252183e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 9 | 7.846284e-08 | 4 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 9 | 1.282490e-05 | 4 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 7 | 5.106301e-05 | 4 |
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 6 | 1.139221e-04 | 4 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 7 | 1.193188e-04 | 4 |
| GO:BP | GO:0030048 | actin filament-based movement | "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] | 4 | 1.020824e-03 | 4 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 10 | 1.273351e-03 | 4 |
| GO:BP | GO:0006897 | endocytosis | "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis] | 6 | 1.433289e-03 | 4 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 8 | 3.069957e-03 | 4 |
| GO:BP | GO:0051656 | establishment of organelle localization | "The directed movement of an organelle to a specific location." [GOC:ai] | 5 | 6.033096e-03 | 4 |
| GO:BP | GO:0098657 | import into cell | "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] | 6 | 6.601667e-03 | 4 |
| GO:BP | GO:1905684 | regulation of plasma membrane repair | "Any process that modulates the frequency, rate or extent of plasma membrane repair." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583] | 2 | 8.026335e-03 | 4 |
| GO:BP | GO:0016192 | vesicle-mediated transport | "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] | 7 | 1.017992e-02 | 4 |
| GO:BP | GO:0030050 | vesicle transport along actin filament | "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] | 2 | 1.718293e-02 | 4 |
| GO:BP | GO:0051640 | organelle localization | "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] | 5 | 1.875466e-02 | 4 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 9 | 2.473205e-02 | 4 |
| GO:BP | GO:0031340 | positive regulation of vesicle fusion | "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah] | 2 | 2.518566e-02 | 4 |
| GO:BP | GO:0099515 | actin filament-based transport | "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb] | 2 | 2.518566e-02 | 4 |
| GO:BP | GO:0001921 | positive regulation of receptor recycling | "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add] | 2 | 3.470366e-02 | 4 |
| GO:BP | GO:0042177 | negative regulation of protein catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] | 3 | 4.566127e-02 | 4 |
| GO:BP | GO:1903729 | regulation of plasma membrane organization | "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900] | 2 | 4.573405e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 9 | 9.264764e-08 | 4 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 7 | 1.442094e-06 | 4 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 9 | 2.061816e-06 | 4 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 8 | 6.564972e-06 | 4 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 6 | 6.282003e-05 | 4 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 8 | 8.210247e-05 | 4 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 8 | 8.728464e-05 | 4 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 8 | 1.618826e-04 | 4 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 8 | 2.558426e-04 | 4 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 6 | 5.668304e-04 | 4 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 7 | 1.064004e-03 | 4 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 6 | 3.432599e-03 | 4 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 6 | 3.494610e-03 | 4 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 6 | 5.065120e-03 | 4 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 6 | 5.778591e-03 | 4 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 5 | 5.883783e-03 | 4 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 6 | 6.623946e-03 | 4 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 6 | 7.055064e-03 | 4 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 6 | 8.946092e-03 | 4 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 6 | 9.286265e-03 | 4 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 6 | 1.147201e-02 | 4 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 6 | 1.231555e-02 | 4 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 6 | 1.998510e-02 | 4 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 6 | 2.184718e-02 | 4 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 5 | 3.017644e-02 | 4 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 5 | 3.092503e-02 | 4 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 5 | 3.460986e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5627123 | RHO GTPases activate PAKs | RHO GTPases activate PAKs | 4 | 5.613115e-07 | 4 |
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 7 | 1.151033e-04 | 4 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 7 | 1.330709e-04 | 4 |
| REAC | REAC:R-HSA-195258 | RHO GTPase Effectors | RHO GTPase Effectors | 5 | 1.200341e-03 | 4 |
| REAC | REAC:R-HSA-5625900 | RHO GTPases activate CIT | RHO GTPases activate CIT | 2 | 3.463343e-02 | 4 |
| REAC | REAC:R-HSA-5627117 | RHO GTPases Activate ROCKs | RHO GTPases Activate ROCKs | 2 | 3.463343e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 4 | 0.001753 | 4 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 4 | 0.002050 | 4 |
| KEGG | KEGG:04814 | Motor proteins | Motor proteins | 3 | 0.047568 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12100_1 | Factor: ZNF524; motif: NCTCGNACCCNN; match class: 1 | Factor: ZNF524; motif: NCTCGNACCCNN; match class: 1 | 3 | 0.004763 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 3 | 0.020104 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1844 | APC-IQGAP1 complex | APC-IQGAP1 complex | 1 | 0.049819 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000502 | proteasome complex | "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome] | 7 | 5.896770e-14 | 5 |
| GO:CC | GO:1905369 | endopeptidase complex | "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 7 | 1.159974e-12 | 5 |
| GO:CC | GO:1905368 | peptidase complex | "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 7 | 7.091677e-12 | 5 |
| GO:CC | GO:0005838 | proteasome regulatory particle | "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 5 | 2.935046e-11 | 5 |
| GO:CC | GO:0022624 | proteasome accessory complex | "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] | 5 | 5.917571e-11 | 5 |
| GO:CC | GO:0008540 | proteasome regulatory particle, base subcomplex | "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 4 | 1.748517e-09 | 5 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 8 | 1.702039e-07 | 5 |
| GO:CC | GO:0034515 | proteasome storage granule | "An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:krc, GOC:rb, PMID:18504300, PMID:30204036] | 2 | 2.411133e-05 | 5 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 7 | 5.664688e-04 | 5 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 10 | 8.617540e-04 | 5 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 3 | 4.997999e-02 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | AUF1 (hnRNP D0) binds and destabilizes mRNA | 6 | 5.960805e-10 | 5 |
| REAC | REAC:R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | Regulation of mRNA stability by proteins that bind AU-rich elements | 6 | 1.074276e-08 | 5 |
| REAC | REAC:R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | Cross-presentation of soluble exogenous antigens (endosomes) | 5 | 9.664864e-08 | 5 |
| REAC | REAC:R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | Regulation of activated PAK-2p34 by proteasome mediated degradation | 5 | 1.073466e-07 | 5 |
| REAC | REAC:R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | Regulation of ornithine decarboxylase (ODC) | 5 | 1.189695e-07 | 5 |
| REAC | REAC:R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint | p53-Independent G1/S DNA damage checkpoint | 5 | 1.315758e-07 | 5 |
| REAC | REAC:R-HSA-69610 | p53-Independent DNA Damage Response | p53-Independent DNA Damage Response | 5 | 1.315758e-07 | 5 |
| REAC | REAC:R-HSA-180534 | Vpu mediated degradation of CD4 | Vpu mediated degradation of CD4 | 5 | 1.315758e-07 | 5 |
| REAC | REAC:R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | Autodegradation of the E3 ubiquitin ligase COP1 | 5 | 1.315758e-07 | 5 |
| REAC | REAC:R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5 | 1.315758e-07 | 5 |
| REAC | REAC:R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 5 | 1.315758e-07 | 5 |
| REAC | REAC:R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | Ubiquitin-dependent degradation of Cyclin D | 5 | 1.315758e-07 | 5 |
| REAC | REAC:R-HSA-169911 | Regulation of Apoptosis | Regulation of Apoptosis | 5 | 1.452264e-07 | 5 |
| REAC | REAC:R-HSA-9604323 | Negative regulation of NOTCH4 signaling | Negative regulation of NOTCH4 signaling | 5 | 1.452264e-07 | 5 |
| REAC | REAC:R-HSA-180585 | Vif-mediated degradation of APOBEC3G | Vif-mediated degradation of APOBEC3G | 5 | 1.452264e-07 | 5 |
| REAC | REAC:R-HSA-4641257 | Degradation of AXIN | Degradation of AXIN | 5 | 1.759161e-07 | 5 |
| REAC | REAC:R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5 | 1.759161e-07 | 5 |
| REAC | REAC:R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | SCF-beta-TrCP mediated degradation of Emi1 | 5 | 1.759161e-07 | 5 |
| REAC | REAC:R-HSA-9824272 | Somitogenesis | Somitogenesis | 5 | 1.759161e-07 | 5 |
| REAC | REAC:R-HSA-8941858 | Regulation of RUNX3 expression and activity | Regulation of RUNX3 expression and activity | 5 | 1.759161e-07 | 5 |
| REAC | REAC:R-HSA-5362768 | Hh mutants are degraded by ERAD | Hh mutants are degraded by ERAD | 5 | 1.930894e-07 | 5 |
| REAC | REAC:R-HSA-69541 | Stabilization of p53 | Stabilization of p53 | 5 | 2.115752e-07 | 5 |
| REAC | REAC:R-HSA-4641258 | Degradation of DVL | Degradation of DVL | 5 | 2.115752e-07 | 5 |
| REAC | REAC:R-HSA-351202 | Metabolism of polyamines | Metabolism of polyamines | 5 | 2.314471e-07 | 5 |
| REAC | REAC:R-HSA-5387390 | Hh mutants abrogate ligand secretion | Hh mutants abrogate ligand secretion | 5 | 2.527813e-07 | 5 |
| REAC | REAC:R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | NIK-->noncanonical NF-kB signaling | 5 | 2.527813e-07 | 5 |
| REAC | REAC:R-HSA-5610783 | Degradation of GLI2 by the proteasome | Degradation of GLI2 by the proteasome | 5 | 2.756566e-07 | 5 |
| REAC | REAC:R-HSA-5610780 | Degradation of GLI1 by the proteasome | Degradation of GLI1 by the proteasome | 5 | 2.756566e-07 | 5 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 5 | 2.756566e-07 | 5 |
| REAC | REAC:R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | Dectin-1 mediated noncanonical NF-kB signaling | 5 | 2.756566e-07 | 5 |
| REAC | REAC:R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | GLI3 is processed to GLI3R by the proteasome | 5 | 2.756566e-07 | 5 |
| REAC | REAC:R-HSA-5678895 | Defective CFTR causes cystic fibrosis | Defective CFTR causes cystic fibrosis | 5 | 3.001546e-07 | 5 |
| REAC | REAC:R-HSA-4608870 | Asymmetric localization of PCP proteins | Asymmetric localization of PCP proteins | 5 | 3.842437e-07 | 5 |
| REAC | REAC:R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | Autodegradation of Cdh1 by Cdh1:APC/C | 5 | 3.842437e-07 | 5 |
| REAC | REAC:R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | Antigen processing: Ubiquitination & Proteasome degradation | 7 | 3.859355e-07 | 5 |
| REAC | REAC:R-HSA-5358346 | Hedgehog ligand biogenesis | Hedgehog ligand biogenesis | 5 | 4.161057e-07 | 5 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 5 | 4.500415e-07 | 5 |
| REAC | REAC:R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5 | 4.500415e-07 | 5 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 5 | 4.500415e-07 | 5 |
| REAC | REAC:R-HSA-1169091 | Activation of NF-kappaB in B cells | Activation of NF-kappaB in B cells | 5 | 4.861502e-07 | 5 |
| REAC | REAC:R-HSA-5658442 | Regulation of RAS by GAPs | Regulation of RAS by GAPs | 5 | 4.861502e-07 | 5 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 5 | 5.245339e-07 | 5 |
| REAC | REAC:R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | APC/C:Cdc20 mediated degradation of Securin | 5 | 5.245339e-07 | 5 |
| REAC | REAC:R-HSA-9793380 | Formation of paraxial mesoderm | Formation of paraxial mesoderm | 5 | 5.652980e-07 | 5 |
| REAC | REAC:R-HSA-8948751 | Regulation of PTEN stability and activity | Regulation of PTEN stability and activity | 5 | 5.652980e-07 | 5 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 6 | 6.128188e-07 | 5 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 5 | 6.544041e-07 | 5 |
| REAC | REAC:R-HSA-8939902 | Regulation of RUNX2 expression and activity | Regulation of RUNX2 expression and activity | 5 | 6.544041e-07 | 5 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 6 | 7.069595e-07 | 5 |
| REAC | REAC:R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5 | 7.543746e-07 | 5 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 5 | 7.543746e-07 | 5 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 5 | 8.087316e-07 | 5 |
| REAC | REAC:R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 5 | 8.087316e-07 | 5 |
| REAC | REAC:R-HSA-1234174 | Cellular response to hypoxia | Cellular response to hypoxia | 5 | 8.661684e-07 | 5 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 5 | 9.268132e-07 | 5 |
| REAC | REAC:R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5 | 9.907980e-07 | 5 |
| REAC | REAC:R-HSA-5619084 | ABC transporter disorders | ABC transporter disorders | 5 | 1.058258e-06 | 5 |
| REAC | REAC:R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | The role of GTSE1 in G2/M progression after G2 checkpoint | 5 | 1.129332e-06 | 5 |
| REAC | REAC:R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | Downstream signaling events of B Cell Receptor (BCR) | 5 | 1.204162e-06 | 5 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 5 | 1.282894e-06 | 5 |
| REAC | REAC:R-HSA-9013694 | Signaling by NOTCH4 | Signaling by NOTCH4 | 5 | 1.282894e-06 | 5 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 5 | 1.365679e-06 | 5 |
| REAC | REAC:R-HSA-195253 | Degradation of beta-catenin by the destruction complex | Degradation of beta-catenin by the destruction complex | 5 | 1.452669e-06 | 5 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 5 | 1.544022e-06 | 5 |
| REAC | REAC:R-HSA-5632684 | Hedgehog 'on' state | Hedgehog 'on' state | 5 | 1.639899e-06 | 5 |
| REAC | REAC:R-HSA-983169 | Class I MHC mediated antigen processing & presentation | Class I MHC mediated antigen processing & presentation | 7 | 1.671724e-06 | 5 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 5 | 1.956339e-06 | 5 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 5 | 1.956339e-06 | 5 |
| REAC | REAC:R-HSA-5687128 | MAPK6/MAPK4 signaling | MAPK6/MAPK4 signaling | 5 | 2.071998e-06 | 5 |
| REAC | REAC:R-HSA-1236974 | ER-Phagosome pathway | ER-Phagosome pathway | 5 | 2.193044e-06 | 5 |
| REAC | REAC:R-HSA-4086400 | PCP/CE pathway | PCP/CE pathway | 5 | 2.452042e-06 | 5 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 5 | 2.452042e-06 | 5 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 5 | 2.885696e-06 | 5 |
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 5 | 2.885696e-06 | 5 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 6 | 2.965479e-06 | 5 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 5 | 3.207253e-06 | 5 |
| REAC | REAC:R-HSA-202424 | Downstream TCR signaling | Downstream TCR signaling | 5 | 3.378398e-06 | 5 |
| REAC | REAC:R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | TNFR2 non-canonical NF-kB pathway | 5 | 3.742513e-06 | 5 |
| REAC | REAC:R-HSA-5689603 | UCH proteinases | UCH proteinases | 5 | 4.137240e-06 | 5 |
| REAC | REAC:R-HSA-382556 | ABC-family proteins mediated transport | ABC-family proteins mediated transport | 5 | 4.346665e-06 | 5 |
| REAC | REAC:R-HSA-1236975 | Antigen processing-Cross presentation | Antigen processing-Cross presentation | 5 | 4.790848e-06 | 5 |
| REAC | REAC:R-HSA-5610787 | Hedgehog 'off' state | Hedgehog 'off' state | 5 | 6.942949e-06 | 5 |
| REAC | REAC:R-HSA-9020702 | Interleukin-1 signaling | Interleukin-1 signaling | 5 | 6.942949e-06 | 5 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 5 | 8.637837e-06 | 5 |
| REAC | REAC:R-HSA-202403 | TCR signaling | TCR signaling | 5 | 9.401538e-06 | 5 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 5 | 9.803033e-06 | 5 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 5 | 1.109008e-05 | 5 |
| REAC | REAC:R-HSA-9758941 | Gastrulation | Gastrulation | 5 | 1.154776e-05 | 5 |
| REAC | REAC:R-HSA-162909 | Host Interactions of HIV factors | Host Interactions of HIV factors | 5 | 1.250820e-05 | 5 |
| REAC | REAC:R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5 | 1.353119e-05 | 5 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 5 | 1.461969e-05 | 5 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 6 | 1.645838e-05 | 5 |
| REAC | REAC:R-HSA-2871837 | FCERI mediated NF-kB activation | FCERI mediated NF-kB activation | 5 | 1.764791e-05 | 5 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 5 | 1.764791e-05 | 5 |
| REAC | REAC:R-HSA-6807070 | PTEN Regulation | PTEN Regulation | 5 | 1.899045e-05 | 5 |
| REAC | REAC:R-HSA-68867 | Assembly of the pre-replicative complex | Assembly of the pre-replicative complex | 5 | 2.191913e-05 | 5 |
| REAC | REAC:R-HSA-3858494 | Beta-catenin independent WNT signaling | Beta-catenin independent WNT signaling | 5 | 2.270462e-05 | 5 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 5 | 2.697490e-05 | 5 |
| REAC | REAC:R-HSA-5358351 | Signaling by Hedgehog | Signaling by Hedgehog | 5 | 2.790085e-05 | 5 |
| REAC | REAC:R-HSA-446652 | Interleukin-1 family signaling | Interleukin-1 family signaling | 5 | 2.982857e-05 | 5 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 5 | 3.862597e-05 | 5 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 5 | 4.241168e-05 | 5 |
| REAC | REAC:R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | Signaling by the B Cell Receptor (BCR) | 5 | 4.373707e-05 | 5 |
| REAC | REAC:R-HSA-5619115 | Disorders of transmembrane transporters | Disorders of transmembrane transporters | 5 | 5.889070e-05 | 5 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 5 | 6.416758e-05 | 5 |
| REAC | REAC:R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | Fc epsilon receptor (FCERI) signaling | 5 | 7.584688e-05 | 5 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 5 | 8.681698e-05 | 5 |
| REAC | REAC:R-HSA-2467813 | Separation of Sister Chromatids | Separation of Sister Chromatids | 5 | 8.915483e-05 | 5 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 5 | 1.097137e-04 | 5 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 5 | 1.153985e-04 | 5 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 5 | 1.474327e-04 | 5 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 5 | 1.546115e-04 | 5 |
| REAC | REAC:R-HSA-5689880 | Ub-specific processing proteases | Ub-specific processing proteases | 5 | 1.992116e-04 | 5 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 5 | 2.225878e-04 | 5 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 5 | 2.325252e-04 | 5 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 5 | 2.376241e-04 | 5 |
| REAC | REAC:R-HSA-157118 | Signaling by NOTCH | Signaling by NOTCH | 5 | 2.480877e-04 | 5 |
| REAC | REAC:R-HSA-201681 | TCF dependent signaling in response to WNT | TCF dependent signaling in response to WNT | 5 | 2.480877e-04 | 5 |
| REAC | REAC:R-HSA-8878171 | Transcriptional regulation by RUNX1 | Transcriptional regulation by RUNX1 | 5 | 2.644646e-04 | 5 |
| REAC | REAC:R-HSA-1280218 | Adaptive Immune System | Adaptive Immune System | 7 | 3.091911e-04 | 5 |
| REAC | REAC:R-HSA-8951664 | Neddylation | Neddylation | 5 | 3.253390e-04 | 5 |
| REAC | REAC:R-HSA-1257604 | PIP3 activates AKT signaling | PIP3 activates AKT signaling | 5 | 3.816134e-04 | 5 |
| REAC | REAC:R-HSA-5673001 | RAF/MAP kinase cascade | RAF/MAP kinase cascade | 5 | 4.984290e-04 | 5 |
| REAC | REAC:R-HSA-5684996 | MAPK1/MAPK3 signaling | MAPK1/MAPK3 signaling | 5 | 5.463975e-04 | 5 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 6 | 6.839017e-04 | 5 |
| REAC | REAC:R-HSA-9006925 | Intracellular signaling by second messengers | Intracellular signaling by second messengers | 5 | 7.892616e-04 | 5 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 5 | 8.723360e-04 | 5 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 6 | 8.897953e-04 | 5 |
| REAC | REAC:R-HSA-5683057 | MAPK family signaling cascades | MAPK family signaling cascades | 5 | 1.059171e-03 | 5 |
| REAC | REAC:R-HSA-195721 | Signaling by WNT | Signaling by WNT | 5 | 1.376494e-03 | 5 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 5 | 2.295282e-03 | 5 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 6 | 2.515172e-03 | 5 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 6 | 3.257628e-03 | 5 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 5 | 4.010054e-03 | 5 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 6 | 5.606993e-03 | 5 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 5 | 6.119623e-03 | 5 |
| REAC | REAC:R-HSA-449147 | Signaling by Interleukins | Signaling by Interleukins | 5 | 8.571884e-03 | 5 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 8 | 1.407300e-02 | 5 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 5 | 1.704871e-02 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03050 | Proteasome | Proteasome | 5 | 2.510928e-08 | 5 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | Spinocerebellar ataxia | 5 | 7.626108e-06 | 5 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 5 | 4.156101e-05 | 5 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 5 | 1.760077e-04 | 5 |
| KEGG | KEGG:05020 | Prion disease | Prion disease | 5 | 1.965470e-04 | 5 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 5 | 3.515343e-04 | 5 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 5 | 8.243148e-04 | 5 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 5 | 1.057114e-03 | 5 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 5 | 3.010177e-03 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:32 | PA700 complex | PA700 complex | 5 | 3.643985e-08 | 5 |
| CORUM | CORUM:193 | PA700-20S-PA28 complex | PA700-20S-PA28 complex | 5 | 5.524538e-07 | 5 |
| CORUM | CORUM:6860 | E6AP-HERC2-MAPK6-NEURL4 complex | E6AP-HERC2-MAPK6-NEURL4 complex | 2 | 4.577786e-03 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 7 | 1.446832e-07 | 5 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 7 | 9.619762e-07 | 5 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 7 | 2.647604e-06 | 5 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 7 | 2.954970e-06 | 5 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 7 | 3.119742e-06 | 5 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 7 | 1.256644e-05 | 5 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 7 | 8.131012e-05 | 5 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 7 | 7.248173e-04 | 5 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 7 | 1.002531e-03 | 5 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 8 | 2.522115e-03 | 5 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 6 | 2.969488e-03 | 5 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 9 | 1.338291e-02 | 5 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 4 | 2.096243e-02 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP183 | Proteasome degradation | Proteasome degradation | 5 | 2.315739e-07 | 5 |
| WP | WP:WP2359 | Parkin ubiquitin proteasomal system pathway | Parkin ubiquitin proteasomal system pathway | 5 | 4.643316e-07 | 5 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 5 | 3.157745e-04 | 5 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 5 | 3.469060e-04 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0036402 | proteasome-activating activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome." [GOC:rb, PMID:11430818] | 2 | 0.000801 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 6 | 0.029802 | 5 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 7 | 0.034021 | 5 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 10 | 0.040232 | 5 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-320d | hsa-mir-320d | hsa-mir-320d | 5 | 0.023263 | 6 |
| MIRNA | MIRNA:hsa-mir-4429 | hsa-mir-4429 | hsa-mir-4429 | 5 | 0.023350 | 6 |
| MIRNA | MIRNA:hsa-mir-320c | hsa-mir-320c | hsa-mir-320c | 5 | 0.024962 | 6 |
| MIRNA | MIRNA:hsa-mir-320b | hsa-mir-320b | hsa-mir-320b | 5 | 0.028247 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 4 | 0.024480 | 6 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 4 | 0.032308 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3965 | Lipid metabolism pathway | Lipid metabolism pathway | 2 | 0.026109 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004312 | fatty acid synthase activity | "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] | 1 | 0.049963 | 6 |
| GO:MF | GO:0004313 | [acyl-carrier-protein] S-acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [RHEA:41788] | 1 | 0.049963 | 6 |
| GO:MF | GO:0031177 | phosphopantetheine binding | "Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [GOC:mah, GOC:vw] | 1 | 0.049963 | 6 |
| GO:MF | GO:0140778 | microtubule stabilizing activity | "A protein-containing complex stabilizing activity that prevents dissociation of microtubules." [PMID:34970964] | 1 | 0.049963 | 6 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5357905 | Regulation of TNFR1 signaling | Regulation of TNFR1 signaling | 8 | 1.236535e-16 | 7 |
| REAC | REAC:R-HSA-75893 | TNF signaling | TNF signaling | 8 | 5.765715e-16 | 7 |
| REAC | REAC:R-HSA-73887 | Death Receptor Signaling | Death Receptor Signaling | 9 | 4.306311e-15 | 7 |
| REAC | REAC:R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | TNFR1-induced NF-kappa-B signaling pathway | 6 | 1.054572e-11 | 7 |
| REAC | REAC:R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | TICAM1, RIP1-mediated IKK complex recruitment | 5 | 3.050738e-10 | 7 |
| REAC | REAC:R-HSA-937041 | IKK complex recruitment mediated by RIP1 | IKK complex recruitment mediated by RIP1 | 5 | 6.902738e-10 | 7 |
| REAC | REAC:R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6 | 3.295941e-09 | 7 |
| REAC | REAC:R-HSA-5213460 | RIPK1-mediated regulated necrosis | RIPK1-mediated regulated necrosis | 5 | 4.441602e-09 | 7 |
| REAC | REAC:R-HSA-5675482 | Regulation of necroptotic cell death | Regulation of necroptotic cell death | 5 | 4.441602e-09 | 7 |
| REAC | REAC:R-HSA-168638 | NOD1/2 Signaling Pathway | NOD1/2 Signaling Pathway | 5 | 9.839902e-09 | 7 |
| REAC | REAC:R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | Toll Like Receptor 3 (TLR3) Cascade | 6 | 1.339219e-08 | 7 |
| REAC | REAC:R-HSA-5689896 | Ovarian tumor domain proteases | Ovarian tumor domain proteases | 5 | 1.501420e-08 | 7 |
| REAC | REAC:R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | TRIF (TICAM1)-mediated TLR4 signaling | 6 | 1.691111e-08 | 7 |
| REAC | REAC:R-HSA-166166 | MyD88-independent TLR4 cascade | MyD88-independent TLR4 cascade | 6 | 1.691111e-08 | 7 |
| REAC | REAC:R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 5 | 9.027660e-08 | 7 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 7 | 9.619818e-08 | 7 |
| REAC | REAC:R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | Toll Like Receptor 4 (TLR4) Cascade | 6 | 9.908304e-08 | 7 |
| REAC | REAC:R-HSA-5218859 | Regulated Necrosis | Regulated Necrosis | 5 | 1.188011e-07 | 7 |
| REAC | REAC:R-HSA-9758274 | Regulation of NF-kappa B signaling | Regulation of NF-kappa B signaling | 4 | 1.764719e-07 | 7 |
| REAC | REAC:R-HSA-168898 | Toll-like Receptor Cascades | Toll-like Receptor Cascades | 6 | 2.359669e-07 | 7 |
| REAC | REAC:R-HSA-5357786 | TNFR1-induced proapoptotic signaling | TNFR1-induced proapoptotic signaling | 4 | 7.276755e-07 | 7 |
| REAC | REAC:R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | TAK1-dependent IKK and NF-kappa-B activation | 4 | 7.755034e-06 | 7 |
| REAC | REAC:R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 3 | 3.851178e-05 | 7 |
| REAC | REAC:R-HSA-937039 | IRAK1 recruits IKK complex | IRAK1 recruits IKK complex | 3 | 3.851178e-05 | 7 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 5 | 7.654849e-05 | 7 |
| REAC | REAC:R-HSA-5689880 | Ub-specific processing proteases | Ub-specific processing proteases | 5 | 1.035358e-04 | 7 |
| REAC | REAC:R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | 3 | 1.624017e-04 | 7 |
| REAC | REAC:R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | Toll Like Receptor 5 (TLR5) Cascade | 4 | 1.785107e-04 | 7 |
| REAC | REAC:R-HSA-975871 | MyD88 cascade initiated on plasma membrane | MyD88 cascade initiated on plasma membrane | 4 | 1.785107e-04 | 7 |
| REAC | REAC:R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | Toll Like Receptor 10 (TLR10) Cascade | 4 | 1.785107e-04 | 7 |
| REAC | REAC:R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | activated TAK1 mediates p38 MAPK activation | 3 | 1.866855e-04 | 7 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 4 | 1.941416e-04 | 7 |
| REAC | REAC:R-HSA-202424 | Downstream TCR signaling | Downstream TCR signaling | 4 | 2.023290e-04 | 7 |
| REAC | REAC:R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4 | 2.194728e-04 | 7 |
| REAC | REAC:R-HSA-975155 | MyD88 dependent cascade initiated on endosome | MyD88 dependent cascade initiated on endosome | 4 | 2.284396e-04 | 7 |
| REAC | REAC:R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4 | 2.376767e-04 | 7 |
| REAC | REAC:R-HSA-933542 | TRAF6 mediated NF-kB activation | TRAF6 mediated NF-kB activation | 3 | 2.422502e-04 | 7 |
| REAC | REAC:R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | Toll Like Receptor 9 (TLR9) Cascade | 4 | 2.670627e-04 | 7 |
| REAC | REAC:R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4 | 3.338608e-04 | 7 |
| REAC | REAC:R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | Toll Like Receptor TLR6:TLR2 Cascade | 4 | 3.338608e-04 | 7 |
| REAC | REAC:R-HSA-9020702 | Interleukin-1 signaling | Interleukin-1 signaling | 4 | 3.586689e-04 | 7 |
| REAC | REAC:R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | Toll Like Receptor 2 (TLR2) Cascade | 4 | 3.715753e-04 | 7 |
| REAC | REAC:R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | Toll Like Receptor TLR1:TLR2 Cascade | 4 | 3.715753e-04 | 7 |
| REAC | REAC:R-HSA-202403 | TCR signaling | TCR signaling | 4 | 4.564197e-04 | 7 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 9 | 5.508102e-04 | 7 |
| REAC | REAC:R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | Negative regulators of DDX58/IFIH1 signaling | 3 | 6.865417e-04 | 7 |
| REAC | REAC:R-HSA-2871837 | FCERI mediated NF-kB activation | FCERI mediated NF-kB activation | 4 | 7.530975e-04 | 7 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 4 | 7.530975e-04 | 7 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 7 | 8.266107e-04 | 7 |
| REAC | REAC:R-HSA-446652 | Interleukin-1 family signaling | Interleukin-1 family signaling | 4 | 1.143270e-03 | 7 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 4 | 2.102769e-03 | 7 |
| REAC | REAC:R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | Fc epsilon receptor (FCERI) signaling | 4 | 2.401946e-03 | 7 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 6 | 2.439810e-03 | 7 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 8 | 3.456832e-03 | 7 |
| REAC | REAC:R-HSA-450294 | MAP kinase activation | MAP kinase activation | 3 | 3.923480e-03 | 7 |
| REAC | REAC:R-HSA-8948751 | Regulation of PTEN stability and activity | Regulation of PTEN stability and activity | 3 | 5.419811e-03 | 7 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 7 | 5.423826e-03 | 7 |
| REAC | REAC:R-HSA-448424 | Interleukin-17 signaling | Interleukin-17 signaling | 3 | 5.660166e-03 | 7 |
| REAC | REAC:R-HSA-8948747 | Regulation of PTEN localization | Regulation of PTEN localization | 2 | 5.995612e-03 | 7 |
| REAC | REAC:R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | IRAK2 mediated activation of TAK1 complex | 2 | 7.491335e-03 | 7 |
| REAC | REAC:R-HSA-1257604 | PIP3 activates AKT signaling | PIP3 activates AKT signaling | 4 | 8.683624e-03 | 7 |
| REAC | REAC:R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | TICAM1,TRAF6-dependent induction of TAK1 complex | 2 | 9.152192e-03 | 7 |
| REAC | REAC:R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | Alpha-protein kinase 1 signaling pathway | 2 | 9.152192e-03 | 7 |
| REAC | REAC:R-HSA-170834 | Signaling by TGF-beta Receptor Complex | Signaling by TGF-beta Receptor Complex | 3 | 1.286833e-02 | 7 |
| REAC | REAC:R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2 | 1.296846e-02 | 7 |
| REAC | REAC:R-HSA-209543 | p75NTR recruits signalling complexes | p75NTR recruits signalling complexes | 2 | 1.296846e-02 | 7 |
| REAC | REAC:R-HSA-209560 | NF-kB is activated and signals survival | NF-kB is activated and signals survival | 2 | 1.296846e-02 | 7 |
| REAC | REAC:R-HSA-9006925 | Intracellular signaling by second messengers | Intracellular signaling by second messengers | 4 | 1.547524e-02 | 7 |
| REAC | REAC:R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | TNFR2 non-canonical NF-kB pathway | 3 | 1.651521e-02 | 7 |
| REAC | REAC:R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2 | 1.744274e-02 | 7 |
| REAC | REAC:R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2 | 1.744274e-02 | 7 |
| REAC | REAC:R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2 | 1.992610e-02 | 7 |
| REAC | REAC:R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 2 | 1.992610e-02 | 7 |
| REAC | REAC:R-HSA-205043 | NRIF signals cell death from the nucleus | NRIF signals cell death from the nucleus | 2 | 1.992610e-02 | 7 |
| REAC | REAC:R-HSA-193639 | p75NTR signals via NF-kB | p75NTR signals via NF-kB | 2 | 1.992610e-02 | 7 |
| REAC | REAC:R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3 | 2.844868e-02 | 7 |
| REAC | REAC:R-HSA-9006936 | Signaling by TGFB family members | Signaling by TGFB family members | 3 | 2.988279e-02 | 7 |
| REAC | REAC:R-HSA-6807070 | PTEN Regulation | PTEN Regulation | 3 | 4.308975e-02 | 7 |
| REAC | REAC:R-HSA-983169 | Class I MHC mediated antigen processing & presentation | Class I MHC mediated antigen processing & presentation | 4 | 4.316571e-02 | 7 |
| REAC | REAC:R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | APC/C:Cdc20 mediated degradation of Cyclin B | 2 | 4.567470e-02 | 7 |
| REAC | REAC:R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | Downregulation of TGF-beta receptor signaling | 2 | 4.962535e-02 | 7 |
| REAC | REAC:R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | Inactivation of CSF3 (G-CSF) signaling | 2 | 4.962535e-02 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000209 | protein polyubiquitination | "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [PMID:26906419] | 7 | 9.294147e-09 | 7 |
| GO:BP | GO:0070534 | protein K63-linked ubiquitination | "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404] | 5 | 9.499472e-08 | 7 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 6 | 1.483636e-07 | 7 |
| GO:BP | GO:0016567 | protein ubiquitination | "The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419] | 8 | 1.499244e-07 | 7 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] | 8 | 3.458850e-07 | 7 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 6 | 4.762440e-07 | 7 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 6 | 5.394992e-07 | 7 |
| GO:BP | GO:0031398 | positive regulation of protein ubiquitination | "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 5 | 9.349277e-07 | 7 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] | 8 | 1.001180e-06 | 7 |
| GO:BP | GO:0033209 | tumor necrosis factor-mediated signaling pathway | "The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] | 5 | 1.124295e-06 | 7 |
| GO:BP | GO:0043122 | regulation of canonical NF-kappaB signal transduction | "Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372] | 6 | 1.431934e-06 | 7 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 8 | 1.512449e-06 | 7 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 8 | 1.658512e-06 | 7 |
| GO:BP | GO:0007249 | canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217] | 6 | 2.187755e-06 | 7 |
| GO:BP | GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 5 | 2.484689e-06 | 7 |
| GO:BP | GO:1901875 | positive regulation of post-translational protein modification | "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 5 | 2.581997e-06 | 7 |
| GO:BP | GO:0071356 | cellular response to tumor necrosis factor | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] | 5 | 2.541390e-05 | 7 |
| GO:BP | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | "Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade." [GOC:jl] | 5 | 2.930199e-05 | 7 |
| GO:BP | GO:0070424 | regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | "Any process that modulates the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway." [GOC:add] | 3 | 4.086351e-05 | 7 |
| GO:BP | GO:0034612 | response to tumor necrosis factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] | 5 | 4.111990e-05 | 7 |
| GO:BP | GO:0023035 | CD40 signaling pathway | "The series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mtg_signal, GOC:signaling, PMID:11348017] | 3 | 5.028099e-05 | 7 |
| GO:BP | GO:1902916 | positive regulation of protein polyubiquitination | "Any process that activates or increases the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667] | 3 | 6.104023e-05 | 7 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 7 | 8.131012e-05 | 7 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 7 | 9.221429e-05 | 7 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 9 | 1.540985e-04 | 7 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 8 | 1.609975e-04 | 7 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 6 | 1.662733e-04 | 7 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 6 | 1.678238e-04 | 7 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 6 | 1.757568e-04 | 7 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 8 | 2.041245e-04 | 7 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 9 | 2.216159e-04 | 7 |
| GO:BP | GO:1902914 | regulation of protein polyubiquitination | "Any process that modulates the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667] | 3 | 2.619076e-04 | 7 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 9 | 2.685898e-04 | 7 |
| GO:BP | GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number." [GOC:sj, PMID:18280719, PMID:32838963, PMID:36973360] | 3 | 3.270195e-04 | 7 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 10 | 3.758912e-04 | 7 |
| GO:BP | GO:0050778 | positive regulation of immune response | "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 6 | 4.716082e-04 | 7 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 6 | 5.749401e-04 | 7 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 7 | 7.248173e-04 | 7 |
| GO:BP | GO:0002753 | cytoplasmic pattern recognition receptor signaling pathway | "The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967, PMID:17328678, PMID:18272355, PMID:19531363, PMID:21187438] | 4 | 1.064230e-03 | 7 |
| GO:BP | GO:0050776 | regulation of immune response | "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 6 | 1.717157e-03 | 7 |
| GO:BP | GO:0002757 | immune response-activating signaling pathway | "The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add] | 5 | 1.865000e-03 | 7 |
| GO:BP | GO:0045087 | innate immune response | "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] | 6 | 2.148917e-03 | 7 |
| GO:BP | GO:0019221 | cytokine-mediated signaling pathway | "The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629] | 5 | 2.355048e-03 | 7 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 8 | 2.522115e-03 | 7 |
| GO:BP | GO:0002764 | immune response-regulating signaling pathway | "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] | 5 | 2.888909e-03 | 7 |
| GO:BP | GO:0002253 | activation of immune response | "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] | 5 | 3.453335e-03 | 7 |
| GO:BP | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway | "Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb] | 3 | 3.523909e-03 | 7 |
| GO:BP | GO:0032623 | interleukin-2 production | "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] | 3 | 3.696291e-03 | 7 |
| GO:BP | GO:0032663 | regulation of interleukin-2 production | "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah] | 3 | 3.696291e-03 | 7 |
| GO:BP | GO:0140546 | defense response to symbiont | "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] | 6 | 3.741013e-03 | 7 |
| GO:BP | GO:0002684 | positive regulation of immune system process | "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] | 6 | 4.096840e-03 | 7 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 8 | 4.205780e-03 | 7 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 7 | 5.764744e-03 | 7 |
| GO:BP | GO:0002221 | pattern recognition receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] | 4 | 5.846214e-03 | 7 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 5 | 6.052902e-03 | 7 |
| GO:BP | GO:0051865 | protein autoubiquitination | "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai] | 3 | 6.218091e-03 | 7 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 7 | 6.399553e-03 | 7 |
| GO:BP | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway | "The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 1 (NOD1) protein receptor, and ending with regulation of a downstream cellular process." [GOC:add, PMID:17944960, PMID:18585455] | 2 | 6.618328e-03 | 7 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 7 | 7.189473e-03 | 7 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 7 | 7.287596e-03 | 7 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 8 | 7.422063e-03 | 7 |
| GO:BP | GO:0002758 | innate immune response-activating signaling pathway | "The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an innate immune response." [GOC:jy, GOC:mah, PMID:11418339, PMID:28105028] | 4 | 7.464357e-03 | 7 |
| GO:BP | GO:0098542 | defense response to other organism | "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] | 6 | 9.193755e-03 | 7 |
| GO:BP | GO:0002218 | activation of innate immune response | "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805] | 4 | 9.895877e-03 | 7 |
| GO:BP | GO:0051090 | regulation of DNA-binding transcription factor activity | "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] | 4 | 1.225832e-02 | 7 |
| GO:BP | GO:0097400 | interleukin-17-mediated signaling pathway | "The series of molecular signals initiated by interleukin-17 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ic, PMID:21602493] | 2 | 1.299040e-02 | 7 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 8 | 1.378548e-02 | 7 |
| GO:BP | GO:0070936 | protein K48-linked ubiquitination | "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404] | 3 | 1.379381e-02 | 7 |
| GO:BP | GO:0000165 | MAPK cascade | "An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267] | 5 | 1.383194e-02 | 7 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 7 | 2.100693e-02 | 7 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 8 | 2.121702e-02 | 7 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 6 | 2.140900e-02 | 7 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 8 | 2.159391e-02 | 7 |
| GO:BP | GO:0045089 | positive regulation of innate immune response | "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] | 4 | 2.210121e-02 | 7 |
| GO:BP | GO:0030522 | intracellular receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a receptor located within a cell." [GOC:bf, GOC:mah] | 4 | 2.280605e-02 | 7 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 6 | 2.351237e-02 | 7 |
| GO:BP | GO:0039531 | regulation of cytoplasmic pattern recognition receptor signaling pathway | "Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway." [GOC:bf, GOC:jl] | 3 | 2.396028e-02 | 7 |
| GO:BP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030] | 3 | 2.456849e-02 | 7 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 6 | 2.539158e-02 | 7 |
| GO:BP | GO:0038061 | non-canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217] | 3 | 2.581530e-02 | 7 |
| GO:BP | GO:0009605 | response to external stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] | 7 | 2.661267e-02 | 7 |
| GO:BP | GO:0071345 | cellular response to cytokine stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah] | 5 | 2.699745e-02 | 7 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 8 | 2.745123e-02 | 7 |
| GO:BP | GO:0002833 | positive regulation of response to biotic stimulus | "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] | 4 | 2.877510e-02 | 7 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 5 | 3.019481e-02 | 7 |
| GO:BP | GO:0097398 | cellular response to interleukin-17 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr] | 2 | 3.207284e-02 | 7 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] | 6 | 3.320189e-02 | 7 |
| GO:BP | GO:0002682 | regulation of immune system process | "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] | 6 | 3.356555e-02 | 7 |
| GO:BP | GO:0051707 | response to other organism | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] | 6 | 3.492693e-02 | 7 |
| GO:BP | GO:0043207 | response to external biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] | 6 | 3.530594e-02 | 7 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 5 | 3.573017e-02 | 7 |
| GO:BP | GO:0097396 | response to interleukin-17 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr] | 2 | 3.607280e-02 | 7 |
| GO:BP | GO:0070431 | nucleotide-binding oligomerization domain containing 2 signaling pathway | "The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process." [GOC:add, PMID:17944960, PMID:18585455] | 2 | 4.030643e-02 | 7 |
| GO:BP | GO:0009607 | response to biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] | 6 | 4.054627e-02 | 7 |
| GO:BP | GO:0034097 | response to cytokine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] | 5 | 4.446516e-02 | 7 |
| GO:BP | GO:0045088 | regulation of innate immune response | "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] | 4 | 4.524346e-02 | 7 |
| GO:BP | GO:1901652 | response to peptide | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] | 5 | 4.796025e-02 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | NF-kappa B signaling pathway | 6 | 3.227081e-08 | 7 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | Ubiquitin mediated proteolysis | 6 | 2.213716e-07 | 7 |
| KEGG | KEGG:04621 | NOD-like receptor signaling pathway | NOD-like receptor signaling pathway | 6 | 1.077179e-06 | 7 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 5 | 1.990785e-06 | 7 |
| KEGG | KEGG:04668 | TNF signaling pathway | TNF signaling pathway | 5 | 5.623383e-06 | 7 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | IL-17 signaling pathway | 4 | 1.587408e-04 | 7 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 5 | 2.701747e-04 | 7 |
| KEGG | KEGG:05145 | Toxoplasmosis | Toxoplasmosis | 4 | 3.016943e-04 | 7 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 4 | 7.335523e-04 | 7 |
| KEGG | KEGG:04217 | Necroptosis | Necroptosis | 4 | 1.367301e-03 | 7 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 4 | 3.321308e-03 | 7 |
| KEGG | KEGG:04622 | RIG-I-like receptor signaling pathway | RIG-I-like receptor signaling pathway | 3 | 3.964893e-03 | 7 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 4 | 8.117509e-03 | 7 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 5 | 1.080167e-02 | 7 |
| KEGG | KEGG:04010 | MAPK signaling pathway | MAPK signaling pathway | 4 | 1.689148e-02 | 7 |
| KEGG | KEGG:04380 | Osteoclast differentiation | Osteoclast differentiation | 3 | 2.502219e-02 | 7 |
| KEGG | KEGG:05135 | Yersinia infection | Yersinia infection | 3 | 2.731689e-02 | 7 |
| KEGG | KEGG:05162 | Measles | Measles | 3 | 2.851351e-02 | 7 |
| KEGG | KEGG:04215 | Apoptosis - multiple species | Apoptosis - multiple species | 2 | 3.734139e-02 | 7 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 3 | 4.238128e-02 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004842 | ubiquitin-protein transferase activity | "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] | 7 | 8.827782e-08 | 7 |
| GO:MF | GO:0019787 | ubiquitin-like protein transferase activity | "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] | 7 | 1.341805e-07 | 7 |
| GO:MF | GO:0016755 | aminoacyltransferase activity | "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] | 7 | 1.704889e-07 | 7 |
| GO:MF | GO:0061630 | ubiquitin protein ligase activity | "Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777] | 6 | 1.064556e-06 | 7 |
| GO:MF | GO:0061659 | ubiquitin-like protein ligase activity | "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] | 6 | 1.472012e-06 | 7 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 9 | 2.307924e-06 | 7 |
| GO:MF | GO:0016746 | acyltransferase activity | "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-] | 7 | 2.358862e-06 | 7 |
| GO:MF | GO:0016740 | transferase activity | "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-] | 9 | 1.468476e-05 | 7 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 5 | 3.263571e-05 | 7 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 5 | 4.334903e-05 | 7 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 6 | 1.200107e-04 | 7 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 8 | 9.488499e-04 | 7 |
| GO:MF | GO:0043130 | ubiquitin binding | "Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd] | 3 | 2.469681e-03 | 7 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 7 | 2.698377e-03 | 7 |
| GO:MF | GO:0034450 | ubiquitin-ubiquitin ligase activity | "Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603] | 2 | 4.147414e-03 | 7 |
| GO:MF | GO:0032182 | ubiquitin-like protein binding | "Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah] | 3 | 4.161492e-03 | 7 |
| GO:MF | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | "Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase] | 2 | 6.747245e-03 | 7 |
| GO:MF | GO:0070530 | K63-linked polyubiquitin modification-dependent protein binding | "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein." [GOC:mah, PMID:15556404, PMID:17525341] | 2 | 1.181857e-02 | 7 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 5 | 1.261954e-02 | 7 |
| GO:MF | GO:0005164 | tumor necrosis factor receptor binding | "Binding to a tumor necrosis factor receptor." [GOC:ai] | 2 | 1.950403e-02 | 7 |
| GO:MF | GO:0046872 | metal ion binding | "Binding to a metal ion." [GOC:ai] | 8 | 2.603917e-02 | 7 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 5 | 2.691459e-02 | 7 |
| GO:MF | GO:0043169 | cation binding | "Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl] | 8 | 3.078864e-02 | 7 |
| GO:MF | GO:0043028 | cysteine-type endopeptidase regulator activity involved in apoptotic process | "Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase] | 2 | 3.216818e-02 | 7 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 9 | 3.932783e-02 | 7 |
| GO:MF | GO:0032813 | tumor necrosis factor receptor superfamily binding | "Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add] | 2 | 4.794227e-02 | 7 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 4 | 4.984915e-02 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0035631 | CD40 receptor complex | "A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules." [GOC:BHF, PMID:20614026, PMID:9221764] | 3 | 0.000001 | 7 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 10 | 0.000104 | 7 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 4 | 0.000962 | 7 |
| GO:CC | GO:0009898 | cytoplasmic side of plasma membrane | "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] | 3 | 0.005186 | 7 |
| GO:CC | GO:0098562 | cytoplasmic side of membrane | "The side of a membrane that faces the cytoplasm." [GOC:dos] | 3 | 0.010619 | 7 |
| GO:CC | GO:0098802 | plasma membrane signaling receptor complex | "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." [GOC:dos] | 3 | 0.034148 | 7 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 10 | 0.041974 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5529 | TRAF2-cIAP1/BIRC2 complex | TRAF2-cIAP1/BIRC2 complex | 2 | 0.000074 | 7 |
| CORUM | CORUM:5531 | Tumor necrosis factor receptor 1 signaling complex | Tumor necrosis factor receptor 1 signaling complex | 2 | 0.000221 | 7 |
| CORUM | CORUM:6344 | TNF-R1-associated signaling complex | TNF-R1-associated signaling complex | 2 | 0.006639 | 7 |
| CORUM | CORUM:5827 | IKBKG homotetramer complex | IKBKG homotetramer complex | 1 | 0.049819 | 7 |
| CORUM | CORUM:2074 | TRAF6 homo-oligomer complex | TRAF6 homo-oligomer complex | 1 | 0.049819 | 7 |
| CORUM | CORUM:5730 | IKBKG homotrimer complex | IKBKG homotrimer complex | 1 | 0.049819 | 7 |
| CORUM | CORUM:2123 | IKBKG homodimer complex | IKBKG homodimer complex | 1 | 0.049819 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0000554 | Uveitis | Inflammation of one or all portions of the uveal tract. | 4 | 0.000104 | 7 |
| HP | HP:0012122 | Anterior uveitis | Inflammation of the uveal tract in which the primary site of inflammation is the anterior chamber. | 3 | 0.000365 | 7 |
| HP | HP:0002961 | Dysgammaglobulinemia | Selective deficiency of one or more, but not all, classes of immunoglobulins. | 2 | 0.007591 | 7 |
| HP | HP:0100533 | Inflammatory abnormality of the eye | Inflammation of the eye, parts of the eye or the periorbital region. | 4 | 0.017434 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4519 | hsa-mir-4519 | hsa-mir-4519 | 7 | 0.000222 | 7 |
| MIRNA | MIRNA:hsa-mir-125b-5p | hsa-mir-125b-5p | hsa-mir-125b-5p | 4 | 0.033552 | 7 |
| MIRNA | MIRNA:hsa-mir-3065-5p | hsa-mir-3065-5p | hsa-mir-3065-5p | 6 | 0.041601 | 7 |
| MIRNA | MIRNA:hsa-mir-466 | hsa-mir-466 | hsa-mir-466 | 6 | 0.049812 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP254 | Apoptosis | Apoptosis | 4 | 0.000242 | 7 |
| WP | WP:WP231 | TNF alpha signaling | TNF alpha signaling | 4 | 0.000266 | 7 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 4 | 0.000345 | 7 |
| WP | WP:WP2018 | RANKL RANK signaling | RANKL RANK signaling | 3 | 0.002715 | 7 |
| WP | WP:WP195 | IL1 signaling | IL1 signaling | 3 | 0.003428 | 7 |
| WP | WP:WP3865 | Novel intracellular components of RIG I like receptor pathway | Novel intracellular components of RIG I like receptor pathway | 3 | 0.004712 | 7 |
| WP | WP:WP5072 | Modulators of TCR signaling and T cell activation | Modulators of TCR signaling and T cell activation | 3 | 0.004953 | 7 |
| WP | WP:WP3849 | MAPK and NFkB signaling inhibited by Yersinia YopJ | MAPK and NFkB signaling inhibited by Yersinia YopJ | 2 | 0.010224 | 7 |
| WP | WP:WP382 | MAPK signaling | MAPK signaling | 4 | 0.014613 | 7 |
| WP | WP:WP1772 | Apoptosis modulation and signaling | Apoptosis modulation and signaling | 3 | 0.015886 | 7 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 5 | 0.016449 | 7 |
| WP | WP:WP262 | Ebstein Barr virus LMP1 signaling | Ebstein Barr virus LMP1 signaling | 2 | 0.038928 | 7 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 6 | 0.000002 | 8 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 6 | 0.000004 | 8 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 6 | 0.000077 | 8 |
| GO:CC | GO:0034451 | centriolar satellite | "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812] | 3 | 0.001047 | 8 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 6 | 0.001929 | 8 |
| GO:CC | GO:0005814 | centriole | "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] | 3 | 0.002075 | 8 |
| GO:CC | GO:0005929 | cilium | "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] | 4 | 0.008095 | 8 |
| GO:CC | GO:0005819 | spindle | "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] | 3 | 0.039964 | 8 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 5 | 0.044282 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0035735 | intraciliary transport involved in cilium assembly | "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia] | 2 | 0.001272 | 8 |
| GO:BP | GO:0034453 | microtubule anchoring | "Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah] | 2 | 0.019632 | 8 |
| GO:BP | GO:0071539 | protein localization to centrosome | "A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd] | 2 | 0.040175 | 8 |
| GO:BP | GO:1905508 | protein localization to microtubule organizing center | "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497] | 2 | 0.042402 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | Loss of proteins required for interphase microtubule organization from the centrosome | 2 | 0.020593 | 8 |
| REAC | REAC:R-HSA-380259 | Loss of Nlp from mitotic centrosomes | Loss of Nlp from mitotic centrosomes | 2 | 0.020593 | 8 |
| REAC | REAC:R-HSA-8854518 | AURKA Activation by TPX2 | AURKA Activation by TPX2 | 2 | 0.022460 | 8 |
| REAC | REAC:R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | Recruitment of mitotic centrosome proteins and complexes | 2 | 0.028545 | 8 |
| REAC | REAC:R-HSA-380287 | Centrosome maturation | Centrosome maturation | 2 | 0.028545 | 8 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 2 | 0.032239 | 8 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 2 | 0.039450 | 8 |
| REAC | REAC:R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | Anchoring of the basal body to the plasma membrane | 2 | 0.041151 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4656 | Joubert syndrome | Joubert syndrome | 2 | 0.037291 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-144 | hsa-mir-144 | hsa-mir-144 | 5 | 0.043352 | 8 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 8 | 0.00209 | 9 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 5 | 0.04731 | 9 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M10980_1 | Factor: lhx6; motif: CTCGTTAR; match class: 1 | Factor: lhx6; motif: CTCGTTAR; match class: 1 | 2 | 0.004974 | 9 |
| TF | TF:M10974_1 | Factor: LHX9; motif: NTCGTTAN; match class: 1 | Factor: LHX9; motif: NTCGTTAN; match class: 1 | 2 | 0.004974 | 9 |
| TF | TF:M10985_1 | Factor: LHX8; motif: CTCGTTAN; match class: 1 | Factor: LHX8; motif: CTCGTTAN; match class: 1 | 2 | 0.021283 | 9 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140142 | nucleocytoplasmic carrier activity | "Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein." [GOC:pg] | 2 | 0.009006 | 9 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-5590-3p | hsa-mir-5590-3p | hsa-mir-5590-3p | 3 | 0.040344 | 9 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 5 | 0.000283 | 10 |
| GO:MF | GO:0008013 | beta-catenin binding | "Binding to a catenin beta subunit." [GOC:bf] | 3 | 0.000491 | 10 |
| GO:MF | GO:0017166 | vinculin binding | "Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544] | 2 | 0.000812 | 10 |
| GO:MF | GO:0045295 | gamma-catenin binding | "Binding to catenin complex gamma subunit." [GOC:bf] | 2 | 0.000812 | 10 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 4 | 0.001439 | 10 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 3 | 0.014568 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0016600 | flotillin complex | "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709] | 2 | 0.000406 | 10 |
| GO:CC | GO:0005912 | adherens junction | "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] | 3 | 0.002214 | 10 |
| GO:CC | GO:0016342 | catenin complex | "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] | 2 | 0.005228 | 10 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 5 | 0.012774 | 10 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 5 | 0.016288 | 10 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 5 | 0.017397 | 10 |
| GO:CC | GO:0005901 | caveola | "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm." [GOC:mah, ISBN:0721662544, PMID:16645198] | 2 | 0.038024 | 10 |
| GO:CC | GO:0016328 | lateral plasma membrane | "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] | 2 | 0.042747 | 10 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 3 | 0.046585 | 10 |
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 3 | 0.048707 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4753-3p | hsa-mir-4753-3p | hsa-mir-4753-3p | 6 | 0.000519 | 10 |
| MIRNA | MIRNA:hsa-mir-3613-3p | hsa-mir-3613-3p | hsa-mir-3613-3p | 6 | 0.011803 | 10 |
| MIRNA | MIRNA:hsa-mir-4765 | hsa-mir-4765 | hsa-mir-4765 | 4 | 0.012823 | 10 |
| MIRNA | MIRNA:hsa-mir-3137 | hsa-mir-3137 | hsa-mir-3137 | 4 | 0.016853 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0071681 | cellular response to indole-3-methanol | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf] | 2 | 0.000606 | 10 |
| GO:BP | GO:0071680 | response to indole-3-methanol | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf] | 2 | 0.000908 | 10 |
| GO:BP | GO:0031175 | neuron projection development | "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] | 5 | 0.001389 | 10 |
| GO:BP | GO:0048666 | neuron development | "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] | 5 | 0.002785 | 10 |
| GO:BP | GO:0007043 | cell-cell junction assembly | "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] | 3 | 0.007038 | 10 |
| GO:BP | GO:0030182 | neuron differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] | 5 | 0.007853 | 10 |
| GO:BP | GO:0048699 | generation of neurons | "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] | 5 | 0.010406 | 10 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] | 5 | 0.012267 | 10 |
| GO:BP | GO:0030030 | cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917] | 5 | 0.013997 | 10 |
| GO:BP | GO:0045216 | cell-cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 3 | 0.018406 | 10 |
| GO:BP | GO:0022008 | neurogenesis | "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] | 5 | 0.021012 | 10 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] | 3 | 0.023708 | 10 |
| GO:BP | GO:0045880 | positive regulation of smoothened signaling pathway | "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators] | 2 | 0.042402 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 3 | 0.001318 | 10 |
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 2 | 0.014672 | 10 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | Bacterial invasion of epithelial cells | 2 | 0.025894 | 10 |
| KEGG | KEGG:04520 | Adherens junction | Adherens junction | 2 | 0.037762 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 4 | 0.015386 | 10 |
| REAC | REAC:R-HSA-5626467 | RHO GTPases activate IQGAPs | RHO GTPases activate IQGAPs | 2 | 0.016168 | 10 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 4 | 0.016730 | 10 |
| REAC | REAC:R-HSA-9696273 | RND1 GTPase cycle | RND1 GTPase cycle | 2 | 0.028014 | 10 |
| REAC | REAC:R-HSA-9696270 | RND2 GTPase cycle | RND2 GTPase cycle | 2 | 0.029376 | 10 |
| REAC | REAC:R-HSA-418990 | Adherens junctions interactions | Adherens junctions interactions | 2 | 0.048203 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4534 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms | 2 | 0.043957 | 10 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030877 | beta-catenin destruction complex | "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] | 4 | 2.723452e-10 | 11 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 5 | 4.336234e-04 | 11 |
| GO:CC | GO:0005881 | cytoplasmic microtubule | "Any microtubule in the cytoplasm of a cell." [GOC:mah] | 3 | 8.857049e-04 | 11 |
| GO:CC | GO:1990909 | Wnt signalosome | "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320] | 2 | 1.051591e-03 | 11 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 5 | 3.374874e-03 | 11 |
| GO:CC | GO:0016342 | catenin complex | "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] | 2 | 6.252133e-03 | 11 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 5 | 9.594911e-03 | 11 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 5 | 4.723048e-02 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 6 | 1.790381e-09 | 11 |
| KEGG | KEGG:04310 | Wnt signaling pathway | Wnt signaling pathway | 6 | 3.349573e-09 | 11 |
| KEGG | KEGG:05217 | Basal cell carcinoma | Basal cell carcinoma | 5 | 5.618397e-09 | 11 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | Signaling pathways regulating pluripotency of stem cells | 5 | 3.682014e-07 | 11 |
| KEGG | KEGG:05224 | Breast cancer | Breast cancer | 5 | 4.233141e-07 | 11 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 5 | 4.380717e-07 | 11 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 5 | 5.181503e-07 | 11 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 5 | 7.820622e-07 | 11 |
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 4 | 1.431473e-06 | 11 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 4 | 7.126819e-06 | 11 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 5 | 2.461956e-05 | 11 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 5 | 5.111347e-05 | 11 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 5 | 1.497047e-04 | 11 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 5 | 2.534812e-04 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008013 | beta-catenin binding | "Binding to a catenin beta subunit." [GOC:bf] | 5 | 1.183795e-08 | 11 |
| GO:MF | GO:0045295 | gamma-catenin binding | "Binding to catenin complex gamma subunit." [GOC:bf] | 2 | 9.756969e-04 | 11 |
| GO:MF | GO:0070411 | I-SMAD binding | "Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 2 | 1.772826e-03 | 11 |
| GO:MF | GO:0051010 | microtubule plus-end binding | "Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] | 2 | 3.099891e-03 | 11 |
| GO:MF | GO:0070840 | dynein complex binding | "Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah] | 2 | 4.425499e-03 | 11 |
| GO:MF | GO:0008017 | microtubule binding | "Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc] | 3 | 1.283836e-02 | 11 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 3 | 1.653152e-02 | 11 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 3 | 1.958177e-02 | 11 |
| GO:MF | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity | "The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274] | 2 | 3.142926e-02 | 11 |
| GO:MF | GO:0015631 | tubulin binding | "Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] | 3 | 3.438371e-02 | 11 |
| GO:MF | GO:0046332 | SMAD binding | "Binding to a SMAD signaling protein." [GOC:ai] | 2 | 4.504719e-02 | 11 |
| GO:MF | GO:0140767 | enzyme-substrate adaptor activity | "An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity." [PMID:16250895, PMID:34358446] | 2 | 4.504719e-02 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4258 | lncRNA in canonical Wnt signaling and colorectal cancer | lncRNA in canonical Wnt signaling and colorectal cancer | 5 | 9.854252e-08 | 11 |
| WP | WP:WP4262 | Breast cancer pathway | Breast cancer pathway | 5 | 1.027979e-06 | 11 |
| WP | WP:WP4155 | Endometrial cancer | Endometrial cancer | 4 | 3.975876e-06 | 11 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 4 | 7.251577e-06 | 11 |
| WP | WP:WP5529 | Wnt Beta catenin signaling and ARTD family members | Wnt Beta catenin signaling and ARTD family members | 3 | 8.925596e-06 | 11 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 5 | 1.433687e-05 | 11 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 5 | 1.577335e-05 | 11 |
| WP | WP:WP399 | Wnt signaling and pluripotency | Wnt signaling and pluripotency | 4 | 2.599521e-05 | 11 |
| WP | WP:WP363 | Wnt signaling NetPath | Wnt signaling NetPath | 3 | 3.154721e-04 | 11 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 5 | 3.941887e-04 | 11 |
| WP | WP:WP4336 | ncRNAs in Wnt signaling in hepatocellular carcinoma | ncRNAs in Wnt signaling in hepatocellular carcinoma | 3 | 2.112474e-03 | 11 |
| WP | WP:WP2064 | Neural crest differentiation | Neural crest differentiation | 3 | 3.197317e-03 | 11 |
| WP | WP:WP710 | DNA damage response only ATM dependent | DNA damage response only ATM dependent | 3 | 4.019414e-03 | 11 |
| WP | WP:WP428 | Wnt signaling | Wnt signaling | 3 | 4.478141e-03 | 11 |
| WP | WP:WP3931 | Embryonic stem cell pluripotency pathways | Embryonic stem cell pluripotency pathways | 3 | 4.970149e-03 | 11 |
| WP | WP:WP3664 | Regulation of Wnt B catenin signaling by small molecule compounds | Regulation of Wnt B catenin signaling by small molecule compounds | 2 | 5.827301e-03 | 11 |
| WP | WP:WP3658 | Wnt beta catenin signaling in leukemia | Wnt beta catenin signaling in leukemia | 2 | 1.388735e-02 | 11 |
| WP | WP:WP2870 | Extracellular vesicle mediated signaling in recipient cells | Extracellular vesicle mediated signaling in recipient cells | 2 | 1.733263e-02 | 11 |
| WP | WP:WP4844 | Influence of laminopathies on Wnt signaling | Influence of laminopathies on Wnt signaling | 2 | 2.836300e-02 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0016055 | Wnt signaling pathway | "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397] | 6 | 7.107233e-07 | 11 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488] | 5 | 1.405442e-05 | 11 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 5 | 5.873815e-05 | 11 |
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb] | 4 | 6.123192e-05 | 11 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 1.484810e-04 | 11 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 5 | 2.269350e-04 | 11 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 5 | 4.675142e-04 | 11 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 5 | 5.056570e-04 | 11 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 5 | 5.256349e-04 | 11 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] | 4 | 7.187205e-04 | 11 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 5 | 1.422047e-03 | 11 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] | 4 | 2.033621e-03 | 11 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 5 | 5.402519e-03 | 11 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 5 | 5.638997e-03 | 11 |
| GO:BP | GO:0009950 | dorsal/ventral axis specification | "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] | 2 | 7.397648e-03 | 11 |
| GO:BP | GO:0007389 | pattern specification process | "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] | 4 | 8.671898e-03 | 11 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 5 | 1.868088e-02 | 11 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 5 | 2.584833e-02 | 11 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 5 | 2.749323e-02 | 11 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 5 | 2.758697e-02 | 11 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 5 | 3.260649e-02 | 11 |
| GO:BP | GO:0045732 | positive regulation of protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] | 3 | 3.290296e-02 | 11 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 4 | 3.312508e-02 | 11 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 6 | 3.582721e-02 | 11 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] | 3 | 3.731331e-02 | 11 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 5 | 3.747645e-02 | 11 |
| GO:BP | GO:0007026 | negative regulation of microtubule depolymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194] | 2 | 3.840811e-02 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3 | 0.000040 | 11 |
| REAC | REAC:R-HSA-201681 | TCF dependent signaling in response to WNT | TCF dependent signaling in response to WNT | 4 | 0.000185 | 11 |
| REAC | REAC:R-HSA-195721 | Signaling by WNT | Signaling by WNT | 4 | 0.000742 | 11 |
| REAC | REAC:R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | AXIN missense mutants destabilize the destruction complex | 2 | 0.002976 | 11 |
| REAC | REAC:R-HSA-4839748 | Signaling by AMER1 mutants | Signaling by AMER1 mutants | 2 | 0.002976 | 11 |
| REAC | REAC:R-HSA-4839744 | Signaling by APC mutants | Signaling by APC mutants | 2 | 0.002976 | 11 |
| REAC | REAC:R-HSA-4839735 | Signaling by AXIN mutants | Signaling by AXIN mutants | 2 | 0.002976 | 11 |
| REAC | REAC:R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | APC truncation mutants have impaired AXIN binding | 2 | 0.002976 | 11 |
| REAC | REAC:R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | Truncations of AMER1 destabilize the destruction complex | 2 | 0.002976 | 11 |
| REAC | REAC:R-HSA-5339716 | Signaling by GSK3beta mutants | Signaling by GSK3beta mutants | 2 | 0.003433 | 11 |
| REAC | REAC:R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | CTNNB1 T41 mutants aren't phosphorylated | 2 | 0.003433 | 11 |
| REAC | REAC:R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | CTNNB1 S45 mutants aren't phosphorylated | 2 | 0.003433 | 11 |
| REAC | REAC:R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | CTNNB1 S37 mutants aren't phosphorylated | 2 | 0.003433 | 11 |
| REAC | REAC:R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | CTNNB1 S33 mutants aren't phosphorylated | 2 | 0.003433 | 11 |
| REAC | REAC:R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | Signaling by CTNNB1 phospho-site mutants | 2 | 0.003433 | 11 |
| REAC | REAC:R-HSA-196299 | Beta-catenin phosphorylation cascade | Beta-catenin phosphorylation cascade | 2 | 0.004445 | 11 |
| REAC | REAC:R-HSA-4791275 | Signaling by WNT in cancer | Signaling by WNT in cancer | 2 | 0.018280 | 11 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 3 | 0.037468 | 11 |
| REAC | REAC:R-HSA-4641257 | Degradation of AXIN | Degradation of AXIN | 2 | 0.048203 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0033769 | Fundic gland polyposis | Multiple polyps in the acid-secreting mucosa of the gastric body and fundus. Fundic gland polyps (FGP) are usually 1 to 5 mm in size, though larger polyps have been found. FGPs are typically sessile, shiny, translucent, pale to pinkish in color (resembling the surrounding mucosa), and often exhibit tiny surface blood vessels. These polyps have characteristically been observed to chunk off or detach entirely at the base when removed with cold forceps, in contrast to other types of gastric polyps. | 2 | 0.001769 | 11 |
| HP | HP:0011069 | Supernumerary tooth | The presence of one or more teeth additional to the normal number. | 3 | 0.037400 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4528 | hsa-mir-4528 | hsa-mir-4528 | 5 | 0.008288 | 11 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:824 | Anti-SMN protein complex | Anti-SMN protein complex | 2 | 0.000089 | 12 |
| CORUM | CORUM:3296 | SMN complex (GEMIN5,4,3), SMN-independent intermediate | SMN complex (GEMIN5,4,3), SMN-independent intermediate | 2 | 0.000089 | 12 |
| CORUM | CORUM:1750 | PPP4C-PPP4R2-Gemin3-Gemin4 complex | PPP4C-PPP4R2-Gemin3-Gemin4 complex | 2 | 0.000177 | 12 |
| CORUM | CORUM:3284 | SMN complex (GEMIN2, GEMIN3, GEMIN4, GEMIN5, SMN) | SMN complex (GEMIN2, GEMIN3, GEMIN4, GEMIN5, SMN) | 2 | 0.000177 | 12 |
| CORUM | CORUM:832 | Anti-Sm protein complex | Anti-Sm protein complex | 2 | 0.000295 | 12 |
| CORUM | CORUM:1752 | SMN complex | SMN complex | 2 | 0.000443 | 12 |
| CORUM | CORUM:1749 | SMN-PolII-RHA complex | SMN-PolII-RHA complex | 2 | 0.000827 | 12 |
| CORUM | CORUM:1751 | SMN complex | SMN complex | 2 | 0.000827 | 12 |
| CORUM | CORUM:1143 | SMN complex | SMN complex | 2 | 0.002684 | 12 |
| CORUM | CORUM:1745 | SMN complex | SMN complex | 2 | 0.002684 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0032797 | SMN complex | "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415] | 2 | 0.000186 | 12 |
| GO:CC | GO:0097504 | Gemini of Cajal bodies | "Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA)." [GOC:pr, PMID:11031238, PMID:9683623, Wikipedia:Cell_nucleus#Cajal_bodies_and_gems] | 2 | 0.000223 | 12 |
| GO:CC | GO:0034719 | SMN-Sm protein complex | "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408] | 2 | 0.000516 | 12 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 3 | 0.035121 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-194441 | Metabolism of non-coding RNA | Metabolism of non-coding RNA | 2 | 0.011538 | 12 |
| REAC | REAC:R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | SARS-CoV-2 modulates host translation machinery | 2 | 0.011538 | 12 |
| REAC | REAC:R-HSA-191859 | snRNP Assembly | snRNP Assembly | 2 | 0.011538 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0030851 | granulocyte differentiation | "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm] | 2 | 0.014803 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP411 | mRNA processing | mRNA processing | 2 | 0.039889 | 12 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005788 | endoplasmic reticulum lumen | "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] | 6 | 8.285456e-09 | 13 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 5 | 1.086182e-08 | 13 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 5 | 1.086182e-08 | 13 |
| GO:CC | GO:0140534 | endoplasmic reticulum protein-containing complex | "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] | 5 | 1.186525e-08 | 13 |
| GO:CC | GO:1902687 | glucosidase complex | "A protein complex which is capable of glucosidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932] | 2 | 1.350428e-05 | 13 |
| GO:CC | GO:0017177 | glucosidase II complex | "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335] | 2 | 1.350428e-05 | 13 |
| GO:CC | GO:0005783 | endoplasmic reticulum | "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] | 6 | 7.220211e-04 | 13 |
| GO:CC | GO:0034663 | endoplasmic reticulum chaperone complex | "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] | 2 | 7.417298e-04 | 13 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 6 | 2.338072e-03 | 13 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 6 | 2.370618e-03 | 13 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 7 | 3.916714e-03 | 13 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 6 | 1.077916e-02 | 13 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 4 | 1.426940e-02 | 13 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 5 | 2.199420e-02 | 13 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 5 | 2.354596e-02 | 13 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 5 | 2.359912e-02 | 13 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 5 | 2.359912e-02 | 13 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 6 | 3.386369e-02 | 13 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 7 | 3.628566e-02 | 13 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 7 | 3.628566e-02 | 13 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 7 | 3.628566e-02 | 13 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 3 | 3.682217e-02 | 13 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 3 | 3.942895e-02 | 13 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 6 | 4.642799e-02 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 6 | 1.844472e-08 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003756 | protein disulfide isomerase activity | "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function] | 3 | 0.000004 | 13 |
| GO:MF | GO:0016864 | intramolecular oxidoreductase activity, transposing S-S bonds | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4.-, GOC:mah] | 3 | 0.000004 | 13 |
| GO:MF | GO:0015035 | protein-disulfide reductase activity | "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385] | 3 | 0.000022 | 13 |
| GO:MF | GO:0015036 | disulfide oxidoreductase activity | "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [GOC:curators] | 3 | 0.000036 | 13 |
| GO:MF | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.8.-.-, GOC:ai] | 3 | 0.000095 | 13 |
| GO:MF | GO:0016860 | intramolecular oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators] | 3 | 0.000101 | 13 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 6 | 0.011091 | 13 |
| GO:MF | GO:0033919 | glucan 1,3-alpha-glucosidase activity | "Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans." [EC:3.2.1.84] | 1 | 0.049963 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0034975 | protein folding in endoplasmic reticulum | "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw] | 3 | 0.000005 | 13 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 4 | 0.000391 | 13 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 4 | 0.000903 | 13 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 4 | 0.014057 | 13 |
| GO:BP | GO:0006491 | N-glycan processing | "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198] | 2 | 0.016202 | 13 |
| GO:BP | GO:0098761 | cellular response to interleukin-7 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] | 2 | 0.018000 | 13 |
| GO:BP | GO:0098760 | response to interleukin-7 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] | 2 | 0.019891 | 13 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 7 | 0.028671 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-901042 | Calnexin/calreticulin cycle | Calnexin/calreticulin cycle | 3 | 0.000053 | 13 |
| REAC | REAC:R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3 | 0.000132 | 13 |
| REAC | REAC:R-HSA-9683686 | Maturation of spike protein | Maturation of spike protein | 2 | 0.000558 | 13 |
| REAC | REAC:R-HSA-8957275 | Post-translational protein phosphorylation | Post-translational protein phosphorylation | 3 | 0.003942 | 13 |
| REAC | REAC:R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 3 | 0.006138 | 13 |
| REAC | REAC:R-HSA-9683701 | Translation of Structural Proteins | Translation of Structural Proteins | 2 | 0.022509 | 13 |
| REAC | REAC:R-HSA-9694548 | Maturation of spike protein | Maturation of spike protein | 2 | 0.036852 | 13 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 5 | 0.047682 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00687 | Factor: alpha-CP1; motif: CAGCCAATGAG | Factor: alpha-CP1; motif: CAGCCAATGAG | 7 | 0.000390 | 13 |
| TF | TF:M12616 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS | 7 | 0.001560 | 13 |
| TF | TF:M04683 | Factor: NF-YA; motif: YTCTSATTGGYYRN | Factor: NF-YA; motif: YTCTSATTGGYYRN | 6 | 0.003049 | 13 |
| TF | TF:M03805_1 | Factor: YB-1; motif: CCAMTCNGMR; match class: 1 | Factor: YB-1; motif: CCAMTCNGMR; match class: 1 | 7 | 0.009444 | 13 |
| TF | TF:M12616_1 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS; match class: 1 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS; match class: 1 | 4 | 0.023049 | 13 |
| TF | TF:M10006 | Factor: NF-YC; motif: NNRRCCAATCAGNR | Factor: NF-YC; motif: NNRRCCAATCAGNR | 6 | 0.032540 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 6 | 0.004303 | 13 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 6 | 0.012615 | 13 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 6 | 0.016765 | 13 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 5 | 0.029138 | 13 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 4 | 0.032308 | 13 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 4 | 0.032901 | 13 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 4 | 0.035352 | 13 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 4 | 0.037495 | 13 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 4 | 0.046251 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3995 | Prion disease pathway | Prion disease pathway | 2 | 0.013164 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0006557 | Polycystic liver disease | Polycystic liver disease | 2 | 0.022 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:472 | Prolyl 4-hydroxylase (alpha(I)-type) | Prolyl 4-hydroxylase (alpha(I)-type) | 1 | 0.049932 | 13 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 7 | 0.000004 | 14 |
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 4 | 0.001497 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045333 | cellular respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] | 3 | 0.026212 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-71403 | Citric acid cycle (TCA cycle) | Citric acid cycle (TCA cycle) | 2 | 0.027479 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M10673_1 | Factor: Emx-2; motif: YTAATTAN; match class: 1 | Factor: Emx-2; motif: YTAATTAN; match class: 1 | 4 | 0.04657 | 14 |
| TF | TF:M04446_1 | Factor: VAX1; motif: YTAATTAN; match class: 1 | Factor: VAX1; motif: YTAATTAN; match class: 1 | 4 | 0.04657 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0046554 | L-malate dehydrogenase (NADP+) activity | "Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+." [RHEA:10824] | 1 | 0.049963 | 14 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP51 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 4 | 0.000038 | 15 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 4 | 0.002657 | 15 |
| WP | WP:WP437 | EGF EGFR signaling | EGF EGFR signaling | 3 | 0.005406 | 15 |
| WP | WP:WP306 | Focal adhesion | Focal adhesion | 3 | 0.010606 | 15 |
| WP | WP:WP5493 | Effect of dasatinib on the BCR ABL signaling pathway | Effect of dasatinib on the BCR ABL signaling pathway | 2 | 0.024615 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2470 | p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex | p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex | 2 | 0.000132 | 15 |
| CORUM | CORUM:5177 | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | 2 | 0.000924 | 15 |
| CORUM | CORUM:2480 | CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) | CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) | 2 | 0.000924 | 15 |
| CORUM | CORUM:2574 | CD19-VAV1-PIK3R1 complex | CD19-VAV1-PIK3R1 complex | 1 | 0.049680 | 15 |
| CORUM | CORUM:7361 | ARAF-PIK3R1 complex | ARAF-PIK3R1 complex | 1 | 0.049680 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 4 | 0.000352 | 15 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 4 | 0.000485 | 15 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | Bacterial invasion of epithelial cells | 3 | 0.000691 | 15 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | Leukocyte transendothelial migration | 3 | 0.002250 | 15 |
| KEGG | KEGG:04510 | Focal adhesion | Focal adhesion | 3 | 0.012366 | 15 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | Rap1 signaling pathway | 3 | 0.013872 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-76002 | Platelet activation, signaling and aggregation | Platelet activation, signaling and aggregation | 4 | 0.000976 | 15 |
| REAC | REAC:R-HSA-186763 | Downstream signal transduction | Downstream signal transduction | 2 | 0.018032 | 15 |
| REAC | REAC:R-HSA-912526 | Interleukin receptor SHC signaling | Interleukin receptor SHC signaling | 2 | 0.020962 | 15 |
| REAC | REAC:R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | Signaling by CSF1 (M-CSF) in myeloid cells | 2 | 0.024111 | 15 |
| REAC | REAC:R-HSA-109582 | Hemostasis | Hemostasis | 4 | 0.042922 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 4 | 0.002950 | 15 |
| GO:BP | GO:0120031 | plasma membrane bounded cell projection assembly | "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 4 | 0.008401 | 15 |
| GO:BP | GO:0030031 | cell projection assembly | "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:18391171] | 4 | 0.009145 | 15 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 4 | 0.018156 | 15 |
| GO:BP | GO:0051497 | negative regulation of stress fiber assembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] | 2 | 0.022828 | 15 |
| GO:BP | GO:0032232 | negative regulation of actin filament bundle assembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] | 2 | 0.028071 | 15 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 4 | 0.029585 | 15 |
| GO:BP | GO:0110053 | regulation of actin filament organization | "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] | 3 | 0.033602 | 15 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 4 | 0.035008 | 15 |
| GO:BP | GO:0032868 | response to insulin | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 3 | 0.036341 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 4 | 0.007395 | 15 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 3 | 0.024970 | 15 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 3 | 0.026746 | 15 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 6 | 0.044795 | 15 |
| GO:CC | GO:0090637 | inner dense plaque of desmosome | "The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane." [PMID:20066089] | 1 | 0.049980 | 15 |
| GO:CC | GO:0061826 | podosome ring | "The ring structure surrounding the podosome core, containing proteins such as vinculin and talin." [PMID:23158496] | 1 | 0.049980 | 15 |
| GO:CC | GO:0090636 | outer dense plaque of desmosome | "The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane." [PMID:20066089] | 1 | 0.049980 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0001784 | phosphotyrosine residue binding | "Binding to a phosphorylated tyrosine residue within a protein." [PMID:14636584] | 2 | 0.013241 | 15 |
| GO:MF | GO:0045309 | protein phosphorylated amino acid binding | "Binding to a phosphorylated amino acid residue within a protein." [GOC:go_curators] | 2 | 0.020925 | 15 |
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 3 | 0.033133 | 15 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 6 | 4.149338e-10 | 16 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 6 | 3.109428e-08 | 16 |
| GO:CC | GO:1990647 | C/EBP complex | "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121] | 2 | 1.128323e-05 | 16 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 6 | 1.185023e-05 | 16 |
| GO:CC | GO:0036488 | CHOP-C/EBP complex | "A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors." [GOC:bf, GOC:PARL, PMID:1547942] | 2 | 3.384561e-05 | 16 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 6 | 9.963091e-05 | 16 |
| GO:CC | GO:0071144 | heteromeric SMAD protein complex | "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] | 2 | 3.157022e-04 | 16 |
| GO:CC | GO:0071141 | SMAD protein complex | "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020] | 2 | 4.058539e-04 | 16 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 6 | 5.735870e-04 | 16 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 6 | 9.247745e-03 | 16 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 6 | 4.508711e-02 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] | 6 | 2.863259e-08 | 16 |
| GO:MF | GO:0001216 | DNA-binding transcription activator activity | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] | 6 | 3.125090e-08 | 16 |
| GO:MF | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018] | 6 | 6.620536e-06 | 16 |
| GO:MF | GO:0000987 | cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018] | 6 | 7.433167e-06 | 16 |
| GO:MF | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] | 6 | 1.530865e-05 | 16 |
| GO:MF | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] | 6 | 1.722883e-05 | 16 |
| GO:MF | GO:0003700 | DNA-binding transcription factor activity | "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] | 6 | 2.231550e-05 | 16 |
| GO:MF | GO:0000976 | transcription cis-regulatory region binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] | 6 | 2.596967e-05 | 16 |
| GO:MF | GO:0001067 | transcription regulatory region nucleic acid binding | "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] | 6 | 2.607495e-05 | 16 |
| GO:MF | GO:1990837 | sequence-specific double-stranded DNA binding | "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] | 6 | 3.320671e-05 | 16 |
| GO:MF | GO:0003690 | double-stranded DNA binding | "Binding to double-stranded DNA." [GOC:elh, GOC:vw] | 6 | 4.785682e-05 | 16 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 6 | 5.017636e-05 | 16 |
| GO:MF | GO:0042803 | protein homodimerization activity | "Binding to an identical protein to form a homodimer." [GOC:jl] | 5 | 5.933867e-05 | 16 |
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 6 | 1.351171e-04 | 16 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 6 | 2.622047e-04 | 16 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 5 | 5.083843e-04 | 16 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 6 | 6.561281e-04 | 16 |
| GO:MF | GO:0031490 | chromatin DNA binding | "Binding to DNA that is assembled into chromatin." [GOC:mah] | 3 | 1.320433e-03 | 16 |
| GO:MF | GO:0070411 | I-SMAD binding | "Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 2 | 1.475904e-03 | 16 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 4 | 2.316546e-03 | 16 |
| GO:MF | GO:0070412 | R-SMAD binding | "Binding to a receptor-regulated SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 2 | 3.991974e-03 | 16 |
| GO:MF | GO:0001217 | DNA-binding transcription repressor activity | "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets." [GOC:txnOH-2018] | 3 | 8.544088e-03 | 16 |
| GO:MF | GO:0001223 | transcription coactivator binding | "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] | 2 | 1.324121e-02 | 16 |
| GO:MF | GO:0001222 | transcription corepressor binding | "Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc] | 2 | 1.440107e-02 | 16 |
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 3 | 1.631278e-02 | 16 |
| GO:MF | GO:0005518 | collagen binding | "Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732] | 2 | 2.949184e-02 | 16 |
| GO:MF | GO:0046332 | SMAD binding | "Binding to a SMAD signaling protein." [GOC:ai] | 2 | 3.758034e-02 | 16 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 3 | 4.438935e-02 | 16 |
| GO:MF | GO:0031962 | nuclear mineralocorticoid receptor binding | "Binding to a nuclear mineralocorticoid receptor." [GOC:mah, PMID:12511169] | 1 | 4.989139e-02 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0001649 | osteoblast differentiation | "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid] | 5 | 8.685512e-07 | 16 |
| GO:BP | GO:0001503 | ossification | "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] | 5 | 1.841552e-05 | 16 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] | 4 | 1.908873e-05 | 16 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 6 | 4.011395e-05 | 16 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 6 | 4.494848e-05 | 16 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 6 | 4.843376e-05 | 16 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 6 | 7.703016e-05 | 16 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 6 | 1.308372e-04 | 16 |
| GO:BP | GO:0140467 | integrated stress response signaling | "The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041] | 3 | 1.984302e-04 | 16 |
| GO:BP | GO:0045444 | fat cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators] | 4 | 2.214652e-04 | 16 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 6 | 2.447936e-04 | 16 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 6 | 2.465322e-04 | 16 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 6 | 3.915747e-04 | 16 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 6 | 5.012666e-04 | 16 |
| GO:BP | GO:0045669 | positive regulation of osteoblast differentiation | "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] | 3 | 6.265308e-04 | 16 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 5 | 6.531868e-04 | 16 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 6 | 7.311660e-04 | 16 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 5 | 9.023302e-04 | 16 |
| GO:BP | GO:0032906 | transforming growth factor beta2 production | "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] | 2 | 1.695267e-03 | 16 |
| GO:BP | GO:0032909 | regulation of transforming growth factor beta2 production | "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] | 2 | 1.695267e-03 | 16 |
| GO:BP | GO:0001701 | in utero embryonic development | "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] | 4 | 1.904681e-03 | 16 |
| GO:BP | GO:0048732 | gland development | "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] | 4 | 2.776140e-03 | 16 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 6 | 3.018010e-03 | 16 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 6 | 3.125021e-03 | 16 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 5 | 3.220978e-03 | 16 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 6 | 3.948692e-03 | 16 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 6 | 4.082483e-03 | 16 |
| GO:BP | GO:0045598 | regulation of fat cell differentiation | "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] | 3 | 4.357586e-03 | 16 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 6 | 4.399782e-03 | 16 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 6 | 5.096276e-03 | 16 |
| GO:BP | GO:0051094 | positive regulation of developmental process | "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 5 | 5.355867e-03 | 16 |
| GO:BP | GO:1901203 | positive regulation of extracellular matrix assembly | "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] | 2 | 5.505425e-03 | 16 |
| GO:BP | GO:0001889 | liver development | "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] | 3 | 5.887538e-03 | 16 |
| GO:BP | GO:0061008 | hepaticobiliary system development | "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] | 3 | 6.255971e-03 | 16 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 6 | 6.990393e-03 | 16 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 4 | 8.738403e-03 | 16 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 6 | 8.870947e-03 | 16 |
| GO:BP | GO:0070102 | interleukin-6-mediated signaling pathway | "The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling] | 2 | 9.251677e-03 | 16 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 6 | 1.018907e-02 | 16 |
| GO:BP | GO:1901201 | regulation of extracellular matrix assembly | "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] | 2 | 1.148609e-02 | 16 |
| GO:BP | GO:0045595 | regulation of cell differentiation | "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] | 5 | 1.181552e-02 | 16 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 6 | 1.300650e-02 | 16 |
| GO:BP | GO:0043009 | chordate embryonic development | "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] | 4 | 1.308128e-02 | 16 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] | 4 | 1.477716e-02 | 16 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 6 | 1.521470e-02 | 16 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] | 4 | 1.599505e-02 | 16 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 6 | 1.615853e-02 | 16 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 5 | 1.643781e-02 | 16 |
| GO:BP | GO:0014898 | cardiac muscle hypertrophy in response to stress | "The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] | 2 | 1.667660e-02 | 16 |
| GO:BP | GO:0003299 | muscle hypertrophy in response to stress | "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart] | 2 | 1.667660e-02 | 16 |
| GO:BP | GO:0014887 | cardiac muscle adaptation | "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle] | 2 | 1.667660e-02 | 16 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 6 | 1.670688e-02 | 16 |
| GO:BP | GO:0030855 | epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] | 4 | 1.988670e-02 | 16 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 6 | 2.057555e-02 | 16 |
| GO:BP | GO:0030325 | adrenal gland development | "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh] | 2 | 2.120021e-02 | 16 |
| GO:BP | GO:0010614 | negative regulation of cardiac muscle hypertrophy | "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] | 2 | 2.120021e-02 | 16 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 6 | 2.230399e-02 | 16 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] | 3 | 2.251715e-02 | 16 |
| GO:BP | GO:0014741 | negative regulation of muscle hypertrophy | "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle] | 2 | 2.451595e-02 | 16 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 6 | 2.587158e-02 | 16 |
| GO:BP | GO:1903055 | positive regulation of extracellular matrix organization | "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] | 2 | 2.626376e-02 | 16 |
| GO:BP | GO:0071634 | regulation of transforming growth factor beta production | "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah] | 2 | 2.807149e-02 | 16 |
| GO:BP | GO:0071354 | cellular response to interleukin-6 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 2 | 2.993912e-02 | 16 |
| GO:BP | GO:0042593 | glucose homeostasis | "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] | 3 | 3.322246e-02 | 16 |
| GO:BP | GO:0033500 | carbohydrate homeostasis | "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] | 3 | 3.360217e-02 | 16 |
| GO:BP | GO:0071604 | transforming growth factor beta production | "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3." [GOC:add, GOC:rv, PMID:16891311, PMID:2022183] | 2 | 3.385400e-02 | 16 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 6 | 3.900892e-02 | 16 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 5 | 3.967461e-02 | 16 |
| GO:BP | GO:0070741 | response to interleukin-6 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 2 | 4.017501e-02 | 16 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 5 | 4.134813e-02 | 16 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 6 | 4.156768e-02 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4879 | Overlap between signal transduction pathways contributing to LMNA laminopathies | Overlap between signal transduction pathways contributing to LMNA laminopathies | 4 | 0.000003 | 16 |
| WP | WP:WP4211 | Transcriptional cascade regulating adipogenesis | Transcriptional cascade regulating adipogenesis | 3 | 0.000006 | 16 |
| WP | WP:WP3599 | Transcription factor regulation in adipogenesis | Transcription factor regulation in adipogenesis | 3 | 0.000030 | 16 |
| WP | WP:WP236 | Adipogenesis | Adipogenesis | 4 | 0.000075 | 16 |
| WP | WP:WP4149 | White fat cell differentiation | White fat cell differentiation | 3 | 0.000097 | 16 |
| WP | WP:WP4844 | Influence of laminopathies on Wnt signaling | Influence of laminopathies on Wnt signaling | 3 | 0.000152 | 16 |
| WP | WP:WP5474 | Catabolism of skeletal muscle in cachexia | Catabolism of skeletal muscle in cachexia | 3 | 0.000193 | 16 |
| WP | WP:WP5382 | TGFB Smad signaling | TGFB Smad signaling | 2 | 0.002832 | 16 |
| WP | WP:WP615 | Senescence and autophagy in cancer | Senescence and autophagy in cancer | 3 | 0.003593 | 16 |
| WP | WP:WP3874 | Canonical and non canonical TGF B signaling | Canonical and non canonical TGF B signaling | 2 | 0.005827 | 16 |
| WP | WP:WP3859 | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | 2 | 0.007323 | 16 |
| WP | WP:WP4482 | Vitamin D in inflammatory diseases | Vitamin D in inflammatory diseases | 2 | 0.009883 | 16 |
| WP | WP:WP5103 | Progeria associated lipodystrophy | Progeria associated lipodystrophy | 2 | 0.009883 | 16 |
| WP | WP:WP2895 | Differentiation of white and brown adipocyte | Differentiation of white and brown adipocyte | 2 | 0.012823 | 16 |
| WP | WP:WP3668 | Hypothesized pathways in pathogenesis of cardiovascular disease | Hypothesized pathways in pathogenesis of cardiovascular disease | 2 | 0.012823 | 16 |
| WP | WP:WP5036 | Angiotensin II receptor type 1 pathway | Angiotensin II receptor type 1 pathway | 2 | 0.016142 | 16 |
| WP | WP:WP2870 | Extracellular vesicle mediated signaling in recipient cells | Extracellular vesicle mediated signaling in recipient cells | 2 | 0.017333 | 16 |
| WP | WP:WP2112 | IL17 signaling | IL17 signaling | 2 | 0.021155 | 16 |
| WP | WP:WP34 | Ovarian infertility | Ovarian infertility | 2 | 0.031538 | 16 |
| WP | WP:WP2817 | Mammary gland development pregnancy and lactation stage 3 of 4 | Mammary gland development pregnancy and lactation stage 3 of 4 | 2 | 0.042058 | 16 |
| WP | WP:WP4535 | Envelope proteins and their potential roles in EDMD physiopathology | Envelope proteins and their potential roles in EDMD physiopathology | 2 | 0.043957 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9843745 | Adipogenesis | Adipogenesis | 4 | 0.000029 | 16 |
| REAC | REAC:R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | SMAD4 MH2 Domain Mutants in Cancer | 2 | 0.000167 | 16 |
| REAC | REAC:R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | Loss of Function of SMAD4 in Cancer | 2 | 0.000167 | 16 |
| REAC | REAC:R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | SMAD2/3 MH2 Domain Mutants in Cancer | 2 | 0.000167 | 16 |
| REAC | REAC:R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | RUNX3 regulates BCL2L11 (BIM) transcription | 2 | 0.000558 | 16 |
| REAC | REAC:R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | Loss of Function of SMAD2/3 in Cancer | 2 | 0.000836 | 16 |
| REAC | REAC:R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | Signaling by TGF-beta Receptor Complex in Cancer | 2 | 0.001170 | 16 |
| REAC | REAC:R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | RUNX3 regulates CDKN1A transcription | 2 | 0.001170 | 16 |
| REAC | REAC:R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | Transcriptional regulation of white adipocyte differentiation | 3 | 0.001834 | 16 |
| REAC | REAC:R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | Response of EIF2AK1 (HRI) to heme deficiency | 2 | 0.005841 | 16 |
| REAC | REAC:R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2 | 0.005841 | 16 |
| REAC | REAC:R-HSA-9823730 | Formation of definitive endoderm | Formation of definitive endoderm | 2 | 0.005841 | 16 |
| REAC | REAC:R-HSA-9754189 | Germ layer formation at gastrulation | Germ layer formation at gastrulation | 2 | 0.007562 | 16 |
| REAC | REAC:R-HSA-1502540 | Signaling by Activin | Signaling by Activin | 2 | 0.007562 | 16 |
| REAC | REAC:R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | FOXO-mediated transcription of cell cycle genes | 2 | 0.007562 | 16 |
| REAC | REAC:R-HSA-1181150 | Signaling by NODAL | Signaling by NODAL | 2 | 0.014047 | 16 |
| REAC | REAC:R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | ATF4 activates genes in response to endoplasmic reticulum stress | 2 | 0.019469 | 16 |
| REAC | REAC:R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2 | 0.022509 | 16 |
| REAC | REAC:R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 2 | 0.024111 | 16 |
| REAC | REAC:R-HSA-381042 | PERK regulates gene expression | PERK regulates gene expression | 2 | 0.027479 | 16 |
| REAC | REAC:R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2 | 0.034869 | 16 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 5 | 0.037846 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3959 | SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent | SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent | 2 | 0.000059 | 16 |
| CORUM | CORUM:3740 | SKI-SMAD3-SMAD4 complex | SKI-SMAD3-SMAD4 complex | 2 | 0.000059 | 16 |
| CORUM | CORUM:2705 | SMAD3-SMAD4-CTCF protein-DNA complex | SMAD3-SMAD4-CTCF protein-DNA complex | 2 | 0.000177 | 16 |
| CORUM | CORUM:2706 | SMAD3-SMAD4-SP1 complex | SMAD3-SMAD4-SP1 complex | 2 | 0.000177 | 16 |
| CORUM | CORUM:2708 | SMAD3-SMAD4-cJUN complex | SMAD3-SMAD4-cJUN complex | 2 | 0.000177 | 16 |
| CORUM | CORUM:2760 | SMAD3-SMAD4-FOXO3 complex | SMAD3-SMAD4-FOXO3 complex | 2 | 0.000177 | 16 |
| CORUM | CORUM:2762 | SMAD3-SMAD4-FOXO4 complex | SMAD3-SMAD4-FOXO4 complex | 2 | 0.000177 | 16 |
| CORUM | CORUM:2761 | SMAD3-SMAD4-FOXO1 complex | SMAD3-SMAD4-FOXO1 complex | 2 | 0.000177 | 16 |
| CORUM | CORUM:2834 | SMAD4-SMAD2-SMAD3 complex | SMAD4-SMAD2-SMAD3 complex | 2 | 0.000177 | 16 |
| CORUM | CORUM:6649 | SMAD3-SMAD4-WWTR1 complex | SMAD3-SMAD4-WWTR1 complex | 2 | 0.000177 | 16 |
| CORUM | CORUM:3754 | CREBBP-SMAD3-SMAD4 pentameric complex | CREBBP-SMAD3-SMAD4 pentameric complex | 2 | 0.000177 | 16 |
| CORUM | CORUM:2754 | JUND-FOSB-SMAD3-SMAD4 complex | JUND-FOSB-SMAD3-SMAD4 complex | 2 | 0.000354 | 16 |
| CORUM | CORUM:2707 | SMAD3-SMAD4-FOXO3-FOXG1 complex | SMAD3-SMAD4-FOXO3-FOXG1 complex | 2 | 0.000354 | 16 |
| CORUM | CORUM:2692 | SMAD3-SMAD4-cJun-cFos complex | SMAD3-SMAD4-cJun-cFos complex | 2 | 0.000354 | 16 |
| CORUM | CORUM:1474 | SMAD3/4-E2F4/5-p107-DP1 complex | SMAD3/4-E2F4/5-p107-DP1 complex | 2 | 0.000884 | 16 |
| CORUM | CORUM:2829 | RSmad complex | RSmad complex | 2 | 0.002645 | 16 |
| CORUM | CORUM:3200 | SMAD4-SKI complex | SMAD4-SKI complex | 1 | 0.049932 | 16 |
| CORUM | CORUM:3197 | SMAD4-SNO-SKI complex | SMAD4-SNO-SKI complex | 1 | 0.049932 | 16 |
| CORUM | CORUM:3733 | SKI-SMAD3 complex | SKI-SMAD3 complex | 1 | 0.049932 | 16 |
| CORUM | CORUM:3199 | SKI-SMAD3 complex | SKI-SMAD3 complex | 1 | 0.049932 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 2 | 0.025225 | 16 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 2 | 0.025225 | 16 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 2 | 0.032299 | 16 |
| KEGG | KEGG:04520 | Adherens junction | Adherens junction | 2 | 0.037762 | 16 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | AGE-RAGE signaling pathway in diabetic complications | 2 | 0.043646 | 16 |
| KEGG | KEGG:04659 | Th17 cell differentiation | Th17 cell differentiation | 2 | 0.048105 | 16 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 3 | 0.048841 | 16 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | TGF-beta signaling pathway | 2 | 0.049948 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032079 | Medial degeneration | Medial degeneration of the aorta is to be used as an overarching term for any aortic surgical specimens that demonstrate one or more of the specific histopathologies mucoid extracellular matrix accumulation, elastic fiber fragmentation and/or loss, elastic fiber thinning, elastic fiber disorganization, smooth muscle cell nuclei loss, laminar medial collapse, smooth muscle cell disorganization, medial fibrosis. Grading of medial degeneration is based on the average overall severity of specific histopathologies as described, considering the worst area(s) sampled from multiple slides and aorta sections. | 2 | 0.028340 | 16 |
| HP | HP:0012180 | Cystic medial necrosis | A disorder of large arteries, in particular the aorta, characterized by an accumulation of basophilic ground substance in the media with cyst-like lesions associated with degenerative changes of collagen, elastin and the vascular smooth muscle cells. | 2 | 0.028340 | 16 |
| HP | HP:0004959 | Descending thoracic aorta aneurysm | An abnormal localized widening (dilatation) of the descending thoracic aorta. | 2 | 0.028340 | 16 |
| HP | HP:0200146 | Mucoid extracellular matrix accumulation | An increase of medial mucoid extracellular matrix creating translamellar and/or intralamellar expansions including extracellular pools as noted on an H&E stain and/or a stain to highlight extracellular matrix material (Movat's pentachrome, Alcian blue, etc.). | 2 | 0.028340 | 16 |
| HP | HP:0012763 | Paroxysmal dyspnea | A sudden attack of dyspnea that occurs while the affected person is at rest. | 2 | 0.031485 | 16 |
| HP | HP:0012499 | Descending aortic dissection | A separation of the layers within the wall of the descending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space. | 2 | 0.034795 | 16 |
| HP | HP:0012163 | Carotid artery dilatation | A dilatation (balooning or bulging out of the vessel wall) of a carotid artery. | 2 | 0.041909 | 16 |
| HP | HP:0005112 | Abdominal aortic aneurysm | An abnormal localized widening (dilatation) of the abdominal aorta. | 2 | 0.045712 | 16 |
| HP | HP:0100775 | Dural ectasia | A widening or ballooning of the dural sac surrounding the spinal cord usually at the lumbosacral level. | 2 | 0.045712 | 16 |
| HP | HP:0010303 | Abnormal spinal meningeal morphology | Any abnormality of the spinal meninges, the system of membranes (dura mater, the arachnoid mater, and the pia mater) which envelops the spinal cord. | 2 | 0.049681 | 16 |
| HP | HP:0012432 | Chronic fatigue | Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer. | 2 | 0.049681 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-182-3p | hsa-mir-182-3p | hsa-mir-182-3p | 2 | 0.033264 | 16 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0035101 | FACT complex | "A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage." [PMID:12934006, PMID:12934007, PMID:16678108, PMID:34731638] | 2 | 0.000014 | 17 |
| GO:CC | GO:0042555 | MCM complex | "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] | 2 | 0.000124 | 17 |
| GO:CC | GO:0008023 | transcription elongation factor complex | "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] | 2 | 0.002873 | 17 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 3 | 0.001206 | 17 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 3 | 0.012821 | 17 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 3 | 0.040141 | 17 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2791 | MCM4-MCM6-MCM7 complex | MCM4-MCM6-MCM7 complex | 1 | 0.049932 | 17 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005783 | endoplasmic reticulum | "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] | 6 | 0.000131 | 18 |
| GO:CC | GO:0005789 | endoplasmic reticulum membrane | "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] | 5 | 0.000560 | 18 |
| GO:CC | GO:0098827 | endoplasmic reticulum subcompartment | "A distinct region of the endoplasmic reticulum." [GOC:dos] | 5 | 0.000574 | 18 |
| GO:CC | GO:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network | "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] | 5 | 0.000619 | 18 |
| GO:CC | GO:0031984 | organelle subcompartment | "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] | 5 | 0.001807 | 18 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 6 | 0.020849 | 18 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00302_1 | Factor: NFAT; motif: NANWGGAAAANN; match class: 1 | Factor: NFAT; motif: NANWGGAAAANN; match class: 1 | 2 | 0.019947 | 18 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-662 | hsa-mir-662 | hsa-mir-662 | 3 | 0.027338 | 18 |
| MIRNA | MIRNA:hsa-mir-595 | hsa-mir-595 | hsa-mir-595 | 4 | 0.029201 | 18 |
| MIRNA | MIRNA:hsa-mir-548ac | hsa-mir-548ac | hsa-mir-548ac | 5 | 0.040455 | 18 |
| MIRNA | MIRNA:hsa-mir-548z | hsa-mir-548z | hsa-mir-548z | 5 | 0.040455 | 18 |
| MIRNA | MIRNA:hsa-mir-548d-3p | hsa-mir-548d-3p | hsa-mir-548d-3p | 5 | 0.040988 | 18 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7477 | TANGO1L-cTAGE5-SEC12 complex | TANGO1L-cTAGE5-SEC12 complex | 1 | 0.049932 | 18 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5285 | TNF-alpha/NF-kappa B signaling complex 9 | TNF-alpha/NF-kappa B signaling complex 9 | 2 | 0.000148 | 19 |
| CORUM | CORUM:5269 | TNF-alpha/NF-kappa B signaling complex 8 | TNF-alpha/NF-kappa B signaling complex 8 | 2 | 0.000221 | 19 |
| CORUM | CORUM:5268 | TNF-alpha/NF-kappa B signaling complex 7 | TNF-alpha/NF-kappa B signaling complex 7 | 2 | 0.000413 | 19 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990565 | HSP90-CDC37 chaperone complex | "A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." [GOC:bhm, GOC:pad, GOC:PARL, PMID:21855797, PMID:22939624] | 1 | 0.049885 | 19 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016231 | beta-N-acetylglucosaminidase activity | "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [PMID:29143882, PMID:37590576] | 1 | 0.049891 | 19 |
| GO:MF | GO:0102571 | [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity | "Catalysis of the reaction: 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl/L-threonyl-[protein] + H2O = L-seryl//L-threonyl-[protein] + N-acetyl-D-glucosamine." [EC:3.2.1.169] | 1 | 0.049891 | 19 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0010494 | cytoplasmic stress granule | "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] | 4 | 8.008493e-07 | 20 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 4 | 4.887881e-05 | 20 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 4 | 6.496181e-05 | 20 |
| GO:CC | GO:0070937 | CRD-mediated mRNA stability complex | "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9." [GOC:mah, PMID:19029303] | 2 | 1.691669e-04 | 20 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 6 | 4.479479e-02 | 20 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 4 | 4.524656e-02 | 20 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 4 | 0.000329 | 20 |
| GO:MF | GO:0043021 | ribonucleoprotein complex binding | "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] | 3 | 0.002061 | 20 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 6 | 0.002123 | 20 |
| GO:MF | GO:0045182 | translation regulator activity | "Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] | 2 | 0.023117 | 20 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902373 | negative regulation of mRNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865] | 3 | 0.000904 | 20 |
| GO:BP | GO:1902369 | negative regulation of RNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] | 3 | 0.001387 | 20 |
| GO:BP | GO:1903312 | negative regulation of mRNA metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 3 | 0.001958 | 20 |
| GO:BP | GO:0061157 | mRNA destabilization | "Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh] | 3 | 0.001958 | 20 |
| GO:BP | GO:0050779 | RNA destabilization | "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai] | 3 | 0.002200 | 20 |
| GO:BP | GO:0061014 | positive regulation of mRNA catabolic process | "Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 3 | 0.002263 | 20 |
| GO:BP | GO:0070934 | CRD-mediated mRNA stabilization | "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] | 2 | 0.003329 | 20 |
| GO:BP | GO:1900152 | negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] | 2 | 0.003994 | 20 |
| GO:BP | GO:0045727 | positive regulation of translation | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] | 3 | 0.004869 | 20 |
| GO:BP | GO:1903313 | positive regulation of mRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 3 | 0.005534 | 20 |
| GO:BP | GO:2000767 | positive regulation of cytoplasmic translation | "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 2 | 0.007258 | 20 |
| GO:BP | GO:0043488 | regulation of mRNA stability | "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] | 3 | 0.010993 | 20 |
| GO:BP | GO:0043487 | regulation of RNA stability | "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] | 3 | 0.013324 | 20 |
| GO:BP | GO:0061013 | regulation of mRNA catabolic process | "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 3 | 0.014385 | 20 |
| GO:BP | GO:1900151 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] | 2 | 0.015289 | 20 |
| GO:BP | GO:0006402 | mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 3 | 0.032846 | 20 |
| GO:BP | GO:0034063 | stress granule assembly | "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519] | 2 | 0.033854 | 20 |
| GO:BP | GO:2000765 | regulation of cytoplasmic translation | "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 2 | 0.040175 | 20 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-3927-3p | hsa-mir-3927-3p | hsa-mir-3927-3p | 3 | 0.007121 | 20 |
| MIRNA | MIRNA:hsa-mir-6831-5p | hsa-mir-6831-5p | hsa-mir-6831-5p | 3 | 0.007391 | 20 |
| MIRNA | MIRNA:hsa-mir-875-3p | hsa-mir-875-3p | hsa-mir-875-3p | 5 | 0.012065 | 20 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0130653 | Colon; fibroblasts[High] | Colon; fibroblasts[High] | 2 | 0.011438 | 21 |
| HPA | HPA:0400653 | Rectum; fibroblasts[High] | Rectum; fibroblasts[High] | 2 | 0.013986 | 21 |
| HPA | HPA:0130652 | Colon; fibroblasts[≥Medium] | Colon; fibroblasts[≥Medium] | 2 | 0.032525 | 21 |
| HPA | HPA:0400203 | Rectum; endothelial cells[High] | Rectum; endothelial cells[High] | 2 | 0.036713 | 21 |
| HPA | HPA:0151343 | Duodenum; glands of Brunner[High] | Duodenum; glands of Brunner[High] | 2 | 0.038165 | 21 |
| HPA | HPA:0130651 | Colon; fibroblasts[≥Low] | Colon; fibroblasts[≥Low] | 2 | 0.039645 | 21 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 2 | 0.041152 | 21 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005875 | microtubule associated complex | "Any multimeric complex connected to a microtubule." [GOC:jl] | 3 | 0.000795 | 22 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 4 | 0.002022 | 22 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 4 | 0.005719 | 22 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 4 | 0.005891 | 22 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 4 | 0.019078 | 22 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 3 | 0.023313 | 22 |
| GO:CC | GO:0044304 | main axon | "The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites." [NIF_Subcellular:sao1596975044] | 2 | 0.024205 | 22 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 4 | 0.033094 | 22 |
| GO:CC | GO:0044297 | cell body | "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] | 3 | 0.035714 | 22 |
| GO:CC | GO:0098978 | glutamatergic synapse | "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] | 3 | 0.042432 | 22 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 5 | 0.001604 | 22 |
| GO:BP | GO:0016358 | dendrite development | "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] | 3 | 0.011750 | 22 |
| GO:BP | GO:0099173 | postsynapse organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse." [GOC:dos] | 3 | 0.012341 | 22 |
| GO:BP | GO:0000902 | cell morphogenesis | "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] | 4 | 0.019116 | 22 |
| GO:BP | GO:0031114 | regulation of microtubule depolymerization | "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah] | 2 | 0.021297 | 22 |
| GO:BP | GO:0045773 | positive regulation of axon extension | "Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators] | 2 | 0.025156 | 22 |
| GO:BP | GO:0007019 | microtubule depolymerization | "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] | 2 | 0.043784 | 22 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 4 | 0.005777 | 22 |
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 3 | 0.020249 | 22 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03250 | Viral life cycle - HIV-1 | Viral life cycle - HIV-1 | 2 | 0.016774 | 22 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5265 | Neurogenesis regulation in the olfactory epithelium | Neurogenesis regulation in the olfactory epithelium | 2 | 0.020944 | 22 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7235 | DISC1-DRD2 complex | DISC1-DRD2 complex | 1 | 0.024966 | 22 |
| CORUM | CORUM:7346 | DISC1-RHOT1 complex | DISC1-RHOT1 complex | 1 | 0.049932 | 22 |
| CORUM | CORUM:6041 | DISC1-FEZ1 complex | DISC1-FEZ1 complex | 1 | 0.049932 | 22 |
| CORUM | CORUM:6043 | DISC-FEZ1-F-actin complex | DISC-FEZ1-F-actin complex | 1 | 0.049932 | 22 |
| CORUM | CORUM:6046 | PDE4B-DISC1 complex | PDE4B-DISC1 complex | 1 | 0.049932 | 22 |
| CORUM | CORUM:6061 | DISC1-ZNF365 complex | DISC1-ZNF365 complex | 1 | 0.049932 | 22 |
| CORUM | CORUM:7345 | DISC1-TRAK1 complex | DISC1-TRAK1 complex | 1 | 0.049932 | 22 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0090923 | Cerebellum; GLUC cells - cytoplasm/membrane[High] | Cerebellum; GLUC cells - cytoplasm/membrane[High] | 2 | 0.039645 | 22 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6823 | CP–LF–MPO complex | CP–LF–MPO complex | 2 | 0.000089 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097013 | phagocytic vesicle lumen | "The volume enclosed by the membrane of a phagocytic vesicle." [GOC:rs] | 2 | 0.000090 | 23 |
| GO:CC | GO:0071682 | endocytic vesicle lumen | "The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde] | 2 | 0.002278 | 23 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 3 | 0.006652 | 23 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 3 | 0.006964 | 23 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 3 | 0.007028 | 23 |
| GO:CC | GO:1904724 | tertiary granule lumen | "Any membrane-enclosed lumen that is part of a tertiary granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 2 | 0.013331 | 23 |
| GO:CC | GO:0035580 | specific granule lumen | "The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:bf, PMID:7334549] | 2 | 0.016419 | 23 |
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 2 | 0.036641 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0042742 | defense response to bacterium | "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] | 3 | 0.030245 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 3 | 0.040229 | 23 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9010642 | ROBO receptors bind AKAP5 | ROBO receptors bind AKAP5 | 3 | 4.619695e-08 | 24 |
| REAC | REAC:R-HSA-111933 | Calmodulin induced events | Calmodulin induced events | 3 | 4.936474e-06 | 24 |
| REAC | REAC:R-HSA-111997 | CaM pathway | CaM pathway | 3 | 4.936474e-06 | 24 |
| REAC | REAC:R-HSA-111996 | Ca-dependent events | Ca-dependent events | 3 | 5.890111e-06 | 24 |
| REAC | REAC:R-HSA-1489509 | DAG and IP3 signaling | DAG and IP3 signaling | 3 | 8.150462e-06 | 24 |
| REAC | REAC:R-HSA-112043 | PLC beta mediated events | PLC beta mediated events | 3 | 1.426826e-05 | 24 |
| REAC | REAC:R-HSA-112040 | G-protein mediated events | G-protein mediated events | 3 | 1.932517e-05 | 24 |
| REAC | REAC:R-HSA-422356 | Regulation of insulin secretion | Regulation of insulin secretion | 3 | 6.275856e-05 | 24 |
| REAC | REAC:R-HSA-111885 | Opioid Signalling | Opioid Signalling | 3 | 9.052622e-05 | 24 |
| REAC | REAC:R-HSA-163685 | Integration of energy metabolism | Integration of energy metabolism | 3 | 1.637393e-04 | 24 |
| REAC | REAC:R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | CREB1 phosphorylation through the activation of Adenylate Cyclase | 2 | 4.989106e-04 | 24 |
| REAC | REAC:R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | Neurotransmitter receptors and postsynaptic signal transmission | 3 | 1.003847e-03 | 24 |
| REAC | REAC:R-HSA-164378 | PKA activation in glucagon signalling | PKA activation in glucagon signalling | 2 | 1.233221e-03 | 24 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 3 | 1.385562e-03 | 24 |
| REAC | REAC:R-HSA-163615 | PKA activation | PKA activation | 2 | 1.387289e-03 | 24 |
| REAC | REAC:R-HSA-111931 | PKA-mediated phosphorylation of CREB | PKA-mediated phosphorylation of CREB | 2 | 1.550406e-03 | 24 |
| REAC | REAC:R-HSA-180024 | DARPP-32 events | DARPP-32 events | 2 | 2.293319e-03 | 24 |
| REAC | REAC:R-HSA-112315 | Transmission across Chemical Synapses | Transmission across Chemical Synapses | 3 | 2.333817e-03 | 24 |
| REAC | REAC:R-HSA-9006925 | Intracellular signaling by second messengers | Intracellular signaling by second messengers | 3 | 3.388035e-03 | 24 |
| REAC | REAC:R-HSA-418594 | G alpha (i) signalling events | G alpha (i) signalling events | 3 | 4.095949e-03 | 24 |
| REAC | REAC:R-HSA-163359 | Glucagon signaling in metabolic regulation | Glucagon signaling in metabolic regulation | 2 | 4.783153e-03 | 24 |
| REAC | REAC:R-HSA-8853659 | RET signaling | RET signaling | 2 | 6.366545e-03 | 24 |
| REAC | REAC:R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 2 | 7.795539e-03 | 24 |
| REAC | REAC:R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | ADORA2B mediated anti-inflammatory cytokines production | 2 | 7.795539e-03 | 24 |
| REAC | REAC:R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | Vasopressin regulates renal water homeostasis via Aquaporins | 2 | 8.175312e-03 | 24 |
| REAC | REAC:R-HSA-9634597 | GPER1 signaling | GPER1 signaling | 2 | 8.564093e-03 | 24 |
| REAC | REAC:R-HSA-112316 | Neuronal System | Neuronal System | 3 | 8.668032e-03 | 24 |
| REAC | REAC:R-HSA-445717 | Aquaporin-mediated transport | Aquaporin-mediated transport | 2 | 1.199838e-02 | 24 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 3 | 2.189124e-02 | 24 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 3 | 2.506235e-02 | 24 |
| REAC | REAC:R-HSA-438064 | Post NMDA receptor activation events | Post NMDA receptor activation events | 2 | 2.507463e-02 | 24 |
| REAC | REAC:R-HSA-388396 | GPCR downstream signalling | GPCR downstream signalling | 3 | 3.292666e-02 | 24 |
| REAC | REAC:R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | Activation of NMDA receptors and postsynaptic events | 2 | 3.456207e-02 | 24 |
| REAC | REAC:R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | FCGR3A-mediated IL10 synthesis | 2 | 3.778515e-02 | 24 |
| REAC | REAC:R-HSA-4420097 | VEGFA-VEGFR2 Pathway | VEGFA-VEGFR2 Pathway | 2 | 3.945026e-02 | 24 |
| REAC | REAC:R-HSA-109582 | Hemostasis | Hemostasis | 3 | 4.209716e-02 | 24 |
| REAC | REAC:R-HSA-372790 | Signaling by GPCR | Signaling by GPCR | 3 | 4.595699e-02 | 24 |
| REAC | REAC:R-HSA-194138 | Signaling by VEGF | Signaling by VEGF | 2 | 4.831088e-02 | 24 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP35 | G protein signaling | G protein signaling | 4 | 8.441259e-07 | 24 |
| WP | WP:WP5440 | EPAC1 and PKA reduction of retinal inflammation | EPAC1 and PKA reduction of retinal inflammation | 2 | 3.701906e-04 | 24 |
| WP | WP:WP4540 | Hippo signaling regulation | Hippo signaling regulation | 3 | 4.563027e-04 | 24 |
| WP | WP:WP536 | Calcium regulation in cardiac cells | Calcium regulation in cardiac cells | 3 | 1.646520e-03 | 24 |
| WP | WP:WP289 | Myometrial relaxation and contraction pathways | Myometrial relaxation and contraction pathways | 3 | 1.782102e-03 | 24 |
| WP | WP:WP5503 | Albuterol and budesonide therapy for asthma | Albuterol and budesonide therapy for asthma | 2 | 4.285074e-03 | 24 |
| WP | WP:WP3965 | Lipid metabolism pathway | Lipid metabolism pathway | 2 | 5.350595e-03 | 24 |
| WP | WP:WP5344 | Cardiomyocyte signaling converging on titin | Cardiomyocyte signaling converging on titin | 2 | 6.954161e-03 | 24 |
| WP | WP:WP2636 | Common pathways underlying drug addiction | Common pathways underlying drug addiction | 2 | 1.078683e-02 | 24 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005952 | cAMP-dependent protein kinase complex | "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [PMID:18178622] | 2 | 0.000122 | 24 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 4 | 0.000351 | 24 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 4 | 0.002431 | 24 |
| GO:CC | GO:0097546 | ciliary base | "Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444] | 2 | 0.003643 | 24 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 3 | 0.020498 | 24 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 4 | 0.021454 | 24 |
| GO:CC | GO:0005929 | cilium | "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] | 3 | 0.024220 | 24 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 2 | 0.032139 | 24 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 2 | 0.038932 | 24 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004691 | cAMP-dependent protein kinase activity | "cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [PMID:32935175, PMID:35053423, PMID:35805104] | 2 | 0.001004 | 24 |
| GO:MF | GO:0004690 | cyclic nucleotide-dependent protein kinase activity | "cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah] | 2 | 0.001263 | 24 |
| GO:MF | GO:0051018 | protein kinase A binding | "Binding to a protein kinase A." [GOC:ai] | 2 | 0.010543 | 24 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 3 | 0.020494 | 24 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 4 | 0.029546 | 24 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05110 | Vibrio cholerae infection | Vibrio cholerae infection | 2 | 0.005037 | 24 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | Endocrine and other factor-regulated calcium reabsorption | 2 | 0.005664 | 24 |
| KEGG | KEGG:04720 | Long-term potentiation | Long-term potentiation | 2 | 0.009078 | 24 |
| KEGG | KEGG:05031 | Amphetamine addiction | Amphetamine addiction | 2 | 0.009631 | 24 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | Thyroid hormone synthesis | 2 | 0.011387 | 24 |
| KEGG | KEGG:04971 | Gastric acid secretion | Gastric acid secretion | 2 | 0.011694 | 24 |
| KEGG | KEGG:04911 | Insulin secretion | Insulin secretion | 2 | 0.014638 | 24 |
| KEGG | KEGG:04540 | Gap junction | Gap junction | 2 | 0.015692 | 24 |
| KEGG | KEGG:05032 | Morphine addiction | Morphine addiction | 2 | 0.016051 | 24 |
| KEGG | KEGG:04727 | GABAergic synapse | GABAergic synapse | 2 | 0.016051 | 24 |
| KEGG | KEGG:04970 | Salivary secretion | Salivary secretion | 2 | 0.016782 | 24 |
| KEGG | KEGG:04912 | GnRH signaling pathway | GnRH signaling pathway | 2 | 0.017530 | 24 |
| KEGG | KEGG:04713 | Circadian entrainment | Circadian entrainment | 2 | 0.019073 | 24 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | Aldosterone synthesis and secretion | 2 | 0.019468 | 24 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | Inflammatory mediator regulation of TRP channels | 2 | 0.019468 | 24 |
| KEGG | KEGG:05146 | Amoebiasis | Amoebiasis | 2 | 0.020680 | 24 |
| KEGG | KEGG:04916 | Melanogenesis | Melanogenesis | 2 | 0.020680 | 24 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | Parathyroid hormone synthesis, secretion and action | 2 | 0.022352 | 24 |
| KEGG | KEGG:04726 | Serotonergic synapse | Serotonergic synapse | 2 | 0.025433 | 24 |
| KEGG | KEGG:04725 | Cholinergic synapse | Cholinergic synapse | 2 | 0.025889 | 24 |
| KEGG | KEGG:04724 | Glutamatergic synapse | Glutamatergic synapse | 2 | 0.026813 | 24 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | Growth hormone synthesis, secretion and action | 2 | 0.029195 | 24 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | Thyroid hormone signaling pathway | 2 | 0.029683 | 24 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | Relaxin signaling pathway | 2 | 0.033734 | 24 |
| KEGG | KEGG:04728 | Dopaminergic synapse | Dopaminergic synapse | 2 | 0.034786 | 24 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | Vascular smooth muscle contraction | 2 | 0.035855 | 24 |
| KEGG | KEGG:04910 | Insulin signaling pathway | Insulin signaling pathway | 2 | 0.038041 | 24 |
| KEGG | KEGG:04723 | Retrograde endocannabinoid signaling | Retrograde endocannabinoid signaling | 2 | 0.044380 | 24 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | Adrenergic signaling in cardiomyocytes | 2 | 0.047421 | 24 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | Oxytocin signaling pathway | 2 | 0.048041 | 24 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0003091 | renal water homeostasis | "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio] | 2 | 0.005421 | 24 |
| GO:BP | GO:0050891 | multicellular organismal-level water homeostasis | "A chemical homeostatic process involved in the maintenance of a steady state level of water within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." [GOC:dph, GOC:tb] | 2 | 0.010132 | 24 |
| GO:BP | GO:0050878 | regulation of body fluid levels | "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb] | 3 | 0.014929 | 24 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-180746 | Nuclear import of Rev protein | Nuclear import of Rev protein | 3 | 0.000014 | 25 |
| REAC | REAC:R-HSA-177243 | Interactions of Rev with host cellular proteins | Interactions of Rev with host cellular proteins | 3 | 0.000018 | 25 |
| REAC | REAC:R-HSA-162909 | Host Interactions of HIV factors | Host Interactions of HIV factors | 3 | 0.001009 | 25 |
| REAC | REAC:R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | Postmitotic nuclear pore complex (NPC) reformation | 2 | 0.004624 | 25 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 3 | 0.005709 | 25 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 3 | 0.005862 | 25 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 3 | 0.005939 | 25 |
| REAC | REAC:R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | Transport of Ribonucleoproteins into the Host Nucleus | 2 | 0.006798 | 25 |
| REAC | REAC:R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | Rev-mediated nuclear export of HIV RNA | 2 | 0.008302 | 25 |
| REAC | REAC:R-HSA-168276 | NS1 Mediated Effects on Host Pathways | NS1 Mediated Effects on Host Pathways | 2 | 0.011758 | 25 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 3 | 0.033122 | 25 |
| REAC | REAC:R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | Nuclear Envelope (NE) Reassembly | 2 | 0.040235 | 25 |
| REAC | REAC:R-HSA-1169408 | ISG15 antiviral mechanism | ISG15 antiviral mechanism | 2 | 0.041396 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0031267 | small GTPase binding | "Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782] | 3 | 0.005472 | 25 |
| GO:MF | GO:0051020 | GTPase binding | "Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai] | 3 | 0.007520 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006607 | NLS-bearing protein import into nucleus | "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope." [GOC:ai] | 2 | 0.00613 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005643 | nuclear pore | "A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] | 2 | 0.015642 | 25 |
| GO:CC | GO:1990723 | cytoplasmic periphery of the nuclear pore complex | "Cytoplasm situated in close proximity to a nuclear pore complex." [PMID:9398662] | 1 | 0.049885 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | Nucleocytoplasmic transport | 2 | 0.023648 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7543 | KPNB1-SMN-SPN complex | KPNB1-SMN-SPN complex | 1 | 0.049932 | 25 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9646399 | Aggrephagy | Aggrephagy | 2 | 0.030769 | 26 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05988 | Factor: ZNF860; motif: NTGGGAAAWGSM | Factor: ZNF860; motif: NTGGGAAAWGSM | 2 | 0.042844 | 26 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0007525 | Yellow subcutaneous tissue covered by thin, scaly skin | Yellow subcutaneous tissue covered by thin, scaly skin | 1 | 0.049962 | 26 |
| HP | HP:0034691 | Reduced 3-phosphoglycerate dehydrogenase activity | Diminished activity of the enzyme 3-phosphoglycerate dehydrogenase (PGDH), which catalyzes the first step in the pathway by converting D-3-phosphoglycerate (PGA), an intermediate in glycolysis, to phosphohydroxypyruvate concomitant with the reduction of NAD+. | 1 | 0.049962 | 26 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004617 | phosphoglycerate dehydrogenase activity | "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] | 1 | 0.049992 | 26 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 4 | 0.007910 | 27 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 4 | 0.008824 | 27 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 4 | 0.011130 | 27 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 4 | 0.028439 | 27 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 4 | 0.031856 | 27 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 4 | 0.032878 | 27 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 4 | 0.037816 | 27 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5401 | PLEKHM2-KIF5B complex | PLEKHM2-KIF5B complex | 1 | 0.049932 | 27 |
| CORUM | CORUM:6552 | KIF5B-SPG33 complex | KIF5B-SPG33 complex | 1 | 0.049932 | 27 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:6000430 | Reduced tissue acetyl-CoA carboxylase activity | Activity of acetyl-CoA carboxylase in the tissues below the lower limit of normal. The activity can be measured in multiple tissues including liver. | 1 | 0.049962 | 27 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5218920 | VEGFR2 mediated vascular permeability | VEGFR2 mediated vascular permeability | 2 | 0.003181 | 28 |
| REAC | REAC:R-HSA-389356 | Co-stimulation by CD28 | Co-stimulation by CD28 | 2 | 0.004213 | 28 |
| REAC | REAC:R-HSA-388841 | Regulation of T cell activation by CD28 family | Regulation of T cell activation by CD28 family | 2 | 0.019988 | 28 |
| REAC | REAC:R-HSA-5628897 | TP53 Regulates Metabolic Genes | TP53 Regulates Metabolic Genes | 2 | 0.031482 | 28 |
| REAC | REAC:R-HSA-4420097 | VEGFA-VEGFR2 Pathway | VEGFA-VEGFR2 Pathway | 2 | 0.039450 | 28 |
| REAC | REAC:R-HSA-194138 | Signaling by VEGF | Signaling by VEGF | 2 | 0.048311 | 28 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4564 | Neural crest cell migration during development | Neural crest cell migration during development | 2 | 0.003779 | 28 |
| WP | WP:WP4565 | Neural crest cell migration in cancer | Neural crest cell migration in cancer | 2 | 0.004389 | 28 |
| WP | WP:WP4205 | MET in type 1 papillary renal cell carcinoma | MET in type 1 papillary renal cell carcinoma | 2 | 0.008417 | 28 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 2 | 0.019447 | 28 |
| WP | WP:WP673 | ErbB signaling | ErbB signaling | 2 | 0.019892 | 28 |
| WP | WP:WP185 | Integrin mediated cell adhesion | Integrin mediated cell adhesion | 2 | 0.025629 | 28 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05211 | Renal cell carcinoma | Renal cell carcinoma | 2 | 0.009353 | 28 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | Central carbon metabolism in cancer | 2 | 0.009914 | 28 |
| KEGG | KEGG:04012 | ErbB signaling pathway | ErbB signaling pathway | 2 | 0.014295 | 28 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | T cell receptor signaling pathway | 2 | 0.028710 | 28 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] | 2 | 0.023034 | 28 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] | 2 | 0.024738 | 28 |
| GO:BP | GO:0014896 | muscle hypertrophy | "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle] | 2 | 0.025907 | 28 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-503 | hsa-mir-503 | hsa-mir-503 | 3 | 0.046321 | 28 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3138 | POSH-AKT2 complex | POSH-AKT2 complex | 1 | 0.049932 | 28 |
| CORUM | CORUM:3848 | TCL1(trimer)-AKT2 complex | TCL1(trimer)-AKT2 complex | 1 | 0.049932 | 28 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4085023 | Defective GFPT1 causes CMSTA1 | Defective GFPT1 causes CMSTA1 | 1 | 0.049932 | 29 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031461 | cullin-RING ubiquitin ligase complex | "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] | 3 | 0.000341 | 30 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 3 | 0.001679 | 30 |
| GO:CC | GO:0019005 | SCF ubiquitin ligase complex | "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] | 2 | 0.007001 | 30 |
| GO:CC | GO:0097409 | glial cytoplasmic inclusion | "Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy." [NIF_Subcellular:nlx_subcell_20090703, PMID:21562886, PMID:2559165] | 1 | 0.024944 | 30 |
| GO:CC | GO:0097414 | classical Lewy body | "Cytoplasmic inclusion, 5 to 15 micrometers in diameter, with a dense core surrounded by a halo of 10 to 20 nm wide radially oriented alpha-synuclein fibrils." [NIF_Subcellular:sao4749542545] | 1 | 0.024944 | 30 |
| GO:CC | GO:0097462 | Lewy neurite | "Elongated neuronal process, often with side branches and more than one branching point, described in brains of patients with Parkinson's disease. Lewy neurites stain positively for ubiquitin in brainstem and forebrain regions affected in Parkinson's disease." [NIF_Subcellular:sao601362597] | 1 | 0.024944 | 30 |
| GO:CC | GO:1990038 | Lewy body corona | "The periphery of a Lewy body. In Parkinson's disease, it contains spherical accumulations of filaments arranged in a loose, radiating array." [NIF_Subcellular:sao5764355747] | 1 | 0.024944 | 30 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 3 | 0.037022 | 30 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 3 | 0.041545 | 30 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity | "The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274] | 2 | 0.015792 | 30 |
| GO:MF | GO:0140767 | enzyme-substrate adaptor activity | "An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity." [PMID:16250895, PMID:34358446] | 2 | 0.022663 | 30 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 3 | 0.019916 | 30 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 3 | 0.044803 | 30 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5805 | PGAM5-KEAP1-NRF2 complex | PGAM5-KEAP1-NRF2 complex | 2 | 0.000089 | 31 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3953 | mRNA protein and metabolite inducation pathway by cyclosporin A | mRNA protein and metabolite inducation pathway by cyclosporin A | 2 | 0.000107 | 31 |
| WP | WP:WP3 | Transcriptional activation by NRF2 in response to phytochemicals | Transcriptional activation by NRF2 in response to phytochemicals | 2 | 0.000536 | 31 |
| WP | WP:WP2435 | Quercetin and Nf kB AP 1 induced apoptosis | Quercetin and Nf kB AP 1 induced apoptosis | 2 | 0.000613 | 31 |
| WP | WP:WP4206 | Hereditary leiomyomatosis and renal cell carcinoma pathway | Hereditary leiomyomatosis and renal cell carcinoma pathway | 2 | 0.000970 | 31 |
| WP | WP:WP3612 | Photodynamic therapy induced NFE2L2 NRF2 survival signaling | Photodynamic therapy induced NFE2L2 NRF2 survival signaling | 2 | 0.001292 | 31 |
| WP | WP:WP4357 | NRF2 ARE regulation | NRF2 ARE regulation | 2 | 0.001292 | 31 |
| WP | WP:WP5113 | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway | 2 | 0.002531 | 31 |
| WP | WP:WP5477 | Molecular pathway for oxidative stress | Molecular pathway for oxidative stress | 2 | 0.005992 | 31 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 2 | 0.013736 | 31 |
| WP | WP:WP4874 | CAMKK2 pathway | CAMKK2 pathway | 2 | 0.030404 | 31 |
| WP | WP:WP2884 | NRF2 pathway | NRF2 pathway | 2 | 0.049937 | 31 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902882 | regulation of response to oxidative stress | "Any process that modulates the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] | 2 | 0.010132 | 31 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 4 | 0.012573 | 31 |
| GO:BP | GO:0045595 | regulation of cell differentiation | "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] | 4 | 0.020969 | 31 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 4 | 0.021849 | 31 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 3 | 0.025458 | 31 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | Fluid shear stress and atherosclerosis | 2 | 0.038597 | 31 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0110016 | B-WICH complex | "A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself." [GOC:bhm, PMID:16603771, PMID:21559432, PMID:23555303, PMID:26044184] | 2 | 0.000095 | 32 |
| GO:CC | GO:0000792 | heterochromatin | "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] | 2 | 0.011442 | 32 |
| GO:CC | GO:0070603 | SWI/SNF superfamily-type complex | "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938] | 2 | 0.015002 | 32 |
| GO:CC | GO:0034693 | U11/U12 snRNP | "A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins." [GOC:mah, PMID:15146077] | 1 | 0.024944 | 32 |
| GO:CC | GO:1904949 | ATPase complex | "A protein complex which is capable of ATPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181] | 2 | 0.027254 | 32 |
| GO:CC | GO:0016590 | ACF complex | "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:12192034, PMID:15284901, PMID:16568949, PMID:21810179] | 1 | 0.049885 | 32 |
| GO:CC | GO:0090536 | NoRC complex | "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and a Tip5 homolog. In mammals, NoRC is involved in regulation of transcription from RNAP I and RNA polymerase III promoters." [GOC:krc] | 1 | 0.049885 | 32 |
| GO:CC | GO:0031213 | RSF complex | "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179] | 1 | 0.049885 | 32 |
| GO:CC | GO:0090535 | WICH complex | "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair." [GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179] | 1 | 0.049885 | 32 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6194 | B-WICH complex | B-WICH complex | 2 | 0.000413 | 32 |
| CORUM | CORUM:6302 | B-WICH complex | B-WICH complex | 2 | 0.000532 | 32 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045945 | positive regulation of transcription by RNA polymerase III | "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators, GOC:txnOH] | 2 | 0.003091 | 32 |
| GO:BP | GO:0006359 | regulation of transcription by RNA polymerase III | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III." [GOC:go_curators] | 2 | 0.008399 | 32 |
| GO:BP | GO:0045943 | positive regulation of transcription by RNA polymerase I | "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH] | 2 | 0.010745 | 32 |
| GO:BP | GO:0030261 | chromosome condensation | "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] | 2 | 0.017867 | 32 |
| GO:BP | GO:0006356 | regulation of transcription by RNA polymerase I | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators] | 2 | 0.019507 | 32 |
| GO:BP | GO:0006383 | transcription by RNA polymerase III | "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659] | 2 | 0.034091 | 32 |
| GO:BP | GO:0006360 | transcription by RNA polymerase I | "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] | 2 | 0.044774 | 32 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5352 | 10q11 21q11 23 copy number variation syndrome | 10q11 21q11 23 copy number variation syndrome | 2 | 0.009011 | 32 |
| WP | WP:WP4932 | 7q11 23 copy number variation syndrome | 7q11 23 copy number variation syndrome | 2 | 0.028767 | 32 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | B-WICH complex positively regulates rRNA expression | 2 | 0.035354 | 32 |
| REAC | REAC:R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | Positive epigenetic regulation of rRNA expression | 2 | 0.048311 | 32 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0031491 | nucleosome binding | "Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] | 2 | 0.03636 | 32 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-493-5p | hsa-mir-493-5p | hsa-mir-493-5p | 2 | 0.049683 | 32 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007098 | centrosome cycle | "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] | 4 | 0.000001 | 33 |
| GO:BP | GO:0010968 | regulation of microtubule nucleation | "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] | 3 | 0.000002 | 33 |
| GO:BP | GO:0031023 | microtubule organizing center organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] | 4 | 0.000002 | 33 |
| GO:BP | GO:0007051 | spindle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] | 4 | 0.000006 | 33 |
| GO:BP | GO:0032886 | regulation of microtubule-based process | "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] | 4 | 0.000017 | 33 |
| GO:BP | GO:0007020 | microtubule nucleation | "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712] | 3 | 0.000026 | 33 |
| GO:BP | GO:0031113 | regulation of microtubule polymerization | "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah] | 3 | 0.000072 | 33 |
| GO:BP | GO:0046785 | microtubule polymerization | "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] | 3 | 0.000261 | 33 |
| GO:BP | GO:0031110 | regulation of microtubule polymerization or depolymerization | "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] | 3 | 0.000261 | 33 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 4 | 0.000634 | 33 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 4 | 0.000681 | 33 |
| GO:BP | GO:0051225 | spindle assembly | "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] | 3 | 0.000703 | 33 |
| GO:BP | GO:0031109 | microtubule polymerization or depolymerization | "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] | 3 | 0.000734 | 33 |
| GO:BP | GO:0070507 | regulation of microtubule cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 3 | 0.001235 | 33 |
| GO:BP | GO:0032271 | regulation of protein polymerization | "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 3 | 0.002212 | 33 |
| GO:BP | GO:0007017 | microtubule-based process | "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] | 4 | 0.003378 | 33 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 4 | 0.003543 | 33 |
| GO:BP | GO:0070925 | organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 4 | 0.004061 | 33 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 4 | 0.005895 | 33 |
| GO:BP | GO:0051258 | protein polymerization | "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] | 3 | 0.006438 | 33 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 4 | 0.009116 | 33 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 3 | 0.015777 | 33 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 4 | 0.018575 | 33 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] | 3 | 0.020940 | 33 |
| GO:BP | GO:0007059 | chromosome segregation | "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] | 3 | 0.021846 | 33 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 3 | 0.022308 | 33 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 4 | 0.026002 | 33 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 3 | 0.038696 | 33 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005819 | spindle | "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] | 4 | 0.000021 | 33 |
| GO:CC | GO:0070652 | HAUS complex | "A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217] | 2 | 0.000152 | 33 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 4 | 0.000176 | 33 |
| GO:CC | GO:0005875 | microtubule associated complex | "Any multimeric complex connected to a microtubule." [GOC:jl] | 3 | 0.000200 | 33 |
| GO:CC | GO:0072686 | mitotic spindle | "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] | 3 | 0.000315 | 33 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 4 | 0.000351 | 33 |
| GO:CC | GO:1990498 | mitotic spindle microtubule | "Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw] | 2 | 0.000405 | 33 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 4 | 0.002431 | 33 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 3 | 0.005920 | 33 |
| GO:CC | GO:0005876 | spindle microtubule | "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] | 2 | 0.011442 | 33 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 4 | 0.021454 | 33 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 3 | 0.027361 | 33 |
| GO:CC | GO:0005814 | centriole | "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] | 2 | 0.043639 | 33 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-380259 | Loss of Nlp from mitotic centrosomes | Loss of Nlp from mitotic centrosomes | 2 | 0.020593 | 33 |
| REAC | REAC:R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | Loss of proteins required for interphase microtubule organization from the centrosome | 2 | 0.020593 | 33 |
| REAC | REAC:R-HSA-8854518 | AURKA Activation by TPX2 | AURKA Activation by TPX2 | 2 | 0.022460 | 33 |
| REAC | REAC:R-HSA-380287 | Centrosome maturation | Centrosome maturation | 2 | 0.028545 | 33 |
| REAC | REAC:R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | Recruitment of mitotic centrosome proteins and complexes | 2 | 0.028545 | 33 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 2 | 0.032239 | 33 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 2 | 0.039450 | 33 |
| REAC | REAC:R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | Anchoring of the basal body to the plasma membrane | 2 | 0.041151 | 33 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4341 | Non genomic actions of 1 25 dihydroxyvitamin D3 | Non genomic actions of 1 25 dihydroxyvitamin D3 | 3 | 0.000195 | 34 |
| WP | WP:WP712 | Estrogen signaling | Estrogen signaling | 2 | 0.003337 | 34 |
| WP | WP:WP5036 | Angiotensin II receptor type 1 pathway | Angiotensin II receptor type 1 pathway | 2 | 0.004982 | 34 |
| WP | WP:WP2875 | Constitutive androstane receptor pathway | Constitutive androstane receptor pathway | 2 | 0.005732 | 34 |
| WP | WP:WP3414 | Initiation of transcription and translation elongation at the HIV 1 LTR | Initiation of transcription and translation elongation at the HIV 1 LTR | 2 | 0.006534 | 34 |
| WP | WP:WP2112 | IL17 signaling | IL17 signaling | 2 | 0.006534 | 34 |
| WP | WP:WP3995 | Prion disease pathway | Prion disease pathway | 2 | 0.006954 | 34 |
| WP | WP:WP5269 | Genetic causes of porto sinusoidal vascular disease | Genetic causes of porto sinusoidal vascular disease | 2 | 0.008766 | 34 |
| WP | WP:WP716 | Vitamin A and carotenoid metabolism | Vitamin A and carotenoid metabolism | 2 | 0.011324 | 34 |
| WP | WP:WP2795 | Cardiac hypertrophic response | Cardiac hypertrophic response | 2 | 0.018787 | 34 |
| WP | WP:WP4754 | IL18 signaling | IL18 signaling | 2 | 0.020212 | 34 |
| WP | WP:WP2324 | AGE RAGE pathway | AGE RAGE pathway | 2 | 0.028109 | 34 |
| WP | WP:WP5130 | Th17 cell differentiation pathway | Th17 cell differentiation pathway | 2 | 0.030729 | 34 |
| WP | WP:WP2034 | Leptin signaling | Leptin signaling | 2 | 0.032540 | 34 |
| WP | WP:WP4255 | Non small cell lung cancer | Non small cell lung cancer | 2 | 0.033464 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | Parathyroid hormone synthesis, secretion and action | 3 | 0.000392 | 34 |
| KEGG | KEGG:05216 | Thyroid cancer | Thyroid cancer | 2 | 0.005931 | 34 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 2 | 0.022637 | 34 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 2 | 0.039401 | 34 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | Choline metabolism in cancer | 2 | 0.041922 | 34 |
| KEGG | KEGG:04659 | Th17 cell differentiation | Th17 cell differentiation | 2 | 0.048105 | 34 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 3 | 0.048841 | 34 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | TGF-beta signaling pathway | 2 | 0.049948 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0031669 | cellular response to nutrient levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 3 | 0.004286 | 34 |
| GO:BP | GO:0001503 | ossification | "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] | 3 | 0.022308 | 34 |
| GO:BP | GO:0031667 | response to nutrient levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 3 | 0.037152 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4090294 | SUMOylation of intracellular receptors | SUMOylation of intracellular receptors | 2 | 0.004624 | 34 |
| REAC | REAC:R-HSA-8941326 | RUNX2 regulates bone development | RUNX2 regulates bone development | 2 | 0.007283 | 34 |
| REAC | REAC:R-HSA-2559585 | Oncogene Induced Senescence | Oncogene Induced Senescence | 2 | 0.008836 | 34 |
| REAC | REAC:R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2 | 0.010539 | 34 |
| REAC | REAC:R-HSA-9006931 | Signaling by Nuclear Receptors | Signaling by Nuclear Receptors | 3 | 0.011921 | 34 |
| REAC | REAC:R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | Activation of gene expression by SREBF (SREBP) | 2 | 0.013042 | 34 |
| REAC | REAC:R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2 | 0.020459 | 34 |
| REAC | REAC:R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2 | 0.023005 | 34 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 4 | 0.026689 | 34 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 4 | 0.038816 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 3 | 0.005021 | 34 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 3 | 0.013808 | 34 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 3 | 0.025458 | 34 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 4 | 0.029546 | 34 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 4 | 0.033986 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-449c | hsa-mir-449c | hsa-mir-449c | 4 | 0.006674 | 34 |
| MIRNA | MIRNA:hsa-mir-2682 | hsa-mir-2682 | hsa-mir-2682 | 4 | 0.006674 | 34 |
| MIRNA | MIRNA:hsa-mir-6859-3p | hsa-mir-6859-3p | hsa-mir-6859-3p | 2 | 0.012610 | 34 |
| MIRNA | MIRNA:hsa-mir-3692 | hsa-mir-3692 | hsa-mir-3692 | 4 | 0.013732 | 34 |
| MIRNA | MIRNA:hsa-mir-4691-3p | hsa-mir-4691-3p | hsa-mir-4691-3p | 4 | 0.016349 | 34 |
| MIRNA | MIRNA:hsa-mir-141 | hsa-mir-141 | hsa-mir-141 | 4 | 0.025915 | 34 |
| MIRNA | MIRNA:hsa-mir-200a | hsa-mir-200a | hsa-mir-200a | 4 | 0.025915 | 34 |
| MIRNA | MIRNA:hsa-mir-1205 | hsa-mir-1205 | hsa-mir-1205 | 4 | 0.030166 | 34 |
| MIRNA | MIRNA:hsa-mir-5190 | hsa-mir-5190 | hsa-mir-5190 | 2 | 0.036422 | 34 |
| MIRNA | MIRNA:hsa-mir-519e | hsa-mir-519e | hsa-mir-519e | 3 | 0.048319 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 3 | 0.007106 | 34 |
| GO:CC | GO:0017053 | transcription repressor complex | "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] | 2 | 0.010362 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 4 | 0.015220 | 34 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 3 | 0.027207 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:57 | HDAC4-ERK2 complex | HDAC4-ERK2 complex | 1 | 0.049932 | 34 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0290403 | Liver; hepatocytes[High] | Liver; hepatocytes[High] | 4 | 0.002805 | 35 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1905202 | methylcrotonoyl-CoA carboxylase complex | "A protein complex capable of methylcrotonoyl-CoA carboxylase activity. In mammals, it is a mitochondrial complex comprising a dodecamer of 6 alpha and 6 beta subunits: MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation; MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, GOC:PARL, PMID:15868465, PMID:17360195, PMID:22158123, PMID:22869039] | 1 | 0.049885 | 35 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097136 | Bcl-2 family protein complex | "A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed." [GOC:so, PMID:14634621] | 4 | 4.546611e-12 | 36 |
| GO:CC | GO:0005741 | mitochondrial outer membrane | "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] | 4 | 1.484320e-06 | 36 |
| GO:CC | GO:0031968 | organelle outer membrane | "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] | 4 | 2.484824e-06 | 36 |
| GO:CC | GO:0019867 | outer membrane | "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] | 4 | 2.563236e-06 | 36 |
| GO:CC | GO:0031966 | mitochondrial membrane | "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] | 4 | 2.219053e-04 | 36 |
| GO:CC | GO:0005740 | mitochondrial envelope | "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] | 4 | 2.837745e-04 | 36 |
| GO:CC | GO:0031967 | organelle envelope | "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] | 4 | 1.782790e-03 | 36 |
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 4 | 6.615951e-03 | 36 |
| GO:CC | GO:0098588 | bounding membrane of organelle | "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] | 4 | 1.469963e-02 | 36 |
| GO:CC | GO:0097144 | BAX complex | "An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] | 1 | 2.494407e-02 | 36 |
| GO:CC | GO:0097145 | BAK complex | "An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] | 1 | 4.988476e-02 | 36 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051434 | BH3 domain binding | "Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] | 3 | 1.460644e-08 | 36 |
| GO:MF | GO:0051400 | BH domain binding | "Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] | 3 | 1.606351e-07 | 36 |
| GO:MF | GO:0070513 | death domain binding | "Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531] | 3 | 2.088179e-07 | 36 |
| GO:MF | GO:0046982 | protein heterodimerization activity | "Binding to a nonidentical protein to form a heterodimer." [GOC:ai] | 3 | 5.697736e-03 | 36 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 3 | 3.322950e-02 | 36 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0001836 | release of cytochrome c from mitochondria | "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation." [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217] | 4 | 2.216898e-08 | 36 |
| GO:BP | GO:0008637 | apoptotic mitochondrial changes | "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis] | 4 | 3.620469e-07 | 36 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 4 | 3.236527e-06 | 36 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] | 4 | 9.301009e-06 | 36 |
| GO:BP | GO:0090199 | regulation of release of cytochrome c from mitochondria | "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 3 | 1.698616e-05 | 36 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 4 | 3.171328e-05 | 36 |
| GO:BP | GO:0046902 | regulation of mitochondrial membrane permeability | "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf] | 3 | 4.508028e-05 | 36 |
| GO:BP | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 3 | 5.879061e-05 | 36 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 4 | 7.002643e-05 | 36 |
| GO:BP | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708] | 3 | 7.859968e-05 | 36 |
| GO:BP | GO:0090559 | regulation of membrane permeability | "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane." [GOC:kmv, PMID:22677064] | 3 | 8.998492e-05 | 36 |
| GO:BP | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705] | 3 | 9.401074e-05 | 36 |
| GO:BP | GO:0051881 | regulation of mitochondrial membrane potential | "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai] | 3 | 1.024187e-04 | 36 |
| GO:BP | GO:0038034 | signal transduction in absence of ligand | "The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor." [GOC:al, GOC:ppm, GOC:pr, PMID:15044679] | 3 | 1.024187e-04 | 36 |
| GO:BP | GO:0007005 | mitochondrion organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] | 4 | 1.204916e-04 | 36 |
| GO:BP | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] | 3 | 1.635593e-04 | 36 |
| GO:BP | GO:1905897 | regulation of response to endoplasmic reticulum stress | "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] | 3 | 1.756586e-04 | 36 |
| GO:BP | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] | 3 | 3.215417e-04 | 36 |
| GO:BP | GO:0010821 | regulation of mitochondrion organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] | 3 | 4.233534e-04 | 36 |
| GO:BP | GO:0007006 | mitochondrial membrane organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 3 | 4.345774e-04 | 36 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 4 | 4.556048e-04 | 36 |
| GO:BP | GO:2001235 | positive regulation of apoptotic signaling pathway | "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 3 | 7.341801e-04 | 36 |
| GO:BP | GO:2001236 | regulation of extrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 3 | 1.062578e-03 | 36 |
| GO:BP | GO:0045837 | negative regulation of membrane potential | "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators] | 2 | 1.193619e-03 | 36 |
| GO:BP | GO:0010917 | negative regulation of mitochondrial membrane potential | "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb] | 2 | 1.193619e-03 | 36 |
| GO:BP | GO:0006839 | mitochondrial transport | "Transport of substances into, out of or within a mitochondrion." [GOC:ai] | 3 | 1.581054e-03 | 36 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 4 | 2.303965e-03 | 36 |
| GO:BP | GO:0035234 | ectopic germ cell programmed cell death | "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] | 2 | 2.765973e-03 | 36 |
| GO:BP | GO:2000811 | negative regulation of anoikis | "Any process that stops, prevents or reduces the frequency, rate or extent of anoikis." [GOC:obol] | 2 | 3.091186e-03 | 36 |
| GO:BP | GO:2001234 | negative regulation of apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 3 | 3.507728e-03 | 36 |
| GO:BP | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | "Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 2 | 3.795711e-03 | 36 |
| GO:BP | GO:0043523 | regulation of neuron apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] | 3 | 3.981856e-03 | 36 |
| GO:BP | GO:2000209 | regulation of anoikis | "Any process that modulates the frequency, rate or extent of anoikis." [GOC:mah] | 2 | 5.421068e-03 | 36 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 3 | 5.531653e-03 | 36 |
| GO:BP | GO:0010623 | programmed cell death involved in cell development | "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 2 | 5.872451e-03 | 36 |
| GO:BP | GO:0051402 | neuron apoptotic process | "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis] | 3 | 7.288838e-03 | 36 |
| GO:BP | GO:0008053 | mitochondrial fusion | "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774] | 2 | 9.536237e-03 | 36 |
| GO:BP | GO:1902235 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352] | 2 | 1.013161e-02 | 36 |
| GO:BP | GO:0043276 | anoikis | "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, PMID:37667281] | 2 | 1.074496e-02 | 36 |
| GO:BP | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis] | 2 | 1.202561e-02 | 36 |
| GO:BP | GO:1901099 | negative regulation of signal transduction in absence of ligand | "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand." [GOC:TermGenie] | 2 | 1.202561e-02 | 36 |
| GO:BP | GO:1902110 | positive regulation of mitochondrial membrane permeability involved in apoptotic process | "Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129] | 2 | 1.269289e-02 | 36 |
| GO:BP | GO:1905898 | positive regulation of response to endoplasmic reticulum stress | "Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] | 2 | 1.337815e-02 | 36 |
| GO:BP | GO:1902686 | mitochondrial outer membrane permeabilization involved in programmed cell death | "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie, PMID:20151314] | 2 | 1.408136e-02 | 36 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 4 | 1.552429e-02 | 36 |
| GO:BP | GO:0035794 | positive regulation of mitochondrial membrane permeability | "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf, PMID:12546810] | 2 | 1.554169e-02 | 36 |
| GO:BP | GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process | "Any regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129] | 2 | 1.707383e-02 | 36 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 4 | 1.748132e-02 | 36 |
| GO:BP | GO:1905710 | positive regulation of membrane permeability | "Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane." [PMID:27482894] | 2 | 1.867777e-02 | 36 |
| GO:BP | GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors | "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429] | 2 | 1.867777e-02 | 36 |
| GO:BP | GO:2001239 | regulation of extrinsic apoptotic signaling pathway in absence of ligand | "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis] | 2 | 1.950665e-02 | 36 |
| GO:BP | GO:0009615 | response to virus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:hb] | 3 | 1.991560e-02 | 36 |
| GO:BP | GO:0043029 | T cell homeostasis | "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149] | 2 | 2.121824e-02 | 36 |
| GO:BP | GO:0010332 | response to gamma radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators] | 2 | 2.392009e-02 | 36 |
| GO:BP | GO:0042391 | regulation of membrane potential | "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] | 3 | 2.694014e-02 | 36 |
| GO:BP | GO:0001541 | ovarian follicle development | "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] | 2 | 2.980757e-02 | 36 |
| GO:BP | GO:0043525 | positive regulation of neuron apoptotic process | "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] | 2 | 3.749073e-02 | 36 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 4 | 3.814043e-02 | 36 |
| GO:BP | GO:0080135 | regulation of cellular response to stress | "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 3 | 3.914526e-02 | 36 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 3 | 4.120783e-02 | 36 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 3 | 4.554631e-02 | 36 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 4 | 4.651224e-02 | 36 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 4 | 4.948573e-02 | 36 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3614 | Photodynamic therapy induced HIF 1 survival signaling | Photodynamic therapy induced HIF 1 survival signaling | 4 | 2.283327e-08 | 36 |
| WP | WP:WP254 | Apoptosis | Apoptosis | 4 | 7.695427e-07 | 36 |
| WP | WP:WP1772 | Apoptosis modulation and signaling | Apoptosis modulation and signaling | 4 | 8.833876e-07 | 36 |
| WP | WP:WP4864 | Host pathogen interaction of human coronaviruses apoptosis | Host pathogen interaction of human coronaviruses apoptosis | 3 | 4.016682e-06 | 36 |
| WP | WP:WP3872 | Apoptosis regulation by parathyroid hormone related protein | Apoptosis regulation by parathyroid hormone related protein | 3 | 6.111031e-06 | 36 |
| WP | WP:WP3611 | Photodynamic therapy induced AP 1 survival signaling | Photodynamic therapy induced AP 1 survival signaling | 3 | 5.904583e-05 | 36 |
| WP | WP:WP4318 | Mitochondrial fission and fusion | Mitochondrial fission and fusion | 2 | 1.030459e-03 | 36 |
| WP | WP:WP1742 | TP53 network | TP53 network | 2 | 2.257018e-03 | 36 |
| WP | WP:WP3657 | Hematopoietic stem cell gene regulation by GABP alpha beta complex | Hematopoietic stem cell gene regulation by GABP alpha beta complex | 2 | 2.507415e-03 | 36 |
| WP | WP:WP3982 | miRNA regulation of p53 pathway in prostate cancer | miRNA regulation of p53 pathway in prostate cancer | 2 | 6.126274e-03 | 36 |
| WP | WP:WP2447 | Amyotrophic lateral sclerosis ALS | Amyotrophic lateral sclerosis ALS | 2 | 9.251976e-03 | 36 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 2 | 3.072901e-02 | 36 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 2 | 3.440170e-02 | 36 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 2 | 3.440170e-02 | 36 |
| WP | WP:WP4806 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 2 | 4.555649e-02 | 36 |
| WP | WP:WP4298 | Acute viral myocarditis | Acute viral myocarditis | 2 | 4.664708e-02 | 36 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 2 | 4.999523e-02 | 36 |
| WP | WP:WP5098 | T cell activation SARS CoV 2 | T cell activation SARS CoV 2 | 2 | 4.999523e-02 | 36 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 4 | 0.000003 | 36 |
| KEGG | KEGG:04215 | Apoptosis - multiple species | Apoptosis - multiple species | 3 | 0.000010 | 36 |
| KEGG | KEGG:01524 | Platinum drug resistance | Platinum drug resistance | 3 | 0.000125 | 36 |
| KEGG | KEGG:04115 | p53 signaling pathway | p53 signaling pathway | 3 | 0.000136 | 36 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 2 | 0.025225 | 36 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 2 | 0.025225 | 36 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 2 | 0.027257 | 36 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 2 | 0.032299 | 36 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 2 | 0.036956 | 36 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 3 | 0.048841 | 36 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 3 | 0.000075 | 36 |
| REAC | REAC:R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 2 | 0.000604 | 36 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 3 | 0.002695 | 36 |
| REAC | REAC:R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2 | 0.003185 | 36 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 3 | 0.004451 | 36 |
| REAC | REAC:R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | TP53 Regulates Transcription of Cell Death Genes | 2 | 0.015810 | 36 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-181c-5p | hsa-mir-181c-5p | hsa-mir-181c-5p | 3 | 0.006360 | 36 |
| MIRNA | MIRNA:hsa-mir-125b-5p | hsa-mir-125b-5p | hsa-mir-125b-5p | 3 | 0.023474 | 36 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3492 | BAX homo-oligomer complex | BAX homo-oligomer complex | 1 | 0.049988 | 36 |
| CORUM | CORUM:2000 | BAX homo-oligomer complex | BAX homo-oligomer complex | 1 | 0.049988 | 36 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006413 | translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] | 4 | 8.462760e-07 | 37 |
| GO:BP | GO:0002183 | cytoplasmic translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] | 3 | 2.609258e-05 | 37 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 4 | 7.002643e-05 | 37 |
| GO:BP | GO:0006446 | regulation of translational initiation | "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] | 3 | 1.577235e-04 | 37 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 4 | 9.452651e-04 | 37 |
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 3 | 1.258227e-03 | 37 |
| GO:BP | GO:0001732 | formation of cytoplasmic translation initiation complex | "Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, PMID:29735639] | 2 | 2.169666e-03 | 37 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] | 4 | 4.754710e-03 | 37 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 4 | 4.026949e-02 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0031369 | translation initiation factor binding | "Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] | 3 | 0.000004 | 37 |
| GO:MF | GO:0003743 | translation initiation factor activity | "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] | 2 | 0.010154 | 37 |
| GO:MF | GO:0180051 | translation factor activity | "A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation." [GOC:pg] | 2 | 0.030098 | 37 |
| GO:MF | GO:0043022 | ribosome binding | "Binding to a ribosome." [GOC:go_curators] | 2 | 0.044812 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP107 | Translation factors | Translation factors | 3 | 0.000059 | 37 |
| WP | WP:WP5027 | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell | 2 | 0.001585 | 37 |
| WP | WP:WP2035 | Follicle stimulating hormone FSH signaling | Follicle stimulating hormone FSH signaling | 2 | 0.003640 | 37 |
| WP | WP:WP3879 | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression | 2 | 0.003956 | 37 |
| WP | WP:WP3844 | PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer | PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer | 2 | 0.006534 | 37 |
| WP | WP:WP3676 | BDNF TrkB signaling | BDNF TrkB signaling | 2 | 0.006954 | 37 |
| WP | WP:WP244 | Alpha 6 beta 4 signaling | Alpha 6 beta 4 signaling | 2 | 0.006954 | 37 |
| WP | WP:WP1471 | Target of rapamycin signaling | Target of rapamycin signaling | 2 | 0.008294 | 37 |
| WP | WP:WP5215 | Targeted agents in triple negative breast cancer | Targeted agents in triple negative breast cancer | 2 | 0.009252 | 37 |
| WP | WP:WP4566 | Translation inhibitors in chronically activated PDGFRA cells | Translation inhibitors in chronically activated PDGFRA cells | 2 | 0.013605 | 37 |
| WP | WP:WP4539 | Synaptic signaling associated with autism spectrum disorder | Synaptic signaling associated with autism spectrum disorder | 2 | 0.016092 | 37 |
| WP | WP:WP585 | Interferon type I signaling | Interferon type I signaling | 2 | 0.018787 | 37 |
| WP | WP:WP1403 | AMP activated protein kinase signaling | AMP activated protein kinase signaling | 2 | 0.028970 | 37 |
| WP | WP:WP5293 | Acute myeloid leukemia | Acute myeloid leukemia | 2 | 0.029843 | 37 |
| WP | WP:WP2034 | Leptin signaling | Leptin signaling | 2 | 0.032540 | 37 |
| WP | WP:WP2037 | Prolactin signaling | Prolactin signaling | 2 | 0.035352 | 37 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 2 | 0.035352 | 37 |
| WP | WP:WP4806 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 2 | 0.045556 | 37 |
| WP | WP:WP5094 | Orexin receptor pathway | Orexin receptor pathway | 2 | 0.049995 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 3 | 0.000104 | 37 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 3 | 0.000851 | 37 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 3 | 0.000851 | 37 |
| REAC | REAC:R-HSA-166208 | mTORC1-mediated signalling | mTORC1-mediated signalling | 2 | 0.004624 | 37 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 3 | 0.012294 | 37 |
| REAC | REAC:R-HSA-165159 | MTOR signalling | MTOR signalling | 2 | 0.013710 | 37 |
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 2 | 0.022140 | 37 |
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 2 | 0.028544 | 37 |
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 2 | 0.028544 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:4392 | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) | 2 | 0.000295 | 37 |
| CORUM | CORUM:742 | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) | 2 | 0.001947 | 37 |
| CORUM | CORUM:1097 | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) | 2 | 0.002301 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005852 | eukaryotic translation initiation factor 3 complex | "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] | 2 | 0.000405 | 37 |
| GO:CC | GO:0033290 | eukaryotic 48S preinitiation complex | "The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC." [GOC:hjd, PMID:16510876, PMID:24319994, PMID:24499181, PMID:29735639] | 2 | 0.000459 | 37 |
| GO:CC | GO:0016282 | eukaryotic 43S preinitiation complex | "A protein complex composed of the 40S ribosomal subunit plus eIF1, eIF1A, eIF3, eIF5, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049, PMID:16510876, PMID:25742741, PMID:29735639] | 2 | 0.000516 | 37 |
| GO:CC | GO:0070993 | cytosolic translation preinitiation complex | "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA." [GOC:hjd, GOC:mah] | 2 | 0.000577 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05221 | Acute myeloid leukemia | Acute myeloid leukemia | 2 | 0.001625 | 37 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 2 | 0.002265 | 37 |
| KEGG | KEGG:04012 | ErbB signaling pathway | ErbB signaling pathway | 2 | 0.002563 | 37 |
| KEGG | KEGG:04211 | Longevity regulating pathway | Longevity regulating pathway | 2 | 0.002879 | 37 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | Choline metabolism in cancer | 2 | 0.003494 | 37 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | HIF-1 signaling pathway | 2 | 0.004327 | 37 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 2 | 0.005249 | 37 |
| KEGG | KEGG:04910 | Insulin signaling pathway | Insulin signaling pathway | 2 | 0.006849 | 37 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 2 | 0.008774 | 37 |
| KEGG | KEGG:04150 | mTOR signaling pathway | mTOR signaling pathway | 2 | 0.008774 | 37 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | Chemical carcinogenesis - receptor activation | 2 | 0.016288 | 37 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 2 | 0.018198 | 37 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 2 | 0.039909 | 37 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 2 | 0.046455 | 37 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003713 | transcription coactivator activity | "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 3 | 0.000647 | 38 |
| GO:MF | GO:0003712 | transcription coregulator activity | "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] | 3 | 0.004758 | 38 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 3 | 0.044579 | 38 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00231_1 | Factor: MEF-2A; motif: NNNNNNKCTAWAAATAGMNNNN; match class: 1 | Factor: MEF-2A; motif: NNNNNNKCTAWAAATAGMNNNN; match class: 1 | 2 | 0.009405 | 38 |
| TF | TF:M00026_1 | Factor: RSRFC4; motif: RNKCTATTTWTAGMWN; match class: 1 | Factor: RSRFC4; motif: RNKCTATTTWTAGMWN; match class: 1 | 2 | 0.029729 | 38 |
| TF | TF:M12042_1 | Factor: TEF-1; motif: NRCATWCCN; match class: 1 | Factor: TEF-1; motif: NRCATWCCN; match class: 1 | 3 | 0.040767 | 38 |
| TF | TF:M00407_1 | Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN; match class: 1 | Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN; match class: 1 | 2 | 0.042031 | 38 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 2 | 0.010812 | 38 |
| GO:BP | GO:0051145 | smooth muscle cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai] | 2 | 0.014087 | 38 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 2 | 0.014087 | 38 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 2 | 0.019295 | 38 |
| GO:BP | GO:0061614 | miRNA transcription | "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] | 2 | 0.019809 | 38 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 2 | 0.027103 | 38 |
| GO:BP | GO:0010586 | miRNA metabolic process | "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] | 2 | 0.037641 | 38 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6451 | MAK-ACTR-AR complex | MAK-ACTR-AR complex | 1 | 0.049932 | 38 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 4 | 2.048983e-08 | 39 |
| REAC | REAC:R-HSA-390466 | Chaperonin-mediated protein folding | Chaperonin-mediated protein folding | 4 | 7.418892e-07 | 39 |
| REAC | REAC:R-HSA-391251 | Protein folding | Protein folding | 4 | 9.617826e-07 | 39 |
| REAC | REAC:R-HSA-8964315 | G beta:gamma signalling through BTK | G beta:gamma signalling through BTK | 3 | 2.489268e-06 | 39 |
| REAC | REAC:R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | Prostacyclin signalling through prostacyclin receptor | 3 | 2.955804e-06 | 39 |
| REAC | REAC:R-HSA-418217 | G beta:gamma signalling through PLC beta | G beta:gamma signalling through PLC beta | 3 | 3.477180e-06 | 39 |
| REAC | REAC:R-HSA-8964616 | G beta:gamma signalling through CDC42 | G beta:gamma signalling through CDC42 | 3 | 3.477180e-06 | 39 |
| REAC | REAC:R-HSA-500657 | Presynaptic function of Kainate receptors | Presynaptic function of Kainate receptors | 3 | 4.056433e-06 | 39 |
| REAC | REAC:R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | ADP signalling through P2Y purinoceptor 12 | 3 | 4.696601e-06 | 39 |
| REAC | REAC:R-HSA-428930 | Thromboxane signalling through TP receptor | Thromboxane signalling through TP receptor | 3 | 6.171833e-06 | 39 |
| REAC | REAC:R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | ADP signalling through P2Y purinoceptor 1 | 3 | 6.171833e-06 | 39 |
| REAC | REAC:R-HSA-202040 | G-protein activation | G-protein activation | 3 | 6.171833e-06 | 39 |
| REAC | REAC:R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | G beta:gamma signalling through PI3Kgamma | 3 | 7.012968e-06 | 39 |
| REAC | REAC:R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | Adrenaline,noradrenaline inhibits insulin secretion | 3 | 9.986860e-06 | 39 |
| REAC | REAC:R-HSA-1296059 | G protein gated Potassium channels | G protein gated Potassium channels | 3 | 1.113843e-05 | 39 |
| REAC | REAC:R-HSA-1296041 | Activation of G protein gated Potassium channels | Activation of G protein gated Potassium channels | 3 | 1.113843e-05 | 39 |
| REAC | REAC:R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 3 | 1.113843e-05 | 39 |
| REAC | REAC:R-HSA-451326 | Activation of kainate receptors upon glutamate binding | Activation of kainate receptors upon glutamate binding | 3 | 1.237519e-05 | 39 |
| REAC | REAC:R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | Thrombin signalling through proteinase activated receptors (PARs) | 3 | 1.370016e-05 | 39 |
| REAC | REAC:R-HSA-392518 | Signal amplification | Signal amplification | 3 | 1.511639e-05 | 39 |
| REAC | REAC:R-HSA-397795 | G-protein beta:gamma signalling | G-protein beta:gamma signalling | 3 | 1.511639e-05 | 39 |
| REAC | REAC:R-HSA-163359 | Glucagon signaling in metabolic regulation | Glucagon signaling in metabolic regulation | 3 | 1.662689e-05 | 39 |
| REAC | REAC:R-HSA-420092 | Glucagon-type ligand receptors | Glucagon-type ligand receptors | 3 | 1.662689e-05 | 39 |
| REAC | REAC:R-HSA-1296065 | Inwardly rectifying K+ channels | Inwardly rectifying K+ channels | 3 | 1.994284e-05 | 39 |
| REAC | REAC:R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3 | 3.496323e-05 | 39 |
| REAC | REAC:R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | ADORA2B mediated anti-inflammatory cytokines production | 3 | 3.496323e-05 | 39 |
| REAC | REAC:R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | Vasopressin regulates renal water homeostasis via Aquaporins | 3 | 3.758290e-05 | 39 |
| REAC | REAC:R-HSA-991365 | Activation of GABAB receptors | Activation of GABAB receptors | 3 | 3.758290e-05 | 39 |
| REAC | REAC:R-HSA-977444 | GABA B receptor activation | GABA B receptor activation | 3 | 3.758290e-05 | 39 |
| REAC | REAC:R-HSA-9634597 | GPER1 signaling | GPER1 signaling | 3 | 4.033011e-05 | 39 |
| REAC | REAC:R-HSA-418597 | G alpha (z) signalling events | G alpha (z) signalling events | 3 | 5.265470e-05 | 39 |
| REAC | REAC:R-HSA-445717 | Aquaporin-mediated transport | Aquaporin-mediated transport | 3 | 6.726125e-05 | 39 |
| REAC | REAC:R-HSA-4086398 | Ca2+ pathway | Ca2+ pathway | 3 | 9.889362e-05 | 39 |
| REAC | REAC:R-HSA-977443 | GABA receptor activation | GABA receptor activation | 3 | 1.040914e-04 | 39 |
| REAC | REAC:R-HSA-9009391 | Extra-nuclear estrogen signaling | Extra-nuclear estrogen signaling | 3 | 1.812657e-04 | 39 |
| REAC | REAC:R-HSA-422356 | Regulation of insulin secretion | Regulation of insulin secretion | 3 | 2.311252e-04 | 39 |
| REAC | REAC:R-HSA-416482 | G alpha (12/13) signalling events | G alpha (12/13) signalling events | 3 | 2.495747e-04 | 39 |
| REAC | REAC:R-HSA-418346 | Platelet homeostasis | Platelet homeostasis | 3 | 2.999275e-04 | 39 |
| REAC | REAC:R-HSA-111885 | Opioid Signalling | Opioid Signalling | 3 | 3.331586e-04 | 39 |
| REAC | REAC:R-HSA-373080 | Class B/2 (Secretin family receptors) | Class B/2 (Secretin family receptors) | 3 | 3.938346e-04 | 39 |
| REAC | REAC:R-HSA-1296071 | Potassium Channels | Potassium Channels | 3 | 5.363675e-04 | 39 |
| REAC | REAC:R-HSA-163685 | Integration of energy metabolism | Integration of energy metabolism | 3 | 6.018155e-04 | 39 |
| REAC | REAC:R-HSA-9664433 | Leishmania parasite growth and survival | Leishmania parasite growth and survival | 3 | 1.108339e-03 | 39 |
| REAC | REAC:R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | Anti-inflammatory response favouring Leishmania parasite infection | 3 | 1.108339e-03 | 39 |
| REAC | REAC:R-HSA-3858494 | Beta-catenin independent WNT signaling | Beta-catenin independent WNT signaling | 3 | 1.443288e-03 | 39 |
| REAC | REAC:R-HSA-418555 | G alpha (s) signalling events | G alpha (s) signalling events | 3 | 1.875417e-03 | 39 |
| REAC | REAC:R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | Neurotransmitter receptors and postsynaptic signal transmission | 3 | 3.667296e-03 | 39 |
| REAC | REAC:R-HSA-416476 | G alpha (q) signalling events | G alpha (q) signalling events | 3 | 4.712807e-03 | 39 |
| REAC | REAC:R-HSA-9824443 | Parasitic Infection Pathways | Parasitic Infection Pathways | 3 | 4.847426e-03 | 39 |
| REAC | REAC:R-HSA-9658195 | Leishmania infection | Leishmania infection | 3 | 4.847426e-03 | 39 |
| REAC | REAC:R-HSA-8939211 | ESR-mediated signaling | ESR-mediated signaling | 3 | 4.915681e-03 | 39 |
| REAC | REAC:R-HSA-112315 | Transmission across Chemical Synapses | Transmission across Chemical Synapses | 3 | 8.488890e-03 | 39 |
| REAC | REAC:R-HSA-76002 | Platelet activation, signaling and aggregation | Platelet activation, signaling and aggregation | 3 | 8.587774e-03 | 39 |
| REAC | REAC:R-HSA-9006931 | Signaling by Nuclear Receptors | Signaling by Nuclear Receptors | 3 | 1.192052e-02 | 39 |
| REAC | REAC:R-HSA-418594 | G alpha (i) signalling events | G alpha (i) signalling events | 3 | 1.484358e-02 | 39 |
| REAC | REAC:R-HSA-195721 | Signaling by WNT | Signaling by WNT | 3 | 1.724339e-02 | 39 |
| REAC | REAC:R-HSA-112316 | Neuronal System | Neuronal System | 3 | 3.122015e-02 | 39 |
| REAC | REAC:R-HSA-500792 | GPCR ligand binding | GPCR ligand binding | 3 | 4.768309e-02 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005834 | heterotrimeric G-protein complex | "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684] | 3 | 0.000002 | 39 |
| GO:CC | GO:1905360 | GTPase complex | "A protein complex which is capable of GTPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9178006] | 3 | 0.000003 | 39 |
| GO:CC | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane | "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] | 3 | 0.000007 | 39 |
| GO:CC | GO:0019897 | extrinsic component of plasma membrane | "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] | 3 | 0.000071 | 39 |
| GO:CC | GO:0009898 | cytoplasmic side of plasma membrane | "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] | 3 | 0.000223 | 39 |
| GO:CC | GO:0019898 | extrinsic component of membrane | "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] | 3 | 0.000341 | 39 |
| GO:CC | GO:0098562 | cytoplasmic side of membrane | "The side of a membrane that faces the cytoplasm." [GOC:dos] | 3 | 0.000461 | 39 |
| GO:CC | GO:0098797 | plasma membrane protein complex | "Any protein complex that is part of the plasma membrane." [GOC:dos] | 3 | 0.018827 | 39 |
| GO:CC | GO:0098552 | side of membrane | "A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface." [GOC:dos] | 3 | 0.020498 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04727 | GABAergic synapse | GABAergic synapse | 3 | 0.000055 | 39 |
| KEGG | KEGG:05032 | Morphine addiction | Morphine addiction | 3 | 0.000055 | 39 |
| KEGG | KEGG:04713 | Circadian entrainment | Circadian entrainment | 3 | 0.000072 | 39 |
| KEGG | KEGG:04726 | Serotonergic synapse | Serotonergic synapse | 3 | 0.000111 | 39 |
| KEGG | KEGG:04725 | Cholinergic synapse | Cholinergic synapse | 3 | 0.000114 | 39 |
| KEGG | KEGG:04724 | Glutamatergic synapse | Glutamatergic synapse | 3 | 0.000120 | 39 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | Relaxin signaling pathway | 3 | 0.000170 | 39 |
| KEGG | KEGG:04728 | Dopaminergic synapse | Dopaminergic synapse | 3 | 0.000178 | 39 |
| KEGG | KEGG:04371 | Apelin signaling pathway | Apelin signaling pathway | 3 | 0.000209 | 39 |
| KEGG | KEGG:04723 | Retrograde endocannabinoid signaling | Retrograde endocannabinoid signaling | 3 | 0.000258 | 39 |
| KEGG | KEGG:05034 | Alcoholism | Alcoholism | 3 | 0.000522 | 39 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | Chemokine signaling pathway | 3 | 0.000547 | 39 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 3 | 0.000583 | 39 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | Human immunodeficiency virus 1 infection | 3 | 0.000740 | 39 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 3 | 0.000887 | 39 |
| KEGG | KEGG:04014 | Ras signaling pathway | Ras signaling pathway | 3 | 0.001039 | 39 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 3 | 0.003628 | 39 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 3 | 0.011802 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP35 | G protein signaling | G protein signaling | 3 | 0.000066 | 39 |
| WP | WP:WP536 | Calcium regulation in cardiac cells | Calcium regulation in cardiac cells | 3 | 0.000322 | 39 |
| WP | WP:WP289 | Myometrial relaxation and contraction pathways | Myometrial relaxation and contraction pathways | 3 | 0.000349 | 39 |
| WP | WP:WP3929 | Chemokine signaling | Chemokine signaling | 3 | 0.000430 | 39 |
| WP | WP:WP4223 | Ras signaling | Ras signaling | 3 | 0.000587 | 39 |
| WP | WP:WP3932 | Focal adhesion PI3K Akt mTOR signaling | Focal adhesion PI3K Akt mTOR signaling | 3 | 0.002656 | 39 |
| WP | WP:WP4172 | PI3K Akt signaling | PI3K Akt signaling | 3 | 0.003662 | 39 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 3 | 0.012470 | 39 |
| WP | WP:WP2355 | Corticotropin releasing hormone signaling | Corticotropin releasing hormone signaling | 2 | 0.020798 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7205 | GNAS-L-GNB2-GNG12 complex | GNAS-L-GNB2-GNG12 complex | 2 | 0.000132 | 39 |
| CORUM | CORUM:7087 | GNAI1-GNB2-GNG12 complex | GNAI1-GNB2-GNG12 complex | 2 | 0.000132 | 39 |
| CORUM | CORUM:7204 | GNAS-L-GNB1-GNG12 complex | GNAS-L-GNB1-GNG12 complex | 2 | 0.000132 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0030159 | signaling receptor complex adaptor activity | "The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah] | 2 | 0.009028 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007186 | G protein-coupled receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] | 4 | 0.009375 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0210863 | Fallopian tube; ciliated cells (cilia axoneme)[High] | Fallopian tube; ciliated cells (cilia axoneme)[High] | 2 | 0.040154 | 39 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005782 | peroxisomal matrix | "The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:curators, ISBN:0815316194] | 4 | 3.443024e-09 | 40 |
| GO:CC | GO:0031907 | microbody lumen | "The volume enclosed by the membranes of a microbody." [GOC:mah] | 4 | 3.443024e-09 | 40 |
| GO:CC | GO:0005777 | peroxisome | "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] | 4 | 2.502545e-07 | 40 |
| GO:CC | GO:0042579 | microbody | "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732] | 4 | 2.502545e-07 | 40 |
| GO:CC | GO:0005778 | peroxisomal membrane | "The lipid bilayer surrounding a peroxisome." [GOC:mah] | 3 | 1.458504e-05 | 40 |
| GO:CC | GO:0031903 | microbody membrane | "The lipid bilayer surrounding a microbody." [GOC:mah] | 3 | 1.458504e-05 | 40 |
| GO:CC | GO:0062151 | catalase complex | "A protein-containing complex that is capable of catalase activity." [GOC:bhm, PMID:10656833] | 1 | 2.494407e-02 | 40 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04146 | Peroxisome | Peroxisome | 4 | 4.575008e-07 | 40 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9033241 | Peroxisomal protein import | Peroxisomal protein import | 3 | 0.000104 | 40 |
| REAC | REAC:R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | TYSND1 cleaves peroxisomal proteins | 2 | 0.000353 | 40 |
| REAC | REAC:R-HSA-9609507 | Protein localization | Protein localization | 3 | 0.001986 | 40 |
| REAC | REAC:R-HSA-390918 | Peroxisomal lipid metabolism | Peroxisomal lipid metabolism | 2 | 0.004624 | 40 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0009062 | fatty acid catabolic process | "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators] | 3 | 0.000340 | 40 |
| GO:BP | GO:0019395 | fatty acid oxidation | "The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732] | 3 | 0.000370 | 40 |
| GO:BP | GO:0034440 | lipid oxidation | "The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GOC:BHF, GOC:mah] | 3 | 0.000435 | 40 |
| GO:BP | GO:0072329 | monocarboxylic acid catabolic process | "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah] | 3 | 0.000558 | 40 |
| GO:BP | GO:0030258 | lipid modification | "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah] | 3 | 0.002113 | 40 |
| GO:BP | GO:0016054 | organic acid catabolic process | "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] | 3 | 0.004183 | 40 |
| GO:BP | GO:0046395 | carboxylic acid catabolic process | "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] | 3 | 0.004183 | 40 |
| GO:BP | GO:0000038 | very long-chain fatty acid metabolic process | "The chemical reactions and pathways involving a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [GOC:hjd] | 2 | 0.010745 | 40 |
| GO:BP | GO:0016042 | lipid catabolic process | "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] | 3 | 0.012463 | 40 |
| GO:BP | GO:0006629 | lipid metabolic process | "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] | 4 | 0.012719 | 40 |
| GO:BP | GO:0044282 | small molecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw] | 3 | 0.014342 | 40 |
| GO:BP | GO:0006631 | fatty acid metabolic process | "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] | 3 | 0.017967 | 40 |
| GO:BP | GO:0044281 | small molecule metabolic process | "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] | 4 | 0.033831 | 40 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002832 | Calcific stippling | An abnormal punctate (speckled, dot-like) pattern of calcifications in soft tissues within or surrounding bones (as observed on radiographs). | 2 | 0.004006 | 40 |
| HP | HP:0004359 | Abnormal circulating fatty-acid concentration | A deviation from the normal concentration of a fatty acid in the blood circulation. | 3 | 0.010982 | 40 |
| HP | HP:0010965 | Abnormal circulating phytanic acid concentration | Any deviation from the normal concentration of phytanic acid in the blood circulation. | 2 | 0.047936 | 40 |
| HP | HP:0010571 | Elevated circulating phytanic acid concentration | An abnormal elevation of phytanic acid. | 2 | 0.047936 | 40 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0048244 | phytanoyl-CoA dioxygenase activity | "Catalysis of the reaction: 2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate." [EC:1.14.11.18, RHEA:16065] | 1 | 0.049891 | 40 |
| GO:MF | GO:0033989 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity | "Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O." [EC:4.2.1.107] | 1 | 0.049891 | 40 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04916 | Melanogenesis | Melanogenesis | 3 | 0.000349 | 41 |
| KEGG | KEGG:04962 | Vasopressin-regulated water reabsorption | Vasopressin-regulated water reabsorption | 2 | 0.008415 | 41 |
| KEGG | KEGG:05030 | Cocaine addiction | Cocaine addiction | 2 | 0.010453 | 41 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | Cortisol synthesis and secretion | 2 | 0.017877 | 41 |
| KEGG | KEGG:05031 | Amphetamine addiction | Amphetamine addiction | 2 | 0.020787 | 41 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | Thyroid hormone synthesis | 2 | 0.024565 | 41 |
| KEGG | KEGG:04911 | Insulin secretion | Insulin secretion | 2 | 0.031553 | 41 |
| KEGG | KEGG:04211 | Longevity regulating pathway | Longevity regulating pathway | 2 | 0.034589 | 41 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 2 | 0.041073 | 41 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | Aldosterone synthesis and secretion | 2 | 0.041922 | 41 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | Parathyroid hormone synthesis, secretion and action | 2 | 0.048105 | 41 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | Glucagon signaling pathway | 2 | 0.049948 | 41 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-3232118 | SUMOylation of transcription factors | SUMOylation of transcription factors | 2 | 0.001387 | 41 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 4 | 0.001977 | 41 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 4 | 0.002274 | 41 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 4 | 0.015524 | 41 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 4 | 0.017481 | 41 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 4 | 0.028197 | 41 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 4 | 0.028330 | 41 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 4 | 0.038559 | 41 |
| GO:BP | GO:0045670 | regulation of osteoclast differentiation | "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] | 2 | 0.046050 | 41 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 4 | 0.046512 | 41 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 4 | 0.002221 | 41 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 4 | 0.009176 | 41 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5272 | LDL influence on CD14 and TLR4 | LDL influence on CD14 and TLR4 | 2 | 0.003337 | 41 |
| WP | WP:WP4941 | GPR143 in melanocytes and retinal pigment epithelium cells | GPR143 in melanocytes and retinal pigment epithelium cells | 2 | 0.005732 | 41 |
| WP | WP:WP5085 | Vasopressin regulated water reabsorption | Vasopressin regulated water reabsorption | 2 | 0.012439 | 41 |
| WP | WP:WP4756 | Renin angiotensin aldosterone system RAAS | Renin angiotensin aldosterone system RAAS | 2 | 0.012439 | 41 |
| WP | WP:WP2332 | IL11 signaling | IL11 signaling | 2 | 0.012439 | 41 |
| WP | WP:WP585 | Interferon type I signaling | Interferon type I signaling | 2 | 0.018787 | 41 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 2 | 0.026427 | 41 |
| WP | WP:WP4685 | Melanoma | Melanoma | 2 | 0.029843 | 41 |
| WP | WP:WP138 | Androgen receptor signaling | Androgen receptor signaling | 2 | 0.046647 | 41 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0000976 | transcription cis-regulatory region binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] | 4 | 0.007282 | 41 |
| GO:MF | GO:0001067 | transcription regulatory region nucleic acid binding | "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] | 4 | 0.007301 | 41 |
| GO:MF | GO:1990837 | sequence-specific double-stranded DNA binding | "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] | 4 | 0.008577 | 41 |
| GO:MF | GO:0003690 | double-stranded DNA binding | "Binding to double-stranded DNA." [GOC:elh, GOC:vw] | 4 | 0.010942 | 41 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 4 | 0.011293 | 41 |
| GO:MF | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] | 3 | 0.013061 | 41 |
| GO:MF | GO:0001216 | DNA-binding transcription activator activity | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] | 3 | 0.013639 | 41 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 3 | 0.013808 | 41 |
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 4 | 0.021849 | 41 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 3 | 0.025458 | 41 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 3 | 0.043826 | 41 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0052720 | class II DNA-(apurinic or apyrimidinic site) endonuclease activity | "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends." [PMID:1698278] | 1 | 0.049891 | 43 |
| GO:MF | GO:0090580 | phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands | "Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand." [GOC:pde, GOC:rb, PMID:11238902] | 1 | 0.049891 | 43 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043112 | receptor metabolic process | "The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:jl] | 2 | 0.047344 | 44 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0034750 | Scrib-APC-beta-catenin complex | "A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation." [PMID:16611247] | 1 | 0.049885 | 44 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 2 | 0.049925 | 44 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032222 | Serrated intestinal polyps | The presence of multiple serrated polyps in the intestine. Unlike conventional adenomas, which are uniformly dysplastic, the vast majority of serrated lesions contain no dysplasia. The serrated class includes the hyperplastic polyps, which are not considered precancerous; sessile serrated polyps (also called sessile serrated adenomas); and traditional serrated adenomas. Sessile serrated polyps are larger on average and more often located in the proximal colon. Sessile serrated polyps have a more irregular surface, a pattern to the surface that has been called cloudlike, and indistinct edges compared with hyperplastic polyps. Sessile serrated polyps also have large open pits on the surface (type O pits) when viewed with magnification. | 1 | 0.049962 | 44 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:933 | SCRIB-APC complex | SCRIB-APC complex | 1 | 0.049988 | 44 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030126 | COPI vesicle coat | "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894] | 3 | 8.723446e-08 | 45 |
| GO:CC | GO:0030663 | COPI-coated vesicle membrane | "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah] | 3 | 2.488506e-07 | 45 |
| GO:CC | GO:0030137 | COPI-coated vesicle | "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894] | 3 | 7.012506e-07 | 45 |
| GO:CC | GO:0030660 | Golgi-associated vesicle membrane | "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] | 3 | 9.397213e-06 | 45 |
| GO:CC | GO:0030120 | vesicle coat | "A membrane coat found on a coated vesicle." [GOC:mah] | 3 | 1.209196e-05 | 45 |
| GO:CC | GO:0005798 | Golgi-associated vesicle | "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] | 3 | 4.345808e-05 | 45 |
| GO:CC | GO:0030117 | membrane coat | "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] | 3 | 4.770200e-05 | 45 |
| GO:CC | GO:0048475 | coated membrane | "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid] | 3 | 4.770200e-05 | 45 |
| GO:CC | GO:0030662 | coated vesicle membrane | "The lipid bilayer surrounding a coated vesicle." [GOC:mah] | 3 | 3.980696e-04 | 45 |
| GO:CC | GO:0030135 | coated vesicle | "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] | 3 | 1.602631e-03 | 45 |
| GO:CC | GO:0030133 | transport vesicle | "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] | 3 | 4.624466e-03 | 45 |
| GO:CC | GO:0000139 | Golgi membrane | "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] | 3 | 1.610622e-02 | 45 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | COPI-dependent Golgi-to-ER retrograde traffic | 3 | 0.000129 | 45 |
| REAC | REAC:R-HSA-6807878 | COPI-mediated anterograde transport | COPI-mediated anterograde transport | 3 | 0.000142 | 45 |
| REAC | REAC:R-HSA-8856688 | Golgi-to-ER retrograde transport | Golgi-to-ER retrograde transport | 3 | 0.000316 | 45 |
| REAC | REAC:R-HSA-199977 | ER to Golgi Anterograde Transport | ER to Golgi Anterograde Transport | 3 | 0.000502 | 45 |
| REAC | REAC:R-HSA-948021 | Transport to the Golgi and subsequent modification | Transport to the Golgi and subsequent modification | 3 | 0.000871 | 45 |
| REAC | REAC:R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | Intra-Golgi and retrograde Golgi-to-ER traffic | 3 | 0.001116 | 45 |
| REAC | REAC:R-HSA-446203 | Asparagine N-linked glycosylation | Asparagine N-linked glycosylation | 3 | 0.003863 | 45 |
| REAC | REAC:R-HSA-199991 | Membrane Trafficking | Membrane Trafficking | 3 | 0.033406 | 45 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] | 3 | 0.000703 | 45 |
| GO:BP | GO:0051645 | Golgi localization | "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] | 2 | 0.001646 | 45 |
| GO:BP | GO:0048193 | Golgi vesicle transport | "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] | 3 | 0.008535 | 45 |
| GO:BP | GO:0006891 | intra-Golgi vesicle-mediated transport | "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363] | 2 | 0.010745 | 45 |
| GO:BP | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524] | 2 | 0.025811 | 45 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3596 | miR 517 relationship with ARCN1 and USP1 | miR 517 relationship with ARCN1 and USP1 | 1 | 0.049667 | 45 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1904780 | negative regulation of protein localization to centrosome | "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] | 2 | 0.000018 | 46 |
| GO:BP | GO:0046604 | positive regulation of mitotic centrosome separation | "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai] | 2 | 0.000054 | 46 |
| GO:BP | GO:0046602 | regulation of mitotic centrosome separation | "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai] | 2 | 0.000651 | 46 |
| GO:BP | GO:0007030 | Golgi organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] | 3 | 0.001002 | 46 |
| GO:BP | GO:1904779 | regulation of protein localization to centrosome | "Any process that modulates the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] | 2 | 0.001194 | 46 |
| GO:BP | GO:0007100 | mitotic centrosome separation | "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194] | 2 | 0.001646 | 46 |
| GO:BP | GO:0061025 | membrane fusion | "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb] | 3 | 0.001894 | 46 |
| GO:BP | GO:0051299 | centrosome separation | "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] | 2 | 0.002170 | 46 |
| GO:BP | GO:0031468 | nuclear membrane reassembly | "The reformation of the nuclear membranes following their breakdown in the context of a normal process." [GOC:mah] | 2 | 0.006342 | 46 |
| GO:BP | GO:0071539 | protein localization to centrosome | "A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd] | 2 | 0.012026 | 46 |
| GO:BP | GO:0000132 | establishment of mitotic spindle orientation | "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] | 2 | 0.012026 | 46 |
| GO:BP | GO:1905508 | protein localization to microtubule organizing center | "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497] | 2 | 0.012693 | 46 |
| GO:BP | GO:0016236 | macroautophagy | "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339] | 3 | 0.013325 | 46 |
| GO:BP | GO:0040001 | establishment of mitotic spindle localization | "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai] | 2 | 0.016299 | 46 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 4 | 0.016570 | 46 |
| GO:BP | GO:0051294 | establishment of spindle orientation | "Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai] | 2 | 0.019507 | 46 |
| GO:BP | GO:0071763 | nuclear membrane organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah] | 2 | 0.020353 | 46 |
| GO:BP | GO:0072698 | protein localization to microtubule cytoskeleton | "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah] | 2 | 0.029808 | 46 |
| GO:BP | GO:0006998 | nuclear envelope organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] | 2 | 0.030851 | 46 |
| GO:BP | GO:0071709 | membrane assembly | "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah] | 2 | 0.032993 | 46 |
| GO:BP | GO:0044380 | protein localization to cytoskeleton | "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl] | 2 | 0.034091 | 46 |
| GO:BP | GO:0051293 | establishment of spindle localization | "The directed movement of the spindle to a specific location in the cell." [GOC:ai] | 2 | 0.035206 | 46 |
| GO:BP | GO:0044091 | membrane biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl] | 2 | 0.039847 | 46 |
| GO:BP | GO:0051653 | spindle localization | "Any process in which is the spindle is transported to, and/or maintained in, a specific location." [GOC:ai] | 2 | 0.041052 | 46 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 3 | 0.044803 | 46 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5202 | Alstrom syndrome | Alstrom syndrome | 2 | 0.002531 | 46 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 2 | 0.010313 | 46 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 3 | 0.020498 | 46 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 3 | 0.034195 | 46 |
| GO:CC | GO:0005795 | Golgi stack | "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] | 2 | 0.037422 | 46 |
| GO:CC | GO:1990730 | VCP-NSFL1C complex | "A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97." [GOC:bf, GOC:PARL, PMID:9214505] | 1 | 0.049885 | 46 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0043130 | ubiquitin binding | "Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd] | 2 | 0.03636 | 46 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 4 | 6.046900e-07 | 47 |
| WP | WP:WP3981 | miRNA regulation of prostate cancer signaling | miRNA regulation of prostate cancer signaling | 3 | 1.356352e-05 | 47 |
| WP | WP:WP5497 | Cyclin dependent kinase 4 6 inhibitors in breast cancer | Cyclin dependent kinase 4 6 inhibitors in breast cancer | 3 | 2.544006e-05 | 47 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 3 | 1.138167e-04 | 47 |
| WP | WP:WP4172 | PI3K Akt signaling | PI3K Akt signaling | 4 | 1.803398e-04 | 47 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 3 | 1.948817e-04 | 47 |
| WP | WP:WP673 | ErbB signaling | ErbB signaling | 3 | 3.409680e-04 | 47 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 3 | 4.153660e-04 | 47 |
| WP | WP:WP5475 | Hallmark of cancer sustaining proliferative signaling | Hallmark of cancer sustaining proliferative signaling | 3 | 4.563027e-04 | 47 |
| WP | WP:WP710 | DNA damage response only ATM dependent | DNA damage response only ATM dependent | 3 | 6.292235e-04 | 47 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 3 | 7.015199e-04 | 47 |
| WP | WP:WP5494 | Tyrosine kinase inhibitors in glioblastoma | Tyrosine kinase inhibitors in glioblastoma | 2 | 4.285074e-03 | 47 |
| WP | WP:WP3844 | PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer | PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer | 2 | 6.533694e-03 | 47 |
| WP | WP:WP5490 | Inhibition of GNAQ regulated signaling in uveal melanoma | Inhibition of GNAQ regulated signaling in uveal melanoma | 2 | 6.954161e-03 | 47 |
| WP | WP:WP5531 | AKT signaling and ARTD family members | AKT signaling and ARTD family members | 2 | 7.387668e-03 | 47 |
| WP | WP:WP5215 | Targeted agents in triple negative breast cancer | Targeted agents in triple negative breast cancer | 2 | 9.251976e-03 | 47 |
| WP | WP:WP34 | Ovarian infertility | Ovarian infertility | 2 | 9.750593e-03 | 47 |
| WP | WP:WP5300 | TROP2 regulatory signaling | TROP2 regulatory signaling | 2 | 1.243862e-02 | 47 |
| WP | WP:WP3932 | Focal adhesion PI3K Akt mTOR signaling | Focal adhesion PI3K Akt mTOR signaling | 3 | 1.339532e-02 | 47 |
| WP | WP:WP363 | Wnt signaling NetPath | Wnt signaling NetPath | 2 | 1.420717e-02 | 47 |
| WP | WP:WP4539 | Synaptic signaling associated with autism spectrum disorder | Synaptic signaling associated with autism spectrum disorder | 2 | 1.609233e-02 | 47 |
| WP | WP:WP5144 | NRP1 triggered signaling in pancreatic cancer | NRP1 triggered signaling in pancreatic cancer | 2 | 1.809393e-02 | 47 |
| WP | WP:WP4155 | Endometrial cancer | Endometrial cancer | 2 | 2.560481e-02 | 47 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 2 | 2.642673e-02 | 47 |
| WP | WP:WP5293 | Acute myeloid leukemia | Acute myeloid leukemia | 2 | 2.984288e-02 | 47 |
| WP | WP:WP4685 | Melanoma | Melanoma | 2 | 2.984288e-02 | 47 |
| WP | WP:WP1545 | miRNAs involved in DNA damage response | miRNAs involved in DNA damage response | 2 | 2.984288e-02 | 47 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 2 | 3.072901e-02 | 47 |
| WP | WP:WP4255 | Non small cell lung cancer | Non small cell lung cancer | 2 | 3.346431e-02 | 47 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 2 | 3.440170e-02 | 47 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 2 | 3.440170e-02 | 47 |
| WP | WP:WP5087 | Pleural mesothelioma | Pleural mesothelioma | 3 | 3.968383e-02 | 47 |
| WP | WP:WP4806 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 2 | 4.555649e-02 | 47 |
| WP | WP:WP2571 | Polycystic kidney disease pathway | Polycystic kidney disease pathway | 2 | 4.555649e-02 | 47 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 2 | 4.999523e-02 | 47 |
| WP | WP:WP5098 | T cell activation SARS CoV 2 | T cell activation SARS CoV 2 | 2 | 4.999523e-02 | 47 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-198323 | AKT phosphorylates targets in the cytosol | AKT phosphorylates targets in the cytosol | 3 | 0.000001 | 47 |
| REAC | REAC:R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3 | 0.000005 | 47 |
| REAC | REAC:R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | Constitutive Signaling by AKT1 E17K in Cancer | 3 | 0.000007 | 47 |
| REAC | REAC:R-HSA-9009391 | Extra-nuclear estrogen signaling | Extra-nuclear estrogen signaling | 3 | 0.000181 | 47 |
| REAC | REAC:R-HSA-8849470 | PTK6 Regulates Cell Cycle | PTK6 Regulates Cell Cycle | 2 | 0.000252 | 47 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 3 | 0.000269 | 47 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 3 | 0.000289 | 47 |
| REAC | REAC:R-HSA-2219528 | PI3K/AKT Signaling in Cancer | PI3K/AKT Signaling in Cancer | 3 | 0.000369 | 47 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 3 | 0.001108 | 47 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 3 | 0.001601 | 47 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 3 | 0.002101 | 47 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2 | 0.002280 | 47 |
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2 | 0.002280 | 47 |
| REAC | REAC:R-HSA-8939211 | ESR-mediated signaling | ESR-mediated signaling | 3 | 0.004916 | 47 |
| REAC | REAC:R-HSA-1257604 | PIP3 activates AKT signaling | PIP3 activates AKT signaling | 3 | 0.007911 | 47 |
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2 | 0.010539 | 47 |
| REAC | REAC:R-HSA-9607240 | FLT3 Signaling | FLT3 Signaling | 2 | 0.010539 | 47 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 2 | 0.011758 | 47 |
| REAC | REAC:R-HSA-9006931 | Signaling by Nuclear Receptors | Signaling by Nuclear Receptors | 3 | 0.011921 | 47 |
| REAC | REAC:R-HSA-9006925 | Intracellular signaling by second messengers | Intracellular signaling by second messengers | 3 | 0.012294 | 47 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 2 | 0.018060 | 47 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 2 | 0.018060 | 47 |
| REAC | REAC:R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | Signaling by Non-Receptor Tyrosine Kinases | 2 | 0.021291 | 47 |
| REAC | REAC:R-HSA-8848021 | Signaling by PTK6 | Signaling by PTK6 | 2 | 0.021291 | 47 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 3 | 0.022785 | 47 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 4 | 0.026689 | 47 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 2 | 0.029525 | 47 |
| REAC | REAC:R-HSA-9614085 | FOXO-mediated transcription | FOXO-mediated transcription | 2 | 0.035754 | 47 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 4 | 0.038816 | 47 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 3 | 0.042917 | 47 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0030405 | Pancreatic endocrine tumor | A neuroendocrine tumor originating in a hormone-producing cell (islet cell) of the pancreas. | 3 | 0.000045 | 47 |
| HP | HP:0002666 | Pheochromocytoma | Pheochromocytomas (also known as chromaffin tumors) produce, store, and secrete catecholamines. Pheochromocytomas usually originate from the adrenal medulla but may also develop from chromaffin cells in or about sympathetic ganglia. A common symptom of pheochromocytoma is hypertension owing to release of catecholamines. | 3 | 0.000515 | 47 |
| HP | HP:0100634 | Neuroendocrine neoplasm | A tumor that originates from a neuroendocrine cell. | 3 | 0.001325 | 47 |
| HP | HP:0006772 | Renal angiomyolipoma | A benign renal neoplasm composed of fat, vascular, and smooth muscle elements. | 2 | 0.004006 | 47 |
| HP | HP:0010566 | Hamartoma | A disordered proliferation of mature tissues that is native to the site of origin, e.g., exostoses, nevi and soft tissue hamartomas. Although most hamartomas are benign, some histologic subtypes, e.g., neuromuscular hamartoma, may proliferate aggressively such as mesenchymal cystic hamartoma, Sclerosing epithelial hamartoma, Sclerosing metanephric hamartoma. | 3 | 0.006834 | 47 |
| HP | HP:0008696 | Renal hamartoma | A disordered proliferation of mature tissues that are native to the kidneys. | 2 | 0.008409 | 47 |
| HP | HP:0100007 | Neoplasm of the peripheral nervous system | A benign or malignant neoplasm (tumor) of the peripheral nervous system. | 3 | 0.008559 | 47 |
| HP | HP:0008261 | Pancreatic islet cell adenoma | The presence of an adenoma of the pancreas with origin in a pancreatic B cell. | 2 | 0.014407 | 47 |
| HP | HP:0007449 | Confetti-like hypopigmented macules | Confetti-like hypopigmented macules | 2 | 0.014407 | 47 |
| HP | HP:0008208 | Parathyroid hyperplasia | Hyperplasia of the parathyroid gland. | 2 | 0.018005 | 47 |
| HP | HP:0100570 | Carcinoid tumor | A tumor formed from the endocrine (argentaffin) cells of the mucosal lining of a variety of organs including the stomach and intestine. These cells are from neuroectodermal origin. | 2 | 0.026393 | 47 |
| HP | HP:0100835 | Benign neoplasm of the central nervous system | Benign neoplasm of the central nervous system | 3 | 0.028328 | 47 |
| HP | HP:0007206 | Hemimegalencephaly | Enlargement of all or parts of one cerebral hemisphere. | 2 | 0.036371 | 47 |
| HP | HP:0032046 | Focal cortical dysplasia | A type of malformation of cortical development that primarily affects areas of neocortex. It can be identified on conventional magnetic resonance imaging as focal cortical thickening, abnormal gyration, and blurring between gray and white matter, often associated with clusters of heterotopic neurons. | 2 | 0.041955 | 47 |
| HP | HP:0030448 | Soft tissue sarcoma | A type of sarcoma (A connective tissue neoplasm formed by proliferation of mesodermal cells) that develops from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues. | 3 | 0.043582 | 47 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 4 | 0.000121 | 47 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 3 | 0.000147 | 47 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 4 | 0.000164 | 47 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 3 | 0.000263 | 47 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 3 | 0.000290 | 47 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 3 | 0.000309 | 47 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | AGE-RAGE signaling pathway in diabetic complications | 3 | 0.000338 | 47 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 3 | 0.000587 | 47 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | Thyroid hormone signaling pathway | 3 | 0.000602 | 47 |
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 3 | 0.000764 | 47 |
| KEGG | KEGG:05162 | Measles | Measles | 3 | 0.000894 | 47 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 3 | 0.001103 | 47 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 3 | 0.001268 | 47 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 3 | 0.002644 | 47 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 3 | 0.003775 | 47 |
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 2 | 0.014672 | 47 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | Acute myeloid leukemia | 2 | 0.019597 | 47 |
| KEGG | KEGG:04917 | Prolactin signaling pathway | Prolactin signaling pathway | 2 | 0.021395 | 47 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 2 | 0.022637 | 47 |
| KEGG | KEGG:05218 | Melanoma | Melanoma | 2 | 0.022637 | 47 |
| KEGG | KEGG:04115 | p53 signaling pathway | p53 signaling pathway | 2 | 0.023914 | 47 |
| KEGG | KEGG:05214 | Glioma | Glioma | 2 | 0.024565 | 47 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 2 | 0.025225 | 47 |
| KEGG | KEGG:04012 | ErbB signaling pathway | ErbB signaling pathway | 2 | 0.030815 | 47 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 2 | 0.032299 | 47 |
| KEGG | KEGG:04211 | Longevity regulating pathway | Longevity regulating pathway | 2 | 0.034589 | 47 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | Choline metabolism in cancer | 2 | 0.041922 | 47 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 3 | 0.048841 | 47 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006468 | protein phosphorylation | "The process of introducing a phosphate group on to a protein." [GOC:hb] | 4 | 0.007696 | 47 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 4 | 0.010312 | 47 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] | 3 | 0.013547 | 47 |
| GO:BP | GO:0045859 | regulation of protein kinase activity | "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] | 3 | 0.018237 | 47 |
| GO:BP | GO:0043549 | regulation of kinase activity | "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] | 3 | 0.022464 | 47 |
| GO:BP | GO:0050673 | epithelial cell proliferation | "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] | 3 | 0.024059 | 47 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 4 | 0.027407 | 47 |
| GO:BP | GO:0051338 | regulation of transferase activity | "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] | 3 | 0.034601 | 47 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 4 | 0.038140 | 47 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 2 | 0.008314 | 47 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 2 | 0.019874 | 47 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 2 | 0.019874 | 47 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 3 | 0.020494 | 47 |
| GO:MF | GO:0008047 | enzyme activator activity | "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 3 | 0.026877 | 47 |
| GO:MF | GO:0019914 | cyclin-dependent protein kinase activating kinase regulator activity | "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai] | 1 | 0.049891 | 47 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097128 | cyclin D1-CDK4 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 1 | 0.049885 | 47 |
| GO:CC | GO:0097131 | cyclin D1-CDK6 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 1 | 0.049885 | 47 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1656 | p27-cyclinE-CDK2 complex | p27-cyclinE-CDK2 complex | 1 | 0.049988 | 47 |
| CORUM | CORUM:3084 | CCND1-CDK4 complex | CCND1-CDK4 complex | 1 | 0.049988 | 47 |
| CORUM | CORUM:5287 | CCND1-CDK4 complex | CCND1-CDK4 complex | 1 | 0.049988 | 47 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12893 | Factor: ZBED2; motif: NNNNCGAAACCNNN | Factor: ZBED2; motif: NNNNCGAAACCNNN | 3 | 0.039897 | 48 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008832 | dGTPase activity | "Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate." [RHEA:15193] | 1 | 0.049724 | 48 |
| GO:MF | GO:0016793 | triphosphoric monoester hydrolase activity | "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [EC:3.1.5.-] | 1 | 0.049724 | 48 |
| GO:MF | GO:0032560 | guanyl deoxyribonucleotide binding | "Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] | 1 | 0.049724 | 48 |
| GO:MF | GO:0032567 | dGTP binding | "Binding to dGTP, deoxyguanosine triphosphate." [GOC:mah] | 1 | 0.049724 | 48 |
| GO:MF | GO:0106375 | deoxynucleoside triphosphate hydrolase activity | "Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate." [RHEA:46148] | 1 | 0.049724 | 48 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:6000263 | Papillary dermal edema | Swelling due to fluid acculuation of the papillary dermis. | 1 | 0.049962 | 48 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 3 | 0.019640 | 49 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 3 | 0.031240 | 49 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 3 | 0.040697 | 49 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0043795 | glyceraldehyde oxidoreductase activity | "Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H+." [PMID:10095793, RHEA:36047] | 1 | 0.049724 | 49 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2000331 | regulation of terminal button organization | "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] | 1 | 0.049542 | 50 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00310 | Lysine degradation | Lysine degradation | 2 | 0.008022 | 52 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004753 | saccharopine dehydrogenase activity | "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah] | 1 | 0.049724 | 52 |
| GO:MF | GO:0004754 | saccharopine dehydrogenase (NAD+, L-lysine-forming) activity | "Catalysis of the reaction: L-saccharopine + H2O + NAD+ = 2-oxoglutarate + L-lysine + H+ + NADH." [EC:1.5.1.7, RHEA:12440] | 1 | 0.049724 | 52 |
| GO:MF | GO:0016894 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters | "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah] | 1 | 0.049724 | 52 |
| GO:MF | GO:0047130 | saccharopine dehydrogenase (NADP+, L-lysine-forming) activity | "Catalysis of the reaction: L-saccharopine + H2O + NADP+ = 2-oxoglutarate + L-lysine + H+ + NADPH." [EC:1.5.1.8, RHEA:19373] | 1 | 0.049724 | 52 |
| GO:MF | GO:0047131 | saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity | "Catalysis of the reaction: L-saccharopine + H2O + NAD+ = L-glutamate + allysine + H+ + NADH." [EC:1.5.1.9, RHEA:24520] | 1 | 0.049724 | 52 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6079 | BAG6-HSPA2 complex | BAG6-HSPA2 complex | 1 | 0.049932 | 53 |
| CORUM | CORUM:6862 | Bag6-Ubl4A-Trc35 Complex | Bag6-Ubl4A-Trc35 Complex | 1 | 0.049932 | 53 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005674 | transcription factor TFIIF complex | "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077] | 1 | 0.049978 | 53 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004373 | alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity | "Catalysis of the reaction: [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H+ + UDP." [RHEA:18549] | 2 | 0.000015 | 54 |
| GO:MF | GO:0033840 | alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity | "Catalysis of the reaction: [(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H+, where NDP is ADP or UDP." [EC:2.4.1.242, PMID:17472966, RHEA:15873] | 2 | 0.000015 | 54 |
| GO:MF | GO:0035251 | UDP-glucosyltransferase activity | "Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule." [PMID:19858195] | 2 | 0.000324 | 54 |
| GO:MF | GO:0046527 | glucosyltransferase activity | "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] | 2 | 0.000840 | 54 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-3785653 | Myoclonic epilepsy of Lafora | Myoclonic epilepsy of Lafora | 2 | 0.000327 | 54 |
| REAC | REAC:R-HSA-3322077 | Glycogen synthesis | Glycogen synthesis | 2 | 0.000825 | 54 |
| REAC | REAC:R-HSA-3229121 | Glycogen storage diseases | Glycogen storage diseases | 2 | 0.000952 | 54 |
| REAC | REAC:R-HSA-8982491 | Glycogen metabolism | Glycogen metabolism | 2 | 0.002719 | 54 |
| REAC | REAC:R-HSA-5663084 | Diseases of carbohydrate metabolism | Diseases of carbohydrate metabolism | 2 | 0.004783 | 54 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP1403 | AMP activated protein kinase signaling | AMP activated protein kinase signaling | 2 | 0.002510 | 54 |
| WP | WP:WP3915 | Angiopoietin like protein 8 regulatory pathway | Angiopoietin like protein 8 regulatory pathway | 2 | 0.009816 | 54 |
| WP | WP:WP481 | Insulin signaling | Insulin signaling | 2 | 0.014442 | 54 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04922 | Glucagon signaling pathway | Glucagon signaling pathway | 2 | 0.004169 | 54 |
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 2 | 0.004248 | 54 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 2 | 0.005249 | 54 |
| KEGG | KEGG:04910 | Insulin signaling pathway | Insulin signaling pathway | 2 | 0.006849 | 54 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 2 | 0.046455 | 54 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] | 3 | 0.005839 | 54 |
| GO:BP | GO:0005978 | glycogen biosynthetic process | "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] | 2 | 0.006120 | 54 |
| GO:BP | GO:0009250 | glucan biosynthetic process | "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] | 2 | 0.006120 | 54 |
| GO:BP | GO:0005975 | carbohydrate metabolic process | "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] | 3 | 0.009448 | 54 |
| GO:BP | GO:0000271 | polysaccharide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] | 2 | 0.010061 | 54 |
| GO:BP | GO:0005977 | glycogen metabolic process | "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] | 2 | 0.023595 | 54 |
| GO:BP | GO:0044042 | glucan metabolic process | "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl] | 2 | 0.024738 | 54 |
| GO:BP | GO:0016239 | positive regulation of macroautophagy | "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] | 2 | 0.025907 | 54 |
| GO:BP | GO:0006112 | energy reserve metabolic process | "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] | 2 | 0.032157 | 54 |
| GO:BP | GO:0005976 | polysaccharide metabolic process | "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684] | 2 | 0.034845 | 54 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0005200 | structural constituent of cytoskeleton | "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] | 2 | 0.031523 | 55 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0046785 | microtubule polymerization | "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] | 2 | 0.032157 | 55 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0072686 | mitotic spindle | "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] | 2 | 0.038197 | 55 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 3 | 0.03919 | 55 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 2 | 0.03945 | 55 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0033257 | Bcl3/NF-kappaB2 complex | "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099] | 2 | 0.000002 | 56 |
| GO:CC | GO:0033256 | I-kappaB/NF-kappaB complex | "A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm." [GOC:bf, GOC:mah, PMID:9407099] | 2 | 0.000014 | 56 |
| GO:CC | GO:0032996 | Bcl3-Bcl10 complex | "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus." [PMID:16280327] | 1 | 0.024990 | 56 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002268 | follicular dendritic cell differentiation | "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149] | 2 | 0.000007 | 56 |
| GO:BP | GO:0002266 | follicular dendritic cell activation | "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789] | 2 | 0.000020 | 56 |
| GO:BP | GO:0038061 | non-canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217] | 3 | 0.000095 | 56 |
| GO:BP | GO:0002467 | germinal center formation | "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, ISBN:081533642X] | 2 | 0.000617 | 56 |
| GO:BP | GO:0007249 | canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217] | 3 | 0.001557 | 56 |
| GO:BP | GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831] | 3 | 0.003265 | 56 |
| GO:BP | GO:0048536 | spleen development | "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149] | 2 | 0.004765 | 56 |
| GO:BP | GO:0042088 | T-helper 1 type immune response | "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin." [GOC:add, ISBN:0781735149] | 2 | 0.007969 | 56 |
| GO:BP | GO:0042093 | T-helper cell differentiation | "The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell." [GOC:ebc] | 2 | 0.021932 | 56 |
| GO:BP | GO:0002294 | CD4-positive, alpha-beta T cell differentiation involved in immune response | "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] | 2 | 0.023034 | 56 |
| GO:BP | GO:0002293 | alpha-beta T cell differentiation involved in immune response | "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] | 2 | 0.023595 | 56 |
| GO:BP | GO:0002287 | alpha-beta T cell activation involved in immune response | "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] | 2 | 0.023595 | 56 |
| GO:BP | GO:0002250 | adaptive immune response | "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, ISBN:0781735149] | 3 | 0.023709 | 56 |
| GO:BP | GO:0002292 | T cell differentiation involved in immune response | "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] | 2 | 0.028326 | 56 |
| GO:BP | GO:0048534 | hematopoietic or lymphoid organ development | "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149] | 2 | 0.034845 | 56 |
| GO:BP | GO:0043367 | CD4-positive, alpha-beta T cell differentiation | "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell." [CL:0000624, ISBN:0781735149] | 2 | 0.035534 | 56 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2086 | NFKB1-NFKB2-RELA-RELB complex | NFKB1-NFKB2-RELA-RELB complex | 2 | 0.000044 | 56 |
| CORUM | CORUM:2084 | NFKB1-NFKB2-REL-RELA-RELB complex | NFKB1-NFKB2-REL-RELA-RELB complex | 2 | 0.000089 | 56 |
| CORUM | CORUM:5193 | TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) | TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) | 2 | 0.000664 | 56 |
| CORUM | CORUM:5232 | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) | 2 | 0.001550 | 56 |
| CORUM | CORUM:3046 | hs4 enhancer complex (slow migrating complex) | hs4 enhancer complex (slow migrating complex) | 1 | 0.049932 | 56 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | C-type lectin receptor signaling pathway | 3 | 0.000089 | 56 |
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | NF-kappa B signaling pathway | 2 | 0.021092 | 56 |
| KEGG | KEGG:04380 | Osteoclast differentiation | Osteoclast differentiation | 2 | 0.035319 | 56 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5272 | LDL influence on CD14 and TLR4 | LDL influence on CD14 and TLR4 | 2 | 0.001292 | 56 |
| WP | WP:WP5527 | NF kB signaling and ARTD family members | NF kB signaling and ARTD family members | 2 | 0.001929 | 56 |
| WP | WP:WP3858 | Toll like receptor signaling related to MyD88 | Toll like receptor signaling related to MyD88 | 2 | 0.002373 | 56 |
| WP | WP:WP3617 | Photodynamic therapy induced NF kB survival signaling | Photodynamic therapy induced NF kB survival signaling | 2 | 0.003035 | 56 |
| WP | WP:WP2203 | Thymic stromal lymphopoietin TSLP signaling | Thymic stromal lymphopoietin TSLP signaling | 2 | 0.003213 | 56 |
| WP | WP:WP4331 | Neovascularization processes | Neovascularization processes | 2 | 0.003397 | 56 |
| WP | WP:WP2036 | TNF related weak inducer of apoptosis TWEAK signaling | TNF related weak inducer of apoptosis TWEAK signaling | 2 | 0.003585 | 56 |
| WP | WP:WP5474 | Catabolism of skeletal muscle in cachexia | Catabolism of skeletal muscle in cachexia | 2 | 0.003977 | 56 |
| WP | WP:WP2018 | RANKL RANK signaling | RANKL RANK signaling | 2 | 0.006241 | 56 |
| WP | WP:WP5144 | NRP1 triggered signaling in pancreatic cancer | NRP1 triggered signaling in pancreatic cancer | 2 | 0.007019 | 56 |
| WP | WP:WP4329 | miRNA role in immune response in sepsis | miRNA role in immune response in sepsis | 2 | 0.009940 | 56 |
| WP | WP:WP4341 | Non genomic actions of 1 25 dihydroxyvitamin D3 | Non genomic actions of 1 25 dihydroxyvitamin D3 | 2 | 0.013736 | 56 |
| WP | WP:WP4217 | Ebola virus infection in host | Ebola virus infection in host | 2 | 0.041164 | 56 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | NIK-->noncanonical NF-kB signaling | 2 | 0.007765 | 56 |
| REAC | REAC:R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | Dectin-1 mediated noncanonical NF-kB signaling | 2 | 0.008032 | 56 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 2 | 0.021129 | 56 |
| REAC | REAC:R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | TNFR2 non-canonical NF-kB pathway | 2 | 0.022463 | 56 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 2 | 0.041659 | 56 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M03563_1 | Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 1 | Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 1 | 3 | 0.049998 | 56 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12516_1 | Factor: E2F6; motif: NNNGGCGGGAANN; match class: 1 | Factor: E2F6; motif: NNNGGCGGGAANN; match class: 1 | 3 | 0.016994 | 57 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-3928-3p | hsa-mir-3928-3p | hsa-mir-3928-3p | 2 | 0.034961 | 57 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0003075 | Hypoproteinemia | A decreased concentration of protein in the blood. | 2 | 0.025361 | 58 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0160129 | protein-DNA covalent cross-linking activity | "Catalysis of the cross-link between a protein and a DNA abasic site, forming a thiazolidine linkage between a DNA ring-opened abasic site and the alpha-amino and sulfhydryl substituents of cysteine residue of the protein." [PMID:30554877, PMID:31235913] | 1 | 0.049724 | 59 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6078 | HSPA2-ACR-PDIA6 complex | HSPA2-ACR-PDIA6 complex | 1 | 0.049932 | 59 |
| CORUM | CORUM:6079 | BAG6-HSPA2 complex | BAG6-HSPA2 complex | 1 | 0.049932 | 59 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-5700 | hsa-mir-5700 | hsa-mir-5700 | 2 | 0.020462 | 60 |
| MIRNA | MIRNA:hsa-mir-194-5p | hsa-mir-194-5p | hsa-mir-194-5p | 2 | 0.021038 | 60 |
| MIRNA | MIRNA:hsa-mir-4665-3p | hsa-mir-4665-3p | hsa-mir-4665-3p | 2 | 0.030626 | 60 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070160 | tight junction | "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181] | 2 | 0.020632 | 60 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 3 | 0.000296 | 63 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-156711 | Polo-like kinase mediated events | Polo-like kinase mediated events | 2 | 0.000952 | 63 |
| REAC | REAC:R-HSA-1538133 | G0 and Early G1 | G0 and Early G1 | 2 | 0.002945 | 63 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 3 | 0.022626 | 63 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 3 | 0.042851 | 63 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 0.022155 | 63 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 3 | 0.038053 | 63 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-8875513 | MET interacts with TNS proteins | MET interacts with TNS proteins | 2 | 0.000045 | 64 |
| REAC | REAC:R-HSA-8875878 | MET promotes cell motility | MET promotes cell motility | 2 | 0.003540 | 64 |
| REAC | REAC:R-HSA-6806834 | Signaling by MET | Signaling by MET | 2 | 0.012933 | 64 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2541 | HGF-Met complex | HGF-Met complex | 1 | 0.024966 | 64 |
| CORUM | CORUM:6798 | S1PR1-c-Met-ITGB4 complex, HGF- or S1P-induced | S1PR1-c-Met-ITGB4 complex, HGF- or S1P-induced | 1 | 0.049932 | 64 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0005008 | hepatocyte growth factor receptor activity | "Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] | 1 | 0.049724 | 64 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990026 | hippocampal mossy fiber expansion | "Synaptic expansion of hippocampal mossy fiber axon that makes contact with the thorny excrescences of hippocampal CA3 pyramidal cell dendrites." [NIF_Subcellular:nlx_subcell_1005002] | 1 | 0.041231 | 65 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4518 | Gamma glutamyl cycle for the biosynthesis and degradation of glutathione including diseases | Gamma glutamyl cycle for the biosynthesis and degradation of glutathione including diseases | 1 | 0.037462 | 66 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003921 | GMP synthase activity | "Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+." [RHEA:18301] | 1 | 0.049724 | 66 |
| GO:MF | GO:0003922 | GMP synthase (glutamine-hydrolyzing) activity | "Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+." [RHEA:11680] | 1 | 0.049724 | 66 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051373 | FATZ binding | "Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components." [PMID:10984498, PMID:11699871] | 2 | 0.000049 | 67 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0014888 | striated muscle adaptation | "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] | 2 | 0.007325 | 67 |
| GO:BP | GO:0045214 | sarcomere organization | "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] | 2 | 0.008639 | 67 |
| GO:BP | GO:0030239 | myofibril assembly | "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] | 2 | 0.019295 | 67 |
| GO:BP | GO:0043500 | muscle adaptation | "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] | 2 | 0.036932 | 67 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030018 | Z disc | "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] | 2 | 0.019435 | 67 |
| GO:CC | GO:0031674 | I band | "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] | 2 | 0.024110 | 67 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0062152 | mRNA (cytidine-5-)-methyltransferase activity | "Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H+ + S-adenosyl-L-homocysteine." [PMID:22395603, PMID:23871666, RHEA:61464] | 1 | 0.049724 | 69 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0045041 | Reduced circulating lactate dehydrogenase concentration | Concentration of lactate dehydrogenase in the blood circulation below the lower limit of normal. | 1 | 0.049962 | 70 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0016533 | protein kinase 5 complex | "A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent." [PMID:15689152] | 2 | 0.000007 | 71 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 2 | 0.005130 | 71 |
| GO:CC | GO:0031594 | neuromuscular junction | "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] | 2 | 0.007114 | 71 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 2 | 0.021554 | 71 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 2 | 0.026121 | 71 |
| GO:CC | GO:0043204 | perikaryon | "The portion of the cell soma (neuronal cell body) that excludes the nucleus." [GOC:jl] | 2 | 0.026809 | 71 |
| GO:CC | GO:0030426 | growth cone | "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] | 2 | 0.031498 | 71 |
| GO:CC | GO:0030427 | site of polarized growth | "Any part of a cell where non-isotropic growth takes place." [GOC:mah] | 2 | 0.033402 | 71 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9032845 | Activated NTRK2 signals through CDK5 | Activated NTRK2 signals through CDK5 | 2 | 0.000136 | 71 |
| REAC | REAC:R-HSA-9645723 | Diseases of programmed cell death | Diseases of programmed cell death | 3 | 0.000146 | 71 |
| REAC | REAC:R-HSA-399956 | CRMPs in Sema3A signaling | CRMPs in Sema3A signaling | 2 | 0.001088 | 71 |
| REAC | REAC:R-HSA-9006115 | Signaling by NTRK2 (TRKB) | Signaling by NTRK2 (TRKB) | 2 | 0.001904 | 71 |
| REAC | REAC:R-HSA-8863678 | Neurodegenerative Diseases | Neurodegenerative Diseases | 2 | 0.001904 | 71 |
| REAC | REAC:R-HSA-9768919 | NPAS4 regulates expression of target genes | NPAS4 regulates expression of target genes | 2 | 0.001904 | 71 |
| REAC | REAC:R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | 2 | 0.001904 | 71 |
| REAC | REAC:R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | Defective Intrinsic Pathway for Apoptosis | 2 | 0.002502 | 71 |
| REAC | REAC:R-HSA-9634815 | Transcriptional Regulation by NPAS4 | Transcriptional Regulation by NPAS4 | 2 | 0.004783 | 71 |
| REAC | REAC:R-HSA-9031628 | NGF-stimulated transcription | NGF-stimulated transcription | 2 | 0.006367 | 71 |
| REAC | REAC:R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | Nuclear Events (kinase and transcription factor activation) | 2 | 0.016008 | 71 |
| REAC | REAC:R-HSA-373755 | Semaphorin interactions | Semaphorin interactions | 2 | 0.018229 | 71 |
| REAC | REAC:R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | Signaling by Receptor Tyrosine Kinases | 3 | 0.018780 | 71 |
| REAC | REAC:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Regulation of TP53 Activity through Phosphorylation | 2 | 0.037785 | 71 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0021819 | layer formation in cerebral cortex | "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] | 2 | 0.000922 | 71 |
| GO:BP | GO:0090314 | positive regulation of protein targeting to membrane | "Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] | 2 | 0.002563 | 71 |
| GO:BP | GO:0021801 | cerebral cortex radial glia-guided migration | "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] | 2 | 0.002753 | 71 |
| GO:BP | GO:0022030 | telencephalon glial cell migration | "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.002753 | 71 |
| GO:BP | GO:0090313 | regulation of protein targeting to membrane | "Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] | 2 | 0.003803 | 71 |
| GO:BP | GO:0021799 | cerebral cortex radially oriented cell migration | "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] | 2 | 0.004765 | 71 |
| GO:BP | GO:0061001 | regulation of dendritic spine morphogenesis | "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] | 2 | 0.006709 | 71 |
| GO:BP | GO:0021795 | cerebral cortex cell migration | "The orderly movement of cells from one site to another in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.008300 | 71 |
| GO:BP | GO:0060997 | dendritic spine morphogenesis | "The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] | 2 | 0.011990 | 71 |
| GO:BP | GO:0008347 | glial cell migration | "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] | 2 | 0.012808 | 71 |
| GO:BP | GO:0022029 | telencephalon cell migration | "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.013228 | 71 |
| GO:BP | GO:0043525 | positive regulation of neuron apoptotic process | "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] | 2 | 0.014087 | 71 |
| GO:BP | GO:0021885 | forebrain cell migration | "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.014527 | 71 |
| GO:BP | GO:1903533 | regulation of protein targeting | "Any process that modulates the frequency, rate or extent of protein targeting." [GO_REF:0000058, GOC:TermGenie] | 2 | 0.019809 | 71 |
| GO:BP | GO:0018107 | peptidyl-threonine phosphorylation | "The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038] | 2 | 0.019809 | 71 |
| GO:BP | GO:0097061 | dendritic spine organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104] | 2 | 0.023034 | 71 |
| GO:BP | GO:0018210 | peptidyl-threonine modification | "The modification of peptidyl-threonine." [GOC:go_curators] | 2 | 0.025319 | 71 |
| GO:BP | GO:0106027 | neuron projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923] | 2 | 0.029576 | 71 |
| GO:BP | GO:0021766 | hippocampus development | "The progression of the hippocampus over time from its initial formation until its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421] | 2 | 0.031502 | 71 |
| GO:BP | GO:0060996 | dendritic spine development | "The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] | 2 | 0.034163 | 71 |
| GO:BP | GO:1905477 | positive regulation of protein localization to membrane | "Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] | 2 | 0.037641 | 71 |
| GO:BP | GO:0021549 | cerebellum development | "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] | 2 | 0.039808 | 71 |
| GO:BP | GO:0022037 | metencephalon development | "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] | 2 | 0.047469 | 71 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05030 | Cocaine addiction | Cocaine addiction | 2 | 0.004836 | 71 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5265 | Neurogenesis regulation in the olfactory epithelium | Neurogenesis regulation in the olfactory epithelium | 2 | 0.008127 | 71 |
| WP | WP:WP2380 | Brain derived neurotrophic factor BDNF signaling | Brain derived neurotrophic factor BDNF signaling | 2 | 0.047148 | 71 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 2 | 0.013236 | 71 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 2 | 0.013236 | 71 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity | "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [GOC:mah] | 3 | 6.939812e-08 | 72 |
| GO:MF | GO:0033192 | calmodulin-dependent protein phosphatase activity | "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118] | 2 | 4.911737e-05 | 72 |
| GO:MF | GO:0004722 | protein serine/threonine phosphatase activity | "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf] | 3 | 9.091153e-05 | 72 |
| GO:MF | GO:0004721 | phosphoprotein phosphatase activity | "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684] | 3 | 8.502604e-04 | 72 |
| GO:MF | GO:0016791 | phosphatase activity | "Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate." [GOC:curators, GOC:pg] | 3 | 2.344015e-03 | 72 |
| GO:MF | GO:0042578 | phosphoric ester hydrolase activity | "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl] | 3 | 4.671060e-03 | 72 |
| GO:MF | GO:0017018 | myosin phosphatase activity | "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16] | 2 | 1.875073e-02 | 72 |
| GO:MF | GO:0016788 | hydrolase activity, acting on ester bonds | "Catalysis of the hydrolysis of any ester bond." [GOC:jl] | 3 | 3.118444e-02 | 72 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5501 | GNAQ p R183Q drives capillary malformation | GNAQ p R183Q drives capillary malformation | 3 | 0.000001 | 72 |
| WP | WP:WP5142 | Calcium mediated T cell apoptosis involved in inclusion body myositis | Calcium mediated T cell apoptosis involved in inclusion body myositis | 2 | 0.000970 | 72 |
| WP | WP:WP3414 | Initiation of transcription and translation elongation at the HIV 1 LTR | Initiation of transcription and translation elongation at the HIV 1 LTR | 2 | 0.002531 | 72 |
| WP | WP:WP2447 | Amyotrophic lateral sclerosis ALS | Amyotrophic lateral sclerosis ALS | 2 | 0.003585 | 72 |
| WP | WP:WP1541 | Energy metabolism | Energy metabolism | 2 | 0.005509 | 72 |
| WP | WP:WP35 | G protein signaling | G protein signaling | 2 | 0.019892 | 72 |
| WP | WP:WP1544 | MicroRNAs in cardiomyocyte hypertrophy | MicroRNAs in cardiomyocyte hypertrophy | 2 | 0.027176 | 72 |
| WP | WP:WP428 | Wnt signaling | Wnt signaling | 2 | 0.032085 | 72 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0070884 | regulation of calcineurin-NFAT signaling cascade | "Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:ai] | 3 | 0.000003 | 72 |
| GO:BP | GO:0106056 | regulation of calcineurin-mediated signaling | "Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204] | 3 | 0.000003 | 72 |
| GO:BP | GO:0033173 | calcineurin-NFAT signaling cascade | "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+)." [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679] | 3 | 0.000005 | 72 |
| GO:BP | GO:0097720 | calcineurin-mediated signaling | "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544] | 3 | 0.000006 | 72 |
| GO:BP | GO:0050848 | regulation of calcium-mediated signaling | "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai] | 3 | 0.000051 | 72 |
| GO:BP | GO:1905949 | negative regulation of calcium ion import across plasma membrane | "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] | 2 | 0.000068 | 72 |
| GO:BP | GO:1905665 | positive regulation of calcium ion import across plasma membrane | "Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] | 2 | 0.000244 | 72 |
| GO:BP | GO:1905664 | regulation of calcium ion import across plasma membrane | "Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] | 2 | 0.000448 | 72 |
| GO:BP | GO:0019722 | calcium-mediated signaling | "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling] | 3 | 0.000680 | 72 |
| GO:BP | GO:0090281 | negative regulation of calcium ion import | "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] | 2 | 0.000712 | 72 |
| GO:BP | GO:0106058 | positive regulation of calcineurin-mediated signaling | "Any process that activates or increases the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204] | 2 | 0.001289 | 72 |
| GO:BP | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade | "Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade." [GOC:mah] | 2 | 0.001289 | 72 |
| GO:BP | GO:0090280 | positive regulation of calcium ion import | "Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] | 2 | 0.002034 | 72 |
| GO:BP | GO:0098703 | calcium ion import across plasma membrane | "The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] | 2 | 0.004515 | 72 |
| GO:BP | GO:1902656 | calcium ion import into cytosol | "The directed movement of calcium ion into a cytosol." [GO_REF:0000075, GOC:TermGenie, GOC:vw] | 2 | 0.004765 | 72 |
| GO:BP | GO:0048741 | skeletal muscle fiber development | "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle] | 2 | 0.005558 | 72 |
| GO:BP | GO:1903170 | negative regulation of calcium ion transmembrane transport | "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847] | 2 | 0.006411 | 72 |
| GO:BP | GO:0090279 | regulation of calcium ion import | "Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] | 2 | 0.007014 | 72 |
| GO:BP | GO:0014904 | myotube cell development | "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] | 2 | 0.007014 | 72 |
| GO:BP | GO:0050850 | positive regulation of calcium-mediated signaling | "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling." [GOC:ai] | 2 | 0.011590 | 72 |
| GO:BP | GO:0051926 | negative regulation of calcium ion transport | "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 2 | 0.011990 | 72 |
| GO:BP | GO:1904063 | negative regulation of cation transmembrane transport | "Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] | 2 | 0.019295 | 72 |
| GO:BP | GO:1904427 | positive regulation of calcium ion transmembrane transport | "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:22910094] | 2 | 0.021391 | 72 |
| GO:BP | GO:0070509 | calcium ion import | "The directed movement of calcium ions into a cell or organelle." [GOC:mah] | 2 | 0.022480 | 72 |
| GO:BP | GO:0034766 | negative regulation of monoatomic ion transmembrane transport | "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] | 2 | 0.023595 | 72 |
| GO:BP | GO:0043271 | negative regulation of monoatomic ion transport | "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] | 2 | 0.042792 | 72 |
| GO:BP | GO:0034763 | negative regulation of transmembrane transport | "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] | 2 | 0.043555 | 72 |
| GO:BP | GO:0051928 | positive regulation of calcium ion transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 2 | 0.045101 | 72 |
| GO:BP | GO:0099587 | inorganic ion import across plasma membrane | "The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] | 2 | 0.045883 | 72 |
| GO:BP | GO:0098659 | inorganic cation import across plasma membrane | "The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] | 2 | 0.045883 | 72 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2266 | PPP3CA-PPP3CA-RCAN1 complex | PPP3CA-PPP3CA-RCAN1 complex | 2 | 0.000015 | 72 |
| CORUM | CORUM:517 | AKAP5-PRKAR2A-PPP3CA complex | AKAP5-PRKAR2A-PPP3CA complex | 1 | 0.049932 | 72 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005955 | calcineurin complex | "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [PMID:26794871] | 2 | 0.000034 | 72 |
| GO:CC | GO:1903293 | phosphatase complex | "A protein complex which is capable of phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807] | 2 | 0.003470 | 72 |
| GO:CC | GO:0008287 | protein serine/threonine phosphatase complex | "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf] | 2 | 0.003470 | 72 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04921 | Oxytocin signaling pathway | Oxytocin signaling pathway | 3 | 0.000290 | 72 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 3 | 0.000583 | 72 |
| KEGG | KEGG:04370 | VEGF signaling pathway | VEGF signaling pathway | 2 | 0.007030 | 72 |
| KEGG | KEGG:04720 | Long-term potentiation | Long-term potentiation | 2 | 0.009078 | 72 |
| KEGG | KEGG:04924 | Renin secretion | Renin secretion | 2 | 0.009631 | 72 |
| KEGG | KEGG:05031 | Amphetamine addiction | Amphetamine addiction | 2 | 0.009631 | 72 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | B cell receptor signaling pathway | 2 | 0.013289 | 72 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | PD-L1 expression and PD-1 checkpoint pathway in cancer | 2 | 0.016051 | 72 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | Th1 and Th2 cell differentiation | 2 | 0.016051 | 72 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | C-type lectin receptor signaling pathway | 2 | 0.021928 | 72 |
| KEGG | KEGG:04659 | Th17 cell differentiation | Th17 cell differentiation | 2 | 0.022352 | 72 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | Glucagon signaling pathway | 2 | 0.023212 | 72 |
| KEGG | KEGG:04724 | Glutamatergic synapse | Glutamatergic synapse | 2 | 0.026813 | 72 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | T cell receptor signaling pathway | 2 | 0.028710 | 72 |
| KEGG | KEGG:04650 | Natural killer cell mediated cytotoxicity | Natural killer cell mediated cytotoxicity | 2 | 0.031172 | 72 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 2 | 0.034786 | 72 |
| KEGG | KEGG:04728 | Dopaminergic synapse | Dopaminergic synapse | 2 | 0.034786 | 72 |
| KEGG | KEGG:04380 | Osteoclast differentiation | Osteoclast differentiation | 2 | 0.035319 | 72 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 2 | 0.048665 | 72 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-180024 | DARPP-32 events | DARPP-32 events | 2 | 0.001148 | 72 |
| REAC | REAC:R-HSA-111885 | Opioid Signalling | Opioid Signalling | 2 | 0.017372 | 72 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0091063 | Cerebellum; synaptic glomeruli - core[High] | Cerebellum; synaptic glomeruli - core[High] | 2 | 0.023338 | 72 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05606 | Factor: ZNF691; motif: NAGGCCAGCCGC | Factor: ZNF691; motif: NAGGCCAGCCGC | 2 | 0.013303 | 74 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:29 | PA28gamma complex | PA28gamma complex | 1 | 0.024966 | 74 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:4000039 | Reduced mucosal-associated invariant T cell proportion | A decreased proportion of circulating mucosal-associated invariant T (MAIT) cells relative to total T cell count. | 1 | 0.049962 | 74 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7403 | SREBP-1a-PKM2 complex | SREBP-1a-PKM2 complex | 1 | 0.049932 | 75 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2390 | CD98-LAT2-ITGB1 complex | CD98-LAT2-ITGB1 complex | 2 | 0.000089 | 76 |
| CORUM | CORUM:2431 | ITGA2-ITGB1-COL6A3 complex | ITGA2-ITGB1-COL6A3 complex | 1 | 0.049988 | 76 |
| CORUM | CORUM:2413 | ITGA6-ITGB1 complex | ITGA6-ITGB1 complex | 1 | 0.049988 | 76 |
| CORUM | CORUM:2418 | ITGA4-ITGB1 complex | ITGA4-ITGB1 complex | 1 | 0.049988 | 76 |
| CORUM | CORUM:2421 | ITGA4-ITGB1-VCAM1 complex | ITGA4-ITGB1-VCAM1 complex | 1 | 0.049988 | 76 |
| CORUM | CORUM:2432 | ITGA2-ITGB1 complex | ITGA2-ITGB1 complex | 1 | 0.049988 | 76 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-210991 | Basigin interactions | Basigin interactions | 2 | 0.002719 | 76 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0089718 | amino acid import across plasma membrane | "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] | 2 | 0.008639 | 76 |
| GO:BP | GO:1902475 | L-alpha-amino acid transmembrane transport | "The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore." [GOC:kmv, GOC:TermGenie, PMID:14668347] | 2 | 0.016353 | 76 |
| GO:BP | GO:0015807 | L-amino acid transport | "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] | 2 | 0.027711 | 76 |
| GO:BP | GO:0003333 | amino acid transmembrane transport | "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb] | 2 | 0.037641 | 76 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 2 | 0.014486 | 76 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 2 | 0.014486 | 76 |
| GO:CC | GO:0044225 | apical pole of neuron | "Portion of a neuron cell soma closest to the point where the apical dendrite emerges." [NIF_Subcellular:sao1186862860] | 1 | 0.024990 | 76 |
| GO:CC | GO:0034677 | integrin alpha7-beta1 complex | "An integrin complex that comprises one alpha7 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.024990 | 76 |
| GO:CC | GO:0034665 | integrin alpha1-beta1 complex | "An integrin complex that comprises one alpha1 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 76 |
| GO:CC | GO:0034667 | integrin alpha3-beta1 complex | "An integrin complex that comprises one alpha3 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 76 |
| GO:CC | GO:0034674 | integrin alpha5-beta1 complex | "An integrin complex that comprises one alpha5 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 76 |
| GO:CC | GO:0034678 | integrin alpha8-beta1 complex | "An integrin complex that comprises one alpha8 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 76 |
| GO:CC | GO:0034679 | integrin alpha9-beta1 complex | "An integrin complex that comprises one alpha9 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 76 |
| GO:CC | GO:0034675 | integrin alpha6-beta1 complex | "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 76 |
| GO:CC | GO:0034682 | integrin alphav-beta1 complex | "An integrin complex that comprises one alphav subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 76 |
| GO:CC | GO:0034681 | integrin alpha11-beta1 complex | "An integrin complex that comprises one alpha11 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 76 |
| GO:CC | GO:0034680 | integrin alpha10-beta1 complex | "An integrin complex that comprises one alpha10 subunit and one beta1 subunit." [PMID:12297042] | 1 | 0.049978 | 76 |
| GO:CC | GO:1990184 | amino acid transport complex | "A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane." [GOC:kmv, PMID:14668347] | 1 | 0.049978 | 76 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0001618 | virus receptor activity | "Combining with a virus component and mediating entry of the virus into the cell." [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183] | 2 | 0.015096 | 76 |
| GO:MF | GO:0140272 | exogenous protein binding | "Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein." [PMID:28861068] | 2 | 0.015483 | 76 |
| GO:MF | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity | "Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] | 1 | 0.049724 | 76 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03271 | Virion - Rotavirus | Virion - Rotavirus | 1 | 0.035006 | 76 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04015 | Rap1 signaling pathway | Rap1 signaling pathway | 2 | 0.016133 | 79 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0098928 | presynaptic signal transduction | "Signal transduction in which the initial step occurs in a presynapse." [GOC:dos] | 1 | 0.049542 | 79 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005814 | centriole | "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] | 2 | 0.012139 | 80 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0019918 | peptidyl-arginine methylation, to symmetrical-dimethyl arginine | "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine." [RESID:AA0067, RESID:AA0069] | 1 | 0.049542 | 81 |
| GO:BP | GO:0035247 | peptidyl-arginine omega-N-methylation | "The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein." [PMID:14705965, RESID:AA0067, RESID:AA0068, RESID:AA0069] | 1 | 0.049542 | 81 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5030 | Ethylmalonic encephalopathy | Ethylmalonic encephalopathy | 1 | 0.029803 | 82 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008482 | sulfite oxidase activity | "Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate." [RHEA:24600] | 1 | 0.049891 | 82 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:75 | TSC1-TSC2 complex | TSC1-TSC2 complex | 1 | 0.049932 | 82 |
| CORUM | CORUM:7157 | TSC1-TSC2 complex | TSC1-TSC2 complex | 1 | 0.049932 | 82 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 2 | 0.009587 | 83 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 2 | 0.017389 | 83 |
| KEGG | KEGG:04010 | MAPK signaling pathway | MAPK signaling pathway | 2 | 0.033193 | 83 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4666 | Hepatitis B infection | Hepatitis B infection | 2 | 0.013029 | 83 |
| WP | WP:WP382 | MAPK signaling | MAPK signaling | 2 | 0.033936 | 83 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0042641 | actomyosin | "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] | 2 | 0.003982 | 85 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-516a-5p | hsa-mir-516a-5p | hsa-mir-516a-5p | 2 | 0.01023 | 87 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0098957 | anterograde axonal transport of mitochondrion | "The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [GOC:dos] | 2 | 0.000035 | 88 |
| GO:BP | GO:0019896 | axonal transport of mitochondrion | "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai] | 2 | 0.000361 | 88 |
| GO:BP | GO:0048311 | mitochondrion distribution | "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid] | 2 | 0.000403 | 88 |
| GO:BP | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated | "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220] | 2 | 0.000891 | 88 |
| GO:BP | GO:0047497 | mitochondrion transport along microtubule | "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd] | 2 | 0.000891 | 88 |
| GO:BP | GO:0051654 | establishment of mitochondrion localization | "The directed movement of the mitochondrion to a specific location." [GOC:ai] | 2 | 0.001322 | 88 |
| GO:BP | GO:0047496 | vesicle transport along microtubule | "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl] | 2 | 0.002547 | 88 |
| GO:BP | GO:0008089 | anterograde axonal transport | "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194] | 2 | 0.003004 | 88 |
| GO:BP | GO:0051646 | mitochondrion localization | "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] | 2 | 0.003247 | 88 |
| GO:BP | GO:0099518 | vesicle cytoskeletal trafficking | "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl] | 2 | 0.004750 | 88 |
| GO:BP | GO:0098930 | axonal transport | "The directed movement of organelles or molecules along microtubules in axons." [ISBN:0815316194] | 2 | 0.005528 | 88 |
| GO:BP | GO:0008088 | axo-dendritic transport | "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194] | 2 | 0.008019 | 88 |
| GO:BP | GO:0072384 | organelle transport along microtubule | "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] | 2 | 0.009437 | 88 |
| GO:BP | GO:0010970 | transport along microtubule | "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] | 2 | 0.037119 | 88 |
| GO:BP | GO:0051650 | establishment of vesicle localization | "The directed movement of a vesicle to a specific location." [GOC:ai] | 2 | 0.046891 | 88 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:177 | OGT-TRAK1-TRAK2 complex | OGT-TRAK1-TRAK2 complex | 2 | 0.000044 | 88 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9013425 | RHOT1 GTPase cycle | RHOT1 GTPase cycle | 2 | 0.000045 | 88 |
| REAC | REAC:R-HSA-9013419 | RHOT2 GTPase cycle | RHOT2 GTPase cycle | 2 | 0.000095 | 88 |
| REAC | REAC:R-HSA-9715370 | Miro GTPase Cycle | Miro GTPase Cycle | 2 | 0.000127 | 88 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0050811 | GABA receptor binding | "Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai] | 2 | 0.000335 | 88 |
| GO:MF | GO:0017022 | myosin binding | "Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah] | 2 | 0.007023 | 88 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1904115 | axon cytoplasm | "Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152] | 2 | 0.001877 | 88 |
| GO:CC | GO:0120111 | neuron projection cytoplasm | "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha] | 2 | 0.003645 | 88 |
| GO:CC | GO:0032838 | plasma membrane bounded cell projection cytoplasm | "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah] | 2 | 0.035582 | 88 |
| GO:CC | GO:0099568 | cytoplasmic region | "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos] | 2 | 0.045450 | 88 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0009328 | phenylalanine-tRNA ligase complex | "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [PMID:20223217] | 1 | 0.019977 | 91 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0140466 | iron-sulfur cluster export from the mitochondrion | "The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane." [PMID:31040179] | 1 | 0.049542 | 92 |
| GO:BP | GO:1902497 | iron-sulfur cluster transmembrane transport | "A process in which an iron-sulfur cluster is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:19810706] | 1 | 0.049542 | 92 |
| GO:BP | GO:1903329 | regulation of iron-sulfur cluster assembly | "Any process that modulates the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 1 | 0.049542 | 92 |
| GO:BP | GO:1903331 | positive regulation of iron-sulfur cluster assembly | "Any process that activates or increases the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 1 | 0.049542 | 92 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140481 | ABC-type iron-sulfur cluster transporter activity | "Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out)." [PMID:31040179] | 1 | 0.049891 | 92 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1369007 | Mitochondrial ABC transporters | Mitochondrial ABC transporters | 1 | 0.049932 | 92 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034499 | Increased bone marrow iron | An increased amount of iron in the bone marrow. | 1 | 0.049962 | 92 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1250 | RB-E2F1 complex | RB-E2F1 complex | 1 | 0.049932 | 94 |
| CORUM | CORUM:5143 | RB-E2F1 complex | RB-E2F1 complex | 1 | 0.049932 | 94 |
| CORUM | CORUM:6588 | E2F-1-DP-1 complex | E2F-1-DP-1 complex | 1 | 0.049932 | 94 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb] | 2 | 0.022274 | 95 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] | 2 | 0.034652 | 95 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1544 | PPP2CA-PPP2R1A-PPP2R3A complex | PPP2CA-PPP2R1A-PPP2R3A complex | 1 | 0.049932 | 95 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005947 | Decreased sensitivity to hypoxemia | Reduced tendency to respond to a reduced concentration of oxygen in the blood by increasing respiration. | 1 | 0.049962 | 96 |
| HP | HP:6000993 | Pupillary hypersensitivity to parasympathomimetic agents | A higher than normal tendency of parasympathomimetic agents to induce miosis. | 1 | 0.049962 | 96 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0044858 | plasma membrane raft polarization | "The clustering and aggregation of a plasma membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity." [GOC:jl] | 1 | 0.049542 | 99 |
| GO:BP | GO:1903906 | regulation of plasma membrane raft polarization | "Any process that modulates the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] | 1 | 0.049542 | 99 |
| GO:BP | GO:1905707 | negative regulation of mitochondrial ATP synthesis coupled proton transport | "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport." [GO_REF:0000058, GOC:TermGenie, PMID:12809520, PMID:15294286] | 1 | 0.049542 | 99 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032614 | Renal glomerular amyloid deposition | Amyloid deposits located in the glomeruli in a focal segmental, diffuse segmental or diffuse global fashion. This abnormality can be accompanied by mesangial involvement and in later stages also involvement of the peripheral capillaries. | 1 | 0.049962 | 99 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0036255 | response to methylamine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [GOC:mah] | 1 | 0.049542 | 101 |
| GO:BP | GO:1903442 | response to lipoic acid | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760] | 1 | 0.049542 | 101 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004375 | glycine dehydrogenase (decarboxylating) activity | "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2] | 1 | 0.049891 | 101 |
| GO:MF | GO:0016642 | oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] | 1 | 0.049891 | 101 |
| GO:MF | GO:0070280 | pyridoxal binding | "Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6." [CHEBI:17310, GOC:mah] | 1 | 0.049891 | 101 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 2 | 0.048406 | 102 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 2 | 0.049918 | 102 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05473_1 | Factor: DRRS; motif: NTTTTCNATTGA; match class: 1 | Factor: DRRS; motif: NTTTTCNATTGA; match class: 1 | 1 | 0.049771 | 102 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-5188 | hsa-mir-5188 | hsa-mir-5188 | 1 | 0.018076 | 104 |
| MIRNA | MIRNA:hsa-mir-132-5p | hsa-mir-132-5p | hsa-mir-132-5p | 1 | 0.038412 | 104 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0071757 | hexameric IgM immunoglobulin complex | "A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268] | 1 | 0.020616 | 104 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4186 | Somatroph axis GH and its relationship to dietary restriction and aging | Somatroph axis GH and its relationship to dietary restriction and aging | 1 | 0.037462 | 104 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1703 | IGHM-VPREB1-IGLL1 complex | IGHM-VPREB1-IGLL1 complex | 1 | 0.049932 | 104 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990660 | calprotectin complex | "A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways." [GOC:bhm, PMID:25417112] | 1 | 0.041231 | 105 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6826 | Calprotectin heterotetramer | Calprotectin heterotetramer | 1 | 0.049932 | 105 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0048211 | Golgi vesicle docking | "The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] | 1 | 0.049542 | 106 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0061723 | glycophagy | "The selective degradation of glycogen by macroautophagy." [GOC:autophagy, PMID:21893048] | 2 | 0.000156 | 108 |
| GO:BP | GO:0030242 | autophagy of peroxisome | "The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110] | 2 | 0.000283 | 108 |
| GO:BP | GO:0044804 | nucleophagy | "A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded." [GOC:autophagy, GOC:jl, PMID:24013549] | 2 | 0.000596 | 108 |
| GO:BP | GO:0005980 | glycogen catabolic process | "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] | 2 | 0.000766 | 108 |
| GO:BP | GO:0009251 | glucan catabolic process | "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] | 2 | 0.000827 | 108 |
| GO:BP | GO:0000272 | polysaccharide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480] | 2 | 0.000957 | 108 |
| GO:BP | GO:0005977 | glycogen metabolic process | "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] | 2 | 0.008214 | 108 |
| GO:BP | GO:0044042 | glucan metabolic process | "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl] | 2 | 0.008612 | 108 |
| GO:BP | GO:0006112 | energy reserve metabolic process | "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] | 2 | 0.011200 | 108 |
| GO:BP | GO:0005976 | polysaccharide metabolic process | "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684] | 2 | 0.012137 | 108 |
| GO:BP | GO:0000422 | autophagy of mitochondrion | "The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344] | 2 | 0.012866 | 108 |
| GO:BP | GO:0000045 | autophagosome assembly | "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464] | 2 | 0.016266 | 108 |
| GO:BP | GO:1905037 | autophagosome organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024] | 2 | 0.018262 | 108 |
| GO:BP | GO:0016052 | carbohydrate catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 2 | 0.035057 | 108 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0034045 | phagophore assembly site membrane | "A cellular membrane associated with the phagophore assembly site." [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324] | 2 | 0.000215 | 108 |
| GO:CC | GO:0000407 | phagophore assembly site | "Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655] | 2 | 0.000726 | 108 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04136 | Autophagy - other | Autophagy - other | 2 | 0.000365 | 108 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | Spinocerebellar ataxia | 2 | 0.007256 | 108 |
| KEGG | KEGG:04140 | Autophagy - animal | Autophagy - animal | 2 | 0.009947 | 108 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 2 | 0.034083 | 108 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 2 | 0.048303 | 108 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0032266 | phosphatidylinositol-3-phosphate binding | "Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775] | 2 | 0.002551 | 108 |
| GO:MF | GO:1901981 | phosphatidylinositol phosphate binding | "Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487] | 2 | 0.040145 | 108 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 2 | 0.038228 | 108 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 2 | 0.039715 | 108 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002065 | columnar/cuboidal epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] | 2 | 0.015446 | 109 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0046627 | negative regulation of insulin receptor signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] | 2 | 0.001746 | 110 |
| GO:BP | GO:1900077 | negative regulation of cellular response to insulin stimulus | "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] | 2 | 0.001838 | 110 |
| GO:BP | GO:0046626 | regulation of insulin receptor signaling pathway | "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] | 2 | 0.005210 | 110 |
| GO:BP | GO:1900076 | regulation of cellular response to insulin stimulus | "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] | 2 | 0.006023 | 110 |
| GO:BP | GO:0008286 | insulin receptor signaling pathway | "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] | 2 | 0.017969 | 110 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0030971 | receptor tyrosine kinase binding | "Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah] | 2 | 0.007985 | 110 |
| GO:MF | GO:1990782 | protein tyrosine kinase binding | "Binding to protein tyrosine kinase." [PMID:25499537] | 2 | 0.019718 | 110 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP481 | Insulin signaling | Insulin signaling | 2 | 0.014442 | 110 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3634 | Insulin signaling in adipocytes normal condition | Insulin signaling in adipocytes normal condition | 1 | 0.04995 | 111 |
| WP | WP:WP3635 | Insulin signaling in adipocytes diabetic condition | Insulin signaling in adipocytes diabetic condition | 1 | 0.04995 | 111 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2947 | YY1-Notch1 complex | YY1-Notch1 complex | 1 | 0.024966 | 113 |
| CORUM | CORUM:2907 | RBP-Jkappa-Notch1 complex | RBP-Jkappa-Notch1 complex | 1 | 0.049932 | 113 |
| CORUM | CORUM:2946 | YY1-Notch1-RBP-Jkappa complex | YY1-Notch1-RBP-Jkappa complex | 1 | 0.049932 | 113 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0003178 | coronary sinus valve development | "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart] | 1 | 0.049542 | 113 |
| GO:BP | GO:0003182 | coronary sinus valve morphogenesis | "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart] | 1 | 0.049542 | 113 |
| GO:BP | GO:0003270 | Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation | "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] | 1 | 0.049542 | 113 |
| GO:BP | GO:0060843 | venous endothelial cell differentiation | "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb] | 1 | 0.049542 | 113 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | FBXW7 Mutants and NOTCH1 in Cancer | 1 | 0.049932 | 113 |
| REAC | REAC:R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 1 | 0.049932 | 113 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0025107 | Cutis marmorata telangiectatica congenita | A congenital vascular malformation that presents as localized or generalized erythematous-telangiectatic lesions with a reticular pattern; the lesions are almost always present at birth or develop in the first days of life. Cutis marmorata telangiectatica congenita (CMTC) appears as marble-like pattern (mottling) on the surface of the skin. In contrast to cutis marmorata, the marbling is more severe and always visible. | 1 | 0.049962 | 113 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0060698 | endoribonuclease inhibitor activity | "Binds to and stops, prevents or reduces the activity of endoribonuclease." [GOC:dph, GOC:tb] | 1 | 0.049891 | 114 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3181 | LMO4-CREB complex | LMO4-CREB complex | 1 | 0.024966 | 116 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0098784 | biofilm matrix organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a biofilm matrix." [GOC:mah] | 1 | 0.049542 | 117 |
| GO:BP | GO:0098786 | biofilm matrix disassembly | "A process that results in the disassembly of a biofilm matrix." [GOC:mah] | 1 | 0.049542 | 117 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4818 | Conversion of angiotensinogen to angiotensin II | Conversion of angiotensinogen to angiotensin II | 1 | 0.049667 | 117 |
| WP | WP:WP5442 | Wnt Beta catenin signaling inhibitors in current and past clinical trials | Wnt Beta catenin signaling inhibitors in current and past clinical trials | 1 | 0.049667 | 117 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00524 | Neomycin, kanamycin and gentamicin biosynthesis | Neomycin, kanamycin and gentamicin biosynthesis | 1 | 0.009598 | 118 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047931 | glucosamine kinase activity | "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H+." [RHEA:10948] | 1 | 0.049891 | 118 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5619056 | Defective HK1 causes hexokinase deficiency (HK deficiency) | Defective HK1 causes hexokinase deficiency (HK deficiency) | 1 | 0.049932 | 118 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5211 | Glucose metabolism in triple negative breast cancer cells | Glucose metabolism in triple negative breast cancer cells | 1 | 0.04995 | 118 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:6000559 | Reduced erythrocyte hexokinase activity | Activity or concentration of hexokinase (EC 2.7.1.1) in red blood cells below the lower limit of normal. Arginase catalyzes the last step of the urea cycle. | 1 | 0.049962 | 118 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2486 | GIPC1-LHCGR complex | GIPC1-LHCGR complex | 1 | 0.049932 | 120 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M01592_1 | Factor: LBP9; motif: CCRGNNNNARCCRGYYN; match class: 1 | Factor: LBP9; motif: CCRGNNNNARCCRGYYN; match class: 1 | 2 | 0.015399 | 121 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4877 | Host pathogen interaction of human coronaviruses MAPK signaling | Host pathogen interaction of human coronaviruses MAPK signaling | 2 | 0.000715 | 122 |
| WP | WP:WP3915 | Angiopoietin like protein 8 regulatory pathway | Angiopoietin like protein 8 regulatory pathway | 2 | 0.009816 | 122 |
| WP | WP:WP481 | Insulin signaling | Insulin signaling | 2 | 0.014442 | 122 |
| WP | WP:WP382 | MAPK signaling | MAPK signaling | 2 | 0.033936 | 122 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043507 | positive regulation of JUN kinase activity | "Any process that activates or increases the frequency, rate or extent of JUN kinase activity." [GOC:jl] | 2 | 0.000827 | 122 |
| GO:BP | GO:0043506 | regulation of JUN kinase activity | "Any process that modulates the frequency, rate or extent of JUN kinase activity." [GOC:jl] | 2 | 0.001746 | 122 |
| GO:BP | GO:0043406 | positive regulation of MAP kinase activity | "Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] | 2 | 0.005855 | 122 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 2 | 0.006539 | 122 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 2 | 0.012866 | 122 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 2 | 0.014647 | 122 |
| GO:BP | GO:0043405 | regulation of MAP kinase activity | "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] | 2 | 0.015446 | 122 |
| GO:BP | GO:0071902 | positive regulation of protein serine/threonine kinase activity | "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] | 2 | 0.021631 | 122 |
| GO:BP | GO:0009411 | response to UV | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] | 2 | 0.028123 | 122 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 2 | 0.031495 | 122 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 2 | 0.042756 | 122 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04912 | GnRH signaling pathway | GnRH signaling pathway | 2 | 0.003145 | 122 |
| KEGG | KEGG:04010 | MAPK signaling pathway | MAPK signaling pathway | 2 | 0.033193 | 122 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0031434 | mitogen-activated protein kinase kinase binding | "Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase." [GOC:mah] | 2 | 0.000163 | 123 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2077 | B-raf-MAP3K11 complex | B-raf-MAP3K11 complex | 1 | 0.049932 | 123 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1901187 | regulation of ephrin receptor signaling pathway | "Any process that modulates the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie] | 1 | 0.049542 | 124 |
| GO:BP | GO:1901189 | positive regulation of ephrin receptor signaling pathway | "Any process that activates or increases the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie] | 1 | 0.049542 | 124 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2907 | RBP-Jkappa-Notch1 complex | RBP-Jkappa-Notch1 complex | 1 | 0.049932 | 124 |
| CORUM | CORUM:2908 | RBP-Jkappa-SHARP complex | RBP-Jkappa-SHARP complex | 1 | 0.049932 | 124 |
| CORUM | CORUM:2946 | YY1-Notch1-RBP-Jkappa complex | YY1-Notch1-RBP-Jkappa complex | 1 | 0.049932 | 124 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06394 | Factor: ZNF761; motif: KGGTTGATCGGA | Factor: ZNF761; motif: KGGTTGATCGGA | 1 | 0.049771 | 125 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005498 | Midline skin dimples over anterior/posterior fontanelles | Midline skin dimples over anterior/posterior fontanelles | 1 | 0.049962 | 125 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0048306 | calcium-dependent protein binding | "Binding to a protein or protein complex in the presence of calcium." [GOC:jid, PMID:10485905] | 2 | 0.007593 | 126 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 2 | 0.033450 | 127 |
| GO:BP | GO:0009443 | pyridoxal 5'-phosphate salvage | "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl] | 1 | 0.049542 | 127 |
| GO:BP | GO:0042817 | pyridoxal metabolic process | "The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, PMID:21767669] | 1 | 0.049542 | 127 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00750 | Vitamin B6 metabolism | Vitamin B6 metabolism | 1 | 0.037408 | 127 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4315 | Malate aspartate shuttle | Malate aspartate shuttle | 1 | 0.039736 | 127 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008478 | pyridoxal kinase activity | "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35] | 1 | 0.049891 | 127 |
| GO:MF | GO:0047860 | diiodophenylpyruvate reductase activity | "Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H+ + NADH." [EC:1.1.1.96, RHEA:20293] | 1 | 0.049891 | 127 |
| GO:MF | GO:0047995 | hydroxyphenylpyruvate reductase activity | "Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH." [RHEA:10780] | 1 | 0.049891 | 127 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05032 | Morphine addiction | Morphine addiction | 2 | 0.002879 | 128 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | Parathyroid hormone synthesis, secretion and action | 2 | 0.004014 | 128 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] | 2 | 0.004602 | 128 |
| GO:BP | GO:0008277 | regulation of G protein-coupled receptor signaling pathway | "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] | 2 | 0.028123 | 128 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP289 | Myometrial relaxation and contraction pathways | Myometrial relaxation and contraction pathways | 2 | 0.013376 | 128 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5383 | TRIB3-DDIT3 complex | TRIB3-DDIT3 complex | 1 | 0.049932 | 130 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-165158 | Activation of AKT2 | Activation of AKT2 | 1 | 0.049932 | 130 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0070593 | dendrite self-avoidance | "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551] | 2 | 0.000247 | 133 |
| GO:BP | GO:0008038 | neuron recognition | "The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators] | 2 | 0.002547 | 133 |
| GO:BP | GO:0008037 | cell recognition | "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators] | 2 | 0.029598 | 133 |
| GO:BP | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] | 2 | 0.033450 | 133 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051371 | muscle alpha-actinin binding | "Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165] | 2 | 0.000259 | 133 |
| GO:MF | GO:0051393 | alpha-actinin binding | "Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." [PMID:10984498, PMID:11699871, PMID:15014165] | 2 | 0.000932 | 133 |
| GO:MF | GO:0042805 | actinin binding | "Binding to actinin, any member of a family of proteins that crosslink F-actin." [GOC:jl, ISBN:0198506732] | 2 | 0.001732 | 133 |
| GO:MF | GO:0098632 | cell-cell adhesion mediator activity | "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion] | 2 | 0.003527 | 133 |
| GO:MF | GO:0098631 | cell adhesion mediator activity | "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion] | 2 | 0.005951 | 133 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030018 | Z disc | "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] | 2 | 0.008048 | 133 |
| GO:CC | GO:0031674 | I band | "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] | 2 | 0.009989 | 133 |
| GO:CC | GO:0030017 | sarcomere | "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] | 2 | 0.022017 | 133 |
| GO:CC | GO:0030016 | myofibril | "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] | 2 | 0.026696 | 133 |
| GO:CC | GO:0043292 | contractile muscle fiber | "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] | 2 | 0.028972 | 133 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902612 | regulation of anti-Mullerian hormone signaling pathway | "Any process that modulates the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077] | 1 | 0.049542 | 134 |
| GO:BP | GO:1902613 | negative regulation of anti-Mullerian hormone signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077] | 1 | 0.049542 | 134 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6599 | CTNND1-GLIS2 complex | CTNND1-GLIS2 complex | 1 | 0.049932 | 135 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-570-3p | hsa-mir-570-3p | hsa-mir-570-3p | 2 | 0.013105 | 137 |
| MIRNA | MIRNA:hsa-mir-548f-5p | hsa-mir-548f-5p | hsa-mir-548f-5p | 2 | 0.031230 | 137 |
| MIRNA | MIRNA:hsa-mir-548aj-5p | hsa-mir-548aj-5p | hsa-mir-548aj-5p | 2 | 0.031492 | 137 |
| MIRNA | MIRNA:hsa-mir-548g-5p | hsa-mir-548g-5p | hsa-mir-548g-5p | 2 | 0.031492 | 137 |
| MIRNA | MIRNA:hsa-mir-548x-5p | hsa-mir-548x-5p | hsa-mir-548x-5p | 2 | 0.031492 | 137 |
| MIRNA | MIRNA:hsa-mir-548aw | hsa-mir-548aw | hsa-mir-548aw | 2 | 0.032821 | 137 |
| MIRNA | MIRNA:hsa-mir-1468-3p | hsa-mir-1468-3p | hsa-mir-1468-3p | 2 | 0.033090 | 137 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 2 | 0.031495 | 137 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6242 | 14-3-3q-SGK1-tau complex | 14-3-3q-SGK1-tau complex | 1 | 0.049932 | 137 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0006916 | Intraaxonal accumulation of curvilinear autofluorescent lipopigment storage material | Curvilinear intracellular accumulation of autofluorescent lipopigment storage material within axons. | 1 | 0.049962 | 137 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-210-5p | hsa-mir-210-5p | hsa-mir-210-5p | 2 | 0.000992 | 140 |
| MIRNA | MIRNA:hsa-mir-6756-3p | hsa-mir-6756-3p | hsa-mir-6756-3p | 2 | 0.016148 | 140 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3154 | Notch2(N-TM)-Notch2(N-EC)-Delta complex | Notch2(N-TM)-Notch2(N-EC)-Delta complex | 1 | 0.049932 | 140 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005463 | Elongated sella turcica | Elongated sella turcica | 1 | 0.049962 | 140 |
| HP | HP:0006180 | Crowded carpal bones | Crowded carpal bones | 1 | 0.049962 | 140 |
| HP | HP:0008421 | Tall lumbar vertebral bodies | Tall lumbar vertebral bodies | 1 | 0.049962 | 140 |
| HP | HP:0008424 | Hypoplastic 5th lumbar vertebrae | Hypoplastic 5th lumbar vertebrae | 1 | 0.049962 | 140 |
| HP | HP:0011305 | Partial absence of toe | The absence of a phalangeal segment of a toe or hallux. | 1 | 0.049962 | 140 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0010992 | Stress urinary incontinence | Involuntary urine leakage synchronous with exertion, or actions such as sneezing, or coughing. | 1 | 0.049962 | 141 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1903754 | cortical microtubule plus-end | "The plus-end of a cortical microtubule." [GO_REF:0000064, GOC:TermGenie, GOC:vw] | 1 | 0.041231 | 143 |
| GO:CC | GO:1904511 | cytoplasmic microtubule plus-end | "Any microtubule plus-end that is part of a cytoplasmic microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:15772152] | 1 | 0.041231 | 143 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032219 | Increased proportion of CD4-positive T cells | Abnormal increase of helper CD3+CD4+ T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population. | 1 | 0.049962 | 143 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0320873 | Nasopharynx; ciliated cells (ciliary rootlets)[High] | Nasopharynx; ciliated cells (ciliary rootlets)[High] | 2 | 0.013108 | 145 |
| HPA | HPA:0210873 | Fallopian tube; ciliated cells (ciliary rootlets)[High] | Fallopian tube; ciliated cells (ciliary rootlets)[High] | 2 | 0.033208 | 145 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002204 | somatic recombination of immunoglobulin genes involved in immune response | "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149] | 2 | 0.003629 | 147 |
| GO:BP | GO:0002208 | somatic diversification of immunoglobulins involved in immune response | "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701] | 2 | 0.003629 | 147 |
| GO:BP | GO:0045190 | isotype switching | "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [ISBN:0781735149] | 2 | 0.003629 | 147 |
| GO:BP | GO:0002381 | immunoglobulin production involved in immunoglobulin-mediated immune response | "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:9185563] | 2 | 0.004171 | 147 |
| GO:BP | GO:0016447 | somatic recombination of immunoglobulin gene segments | "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149] | 2 | 0.004750 | 147 |
| GO:BP | GO:0016445 | somatic diversification of immunoglobulins | "The somatic process that results in the generation of sequence diversity of immunoglobulins." [GOC:add, GOC:ma, ISBN:0781735149] | 2 | 0.005528 | 147 |
| GO:BP | GO:0002562 | somatic diversification of immune receptors via germline recombination within a single locus | "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] | 2 | 0.006192 | 147 |
| GO:BP | GO:0016444 | somatic cell DNA recombination | "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma] | 2 | 0.006192 | 147 |
| GO:BP | GO:0002200 | somatic diversification of immune receptors | "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] | 2 | 0.007260 | 147 |
| GO:BP | GO:0002312 | B cell activation involved in immune response | "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal] | 2 | 0.009649 | 147 |
| GO:BP | GO:0002377 | immunoglobulin production | "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] | 2 | 0.013363 | 147 |
| GO:BP | GO:0002520 | immune system development | "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] | 2 | 0.048312 | 147 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004642 | phosphoribosylformylglycinamidine synthase activity | "Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate." [EC:6.3.5.3, RHEA:17129] | 1 | 0.049891 | 148 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070381 | endosome to plasma membrane transport vesicle | "A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah, PMID:10679016, PMID:12110576] | 1 | 0.041231 | 149 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0097753 | membrane bending | "A membrane organization process resulting in the bending of a membrane." [GOC:krc, GOC:pr, GOC:vw, Wikipedia:Membrane_curvature] | 1 | 0.049542 | 149 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004676 | 3-phosphoinositide-dependent protein kinase activity | "Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah] | 1 | 0.049891 | 152 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-165158 | Activation of AKT2 | Activation of AKT2 | 1 | 0.049932 | 152 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04211 | Longevity regulating pathway | Longevity regulating pathway | 2 | 0.002879 | 153 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | Glucagon signaling pathway | 2 | 0.004169 | 153 |
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 2 | 0.004248 | 153 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 2 | 0.005249 | 153 |
| KEGG | KEGG:04714 | Thermogenesis | Thermogenesis | 2 | 0.019700 | 153 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 2 | 0.034083 | 153 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4321 | Thermogenesis | Thermogenesis | 2 | 0.00656 | 153 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043622 | cortical microtubule organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] | 2 | 0.000085 | 154 |
| GO:BP | GO:0030865 | cortical cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] | 2 | 0.003761 | 154 |
| GO:BP | GO:0031122 | cytoplasmic microtubule organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] | 2 | 0.005054 | 154 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | Receptor-type tyrosine-protein phosphatases | 2 | 0.000776 | 154 |
| REAC | REAC:R-HSA-6794362 | Protein-protein interactions at synapses | Protein-protein interactions at synapses | 2 | 0.016586 | 154 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0048786 | presynaptic active zone | "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] | 2 | 0.003982 | 154 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 2 | 0.049918 | 154 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0033140 | Blake's pouch cyst | The presence of an upwardly displaced normal cerebellar vermis, normal appearance of the fastigium, tentorium and size of the cisterna magna. | 1 | 0.049962 | 154 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00220 | Arginine biosynthesis | Arginine biosynthesis | 1 | 0.042233 | 156 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0070953 | regulation of neutrophil mediated killing of fungus | "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a fungal cell, the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] | 1 | 0.049542 | 156 |
| GO:BP | GO:0070965 | positive regulation of neutrophil mediated killing of fungus | "Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] | 1 | 0.049542 | 156 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0035921 | desmosome disassembly | "The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:BHF, GOC:vk, ISBN:0198506732, PMID:9182671] | 1 | 0.049542 | 157 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12609_1 | Factor: FPM315; motif: SNSNGTSCTCCCNN; match class: 1 | Factor: FPM315; motif: SNSNGTSCTCCCNN; match class: 1 | 2 | 0.001742 | 158 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2650 | DNMT3B-DNMT3L complex | DNMT3B-DNMT3L complex | 1 | 0.049932 | 158 |
| CORUM | CORUM:2651 | DNMT3L-DNMT3A complex | DNMT3L-DNMT3A complex | 1 | 0.049932 | 158 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5465 | Fanconi anemia | Fanconi anemia | 2 | 0.001227 | 159 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0035825 | homologous recombination | "A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules." [GOC:mah, PMID:11139492, PMID:17304215] | 2 | 0.005368 | 159 |
| GO:BP | GO:0000724 | double-strand break repair via homologous recombination | "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] | 2 | 0.041420 | 159 |
| GO:BP | GO:0000725 | recombinational repair | "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] | 2 | 0.043658 | 159 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0141055 | histone H3 ubiquitin ligase activity | "Catalysis of the transfer of ubiquitin to a histone H3 substrate." [PMID:25303536] | 1 | 0.049891 | 159 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0020083 | Furuncle | An infection of a hair follicle that extends subcutaneously, forming an abscess. | 1 | 0.049962 | 161 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1904797 | negative regulation of core promoter binding | "Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] | 1 | 0.049542 | 164 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5282 | CAS-SRC-FAK complex | CAS-SRC-FAK complex | 1 | 0.049932 | 165 |
| CORUM | CORUM:5712 | FAK-beta5 integrin complex, VEGF induced | FAK-beta5 integrin complex, VEGF induced | 1 | 0.049932 | 165 |
| CORUM | CORUM:6916 | CTTN-FER-PTK2 complex | CTTN-FER-PTK2 complex | 1 | 0.049932 | 165 |
| CORUM | CORUM:6925 | MAPK1-PTK2-PXN complex | MAPK1-PTK2-PXN complex | 1 | 0.049932 | 165 |
| CORUM | CORUM:7116 | GRB7-PTK2 complex | GRB7-PTK2 complex | 1 | 0.049932 | 165 |
| CORUM | CORUM:7416 | GJB2-PTK2-NANOG complex | GJB2-PTK2-NANOG complex | 1 | 0.049932 | 165 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9674555 | Signaling by CSF3 (G-CSF) | Signaling by CSF3 (G-CSF) | 2 | 0.001974 | 166 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04630 | JAK-STAT signaling pathway | JAK-STAT signaling pathway | 2 | 0.009587 | 166 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051463 | negative regulation of cortisol secretion | "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai] | 1 | 0.049542 | 166 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051916 | granulocyte colony-stimulating factor binding | "Binding to granulocyte colony-stimulating factor, G-CSF." [GOC:ai] | 1 | 0.049891 | 166 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3183 | PDGFRA-SHP-2 complex, PDGF stimulated | PDGFRA-SHP-2 complex, PDGF stimulated | 1 | 0.049932 | 166 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-662 | hsa-mir-662 | hsa-mir-662 | 2 | 0.034452 | 169 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1090 | APLG1-Rababtin5 complex | APLG1-Rababtin5 complex | 1 | 0.049932 | 169 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5658442 | Regulation of RAS by GAPs | Regulation of RAS by GAPs | 2 | 0.010034 | 170 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0044301 | climbing fiber | "The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber." [NIF_Subcellular:nlx_subcell_20090203] | 1 | 0.041231 | 170 |
| GO:CC | GO:1990032 | parallel fiber | "A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium." [ISBN:0195159551, NIF_Subcellular:nlx_330] | 1 | 0.041231 | 170 |
| GO:CC | GO:1990597 | AIP1-IRE1 complex | "A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein)." [GOC:bf, GOC:PARL, PMID:18281285] | 1 | 0.041231 | 170 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043087 | regulation of GTPase activity | "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] | 2 | 0.047836 | 170 |
| GO:BP | GO:2000257 | regulation of protein activation cascade | "Any process that modulates the frequency, rate or extent of protein activation cascade." [GOC:mah] | 1 | 0.049542 | 170 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990533 | Dom34-Hbs1 complex | "A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay." [GOC:mcc, PMID:20890290, PMID:21102444, PMID:21448132, PMID:22503425] | 1 | 0.041231 | 173 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-489-5p | hsa-mir-489-5p | hsa-mir-489-5p | 1 | 0.018269 | 174 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-15869 | Metabolism of nucleotides | Metabolism of nucleotides | 2 | 0.018583 | 176 |
| REAC | REAC:R-HSA-5263617 | Metabolism of ingested MeSeO2H into MeSeH | Metabolism of ingested MeSeO2H into MeSeH | 1 | 0.049932 | 176 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004637 | phosphoribosylamine-glycine ligase activity | "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate." [EC:6.3.4.13, RHEA:17453] | 1 | 0.049891 | 176 |
| GO:MF | GO:0004641 | phosphoribosylformylglycinamidine cyclo-ligase activity | "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate." [EC:6.3.3.1, RHEA:23032] | 1 | 0.049891 | 176 |
| GO:MF | GO:0004644 | phosphoribosylglycinamide formyltransferase activity | "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2] | 1 | 0.049891 | 176 |
| GO:MF | GO:0050137 | NADPH peroxidase activity | "Catalysis of the reaction: H2O2 + H+ + NADPH = 2 H2O + NADP+." [EC:1.11.1.2, RHEA:15173] | 1 | 0.049891 | 176 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5153 | CTFC-TAF1 complex | CTFC-TAF1 complex | 1 | 0.049932 | 177 |
| CORUM | CORUM:6989 | ProTalpha C9 complex | ProTalpha C9 complex | 1 | 0.049932 | 177 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:rno-mir-203a-3p | rno-mir-203a-3p | rno-mir-203a-3p | 1 | 0.018269 | 178 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0071142 | homomeric SMAD protein complex | "A protein complex composed of a single type of SMAD family proteins. In the absence of Smad4, phosphorylation of R-SMADs results in their homotrimerization. However, these complexes do not appear to import into the nucleus and are assumed to be transcriptionally inactive." [GOC:bhm, GOC:mah, PMID:11779505, PMID:16322555, PMID:9670020] | 1 | 0.041231 | 178 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2642 | SMAD1-P300 complex | SMAD1-P300 complex | 1 | 0.049932 | 178 |
| CORUM | CORUM:2958 | SMAD1-CBP complex | SMAD1-CBP complex | 1 | 0.049932 | 178 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1296 | DCP1A-DCP2 Decapping complex | DCP1A-DCP2 Decapping complex | 1 | 0.049932 | 180 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0070102 | interleukin-6-mediated signaling pathway | "The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling] | 2 | 0.000361 | 181 |
| GO:BP | GO:0071354 | cellular response to interleukin-6 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 2 | 0.001169 | 181 |
| GO:BP | GO:0070741 | response to interleukin-6 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 2 | 0.001569 | 181 |
| GO:BP | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb] | 2 | 0.005691 | 181 |
| GO:BP | GO:0043433 | negative regulation of DNA-binding transcription factor activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl] | 2 | 0.019758 | 181 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9616222 | Transcriptional regulation of granulopoiesis | Transcriptional regulation of granulopoiesis | 2 | 0.016977 | 181 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100658 | Cellulitis | A bacterial infection and inflammation of the skin und subcutaneous tissues. | 2 | 0.042597 | 181 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011997 | Postprandial hyperlactemia | Abnormally increased level of blood lactate following a meal. | 1 | 0.049962 | 182 |
| HP | HP:6000979 | Reduced hepatic glycogen phosphorylase activity | Activity or concentration of glycogen phosphorylase L in the liver below the lower limit of normal. | 1 | 0.049962 | 182 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0091022 | Cerebellum; processes in granular layer[≥Medium] | Cerebellum; processes in granular layer[≥Medium] | 2 | 0.016508 | 183 |
| HPA | HPA:0091021 | Cerebellum; processes in granular layer[≥Low] | Cerebellum; processes in granular layer[≥Low] | 2 | 0.022230 | 183 |
| HPA | HPA:0090972 | Cerebellum; granular cells - cytoplasm/membrane[≥Medium] | Cerebellum; granular cells - cytoplasm/membrane[≥Medium] | 2 | 0.028305 | 183 |
| HPA | HPA:0090971 | Cerebellum; granular cells - cytoplasm/membrane[≥Low] | Cerebellum; granular cells - cytoplasm/membrane[≥Low] | 2 | 0.047018 | 183 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:ebv-mir-bart12 | ebv-mir-bart12 | ebv-mir-bart12 | 1 | 0.018269 | 183 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0150051 | postsynaptic Golgi apparatus | "The network of the Golgi apparatus structures located within the postsynapse." [GOC:aruk, GOC:bc, PMID:23838184] | 1 | 0.041231 | 183 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0032271 | regulation of protein polymerization | "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 2 | 0.046422 | 183 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140489 | molecular template activity | "The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence." [GOC:pg] | 1 | 0.049891 | 183 |
| GO:MF | GO:0140490 | microtubule nucleator activity | "The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly." [PMID:20631709, PMID:21993292] | 1 | 0.049891 | 183 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2276 | Glial cell differentiation | Glial cell differentiation | 1 | 0.04995 | 183 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04217 | Necroptosis | Necroptosis | 2 | 0.009118 | 185 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6254 | GPC-4.1R-p55 complex | GPC-4.1R-p55 complex | 1 | 0.049932 | 186 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0411263 | Retina; outer plexiform layer[High] | Retina; outer plexiform layer[High] | 1 | 0.049944 | 186 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0033157 | regulation of intracellular protein transport | "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] | 2 | 0.027041 | 187 |
| GO:BP | GO:2001025 | positive regulation of response to drug | "Any process that activates or increases the frequency, rate or extent of response to drug." [GOC:obol] | 1 | 0.049542 | 187 |
| GO:BP | GO:2001040 | positive regulation of cellular response to drug | "Any process that activates or increases the frequency, rate or extent of cellular response to drug." [GOC:obol] | 1 | 0.049542 | 187 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6668 | GLIS3-SUFU complex | GLIS3-SUFU complex | 1 | 0.049932 | 187 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030121 | AP-1 adaptor complex | "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499] | 2 | 0.000073 | 188 |
| GO:CC | GO:0030130 | clathrin coat of trans-Golgi network vesicle | "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah] | 2 | 0.000159 | 188 |
| GO:CC | GO:0012510 | trans-Golgi network transport vesicle membrane | "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai] | 2 | 0.000195 | 188 |
| GO:CC | GO:0030131 | clathrin adaptor complex | "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] | 2 | 0.000327 | 188 |
| GO:CC | GO:0030125 | clathrin vesicle coat | "A clathrin coat found on a vesicle." [GOC:mah] | 2 | 0.000554 | 188 |
| GO:CC | GO:0030140 | trans-Golgi network transport vesicle | "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah] | 2 | 0.000690 | 188 |
| GO:CC | GO:0030119 | AP-type membrane coat adaptor complex | "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838] | 2 | 0.000841 | 188 |
| GO:CC | GO:0030118 | clathrin coat | "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549] | 2 | 0.001187 | 188 |
| GO:CC | GO:0030660 | Golgi-associated vesicle membrane | "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] | 2 | 0.001539 | 188 |
| GO:CC | GO:0030120 | vesicle coat | "A membrane coat found on a coated vesicle." [GOC:mah] | 2 | 0.001818 | 188 |
| GO:CC | GO:0005798 | Golgi-associated vesicle | "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] | 2 | 0.004245 | 188 |
| GO:CC | GO:0030117 | membrane coat | "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] | 2 | 0.004515 | 188 |
| GO:CC | GO:0048475 | coated membrane | "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid] | 2 | 0.004515 | 188 |
| GO:CC | GO:0030665 | clathrin-coated vesicle membrane | "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah] | 2 | 0.008419 | 188 |
| GO:CC | GO:0030662 | coated vesicle membrane | "The lipid bilayer surrounding a coated vesicle." [GOC:mah] | 2 | 0.018523 | 188 |
| GO:CC | GO:0030136 | clathrin-coated vesicle | "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894] | 2 | 0.022424 | 188 |
| GO:CC | GO:0030658 | transport vesicle membrane | "The lipid bilayer surrounding a transport vesicle." [GOC:mah] | 2 | 0.029673 | 188 |
| GO:CC | GO:0030135 | coated vesicle | "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] | 2 | 0.046916 | 188 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2000158 | positive regulation of ubiquitin-specific protease activity | "Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol] | 1 | 0.049542 | 189 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005437 | Recurrent infections in infancy and early childhood | Recurrent infections at an early age with improvement in later childhood. | 1 | 0.049962 | 190 |
| HP | HP:6000517 | Elevated monolysocardiolipin/cardiolipin ratio | The concentration of monolysocardiolipin related to that of cardiolipin is above the upper limit of normal. This is a functional assay that can be performed from a blood spot to diagnose Barth syndrome (OMIM:302060). | 1 | 0.049962 | 190 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-432722 | Golgi Associated Vesicle Biogenesis | Golgi Associated Vesicle Biogenesis | 2 | 0.006739 | 191 |
| REAC | REAC:R-HSA-199992 | trans-Golgi Network Vesicle Budding | trans-Golgi Network Vesicle Budding | 2 | 0.011926 | 191 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:mir-370 | mir-370 | mir-370 | 1 | 0.018269 | 191 |
| MIRNA | MIRNA:hsa-mir-6821-3p | hsa-mir-6821-3p | hsa-mir-6821-3p | 2 | 0.039876 | 191 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04144 | Endocytosis | Endocytosis | 2 | 0.022517 | 191 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1072 | SNX complex (SNX2), oligomeric | SNX complex (SNX2), oligomeric | 1 | 0.049932 | 191 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb] | 2 | 0.022274 | 192 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] | 2 | 0.034652 | 192 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3125 | TLE1 homodimer complex | TLE1 homodimer complex | 1 | 0.024966 | 192 |
| CORUM | CORUM:3127 | TLE-Histone H3 complex | TLE-Histone H3 complex | 1 | 0.024966 | 192 |
| CORUM | CORUM:3120 | OCT1-OBF1-DNA-TLE1 complex | OCT1-OBF1-DNA-TLE1 complex | 1 | 0.049932 | 192 |
| CORUM | CORUM:3124 | TLE1-TLE2 complex | TLE1-TLE2 complex | 1 | 0.049932 | 192 |
| CORUM | CORUM:3150 | NK-3-Groucho complex | NK-3-Groucho complex | 1 | 0.049932 | 192 |
| CORUM | CORUM:3164 | HESX1-TLE1 complex | HESX1-TLE1 complex | 1 | 0.049932 | 192 |
| CORUM | CORUM:6769 | TBX20-TLE1 repressor complex | TBX20-TLE1 repressor complex | 1 | 0.049932 | 192 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0032602 | chemokine production | "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, ISBN:0198506732, PMID:12183377, Wikipedia:Chemokine] | 2 | 0.010745 | 193 |
| GO:BP | GO:0032642 | regulation of chemokine production | "Any process that modulates the frequency, rate, or extent of chemokine production." [GOC:mah] | 2 | 0.010745 | 193 |
| GO:BP | GO:1902350 | cellular response to chloroquine | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869] | 1 | 0.049542 | 193 |
| GO:BP | GO:1905298 | regulation of intestinal epithelial cell development | "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] | 1 | 0.049542 | 193 |
| GO:BP | GO:1905300 | positive regulation of intestinal epithelial cell development | "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] | 1 | 0.049542 | 193 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-111446 | Activation of BIM and translocation to mitochondria | Activation of BIM and translocation to mitochondria | 1 | 0.037449 | 194 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0110027 | negative regulation of DNA strand resection involved in replication fork processing | "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing." [GOC:mah, PMID:28475874] | 1 | 0.049542 | 194 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006530 | asparagine catabolic process | "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] | 1 | 0.049542 | 195 |
| GO:BP | GO:0033345 | asparagine catabolic process via L-aspartate | "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah] | 1 | 0.049542 | 195 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-200425 | Carnitine shuttle | Carnitine shuttle | 2 | 0.000413 | 196 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0019217 | regulation of fatty acid metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] | 2 | 0.010300 | 196 |
| GO:BP | GO:0010565 | regulation of ketone metabolic process | "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] | 2 | 0.018853 | 196 |
| GO:BP | GO:0006633 | fatty acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] | 2 | 0.029598 | 196 |
| GO:BP | GO:0046722 | lactic acid secretion | "The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue." [GOC:ai] | 1 | 0.049542 | 196 |
| GO:BP | GO:0090459 | intracellular aspartate homeostasis | "A homeostatic process involved in the maintenance of a steady state level of aspartate within a cell." [GOC:tb] | 1 | 0.049542 | 196 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00061 | Fatty acid biosynthesis | Fatty acid biosynthesis | 1 | 0.034554 | 196 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002048 | Renal cortical atrophy | Atrophy of the cortex of the kidney. | 1 | 0.049962 | 197 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2542 | Sulindac metabolic pathway | Sulindac metabolic pathway | 1 | 0.049667 | 198 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9851151 | MDK and PTN in ALK signaling | MDK and PTN in ALK signaling | 1 | 0.049932 | 200 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:4200 | DNM1L-FIS1 complex | DNM1L-FIS1 complex | 1 | 0.049932 | 203 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12525_1 | Factor: MAFF; motif: NWGTCAGCATTTTNNN; match class: 1 | Factor: MAFF; motif: NWGTCAGCATTTTNNN; match class: 1 | 1 | 0.049771 | 204 |
| TF | TF:M12545_1 | Factor: MAFG; motif: NAGTCAGCATTTNNN; match class: 1 | Factor: MAFG; motif: NAGTCAGCATTTNNN; match class: 1 | 1 | 0.049771 | 204 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003968 | RNA-directed RNA polymerase activity | "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf] | 1 | 0.049891 | 204 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2812 | RPAP1-RPB2-RPB3 complex | RPAP1-RPB2-RPB3 complex | 1 | 0.049932 | 204 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030056 | hemidesmosome | "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195] | 2 | 0.000020 | 206 |
| GO:CC | GO:0005604 | basement membrane | "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [PMID:22505934, PMID:33605520, PMID:39223427] | 2 | 0.003982 | 206 |
| GO:CC | GO:0009925 | basal plasma membrane | "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] | 2 | 0.039547 | 206 |
| GO:CC | GO:0031673 | H zone | "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131] | 1 | 0.041231 | 206 |
| GO:CC | GO:0045178 | basal part of cell | "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] | 2 | 0.044870 | 206 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045104 | intermediate filament cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai] | 2 | 0.010300 | 206 |
| GO:BP | GO:0045103 | intermediate filament-based process | "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins." [GOC:ai] | 2 | 0.010521 | 206 |
| GO:BP | GO:0007229 | integrin-mediated signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] | 2 | 0.015717 | 206 |
| GO:BP | GO:0045175 | basal protein localization | "Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf] | 1 | 0.049542 | 206 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0012822 | Bilateral vocal cord paresis | Decreased strength of the vocal fold on both sides. | 1 | 0.049962 | 206 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M04775_1 | Factor: TCF-4; motif: NCTTTGATS; match class: 1 | Factor: TCF-4; motif: NCTTTGATS; match class: 1 | 2 | 0.04448 | 207 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-198765 | Signalling to ERK5 | Signalling to ERK5 | 1 | 0.024966 | 208 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1990547 | mitochondrial phosphate ion transmembrane transport | "The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9099701] | 1 | 0.049542 | 208 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0015317 | phosphate:proton symporter activity | "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-] | 1 | 0.049891 | 208 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097546 | ciliary base | "Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444] | 2 | 0.001006 | 211 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4249 | Hedgehog signaling | Hedgehog signaling | 2 | 0.001025 | 211 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04340 | Hedgehog signaling pathway | Hedgehog signaling pathway | 2 | 0.001132 | 211 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5610783 | Degradation of GLI2 by the proteasome | Degradation of GLI2 by the proteasome | 2 | 0.008032 | 211 |
| REAC | REAC:R-HSA-5610787 | Hedgehog 'off' state | Hedgehog 'off' state | 2 | 0.028717 | 211 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M09979_1 | Factor: MafF; motif: TGCTGASTCAGCANTTTT; match class: 1 | Factor: MafF; motif: TGCTGASTCAGCANTTTT; match class: 1 | 2 | 0.039466 | 212 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005788 | endoplasmic reticulum lumen | "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] | 2 | 0.04545 | 213 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032105 | Macrosaccadic oscillations | A type of saccadic oscillations with brief periods of fixation between saccades (intersaccadic interval approximately 200 msec). Macrosaccadic oscillations (up to 40 degrees) straddle the intended fixation position and show a crescendo-decrescendo pattern. | 1 | 0.049962 | 214 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0045253 | pyruvate dehydrogenase (lipoamide) phosphatase complex | "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [PMID:9395502] | 1 | 0.019977 | 215 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00511 | Other glycan degradation | Other glycan degradation | 1 | 0.034554 | 216 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004560 | alpha-L-fucosidase activity | "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51] | 1 | 0.049891 | 216 |
| GO:MF | GO:0015928 | fucosidase activity | "Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative." [GOC:ai] | 1 | 0.049891 | 216 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0004630 | Anterior beaking of thoracic vertebrae | Anterior tongue-like protrusions of thoracic vertebral bodies. | 1 | 0.049962 | 216 |
| HP | HP:0008436 | Absent/hypoplastic coccyx | Absent/hypoplastic coccyx | 1 | 0.049962 | 216 |
| HP | HP:0034727 | Reduced circulating alpha-L-fucosidase activity | Activity of the enzyme alpha-L-fucosidase below the lower limit of normal. | 1 | 0.049962 | 216 |
| HP | HP:0034728 | Abnormal circulating alpha-L-fucosidase activity | Activity of the enzyme alpha-L-fucosidase in the blood circulation outside the limits of normal. | 1 | 0.049962 | 216 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990130 | GATOR1 complex | "A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins." [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950] | 1 | 0.049943 | 218 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032047 | Focal cortical dysplasia type I | A type of focal cortical dysplasia that is characterized by abnormal cortical layering. | 1 | 0.049962 | 218 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7127 | GSKIP-GSK3B-PRKAR2A complex | GSKIP-GSK3B-PRKAR2A complex | 1 | 0.049932 | 219 |
| CORUM | CORUM:7128 | GSKIP-GSK3B-PRKAR2A complex | GSKIP-GSK3B-PRKAR2A complex | 1 | 0.049932 | 219 |
| CORUM | CORUM:7129 | GSKIP-PRKAR2B complex | GSKIP-PRKAR2B complex | 1 | 0.049932 | 219 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031298 | replication fork protection complex | "A heterotrimeric replication-pausing complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. Required for maximal fork speed both in vivo and in vitro." [PMID:12944972, PMID:15367656, PMID:19819872] | 1 | 0.029966 | 221 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6869-3p | hsa-mir-6869-3p | hsa-mir-6869-3p | 1 | 0.020336 | 222 |
| MIRNA | MIRNA:hsa-mir-548ad-3p | hsa-mir-548ad-3p | hsa-mir-548ad-3p | 1 | 0.040671 | 222 |
| MIRNA | MIRNA:hsa-mir-6503-3p | hsa-mir-6503-3p | hsa-mir-6503-3p | 1 | 0.042931 | 222 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0072356 | chromosome passenger complex localization to kinetochore | "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis." [GOC:mah] | 1 | 0.049542 | 222 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1247-5p | hsa-mir-1247-5p | hsa-mir-1247-5p | 1 | 0.042931 | 224 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0060517 | epithelial cell proliferation involved in prostatic bud elongation | "The multiplication of epithelial cells, contributing to the expansion of the primary prostatic bud." [GOC:dph, PMID:18977204] | 1 | 0.049542 | 224 |
| GO:BP | GO:0060784 | regulation of cell proliferation involved in tissue homeostasis | "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." [GOC:dph] | 1 | 0.049542 | 224 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008477 | Poorly ossified cervical vertebrae | Decreased ossification of the cervical vertebral bodies, i.e., of the Cervical vertebrae set. | 1 | 0.049962 | 224 |
| HP | HP:0032538 | Pretibial dimple | A groove or crease on the shins (pretibial, i.e., over the shin bone). Pretibial creases may be obvious at birth and may range from 3 cm to over 15 cm in length and lengthen as the limb grows. They appear as an elongated dimple because of the attachment of skin to underlying tissue (e.g., to the tibia). The dimple or crease grows in proportion to the growth of the leg. | 1 | 0.049962 | 224 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00061 | Fatty acid biosynthesis | Fatty acid biosynthesis | 1 | 0.034554 | 226 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-434313 | Intracellular metabolism of fatty acids regulates insulin secretion | Intracellular metabolism of fatty acids regulates insulin secretion | 1 | 0.037449 | 226 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6840-5p | hsa-mir-6840-5p | hsa-mir-6840-5p | 1 | 0.042931 | 232 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3297 | EV release from cardiac cells and their functional effects | EV release from cardiac cells and their functional effects | 1 | 0.043706 | 232 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047191 | 1-alkylglycerophosphocholine O-acyltransferase activity | "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.63, MetaCyc:2.3.1.63-RXN] | 1 | 0.024946 | 234 |
| GO:MF | GO:0047159 | plasmalogen synthase activity | "Catalysis of the reaction: 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA." [RHEA:10344] | 1 | 0.049891 | 234 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2001246 | negative regulation of phosphatidylcholine biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol] | 1 | 0.049542 | 234 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004463 | leukotriene-A4 hydrolase activity | "Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22324] | 1 | 0.024946 | 236 |
| GO:MF | GO:0034701 | tripeptidase activity | "Catalysis of the hydrolysis of a tripeptide." [GOC:mah] | 1 | 0.024946 | 236 |
| GO:MF | GO:0045148 | tripeptide aminopeptidase activity | "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide." [EC:3.4.11.4] | 1 | 0.024946 | 236 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9020265 | Biosynthesis of aspirin-triggered D-series resolvins | Biosynthesis of aspirin-triggered D-series resolvins | 1 | 0.024966 | 236 |
| REAC | REAC:R-HSA-9018676 | Biosynthesis of D-series resolvins | Biosynthesis of D-series resolvins | 1 | 0.037449 | 236 |
| REAC | REAC:R-HSA-9023661 | Biosynthesis of E-series 18(R)-resolvins | Biosynthesis of E-series 18(R)-resolvins | 1 | 0.037449 | 236 |
| REAC | REAC:R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | Biosynthesis of E-series 18(S)-resolvins | 1 | 0.049932 | 236 |
| REAC | REAC:R-HSA-9018681 | Biosynthesis of protectins | Biosynthesis of protectins | 1 | 0.049932 | 236 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034572 | Pigment incontinence | A process in which melanosomes (melanin granules) are deposited in the dermis. The dermal melanosomes are observed to be mainly in macrophages. This phenomenon of pigmentary incontinence usually follows an inflammatory process with the basic feature of basal cell damage, such as in lichen planus, lupus erythematosus, Riehl's melanosis, incontinentia pigmenti (Bloch-Sulzberger), and fixed drug eruption. Incontinence of pigment, or dropping off of epidermal melanin into the dermis, frequently produces a clinically recognizable and characteristic slate-gray pigmentation. | 1 | 0.049962 | 237 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034405 | Enlarged tectum | Increasaed size of the tectum, which is the region of the midbrain posterior to the cerebral aqueduct of Sylvius. The midbrain is the most superior portion of the brainstem. | 1 | 0.049962 | 238 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070701 | mucus layer | "An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes." [GOC:krc, GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394, Wikipedia:Mucin] | 1 | 0.019977 | 242 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0044611 | nuclear pore inner ring | "A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] | 1 | 0.029966 | 246 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004347 | glucose-6-phosphate isomerase activity | "Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate." [RHEA:11816] | 1 | 0.049891 | 250 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0003568 | Decreased glucosephosphate isomerase level | A decreased level of glucose-6-phosphate isomerase. | 1 | 0.049962 | 250 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 1 | 0.037449 | 251 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6310 | DEAF1- complex | DEAF1- complex | 1 | 0.024966 | 255 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05312_1 | Factor: FKLF; motif: AGGGCGGGTG; match class: 1 | Factor: FKLF; motif: AGGGCGGGTG; match class: 1 | 1 | 0.037328 | 255 |
| TF | TF:M05552_1 | Factor: SP5; motif: NGGGCGGGTS; match class: 1 | Factor: SP5; motif: NGGGCGGGTS; match class: 1 | 1 | 0.037328 | 255 |
| TF | TF:M05553_1 | Factor: SP8; motif: WGGGCGGGTS; match class: 1 | Factor: SP8; motif: WGGGCGGGTS; match class: 1 | 1 | 0.037328 | 255 |
| TF | TF:M05493_1 | Factor: SP9; motif: NGGGCGGGTS; match class: 1 | Factor: SP9; motif: NGGGCGGGTS; match class: 1 | 1 | 0.037328 | 255 |
| TF | TF:M05360_1 | Factor: TIEG-1; motif: WGGGCGGGTG; match class: 1 | Factor: TIEG-1; motif: WGGGCGGGTG; match class: 1 | 1 | 0.037328 | 255 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0036457 | keratohyalin granule | "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope." [GOC:krc, PMID:15854042] | 1 | 0.039955 | 257 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06020_1 | Factor: ZBTB40; motif: NGGTCCTRRTCC; match class: 1 | Factor: ZBTB40; motif: NGGTCCTRRTCC; match class: 1 | 1 | 0.024886 | 258 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06037 | Factor: ZNF197; motif: NRGGCAATAAGM | Factor: ZNF197; motif: NRGGCAATAAGM | 1 | 0.024886 | 259 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-132-5p | hsa-mir-132-5p | hsa-mir-132-5p | 1 | 0.038412 | 259 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6961 | CTNNB1-GID8 complex | CTNNB1-GID8 complex | 1 | 0.049932 | 259 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0580063 | Thymus; medullary cells[High] | Thymus; medullary cells[High] | 1 | 0.018400 | 262 |
| HPA | HPA:0580823 | Thymus; cortical cells[High] | Thymus; cortical cells[High] | 1 | 0.031544 | 262 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00430 | Taurine and hypotaurine metabolism | Taurine and hypotaurine metabolism | 1 | 0.030715 | 263 |
| KEGG | KEGG:00770 | Pantothenate and CoA biosynthesis | Pantothenate and CoA biosynthesis | 1 | 0.040313 | 263 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0019449 | L-cysteine catabolic process to hypotaurine | "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine." [GOC:go_curators] | 1 | 0.049542 | 263 |
| GO:BP | GO:0019452 | L-cysteine catabolic process to taurine | "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine." [GOC:go_curators] | 1 | 0.049542 | 263 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004068 | aspartate 1-decarboxylase activity | "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11] | 1 | 0.049891 | 263 |
| GO:MF | GO:0004782 | sulfinoalanine decarboxylase activity | "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29] | 1 | 0.049891 | 263 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M04113 | Factor: GMEB2; motif: WACGTAACCACGTA | Factor: GMEB2; motif: WACGTAACCACGTA | 1 | 0.049771 | 264 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0021768 | nucleus accumbens development | "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] | 1 | 0.049542 | 269 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-8985801 | Regulation of cortical dendrite branching | Regulation of cortical dendrite branching | 1 | 0.049932 | 271 |
| REAC | REAC:R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | SLIT2:ROBO1 increases RHOA activity | 1 | 0.049932 | 271 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011679 | Tetralogy of Fallot with pulmonary stenosis | The commonest form of tetralogy of Fallot characterized by pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy, without pulmonary atresia, absent pulmonary valve, atrioventricular canal defect or absent subarterial conus. | 1 | 0.049962 | 271 |
| HP | HP:0034976 | Absent pituitary stalk | A developmental defect characterized by failure to develop of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 271 |
| HP | HP:0034977 | Abnormal pituitary stalk morphology | A structural anomaly of the pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 271 |
| HP | HP:0034978 | Interrupted pituitary stalk | A developmental defect characterized by a discontinuity of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 271 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4793954 | Defective MOGS causes CDG-2b | Defective MOGS causes CDG-2b | 1 | 0.012483 | 272 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004573 | Glc3Man9GlcNAc2 oligosaccharide glucosidase activity | "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106] | 1 | 0.024946 | 272 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:6000576 | Reduced tissue mannosyl-oligosaccharide glucosidase activity | Activity of mannosyl-oligosaccharide glucosidase (MOGS) in tissues below the lower limit of normal. MOGS activity can be measured in multiple tissues including liver and cultured fibroblasts. | 1 | 0.049962 | 272 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12064_1 | Factor: REX-1; motif: NGGCNGCCATMTTGN; match class: 1 | Factor: REX-1; motif: NGGCNGCCATMTTGN; match class: 1 | 1 | 0.012443 | 277 |
| TF | TF:M12309_1 | Factor: ZNF597; motif: GGCGGCCATYTTGN; match class: 1 | Factor: ZNF597; motif: GGCGGCCATYTTGN; match class: 1 | 1 | 0.024886 | 277 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1250-5p | hsa-mir-1250-5p | hsa-mir-1250-5p | 1 | 0.029374 | 277 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0032090 | Pyrin domain binding | "Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain." [GOC:rl] | 1 | 0.049891 | 281 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003979 | UDP-glucose 6-dehydrogenase activity | "Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23596] | 1 | 0.024946 | 282 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | Formation of the active cofactor, UDP-glucuronate | 1 | 0.037449 | 282 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006065 | UDP-glucuronate biosynthetic process | "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] | 1 | 0.049542 | 282 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1903775 | regulation of DNA double-strand break processing | "Any process that modulates the frequency, rate or extent of DNA double-strand break processing." [GO_REF:0000058, GOC:TermGenie, PMID:25203555] | 1 | 0.049542 | 285 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0140454 | protein aggregate center assembly | "The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding." [PMID:32075773] | 1 | 0.049542 | 287 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0060377 | negative regulation of mast cell differentiation | "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] | 1 | 0.049542 | 290 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0043159 | acrosomal matrix | "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729] | 1 | 0.039955 | 293 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002077 | acrosome matrix dispersal | "The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane." [GOC:dph, PMID:3886029] | 1 | 0.049542 | 293 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00061 | Fatty acid biosynthesis | Fatty acid biosynthesis | 1 | 0.034554 | 294 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-3858516 | Glycogen storage disease type 0 (liver GYS2) | Glycogen storage disease type 0 (liver GYS2) | 1 | 0.024966 | 295 |
| REAC | REAC:R-HSA-3878781 | Glycogen storage disease type IV (GBE1) | Glycogen storage disease type IV (GBE1) | 1 | 0.037449 | 295 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0061547 | glycogen synthase activity, transferring glucose-1-phosphate | "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate." [GOC:dph, PMID:21356517] | 1 | 0.049891 | 295 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0170047 | virus-like capsid | "A protein coat that surrounds nucleic acid to form a structure similar to a virus capsid. Virus-like capsids are non-infectious and are encoded by endogenous (non-viral) genes. Fly and tetrapod Arc (ancestrally-related to retrotransposon Gag) are examples of proteins that can self-assemble into capsid-like structures which encapsulate Arc mRNA and mediate the intercellular transmission of RNA." [PMID:29328916] | 1 | 0.009989 | 300 |
| GO:CC | GO:0071598 | neuronal ribonucleoprotein granule | "A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli." [GOC:BHF, GOC:go_curators, GOC:mah, PMID:19015237, PMID:20368989] | 1 | 0.049943 | 300 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-8074 | hsa-mir-8074 | hsa-mir-8074 | 1 | 0.033893 | 300 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1247-5p | hsa-mir-1247-5p | hsa-mir-1247-5p | 1 | 0.042931 | 303 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005851 | eukaryotic translation initiation factor 2B complex | "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] | 1 | 0.049943 | 303 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:6000447 | Decreased CSF asialotransferrin to transferrin ratio | The concentration of asialotransferrin relative to that of transferrin in the cerebrospinal fluid (CSF) is below the lower limit of normal. | 1 | 0.049962 | 303 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11925 | Factor: POU3F1; motif: NTAATGAKATGCGN | Factor: POU3F1; motif: NTAATGAKATGCGN | 1 | 0.012443 | 306 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0260152 | Hypothalamus; synapses[≥Medium] | Hypothalamus; synapses[≥Medium] | 1 | 0.026286 | 308 |
| HPA | HPA:0260151 | Hypothalamus; synapses[≥Low] | Hypothalamus; synapses[≥Low] | 1 | 0.031544 | 308 |
| HPA | HPA:0260143 | Hypothalamus; neuronal projections[High] | Hypothalamus; neuronal projections[High] | 1 | 0.042058 | 308 |
| HPA | HPA:0020063 | Adrenal gland; medullary cells[High] | Adrenal gland; medullary cells[High] | 1 | 0.049944 | 308 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0032812 | positive regulation of epinephrine secretion | "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] | 1 | 0.049542 | 308 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0036143 | kringle domain binding | "Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors." [GOC:yaf, Wikipedia:Kringle_domain] | 1 | 0.024946 | 311 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-668-5p | hsa-mir-668-5p | hsa-mir-668-5p | 1 | 0.040671 | 316 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000938 | GARP complex | "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664] | 1 | 0.049943 | 316 |
| GO:CC | GO:1990745 | EARP complex | "A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061] | 1 | 0.049943 | 316 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-7706 | hsa-mir-7706 | hsa-mir-7706 | 1 | 0.020336 | 317 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1537-3p | hsa-mir-1537-3p | hsa-mir-1537-3p | 1 | 0.033893 | 318 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6524 | DZIP1-GLI3 complex | DZIP1-GLI3 complex | 1 | 0.024966 | 320 |
| CORUM | CORUM:6531 | CEP164-DZIP1 complex | CEP164-DZIP1 complex | 1 | 0.049932 | 320 |
| CORUM | CORUM:6533 | DZIP1-IFT88 complex | DZIP1-IFT88 complex | 1 | 0.049932 | 320 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0062063 | BBSome binding | "Binding to a BBSome complex." [PMID:20603001] | 1 | 0.049891 | 320 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004309 | exopolyphosphatase activity | "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11] | 1 | 0.024946 | 321 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:758 | Prune/Nm23-H1 complex | Prune/Nm23-H1 complex | 1 | 0.024966 | 321 |
| CORUM | CORUM:756 | Prune-Gelsolin complex | Prune-Gelsolin complex | 1 | 0.049932 | 321 |
| CORUM | CORUM:757 | Prune-GSK3beta complex | Prune-GSK3beta complex | 1 | 0.049932 | 321 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008894 | guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity | "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40] | 1 | 0.024946 | 322 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0005151 | interleukin-1, type II receptor binding | "Binding to a Type II interleukin-1 receptor." [GOC:ai] | 1 | 0.049891 | 323 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5370 | ERAP1-ERAP2 complex | ERAP1-ERAP2 complex | 1 | 0.049932 | 323 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7363 | EYA1-SIX1 complex | EYA1-SIX1 complex | 1 | 0.049932 | 325 |
| CORUM | CORUM:7364 | EYA1-SIX2 complex | EYA1-SIX2 complex | 1 | 0.049932 | 325 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5609977 | Defective GALE causes EDG | Defective GALE causes EDG | 1 | 0.012483 | 327 |
| REAC | REAC:R-HSA-70370 | Galactose catabolism | Galactose catabolism | 1 | 0.049932 | 327 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity | "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7] | 1 | 0.024946 | 327 |
| GO:MF | GO:0003978 | UDP-glucose 4-epimerase activity | "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] | 1 | 0.024946 | 327 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05890 | Factor: NRIF; motif: NTGGGCAWACGA | Factor: NRIF; motif: NTGGGCAWACGA | 1 | 0.049771 | 327 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0006346 | Screwdriver-shaped incisors | An abnormality of morphology of the incisor tooth in which the tooth is shaped like a screwdriver blade, i.e., having a rhomboid shape. | 1 | 0.049962 | 331 |
| HP | HP:0011092 | Mulberry molar | Mulberry molars are irregular teeth generally affecting the first molars and are characterized by a grossly deformed crown imitating, as the name implies, the surface of a mulberry. | 1 | 0.049962 | 331 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3151 | Sulphiredoxin-peroxiredoxin complex | Sulphiredoxin-peroxiredoxin complex | 1 | 0.049932 | 332 |
| CORUM | CORUM:6675 | PI4K2A-PRDX1 complex | PI4K2A-PRDX1 complex | 1 | 0.049932 | 332 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0035375 | zymogen binding | "Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis." [ISBN:0198506732] | 1 | 0.024946 | 333 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016603 | glutaminyl-peptide cyclotransferase activity | "Catalysis of the reaction: N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4+." [RHEA:23652] | 1 | 0.049891 | 334 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06467 | Factor: ZNF695; motif: NTGTYCATCATT | Factor: ZNF695; motif: NTGTYCATCATT | 1 | 0.037328 | 335 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06267 | Factor: ZNF805; motif: NGGTAGGKCGTT | Factor: ZNF805; motif: NGGTAGGKCGTT | 1 | 0.049771 | 337 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 138 | 4.846490e-34 | 0 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 72 | 1.126667e-30 | 0 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 74 | 5.640708e-30 | 0 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 105 | 1.059426e-28 | 0 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 109 | 1.113018e-28 | 0 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 67 | 1.484693e-28 | 0 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 113 | 1.667159e-28 | 0 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 105 | 1.727780e-28 | 0 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 67 | 3.132244e-28 | 0 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 102 | 8.627662e-28 | 0 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 106 | 2.122144e-27 | 0 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 105 | 3.596738e-27 | 0 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 130 | 6.627037e-26 | 0 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 78 | 4.365104e-25 | 0 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 131 | 5.801710e-25 | 0 |
| GO:BP | GO:0016055 | Wnt signaling pathway | "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397] | 41 | 1.182125e-24 | 0 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 99 | 1.201737e-24 | 0 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 62 | 1.354925e-24 | 0 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 143 | 2.793776e-24 | 0 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 88 | 3.452868e-24 | 0 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 86 | 4.062825e-24 | 0 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 95 | 4.300528e-24 | 0 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 137 | 4.379839e-24 | 0 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 73 | 4.711902e-24 | 0 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 70 | 9.551135e-24 | 0 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 70 | 1.025099e-23 | 0 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 87 | 2.758183e-23 | 0 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 128 | 4.014722e-23 | 0 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 124 | 1.461941e-22 | 0 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 84 | 1.751705e-22 | 0 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 125 | 2.149757e-22 | 0 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 52 | 3.302300e-22 | 0 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 80 | 3.370629e-21 | 0 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 130 | 4.169136e-21 | 0 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 126 | 5.288781e-21 | 0 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 84 | 8.629569e-21 | 0 |
| GO:BP | GO:0045595 | regulation of cell differentiation | "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] | 63 | 4.395319e-20 | 0 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 84 | 4.507464e-20 | 0 |
| GO:BP | GO:0030154 | cell differentiation | "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] | 106 | 1.209507e-19 | 0 |
| GO:BP | GO:0048869 | cellular developmental process | "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] | 106 | 1.232041e-19 | 0 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] | 32 | 1.278034e-19 | 0 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488] | 31 | 2.534222e-19 | 0 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 99 | 6.809353e-19 | 0 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 63 | 1.280653e-18 | 0 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 123 | 1.294183e-18 | 0 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 129 | 1.533898e-18 | 0 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 176 | 1.285231e-17 | 0 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 80 | 2.228604e-17 | 0 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 83 | 2.949544e-17 | 0 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] | 27 | 3.409753e-17 | 0 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 151 | 3.702382e-17 | 0 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 89 | 4.755156e-17 | 0 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 89 | 5.559685e-17 | 0 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 56 | 7.551504e-17 | 0 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 56 | 7.800709e-17 | 0 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 177 | 2.531089e-16 | 0 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 125 | 2.699383e-16 | 0 |
| GO:BP | GO:0007165 | signal transduction | "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] | 119 | 2.963937e-16 | 0 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 53 | 3.465785e-16 | 0 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 124 | 6.922848e-16 | 0 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] | 76 | 7.332016e-16 | 0 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 133 | 7.565857e-16 | 0 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 62 | 1.023570e-15 | 0 |
| GO:BP | GO:0051093 | negative regulation of developmental process | "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 44 | 1.190600e-15 | 0 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 55 | 2.680970e-15 | 0 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 178 | 5.346428e-15 | 0 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 37 | 9.506811e-15 | 0 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 63 | 2.054944e-14 | 0 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 79 | 2.212608e-14 | 0 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 77 | 3.222817e-14 | 0 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 59 | 5.180762e-13 | 0 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 98 | 5.683524e-13 | 0 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 16 | 6.158258e-13 | 0 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 88 | 7.276453e-13 | 0 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 15 | 1.020281e-12 | 0 |
| GO:BP | GO:0061614 | miRNA transcription | "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] | 15 | 1.256543e-12 | 0 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 59 | 2.300170e-12 | 0 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 59 | 2.519251e-12 | 0 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 14 | 2.661728e-12 | 0 |
| GO:BP | GO:0072359 | circulatory system development | "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] | 44 | 3.190911e-12 | 0 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 72 | 4.317132e-12 | 0 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 57 | 6.933392e-12 | 0 |
| GO:BP | GO:0010586 | miRNA metabolic process | "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] | 16 | 9.251621e-12 | 0 |
| GO:BP | GO:0051094 | positive regulation of developmental process | "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 47 | 9.858969e-12 | 0 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 13 | 1.259724e-11 | 0 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 41 | 1.439484e-11 | 0 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 63 | 1.527008e-11 | 0 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 52 | 2.778903e-11 | 0 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] | 33 | 4.749958e-11 | 0 |
| GO:BP | GO:0060429 | epithelium development | "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] | 44 | 5.131151e-11 | 0 |
| GO:BP | GO:0048732 | gland development | "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] | 27 | 7.387653e-11 | 0 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 48 | 1.055516e-10 | 0 |
| GO:BP | GO:0043009 | chordate embryonic development | "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] | 32 | 1.225527e-10 | 0 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] | 18 | 1.240131e-10 | 0 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 51 | 1.661556e-10 | 0 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 47 | 2.278558e-10 | 0 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 36 | 2.288494e-10 | 0 |
| GO:BP | GO:0044093 | positive regulation of molecular function | "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 36 | 3.208923e-10 | 0 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 39 | 3.681882e-10 | 0 |
| GO:BP | GO:0035295 | tube development | "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] | 40 | 4.738070e-10 | 0 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 39 | 4.827970e-10 | 0 |
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb] | 16 | 6.424433e-10 | 0 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 36 | 6.425259e-10 | 0 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 47 | 6.679172e-10 | 0 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 83 | 1.170187e-09 | 0 |
| GO:BP | GO:0044092 | negative regulation of molecular function | "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 28 | 1.251019e-09 | 0 |
| GO:BP | GO:0051090 | regulation of DNA-binding transcription factor activity | "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] | 22 | 1.260310e-09 | 0 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 38 | 1.301461e-09 | 0 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] | 45 | 1.340748e-09 | 0 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 35 | 1.395036e-09 | 0 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] | 41 | 1.617437e-09 | 0 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] | 68 | 2.250038e-09 | 0 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] | 41 | 3.057629e-09 | 0 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 54 | 3.389289e-09 | 0 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 53 | 3.574191e-09 | 0 |
| GO:BP | GO:0032501 | multicellular organismal process | "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] | 119 | 3.732175e-09 | 0 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 51 | 3.924550e-09 | 0 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 90 | 4.184929e-09 | 0 |
| GO:BP | GO:0009790 | embryo development | "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] | 39 | 5.567411e-09 | 0 |
| GO:BP | GO:0033993 | response to lipid | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] | 35 | 6.925161e-09 | 0 |
| GO:BP | GO:0010647 | positive regulation of cell communication | "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 50 | 7.002618e-09 | 0 |
| GO:BP | GO:0023056 | positive regulation of signaling | "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 50 | 7.147851e-09 | 0 |
| GO:BP | GO:0007507 | heart development | "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] | 28 | 1.075290e-08 | 0 |
| GO:BP | GO:0030177 | positive regulation of Wnt signaling pathway | "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] | 15 | 1.732544e-08 | 0 |
| GO:BP | GO:0030097 | hemopoiesis | "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] | 35 | 2.672105e-08 | 0 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 55 | 2.672729e-08 | 0 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 34 | 3.055145e-08 | 0 |
| GO:BP | GO:0035239 | tube morphogenesis | "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] | 33 | 3.323478e-08 | 0 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 78 | 3.535109e-08 | 0 |
| GO:BP | GO:0009887 | animal organ morphogenesis | "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544] | 36 | 3.761799e-08 | 0 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 64 | 3.820404e-08 | 0 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 39 | 4.068961e-08 | 0 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] | 45 | 5.063578e-08 | 0 |
| GO:BP | GO:0048863 | stem cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] | 18 | 5.199982e-08 | 0 |
| GO:BP | GO:0034097 | response to cytokine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] | 34 | 5.284399e-08 | 0 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] | 14 | 6.140275e-08 | 0 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 38 | 7.908720e-08 | 0 |
| GO:BP | GO:1901652 | response to peptide | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] | 34 | 8.062415e-08 | 0 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 42 | 8.093549e-08 | 0 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 111 | 9.291871e-08 | 0 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 110 | 9.607437e-08 | 0 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 113 | 1.056575e-07 | 0 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 162 | 1.069995e-07 | 0 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 60 | 1.359497e-07 | 0 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 108 | 2.063613e-07 | 0 |
| GO:BP | GO:0001649 | osteoblast differentiation | "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid] | 17 | 2.250838e-07 | 0 |
| GO:BP | GO:0048511 | rhythmic process | "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] | 19 | 2.474622e-07 | 0 |
| GO:BP | GO:0061061 | muscle structure development | "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] | 28 | 2.539097e-07 | 0 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 32 | 3.397133e-07 | 0 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 121 | 3.835780e-07 | 0 |
| GO:BP | GO:0048729 | tissue morphogenesis | "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] | 26 | 4.523909e-07 | 0 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] | 35 | 5.041327e-07 | 0 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 115 | 5.141553e-07 | 0 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 64 | 5.577544e-07 | 0 |
| GO:BP | GO:0060767 | epithelial cell proliferation involved in prostate gland development | "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph] | 6 | 6.000114e-07 | 0 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 27 | 7.454010e-07 | 0 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 20 | 9.258763e-07 | 0 |
| GO:BP | GO:0002521 | leukocyte differentiation | "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] | 26 | 9.599541e-07 | 0 |
| GO:BP | GO:0001701 | in utero embryonic development | "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] | 21 | 1.065206e-06 | 0 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 21 | 1.112803e-06 | 0 |
| GO:BP | GO:0060284 | regulation of cell development | "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] | 30 | 1.231030e-06 | 0 |
| GO:BP | GO:0071345 | cellular response to cytokine stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah] | 30 | 1.494351e-06 | 0 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 25 | 1.764460e-06 | 0 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 38 | 1.848585e-06 | 0 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 34 | 1.994659e-06 | 0 |
| GO:BP | GO:0001503 | ossification | "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] | 21 | 2.201611e-06 | 0 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 26 | 2.240058e-06 | 0 |
| GO:BP | GO:0048589 | developmental growth | "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] | 26 | 2.312283e-06 | 0 |
| GO:BP | GO:0002682 | regulation of immune system process | "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] | 42 | 2.330681e-06 | 0 |
| GO:BP | GO:0007389 | pattern specification process | "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] | 22 | 2.513934e-06 | 0 |
| GO:BP | GO:0040007 | growth | "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] | 31 | 2.601985e-06 | 0 |
| GO:BP | GO:0006468 | protein phosphorylation | "The process of introducing a phosphate group on to a protein." [GOC:hb] | 36 | 3.332205e-06 | 0 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 156 | 3.750513e-06 | 0 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 54 | 4.087546e-06 | 0 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 19 | 4.170793e-06 | 0 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 31 | 5.143418e-06 | 0 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 31 | 5.272228e-06 | 0 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 23 | 5.290559e-06 | 0 |
| GO:BP | GO:0051338 | regulation of transferase activity | "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] | 22 | 5.560532e-06 | 0 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] | 22 | 6.676108e-06 | 0 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194] | 31 | 7.248781e-06 | 0 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 38 | 7.257390e-06 | 0 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] | 26 | 8.557323e-06 | 0 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] | 42 | 1.115982e-05 | 0 |
| GO:BP | GO:0003007 | heart morphogenesis | "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] | 16 | 1.242897e-05 | 0 |
| GO:BP | GO:0090263 | positive regulation of canonical Wnt signaling pathway | "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] | 11 | 1.257651e-05 | 0 |
| GO:BP | GO:0051091 | positive regulation of DNA-binding transcription factor activity | "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] | 14 | 1.280271e-05 | 0 |
| GO:BP | GO:0035282 | segmentation | "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689] | 11 | 1.388625e-05 | 0 |
| GO:BP | GO:0042325 | regulation of phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] | 28 | 1.407013e-05 | 0 |
| GO:BP | GO:0051148 | negative regulation of muscle cell differentiation | "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] | 9 | 1.411215e-05 | 0 |
| GO:BP | GO:0003002 | regionalization | "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] | 20 | 1.437463e-05 | 0 |
| GO:BP | GO:0007399 | nervous system development | "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] | 55 | 1.629878e-05 | 0 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 24 | 1.736745e-05 | 0 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 27 | 1.836139e-05 | 0 |
| GO:BP | GO:0043434 | response to peptide hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] | 20 | 1.881854e-05 | 0 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] | 30 | 1.924083e-05 | 0 |
| GO:BP | GO:0050673 | epithelial cell proliferation | "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] | 20 | 1.954831e-05 | 0 |
| GO:BP | GO:0009607 | response to biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] | 41 | 1.981331e-05 | 0 |
| GO:BP | GO:0051145 | smooth muscle cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai] | 9 | 2.169181e-05 | 0 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 24 | 2.351494e-05 | 0 |
| GO:BP | GO:0098542 | defense response to other organism | "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] | 35 | 2.494253e-05 | 0 |
| GO:BP | GO:0009605 | response to external stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] | 52 | 2.516602e-05 | 0 |
| GO:BP | GO:0062012 | regulation of small molecule metabolic process | "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] | 17 | 2.634893e-05 | 0 |
| GO:BP | GO:0030855 | epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] | 26 | 2.640250e-05 | 0 |
| GO:BP | GO:0006952 | defense response | "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] | 44 | 2.656381e-05 | 0 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 24 | 2.729875e-05 | 0 |
| GO:BP | GO:0051707 | response to other organism | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] | 40 | 2.999376e-05 | 0 |
| GO:BP | GO:0007517 | muscle organ development | "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] | 18 | 3.080296e-05 | 0 |
| GO:BP | GO:0007623 | circadian rhythm | "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] | 14 | 3.089178e-05 | 0 |
| GO:BP | GO:0043207 | response to external biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] | 40 | 3.159684e-05 | 0 |
| GO:BP | GO:0060768 | regulation of epithelial cell proliferation involved in prostate gland development | "Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] | 5 | 3.495482e-05 | 0 |
| GO:BP | GO:0001889 | liver development | "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] | 12 | 3.560667e-05 | 0 |
| GO:BP | GO:0048568 | embryonic organ development | "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] | 20 | 4.397053e-05 | 0 |
| GO:BP | GO:0061008 | hepaticobiliary system development | "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] | 12 | 4.467121e-05 | 0 |
| GO:BP | GO:0071396 | cellular response to lipid | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] | 23 | 5.071943e-05 | 0 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 17 | 5.162631e-05 | 0 |
| GO:BP | GO:0030850 | prostate gland development | "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751] | 8 | 5.227756e-05 | 0 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 42 | 5.237139e-05 | 0 |
| GO:BP | GO:0060562 | epithelial tube morphogenesis | "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph] | 17 | 5.392319e-05 | 0 |
| GO:BP | GO:0045670 | regulation of osteoclast differentiation | "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] | 9 | 5.450421e-05 | 0 |
| GO:BP | GO:0048663 | neuron fate commitment | "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph] | 9 | 6.165651e-05 | 0 |
| GO:BP | GO:0048598 | embryonic morphogenesis | "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu] | 23 | 6.241924e-05 | 0 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] | 26 | 6.305521e-05 | 0 |
| GO:BP | GO:0022008 | neurogenesis | "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] | 42 | 6.348910e-05 | 0 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 127 | 6.937966e-05 | 0 |
| GO:BP | GO:0060537 | muscle tissue development | "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph] | 19 | 7.024151e-05 | 0 |
| GO:BP | GO:0043549 | regulation of kinase activity | "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] | 19 | 7.286761e-05 | 0 |
| GO:BP | GO:0002376 | immune system process | "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] | 57 | 7.301844e-05 | 0 |
| GO:BP | GO:0009952 | anterior/posterior pattern specification | "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] | 14 | 7.375011e-05 | 0 |
| GO:BP | GO:0003170 | heart valve development | "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart] | 9 | 7.845617e-05 | 0 |
| GO:BP | GO:1901698 | response to nitrogen compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 31 | 8.625431e-05 | 0 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 40 | 9.895184e-05 | 0 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 23 | 1.020434e-04 | 0 |
| GO:BP | GO:0000165 | MAPK cascade | "An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267] | 25 | 1.040996e-04 | 0 |
| GO:BP | GO:0002237 | response to molecule of bacterial origin | "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm] | 17 | 1.298716e-04 | 0 |
| GO:BP | GO:0045859 | regulation of protein kinase activity | "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] | 18 | 1.336333e-04 | 0 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 21 | 1.400833e-04 | 0 |
| GO:BP | GO:0048565 | digestive tract development | "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] | 11 | 1.437797e-04 | 0 |
| GO:BP | GO:0042692 | muscle cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] | 18 | 1.494060e-04 | 0 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 130 | 1.524713e-04 | 0 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 14 | 1.564854e-04 | 0 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb] | 16 | 1.645022e-04 | 0 |
| GO:BP | GO:0001944 | vasculature development | "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] | 25 | 1.645114e-04 | 0 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] | 14 | 1.647909e-04 | 0 |
| GO:BP | GO:0014706 | striated muscle tissue development | "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle] | 18 | 1.668681e-04 | 0 |
| GO:BP | GO:0045444 | fat cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators] | 14 | 1.734925e-04 | 0 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] | 21 | 1.788351e-04 | 0 |
| GO:BP | GO:0016567 | protein ubiquitination | "The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419] | 25 | 1.909999e-04 | 0 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 14 | 2.021453e-04 | 0 |
| GO:BP | GO:0071356 | cellular response to tumor necrosis factor | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] | 13 | 2.167072e-04 | 0 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 139 | 2.274941e-04 | 0 |
| GO:BP | GO:0045732 | positive regulation of protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] | 13 | 2.291522e-04 | 0 |
| GO:BP | GO:0070848 | response to growth factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah] | 24 | 2.333729e-04 | 0 |
| GO:BP | GO:0031669 | cellular response to nutrient levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 14 | 2.469834e-04 | 0 |
| GO:BP | GO:0002683 | negative regulation of immune system process | "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] | 20 | 2.495043e-04 | 0 |
| GO:BP | GO:1902105 | regulation of leukocyte differentiation | "Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] | 16 | 2.503996e-04 | 0 |
| GO:BP | GO:0009617 | response to bacterium | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] | 24 | 2.786419e-04 | 0 |
| GO:BP | GO:0009267 | cellular response to starvation | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] | 12 | 2.786761e-04 | 0 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 37 | 2.968786e-04 | 0 |
| GO:BP | GO:0071216 | cellular response to biotic stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah] | 14 | 3.006095e-04 | 0 |
| GO:BP | GO:1903706 | regulation of hemopoiesis | "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] | 18 | 3.063743e-04 | 0 |
| GO:BP | GO:0043086 | negative regulation of catalytic activity | "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] | 15 | 3.110292e-04 | 0 |
| GO:BP | GO:0055123 | digestive system development | "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid] | 11 | 3.206851e-04 | 0 |
| GO:BP | GO:0032496 | response to lipopolysaccharide | "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464] | 16 | 3.606764e-04 | 0 |
| GO:BP | GO:0045165 | cell fate commitment | "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185] | 15 | 3.704410e-04 | 0 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] | 26 | 3.745349e-04 | 0 |
| GO:BP | GO:0042594 | response to starvation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] | 13 | 3.938263e-04 | 0 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah] | 23 | 4.144190e-04 | 0 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 168 | 4.292434e-04 | 0 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906] | 20 | 4.451125e-04 | 0 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] | 22 | 4.464815e-04 | 0 |
| GO:BP | GO:0001756 | somitogenesis | "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] | 8 | 4.695516e-04 | 0 |
| GO:BP | GO:0001890 | placenta development | "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] | 11 | 4.825209e-04 | 0 |
| GO:BP | GO:0033173 | calcineurin-NFAT signaling cascade | "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+)." [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679] | 7 | 4.912465e-04 | 0 |
| GO:BP | GO:0001655 | urogenital system development | "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] | 8 | 5.278092e-04 | 0 |
| GO:BP | GO:0032007 | negative regulation of TOR signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah] | 8 | 5.278092e-04 | 0 |
| GO:BP | GO:0031400 | negative regulation of protein modification process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 16 | 5.335911e-04 | 0 |
| GO:BP | GO:0060541 | respiratory system development | "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph] | 13 | 5.374724e-04 | 0 |
| GO:BP | GO:0038061 | non-canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217] | 10 | 5.376559e-04 | 0 |
| GO:BP | GO:0014888 | striated muscle adaptation | "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] | 7 | 5.725458e-04 | 0 |
| GO:BP | GO:0007249 | canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217] | 15 | 5.904701e-04 | 0 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] | 14 | 6.363428e-04 | 0 |
| GO:BP | GO:0034612 | response to tumor necrosis factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] | 13 | 6.576877e-04 | 0 |
| GO:BP | GO:0045669 | positive regulation of osteoblast differentiation | "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] | 8 | 6.630941e-04 | 0 |
| GO:BP | GO:0097720 | calcineurin-mediated signaling | "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544] | 7 | 6.648762e-04 | 0 |
| GO:BP | GO:0002761 | regulation of myeloid leukocyte differentiation | "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] | 10 | 6.748903e-04 | 0 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 15 | 6.960391e-04 | 0 |
| GO:BP | GO:0030162 | regulation of proteolysis | "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] | 17 | 8.035777e-04 | 0 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] | 25 | 8.361353e-04 | 0 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 12 | 8.861677e-04 | 0 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 15 | 8.865311e-04 | 0 |
| GO:BP | GO:0009798 | axis specification | "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete] | 9 | 8.866737e-04 | 0 |
| GO:BP | GO:0030324 | lung development | "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048] | 12 | 9.354841e-04 | 0 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] | 16 | 9.359772e-04 | 0 |
| GO:BP | GO:0022612 | gland morphogenesis | "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete] | 10 | 9.724211e-04 | 0 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 43 | 9.810797e-04 | 0 |
| GO:BP | GO:0071354 | cellular response to interleukin-6 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 6 | 9.947057e-04 | 0 |
| GO:BP | GO:0061323 | cell proliferation involved in heart morphogenesis | "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart] | 5 | 1.116321e-03 | 0 |
| GO:BP | GO:2000136 | regulation of cell proliferation involved in heart morphogenesis | "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] | 5 | 1.116321e-03 | 0 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 48 | 1.123643e-03 | 0 |
| GO:BP | GO:0030323 | respiratory tube development | "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid] | 12 | 1.158046e-03 | 0 |
| GO:BP | GO:0045598 | regulation of fat cell differentiation | "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] | 10 | 1.201372e-03 | 0 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 35 | 1.282021e-03 | 0 |
| GO:BP | GO:0003205 | cardiac chamber development | "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] | 11 | 1.396207e-03 | 0 |
| GO:BP | GO:0043500 | muscle adaptation | "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] | 9 | 1.464802e-03 | 0 |
| GO:BP | GO:0042742 | defense response to bacterium | "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] | 15 | 1.526003e-03 | 0 |
| GO:BP | GO:0006954 | inflammatory response | "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732] | 25 | 1.634633e-03 | 0 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators] | 21 | 1.761219e-03 | 0 |
| GO:BP | GO:0030879 | mammary gland development | "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833] | 10 | 1.804348e-03 | 0 |
| GO:BP | GO:0031347 | regulation of defense response | "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] | 24 | 1.853158e-03 | 0 |
| GO:BP | GO:0031398 | positive regulation of protein ubiquitination | "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 9 | 1.859927e-03 | 0 |
| GO:BP | GO:0003279 | cardiac septum development | "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] | 9 | 1.859927e-03 | 0 |
| GO:BP | GO:0045637 | regulation of myeloid cell differentiation | "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] | 12 | 2.031112e-03 | 0 |
| GO:BP | GO:0046649 | lymphocyte activation | "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] | 24 | 2.065010e-03 | 0 |
| GO:BP | GO:0051150 | regulation of smooth muscle cell differentiation | "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] | 6 | 2.070747e-03 | 0 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 11 | 2.086171e-03 | 0 |
| GO:BP | GO:0030316 | osteoclast differentiation | "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749] | 9 | 2.171797e-03 | 0 |
| GO:BP | GO:0051147 | regulation of muscle cell differentiation | "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] | 10 | 2.194561e-03 | 0 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:22651914, PMID:28096268] | 15 | 2.377110e-03 | 0 |
| GO:BP | GO:0070741 | response to interleukin-6 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 6 | 2.451861e-03 | 0 |
| GO:BP | GO:0001775 | cell activation | "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators] | 29 | 2.547973e-03 | 0 |
| GO:BP | GO:0030098 | lymphocyte differentiation | "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators] | 17 | 2.589092e-03 | 0 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] | 12 | 2.592419e-03 | 0 |
| GO:BP | GO:0030099 | myeloid cell differentiation | "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149] | 17 | 2.669897e-03 | 0 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 47 | 2.672323e-03 | 0 |
| GO:BP | GO:0050776 | regulation of immune response | "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 26 | 2.696307e-03 | 0 |
| GO:BP | GO:0001708 | cell fate specification | "The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate." [GOC:go_curators] | 9 | 2.724004e-03 | 0 |
| GO:BP | GO:1901800 | positive regulation of proteasomal protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] | 9 | 2.724004e-03 | 0 |
| GO:BP | GO:0048699 | generation of neurons | "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] | 35 | 2.743465e-03 | 0 |
| GO:BP | GO:0042752 | regulation of circadian rhythm | "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] | 9 | 2.933168e-03 | 0 |
| GO:BP | GO:0061053 | somite development | "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph] | 8 | 2.989033e-03 | 0 |
| GO:BP | GO:0035148 | tube formation | "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf] | 10 | 3.200971e-03 | 0 |
| GO:BP | GO:0140546 | defense response to symbiont | "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] | 28 | 3.255839e-03 | 0 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 22 | 3.352106e-03 | 0 |
| GO:BP | GO:0010721 | negative regulation of cell development | "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] | 13 | 3.701314e-03 | 0 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 27 | 3.779795e-03 | 0 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 19 | 3.925219e-03 | 0 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 19 | 3.925219e-03 | 0 |
| GO:BP | GO:0003179 | heart valve morphogenesis | "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart] | 7 | 3.964039e-03 | 0 |
| GO:BP | GO:0016331 | morphogenesis of embryonic epithelium | "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] | 10 | 4.076701e-03 | 0 |
| GO:BP | GO:0031667 | response to nutrient levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 18 | 4.249851e-03 | 0 |
| GO:BP | GO:0001568 | blood vessel development | "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] | 22 | 4.384525e-03 | 0 |
| GO:BP | GO:0002684 | positive regulation of immune system process | "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] | 28 | 4.397615e-03 | 0 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 12 | 4.534276e-03 | 0 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] | 26 | 4.599900e-03 | 0 |
| GO:BP | GO:0007178 | cell surface receptor protein serine/threonine kinase signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] | 15 | 4.772847e-03 | 0 |
| GO:BP | GO:0072497 | mesenchymal stem cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0002452, GOC:BHF] | 4 | 4.793732e-03 | 0 |
| GO:BP | GO:0072091 | regulation of stem cell proliferation | "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] | 8 | 5.025321e-03 | 0 |
| GO:BP | GO:0030217 | T cell differentiation | "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah] | 14 | 5.028487e-03 | 0 |
| GO:BP | GO:0014898 | cardiac muscle hypertrophy in response to stress | "The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] | 5 | 5.284075e-03 | 0 |
| GO:BP | GO:0014887 | cardiac muscle adaptation | "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle] | 5 | 5.284075e-03 | 0 |
| GO:BP | GO:0003299 | muscle hypertrophy in response to stress | "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart] | 5 | 5.284075e-03 | 0 |
| GO:BP | GO:0072089 | stem cell proliferation | "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] | 9 | 5.528585e-03 | 0 |
| GO:BP | GO:1903050 | regulation of proteolysis involved in protein catabolic process | "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 12 | 5.918612e-03 | 0 |
| GO:BP | GO:0030182 | neuron differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] | 33 | 5.981795e-03 | 0 |
| GO:BP | GO:0000209 | protein polyubiquitination | "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [PMID:26906419] | 13 | 6.245443e-03 | 0 |
| GO:BP | GO:0061136 | regulation of proteasomal protein catabolic process | "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] | 11 | 6.264240e-03 | 0 |
| GO:BP | GO:0042110 | T cell activation | "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149] | 19 | 6.866556e-03 | 0 |
| GO:BP | GO:0003231 | cardiac ventricle development | "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] | 9 | 7.203773e-03 | 0 |
| GO:BP | GO:0016477 | cell migration | "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] | 34 | 7.284321e-03 | 0 |
| GO:BP | GO:0035567 | non-canonical Wnt signaling pathway | "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin." [PMID:37804416] | 7 | 7.443057e-03 | 0 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 15 | 8.055756e-03 | 0 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart] | 7 | 8.216546e-03 | 0 |
| GO:BP | GO:0071772 | response to BMP | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf] | 10 | 8.519546e-03 | 0 |
| GO:BP | GO:0071773 | cellular response to BMP stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf] | 10 | 8.519546e-03 | 0 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 14 | 8.549034e-03 | 0 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 14 | 8.549034e-03 | 0 |
| GO:BP | GO:0043433 | negative regulation of DNA-binding transcription factor activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl] | 9 | 8.730507e-03 | 0 |
| GO:BP | GO:0006606 | protein import into nucleus | "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] | 10 | 8.990775e-03 | 0 |
| GO:BP | GO:0048645 | animal organ formation | "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid] | 7 | 9.055819e-03 | 0 |
| GO:BP | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb] | 7 | 9.055819e-03 | 0 |
| GO:BP | GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 9 | 9.297539e-03 | 0 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 30 | 9.884404e-03 | 0 |
| GO:BP | GO:1901875 | positive regulation of post-translational protein modification | "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 9 | 9.895872e-03 | 0 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] | 27 | 9.949547e-03 | 0 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 28 | 1.006910e-02 | 0 |
| GO:BP | GO:0061180 | mammary gland epithelium development | "The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:yaf] | 7 | 1.094935e-02 | 0 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 10 | 1.110900e-02 | 0 |
| GO:BP | GO:0051347 | positive regulation of transferase activity | "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] | 13 | 1.142515e-02 | 0 |
| GO:BP | GO:0048762 | mesenchymal cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid] | 12 | 1.158760e-02 | 0 |
| GO:BP | GO:0001837 | epithelial to mesenchymal transition | "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] | 10 | 1.170154e-02 | 0 |
| GO:BP | GO:0051170 | import into nucleus | "The directed movement of substances into the nucleus." [GOC:ai] | 10 | 1.170154e-02 | 0 |
| GO:BP | GO:0033598 | mammary gland epithelial cell proliferation | "The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:mah] | 5 | 1.184233e-02 | 0 |
| GO:BP | GO:1905314 | semi-lunar valve development | "The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure." [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19409885] | 6 | 1.185382e-02 | 0 |
| GO:BP | GO:0140467 | integrated stress response signaling | "The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041] | 6 | 1.185382e-02 | 0 |
| GO:BP | GO:1904262 | negative regulation of TORC1 signaling | "Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275] | 6 | 1.185382e-02 | 0 |
| GO:BP | GO:0003281 | ventricular septum development | "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] | 7 | 1.201293e-02 | 0 |
| GO:BP | GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 9 | 1.263131e-02 | 0 |
| GO:BP | GO:0048870 | cell motility | "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] | 37 | 1.322362e-02 | 0 |
| GO:BP | GO:0048546 | digestive tract morphogenesis | "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131] | 6 | 1.340048e-02 | 0 |
| GO:BP | GO:0035886 | vascular associated smooth muscle cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954] | 5 | 1.419821e-02 | 0 |
| GO:BP | GO:0060487 | lung epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph] | 5 | 1.419821e-02 | 0 |
| GO:BP | GO:0060479 | lung cell differentiation | "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung] | 5 | 1.419821e-02 | 0 |
| GO:BP | GO:0007254 | JNK cascade | "A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation." [PMID:11790549, PMID:20811974, PMID:23125017] | 10 | 1.435384e-02 | 0 |
| GO:BP | GO:0006109 | regulation of carbohydrate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] | 10 | 1.435384e-02 | 0 |
| GO:BP | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 8 | 1.470107e-02 | 0 |
| GO:BP | GO:0006979 | response to oxidative stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] | 15 | 1.491112e-02 | 0 |
| GO:BP | GO:0045668 | negative regulation of osteoblast differentiation | "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] | 6 | 1.510681e-02 | 0 |
| GO:BP | GO:0021700 | developmental maturation | "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 14 | 1.555036e-02 | 0 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] | 17 | 1.568129e-02 | 0 |
| GO:BP | GO:0010660 | regulation of muscle cell apoptotic process | "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 7 | 1.573153e-02 | 0 |
| GO:BP | GO:0045321 | leukocyte activation | "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add] | 25 | 1.573474e-02 | 0 |
| GO:BP | GO:0051176 | positive regulation of sulfur metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] | 3 | 1.595102e-02 | 0 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 27 | 1.662266e-02 | 0 |
| GO:BP | GO:0045087 | innate immune response | "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] | 25 | 1.686960e-02 | 0 |
| GO:BP | GO:0035270 | endocrine system development | "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system] | 9 | 1.694008e-02 | 0 |
| GO:BP | GO:0003151 | outflow tract morphogenesis | "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] | 7 | 1.716513e-02 | 0 |
| GO:BP | GO:0019827 | stem cell population maintenance | "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437] | 10 | 1.838761e-02 | 0 |
| GO:BP | GO:0010832 | negative regulation of myotube differentiation | "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] | 4 | 1.923909e-02 | 0 |
| GO:BP | GO:0000902 | cell morphogenesis | "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] | 25 | 2.073647e-02 | 0 |
| GO:BP | GO:0062013 | positive regulation of small molecule metabolic process | "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] | 9 | 2.123831e-02 | 0 |
| GO:BP | GO:0098727 | maintenance of cell number | "Any process by which the numbers of cells of a particular type or in a tissue are maintained." [GOC:dos] | 10 | 2.228556e-02 | 0 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid] | 19 | 2.362989e-02 | 0 |
| GO:BP | GO:1901655 | cellular response to ketone | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie] | 8 | 2.367537e-02 | 0 |
| GO:BP | GO:0010611 | regulation of cardiac muscle hypertrophy | "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb] | 6 | 2.378214e-02 | 0 |
| GO:BP | GO:0062197 | cellular response to chemical stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] | 13 | 2.378498e-02 | 0 |
| GO:BP | GO:0003188 | heart valve formation | "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] | 4 | 2.545943e-02 | 0 |
| GO:BP | GO:0010657 | muscle cell apoptotic process | "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb] | 7 | 2.605997e-02 | 0 |
| GO:BP | GO:0019216 | regulation of lipid metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] | 13 | 2.627899e-02 | 0 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 17 | 2.718366e-02 | 0 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] | 11 | 2.725218e-02 | 0 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 9 | 2.789144e-02 | 0 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] | 7 | 2.823086e-02 | 0 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 19 | 2.936026e-02 | 0 |
| GO:BP | GO:0071695 | anatomical structure maturation | "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah] | 12 | 2.998174e-02 | 0 |
| GO:BP | GO:1903707 | negative regulation of hemopoiesis | "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] | 8 | 3.061446e-02 | 0 |
| GO:BP | GO:2000138 | positive regulation of cell proliferation involved in heart morphogenesis | "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] | 3 | 3.167576e-02 | 0 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] | 11 | 3.199956e-02 | 0 |
| GO:BP | GO:0014743 | regulation of muscle hypertrophy | "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] | 6 | 3.262524e-02 | 0 |
| GO:BP | GO:0043583 | ear development | "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023] | 11 | 3.329278e-02 | 0 |
| GO:BP | GO:0030509 | BMP signaling pathway | "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827] | 9 | 3.442194e-02 | 0 |
| GO:BP | GO:0060538 | skeletal muscle organ development | "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph] | 10 | 3.528075e-02 | 0 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] | 7 | 3.565887e-02 | 0 |
| GO:BP | GO:0048665 | neuron fate specification | "The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph] | 5 | 3.703786e-02 | 0 |
| GO:BP | GO:0043276 | anoikis | "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, PMID:37667281] | 5 | 3.703786e-02 | 0 |
| GO:BP | GO:0030856 | regulation of epithelial cell differentiation | "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] | 9 | 3.814749e-02 | 0 |
| GO:BP | GO:0050832 | defense response to fungus | "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] | 6 | 3.986876e-02 | 0 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] | 19 | 4.030837e-02 | 0 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 23 | 4.073610e-02 | 0 |
| GO:BP | GO:0001892 | embryonic placenta development | "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] | 7 | 4.145426e-02 | 0 |
| GO:BP | GO:0014896 | muscle hypertrophy | "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle] | 7 | 4.145426e-02 | 0 |
| GO:BP | GO:0003006 | developmental process involved in reproduction | "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] | 25 | 4.148456e-02 | 0 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 17 | 4.167740e-02 | 0 |
| GO:BP | GO:0070102 | interleukin-6-mediated signaling pathway | "The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling] | 4 | 4.216501e-02 | 0 |
| GO:BP | GO:0040008 | regulation of growth | "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] | 18 | 4.251668e-02 | 0 |
| GO:BP | GO:0001525 | angiogenesis | "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] | 17 | 4.265438e-02 | 0 |
| GO:BP | GO:0009410 | response to xenobiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:jl, GOC:krc] | 15 | 4.444519e-02 | 0 |
| GO:BP | GO:0021915 | neural tube development | "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 9 | 4.663537e-02 | 0 |
| GO:BP | GO:0051154 | negative regulation of striated muscle cell differentiation | "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] | 5 | 4.896301e-02 | 0 |
| GO:BP | GO:1901524 | regulation of mitophagy | "Any process that modulates the frequency, rate or extent of macromitophagy." [GOC:TermGenie] | 5 | 4.896301e-02 | 0 |
| GO:BP | GO:0010629 | negative regulation of gene expression | "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 34 | 4.946757e-02 | 0 |
| GO:BP | GO:0051049 | regulation of transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 33 | 4.951781e-02 | 0 |
| GO:BP | GO:0042633 | hair cycle | "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, PMID:12230507] | 8 | 4.969307e-02 | 0 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] | 8 | 4.969307e-02 | 0 |
| GO:BP | GO:0008286 | insulin receptor signaling pathway | "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] | 8 | 4.969307e-02 | 0 |
| GO:BP | GO:0042303 | molting cycle | "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732] | 8 | 4.969307e-02 | 0 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 10 | 4.993165e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 103 | 6.222398e-21 | 0 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 36 | 1.375657e-18 | 0 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 111 | 1.740171e-16 | 0 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 53 | 2.054736e-16 | 0 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 122 | 1.620290e-15 | 0 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 122 | 1.620290e-15 | 0 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 122 | 1.620290e-15 | 0 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 109 | 2.338721e-15 | 0 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 153 | 1.097482e-14 | 0 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 59 | 1.449498e-13 | 0 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 20 | 1.247968e-10 | 0 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 181 | 4.068687e-10 | 0 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 195 | 4.161080e-10 | 0 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 188 | 4.289088e-10 | 0 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 164 | 7.586168e-10 | 0 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 189 | 2.905434e-09 | 0 |
| GO:CC | GO:0030877 | beta-catenin destruction complex | "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] | 6 | 1.734478e-07 | 0 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 102 | 1.208488e-06 | 0 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 102 | 1.219203e-06 | 0 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 194 | 1.385243e-05 | 0 |
| GO:CC | GO:0017053 | transcription repressor complex | "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] | 9 | 1.675110e-05 | 0 |
| GO:CC | GO:1990909 | Wnt signalosome | "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320] | 5 | 2.624325e-05 | 0 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 27 | 7.485882e-05 | 0 |
| GO:CC | GO:0033256 | I-kappaB/NF-kappaB complex | "A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm." [GOC:bf, GOC:mah, PMID:9407099] | 3 | 1.029414e-03 | 0 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 106 | 1.096361e-03 | 0 |
| GO:CC | GO:0071159 | NF-kappaB complex | "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946] | 3 | 2.555851e-03 | 0 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 13 | 3.665499e-03 | 0 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 13 | 3.665499e-03 | 0 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 13 | 4.314135e-03 | 0 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 13 | 4.455344e-03 | 0 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 23 | 4.608220e-03 | 0 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 20 | 7.555949e-03 | 0 |
| GO:CC | GO:0071144 | heteromeric SMAD protein complex | "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] | 3 | 1.401997e-02 | 0 |
| GO:CC | GO:0071141 | SMAD protein complex | "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020] | 3 | 2.088569e-02 | 0 |
| GO:CC | GO:0031461 | cullin-RING ubiquitin ligase complex | "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] | 9 | 2.459302e-02 | 0 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 21 | 2.779848e-02 | 0 |
| GO:CC | GO:1990647 | C/EBP complex | "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121] | 2 | 2.813267e-02 | 0 |
| GO:CC | GO:0035525 | NF-kappaB p50/p65 complex | "A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584] | 2 | 2.813267e-02 | 0 |
| GO:CC | GO:0033257 | Bcl3/NF-kappaB2 complex | "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099] | 2 | 2.813267e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 72 | 1.218132e-20 | 0 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 40 | 7.384728e-19 | 0 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 72 | 1.008854e-18 | 0 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 36 | 3.663047e-18 | 0 |
| GO:MF | GO:0001216 | DNA-binding transcription activator activity | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] | 34 | 2.599245e-16 | 0 |
| GO:MF | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] | 32 | 1.199157e-14 | 0 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 49 | 1.943456e-14 | 0 |
| GO:MF | GO:0000987 | cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018] | 48 | 8.101513e-14 | 0 |
| GO:MF | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] | 51 | 8.573933e-14 | 0 |
| GO:MF | GO:0000976 | transcription cis-regulatory region binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] | 53 | 1.525059e-13 | 0 |
| GO:MF | GO:0001067 | transcription regulatory region nucleic acid binding | "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] | 53 | 1.568890e-13 | 0 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 44 | 1.708566e-13 | 0 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 56 | 1.914991e-13 | 0 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 38 | 6.413428e-13 | 0 |
| GO:MF | GO:1990837 | sequence-specific double-stranded DNA binding | "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] | 53 | 8.434445e-13 | 0 |
| GO:MF | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018] | 46 | 9.457472e-13 | 0 |
| GO:MF | GO:0003700 | DNA-binding transcription factor activity | "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] | 51 | 1.095860e-12 | 0 |
| GO:MF | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] | 49 | 3.959761e-12 | 0 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 35 | 5.112106e-12 | 0 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 68 | 7.033409e-12 | 0 |
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 25 | 9.194824e-12 | 0 |
| GO:MF | GO:0003690 | double-stranded DNA binding | "Binding to double-stranded DNA." [GOC:elh, GOC:vw] | 53 | 1.026072e-11 | 0 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 194 | 7.544051e-11 | 0 |
| GO:MF | GO:0008013 | beta-catenin binding | "Binding to a catenin beta subunit." [GOC:bf] | 14 | 2.372094e-09 | 0 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 55 | 5.614647e-08 | 0 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 26 | 8.392388e-07 | 0 |
| GO:MF | GO:0001221 | transcription coregulator binding | "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] | 12 | 1.425248e-06 | 0 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 18 | 3.050378e-06 | 0 |
| GO:MF | GO:0003712 | transcription coregulator activity | "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] | 22 | 3.169307e-06 | 0 |
| GO:MF | GO:0070411 | I-SMAD binding | "Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 6 | 3.648581e-06 | 0 |
| GO:MF | GO:0001217 | DNA-binding transcription repressor activity | "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets." [GOC:txnOH-2018] | 16 | 1.478874e-05 | 0 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 16 | 5.044134e-05 | 0 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 31 | 2.017296e-04 | 0 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 56 | 2.652665e-04 | 0 |
| GO:MF | GO:0019902 | phosphatase binding | "Binding to a phosphatase." [GOC:jl] | 12 | 3.022810e-04 | 0 |
| GO:MF | GO:0042826 | histone deacetylase binding | "Binding to histone deacetylase." [GOC:jl] | 10 | 3.417371e-04 | 0 |
| GO:MF | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] | 14 | 3.576838e-04 | 0 |
| GO:MF | GO:0046332 | SMAD binding | "Binding to a SMAD signaling protein." [GOC:ai] | 8 | 6.773033e-04 | 0 |
| GO:MF | GO:0003713 | transcription coactivator activity | "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 13 | 9.928864e-04 | 0 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 21 | 1.754441e-03 | 0 |
| GO:MF | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity | "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [GOC:mah] | 4 | 3.330193e-03 | 0 |
| GO:MF | GO:0004842 | ubiquitin-protein transferase activity | "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] | 17 | 4.942919e-03 | 0 |
| GO:MF | GO:0030234 | enzyme regulator activity | "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 31 | 7.121146e-03 | 0 |
| GO:MF | GO:0140767 | enzyme-substrate adaptor activity | "An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity." [PMID:16250895, PMID:34358446] | 7 | 7.643996e-03 | 0 |
| GO:MF | GO:0043425 | bHLH transcription factor binding | "Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] | 5 | 8.042228e-03 | 0 |
| GO:MF | GO:0097027 | ubiquitin-protein transferase activator activity | "Binds to and increases the activity of a ubiquitin-protein transferase." [GOC:rb, PMID:18321851] | 4 | 8.276043e-03 | 0 |
| GO:MF | GO:0042803 | protein homodimerization activity | "Binding to an identical protein to form a homodimer." [GOC:jl] | 21 | 9.251627e-03 | 0 |
| GO:MF | GO:0019787 | ubiquitin-like protein transferase activity | "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] | 17 | 1.067213e-02 | 0 |
| GO:MF | GO:0045309 | protein phosphorylated amino acid binding | "Binding to a phosphorylated amino acid residue within a protein." [GOC:go_curators] | 6 | 1.426321e-02 | 0 |
| GO:MF | GO:0016755 | aminoacyltransferase activity | "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] | 17 | 1.645078e-02 | 0 |
| GO:MF | GO:0016746 | acyltransferase activity | "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-] | 21 | 2.292514e-02 | 0 |
| GO:MF | GO:0017151 | DEAD/H-box RNA helicase binding | "Binding to a DEAD/H-box RNA helicase." [GOC:jl] | 3 | 2.691810e-02 | 0 |
| GO:MF | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity | "The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274] | 6 | 2.711241e-02 | 0 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 202 | 2.733057e-02 | 0 |
| GO:MF | GO:0002039 | p53 binding | "Binding to one of the p53 family of proteins." [GOC:hjd] | 6 | 3.487827e-02 | 0 |
| GO:MF | GO:0061630 | ubiquitin protein ligase activity | "Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777] | 13 | 4.025149e-02 | 0 |
| GO:MF | GO:0140693 | molecular condensate scaffold activity | "Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate." [PMID:28225081] | 5 | 4.382837e-02 | 0 |
| GO:MF | GO:0002020 | protease binding | "Binding to a protease or a peptidase." [GOC:hjd] | 8 | 4.801266e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 44 | 3.003748e-20 | 0 |
| KEGG | KEGG:04310 | Wnt signaling pathway | Wnt signaling pathway | 24 | 4.493506e-15 | 0 |
| KEGG | KEGG:05224 | Breast cancer | Breast cancer | 21 | 2.379901e-13 | 0 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 21 | 2.739907e-13 | 0 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 21 | 2.901817e-12 | 0 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 27 | 2.320360e-11 | 0 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 18 | 8.130988e-10 | 0 |
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 18 | 1.265690e-09 | 0 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 20 | 5.310630e-09 | 0 |
| KEGG | KEGG:05217 | Basal cell carcinoma | Basal cell carcinoma | 12 | 9.427847e-09 | 0 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 17 | 9.980350e-09 | 0 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 14 | 1.211561e-08 | 0 |
| KEGG | KEGG:04668 | TNF signaling pathway | TNF signaling pathway | 14 | 9.713538e-08 | 0 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | Thyroid hormone signaling pathway | 14 | 2.424338e-07 | 0 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 18 | 4.199101e-07 | 0 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 13 | 2.075729e-06 | 0 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 16 | 2.392753e-06 | 0 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | C-type lectin receptor signaling pathway | 12 | 3.638092e-06 | 0 |
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 12 | 5.579701e-06 | 0 |
| KEGG | KEGG:04380 | Osteoclast differentiation | Osteoclast differentiation | 13 | 6.560803e-06 | 0 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | Adipocytokine signaling pathway | 10 | 6.614433e-06 | 0 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | Th1 and Th2 cell differentiation | 11 | 6.694275e-06 | 0 |
| KEGG | KEGG:04211 | Longevity regulating pathway | Longevity regulating pathway | 11 | 6.694275e-06 | 0 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 11 | 9.486425e-06 | 0 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 14 | 1.053883e-05 | 0 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | Transcriptional misregulation in cancer | 15 | 1.380308e-05 | 0 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | Signaling pathways regulating pluripotency of stem cells | 13 | 1.696429e-05 | 0 |
| KEGG | KEGG:04916 | Melanogenesis | Melanogenesis | 11 | 2.503379e-05 | 0 |
| KEGG | KEGG:04150 | mTOR signaling pathway | mTOR signaling pathway | 13 | 4.345618e-05 | 0 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 10 | 4.823956e-05 | 0 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | IL-17 signaling pathway | 10 | 9.106904e-05 | 0 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 19 | 1.118971e-04 | 0 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 10 | 1.228804e-04 | 0 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 14 | 1.236607e-04 | 0 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 14 | 1.480212e-04 | 0 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 9 | 1.565032e-04 | 0 |
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 8 | 1.863431e-04 | 0 |
| KEGG | KEGG:04330 | Notch signaling pathway | Notch signaling pathway | 8 | 2.425881e-04 | 0 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | Chemical carcinogenesis - receptor activation | 14 | 2.632690e-04 | 0 |
| KEGG | KEGG:04659 | Th17 cell differentiation | Th17 cell differentiation | 10 | 3.092137e-04 | 0 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 19 | 3.190448e-04 | 0 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | Acute myeloid leukemia | 8 | 5.665311e-04 | 0 |
| KEGG | KEGG:04710 | Circadian rhythm | Circadian rhythm | 6 | 8.589212e-04 | 0 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 8 | 1.463462e-03 | 0 |
| KEGG | KEGG:04340 | Hedgehog signaling pathway | Hedgehog signaling pathway | 7 | 1.621289e-03 | 0 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 11 | 2.059637e-03 | 0 |
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 10 | 2.226924e-03 | 0 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | B cell receptor signaling pathway | 8 | 2.345121e-03 | 0 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | Glucagon signaling pathway | 9 | 2.667217e-03 | 0 |
| KEGG | KEGG:04910 | Insulin signaling pathway | Insulin signaling pathway | 10 | 3.282458e-03 | 0 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | MicroRNAs in cancer | 15 | 5.105890e-03 | 0 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | Lipid and atherosclerosis | 12 | 7.363989e-03 | 0 |
| KEGG | KEGG:05030 | Cocaine addiction | Cocaine addiction | 6 | 7.433214e-03 | 0 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | AGE-RAGE signaling pathway in diabetic complications | 8 | 1.070222e-02 | 0 |
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | NF-kappa B signaling pathway | 8 | 1.230125e-02 | 0 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 9 | 1.301077e-02 | 0 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 9 | 1.635935e-02 | 0 |
| KEGG | KEGG:05216 | Thyroid cancer | Thyroid cancer | 5 | 1.857836e-02 | 0 |
| KEGG | KEGG:05162 | Measles | Measles | 9 | 1.931788e-02 | 0 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 18 | 2.057801e-02 | 0 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | Ubiquitin mediated proteolysis | 9 | 2.152758e-02 | 0 |
| KEGG | KEGG:04936 | Alcoholic liver disease | Alcoholic liver disease | 9 | 2.394341e-02 | 0 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | Human immunodeficiency virus 1 infection | 11 | 2.670720e-02 | 0 |
| KEGG | KEGG:05219 | Bladder cancer | Bladder cancer | 5 | 3.044851e-02 | 0 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | PD-L1 expression and PD-1 checkpoint pathway in cancer | 7 | 3.202204e-02 | 0 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | T cell receptor signaling pathway | 8 | 3.559210e-02 | 0 |
| KEGG | KEGG:04932 | Non-alcoholic fatty liver disease | Non-alcoholic fatty liver disease | 9 | 4.364015e-02 | 0 |
| KEGG | KEGG:05031 | Amphetamine addiction | Amphetamine addiction | 6 | 4.992994e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 44 | 2.078586e-18 | 0 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 17 | 4.958928e-13 | 0 |
| WP | WP:WP4262 | Breast cancer pathway | Breast cancer pathway | 22 | 1.253678e-12 | 0 |
| WP | WP:WP2064 | Neural crest differentiation | Neural crest differentiation | 16 | 1.557151e-09 | 0 |
| WP | WP:WP710 | DNA damage response only ATM dependent | DNA damage response only ATM dependent | 15 | 5.779019e-08 | 0 |
| WP | WP:WP1984 | Integrated breast cancer pathway | Integrated breast cancer pathway | 17 | 9.837012e-08 | 0 |
| WP | WP:WP4754 | IL18 signaling | IL18 signaling | 11 | 3.109912e-07 | 0 |
| WP | WP:WP4879 | Overlap between signal transduction pathways contributing to LMNA laminopathies | Overlap between signal transduction pathways contributing to LMNA laminopathies | 11 | 3.799030e-07 | 0 |
| WP | WP:WP236 | Adipogenesis | Adipogenesis | 15 | 7.137121e-07 | 0 |
| WP | WP:WP363 | Wnt signaling NetPath | Wnt signaling NetPath | 10 | 7.797414e-07 | 0 |
| WP | WP:WP428 | Wnt signaling | Wnt signaling | 14 | 9.587280e-07 | 0 |
| WP | WP:WP4258 | lncRNA in canonical Wnt signaling and colorectal cancer | lncRNA in canonical Wnt signaling and colorectal cancer | 13 | 1.322835e-06 | 0 |
| WP | WP:WP4844 | Influence of laminopathies on Wnt signaling | Influence of laminopathies on Wnt signaling | 9 | 1.360666e-06 | 0 |
| WP | WP:WP4331 | Neovascularization processes | Neovascularization processes | 9 | 1.360666e-06 | 0 |
| WP | WP:WP2036 | TNF related weak inducer of apoptosis TWEAK signaling | TNF related weak inducer of apoptosis TWEAK signaling | 9 | 1.757830e-06 | 0 |
| WP | WP:WP5087 | Pleural mesothelioma | Pleural mesothelioma | 26 | 2.171270e-06 | 0 |
| WP | WP:WP3981 | miRNA regulation of prostate cancer signaling | miRNA regulation of prostate cancer signaling | 8 | 5.879873e-06 | 0 |
| WP | WP:WP4211 | Transcriptional cascade regulating adipogenesis | Transcriptional cascade regulating adipogenesis | 6 | 6.314336e-06 | 0 |
| WP | WP:WP4149 | White fat cell differentiation | White fat cell differentiation | 8 | 7.730053e-06 | 0 |
| WP | WP:WP4482 | Vitamin D in inflammatory diseases | Vitamin D in inflammatory diseases | 7 | 8.969819e-06 | 0 |
| WP | WP:WP3599 | Transcription factor regulation in adipogenesis | Transcription factor regulation in adipogenesis | 7 | 8.969819e-06 | 0 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 19 | 1.139349e-05 | 0 |
| WP | WP:WP5272 | LDL influence on CD14 and TLR4 | LDL influence on CD14 and TLR4 | 7 | 1.271513e-05 | 0 |
| WP | WP:WP4787 | Osteoblast differentiation and related diseases | Osteoblast differentiation and related diseases | 13 | 1.463200e-05 | 0 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 19 | 1.544484e-05 | 0 |
| WP | WP:WP5529 | Wnt Beta catenin signaling and ARTD family members | Wnt Beta catenin signaling and ARTD family members | 6 | 1.791562e-05 | 0 |
| WP | WP:WP399 | Wnt signaling and pluripotency | Wnt signaling and pluripotency | 12 | 1.834632e-05 | 0 |
| WP | WP:WP2018 | RANKL RANK signaling | RANKL RANK signaling | 9 | 2.278990e-05 | 0 |
| WP | WP:WP138 | Androgen receptor signaling | Androgen receptor signaling | 11 | 2.947030e-05 | 0 |
| WP | WP:WP61 | Notch signaling | Notch signaling | 9 | 3.253018e-05 | 0 |
| WP | WP:WP2840 | Hair follicle development cytodifferentiation stage 3 of 3 | Hair follicle development cytodifferentiation stage 3 of 3 | 11 | 3.759638e-05 | 0 |
| WP | WP:WP5144 | NRP1 triggered signaling in pancreatic cancer | NRP1 triggered signaling in pancreatic cancer | 9 | 3.863264e-05 | 0 |
| WP | WP:WP4336 | ncRNAs in Wnt signaling in hepatocellular carcinoma | ncRNAs in Wnt signaling in hepatocellular carcinoma | 11 | 4.235917e-05 | 0 |
| WP | WP:WP4872 | MAP3K1 role in promoting and blocking gonadal determination | MAP3K1 role in promoting and blocking gonadal determination | 6 | 4.309534e-05 | 0 |
| WP | WP:WP5353 | Macrophage stimulating protein MSP signaling | Macrophage stimulating protein MSP signaling | 12 | 4.345107e-05 | 0 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 10 | 6.463156e-05 | 0 |
| WP | WP:WP4659 | Gastrin signaling | Gastrin signaling | 12 | 7.899635e-05 | 0 |
| WP | WP:WP4239 | Epithelial to mesenchymal transition in colorectal cancer | Epithelial to mesenchymal transition in colorectal cancer | 14 | 8.887749e-05 | 0 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 11 | 9.352862e-05 | 0 |
| WP | WP:WP5475 | Hallmark of cancer sustaining proliferative signaling | Hallmark of cancer sustaining proliferative signaling | 11 | 1.285902e-04 | 0 |
| WP | WP:WP3414 | Initiation of transcription and translation elongation at the HIV 1 LTR | Initiation of transcription and translation elongation at the HIV 1 LTR | 7 | 1.539469e-04 | 0 |
| WP | WP:WP2112 | IL17 signaling | IL17 signaling | 7 | 1.539469e-04 | 0 |
| WP | WP:WP2571 | Polycystic kidney disease pathway | Polycystic kidney disease pathway | 10 | 2.456220e-04 | 0 |
| WP | WP:WP2034 | Leptin signaling | Leptin signaling | 9 | 5.031117e-04 | 0 |
| WP | WP:WP4746 | Thyroid hormones production and peripheral downstream signaling effects | Thyroid hormones production and peripheral downstream signaling effects | 10 | 6.324408e-04 | 0 |
| WP | WP:WP3658 | Wnt beta catenin signaling in leukemia | Wnt beta catenin signaling in leukemia | 6 | 7.082262e-04 | 0 |
| WP | WP:WP3931 | Embryonic stem cell pluripotency pathways | Embryonic stem cell pluripotency pathways | 11 | 7.595789e-04 | 0 |
| WP | WP:WP5474 | Catabolism of skeletal muscle in cachexia | Catabolism of skeletal muscle in cachexia | 7 | 7.626543e-04 | 0 |
| WP | WP:WP3664 | Regulation of Wnt B catenin signaling by small molecule compounds | Regulation of Wnt B catenin signaling by small molecule compounds | 5 | 1.323153e-03 | 0 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 8 | 1.628658e-03 | 0 |
| WP | WP:WP4155 | Endometrial cancer | Endometrial cancer | 8 | 1.839508e-03 | 0 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 8 | 2.072946e-03 | 0 |
| WP | WP:WP1541 | Energy metabolism | Energy metabolism | 7 | 2.333566e-03 | 0 |
| WP | WP:WP1591 | Heart development | Heart development | 7 | 2.333566e-03 | 0 |
| WP | WP:WP4172 | PI3K Akt signaling | PI3K Akt signaling | 18 | 2.336288e-03 | 0 |
| WP | WP:WP1403 | AMP activated protein kinase signaling | AMP activated protein kinase signaling | 8 | 2.928549e-03 | 0 |
| WP | WP:WP5098 | T cell activation SARS CoV 2 | T cell activation SARS CoV 2 | 9 | 3.034611e-03 | 0 |
| WP | WP:WP5293 | Acute myeloid leukemia | Acute myeloid leukemia | 8 | 3.272708e-03 | 0 |
| WP | WP:WP231 | TNF alpha signaling | TNF alpha signaling | 9 | 3.328605e-03 | 0 |
| WP | WP:WP2380 | Brain derived neurotrophic factor BDNF signaling | Brain derived neurotrophic factor BDNF signaling | 11 | 3.485849e-03 | 0 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 10 | 3.658205e-03 | 0 |
| WP | WP:WP3617 | Photodynamic therapy induced NF kB survival signaling | Photodynamic therapy induced NF kB survival signaling | 6 | 4.411973e-03 | 0 |
| WP | WP:WP4150 | Wnt signaling in kidney disease | Wnt signaling in kidney disease | 6 | 5.222153e-03 | 0 |
| WP | WP:WP4141 | PI3K AKT mTOR vitamin D3 signaling | PI3K AKT mTOR vitamin D3 signaling | 5 | 5.264207e-03 | 0 |
| WP | WP:WP3594 | Circadian rhythm genes | Circadian rhythm genes | 13 | 5.762150e-03 | 0 |
| WP | WP:WP2857 | Mesodermal commitment pathway | Mesodermal commitment pathway | 11 | 6.337627e-03 | 0 |
| WP | WP:WP2374 | Oncostatin M signaling | Oncostatin M signaling | 7 | 7.591903e-03 | 0 |
| WP | WP:WP3932 | Focal adhesion PI3K Akt mTOR signaling | Focal adhesion PI3K Akt mTOR signaling | 16 | 8.507830e-03 | 0 |
| WP | WP:WP4666 | Hepatitis B infection | Hepatitis B infection | 11 | 9.204773e-03 | 0 |
| WP | WP:WP615 | Senescence and autophagy in cancer | Senescence and autophagy in cancer | 9 | 1.255229e-02 | 0 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 8 | 1.296372e-02 | 0 |
| WP | WP:WP706 | Sudden infant death syndrome SIDS susceptibility pathways | Sudden infant death syndrome SIDS susceptibility pathways | 11 | 1.390229e-02 | 0 |
| WP | WP:WP5300 | TROP2 regulatory signaling | TROP2 regulatory signaling | 6 | 1.695840e-02 | 0 |
| WP | WP:WP268 | Notch signaling | Notch signaling | 6 | 1.695840e-02 | 0 |
| WP | WP:WP4874 | CAMKK2 pathway | CAMKK2 pathway | 9 | 1.807353e-02 | 0 |
| WP | WP:WP5527 | NF kB signaling and ARTD family members | NF kB signaling and ARTD family members | 5 | 1.812383e-02 | 0 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 8 | 2.149233e-02 | 0 |
| WP | WP:WP2586 | Aryl hydrocarbon receptor pathway | Aryl hydrocarbon receptor pathway | 6 | 2.189409e-02 | 0 |
| WP | WP:WP3680 | Physico chemical features and toxicity associated pathways | Physico chemical features and toxicity associated pathways | 7 | 2.218562e-02 | 0 |
| WP | WP:WP2355 | Corticotropin releasing hormone signaling | Corticotropin releasing hormone signaling | 8 | 2.724692e-02 | 0 |
| WP | WP:WP5158 | Urotensin II mediated signaling | Urotensin II mediated signaling | 7 | 2.948093e-02 | 0 |
| WP | WP:WP3858 | Toll like receptor signaling related to MyD88 | Toll like receptor signaling related to MyD88 | 5 | 3.009650e-02 | 0 |
| WP | WP:WP5477 | Molecular pathway for oxidative stress | Molecular pathway for oxidative stress | 6 | 3.137005e-02 | 0 |
| WP | WP:WP395 | IL4 signaling | IL4 signaling | 6 | 3.516308e-02 | 0 |
| WP | WP:WP5373 | Osteoarthritic chondrocyte hypertrophy | Osteoarthritic chondrocyte hypertrophy | 6 | 3.516308e-02 | 0 |
| WP | WP:WP3611 | Photodynamic therapy induced AP 1 survival signaling | Photodynamic therapy induced AP 1 survival signaling | 6 | 3.516308e-02 | 0 |
| WP | WP:WP2839 | Hair follicle development organogenesis stage 2 of 3 | Hair follicle development organogenesis stage 2 of 3 | 5 | 3.519460e-02 | 0 |
| WP | WP:WP5113 | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway | 5 | 3.519460e-02 | 0 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 9 | 3.534492e-02 | 0 |
| WP | WP:WP3286 | Copper homeostasis | Copper homeostasis | 6 | 3.930975e-02 | 0 |
| WP | WP:WP3995 | Prion disease pathway | Prion disease pathway | 5 | 4.092678e-02 | 0 |
| WP | WP:WP4341 | Non genomic actions of 1 25 dihydroxyvitamin D3 | Non genomic actions of 1 25 dihydroxyvitamin D3 | 7 | 4.587770e-02 | 0 |
| WP | WP:WP3971 | OSX and miRNAs in tooth development | OSX and miRNAs in tooth development | 5 | 4.734412e-02 | 0 |
| WP | WP:WP391 | Mitochondrial gene expression | Mitochondrial gene expression | 4 | 4.938077e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 48 | 3.950258e-08 | 0 |
| REAC | REAC:R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 9 | 1.633934e-07 | 0 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 48 | 9.716050e-07 | 0 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 51 | 1.582842e-06 | 0 |
| REAC | REAC:R-HSA-9843745 | Adipogenesis | Adipogenesis | 13 | 2.333721e-06 | 0 |
| REAC | REAC:R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | Transcriptional regulation of white adipocyte differentiation | 11 | 1.322129e-05 | 0 |
| REAC | REAC:R-HSA-201681 | TCF dependent signaling in response to WNT | TCF dependent signaling in response to WNT | 17 | 1.899333e-05 | 0 |
| REAC | REAC:R-HSA-195721 | Signaling by WNT | Signaling by WNT | 20 | 2.570476e-05 | 0 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 11 | 6.832007e-05 | 0 |
| REAC | REAC:R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | Toll Like Receptor 3 (TLR3) Cascade | 11 | 1.270410e-04 | 0 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 66 | 1.508859e-04 | 0 |
| REAC | REAC:R-HSA-166166 | MyD88-independent TLR4 cascade | MyD88-independent TLR4 cascade | 11 | 1.876776e-04 | 0 |
| REAC | REAC:R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | TRIF (TICAM1)-mediated TLR4 signaling | 11 | 1.876776e-04 | 0 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 12 | 2.942442e-04 | 0 |
| REAC | REAC:R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | Toll Like Receptor 4 (TLR4) Cascade | 12 | 5.045681e-04 | 0 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 11 | 5.047255e-04 | 0 |
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 10 | 5.131191e-04 | 0 |
| REAC | REAC:R-HSA-8853884 | Transcriptional Regulation by VENTX | Transcriptional Regulation by VENTX | 7 | 5.682874e-04 | 0 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 11 | 8.272732e-04 | 0 |
| REAC | REAC:R-HSA-9818749 | Regulation of NFE2L2 gene expression | Regulation of NFE2L2 gene expression | 4 | 1.283712e-03 | 0 |
| REAC | REAC:R-HSA-8941326 | RUNX2 regulates bone development | RUNX2 regulates bone development | 6 | 1.725014e-03 | 0 |
| REAC | REAC:R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 10 | 2.141886e-03 | 0 |
| REAC | REAC:R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | Toll Like Receptor TLR6:TLR2 Cascade | 10 | 2.141886e-03 | 0 |
| REAC | REAC:R-HSA-168898 | Toll-like Receptor Cascades | Toll-like Receptor Cascades | 12 | 2.272828e-03 | 0 |
| REAC | REAC:R-HSA-448706 | Interleukin-1 processing | Interleukin-1 processing | 4 | 2.284340e-03 | 0 |
| REAC | REAC:R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | Toll Like Receptor 2 (TLR2) Cascade | 10 | 2.724043e-03 | 0 |
| REAC | REAC:R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | Toll Like Receptor TLR1:TLR2 Cascade | 10 | 2.724043e-03 | 0 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 28 | 3.396813e-03 | 0 |
| REAC | REAC:R-HSA-975871 | MyD88 cascade initiated on plasma membrane | MyD88 cascade initiated on plasma membrane | 9 | 4.283369e-03 | 0 |
| REAC | REAC:R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | Toll Like Receptor 10 (TLR10) Cascade | 9 | 4.283369e-03 | 0 |
| REAC | REAC:R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | Toll Like Receptor 5 (TLR5) Cascade | 9 | 4.283369e-03 | 0 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 13 | 5.321881e-03 | 0 |
| REAC | REAC:R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 9 | 6.515779e-03 | 0 |
| REAC | REAC:R-HSA-975155 | MyD88 dependent cascade initiated on endosome | MyD88 dependent cascade initiated on endosome | 9 | 7.064665e-03 | 0 |
| REAC | REAC:R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | Toll Like Receptor 7/8 (TLR7/8) Cascade | 9 | 7.652456e-03 | 0 |
| REAC | REAC:R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | Downstream signaling events of B Cell Receptor (BCR) | 8 | 9.100655e-03 | 0 |
| REAC | REAC:R-HSA-5689880 | Ub-specific processing proteases | Ub-specific processing proteases | 13 | 9.172271e-03 | 0 |
| REAC | REAC:R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | Toll Like Receptor 9 (TLR9) Cascade | 9 | 9.672010e-03 | 0 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 48 | 1.072015e-02 | 0 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 19 | 1.112129e-02 | 0 |
| REAC | REAC:R-HSA-195253 | Degradation of beta-catenin by the destruction complex | Degradation of beta-catenin by the destruction complex | 8 | 1.193232e-02 | 0 |
| REAC | REAC:R-HSA-5083630 | Defective LFNG causes SCDO3 | Defective LFNG causes SCDO3 | 3 | 1.308211e-02 | 0 |
| REAC | REAC:R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | Deactivation of the beta-catenin transactivating complex | 6 | 1.318228e-02 | 0 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 15 | 1.330512e-02 | 0 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 27 | 1.391142e-02 | 0 |
| REAC | REAC:R-HSA-9616222 | Transcriptional regulation of granulopoiesis | Transcriptional regulation of granulopoiesis | 8 | 1.682459e-02 | 0 |
| REAC | REAC:R-HSA-200425 | Carnitine shuttle | Carnitine shuttle | 4 | 1.713797e-02 | 0 |
| REAC | REAC:R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 4 | 1.713797e-02 | 0 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 27 | 1.885426e-02 | 0 |
| REAC | REAC:R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 5 | 2.448654e-02 | 0 |
| REAC | REAC:R-HSA-8849470 | PTK6 Regulates Cell Cycle | PTK6 Regulates Cell Cycle | 3 | 2.588276e-02 | 0 |
| REAC | REAC:R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | Pre-NOTCH Processing in the Endoplasmic Reticulum | 3 | 2.588276e-02 | 0 |
| REAC | REAC:R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 4 | 3.045547e-02 | 0 |
| REAC | REAC:R-HSA-446652 | Interleukin-1 family signaling | Interleukin-1 family signaling | 10 | 3.155901e-02 | 0 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 8 | 3.170499e-02 | 0 |
| REAC | REAC:R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6 | 3.625880e-02 | 0 |
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 4 | 3.937390e-02 | 0 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 4 | 3.937390e-02 | 0 |
| REAC | REAC:R-HSA-196299 | Beta-catenin phosphorylation cascade | Beta-catenin phosphorylation cascade | 4 | 3.937390e-02 | 0 |
| REAC | REAC:R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | Nuclear events stimulated by ALK signaling in cancer | 5 | 4.007741e-02 | 0 |
| REAC | REAC:R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | RUNX3 regulates CDKN1A transcription | 3 | 4.480789e-02 | 0 |
| REAC | REAC:R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 3 | 4.480789e-02 | 0 |
| REAC | REAC:R-HSA-5603029 | IkBA variant leads to EDA-ID | IkBA variant leads to EDA-ID | 3 | 4.480789e-02 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0000006 | Autosomal dominant inheritance | A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. | 55 | 0.000982 | 0 |
| HP | HP:0010785 | Gonadal neoplasm | A tumor (abnormal growth of tissue) of a gonad. | 11 | 0.001178 | 0 |
| HP | HP:0010787 | Genital neoplasm | A tumor (abnormal growth of tissue) of the genital system. | 13 | 0.001554 | 0 |
| HP | HP:0001442 | Typified by somatic mosaicism | Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic. | 13 | 0.006260 | 0 |
| HP | HP:0100728 | Germ cell neoplasia | Germ cell neoplasia | 7 | 0.009590 | 0 |
| HP | HP:0006753 | Neoplasm of the stomach | A tumor (abnormal growth of tissue) of the stomach. | 9 | 0.012557 | 0 |
| HP | HP:0100526 | Neoplasm of the lung | Tumor of the lung. | 8 | 0.013007 | 0 |
| HP | HP:0010788 | Testicular neoplasm | The presence of a neoplasm of the testis. | 6 | 0.020671 | 0 |
| HP | HP:0100848 | Neoplasm of the male external genitalia | A tumor (abnormal growth of tissue) of the male external genitalia. | 6 | 0.024771 | 0 |
| HP | HP:0006562 | Viral hepatitis | Inflammation of the liver due to infection with a virus. | 4 | 0.032849 | 0 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 14 | 0.033051 | 0 |
| HP | HP:0005584 | Renal cell carcinoma | A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule. | 8 | 0.035013 | 0 |
| HP | HP:0030448 | Soft tissue sarcoma | A type of sarcoma (A connective tissue neoplasm formed by proliferation of mesodermal cells) that develops from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues. | 10 | 0.036678 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5196 | TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) | TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) | 5 | 0.001058 | 0 |
| CORUM | CORUM:6352 | FoxM1-Axin-GSK3beta complex | FoxM1-Axin-GSK3beta complex | 3 | 0.002641 | 0 |
| CORUM | CORUM:6353 | beta-Catenin destruction complex | beta-Catenin destruction complex | 3 | 0.002641 | 0 |
| CORUM | CORUM:6963 | AXIN1-GID8-GSK3B complex | AXIN1-GID8-GSK3B complex | 3 | 0.002641 | 0 |
| CORUM | CORUM:6906 | FBXW7-CDX2-GSK3B complex | FBXW7-CDX2-GSK3B complex | 3 | 0.002641 | 0 |
| CORUM | CORUM:6248 | FBXW7-CSF3R-GSK3B complex | FBXW7-CSF3R-GSK3B complex | 3 | 0.002641 | 0 |
| CORUM | CORUM:3166 | AXIN1-APC-CTNNB1-GSK3B complex | AXIN1-APC-CTNNB1-GSK3B complex | 3 | 0.002641 | 0 |
| CORUM | CORUM:2086 | NFKB1-NFKB2-RELA-RELB complex | NFKB1-NFKB2-RELA-RELB complex | 3 | 0.002641 | 0 |
| CORUM | CORUM:2706 | SMAD3-SMAD4-SP1 complex | SMAD3-SMAD4-SP1 complex | 3 | 0.002641 | 0 |
| CORUM | CORUM:2084 | NFKB1-NFKB2-REL-RELA-RELB complex | NFKB1-NFKB2-REL-RELA-RELB complex | 3 | 0.010373 | 0 |
| CORUM | CORUM:2998 | Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex | Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex | 3 | 0.010373 | 0 |
| CORUM | CORUM:7159 | TSC2-GSK3-AXIN-DVL complex | TSC2-GSK3-AXIN-DVL complex | 3 | 0.010373 | 0 |
| CORUM | CORUM:4151 | TSC (TSC1, TSC2, AXIN, GSK3) complex | TSC (TSC1, TSC2, AXIN, GSK3) complex | 3 | 0.010373 | 0 |
| CORUM | CORUM:2189 | Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) | Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) | 3 | 0.025462 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12703_1 | Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1 | Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1 | 77 | 0.002389 | 0 |
| TF | TF:M09734 | Factor: ZNF692; motif: SYNGGSCCCASCCNC | Factor: ZNF692; motif: SYNGGSCCCASCCNC | 156 | 0.003978 | 0 |
| TF | TF:M12722_1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | 103 | 0.005748 | 0 |
| TF | TF:M01100 | Factor: LRF; motif: GGGGKYNNB | Factor: LRF; motif: GGGGKYNNB | 113 | 0.005841 | 0 |
| TF | TF:M00695_1 | Factor: ETF; motif: GVGGMGG; match class: 1 | Factor: ETF; motif: GVGGMGG; match class: 1 | 107 | 0.006698 | 0 |
| TF | TF:M01219 | Factor: SP1:SP3; motif: CCSCCCCCYCC | Factor: SP1:SP3; motif: CCSCCCCCYCC | 104 | 0.010087 | 0 |
| TF | TF:M01972 | Factor: EGR-1; motif: TGCGTGGGCGK | Factor: EGR-1; motif: TGCGTGGGCGK | 87 | 0.012077 | 0 |
| TF | TF:M04953 | Factor: Sp1; motif: GGNDGGRGGCGGGG | Factor: Sp1; motif: GGNDGGRGGCGGGG | 124 | 0.013183 | 0 |
| TF | TF:M10112 | Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR | Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR | 124 | 0.014393 | 0 |
| TF | TF:M09834 | Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN | Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN | 105 | 0.014713 | 0 |
| TF | TF:M00245_1 | Factor: Egr-3; motif: NTGCGTGGGCGK; match class: 1 | Factor: Egr-3; motif: NTGCGTGGGCGK; match class: 1 | 48 | 0.018274 | 0 |
| TF | TF:M01104_1 | Factor: MOVO-B; motif: GNGGGGG; match class: 1 | Factor: MOVO-B; motif: GNGGGGG; match class: 1 | 89 | 0.032774 | 0 |
| TF | TF:M10108 | Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG | Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG | 99 | 0.035356 | 0 |
| TF | TF:M01972_1 | Factor: EGR-1; motif: TGCGTGGGCGK; match class: 1 | Factor: EGR-1; motif: TGCGTGGGCGK; match class: 1 | 34 | 0.047623 | 0 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 140 | 0.048855 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4765 | hsa-mir-4765 | hsa-mir-4765 | 22 | 0.007803 | 0 |
| MIRNA | MIRNA:hsa-mir-670 | hsa-mir-670 | hsa-mir-670 | 31 | 0.008868 | 0 |
| MIRNA | MIRNA:hsa-mir-200b-3p | hsa-mir-200b-3p | hsa-mir-200b-3p | 10 | 0.024354 | 0 |
| MIRNA | MIRNA:hsa-mir-7-5p | hsa-mir-7-5p | hsa-mir-7-5p | 19 | 0.028338 | 0 |
| MIRNA | MIRNA:hsa-mir-34a-3p | hsa-mir-34a-3p | hsa-mir-34a-3p | 7 | 0.043726 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 89 | 5.530402e-38 | 1 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 48 | 1.028087e-24 | 1 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 158 | 1.042181e-24 | 1 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 57 | 8.306907e-24 | 1 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 72 | 1.714415e-23 | 1 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 71 | 3.872132e-23 | 1 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 106 | 8.026464e-23 | 1 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 43 | 2.046078e-20 | 1 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 39 | 2.106946e-19 | 1 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 65 | 2.279486e-19 | 1 |
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 33 | 2.871582e-18 | 1 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 30 | 9.771412e-18 | 1 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 29 | 5.914139e-17 | 1 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 107 | 1.135867e-16 | 1 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 107 | 1.149842e-16 | 1 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 47 | 2.015552e-15 | 1 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 24 | 1.900297e-14 | 1 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 35 | 2.250954e-14 | 1 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 38 | 3.070538e-13 | 1 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 38 | 3.904619e-13 | 1 |
| GO:CC | GO:0031252 | cell leading edge | "The area of a motile cell closest to the direction of movement." [GOC:pg] | 25 | 1.032019e-12 | 1 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 26 | 1.076768e-11 | 1 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 25 | 1.882817e-11 | 1 |
| GO:CC | GO:0005814 | centriole | "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] | 15 | 5.504957e-10 | 1 |
| GO:CC | GO:0005819 | spindle | "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] | 22 | 8.519401e-10 | 1 |
| GO:CC | GO:0030424 | axon | "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] | 26 | 1.843494e-09 | 1 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 28 | 2.373647e-09 | 1 |
| GO:CC | GO:0043005 | neuron projection | "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] | 36 | 1.053473e-08 | 1 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 40 | 1.478360e-08 | 1 |
| GO:CC | GO:0005912 | adherens junction | "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] | 14 | 6.233976e-08 | 1 |
| GO:CC | GO:0030027 | lamellipodium | "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194] | 14 | 1.707824e-07 | 1 |
| GO:CC | GO:0002102 | podosome | "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] | 8 | 2.167906e-07 | 1 |
| GO:CC | GO:0036064 | ciliary basal body | "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193] | 13 | 2.534119e-07 | 1 |
| GO:CC | GO:0098978 | glutamatergic synapse | "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] | 22 | 3.737478e-07 | 1 |
| GO:CC | GO:0034451 | centriolar satellite | "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812] | 11 | 1.300709e-06 | 1 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 162 | 3.020026e-06 | 1 |
| GO:CC | GO:0072686 | mitotic spindle | "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] | 12 | 5.662224e-06 | 1 |
| GO:CC | GO:0030863 | cortical cytoskeleton | "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] | 10 | 7.097144e-06 | 1 |
| GO:CC | GO:0043296 | apical junction complex | "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556] | 11 | 8.912411e-06 | 1 |
| GO:CC | GO:0030425 | dendrite | "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] | 20 | 2.522242e-05 | 1 |
| GO:CC | GO:0097447 | dendritic tree | "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168] | 20 | 2.653912e-05 | 1 |
| GO:CC | GO:0098984 | neuron to neuron synapse | "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos] | 16 | 3.161976e-05 | 1 |
| GO:CC | GO:0000922 | spindle pole | "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] | 11 | 4.125897e-05 | 1 |
| GO:CC | GO:0001726 | ruffle | "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] | 11 | 5.153853e-05 | 1 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 155 | 5.230322e-05 | 1 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 150 | 1.054562e-04 | 1 |
| GO:CC | GO:0099572 | postsynaptic specialization | "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028] | 15 | 1.137117e-04 | 1 |
| GO:CC | GO:0005915 | zonula adherens | "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208] | 4 | 1.156217e-04 | 1 |
| GO:CC | GO:0005875 | microtubule associated complex | "Any multimeric complex connected to a microtubule." [GOC:jl] | 10 | 1.187610e-04 | 1 |
| GO:CC | GO:0005884 | actin filament | "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] | 9 | 1.279401e-04 | 1 |
| GO:CC | GO:0042641 | actomyosin | "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] | 8 | 1.650726e-04 | 1 |
| GO:CC | GO:0030496 | midbody | "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] | 11 | 1.758209e-04 | 1 |
| GO:CC | GO:0005929 | cilium | "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] | 21 | 1.949343e-04 | 1 |
| GO:CC | GO:0030426 | growth cone | "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] | 10 | 1.972946e-04 | 1 |
| GO:CC | GO:0036477 | somatodendritic compartment | "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL] | 22 | 2.007451e-04 | 1 |
| GO:CC | GO:0030427 | site of polarized growth | "Any part of a cell where non-isotropic growth takes place." [GOC:mah] | 10 | 2.581036e-04 | 1 |
| GO:CC | GO:0098590 | plasma membrane region | "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] | 28 | 2.827523e-04 | 1 |
| GO:CC | GO:0032279 | asymmetric synapse | "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] | 14 | 3.235763e-04 | 1 |
| GO:CC | GO:0044291 | cell-cell contact zone | "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018] | 7 | 5.395746e-04 | 1 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 106 | 6.672930e-04 | 1 |
| GO:CC | GO:0014704 | intercalated disc | "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910] | 6 | 8.901258e-04 | 1 |
| GO:CC | GO:0014069 | postsynaptic density | "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density] | 13 | 1.102973e-03 | 1 |
| GO:CC | GO:0030864 | cortical actin cytoskeleton | "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] | 7 | 1.150127e-03 | 1 |
| GO:CC | GO:0097517 | contractile actin filament bundle | "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194] | 7 | 1.244063e-03 | 1 |
| GO:CC | GO:0001725 | stress fiber | "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] | 7 | 1.244063e-03 | 1 |
| GO:CC | GO:0048471 | perinuclear region of cytoplasm | "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] | 19 | 1.303599e-03 | 1 |
| GO:CC | GO:0016328 | lateral plasma membrane | "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] | 7 | 1.451179e-03 | 1 |
| GO:CC | GO:1990752 | microtubule end | "Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end." [GOC:pr] | 5 | 2.192880e-03 | 1 |
| GO:CC | GO:0032432 | actin filament bundle | "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] | 7 | 2.415537e-03 | 1 |
| GO:CC | GO:0150034 | distal axon | "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] | 11 | 3.201048e-03 | 1 |
| GO:CC | GO:0000932 | P-body | "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603] | 7 | 3.618554e-03 | 1 |
| GO:CC | GO:0030056 | hemidesmosome | "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195] | 3 | 4.316307e-03 | 1 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 74 | 5.340320e-03 | 1 |
| GO:CC | GO:0000242 | pericentriolar material | "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] | 4 | 6.211682e-03 | 1 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 10 | 8.812876e-03 | 1 |
| GO:CC | GO:0099091 | postsynaptic specialization, intracellular component | "A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos] | 4 | 8.916461e-03 | 1 |
| GO:CC | GO:0120103 | centriolar subdistal appendage | "A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68." [GOC:cilia, PMID:23213374, PMID:27818179, PMID:28422092] | 3 | 1.455100e-02 | 1 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 10 | 1.604331e-02 | 1 |
| GO:CC | GO:0000776 | kinetochore | "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] | 8 | 1.634203e-02 | 1 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 68 | 1.889818e-02 | 1 |
| GO:CC | GO:0043197 | dendritic spine | "A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln] | 8 | 2.076970e-02 | 1 |
| GO:CC | GO:0044309 | neuron spine | "A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck." [ISBN:0198504888, NIF_Subcellular:sao1145756102] | 8 | 2.424232e-02 | 1 |
| GO:CC | GO:0016342 | catenin complex | "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] | 4 | 2.532597e-02 | 1 |
| GO:CC | GO:0000779 | condensed chromosome, centromeric region | "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] | 8 | 2.615140e-02 | 1 |
| GO:CC | GO:0032587 | ruffle membrane | "The portion of the plasma membrane surrounding a ruffle." [GOC:mah] | 6 | 3.634133e-02 | 1 |
| GO:CC | GO:1904115 | axon cytoplasm | "Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152] | 5 | 3.733348e-02 | 1 |
| GO:CC | GO:0098685 | Schaffer collateral - CA1 synapse | "A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell." [PMID:16399689] | 6 | 4.270085e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 72 | 2.940390e-34 | 1 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 89 | 6.943126e-23 | 1 |
| GO:BP | GO:0007017 | microtubule-based process | "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] | 43 | 8.983688e-17 | 1 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 36 | 1.350071e-16 | 1 |
| GO:BP | GO:0030030 | cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917] | 53 | 4.609953e-16 | 1 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 69 | 5.161519e-16 | 1 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 69 | 6.544606e-16 | 1 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 79 | 1.769165e-15 | 1 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] | 51 | 4.488714e-15 | 1 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 72 | 2.789509e-14 | 1 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 61 | 1.234345e-13 | 1 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] | 21 | 5.226294e-13 | 1 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 35 | 2.711039e-12 | 1 |
| GO:BP | GO:0034330 | cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] | 34 | 6.762048e-12 | 1 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 26 | 1.456568e-10 | 1 |
| GO:BP | GO:0000902 | cell morphogenesis | "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] | 34 | 1.103850e-09 | 1 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 29 | 1.724137e-09 | 1 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 34 | 1.773690e-09 | 1 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 88 | 1.808556e-09 | 1 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 32 | 2.466184e-09 | 1 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 111 | 2.758954e-09 | 1 |
| GO:BP | GO:0030010 | establishment of cell polarity | "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] | 15 | 5.368313e-09 | 1 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 30 | 6.453946e-09 | 1 |
| GO:BP | GO:0032886 | regulation of microtubule-based process | "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] | 18 | 9.720196e-09 | 1 |
| GO:BP | GO:0031175 | neuron projection development | "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] | 33 | 1.181176e-08 | 1 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 47 | 1.791025e-08 | 1 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 111 | 1.815892e-08 | 1 |
| GO:BP | GO:0070925 | organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 33 | 2.139962e-08 | 1 |
| GO:BP | GO:0048666 | neuron development | "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] | 35 | 2.387369e-08 | 1 |
| GO:BP | GO:0072698 | protein localization to microtubule cytoskeleton | "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah] | 10 | 5.752418e-08 | 1 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 139 | 7.238976e-08 | 1 |
| GO:BP | GO:0007399 | nervous system development | "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] | 53 | 1.097181e-07 | 1 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 37 | 1.132194e-07 | 1 |
| GO:BP | GO:0030182 | neuron differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] | 38 | 1.144423e-07 | 1 |
| GO:BP | GO:0044380 | protein localization to cytoskeleton | "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl] | 10 | 1.153070e-07 | 1 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 69 | 1.367033e-07 | 1 |
| GO:BP | GO:0048699 | generation of neurons | "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] | 39 | 1.514998e-07 | 1 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 141 | 1.641250e-07 | 1 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 31 | 2.017960e-07 | 1 |
| GO:BP | GO:0022008 | neurogenesis | "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] | 42 | 2.019996e-07 | 1 |
| GO:BP | GO:0034329 | cell junction assembly | "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah] | 22 | 2.072229e-07 | 1 |
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 21 | 2.700013e-07 | 1 |
| GO:BP | GO:0048870 | cell motility | "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] | 42 | 2.965185e-07 | 1 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 135 | 3.478282e-07 | 1 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 19 | 5.172923e-07 | 1 |
| GO:BP | GO:0031023 | microtubule organizing center organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] | 13 | 5.925779e-07 | 1 |
| GO:BP | GO:0071539 | protein localization to centrosome | "A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd] | 8 | 8.338145e-07 | 1 |
| GO:BP | GO:0051656 | establishment of organelle localization | "The directed movement of an organelle to a specific location." [GOC:ai] | 21 | 8.505442e-07 | 1 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb] | 23 | 9.740171e-07 | 1 |
| GO:BP | GO:0120031 | plasma membrane bounded cell projection assembly | "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 23 | 1.005970e-06 | 1 |
| GO:BP | GO:1905508 | protein localization to microtubule organizing center | "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497] | 8 | 1.048983e-06 | 1 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 32 | 1.062993e-06 | 1 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 55 | 1.120790e-06 | 1 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 86 | 1.188766e-06 | 1 |
| GO:BP | GO:0030031 | cell projection assembly | "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:18391171] | 23 | 1.521359e-06 | 1 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] | 52 | 1.581030e-06 | 1 |
| GO:BP | GO:0051640 | organelle localization | "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] | 23 | 1.892410e-06 | 1 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc] | 24 | 1.899635e-06 | 1 |
| GO:BP | GO:0034453 | microtubule anchoring | "Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah] | 7 | 1.975950e-06 | 1 |
| GO:BP | GO:0016477 | cell migration | "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] | 37 | 2.139954e-06 | 1 |
| GO:BP | GO:0048858 | cell projection morphogenesis | "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021] | 24 | 2.198146e-06 | 1 |
| GO:BP | GO:0007098 | centrosome cycle | "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] | 12 | 2.624413e-06 | 1 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 90 | 3.324730e-06 | 1 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] | 23 | 6.224431e-06 | 1 |
| GO:BP | GO:0022607 | cellular component assembly | "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] | 72 | 6.629623e-06 | 1 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 72 | 7.156327e-06 | 1 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 59 | 8.268280e-06 | 1 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 33 | 9.413456e-06 | 1 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] | 10 | 9.569353e-06 | 1 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 42 | 1.238221e-05 | 1 |
| GO:BP | GO:0070507 | regulation of microtubule cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 12 | 1.596127e-05 | 1 |
| GO:BP | GO:0150115 | cell-substrate junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 10 | 1.907122e-05 | 1 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 18 | 2.241639e-05 | 1 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 58 | 2.475248e-05 | 1 |
| GO:BP | GO:0007155 | cell adhesion | "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] | 35 | 2.565262e-05 | 1 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 73 | 2.880668e-05 | 1 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 22 | 2.959248e-05 | 1 |
| GO:BP | GO:0045216 | cell-cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 13 | 3.749739e-05 | 1 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 30 | 5.625645e-05 | 1 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 33 | 6.371890e-05 | 1 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 33 | 6.478420e-05 | 1 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 50 | 9.688915e-05 | 1 |
| GO:BP | GO:0071896 | protein localization to adherens junction | "Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237] | 4 | 1.065493e-04 | 1 |
| GO:BP | GO:0072393 | microtubule anchoring at microtubule organizing center | "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938] | 5 | 1.065919e-04 | 1 |
| GO:BP | GO:0032271 | regulation of protein polymerization | "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 12 | 1.374421e-04 | 1 |
| GO:BP | GO:0051258 | protein polymerization | "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] | 14 | 1.375582e-04 | 1 |
| GO:BP | GO:0031344 | regulation of cell projection organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] | 21 | 1.414969e-04 | 1 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 51 | 2.009920e-04 | 1 |
| GO:BP | GO:0030705 | cytoskeleton-dependent intracellular transport | "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] | 12 | 2.348303e-04 | 1 |
| GO:BP | GO:0045184 | establishment of protein localization | "The directed movement of a protein to a specific location." [GOC:bf] | 38 | 3.156405e-04 | 1 |
| GO:BP | GO:0016055 | Wnt signaling pathway | "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397] | 17 | 3.267038e-04 | 1 |
| GO:BP | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] | 7 | 3.371665e-04 | 1 |
| GO:BP | GO:0031589 | cell-substrate adhesion | "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] | 15 | 3.586837e-04 | 1 |
| GO:BP | GO:0010970 | transport along microtubule | "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] | 11 | 3.804614e-04 | 1 |
| GO:BP | GO:0007409 | axonogenesis | "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] | 17 | 3.808252e-04 | 1 |
| GO:BP | GO:0110053 | regulation of actin filament organization | "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] | 13 | 3.955316e-04 | 1 |
| GO:BP | GO:0099111 | microtubule-based transport | "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] | 12 | 4.093879e-04 | 1 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc] | 20 | 4.344825e-04 | 1 |
| GO:BP | GO:0061564 | axon development | "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr] | 18 | 4.910310e-04 | 1 |
| GO:BP | GO:1990778 | protein localization to cell periphery | "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] | 15 | 4.937726e-04 | 1 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 34 | 6.302740e-04 | 1 |
| GO:BP | GO:0035088 | establishment or maintenance of apical/basal cell polarity | "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483] | 7 | 6.442147e-04 | 1 |
| GO:BP | GO:0061245 | establishment or maintenance of bipolar cell polarity | "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns." [GOC:dph, GOC:vw] | 7 | 6.442147e-04 | 1 |
| GO:BP | GO:0030865 | cortical cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] | 7 | 6.442147e-04 | 1 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 29 | 6.731320e-04 | 1 |
| GO:BP | GO:0048041 | focal adhesion assembly | "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah] | 8 | 7.493370e-04 | 1 |
| GO:BP | GO:0007160 | cell-matrix adhesion | "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] | 12 | 9.091691e-04 | 1 |
| GO:BP | GO:0007043 | cell-cell junction assembly | "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] | 10 | 9.833250e-04 | 1 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] | 12 | 1.039322e-03 | 1 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 17 | 1.083451e-03 | 1 |
| GO:BP | GO:0032501 | multicellular organismal process | "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] | 90 | 1.146435e-03 | 1 |
| GO:BP | GO:0072659 | protein localization to plasma membrane | "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] | 13 | 1.250089e-03 | 1 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 83 | 1.281730e-03 | 1 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 25 | 1.648069e-03 | 1 |
| GO:BP | GO:0060271 | cilium assembly | "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441] | 15 | 1.723717e-03 | 1 |
| GO:BP | GO:0030154 | cell differentiation | "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] | 63 | 1.772479e-03 | 1 |
| GO:BP | GO:0048869 | cellular developmental process | "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] | 63 | 1.786895e-03 | 1 |
| GO:BP | GO:0032535 | regulation of cellular component size | "A process that modulates the size of a cellular component." [GOC:mah] | 14 | 2.111950e-03 | 1 |
| GO:BP | GO:0031032 | actomyosin structure organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] | 11 | 2.166626e-03 | 1 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] | 13 | 2.276448e-03 | 1 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 33 | 2.367613e-03 | 1 |
| GO:BP | GO:0031503 | protein-containing complex localization | "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] | 11 | 2.486260e-03 | 1 |
| GO:BP | GO:0030859 | polarized epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:mah] | 5 | 2.633324e-03 | 1 |
| GO:BP | GO:0007018 | microtubule-based movement | "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] | 16 | 2.968557e-03 | 1 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 76 | 3.839021e-03 | 1 |
| GO:BP | GO:0044782 | cilium organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] | 15 | 3.956528e-03 | 1 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] | 14 | 4.007641e-03 | 1 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 81 | 4.996333e-03 | 1 |
| GO:BP | GO:0043297 | apical junction assembly | "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556] | 7 | 5.120864e-03 | 1 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] | 13 | 5.227231e-03 | 1 |
| GO:BP | GO:0050808 | synapse organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] | 17 | 5.585429e-03 | 1 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] | 13 | 5.769450e-03 | 1 |
| GO:BP | GO:0010975 | regulation of neuron projection development | "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] | 15 | 6.007192e-03 | 1 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 34 | 7.389567e-03 | 1 |
| GO:BP | GO:0016358 | dendrite development | "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] | 11 | 7.808719e-03 | 1 |
| GO:BP | GO:0051960 | regulation of nervous system development | "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] | 15 | 8.068596e-03 | 1 |
| GO:BP | GO:0051494 | negative regulation of cytoskeleton organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 9 | 8.319938e-03 | 1 |
| GO:BP | GO:1902904 | negative regulation of supramolecular fiber organization | "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 9 | 9.238949e-03 | 1 |
| GO:BP | GO:0034332 | adherens junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah] | 6 | 1.138573e-02 | 1 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] | 8 | 1.165754e-02 | 1 |
| GO:BP | GO:0031346 | positive regulation of cell projection organization | "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] | 13 | 1.187576e-02 | 1 |
| GO:BP | GO:0007051 | spindle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] | 10 | 1.208679e-02 | 1 |
| GO:BP | GO:0030837 | negative regulation of actin filament polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] | 6 | 1.261550e-02 | 1 |
| GO:BP | GO:0051234 | establishment of localization | "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] | 65 | 1.496953e-02 | 1 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488] | 12 | 1.521250e-02 | 1 |
| GO:BP | GO:0030833 | regulation of actin filament polymerization | "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] | 8 | 1.661789e-02 | 1 |
| GO:BP | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA | "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544] | 3 | 1.789825e-02 | 1 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 77 | 1.799857e-02 | 1 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] | 10 | 1.907065e-02 | 1 |
| GO:BP | GO:0006886 | intracellular protein transport | "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] | 18 | 1.960422e-02 | 1 |
| GO:BP | GO:0090109 | regulation of cell-substrate junction assembly | "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb] | 6 | 2.048681e-02 | 1 |
| GO:BP | GO:0051893 | regulation of focal adhesion assembly | "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai] | 6 | 2.048681e-02 | 1 |
| GO:BP | GO:0050767 | regulation of neurogenesis | "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai] | 13 | 2.185905e-02 | 1 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb] | 15 | 2.354645e-02 | 1 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | "An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah] | 15 | 2.646150e-02 | 1 |
| GO:BP | GO:0031109 | microtubule polymerization or depolymerization | "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] | 8 | 2.881358e-02 | 1 |
| GO:BP | GO:0035735 | intraciliary transport involved in cilium assembly | "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia] | 3 | 3.113664e-02 | 1 |
| GO:BP | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay | "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544] | 3 | 3.113664e-02 | 1 |
| GO:BP | GO:0150116 | regulation of cell-substrate junction organization | "Any process that modulates the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] | 6 | 3.192642e-02 | 1 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 43 | 3.421913e-02 | 1 |
| GO:BP | GO:0060429 | epithelium development | "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] | 25 | 3.465516e-02 | 1 |
| GO:BP | GO:0050770 | regulation of axonogenesis | "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] | 8 | 4.333276e-02 | 1 |
| GO:BP | GO:0032272 | negative regulation of protein polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 6 | 4.438152e-02 | 1 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] | 9 | 4.458694e-02 | 1 |
| GO:BP | GO:0008064 | regulation of actin polymerization or depolymerization | "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] | 8 | 4.551689e-02 | 1 |
| GO:BP | GO:0048589 | developmental growth | "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] | 17 | 4.669926e-02 | 1 |
| GO:BP | GO:0150105 | protein localization to cell-cell junction | "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] | 4 | 4.698923e-02 | 1 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 23 | 4.832606e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 55 | 7.928756e-27 | 1 |
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 28 | 8.676221e-14 | 1 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 30 | 7.322626e-13 | 1 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 168 | 2.991812e-12 | 1 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 23 | 1.025807e-11 | 1 |
| GO:MF | GO:0008017 | microtubule binding | "Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc] | 17 | 2.399025e-07 | 1 |
| GO:MF | GO:0051015 | actin filament binding | "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 15 | 2.592555e-07 | 1 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 46 | 1.181746e-06 | 1 |
| GO:MF | GO:0015631 | tubulin binding | "Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] | 18 | 5.723139e-06 | 1 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 25 | 1.438322e-05 | 1 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 32 | 5.216788e-05 | 1 |
| GO:MF | GO:0008013 | beta-catenin binding | "Binding to a catenin beta subunit." [GOC:bf] | 9 | 2.649898e-04 | 1 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 20 | 6.480201e-04 | 1 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 21 | 6.643858e-04 | 1 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 28 | 1.087066e-03 | 1 |
| GO:MF | GO:0017166 | vinculin binding | "Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544] | 4 | 1.670449e-03 | 1 |
| GO:MF | GO:0051011 | microtubule minus-end binding | "Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] | 4 | 2.396690e-03 | 1 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 172 | 1.460662e-02 | 1 |
| GO:MF | GO:0048156 | tau protein binding | "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] | 5 | 2.209983e-02 | 1 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 19 | 3.284473e-02 | 1 |
| GO:MF | GO:0008093 | cytoskeletal anchor activity | "The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238] | 4 | 3.308117e-02 | 1 |
| GO:MF | GO:0005200 | structural constituent of cytoskeleton | "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] | 7 | 3.940769e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 35 | 3.559979e-13 | 1 |
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 33 | 8.966724e-12 | 1 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 62 | 2.747814e-11 | 1 |
| REAC | REAC:R-HSA-380259 | Loss of Nlp from mitotic centrosomes | Loss of Nlp from mitotic centrosomes | 11 | 2.641123e-08 | 1 |
| REAC | REAC:R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | Loss of proteins required for interphase microtubule organization from the centrosome | 11 | 2.641123e-08 | 1 |
| REAC | REAC:R-HSA-8854518 | AURKA Activation by TPX2 | AURKA Activation by TPX2 | 11 | 4.302766e-08 | 1 |
| REAC | REAC:R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | Recruitment of mitotic centrosome proteins and complexes | 11 | 1.633920e-07 | 1 |
| REAC | REAC:R-HSA-380287 | Centrosome maturation | Centrosome maturation | 11 | 1.633920e-07 | 1 |
| REAC | REAC:R-HSA-9012999 | RHO GTPase cycle | RHO GTPase cycle | 22 | 2.069399e-07 | 1 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 11 | 3.191778e-07 | 1 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 11 | 9.585022e-07 | 1 |
| REAC | REAC:R-HSA-111465 | Apoptotic cleavage of cellular proteins | Apoptotic cleavage of cellular proteins | 8 | 1.083113e-06 | 1 |
| REAC | REAC:R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | Anchoring of the basal body to the plasma membrane | 11 | 1.204137e-06 | 1 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 13 | 9.162830e-06 | 1 |
| REAC | REAC:R-HSA-1500931 | Cell-Cell communication | Cell-Cell communication | 12 | 1.368723e-05 | 1 |
| REAC | REAC:R-HSA-75153 | Apoptotic execution phase | Apoptotic execution phase | 8 | 1.591030e-05 | 1 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 13 | 6.622558e-05 | 1 |
| REAC | REAC:R-HSA-446728 | Cell junction organization | Cell junction organization | 10 | 8.717253e-05 | 1 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 12 | 2.578643e-04 | 1 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 12 | 2.874893e-04 | 1 |
| REAC | REAC:R-HSA-68877 | Mitotic Prometaphase | Mitotic Prometaphase | 12 | 3.201022e-04 | 1 |
| REAC | REAC:R-HSA-199991 | Membrane Trafficking | Membrane Trafficking | 21 | 3.649455e-04 | 1 |
| REAC | REAC:R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | COPI-independent Golgi-to-ER retrograde traffic | 7 | 4.021625e-04 | 1 |
| REAC | REAC:R-HSA-9013424 | RHOV GTPase cycle | RHOV GTPase cycle | 6 | 7.276558e-04 | 1 |
| REAC | REAC:R-HSA-9696264 | RND3 GTPase cycle | RND3 GTPase cycle | 6 | 1.576659e-03 | 1 |
| REAC | REAC:R-HSA-5617833 | Cilium Assembly | Cilium Assembly | 11 | 2.230683e-03 | 1 |
| REAC | REAC:R-HSA-5653656 | Vesicle-mediated transport | Vesicle-mediated transport | 21 | 3.375941e-03 | 1 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 5 | 4.924894e-03 | 1 |
| REAC | REAC:R-HSA-195258 | RHO GTPase Effectors | RHO GTPase Effectors | 13 | 7.575663e-03 | 1 |
| REAC | REAC:R-HSA-9013404 | RAC2 GTPase cycle | RAC2 GTPase cycle | 7 | 1.243113e-02 | 1 |
| REAC | REAC:R-HSA-2028269 | Signaling by Hippo | Signaling by Hippo | 4 | 1.511003e-02 | 1 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 15 | 1.554846e-02 | 1 |
| REAC | REAC:R-HSA-9013420 | RHOU GTPase cycle | RHOU GTPase cycle | 5 | 1.852370e-02 | 1 |
| REAC | REAC:R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | Signaling by Receptor Tyrosine Kinases | 16 | 2.349749e-02 | 1 |
| REAC | REAC:R-HSA-8856688 | Golgi-to-ER retrograde transport | Golgi-to-ER retrograde transport | 8 | 2.487066e-02 | 1 |
| REAC | REAC:R-HSA-9696273 | RND1 GTPase cycle | RND1 GTPase cycle | 5 | 2.672394e-02 | 1 |
| REAC | REAC:R-HSA-9696270 | RND2 GTPase cycle | RND2 GTPase cycle | 5 | 3.000109e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M02036 | Factor: WT1; motif: CGCCCCCNCN | Factor: WT1; motif: CGCCCCCNCN | 138 | 2.305626e-11 | 1 |
| TF | TF:M00695_1 | Factor: ETF; motif: GVGGMGG; match class: 1 | Factor: ETF; motif: GVGGMGG; match class: 1 | 112 | 2.477433e-10 | 1 |
| TF | TF:M07208 | Factor: EGR1; motif: NCNCCGCCCCCGCN | Factor: EGR1; motif: NCNCCGCCCCCGCN | 102 | 2.179115e-09 | 1 |
| TF | TF:M01873 | Factor: Egr-1; motif: GCGGGGGCGG | Factor: Egr-1; motif: GCGGGGGCGG | 107 | 2.771469e-09 | 1 |
| TF | TF:M13127_1 | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1 | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1 | 120 | 3.687219e-08 | 1 |
| TF | TF:M07354 | Factor: Egr-1; motif: GCGGGGGCGG | Factor: Egr-1; motif: GCGGGGGCGG | 114 | 2.292663e-07 | 1 |
| TF | TF:M02089_1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | 127 | 2.411051e-07 | 1 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 135 | 4.156253e-07 | 1 |
| TF | TF:M10108 | Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG | Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG | 100 | 5.776961e-07 | 1 |
| TF | TF:M03893 | Factor: WT1; motif: GNGGGGGCGGGG | Factor: WT1; motif: GNGGGGGCGGGG | 116 | 9.580296e-07 | 1 |
| TF | TF:M00982 | Factor: KROX; motif: CCCGCCCCCRCCCC | Factor: KROX; motif: CCCGCCCCCRCCCC | 111 | 2.181715e-06 | 1 |
| TF | TF:M02036_1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | 86 | 2.742169e-06 | 1 |
| TF | TF:M01219_1 | Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1 | Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1 | 59 | 3.002434e-06 | 1 |
| TF | TF:M07329 | Factor: Osx; motif: CCNCCCCCNNN | Factor: Osx; motif: CCNCCCCCNNN | 101 | 3.586267e-06 | 1 |
| TF | TF:M01219 | Factor: SP1:SP3; motif: CCSCCCCCYCC | Factor: SP1:SP3; motif: CCSCCCCCYCC | 100 | 7.081455e-06 | 1 |
| TF | TF:M09636_1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | 159 | 8.564566e-06 | 1 |
| TF | TF:M13144_1 | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS; match class: 1 | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS; match class: 1 | 85 | 8.836223e-06 | 1 |
| TF | TF:M12722_1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | 98 | 1.038020e-05 | 1 |
| TF | TF:M08878 | Factor: EGR; motif: CGCCCCCGCNN | Factor: EGR; motif: CGCCCCCGCNN | 106 | 1.194013e-05 | 1 |
| TF | TF:M12703_1 | Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1 | Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1 | 74 | 1.270724e-05 | 1 |
| TF | TF:M09826 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | 141 | 1.518770e-05 | 1 |
| TF | TF:M11529_1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | 161 | 1.623129e-05 | 1 |
| TF | TF:M00196 | Factor: Sp1; motif: NGGGGGCGGGGYN | Factor: Sp1; motif: NGGGGGCGGGGYN | 130 | 1.676250e-05 | 1 |
| TF | TF:M13366 | Factor: ZBED4; motif: CCCGCYCCGC | Factor: ZBED4; motif: CCCGCYCCGC | 107 | 2.129465e-05 | 1 |
| TF | TF:M09826_1 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 | 107 | 2.271086e-05 | 1 |
| TF | TF:M02089 | Factor: E2F-3; motif: GGCGGGN | Factor: E2F-3; motif: GGCGGGN | 152 | 2.337288e-05 | 1 |
| TF | TF:M01104_1 | Factor: MOVO-B; motif: GNGGGGG; match class: 1 | Factor: MOVO-B; motif: GNGGGGG; match class: 1 | 87 | 2.826504e-05 | 1 |
| TF | TF:M08878_1 | Factor: EGR; motif: CGCCCCCGCNN; match class: 1 | Factor: EGR; motif: CGCCCCCGCNN; match class: 1 | 60 | 2.975118e-05 | 1 |
| TF | TF:M01104 | Factor: MOVO-B; motif: GNGGGGG | Factor: MOVO-B; motif: GNGGGGG | 129 | 4.179511e-05 | 1 |
| TF | TF:M00986_1 | Factor: Churchill; motif: CGGGNN; match class: 1 | Factor: Churchill; motif: CGGGNN; match class: 1 | 130 | 4.730344e-05 | 1 |
| TF | TF:M11531 | Factor: E2F-2; motif: GCGCGCGCGYW | Factor: E2F-2; motif: GCGCGCGCGYW | 152 | 4.811747e-05 | 1 |
| TF | TF:M10072 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | 131 | 5.167236e-05 | 1 |
| TF | TF:M09761 | Factor: EGR1; motif: NGNGKGGGYGGNGS | Factor: EGR1; motif: NGNGKGGGYGGNGS | 81 | 6.046444e-05 | 1 |
| TF | TF:M10026 | Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN | Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN | 111 | 7.156506e-05 | 1 |
| TF | TF:M07289_1 | Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1 | Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1 | 131 | 7.567338e-05 | 1 |
| TF | TF:M13366_1 | Factor: ZBED4; motif: CCCGCYCCGC; match class: 1 | Factor: ZBED4; motif: CCCGCYCCGC; match class: 1 | 66 | 8.575155e-05 | 1 |
| TF | TF:M12703 | Factor: ZNF383; motif: SSNGGGMGGNGSNGGS | Factor: ZNF383; motif: SSNGGGMGGNGSNGGS | 118 | 9.579206e-05 | 1 |
| TF | TF:M07354_1 | Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 | Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 | 64 | 9.640036e-05 | 1 |
| TF | TF:M07615 | Factor: Sp3; motif: GGGGCGGGGSNN | Factor: Sp3; motif: GGGGCGGGGSNN | 97 | 1.038289e-04 | 1 |
| TF | TF:M13124 | Factor: ZNF670; motif: SNGGGCRGRG | Factor: ZNF670; motif: SNGGGCRGRG | 147 | 1.516389e-04 | 1 |
| TF | TF:M01199_1 | Factor: RNF96; motif: BCCCGCRGCC; match class: 1 | Factor: RNF96; motif: BCCCGCRGCC; match class: 1 | 71 | 1.564952e-04 | 1 |
| TF | TF:M03567 | Factor: Sp2; motif: NYSGCCCCGCCCCCY | Factor: Sp2; motif: NYSGCCCCGCCCCCY | 105 | 1.620928e-04 | 1 |
| TF | TF:M00803_1 | Factor: E2F; motif: GGCGSG; match class: 1 | Factor: E2F; motif: GGCGSG; match class: 1 | 127 | 1.882561e-04 | 1 |
| TF | TF:M07039_1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | 153 | 2.172065e-04 | 1 |
| TF | TF:M07226_1 | Factor: SP1; motif: NCCCCKCCCCC; match class: 1 | Factor: SP1; motif: NCCCCKCCCCC; match class: 1 | 66 | 2.386844e-04 | 1 |
| TF | TF:M09984 | Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG | Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG | 121 | 2.628909e-04 | 1 |
| TF | TF:M03807 | Factor: SP2; motif: GNNGGGGGCGGGGSN | Factor: SP2; motif: GNNGGGGGCGGGGSN | 111 | 2.731798e-04 | 1 |
| TF | TF:M00931_1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | 87 | 3.036247e-04 | 1 |
| TF | TF:M08867_1 | Factor: AP2; motif: GCCYGSGGSN; match class: 1 | Factor: AP2; motif: GCCYGSGGSN; match class: 1 | 79 | 3.076148e-04 | 1 |
| TF | TF:M04953 | Factor: Sp1; motif: GGNDGGRGGCGGGG | Factor: Sp1; motif: GGNDGGRGGCGGGG | 113 | 3.211170e-04 | 1 |
| TF | TF:M07395 | Factor: Sp1; motif: NGGGGCGGGGN | Factor: Sp1; motif: NGGGGCGGGGN | 130 | 3.338728e-04 | 1 |
| TF | TF:M00931 | Factor: Sp1; motif: GGGGCGGGGC | Factor: Sp1; motif: GGGGCGGGGC | 127 | 3.378910e-04 | 1 |
| TF | TF:M00982_1 | Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1 | Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1 | 61 | 3.630706e-04 | 1 |
| TF | TF:M10072_1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | 90 | 3.887856e-04 | 1 |
| TF | TF:M00933_1 | Factor: Sp1; motif: CCCCGCCCCN; match class: 1 | Factor: Sp1; motif: CCCCGCCCCN; match class: 1 | 79 | 4.245512e-04 | 1 |
| TF | TF:M07277 | Factor: BTEB2; motif: RGGGNGKGGN | Factor: BTEB2; motif: RGGGNGKGGN | 111 | 4.425593e-04 | 1 |
| TF | TF:M07395_1 | Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 | Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 | 91 | 4.507349e-04 | 1 |
| TF | TF:M13147_1 | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN; match class: 1 | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN; match class: 1 | 93 | 5.148467e-04 | 1 |
| TF | TF:M07277_1 | Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 | Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 | 68 | 5.153761e-04 | 1 |
| TF | TF:M13129_1 | Factor: RERE; motif: CNGCNSCNNGSRCRGSGSS; match class: 1 | Factor: RERE; motif: CNGCNSCNNGSRCRGSGSS; match class: 1 | 85 | 5.157578e-04 | 1 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 149 | 5.577901e-04 | 1 |
| TF | TF:M09723 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | 124 | 5.884358e-04 | 1 |
| TF | TF:M12351_1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | 107 | 5.932535e-04 | 1 |
| TF | TF:M09973_1 | Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 | Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 | 93 | 7.133542e-04 | 1 |
| TF | TF:M10435 | Factor: Sp2; motif: GGGGCGGGG | Factor: Sp2; motif: GGGGCGGGG | 103 | 7.661026e-04 | 1 |
| TF | TF:M00933 | Factor: Sp1; motif: CCCCGCCCCN | Factor: Sp1; motif: CCCCGCCCCN | 121 | 7.897623e-04 | 1 |
| TF | TF:M00932 | Factor: Sp1; motif: NNGGGGCGGGGNN | Factor: Sp1; motif: NNGGGGCGGGGNN | 127 | 9.014363e-04 | 1 |
| TF | TF:M12227 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN | Factor: ZIC4; motif: NNCCNCCCRYNGYGN | 132 | 9.496663e-04 | 1 |
| TF | TF:M00932_1 | Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 | Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 | 87 | 9.674137e-04 | 1 |
| TF | TF:M01199 | Factor: RNF96; motif: BCCCGCRGCC | Factor: RNF96; motif: BCCCGCRGCC | 110 | 9.930966e-04 | 1 |
| TF | TF:M10432 | Factor: MAZ; motif: GGGMGGGGS | Factor: MAZ; motif: GGGMGGGGS | 117 | 1.093032e-03 | 1 |
| TF | TF:M12648 | Factor: PATZ1; motif: SCNCCNCNSCCCCCASCCN | Factor: PATZ1; motif: SCNCCNCNSCCCCCASCCN | 69 | 1.233177e-03 | 1 |
| TF | TF:M10112 | Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR | Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR | 111 | 1.739546e-03 | 1 |
| TF | TF:M01303 | Factor: SP1; motif: GGGGYGGGGNS | Factor: SP1; motif: GGGGYGGGGNS | 104 | 1.887451e-03 | 1 |
| TF | TF:M07063 | Factor: Sp1; motif: GGGGCGGGGC | Factor: Sp1; motif: GGGGCGGGGC | 88 | 1.985779e-03 | 1 |
| TF | TF:M01873_1 | Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 | Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 | 49 | 2.128961e-03 | 1 |
| TF | TF:M02090_1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | 89 | 2.227700e-03 | 1 |
| TF | TF:M07329_1 | Factor: Osx; motif: CCNCCCCCNNN; match class: 1 | Factor: Osx; motif: CCNCCCCCNNN; match class: 1 | 47 | 2.377963e-03 | 1 |
| TF | TF:M08441_1 | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 | 144 | 2.382335e-03 | 1 |
| TF | TF:M10071_1 | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 | 71 | 2.414578e-03 | 1 |
| TF | TF:M10112_1 | Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR; match class: 1 | Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR; match class: 1 | 65 | 2.428511e-03 | 1 |
| TF | TF:M10026_1 | Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN; match class: 1 | Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN; match class: 1 | 73 | 2.508676e-03 | 1 |
| TF | TF:M01303_1 | Factor: SP1; motif: GGGGYGGGGNS; match class: 1 | Factor: SP1; motif: GGGGYGGGGNS; match class: 1 | 59 | 2.525730e-03 | 1 |
| TF | TF:M07436 | Factor: WT1; motif: NNGGGNGGGSGN | Factor: WT1; motif: NNGGGNGGGSGN | 90 | 2.634530e-03 | 1 |
| TF | TF:M11531_1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | 141 | 2.673813e-03 | 1 |
| TF | TF:M13128 | Factor: MED8; motif: CYYNSCYYCCTSCNCC | Factor: MED8; motif: CYYNSCYYCCTSCNCC | 144 | 2.864452e-03 | 1 |
| TF | TF:M10432_1 | Factor: MAZ; motif: GGGMGGGGS; match class: 1 | Factor: MAZ; motif: GGGMGGGGS; match class: 1 | 68 | 3.240730e-03 | 1 |
| TF | TF:M03807_1 | Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 | Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 | 66 | 3.447301e-03 | 1 |
| TF | TF:M10086_1 | Factor: TAFII250; motif: RARRWGGCGGMGGNGR; match class: 1 | Factor: TAFII250; motif: RARRWGGCGGMGGNGR; match class: 1 | 63 | 3.896149e-03 | 1 |
| TF | TF:M02281 | Factor: SP1; motif: CCCCKCCCCC | Factor: SP1; motif: CCCCKCCCCC | 89 | 4.110789e-03 | 1 |
| TF | TF:M00986 | Factor: Churchill; motif: CGGGNN | Factor: Churchill; motif: CGGGNN | 154 | 4.425159e-03 | 1 |
| TF | TF:M12722 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS | 126 | 4.595754e-03 | 1 |
| TF | TF:M11601 | Factor: TCF-1; motif: ACATCGRGRCGCTGW | Factor: TCF-1; motif: ACATCGRGRCGCTGW | 158 | 4.601695e-03 | 1 |
| TF | TF:M09636 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG | 167 | 4.703490e-03 | 1 |
| TF | TF:M12158 | Factor: KLF15; motif: NCCMCGCCCMCN | Factor: KLF15; motif: NCCMCGCCCMCN | 125 | 5.001002e-03 | 1 |
| TF | TF:M10530_1 | Factor: sp4; motif: NNNGCYCCGCCCCCY; match class: 1 | Factor: sp4; motif: NNNGCYCCGCCCCCY; match class: 1 | 61 | 5.025304e-03 | 1 |
| TF | TF:M09898 | Factor: Egr-2; motif: GNGRRNGWGKGGGNGGRG | Factor: Egr-2; motif: GNGRRNGWGKGGGNGGRG | 89 | 5.045879e-03 | 1 |
| TF | TF:M13124_1 | Factor: ZNF670; motif: SNGGGCRGRG; match class: 1 | Factor: ZNF670; motif: SNGGGCRGRG; match class: 1 | 105 | 5.151648e-03 | 1 |
| TF | TF:M03893_1 | Factor: WT1; motif: GNGGGGGCGGGG; match class: 1 | Factor: WT1; motif: GNGGGGGCGGGG; match class: 1 | 63 | 5.449350e-03 | 1 |
| TF | TF:M11601_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 130 | 5.514774e-03 | 1 |
| TF | TF:M03896 | Factor: EGR1; motif: NACGCCCACGCANW | Factor: EGR1; motif: NACGCCCACGCANW | 85 | 5.562403e-03 | 1 |
| TF | TF:M10530 | Factor: sp4; motif: NNNGCYCCGCCCCCY | Factor: sp4; motif: NNNGCYCCGCCCCCY | 105 | 5.646646e-03 | 1 |
| TF | TF:M09603 | Factor: Egr-1; motif: NNNNNGYGKGGGNGGGNN | Factor: Egr-1; motif: NNNNNGYGKGGGNGGGNN | 70 | 5.977554e-03 | 1 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 170 | 6.340781e-03 | 1 |
| TF | TF:M08867 | Factor: AP2; motif: GCCYGSGGSN | Factor: AP2; motif: GCCYGSGGSN | 121 | 6.351317e-03 | 1 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 152 | 6.494961e-03 | 1 |
| TF | TF:M11603 | Factor: TCF-1; motif: ACATCGRGRCGCTGW | Factor: TCF-1; motif: ACATCGRGRCGCTGW | 167 | 6.546185e-03 | 1 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 159 | 7.035975e-03 | 1 |
| TF | TF:M00196_1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | 83 | 7.707292e-03 | 1 |
| TF | TF:M09859 | Factor: NF90; motif: NCCNCWGCCYCCNC | Factor: NF90; motif: NCCNCWGCCYCCNC | 70 | 8.125275e-03 | 1 |
| TF | TF:M12508_1 | Factor: EGR1; motif: NNMCGCCCACGCNN; match class: 1 | Factor: EGR1; motif: NNMCGCCCACGCNN; match class: 1 | 42 | 8.783702e-03 | 1 |
| TF | TF:M09765_1 | Factor: SP1; motif: NRGKGGGCGGGGCN; match class: 1 | Factor: SP1; motif: NRGKGGGCGGGGCN; match class: 1 | 55 | 9.110788e-03 | 1 |
| TF | TF:M02281_1 | Factor: SP1; motif: CCCCKCCCCC; match class: 1 | Factor: SP1; motif: CCCCKCCCCC; match class: 1 | 46 | 9.365704e-03 | 1 |
| TF | TF:M01858 | Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN | Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN | 97 | 9.721218e-03 | 1 |
| TF | TF:M07040_1 | Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1 | Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1 | 104 | 9.730110e-03 | 1 |
| TF | TF:M09984_1 | Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1 | Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1 | 79 | 1.036489e-02 | 1 |
| TF | TF:M00333_1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | 140 | 1.066844e-02 | 1 |
| TF | TF:M10435_1 | Factor: Sp2; motif: GGGGCGGGG; match class: 1 | Factor: Sp2; motif: GGGGCGGGG; match class: 1 | 57 | 1.143741e-02 | 1 |
| TF | TF:M09723_1 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 | 83 | 1.200938e-02 | 1 |
| TF | TF:M12227_1 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 | 82 | 1.202891e-02 | 1 |
| TF | TF:M07039 | Factor: ETF; motif: CCCCGCCCCYN | Factor: ETF; motif: CCCCGCCCCYN | 167 | 1.203868e-02 | 1 |
| TF | TF:M12160 | Factor: KLF15; motif: RCCMCRCCCMCN | Factor: KLF15; motif: RCCMCRCCCMCN | 142 | 1.270236e-02 | 1 |
| TF | TF:M07208_1 | Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 | Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 | 41 | 1.276219e-02 | 1 |
| TF | TF:M10108_1 | Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG; match class: 1 | Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG; match class: 1 | 49 | 1.402272e-02 | 1 |
| TF | TF:M12313 | Factor: ZNF460; motif: NNACNCCCCCCNN | Factor: ZNF460; motif: NNACNCCCCCCNN | 81 | 1.545427e-02 | 1 |
| TF | TF:M09892 | Factor: E2F-1; motif: NNNNGGCGGGAARN | Factor: E2F-1; motif: NNNNGGCGGGAARN | 148 | 1.547964e-02 | 1 |
| TF | TF:M13127 | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS | 138 | 1.549474e-02 | 1 |
| TF | TF:M12742 | Factor: ZNF93; motif: GGYAGCRGCAGCGGYG | Factor: ZNF93; motif: GGYAGCRGCAGCGGYG | 45 | 1.552824e-02 | 1 |
| TF | TF:M00244 | Factor: NGFI-C; motif: WTGCGTGGGYGG | Factor: NGFI-C; motif: WTGCGTGGGYGG | 84 | 1.650350e-02 | 1 |
| TF | TF:M09970 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN | 99 | 1.710111e-02 | 1 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 164 | 1.782698e-02 | 1 |
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 152 | 1.837578e-02 | 1 |
| TF | TF:M11603_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 145 | 1.839581e-02 | 1 |
| TF | TF:M07397_1 | Factor: ZBP89; motif: CCCCKCCCCCNN; match class: 1 | Factor: ZBP89; motif: CCCCKCCCCCNN; match class: 1 | 50 | 1.851672e-02 | 1 |
| TF | TF:M07226 | Factor: SP1; motif: NCCCCKCCCCC | Factor: SP1; motif: NCCCCKCCCCC | 104 | 1.884152e-02 | 1 |
| TF | TF:M09658 | Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS | Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS | 75 | 1.981690e-02 | 1 |
| TF | TF:M09738 | Factor: ZNF511; motif: GGRRGRGGCWGNG | Factor: ZNF511; motif: GGRRGRGGCWGNG | 126 | 2.214066e-02 | 1 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 157 | 2.383574e-02 | 1 |
| TF | TF:M12597 | Factor: E2F1; motif: GSGCGGGAAN | Factor: E2F1; motif: GSGCGGGAAN | 151 | 2.422748e-02 | 1 |
| TF | TF:M09765 | Factor: SP1; motif: NRGKGGGCGGGGCN | Factor: SP1; motif: NRGKGGGCGGGGCN | 96 | 2.745002e-02 | 1 |
| TF | TF:M12183 | Factor: KLF14; motif: NRCCACRCCCMCN | Factor: KLF14; motif: NRCCACRCCCMCN | 90 | 2.864741e-02 | 1 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 162 | 3.080579e-02 | 1 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 159 | 3.133687e-02 | 1 |
| TF | TF:M07289 | Factor: GKLF; motif: NNNRGGNGNGGSN | Factor: GKLF; motif: NNNRGGNGNGGSN | 155 | 3.259534e-02 | 1 |
| TF | TF:M00008_1 | Factor: Sp1; motif: GGGGCGGGGT; match class: 1 | Factor: Sp1; motif: GGGGCGGGGT; match class: 1 | 71 | 3.292012e-02 | 1 |
| TF | TF:M00915 | Factor: AP-2; motif: SNNNCCNCAGGCN | Factor: AP-2; motif: SNNNCCNCAGGCN | 115 | 3.371217e-02 | 1 |
| TF | TF:M12351 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | 137 | 3.487075e-02 | 1 |
| TF | TF:M13135 | Factor: SP4; motif: GGCCCCGCCCCCN | Factor: SP4; motif: GGCCCCGCCCCCN | 77 | 3.893827e-02 | 1 |
| TF | TF:M00427 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 114 | 4.021491e-02 | 1 |
| TF | TF:M09897_1 | Factor: Egr-1; motif: NNNNGCGKGGGYGGNRN; match class: 1 | Factor: Egr-1; motif: NNNNGCGKGGGYGGNRN; match class: 1 | 24 | 4.158867e-02 | 1 |
| TF | TF:M13144 | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS | 113 | 4.182604e-02 | 1 |
| TF | TF:M09970_1 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 | 58 | 4.385485e-02 | 1 |
| TF | TF:M09894 | Factor: E2F-4; motif: SNGGGCGGGAANN | Factor: E2F-4; motif: SNGGGCGGGAANN | 165 | 4.486027e-02 | 1 |
| TF | TF:M07063_1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | 44 | 4.534607e-02 | 1 |
| TF | TF:M12590_1 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1 | 88 | 4.769082e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 125 | 1.320928e-09 | 1 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 126 | 1.096350e-08 | 1 |
| HPA | HPA:0050000 | Breast | Breast | 123 | 2.331181e-08 | 1 |
| HPA | HPA:0130000 | Colon | Colon | 132 | 4.952591e-08 | 1 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 118 | 1.818773e-07 | 1 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 119 | 1.910836e-07 | 1 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 122 | 6.956656e-07 | 1 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 122 | 6.956656e-07 | 1 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 121 | 1.671709e-06 | 1 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 121 | 1.671709e-06 | 1 |
| HPA | HPA:0400000 | Rectum | Rectum | 127 | 1.755131e-06 | 1 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 104 | 1.771414e-06 | 1 |
| HPA | HPA:0130052 | Colon; glandular cells[≥Medium] | Colon; glandular cells[≥Medium] | 107 | 2.934665e-06 | 1 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 120 | 2.957868e-06 | 1 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 123 | 5.108852e-06 | 1 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 123 | 5.108852e-06 | 1 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 121 | 5.963886e-06 | 1 |
| HPA | HPA:0380000 | Placenta | Placenta | 122 | 6.174623e-06 | 1 |
| HPA | HPA:0340000 | Ovary | Ovary | 100 | 6.353173e-06 | 1 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 123 | 9.409658e-06 | 1 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 123 | 9.409658e-06 | 1 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 102 | 1.178058e-05 | 1 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 115 | 1.998154e-05 | 1 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 115 | 1.998154e-05 | 1 |
| HPA | HPA:0130202 | Colon; endothelial cells[≥Medium] | Colon; endothelial cells[≥Medium] | 77 | 2.004925e-05 | 1 |
| HPA | HPA:0030000 | Appendix | Appendix | 124 | 2.022210e-05 | 1 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 99 | 2.148363e-05 | 1 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 113 | 2.418170e-05 | 1 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 117 | 2.685041e-05 | 1 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 117 | 2.685041e-05 | 1 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 124 | 3.416580e-05 | 1 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 122 | 3.453276e-05 | 1 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 122 | 3.453276e-05 | 1 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 112 | 4.184268e-05 | 1 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 112 | 4.184268e-05 | 1 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 123 | 4.339316e-05 | 1 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 100 | 5.480038e-05 | 1 |
| HPA | HPA:0130051 | Colon; glandular cells[≥Low] | Colon; glandular cells[≥Low] | 115 | 5.803199e-05 | 1 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 119 | 6.940450e-05 | 1 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 119 | 7.500919e-05 | 1 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 113 | 7.514559e-05 | 1 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 113 | 7.514559e-05 | 1 |
| HPA | HPA:0030051 | Appendix; glandular cells[≥Low] | Appendix; glandular cells[≥Low] | 112 | 9.221555e-05 | 1 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 101 | 1.024995e-04 | 1 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 99 | 1.074196e-04 | 1 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 115 | 1.118454e-04 | 1 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 100 | 1.129491e-04 | 1 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 82 | 1.198881e-04 | 1 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 125 | 1.280546e-04 | 1 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 123 | 1.497294e-04 | 1 |
| HPA | HPA:0270000 | Kidney | Kidney | 126 | 1.536645e-04 | 1 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 110 | 2.304264e-04 | 1 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 102 | 3.066802e-04 | 1 |
| HPA | HPA:0400051 | Rectum; glandular cells[≥Low] | Rectum; glandular cells[≥Low] | 114 | 3.358896e-04 | 1 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 109 | 4.125684e-04 | 1 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 105 | 4.400098e-04 | 1 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 105 | 4.400098e-04 | 1 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 99 | 4.898417e-04 | 1 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 111 | 5.060460e-04 | 1 |
| HPA | HPA:0150051 | Duodenum; glandular cells[≥Low] | Duodenum; glandular cells[≥Low] | 114 | 5.238269e-04 | 1 |
| HPA | HPA:0630000 | Cervix | Cervix | 112 | 5.678905e-04 | 1 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 113 | 6.580859e-04 | 1 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 112 | 6.816548e-04 | 1 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 94 | 7.588235e-04 | 1 |
| HPA | HPA:0480052 | Small intestine; glandular cells[≥Medium] | Small intestine; glandular cells[≥Medium] | 102 | 9.457290e-04 | 1 |
| HPA | HPA:0480051 | Small intestine; glandular cells[≥Low] | Small intestine; glandular cells[≥Low] | 113 | 1.034894e-03 | 1 |
| HPA | HPA:0300000 | Lung | Lung | 116 | 1.084070e-03 | 1 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 101 | 1.150244e-03 | 1 |
| HPA | HPA:0620000 | Vagina | Vagina | 101 | 1.150244e-03 | 1 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 76 | 1.175764e-03 | 1 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 91 | 1.257342e-03 | 1 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 104 | 1.368438e-03 | 1 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 90 | 1.507193e-03 | 1 |
| HPA | HPA:0290000 | Liver | Liver | 104 | 1.552913e-03 | 1 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 84 | 1.618821e-03 | 1 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 87 | 1.649337e-03 | 1 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 91 | 1.795133e-03 | 1 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 86 | 1.905597e-03 | 1 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 87 | 1.933417e-03 | 1 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 116 | 2.027224e-03 | 1 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 99 | 2.162477e-03 | 1 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 99 | 2.162477e-03 | 1 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 85 | 2.280794e-03 | 1 |
| HPA | HPA:0400052 | Rectum; glandular cells[≥Medium] | Rectum; glandular cells[≥Medium] | 101 | 3.128222e-03 | 1 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 113 | 3.240313e-03 | 1 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 87 | 3.306779e-03 | 1 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 89 | 5.266242e-03 | 1 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 93 | 6.257912e-03 | 1 |
| HPA | HPA:0150052 | Duodenum; glandular cells[≥Medium] | Duodenum; glandular cells[≥Medium] | 100 | 6.938555e-03 | 1 |
| HPA | HPA:0130241 | Colon; peripheral nerve/ganglion[≥Low] | Colon; peripheral nerve/ganglion[≥Low] | 87 | 7.925752e-03 | 1 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 73 | 9.168380e-03 | 1 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 82 | 1.117534e-02 | 1 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 102 | 1.303117e-02 | 1 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 91 | 1.713382e-02 | 1 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 91 | 1.713382e-02 | 1 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 89 | 1.941066e-02 | 1 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 74 | 2.069376e-02 | 1 |
| HPA | HPA:0390000 | Prostate | Prostate | 105 | 2.177996e-02 | 1 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 105 | 2.177996e-02 | 1 |
| HPA | HPA:0460661 | Skin 1; keratinocytes[≥Low] | Skin 1; keratinocytes[≥Low] | 87 | 2.245551e-02 | 1 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 43 | 2.486778e-02 | 1 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 103 | 2.861143e-02 | 1 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 101 | 2.961100e-02 | 1 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 85 | 3.543391e-02 | 1 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 98 | 3.630816e-02 | 1 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 23 | 3.778363e-02 | 1 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 83 | 4.342836e-02 | 1 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 97 | 4.419116e-02 | 1 |
| HPA | HPA:0100211 | Cerebral cortex; neuropil[≥Low] | Cerebral cortex; neuropil[≥Low] | 84 | 4.739545e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-548ah | hsa-mir-548ah | hsa-mir-548ah | 47 | 1.910113e-09 | 1 |
| MIRNA | MIRNA:hsa-mir-141 | hsa-mir-141 | hsa-mir-141 | 46 | 5.287586e-09 | 1 |
| MIRNA | MIRNA:hsa-mir-200a | hsa-mir-200a | hsa-mir-200a | 46 | 5.287586e-09 | 1 |
| MIRNA | MIRNA:hsa-mir-3609 | hsa-mir-3609 | hsa-mir-3609 | 48 | 5.430332e-09 | 1 |
| MIRNA | MIRNA:hsa-mir-582-5p | hsa-mir-582-5p | hsa-mir-582-5p | 43 | 4.778882e-08 | 1 |
| MIRNA | MIRNA:hsa-mir-410 | hsa-mir-410 | hsa-mir-410 | 37 | 2.193219e-07 | 1 |
| MIRNA | MIRNA:hsa-mir-4796-3p | hsa-mir-4796-3p | hsa-mir-4796-3p | 40 | 1.901399e-06 | 1 |
| MIRNA | MIRNA:hsa-mir-548aa | hsa-mir-548aa | hsa-mir-548aa | 44 | 3.416119e-06 | 1 |
| MIRNA | MIRNA:hsa-mir-340 | hsa-mir-340 | hsa-mir-340 | 42 | 4.870064e-06 | 1 |
| MIRNA | MIRNA:hsa-mir-139-5p | hsa-mir-139-5p | hsa-mir-139-5p | 32 | 7.530118e-06 | 1 |
| MIRNA | MIRNA:hsa-mir-106b-5p | hsa-mir-106b-5p | hsa-mir-106b-5p | 32 | 1.548346e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-4801 | hsa-mir-4801 | hsa-mir-4801 | 39 | 1.595558e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-4731-3p | hsa-mir-4731-3p | hsa-mir-4731-3p | 39 | 1.625740e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-503 | hsa-mir-503 | hsa-mir-503 | 28 | 2.235333e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-548z | hsa-mir-548z | hsa-mir-548z | 45 | 2.344327e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-548ac | hsa-mir-548ac | hsa-mir-548ac | 45 | 2.344327e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-548d-3p | hsa-mir-548d-3p | hsa-mir-548d-3p | 45 | 2.541109e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-577 | hsa-mir-577 | hsa-mir-577 | 32 | 2.592686e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-664 | hsa-mir-664 | hsa-mir-664 | 36 | 2.687904e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-4666-3p | hsa-mir-4666-3p | hsa-mir-4666-3p | 39 | 3.574824e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-3942-3p | hsa-mir-3942-3p | hsa-mir-3942-3p | 39 | 3.909166e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-548c-3p | hsa-mir-548c-3p | hsa-mir-548c-3p | 63 | 4.371473e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-4276 | hsa-mir-4276 | hsa-mir-4276 | 34 | 4.692635e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-93-5p | hsa-mir-93-5p | hsa-mir-93-5p | 33 | 5.279311e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-3119 | hsa-mir-3119 | hsa-mir-3119 | 33 | 5.388568e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-299-5p | hsa-mir-299-5p | hsa-mir-299-5p | 24 | 5.736282e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 35 | 6.575536e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-144 | hsa-mir-144 | hsa-mir-144 | 38 | 7.362376e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-3163 | hsa-mir-3163 | hsa-mir-3163 | 53 | 1.317769e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-524-5p | hsa-mir-524-5p | hsa-mir-524-5p | 47 | 1.387614e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-520d-5p | hsa-mir-520d-5p | hsa-mir-520d-5p | 47 | 1.407392e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-363 | hsa-mir-363 | hsa-mir-363 | 34 | 1.706839e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-25 | hsa-mir-25 | hsa-mir-25 | 34 | 1.706839e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-32 | hsa-mir-32 | hsa-mir-32 | 34 | 1.706839e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-367 | hsa-mir-367 | hsa-mir-367 | 34 | 1.706839e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-92b | hsa-mir-92b | hsa-mir-92b | 34 | 1.706839e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-92a | hsa-mir-92a | hsa-mir-92a | 34 | 1.706839e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-3160-5p | hsa-mir-3160-5p | hsa-mir-3160-5p | 31 | 1.789506e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-4672 | hsa-mir-4672 | hsa-mir-4672 | 38 | 1.825635e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-3662 | hsa-mir-3662 | hsa-mir-3662 | 49 | 2.060528e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-17-5p | hsa-mir-17-5p | hsa-mir-17-5p | 31 | 2.768987e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-4668-5p | hsa-mir-4668-5p | hsa-mir-4668-5p | 44 | 3.344526e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-186 | hsa-mir-186 | hsa-mir-186 | 39 | 3.548863e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-570 | hsa-mir-570 | hsa-mir-570 | 43 | 3.667927e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-30d | hsa-mir-30d | hsa-mir-30d | 34 | 4.267746e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-30e | hsa-mir-30e | hsa-mir-30e | 34 | 4.267746e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-30b | hsa-mir-30b | hsa-mir-30b | 34 | 4.267746e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-30a | hsa-mir-30a | hsa-mir-30a | 34 | 4.267746e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-30c | hsa-mir-30c | hsa-mir-30c | 34 | 4.267746e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-9 | hsa-mir-9 | hsa-mir-9 | 29 | 4.603763e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-101 | hsa-mir-101 | hsa-mir-101 | 34 | 5.075780e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-3692 | hsa-mir-3692 | hsa-mir-3692 | 33 | 5.767170e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-7 | hsa-mir-7 | hsa-mir-7 | 32 | 6.050584e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-4698 | hsa-mir-4698 | hsa-mir-4698 | 44 | 6.092514e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-3613-3p | hsa-mir-3613-3p | hsa-mir-3613-3p | 56 | 6.258086e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-548b-3p | hsa-mir-548b-3p | hsa-mir-548b-3p | 25 | 6.324835e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-548aj | hsa-mir-548aj | hsa-mir-548aj | 41 | 6.342148e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-548ae | hsa-mir-548ae | hsa-mir-548ae | 41 | 6.342148e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-548x | hsa-mir-548x | hsa-mir-548x | 41 | 6.342148e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-548am | hsa-mir-548am | hsa-mir-548am | 41 | 6.342148e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-195 | hsa-mir-195 | hsa-mir-195 | 44 | 6.523456e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-16 | hsa-mir-16 | hsa-mir-16 | 44 | 6.523456e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-15b | hsa-mir-15b | hsa-mir-15b | 44 | 6.523456e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-497 | hsa-mir-497 | hsa-mir-497 | 44 | 6.523456e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-424 | hsa-mir-424 | hsa-mir-424 | 44 | 6.523456e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-15a | hsa-mir-15a | hsa-mir-15a | 44 | 6.523456e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-545 | hsa-mir-545 | hsa-mir-545 | 39 | 6.556556e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 27 | 6.589478e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-4729 | hsa-mir-4729 | hsa-mir-4729 | 41 | 6.816821e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-3658 | hsa-mir-3658 | hsa-mir-3658 | 36 | 8.139324e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-3685 | hsa-mir-3685 | hsa-mir-3685 | 28 | 1.092965e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-488 | hsa-mir-488 | hsa-mir-488 | 30 | 1.101320e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-3148 | hsa-mir-3148 | hsa-mir-3148 | 46 | 1.105621e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-20a-5p | hsa-mir-20a-5p | hsa-mir-20a-5p | 28 | 1.252142e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 20 | 1.298213e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-3646 | hsa-mir-3646 | hsa-mir-3646 | 42 | 1.432756e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-548t | hsa-mir-548t | hsa-mir-548t | 37 | 1.447944e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-3919 | hsa-mir-3919 | hsa-mir-3919 | 39 | 1.645137e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-338-5p | hsa-mir-338-5p | hsa-mir-338-5p | 33 | 1.845218e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-127-5p | hsa-mir-127-5p | hsa-mir-127-5p | 24 | 1.858386e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-519d-3p | hsa-mir-519d-3p | hsa-mir-519d-3p | 25 | 1.959810e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-659 | hsa-mir-659 | hsa-mir-659 | 26 | 2.317613e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-20b-5p | hsa-mir-20b-5p | hsa-mir-20b-5p | 25 | 2.359847e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-93 | hsa-mir-93 | hsa-mir-93 | 42 | 2.401198e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-20a | hsa-mir-20a | hsa-mir-20a | 42 | 2.401198e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-106a | hsa-mir-106a | hsa-mir-106a | 42 | 2.401198e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-519d | hsa-mir-519d | hsa-mir-519d | 42 | 2.401198e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-17 | hsa-mir-17 | hsa-mir-17 | 42 | 2.401198e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-106b | hsa-mir-106b | hsa-mir-106b | 42 | 2.401198e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-20b | hsa-mir-20b | hsa-mir-20b | 42 | 2.401198e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-1290 | hsa-mir-1290 | hsa-mir-1290 | 28 | 2.465953e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-543 | hsa-mir-543 | hsa-mir-543 | 36 | 2.558217e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-142-5p | hsa-mir-142-5p | hsa-mir-142-5p | 33 | 2.581051e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-361-5p | hsa-mir-361-5p | hsa-mir-361-5p | 26 | 2.711704e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-3160-3p | hsa-mir-3160-3p | hsa-mir-3160-3p | 30 | 2.714384e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-203 | hsa-mir-203 | hsa-mir-203 | 35 | 2.808047e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-548v | hsa-mir-548v | hsa-mir-548v | 25 | 2.833627e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-4427 | hsa-mir-4427 | hsa-mir-4427 | 28 | 2.853227e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-494 | hsa-mir-494 | hsa-mir-494 | 37 | 3.650601e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-153 | hsa-mir-153 | hsa-mir-153 | 22 | 5.011020e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-4302 | hsa-mir-4302 | hsa-mir-4302 | 30 | 5.033625e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-514b-5p | hsa-mir-514b-5p | hsa-mir-514b-5p | 29 | 6.342518e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-513c | hsa-mir-513c | hsa-mir-513c | 28 | 6.616648e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-155-5p | hsa-mir-155-5p | hsa-mir-155-5p | 24 | 6.793168e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-3671 | hsa-mir-3671 | hsa-mir-3671 | 36 | 6.795768e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-107 | hsa-mir-107 | hsa-mir-107 | 36 | 7.079565e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-4422 | hsa-mir-4422 | hsa-mir-4422 | 34 | 7.292149e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-4524 | hsa-mir-4524 | hsa-mir-4524 | 25 | 7.601403e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-1285 | hsa-mir-1285 | hsa-mir-1285 | 38 | 8.634017e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-579 | hsa-mir-579 | hsa-mir-579 | 40 | 9.099501e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-181b | hsa-mir-181b | hsa-mir-181b | 36 | 9.520047e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-181d | hsa-mir-181d | hsa-mir-181d | 36 | 9.520047e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-181c | hsa-mir-181c | hsa-mir-181c | 36 | 9.520047e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-4652-3p | hsa-mir-4652-3p | hsa-mir-4652-3p | 35 | 9.567445e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-181a | hsa-mir-181a | hsa-mir-181a | 36 | 9.647551e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-103a | hsa-mir-103a | hsa-mir-103a | 34 | 9.663123e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-4677-5p | hsa-mir-4677-5p | hsa-mir-4677-5p | 27 | 9.781734e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-3942-5p | hsa-mir-3942-5p | hsa-mir-3942-5p | 25 | 1.000675e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3134 | hsa-mir-3134 | hsa-mir-3134 | 20 | 1.004322e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4703-5p | hsa-mir-4703-5p | hsa-mir-4703-5p | 25 | 1.037518e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3619-5p | hsa-mir-3619-5p | hsa-mir-3619-5p | 41 | 1.085144e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-330-3p | hsa-mir-330-3p | hsa-mir-330-3p | 34 | 1.094621e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-761 | hsa-mir-761 | hsa-mir-761 | 41 | 1.111297e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4511 | hsa-mir-4511 | hsa-mir-4511 | 26 | 1.116254e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4311 | hsa-mir-4311 | hsa-mir-4311 | 33 | 1.300172e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-19a | hsa-mir-19a | hsa-mir-19a | 29 | 1.322728e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-19b | hsa-mir-19b | hsa-mir-19b | 29 | 1.322728e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3120-3p | hsa-mir-3120-3p | hsa-mir-3120-3p | 38 | 1.394593e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-300 | hsa-mir-300 | hsa-mir-300 | 32 | 1.582697e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-548n | hsa-mir-548n | hsa-mir-548n | 37 | 1.606507e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-384 | hsa-mir-384 | hsa-mir-384 | 26 | 1.678395e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-194 | hsa-mir-194 | hsa-mir-194 | 25 | 1.730330e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4262 | hsa-mir-4262 | hsa-mir-4262 | 36 | 1.821363e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4527 | hsa-mir-4527 | hsa-mir-4527 | 19 | 1.828799e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-214 | hsa-mir-214 | hsa-mir-214 | 40 | 1.844784e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3146 | hsa-mir-3146 | hsa-mir-3146 | 16 | 1.850310e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-708 | hsa-mir-708 | hsa-mir-708 | 22 | 1.967620e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-450b-5p | hsa-mir-450b-5p | hsa-mir-450b-5p | 32 | 2.032880e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3187-5p | hsa-mir-3187-5p | hsa-mir-3187-5p | 38 | 2.060549e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-612 | hsa-mir-612 | hsa-mir-612 | 38 | 2.136049e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-646 | hsa-mir-646 | hsa-mir-646 | 34 | 2.140687e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-151-3p | hsa-mir-151-3p | hsa-mir-151-3p | 16 | 2.166625e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3921 | hsa-mir-3921 | hsa-mir-3921 | 27 | 2.178206e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3065-5p | hsa-mir-3065-5p | hsa-mir-3065-5p | 33 | 2.182738e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4653-5p | hsa-mir-4653-5p | hsa-mir-4653-5p | 27 | 2.212802e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-381 | hsa-mir-381 | hsa-mir-381 | 31 | 2.242668e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4659a-3p | hsa-mir-4659a-3p | hsa-mir-4659a-3p | 39 | 2.277176e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4659b-3p | hsa-mir-4659b-3p | hsa-mir-4659b-3p | 39 | 2.277176e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-21-5p | hsa-mir-21-5p | hsa-mir-21-5p | 18 | 2.318581e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4766-5p | hsa-mir-4766-5p | hsa-mir-4766-5p | 32 | 2.427830e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4699-3p | hsa-mir-4699-3p | hsa-mir-4699-3p | 33 | 2.459769e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-371-5p | hsa-mir-371-5p | hsa-mir-371-5p | 37 | 2.530427e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4328 | hsa-mir-4328 | hsa-mir-4328 | 37 | 2.561102e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4282 | hsa-mir-4282 | hsa-mir-4282 | 43 | 2.562800e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-103b | hsa-mir-103b | hsa-mir-103b | 17 | 2.580340e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3139 | hsa-mir-3139 | hsa-mir-3139 | 22 | 2.660863e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3973 | hsa-mir-3973 | hsa-mir-3973 | 31 | 2.723903e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4521 | hsa-mir-4521 | hsa-mir-4521 | 19 | 2.765033e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-548an | hsa-mir-548an | hsa-mir-548an | 32 | 2.815508e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-324-3p | hsa-mir-324-3p | hsa-mir-324-3p | 33 | 2.916959e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4642 | hsa-mir-4642 | hsa-mir-4642 | 23 | 2.968928e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4424 | hsa-mir-4424 | hsa-mir-4424 | 20 | 3.026843e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-1279 | hsa-mir-1279 | hsa-mir-1279 | 24 | 3.067004e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-544 | hsa-mir-544 | hsa-mir-544 | 28 | 3.312832e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4445 | hsa-mir-4445 | hsa-mir-4445 | 17 | 3.425854e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-648 | hsa-mir-648 | hsa-mir-648 | 18 | 3.625328e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-548p | hsa-mir-548p | hsa-mir-548p | 35 | 3.655172e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4680-3p | hsa-mir-4680-3p | hsa-mir-4680-3p | 27 | 3.676216e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4756-3p | hsa-mir-4756-3p | hsa-mir-4756-3p | 30 | 3.744061e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3156-5p | hsa-mir-3156-5p | hsa-mir-3156-5p | 18 | 3.786603e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-138 | hsa-mir-138 | hsa-mir-138 | 23 | 3.789927e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-193a-3p | hsa-mir-193a-3p | hsa-mir-193a-3p | 21 | 3.804435e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-326 | hsa-mir-326 | hsa-mir-326 | 30 | 3.901378e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3200-3p | hsa-mir-3200-3p | hsa-mir-3200-3p | 15 | 3.944525e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-28-5p | hsa-mir-28-5p | hsa-mir-28-5p | 22 | 4.116597e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-548ag | hsa-mir-548ag | hsa-mir-548ag | 22 | 4.116597e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-548ai | hsa-mir-548ai | hsa-mir-548ai | 22 | 4.116597e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-301a | hsa-mir-301a | hsa-mir-301a | 28 | 4.242231e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-454 | hsa-mir-454 | hsa-mir-454 | 28 | 4.242231e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-130b | hsa-mir-130b | hsa-mir-130b | 28 | 4.242231e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-301b | hsa-mir-301b | hsa-mir-301b | 28 | 4.242231e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-130a | hsa-mir-130a | hsa-mir-130a | 28 | 4.242231e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-2116 | hsa-mir-2116 | hsa-mir-2116 | 23 | 4.345911e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-362-5p | hsa-mir-362-5p | hsa-mir-362-5p | 19 | 4.456810e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3614-5p | hsa-mir-3614-5p | hsa-mir-3614-5p | 31 | 4.483208e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4778-5p | hsa-mir-4778-5p | hsa-mir-4778-5p | 27 | 4.594683e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3688-3p | hsa-mir-3688-3p | hsa-mir-3688-3p | 28 | 4.756494e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-409-5p | hsa-mir-409-5p | hsa-mir-409-5p | 14 | 4.802937e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-720 | hsa-mir-720 | hsa-mir-720 | 14 | 4.936164e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3617 | hsa-mir-3617 | hsa-mir-3617 | 28 | 4.963456e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5376 | 17p13 3 YWHAE copy number variation | 17p13 3 YWHAE copy number variation | 7 | 3.543284e-07 | 1 |
| WP | WP:WP4560 | MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement | MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement | 6 | 5.368718e-06 | 1 |
| WP | WP:WP4534 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms | 6 | 2.091868e-03 | 1 |
| WP | WP:WP5502 | 16p13 11 copy number variation syndrome | 16p13 11 copy number variation syndrome | 5 | 2.841920e-03 | 1 |
| WP | WP:WP51 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 9 | 8.113598e-03 | 1 |
| WP | WP:WP2572 | Primary focal segmental glomerulosclerosis FSGS | Primary focal segmental glomerulosclerosis FSGS | 6 | 2.746667e-02 | 1 |
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 7 | 4.728835e-02 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 12 | 0.000002 | 1 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | Bacterial invasion of epithelial cells | 9 | 0.000003 | 1 |
| KEGG | KEGG:04520 | Adherens junction | Adherens junction | 8 | 0.000208 | 1 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | Leukocyte transendothelial migration | 8 | 0.000958 | 1 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 11 | 0.001549 | 1 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 10 | 0.004382 | 1 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | Rap1 signaling pathway | 9 | 0.013222 | 1 |
| KEGG | KEGG:04814 | Motor proteins | Motor proteins | 8 | 0.039416 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5177 | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | 4 | 0.000572 | 1 |
| CORUM | CORUM:5199 | Kinase maturation complex 1 | Kinase maturation complex 1 | 4 | 0.026102 | 1 |
| CORUM | CORUM:6925 | MAPK1-PTK2-PXN complex | MAPK1-PTK2-PXN complex | 2 | 0.049944 | 1 |
| CORUM | CORUM:7345 | DISC1-TRAK1 complex | DISC1-TRAK1 complex | 2 | 0.049944 | 1 |
| CORUM | CORUM:5282 | CAS-SRC-FAK complex | CAS-SRC-FAK complex | 2 | 0.049944 | 1 |
| CORUM | CORUM:6916 | CTTN-FER-PTK2 complex | CTTN-FER-PTK2 complex | 2 | 0.049944 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0030192 | Fatigable weakness of bulbar muscles | A type of weakness of the bulbar muscles (muscles of the mouth and throat responsible for speech and swallowing) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions. | 7 | 0.010083 | 1 |
| HP | HP:0001283 | Bulbar palsy | Bulbar weakness (or bulbar palsy) refers to bilateral impairment of function of the lower cranial nerves IX, X, XI and XII, which occurs due to lower motor neuron lesion either at nuclear or fascicular level in the medulla or from bilateral lesions of the lower cranial nerves outside the brain-stem. Bulbar weakness is often associated with difficulty in chewing, weakness of the facial muscles, dysarthria, palatal weakness and regurgitation of fluids, dysphagia, and dysphonia. | 6 | 0.013253 | 1 |
| HP | HP:0003473 | Fatigable weakness | A type of weakness that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions. | 9 | 0.015853 | 1 |
| HP | HP:0003398 | Abnormal synaptic transmission at the neuromuscular junction | Any abnormality of the neuromuscular junction, which is the synapse between the motor end plate of a motor neuron and the skeletal muscle fibers. | 9 | 0.016967 | 1 |
| HP | HP:0030191 | Abnormal peripheral nervous system synaptic transmission | An anomaly in the communication from a neuron to a target across a synapse in the peripheral nervous system. | 9 | 0.016967 | 1 |
| HP | HP:0012535 | Abnormal synaptic transmission | An anomaly in the communication from a neuron to a target across a synapse. This is a four step process, comprising (i) synthesis and storage of neurotransmitters; (ii) neurotransmitter release; (iii) activation of postsynaptic receptors by the neurotransmitter; and (iv) inactivation of the neurotransmitter. Thus, this term is defined as an anomaly of neurotransmitter metabolic process. | 9 | 0.016967 | 1 |
| HP | HP:0002145 | Frontotemporal dementia | A dementia associated with degeneration of the frontotemporal lobe and clinically associated with personality and behavioral changes such as disinhibition, apathy, and lack of insight. The hallmark feature of frontotemporal dementia is the presentation with focal syndromes such as progressive language dysfunction, or aphasia, or behavioral changes characteristic of frontal lobe disorders. | 6 | 0.037262 | 1 |
| HP | HP:0002450 | Abnormal motor neuron morphology | Any structural anomaly that affects the motor neuron. | 7 | 0.040234 | 1 |
| HP | HP:0012473 | Tongue atrophy | Wasting of the tongue. | 6 | 0.041838 | 1 |
| HP | HP:0012764 | Orthopnea | A sensation of breathlessness in the recumbent position, relieved by sitting or standing. | 8 | 0.049174 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 147 | 2.274198e-19 | 2 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 96 | 5.518203e-18 | 2 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 56 | 6.373946e-16 | 2 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 56 | 1.215074e-15 | 2 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 56 | 1.241240e-15 | 2 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 56 | 1.241240e-15 | 2 |
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 51 | 6.514916e-15 | 2 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 75 | 6.101672e-14 | 2 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 60 | 1.151756e-09 | 2 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 159 | 4.197217e-09 | 2 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 148 | 8.508796e-08 | 2 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 87 | 1.172451e-07 | 2 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 87 | 1.172451e-07 | 2 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 87 | 1.172451e-07 | 2 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 153 | 1.914473e-07 | 2 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 62 | 3.875878e-06 | 2 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 43 | 3.362746e-05 | 2 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 43 | 3.593903e-05 | 2 |
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 17 | 7.686323e-05 | 2 |
| GO:CC | GO:0099073 | mitochondrion-derived vesicle | "A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:18207745, PMID:20619655, PMID:22226745, PMID:23300790] | 3 | 1.207898e-04 | 2 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 63 | 2.555657e-04 | 2 |
| GO:CC | GO:0031090 | organelle membrane | "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] | 53 | 4.439471e-04 | 2 |
| GO:CC | GO:0005662 | DNA replication factor A complex | "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] | 4 | 5.889554e-04 | 2 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 134 | 8.900917e-04 | 2 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 14 | 1.003535e-03 | 2 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 14 | 1.310676e-03 | 2 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 141 | 3.335175e-03 | 2 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 20 | 3.743298e-03 | 2 |
| GO:CC | GO:0005777 | peroxisome | "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] | 8 | 3.882203e-03 | 2 |
| GO:CC | GO:0042579 | microbody | "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732] | 8 | 3.882203e-03 | 2 |
| GO:CC | GO:0005740 | mitochondrial envelope | "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] | 19 | 4.096906e-03 | 2 |
| GO:CC | GO:0043601 | nuclear replisome | "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] | 4 | 5.723692e-03 | 2 |
| GO:CC | GO:0031966 | mitochondrial membrane | "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] | 18 | 6.380451e-03 | 2 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 7 | 6.604082e-03 | 2 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 7 | 6.604082e-03 | 2 |
| GO:CC | GO:0140534 | endoplasmic reticulum protein-containing complex | "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] | 7 | 7.392962e-03 | 2 |
| GO:CC | GO:0030894 | replisome | "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] | 4 | 8.220130e-03 | 2 |
| GO:CC | GO:0048471 | perinuclear region of cytoplasm | "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] | 17 | 1.095959e-02 | 2 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 7 | 1.136678e-02 | 2 |
| GO:CC | GO:0031967 | organelle envelope | "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] | 24 | 1.177699e-02 | 2 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 35 | 1.574061e-02 | 2 |
| GO:CC | GO:1902687 | glucosidase complex | "A protein complex which is capable of glucosidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932] | 2 | 1.671957e-02 | 2 |
| GO:CC | GO:0017177 | glucosidase II complex | "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335] | 2 | 1.671957e-02 | 2 |
| GO:CC | GO:0098588 | bounding membrane of organelle | "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] | 33 | 2.431502e-02 | 2 |
| GO:CC | GO:0035861 | site of double-strand break | "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] | 6 | 2.651181e-02 | 2 |
| GO:CC | GO:0030126 | COPI vesicle coat | "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894] | 3 | 3.273271e-02 | 2 |
| GO:CC | GO:1990204 | oxidoreductase complex | "Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432] | 7 | 3.341540e-02 | 2 |
| GO:CC | GO:0031903 | microbody membrane | "The lipid bilayer surrounding a microbody." [GOC:mah] | 5 | 4.144651e-02 | 2 |
| GO:CC | GO:0005778 | peroxisomal membrane | "The lipid bilayer surrounding a peroxisome." [GOC:mah] | 5 | 4.144651e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006753 | nucleoside phosphate metabolic process | "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] | 31 | 1.748125e-13 | 2 |
| GO:BP | GO:0055086 | nucleobase-containing small molecule metabolic process | "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] | 31 | 5.453225e-13 | 2 |
| GO:BP | GO:0072521 | purine-containing compound metabolic process | "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 27 | 2.145759e-11 | 2 |
| GO:BP | GO:0009117 | nucleotide metabolic process | "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] | 25 | 6.512361e-11 | 2 |
| GO:BP | GO:0019637 | organophosphate metabolic process | "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] | 35 | 1.891055e-10 | 2 |
| GO:BP | GO:0006163 | purine nucleotide metabolic process | "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 23 | 2.475741e-10 | 2 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 55 | 5.238152e-10 | 2 |
| GO:BP | GO:0044281 | small molecule metabolic process | "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] | 44 | 9.209006e-10 | 2 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 43 | 1.068606e-08 | 2 |
| GO:BP | GO:0019693 | ribose phosphate metabolic process | "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 20 | 1.457738e-08 | 2 |
| GO:BP | GO:1901135 | carbohydrate derivative metabolic process | "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] | 30 | 6.851525e-08 | 2 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 65 | 7.109258e-08 | 2 |
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] | 21 | 1.246370e-07 | 2 |
| GO:BP | GO:0046390 | ribose phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 14 | 1.767451e-07 | 2 |
| GO:BP | GO:1901293 | nucleoside phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie] | 17 | 3.807832e-07 | 2 |
| GO:BP | GO:0009259 | ribonucleotide metabolic process | "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 18 | 6.716282e-07 | 2 |
| GO:BP | GO:0009150 | purine ribonucleotide metabolic process | "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 17 | 2.096102e-06 | 2 |
| GO:BP | GO:0090407 | organophosphate biosynthetic process | "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg] | 22 | 2.333543e-06 | 2 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 45 | 5.609796e-06 | 2 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 45 | 5.833430e-06 | 2 |
| GO:BP | GO:0006734 | NADH metabolic process | "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] | 7 | 8.860427e-06 | 2 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 12 | 9.404768e-06 | 2 |
| GO:BP | GO:0015980 | energy derivation by oxidation of organic compounds | "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] | 16 | 1.226101e-05 | 2 |
| GO:BP | GO:0009260 | ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 12 | 1.487601e-05 | 2 |
| GO:BP | GO:0019752 | carboxylic acid metabolic process | "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] | 25 | 1.774805e-05 | 2 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 67 | 2.061843e-05 | 2 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 33 | 2.149372e-05 | 2 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 32 | 2.519984e-05 | 2 |
| GO:BP | GO:0043436 | oxoacid metabolic process | "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] | 25 | 2.877852e-05 | 2 |
| GO:BP | GO:0009165 | nucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] | 13 | 3.167757e-05 | 2 |
| GO:BP | GO:0006082 | organic acid metabolic process | "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] | 25 | 3.274644e-05 | 2 |
| GO:BP | GO:0009141 | nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 14 | 3.660527e-05 | 2 |
| GO:BP | GO:0009152 | purine ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 11 | 6.205376e-05 | 2 |
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 11 | 6.615054e-05 | 2 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 11 | 6.615054e-05 | 2 |
| GO:BP | GO:0005975 | carbohydrate metabolic process | "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] | 19 | 7.306045e-05 | 2 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 38 | 7.532420e-05 | 2 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 38 | 7.942842e-05 | 2 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 124 | 9.575181e-05 | 2 |
| GO:BP | GO:0009199 | ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 13 | 1.411582e-04 | 2 |
| GO:BP | GO:0009144 | purine nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 13 | 1.411582e-04 | 2 |
| GO:BP | GO:1901137 | carbohydrate derivative biosynthetic process | "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie] | 19 | 1.785628e-04 | 2 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 13 | 2.187697e-04 | 2 |
| GO:BP | GO:0007005 | mitochondrion organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] | 16 | 3.033158e-04 | 2 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 45 | 3.906197e-04 | 2 |
| GO:BP | GO:0006164 | purine nucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 11 | 3.942058e-04 | 2 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 45 | 4.426287e-04 | 2 |
| GO:BP | GO:0015031 | protein transport | "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 30 | 4.763635e-04 | 2 |
| GO:BP | GO:0006520 | amino acid metabolic process | "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732] | 13 | 6.528946e-04 | 2 |
| GO:BP | GO:0009205 | purine ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 12 | 7.970593e-04 | 2 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 98 | 9.246478e-04 | 2 |
| GO:BP | GO:0072522 | purine-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 12 | 9.417953e-04 | 2 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 35 | 9.616441e-04 | 2 |
| GO:BP | GO:0071705 | nitrogen compound transport | "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] | 35 | 9.616441e-04 | 2 |
| GO:BP | GO:0016236 | macroautophagy | "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339] | 14 | 1.020688e-03 | 2 |
| GO:BP | GO:0006886 | intracellular protein transport | "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] | 19 | 1.595546e-03 | 2 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 48 | 1.873317e-03 | 2 |
| GO:BP | GO:0019318 | hexose metabolic process | "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] | 11 | 1.892471e-03 | 2 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 28 | 2.064882e-03 | 2 |
| GO:BP | GO:0046034 | ATP metabolic process | "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] | 11 | 2.153489e-03 | 2 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 52 | 2.243027e-03 | 2 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 84 | 2.812132e-03 | 2 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 29 | 3.631833e-03 | 2 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 13 | 3.726203e-03 | 2 |
| GO:BP | GO:0005996 | monosaccharide metabolic process | "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732] | 11 | 5.048226e-03 | 2 |
| GO:BP | GO:0001666 | response to hypoxia | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] | 12 | 5.093715e-03 | 2 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 131 | 5.911544e-03 | 2 |
| GO:BP | GO:2001245 | regulation of phosphatidylcholine biosynthetic process | "Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol] | 3 | 6.965232e-03 | 2 |
| GO:BP | GO:0048193 | Golgi vesicle transport | "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] | 12 | 7.115010e-03 | 2 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 21 | 7.223845e-03 | 2 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 17 | 7.259206e-03 | 2 |
| GO:BP | GO:0036293 | response to decreased oxygen levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] | 12 | 8.103219e-03 | 2 |
| GO:BP | GO:0019674 | NAD metabolic process | "The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions." [PMID:28648096] | 5 | 8.770637e-03 | 2 |
| GO:BP | GO:0009142 | nucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 8.807982e-03 | 2 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 12 | 8.921754e-03 | 2 |
| GO:BP | GO:0045184 | establishment of protein localization | "The directed movement of a protein to a specific location." [GOC:bf] | 33 | 9.176225e-03 | 2 |
| GO:BP | GO:0046364 | monosaccharide biosynthetic process | "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] | 7 | 9.339604e-03 | 2 |
| GO:BP | GO:0070585 | protein localization to mitochondrion | "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd] | 8 | 1.172615e-02 | 2 |
| GO:BP | GO:0170033 | L-amino acid metabolic process | "The chemical reactions and pathways involving an L-amino acid." [GOC:edw] | 9 | 1.184492e-02 | 2 |
| GO:BP | GO:0043490 | malate-aspartate shuttle | "The process of transferring reducing equivalents from NADH in the cytosol to the mitochondria via malate. Cytosolic aspartate aminotransferase converts aspartate to oxaloacetate, and cytosolic malate dehydrogenase uses NADH to convert oxaloacetate to malate in the cytosol; the malate-alpha-ketoglutarate carrier then transports the malate into the mitochondria where mitochondrial malate dehydrogenase uses NAD to convert malate back to oxaloacetate; the electrons on the reduced NADH are then available for use in the electron transport chain; mitochondrial aspartate aminotransferase converts oxaloacetate to aspartate, and the glutamate-aspartate carrier transports the aspartate back to the cytosol to complete the cycle." [GOC:sjm, PMID:16368075] | 3 | 1.385398e-02 | 2 |
| GO:BP | GO:0010042 | response to manganese ion | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:sm] | 4 | 1.454823e-02 | 2 |
| GO:BP | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] | 8 | 1.461396e-02 | 2 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 49 | 1.692347e-02 | 2 |
| GO:BP | GO:0006006 | glucose metabolic process | "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] | 9 | 1.775539e-02 | 2 |
| GO:BP | GO:0006914 | autophagy | "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464] | 16 | 1.840868e-02 | 2 |
| GO:BP | GO:0061919 | process utilizing autophagic mechanism | "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] | 16 | 1.840868e-02 | 2 |
| GO:BP | GO:0070482 | response to oxygen levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] | 12 | 1.909779e-02 | 2 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 33 | 1.996670e-02 | 2 |
| GO:BP | GO:0008637 | apoptotic mitochondrial changes | "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis] | 7 | 2.121622e-02 | 2 |
| GO:BP | GO:0045333 | cellular respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] | 10 | 2.493198e-02 | 2 |
| GO:BP | GO:0016051 | carbohydrate biosynthetic process | "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 9 | 2.496627e-02 | 2 |
| GO:BP | GO:0009167 | purine ribonucleoside monophosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 5 | 2.555296e-02 | 2 |
| GO:BP | GO:0009126 | purine nucleoside monophosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 5 | 3.223231e-02 | 2 |
| GO:BP | GO:0006284 | base-excision repair | "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] | 5 | 4.019729e-02 | 2 |
| GO:BP | GO:0010821 | regulation of mitochondrion organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] | 7 | 4.353976e-02 | 2 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 22 | 4.384335e-02 | 2 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 21 | 4.822292e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 105 | 6.638597e-13 | 2 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 90 | 1.270857e-06 | 2 |
| GO:MF | GO:0016874 | ligase activity | "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-] | 13 | 1.449589e-06 | 2 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 85 | 2.485605e-05 | 2 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 35 | 7.132453e-05 | 2 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 44 | 7.996426e-05 | 2 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 42 | 8.738831e-05 | 2 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 44 | 9.913278e-05 | 2 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 148 | 1.170407e-04 | 2 |
| GO:MF | GO:0016491 | oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-] | 22 | 1.544063e-04 | 2 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 45 | 1.688044e-04 | 2 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 46 | 2.554993e-04 | 2 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 163 | 2.932150e-04 | 2 |
| GO:MF | GO:0016787 | hydrolase activity | "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] | 52 | 2.976271e-04 | 2 |
| GO:MF | GO:0004177 | aminopeptidase activity | "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain." [EC:3.4.11.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837] | 6 | 5.002152e-04 | 2 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 38 | 8.572214e-04 | 2 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 31 | 9.695350e-04 | 2 |
| GO:MF | GO:0070006 | metalloaminopeptidase activity | "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE] | 5 | 1.141179e-03 | 2 |
| GO:MF | GO:0005536 | D-glucose binding | "Binding to D-enantiomers of glucose." [GOC:jl] | 4 | 1.466215e-03 | 2 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 38 | 1.707970e-03 | 2 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 31 | 1.718770e-03 | 2 |
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 7 | 2.032818e-03 | 2 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 38 | 2.064485e-03 | 2 |
| GO:MF | GO:0048029 | monosaccharide binding | "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid] | 7 | 2.221090e-03 | 2 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 13 | 2.583865e-03 | 2 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 37 | 6.478928e-03 | 2 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 36 | 7.493353e-03 | 2 |
| GO:MF | GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] | 8 | 1.008715e-02 | 2 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 16 | 1.039406e-02 | 2 |
| GO:MF | GO:0008235 | metalloexopeptidase activity | "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml] | 6 | 1.164388e-02 | 2 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 40 | 1.428233e-02 | 2 |
| GO:MF | GO:0016879 | ligase activity, forming carbon-nitrogen bonds | "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3.-.-] | 5 | 3.868819e-02 | 2 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 7 | 4.571595e-02 | 2 |
| GO:MF | GO:0140431 | DNA-(abasic site) binding | "Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base." [PMID:23245849] | 2 | 4.955669e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 110 | 4.209217e-10 | 2 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 87 | 4.938593e-09 | 2 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 49 | 5.330455e-09 | 2 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 113 | 9.490521e-09 | 2 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 43 | 9.534193e-09 | 2 |
| HPA | HPA:0300000 | Lung | Lung | 120 | 1.852936e-08 | 2 |
| HPA | HPA:0630000 | Cervix | Cervix | 116 | 2.292183e-08 | 2 |
| HPA | HPA:0380000 | Placenta | Placenta | 121 | 2.414507e-08 | 2 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 111 | 9.720774e-08 | 2 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 111 | 9.720774e-08 | 2 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 114 | 1.109175e-07 | 2 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 114 | 1.109175e-07 | 2 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 122 | 1.683503e-07 | 2 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 106 | 2.290909e-07 | 2 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 113 | 2.389511e-07 | 2 |
| HPA | HPA:0030000 | Appendix | Appendix | 122 | 2.912137e-07 | 2 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 116 | 2.951282e-07 | 2 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 116 | 2.951282e-07 | 2 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 119 | 2.958798e-07 | 2 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 114 | 3.466992e-07 | 2 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 105 | 4.153878e-07 | 2 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 112 | 4.408365e-07 | 2 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 118 | 6.177931e-07 | 2 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 111 | 6.289370e-07 | 2 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 118 | 6.733121e-07 | 2 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 96 | 7.881188e-07 | 2 |
| HPA | HPA:0290000 | Liver | Liver | 107 | 1.158012e-06 | 2 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 112 | 1.377094e-06 | 2 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 105 | 1.580681e-06 | 2 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 111 | 4.314912e-06 | 2 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 109 | 4.629477e-06 | 2 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 113 | 4.946542e-06 | 2 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 33 | 5.275728e-06 | 2 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 92 | 6.303261e-06 | 2 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 118 | 6.405175e-06 | 2 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 118 | 6.405175e-06 | 2 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 113 | 6.451551e-06 | 2 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 99 | 7.332081e-06 | 2 |
| HPA | HPA:0270000 | Kidney | Kidney | 123 | 8.344667e-06 | 2 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 109 | 9.741435e-06 | 2 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 109 | 9.741435e-06 | 2 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 118 | 1.157364e-05 | 2 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 118 | 1.157364e-05 | 2 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 118 | 1.211907e-05 | 2 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 118 | 1.211907e-05 | 2 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 29 | 1.502721e-05 | 2 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 89 | 1.789325e-05 | 2 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 101 | 1.806392e-05 | 2 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 104 | 2.152213e-05 | 2 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 104 | 2.152213e-05 | 2 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 94 | 2.213640e-05 | 2 |
| HPA | HPA:0050000 | Breast | Breast | 113 | 2.706790e-05 | 2 |
| HPA | HPA:0530000 | Spleen | Spleen | 100 | 2.715459e-05 | 2 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 108 | 2.847805e-05 | 2 |
| HPA | HPA:0390000 | Prostate | Prostate | 108 | 2.847805e-05 | 2 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 115 | 2.919842e-05 | 2 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 114 | 3.012002e-05 | 2 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 114 | 3.012002e-05 | 2 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 64 | 3.323170e-05 | 2 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 89 | 3.352927e-05 | 2 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 30 | 3.728114e-05 | 2 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 98 | 3.785786e-05 | 2 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 68 | 4.311190e-05 | 2 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 114 | 4.477148e-05 | 2 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 114 | 4.477148e-05 | 2 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 87 | 4.841377e-05 | 2 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 113 | 5.115508e-05 | 2 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 110 | 5.808152e-05 | 2 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 25 | 6.665014e-05 | 2 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 26 | 9.542648e-05 | 2 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 33 | 1.051735e-04 | 2 |
| HPA | HPA:0400000 | Rectum | Rectum | 119 | 1.085271e-04 | 2 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 89 | 1.152050e-04 | 2 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 114 | 1.301905e-04 | 2 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 24 | 1.331506e-04 | 2 |
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 85 | 1.364282e-04 | 2 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 27 | 1.424607e-04 | 2 |
| HPA | HPA:0340000 | Ovary | Ovary | 93 | 1.615977e-04 | 2 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 102 | 2.122673e-04 | 2 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 90 | 2.229693e-04 | 2 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 31 | 2.398495e-04 | 2 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 24 | 2.448254e-04 | 2 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 75 | 2.664045e-04 | 2 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 79 | 4.011467e-04 | 2 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 85 | 4.193973e-04 | 2 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 119 | 4.428243e-04 | 2 |
| HPA | HPA:0130000 | Colon | Colon | 121 | 4.494543e-04 | 2 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 117 | 5.484254e-04 | 2 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 38 | 6.112120e-04 | 2 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 26 | 6.192892e-04 | 2 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 57 | 6.228048e-04 | 2 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 88 | 7.685026e-04 | 2 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 94 | 8.555343e-04 | 2 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 24 | 9.736282e-04 | 2 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 99 | 1.041368e-03 | 2 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 101 | 1.058171e-03 | 2 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 74 | 1.063500e-03 | 2 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 106 | 1.064406e-03 | 2 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 87 | 1.098210e-03 | 2 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 91 | 1.142505e-03 | 2 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 27 | 1.191469e-03 | 2 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 27 | 1.381573e-03 | 2 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 33 | 1.528966e-03 | 2 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 26 | 1.583609e-03 | 2 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 99 | 1.877555e-03 | 2 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 18 | 2.072903e-03 | 2 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 22 | 2.091397e-03 | 2 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 22 | 2.363501e-03 | 2 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 92 | 2.457922e-03 | 2 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 95 | 2.552218e-03 | 2 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 95 | 2.552218e-03 | 2 |
| HPA | HPA:0620000 | Vagina | Vagina | 96 | 2.991134e-03 | 2 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 96 | 2.991134e-03 | 2 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 23 | 3.005363e-03 | 2 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 74 | 3.180016e-03 | 2 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 72 | 3.229817e-03 | 2 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 80 | 3.262980e-03 | 2 |
| HPA | HPA:0570731 | Testis; Leydig cells[≥Low] | Testis; Leydig cells[≥Low] | 108 | 3.373482e-03 | 2 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 42 | 3.683154e-03 | 2 |
| HPA | HPA:0570000 | Testis | Testis | 125 | 3.688849e-03 | 2 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 115 | 3.779806e-03 | 2 |
| HPA | HPA:0080000 | Caudate | Caudate | 106 | 3.829489e-03 | 2 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 26 | 3.936397e-03 | 2 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 39 | 4.024321e-03 | 2 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 25 | 4.119894e-03 | 2 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 75 | 4.488857e-03 | 2 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 105 | 5.150520e-03 | 2 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 105 | 5.150520e-03 | 2 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 108 | 5.241088e-03 | 2 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 108 | 5.484611e-03 | 2 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 21 | 5.503808e-03 | 2 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 74 | 5.524049e-03 | 2 |
| HPA | HPA:0151292 | Duodenum; endocrine cells[≥Medium] | Duodenum; endocrine cells[≥Medium] | 17 | 6.477417e-03 | 2 |
| HPA | HPA:0090181 | Cerebellum; cells in granular layer[≥Low] | Cerebellum; cells in granular layer[≥Low] | 78 | 6.616595e-03 | 2 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 22 | 7.003317e-03 | 2 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 92 | 7.308145e-03 | 2 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 23 | 7.523984e-03 | 2 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 90 | 7.634157e-03 | 2 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 56 | 7.927595e-03 | 2 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 44 | 8.270036e-03 | 2 |
| HPA | HPA:0151342 | Duodenum; glands of Brunner[≥Medium] | Duodenum; glands of Brunner[≥Medium] | 11 | 8.359866e-03 | 2 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 25 | 8.752889e-03 | 2 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 89 | 8.769165e-03 | 2 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 82 | 9.241456e-03 | 2 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 90 | 9.592644e-03 | 2 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 82 | 1.046701e-02 | 2 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 35 | 1.058335e-02 | 2 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 70 | 1.149153e-02 | 2 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 87 | 1.254837e-02 | 2 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 16 | 1.330056e-02 | 2 |
| HPA | HPA:0381191 | Placenta; cytotrophoblasts[≥Low] | Placenta; cytotrophoblasts[≥Low] | 17 | 1.391705e-02 | 2 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 90 | 1.621072e-02 | 2 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 16 | 1.950807e-02 | 2 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 19 | 2.081526e-02 | 2 |
| HPA | HPA:0151291 | Duodenum; endocrine cells[≥Low] | Duodenum; endocrine cells[≥Low] | 17 | 2.095105e-02 | 2 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 78 | 2.148905e-02 | 2 |
| HPA | HPA:0390053 | Prostate; glandular cells[High] | Prostate; glandular cells[High] | 32 | 2.149454e-02 | 2 |
| HPA | HPA:0151341 | Duodenum; glands of Brunner[≥Low] | Duodenum; glands of Brunner[≥Low] | 12 | 2.177224e-02 | 2 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 50 | 2.230666e-02 | 2 |
| HPA | HPA:0271111 | Kidney; bowman's capsule[≥Low] | Kidney; bowman's capsule[≥Low] | 12 | 2.422966e-02 | 2 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 15 | 2.569960e-02 | 2 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 75 | 2.643209e-02 | 2 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 17 | 2.951121e-02 | 2 |
| HPA | HPA:0481292 | Small intestine; endocrine cells[≥Medium] | Small intestine; endocrine cells[≥Medium] | 16 | 3.115008e-02 | 2 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 80 | 3.339020e-02 | 2 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 66 | 3.506696e-02 | 2 |
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 41 | 3.709412e-02 | 2 |
| HPA | HPA:0060103 | Bronchus; respiratory epithelial cells[High] | Bronchus; respiratory epithelial cells[High] | 39 | 3.883720e-02 | 2 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 18 | 4.365361e-02 | 2 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 20 | 4.554392e-02 | 2 |
| HPA | HPA:0381202 | Placenta; hofbauer cells[≥Medium] | Placenta; hofbauer cells[≥Medium] | 14 | 4.946528e-02 | 2 |
| HPA | HPA:0150893 | Duodenum; goblet cells[High] | Duodenum; goblet cells[High] | 10 | 4.996365e-02 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 144 | 0.000002 | 2 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 154 | 0.000002 | 2 |
| TF | TF:M08205 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | 151 | 0.000003 | 2 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 153 | 0.000004 | 2 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 147 | 0.000015 | 2 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 156 | 0.000022 | 2 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 122 | 0.000045 | 2 |
| TF | TF:M12173 | Factor: GKLF; motif: NNCCMCRCCCN | Factor: GKLF; motif: NNCCMCRCCCN | 118 | 0.000081 | 2 |
| TF | TF:M00736 | Factor: E2F-1:DP-1; motif: TTTCSCGC | Factor: E2F-1:DP-1; motif: TTTCSCGC | 120 | 0.000158 | 2 |
| TF | TF:M08313_1 | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 | 114 | 0.000233 | 2 |
| TF | TF:M09892 | Factor: E2F-1; motif: NNNNGGCGGGAARN | Factor: E2F-1; motif: NNNNGGCGGGAARN | 142 | 0.000269 | 2 |
| TF | TF:M09894 | Factor: E2F-4; motif: SNGGGCGGGAANN | Factor: E2F-4; motif: SNGGGCGGGAANN | 157 | 0.000292 | 2 |
| TF | TF:M02090 | Factor: E2F-4; motif: GCGGGAAANA | Factor: E2F-4; motif: GCGGGAAANA | 131 | 0.000349 | 2 |
| TF | TF:M11531 | Factor: E2F-2; motif: GCGCGCGCGYW | Factor: E2F-2; motif: GCGCGCGCGYW | 140 | 0.000376 | 2 |
| TF | TF:M07206_1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | 123 | 0.000384 | 2 |
| TF | TF:M02065_1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | 91 | 0.000384 | 2 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 68 | 0.000921 | 2 |
| TF | TF:M01783 | Factor: SP2; motif: GGGCGGGAC | Factor: SP2; motif: GGGCGGGAC | 108 | 0.001225 | 2 |
| TF | TF:M00333 | Factor: ZF5; motif: NRNGNGCGCGCWN | Factor: ZF5; motif: NRNGNGCGCGCWN | 150 | 0.001229 | 2 |
| TF | TF:M07206 | Factor: E2F-1; motif: NGGGCGGGARV | Factor: E2F-1; motif: NGGGCGGGARV | 147 | 0.001340 | 2 |
| TF | TF:M11434 | Factor: Elk-1; motif: NRSCGGAAGNN | Factor: Elk-1; motif: NRSCGGAAGNN | 100 | 0.001467 | 2 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 156 | 0.001482 | 2 |
| TF | TF:M08525 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM | 160 | 0.001486 | 2 |
| TF | TF:M12151 | Factor: Sp1; motif: NWRGCCMCGCCCMCN | Factor: Sp1; motif: NWRGCCMCGCCCMCN | 88 | 0.001629 | 2 |
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 144 | 0.001652 | 2 |
| TF | TF:M00428 | Factor: E2F-1; motif: NKTSSCGC | Factor: E2F-1; motif: NKTSSCGC | 106 | 0.001884 | 2 |
| TF | TF:M12600 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | 103 | 0.002254 | 2 |
| TF | TF:M08913_1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | 50 | 0.002428 | 2 |
| TF | TF:M11529_1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | 146 | 0.002539 | 2 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 150 | 0.003323 | 2 |
| TF | TF:M01660 | Factor: GABP-alpha; motif: CTTCCK | Factor: GABP-alpha; motif: CTTCCK | 121 | 0.006140 | 2 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 158 | 0.006488 | 2 |
| TF | TF:M12597 | Factor: E2F1; motif: GSGCGGGAAN | Factor: E2F1; motif: GSGCGGGAAN | 142 | 0.006921 | 2 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 116 | 0.008228 | 2 |
| TF | TF:M11396_1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | 68 | 0.008463 | 2 |
| TF | TF:M09892_1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | 106 | 0.008797 | 2 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 154 | 0.009697 | 2 |
| TF | TF:M11529 | Factor: E2F-2; motif: GCGCGCGCNCS | Factor: E2F-2; motif: GCGCGCGCNCS | 155 | 0.010063 | 2 |
| TF | TF:M04823 | Factor: E2F-4; motif: NNTTCCCGCCNN | Factor: E2F-4; motif: NNTTCCCGCCNN | 133 | 0.010159 | 2 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 125 | 0.010408 | 2 |
| TF | TF:M08759 | Factor: c-Ets-2; motif: NCCGGAAGTG | Factor: c-Ets-2; motif: NCCGGAAGTG | 98 | 0.010641 | 2 |
| TF | TF:M11535 | Factor: E2F-4; motif: TTTTGGCGCCAWWN | Factor: E2F-4; motif: TTTTGGCGCCAWWN | 119 | 0.010827 | 2 |
| TF | TF:M02071_1 | Factor: ETV7; motif: NCCGGAANNN; match class: 1 | Factor: ETV7; motif: NCCGGAANNN; match class: 1 | 63 | 0.011608 | 2 |
| TF | TF:M11530 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | 145 | 0.012008 | 2 |
| TF | TF:M03567 | Factor: Sp2; motif: NYSGCCCCGCCCCCY | Factor: Sp2; motif: NYSGCCCCGCCCCCY | 93 | 0.013769 | 2 |
| TF | TF:M00196 | Factor: Sp1; motif: NGGGGGCGGGGYN | Factor: Sp1; motif: NGGGGGCGGGGYN | 114 | 0.014362 | 2 |
| TF | TF:M03971 | Factor: ELK1; motif: NACTTCCGSCGGAAGYN | Factor: ELK1; motif: NACTTCCGSCGGAAGYN | 121 | 0.018359 | 2 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 134 | 0.018617 | 2 |
| TF | TF:M11396 | Factor: Erg; motif: NACCGGAARTN | Factor: Erg; motif: NACCGGAARTN | 117 | 0.020214 | 2 |
| TF | TF:M12186 | Factor: BTEB4; motif: NCCACGCCCM | Factor: BTEB4; motif: NCCACGCCCM | 104 | 0.022363 | 2 |
| TF | TF:M10071 | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG | 99 | 0.025031 | 2 |
| TF | TF:M11531_1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | 129 | 0.025375 | 2 |
| TF | TF:M09606 | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | 79 | 0.027954 | 2 |
| TF | TF:M00431 | Factor: E2F-1; motif: TTTSGCGS | Factor: E2F-1; motif: TTTSGCGS | 88 | 0.029160 | 2 |
| TF | TF:M03807 | Factor: SP2; motif: GNNGGGGGCGGGGSN | Factor: SP2; motif: GNNGGGGGCGGGGSN | 98 | 0.031809 | 2 |
| TF | TF:M12666 | Factor: SP1; motif: GGCCCCGCCCCCN | Factor: SP1; motif: GGCCCCGCCCCCN | 100 | 0.032542 | 2 |
| TF | TF:M02090_1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | 80 | 0.033542 | 2 |
| TF | TF:M00025_1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | 61 | 0.036196 | 2 |
| TF | TF:M07380_1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | 94 | 0.037918 | 2 |
| TF | TF:M11424 | Factor: Erm; motif: NNSCGGAWGYN | Factor: Erm; motif: NNSCGGAWGYN | 95 | 0.038053 | 2 |
| TF | TF:M04714 | Factor: Elf-1; motif: ACTTCCGGG | Factor: Elf-1; motif: ACTTCCGGG | 92 | 0.038212 | 2 |
| TF | TF:M08525_1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | 148 | 0.043256 | 2 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 111 | 0.043416 | 2 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 131 | 0.043882 | 2 |
| TF | TF:M07415 | Factor: Elf-1; motif: AWCCCGGAAGTN | Factor: Elf-1; motif: AWCCCGGAAGTN | 93 | 0.045367 | 2 |
| TF | TF:M03971_1 | Factor: ELK1; motif: NACTTCCGSCGGAAGYN; match class: 1 | Factor: ELK1; motif: NACTTCCGSCGGAAGYN; match class: 1 | 86 | 0.046682 | 2 |
| TF | TF:M11882 | Factor: pax-6; motif: NYACGCNYSANYGMNCN | Factor: pax-6; motif: NYACGCNYSANYGMNCN | 149 | 0.047412 | 2 |
| TF | TF:M07084 | Factor: E2F-4; motif: NGGCGGGAARN | Factor: E2F-4; motif: NGGCGGGAARN | 117 | 0.047482 | 2 |
| TF | TF:M13135 | Factor: SP4; motif: GGCCCCGCCCCCN | Factor: SP4; motif: GGCCCCGCCCCCN | 72 | 0.049228 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 13 | 0.000004 | 2 |
| KEGG | KEGG:01100 | Metabolic pathways | Metabolic pathways | 32 | 0.025482 | 2 |
| KEGG | KEGG:01200 | Carbon metabolism | Carbon metabolism | 7 | 0.028711 | 2 |
| KEGG | KEGG:03460 | Fanconi anemia pathway | Fanconi anemia pathway | 5 | 0.031205 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-let-7b-5p | hsa-let-7b-5p | hsa-let-7b-5p | 33 | 0.000005 | 2 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 30 | 0.002789 | 2 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 24 | 0.005233 | 2 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 22 | 0.005242 | 2 |
| MIRNA | MIRNA:hsa-mir-30a-5p | hsa-mir-30a-5p | hsa-mir-30a-5p | 20 | 0.006808 | 2 |
| MIRNA | MIRNA:hsa-mir-210-3p | hsa-mir-210-3p | hsa-mir-210-3p | 8 | 0.016136 | 2 |
| MIRNA | MIRNA:hsa-mir-34a-5p | hsa-mir-34a-5p | hsa-mir-34a-5p | 17 | 0.017789 | 2 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 30 | 0.033821 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5394 | UDP derived sugars synthesis in fibroblasts | UDP derived sugars synthesis in fibroblasts | 4 | 0.000833 | 2 |
| WP | WP:WP4595 | Urea cycle and associated pathways | Urea cycle and associated pathways | 5 | 0.001045 | 2 |
| WP | WP:WP5355 | Metabolic epileptic disorders | Metabolic epileptic disorders | 8 | 0.001378 | 2 |
| WP | WP:WP534 | Glycolysis and gluconeogenesis | Glycolysis and gluconeogenesis | 6 | 0.001787 | 2 |
| WP | WP:WP4290 | Metabolic reprogramming in colon cancer | Metabolic reprogramming in colon cancer | 5 | 0.017796 | 2 |
| WP | WP:WP5049 | Glycolysis in senescence | Glycolysis in senescence | 3 | 0.037789 | 2 |
| WP | WP:WP3875 | ATR signaling | ATR signaling | 3 | 0.037789 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 6 | 0.001334 | 2 |
| REAC | REAC:R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | PCNA-Dependent Long Patch Base Excision Repair | 5 | 0.001640 | 2 |
| REAC | REAC:R-HSA-3371511 | HSF1 activation | HSF1 activation | 4 | 0.003688 | 2 |
| REAC | REAC:R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 5 | 0.004120 | 2 |
| REAC | REAC:R-HSA-901042 | Calnexin/calreticulin cycle | Calnexin/calreticulin cycle | 5 | 0.005052 | 2 |
| REAC | REAC:R-HSA-15869 | Metabolism of nucleotides | Metabolism of nucleotides | 8 | 0.005315 | 2 |
| REAC | REAC:R-HSA-69166 | Removal of the Flap Intermediate | Removal of the Flap Intermediate | 4 | 0.007318 | 2 |
| REAC | REAC:R-HSA-69183 | Processive synthesis on the lagging strand | Processive synthesis on the lagging strand | 4 | 0.009886 | 2 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 45 | 0.014490 | 2 |
| REAC | REAC:R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | Removal of the Flap Intermediate from the C-strand | 4 | 0.016916 | 2 |
| REAC | REAC:R-HSA-73933 | Resolution of Abasic Sites (AP sites) | Resolution of Abasic Sites (AP sites) | 5 | 0.026277 | 2 |
| REAC | REAC:R-HSA-110320 | Translesion Synthesis by POLH | Translesion Synthesis by POLH | 4 | 0.027037 | 2 |
| REAC | REAC:R-HSA-174414 | Processive synthesis on the C-strand of the telomere | Processive synthesis on the C-strand of the telomere | 4 | 0.027037 | 2 |
| REAC | REAC:R-HSA-446203 | Asparagine N-linked glycosylation | Asparagine N-linked glycosylation | 13 | 0.031428 | 2 |
| REAC | REAC:R-HSA-69186 | Lagging Strand Synthesis | Lagging Strand Synthesis | 4 | 0.033481 | 2 |
| REAC | REAC:R-HSA-6783310 | Fanconi Anemia Pathway | Fanconi Anemia Pathway | 5 | 0.038983 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5229 | RPA complex | RPA complex | 2 | 0.049771 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 42 | 1.260554e-50 | 3 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 58 | 1.913893e-41 | 3 |
| GO:BP | GO:0042254 | ribosome biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] | 27 | 9.898350e-18 | 3 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 123 | 7.722337e-17 | 3 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 123 | 6.275410e-15 | 3 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 83 | 3.039169e-14 | 3 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 136 | 6.106102e-14 | 3 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 42 | 2.637441e-12 | 3 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 135 | 4.727796e-12 | 3 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 21 | 2.322926e-11 | 3 |
| GO:BP | GO:1903312 | negative regulation of mRNA metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 14 | 3.995692e-11 | 3 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 42 | 5.495122e-11 | 3 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 123 | 9.211123e-11 | 3 |
| GO:BP | GO:0006364 | rRNA processing | "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] | 18 | 1.039904e-10 | 3 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 22 | 1.147169e-10 | 3 |
| GO:BP | GO:2000767 | positive regulation of cytoplasmic translation | "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 8 | 1.407100e-10 | 3 |
| GO:BP | GO:0016072 | rRNA metabolic process | "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] | 19 | 1.568874e-10 | 3 |
| GO:BP | GO:0045727 | positive regulation of translation | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] | 15 | 1.570004e-10 | 3 |
| GO:BP | GO:0070934 | CRD-mediated mRNA stabilization | "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] | 7 | 5.289437e-10 | 3 |
| GO:BP | GO:0042274 | ribosomal small subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 13 | 1.201195e-09 | 3 |
| GO:BP | GO:1902369 | negative regulation of RNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] | 12 | 4.939877e-09 | 3 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 58 | 7.022580e-09 | 3 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 79 | 1.254016e-08 | 3 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 53 | 1.413047e-08 | 3 |
| GO:BP | GO:0043489 | RNA stabilization | "Prevention of degradation of RNA molecules." [GOC:go_curators] | 11 | 1.929644e-08 | 3 |
| GO:BP | GO:1902373 | negative regulation of mRNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865] | 11 | 2.227810e-08 | 3 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 139 | 2.646229e-08 | 3 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 59 | 3.365507e-08 | 3 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 53 | 3.627115e-08 | 3 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 94 | 1.128739e-07 | 3 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 64 | 1.270120e-07 | 3 |
| GO:BP | GO:0048255 | mRNA stabilization | "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid] | 10 | 1.295030e-07 | 3 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 61 | 1.308660e-07 | 3 |
| GO:BP | GO:0006402 | mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 16 | 1.550480e-07 | 3 |
| GO:BP | GO:1900152 | negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] | 6 | 2.078885e-07 | 3 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 49 | 2.615137e-07 | 3 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 28 | 3.396429e-07 | 3 |
| GO:BP | GO:1900151 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] | 7 | 3.650624e-07 | 3 |
| GO:BP | GO:2000765 | regulation of cytoplasmic translation | "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 8 | 3.706572e-07 | 3 |
| GO:BP | GO:0061013 | regulation of mRNA catabolic process | "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 14 | 3.761618e-07 | 3 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 40 | 4.909684e-07 | 3 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 49 | 1.013690e-06 | 3 |
| GO:BP | GO:0141188 | nucleic acid catabolic process | "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators] | 17 | 1.055361e-06 | 3 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 32 | 1.253673e-06 | 3 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 55 | 1.263300e-06 | 3 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 39 | 1.328641e-06 | 3 |
| GO:BP | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc] | 9 | 1.349552e-06 | 3 |
| GO:BP | GO:0042255 | ribosome assembly | "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428] | 9 | 1.349552e-06 | 3 |
| GO:BP | GO:0043488 | regulation of mRNA stability | "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] | 13 | 1.401857e-06 | 3 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 87 | 1.561331e-06 | 3 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 32 | 1.704625e-06 | 3 |
| GO:BP | GO:0006401 | RNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 16 | 2.434699e-06 | 3 |
| GO:BP | GO:0043487 | regulation of RNA stability | "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] | 13 | 3.080929e-06 | 3 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 95 | 3.433181e-06 | 3 |
| GO:BP | GO:0000956 | nuclear-transcribed mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] | 11 | 4.061047e-06 | 3 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 57 | 4.176858e-06 | 3 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 18 | 4.727149e-06 | 3 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 40 | 7.427456e-06 | 3 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 82 | 1.002241e-05 | 3 |
| GO:BP | GO:1903313 | positive regulation of mRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 11 | 1.534726e-05 | 3 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 45 | 2.358633e-05 | 3 |
| GO:BP | GO:0016071 | mRNA metabolic process | "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 40 | 3.033748e-05 | 3 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 46 | 3.685324e-05 | 3 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 85 | 3.735789e-05 | 3 |
| GO:BP | GO:0061157 | mRNA destabilization | "Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh] | 9 | 1.024766e-04 | 3 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 15 | 1.174619e-04 | 3 |
| GO:BP | GO:0050779 | RNA destabilization | "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai] | 9 | 1.433177e-04 | 3 |
| GO:BP | GO:1901796 | regulation of signal transduction by p53 class mediator | "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 9 | 1.433177e-04 | 3 |
| GO:BP | GO:0061014 | positive regulation of mRNA catabolic process | "Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 9 | 1.555101e-04 | 3 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 71 | 1.579777e-04 | 3 |
| GO:BP | GO:0022613 | ribonucleoprotein complex biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] | 35 | 2.215516e-04 | 3 |
| GO:BP | GO:0034063 | stress granule assembly | "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519] | 6 | 2.649085e-04 | 3 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 33 | 2.970108e-04 | 3 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 33 | 3.052120e-04 | 3 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 27 | 3.458129e-04 | 3 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 71 | 3.572432e-04 | 3 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 52 | 4.127026e-04 | 3 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 73 | 4.750285e-04 | 3 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 72 | 5.033296e-04 | 3 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 79 | 5.572285e-04 | 3 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 17 | 7.059845e-04 | 3 |
| GO:BP | GO:0010629 | negative regulation of gene expression | "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 32 | 7.544730e-04 | 3 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 50 | 7.675952e-04 | 3 |
| GO:BP | GO:0006325 | chromatin organization | "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] | 22 | 8.615042e-04 | 3 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 50 | 9.111702e-04 | 3 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 75 | 9.805221e-04 | 3 |
| GO:BP | GO:0050684 | regulation of mRNA processing | "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] | 9 | 1.069866e-03 | 3 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 79 | 1.174378e-03 | 3 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 10 | 1.246253e-03 | 3 |
| GO:BP | GO:0000027 | ribosomal large subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428] | 5 | 1.250254e-03 | 3 |
| GO:BP | GO:0042273 | ribosomal large subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 7 | 1.338604e-03 | 3 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 23 | 1.966158e-03 | 3 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] | 24 | 2.142322e-03 | 3 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 28 | 2.217436e-03 | 3 |
| GO:BP | GO:0006396 | RNA processing | "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] | 48 | 2.259715e-03 | 3 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 26 | 2.397182e-03 | 3 |
| GO:BP | GO:0006338 | chromatin remodeling | "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] | 19 | 2.601315e-03 | 3 |
| GO:BP | GO:1901798 | positive regulation of signal transduction by p53 class mediator | "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 5 | 2.823384e-03 | 3 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 23 | 3.509177e-03 | 3 |
| GO:BP | GO:0006403 | RNA localization | "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] | 10 | 3.776203e-03 | 3 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 32 | 4.815350e-03 | 3 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 21 | 5.114215e-03 | 3 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 30 | 5.640207e-03 | 3 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 9 | 5.758562e-03 | 3 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 79 | 7.494967e-03 | 3 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 67 | 8.670327e-03 | 3 |
| GO:BP | GO:0017148 | negative regulation of translation | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 8 | 9.832491e-03 | 3 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 22 | 1.197590e-02 | 3 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 68 | 1.493516e-02 | 3 |
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 9 | 1.672892e-02 | 3 |
| GO:BP | GO:0000380 | alternative mRNA splicing, via spliceosome | "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] | 6 | 2.257012e-02 | 3 |
| GO:BP | GO:0016032 | viral process | "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah] | 13 | 2.464426e-02 | 3 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 7 | 3.130139e-02 | 3 |
| GO:BP | GO:0048024 | regulation of mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 7 | 3.130139e-02 | 3 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 14 | 3.241195e-02 | 3 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 11 | 3.283771e-02 | 3 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 15 | 3.625771e-02 | 3 |
| GO:BP | GO:0032986 | protein-DNA complex disassembly | "The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah] | 4 | 3.664508e-02 | 3 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 19 | 3.724444e-02 | 3 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 11 | 3.913631e-02 | 3 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 12 | 4.072805e-02 | 3 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 8 | 4.784774e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 108 | 2.988184e-50 | 3 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 125 | 2.807579e-42 | 3 |
| GO:MF | GO:0003735 | structural constituent of ribosome | "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] | 33 | 2.272467e-20 | 3 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 31 | 5.080024e-20 | 3 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 37 | 9.368700e-12 | 3 |
| GO:MF | GO:0043021 | ribonucleoprotein complex binding | "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] | 17 | 1.610713e-11 | 3 |
| GO:MF | GO:0019843 | rRNA binding | "Binding to a ribosomal RNA." [GOC:jl] | 12 | 9.156120e-11 | 3 |
| GO:MF | GO:0120545 | nucleic acid conformation isomerase activity | "Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-] | 15 | 2.388112e-09 | 3 |
| GO:MF | GO:0004386 | helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] | 14 | 1.450978e-08 | 3 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 146 | 2.715342e-08 | 3 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 16 | 5.622349e-07 | 3 |
| GO:MF | GO:0003724 | RNA helicase activity | "Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098] | 9 | 4.639405e-06 | 3 |
| GO:MF | GO:0008186 | ATP-dependent activity, acting on RNA | "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl] | 9 | 5.862450e-06 | 3 |
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 10 | 1.247359e-05 | 3 |
| GO:MF | GO:0048027 | mRNA 5'-UTR binding | "Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid] | 6 | 1.575473e-05 | 3 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 45 | 2.163994e-05 | 3 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 17 | 4.933020e-05 | 3 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 39 | 7.713640e-05 | 3 |
| GO:MF | GO:0140517 | protein-RNA adaptor activity | "The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way." [PMID:24470144] | 5 | 1.899602e-04 | 3 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 19 | 2.879153e-04 | 3 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 9 | 2.951378e-04 | 3 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 15 | 4.471995e-04 | 3 |
| GO:MF | GO:1990247 | N6-methyladenosine-containing RNA reader activity | "A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625] | 4 | 1.134127e-03 | 3 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 27 | 1.538883e-03 | 3 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 8 | 3.639778e-03 | 3 |
| GO:MF | GO:0031369 | translation initiation factor binding | "Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] | 5 | 4.146029e-03 | 3 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 17 | 4.405604e-03 | 3 |
| GO:MF | GO:0140640 | catalytic activity, acting on a nucleic acid | "Catalytic activity that acts to modify a nucleic acid." [GOC:pg] | 17 | 6.515207e-03 | 3 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 12 | 7.570365e-03 | 3 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 153 | 1.011666e-02 | 3 |
| GO:MF | GO:0008312 | 7S RNA binding | "Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418] | 3 | 1.102363e-02 | 3 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 11 | 1.734168e-02 | 3 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 11 | 2.923507e-02 | 3 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 23 | 2.944458e-02 | 3 |
| GO:MF | GO:1990948 | ubiquitin ligase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a ubiquitin ligase." [GOC:dph, GOC:vw, PMID:21389117] | 3 | 3.716556e-02 | 3 |
| GO:MF | GO:0019789 | SUMO transferase activity | "Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250] | 4 | 4.266769e-02 | 3 |
| GO:MF | GO:0160123 | structural constituent of nuclear lamina | "The action of a molecule that contributes to the structural integrity of nuclear lamina." [PMID:2824113, PMID:31434876] | 2 | 4.289931e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0022626 | cytosolic ribosome | "A ribosome located in the cytosol." [GOC:mtg_sensu] | 35 | 5.331712e-46 | 3 |
| GO:CC | GO:0044391 | ribosomal subunit | "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl] | 35 | 9.729437e-38 | 3 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 109 | 5.888256e-30 | 3 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 96 | 4.176803e-29 | 3 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 116 | 4.782168e-28 | 3 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 116 | 4.854718e-28 | 3 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 114 | 3.190964e-26 | 3 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 114 | 3.190964e-26 | 3 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 114 | 3.190964e-26 | 3 |
| GO:CC | GO:0005840 | ribosome | "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] | 38 | 2.843466e-25 | 3 |
| GO:CC | GO:0022627 | cytosolic small ribosomal subunit | "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 17 | 7.052989e-24 | 3 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 132 | 2.930880e-22 | 3 |
| GO:CC | GO:0022625 | cytosolic large ribosomal subunit | "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 17 | 1.750369e-21 | 3 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 69 | 5.757771e-21 | 3 |
| GO:CC | GO:0015935 | small ribosomal subunit | "The smaller of the two subunits of a ribosome." [GOC:mah] | 18 | 1.782608e-20 | 3 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 153 | 2.582121e-16 | 3 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 90 | 6.055377e-16 | 3 |
| GO:CC | GO:0015934 | large ribosomal subunit | "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] | 17 | 1.344883e-15 | 3 |
| GO:CC | GO:0005730 | nucleolus | "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] | 52 | 3.441687e-15 | 3 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 22 | 1.318040e-14 | 3 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 145 | 1.932595e-13 | 3 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 153 | 3.001532e-13 | 3 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 20 | 6.242523e-13 | 3 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 104 | 8.836185e-13 | 3 |
| GO:CC | GO:0010494 | cytoplasmic stress granule | "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] | 14 | 1.174532e-12 | 3 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 148 | 3.223268e-12 | 3 |
| GO:CC | GO:0030684 | preribosome | "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] | 14 | 8.858890e-12 | 3 |
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 17 | 4.447302e-11 | 3 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 154 | 7.633143e-11 | 3 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 45 | 2.696275e-10 | 3 |
| GO:CC | GO:0071013 | catalytic step 2 spliceosome | "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 12 | 6.021871e-10 | 3 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 21 | 8.565661e-10 | 3 |
| GO:CC | GO:0032040 | small-subunit processome | "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] | 11 | 1.156067e-09 | 3 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 21 | 1.330333e-09 | 3 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 29 | 1.470149e-09 | 3 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 125 | 6.564150e-08 | 3 |
| GO:CC | GO:0070937 | CRD-mediated mRNA stability complex | "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9." [GOC:mah, PMID:19029303] | 4 | 1.172321e-05 | 3 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 33 | 1.364466e-05 | 3 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 41 | 1.421434e-05 | 3 |
| GO:CC | GO:0016607 | nuclear speck | "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640] | 16 | 1.498591e-05 | 3 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 23 | 3.378207e-05 | 3 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 15 | 5.813673e-05 | 3 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 36 | 1.246953e-04 | 3 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 36 | 1.753856e-04 | 3 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 36 | 1.773684e-04 | 3 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 36 | 1.773684e-04 | 3 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 28 | 2.882223e-04 | 3 |
| GO:CC | GO:0000792 | heterochromatin | "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] | 7 | 6.534929e-04 | 3 |
| GO:CC | GO:0106002 | mCRD-mediated mRNA stability complex | "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP." [GOC:bhm, PMID:11051545] | 3 | 1.139398e-03 | 3 |
| GO:CC | GO:0016363 | nuclear matrix | "A dynamic, proteinaceous framework within the nucleus of eukaryotic cells, composed of proteins and RNA, that provides structural support for chromatin organization, gene regulation, and nuclear processes." [PMID:15608168, PMID:3058729, PMID:39789220] | 8 | 1.224435e-03 | 3 |
| GO:CC | GO:0005852 | eukaryotic translation initiation factor 3 complex | "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] | 4 | 1.346793e-03 | 3 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 26 | 1.657432e-03 | 3 |
| GO:CC | GO:0000791 | euchromatin | "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] | 6 | 1.957953e-03 | 3 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 38 | 4.715169e-03 | 3 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 8 | 9.633925e-03 | 3 |
| GO:CC | GO:0032797 | SMN complex | "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415] | 3 | 1.822762e-02 | 3 |
| GO:CC | GO:0042555 | MCM complex | "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] | 3 | 1.822762e-02 | 3 |
| GO:CC | GO:0005791 | rough endoplasmic reticulum | "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] | 5 | 2.337064e-02 | 3 |
| GO:CC | GO:0000932 | P-body | "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603] | 6 | 2.675793e-02 | 3 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 13 | 2.829143e-02 | 3 |
| GO:CC | GO:0015030 | Cajal body | "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] | 6 | 2.984458e-02 | 3 |
| GO:CC | GO:0042382 | paraspeckles | "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299] | 3 | 3.127095e-02 | 3 |
| GO:CC | GO:1990023 | mitotic spindle midzone | "The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw] | 3 | 3.959516e-02 | 3 |
| GO:CC | GO:0051233 | spindle midzone | "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] | 4 | 4.359102e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-156842 | Eukaryotic Translation Elongation | Eukaryotic Translation Elongation | 36 | 3.241863e-45 | 3 |
| REAC | REAC:R-HSA-156902 | Peptide chain elongation | Peptide chain elongation | 35 | 3.834824e-44 | 3 |
| REAC | REAC:R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | SRP-dependent cotranslational protein targeting to membrane | 37 | 1.524208e-43 | 3 |
| REAC | REAC:R-HSA-168273 | Influenza Viral RNA Transcription and Replication | Influenza Viral RNA Transcription and Replication | 38 | 3.264952e-42 | 3 |
| REAC | REAC:R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | L13a-mediated translational silencing of Ceruloplasmin expression | 36 | 6.399192e-42 | 3 |
| REAC | REAC:R-HSA-72689 | Formation of a pool of free 40S subunits | Formation of a pool of free 40S subunits | 35 | 7.877499e-42 | 3 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 64 | 9.123500e-42 | 3 |
| REAC | REAC:R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 34 | 4.296634e-41 | 3 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 36 | 1.160457e-40 | 3 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 36 | 1.160457e-40 | 3 |
| REAC | REAC:R-HSA-192823 | Viral mRNA Translation | Viral mRNA Translation | 33 | 2.192501e-40 | 3 |
| REAC | REAC:R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | GTP hydrolysis and joining of the 60S ribosomal subunit | 35 | 5.409598e-40 | 3 |
| REAC | REAC:R-HSA-2408557 | Selenocysteine synthesis | Selenocysteine synthesis | 33 | 1.241584e-39 | 3 |
| REAC | REAC:R-HSA-72764 | Eukaryotic Translation Termination | Eukaryotic Translation Termination | 33 | 1.241584e-39 | 3 |
| REAC | REAC:R-HSA-168255 | Influenza Infection | Influenza Infection | 38 | 1.765241e-39 | 3 |
| REAC | REAC:R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Response of EIF2AK4 (GCN2) to amino acid deficiency | 33 | 3.057908e-38 | 3 |
| REAC | REAC:R-HSA-927802 | Nonsense-Mediated Decay (NMD) | Nonsense-Mediated Decay (NMD) | 34 | 8.330107e-38 | 3 |
| REAC | REAC:R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 34 | 8.330107e-38 | 3 |
| REAC | REAC:R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Major pathway of rRNA processing in the nucleolus and cytosol | 38 | 1.874467e-36 | 3 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 44 | 2.480002e-36 | 3 |
| REAC | REAC:R-HSA-2408522 | Selenoamino acid metabolism | Selenoamino acid metabolism | 33 | 5.793918e-36 | 3 |
| REAC | REAC:R-HSA-8868773 | rRNA processing in the nucleus and cytosol | rRNA processing in the nucleus and cytosol | 38 | 1.675781e-35 | 3 |
| REAC | REAC:R-HSA-72312 | rRNA processing | rRNA processing | 38 | 1.318090e-34 | 3 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 34 | 1.880878e-31 | 3 |
| REAC | REAC:R-HSA-9711097 | Cellular response to starvation | Cellular response to starvation | 33 | 2.748251e-31 | 3 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 34 | 9.512271e-28 | 3 |
| REAC | REAC:R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | SARS-CoV-1 modulates host translation machinery | 17 | 8.663297e-22 | 3 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 50 | 1.417251e-21 | 3 |
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 19 | 5.668998e-21 | 3 |
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 19 | 8.222727e-21 | 3 |
| REAC | REAC:R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | SARS-CoV-2 modulates host translation machinery | 18 | 1.282225e-20 | 3 |
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 18 | 1.943597e-20 | 3 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 53 | 2.301905e-20 | 3 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 34 | 3.691501e-20 | 3 |
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 18 | 2.770336e-19 | 3 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 45 | 1.095606e-18 | 3 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 45 | 2.217306e-18 | 3 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 36 | 1.869382e-16 | 3 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 36 | 8.180055e-16 | 3 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 62 | 8.326718e-16 | 3 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 17 | 8.285623e-14 | 3 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 19 | 2.696356e-13 | 3 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 60 | 5.262124e-12 | 3 |
| REAC | REAC:R-HSA-9705683 | SARS-CoV-2-host interactions | SARS-CoV-2-host interactions | 19 | 1.562901e-10 | 3 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 46 | 3.450510e-10 | 3 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 21 | 2.521290e-09 | 3 |
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 18 | 2.657930e-09 | 3 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 18 | 4.732724e-09 | 3 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 20 | 7.408935e-09 | 3 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 23 | 3.324968e-07 | 3 |
| REAC | REAC:R-HSA-72165 | mRNA Splicing - Minor Pathway | mRNA Splicing - Minor Pathway | 6 | 5.472447e-03 | 3 |
| REAC | REAC:R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | Signaling by ALK fusions and activated point mutants | 7 | 2.224294e-02 | 3 |
| REAC | REAC:R-HSA-9700206 | Signaling by ALK in cancer | Signaling by ALK in cancer | 7 | 2.224294e-02 | 3 |
| REAC | REAC:R-HSA-9629569 | Protein hydroxylation | Protein hydroxylation | 4 | 2.450531e-02 | 3 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 15 | 4.282849e-02 | 3 |
| REAC | REAC:R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins | SUMO E3 ligases SUMOylate target proteins | 9 | 4.749135e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP477 | Cytoplasmic ribosomal proteins | Cytoplasmic ribosomal proteins | 33 | 3.763004e-39 | 3 |
| WP | WP:WP411 | mRNA processing | mRNA processing | 18 | 3.575889e-12 | 3 |
| WP | WP:WP107 | Translation factors | Translation factors | 6 | 7.363335e-03 | 3 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 16 | 2.040298e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3055 | Nop56p-associated pre-rRNA complex | Nop56p-associated pre-rRNA complex | 36 | 5.338110e-33 | 3 |
| CORUM | CORUM:306 | Ribosome, cytoplasmic | Ribosome, cytoplasmic | 30 | 1.467307e-27 | 3 |
| CORUM | CORUM:338 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 15 | 1.034637e-14 | 3 |
| CORUM | CORUM:305 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 15 | 3.843107e-14 | 3 |
| CORUM | CORUM:308 | 60S ribosomal subunit, cytoplasmic | 60S ribosomal subunit, cytoplasmic | 15 | 1.502700e-11 | 3 |
| CORUM | CORUM:1181 | C complex spliceosome | C complex spliceosome | 11 | 1.018023e-03 | 3 |
| CORUM | CORUM:1332 | Large Drosha complex | Large Drosha complex | 6 | 2.175190e-03 | 3 |
| CORUM | CORUM:6838 | IGF2BP1 complex | IGF2BP1 complex | 4 | 1.346663e-02 | 3 |
| CORUM | CORUM:3082 | DGCR8 multiprotein complex | DGCR8 multiprotein complex | 4 | 2.198884e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03010 | Ribosome | Ribosome | 33 | 4.947279e-32 | 3 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | Coronavirus disease - COVID-19 | 34 | 3.819563e-27 | 3 |
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 11 | 4.501105e-04 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 99 | 2.255069e-19 | 3 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 103 | 6.159622e-19 | 3 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 66 | 9.634741e-19 | 3 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 69 | 3.037180e-18 | 3 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 51 | 3.983103e-17 | 3 |
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 69 | 8.740231e-17 | 3 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 110 | 3.579940e-16 | 3 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 59 | 3.772147e-16 | 3 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 52 | 4.435674e-16 | 3 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 53 | 2.251752e-15 | 3 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 51 | 4.292020e-15 | 3 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 97 | 4.388786e-15 | 3 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 122 | 8.120249e-15 | 3 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 57 | 1.407557e-14 | 3 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 54 | 1.602958e-14 | 3 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 52 | 3.328155e-14 | 3 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 107 | 5.293052e-14 | 3 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 62 | 6.671005e-14 | 3 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 111 | 6.701264e-14 | 3 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 53 | 1.364507e-13 | 3 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 72 | 1.446785e-13 | 3 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 55 | 1.567549e-13 | 3 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 98 | 2.876528e-13 | 3 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 87 | 4.769493e-13 | 3 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 84 | 5.152113e-13 | 3 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 94 | 6.953460e-13 | 3 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 104 | 8.241103e-13 | 3 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 76 | 1.347274e-12 | 3 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 55 | 2.381154e-12 | 3 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 114 | 2.728493e-12 | 3 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 38 | 4.225065e-12 | 3 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 103 | 7.449901e-12 | 3 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 94 | 8.726916e-12 | 3 |
| HPA | HPA:0380000 | Placenta | Placenta | 126 | 1.096108e-11 | 3 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 95 | 1.540313e-11 | 3 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 94 | 1.542976e-11 | 3 |
| HPA | HPA:0620000 | Vagina | Vagina | 113 | 1.563240e-11 | 3 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 113 | 1.563240e-11 | 3 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 52 | 2.367407e-11 | 3 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 101 | 2.579750e-11 | 3 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 35 | 2.916623e-11 | 3 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 90 | 3.555702e-11 | 3 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 113 | 4.023084e-11 | 3 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 39 | 6.252765e-11 | 3 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 40 | 7.063364e-11 | 3 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 44 | 7.186051e-11 | 3 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 91 | 8.512367e-11 | 3 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 39 | 9.011427e-11 | 3 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 61 | 9.534048e-11 | 3 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 36 | 1.048306e-10 | 3 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 118 | 1.165023e-10 | 3 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 118 | 1.165023e-10 | 3 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 89 | 1.274106e-10 | 3 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 64 | 1.304313e-10 | 3 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 123 | 1.643445e-10 | 3 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 123 | 1.643445e-10 | 3 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 111 | 1.677520e-10 | 3 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 23 | 1.795576e-10 | 3 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 85 | 2.029563e-10 | 3 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 104 | 2.316807e-10 | 3 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 90 | 2.859254e-10 | 3 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 124 | 2.899963e-10 | 3 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 91 | 3.139043e-10 | 3 |
| HPA | HPA:0500653 | Soft tissue 1; fibroblasts[High] | Soft tissue 1; fibroblasts[High] | 30 | 3.224327e-10 | 3 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 33 | 3.741481e-10 | 3 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 117 | 3.821656e-10 | 3 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 34 | 5.130139e-10 | 3 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 31 | 5.730022e-10 | 3 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 34 | 6.251686e-10 | 3 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 40 | 6.867999e-10 | 3 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 30 | 7.130780e-10 | 3 |
| HPA | HPA:0060103 | Bronchus; respiratory epithelial cells[High] | Bronchus; respiratory epithelial cells[High] | 56 | 7.157451e-10 | 3 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 32 | 7.485318e-10 | 3 |
| HPA | HPA:0630000 | Cervix | Cervix | 119 | 7.527691e-10 | 3 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 119 | 9.684227e-10 | 3 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 70 | 1.029747e-09 | 3 |
| HPA | HPA:0050000 | Breast | Breast | 121 | 1.048299e-09 | 3 |
| HPA | HPA:0400000 | Rectum | Rectum | 127 | 1.076368e-09 | 3 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 39 | 1.442991e-09 | 3 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 111 | 1.836231e-09 | 3 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 100 | 2.523585e-09 | 3 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 112 | 2.752541e-09 | 3 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 112 | 2.752541e-09 | 3 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 102 | 3.097307e-09 | 3 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 117 | 3.643679e-09 | 3 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 33 | 3.724389e-09 | 3 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 125 | 4.060861e-09 | 3 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 31 | 4.348505e-09 | 3 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 29 | 5.052171e-09 | 3 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 100 | 5.064813e-09 | 3 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 34 | 9.283378e-09 | 3 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 51 | 9.488976e-09 | 3 |
| HPA | HPA:0630053 | Cervix; glandular cells[High] | Cervix; glandular cells[High] | 42 | 1.219174e-08 | 3 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 53 | 1.314232e-08 | 3 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 125 | 1.352603e-08 | 3 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 91 | 1.434886e-08 | 3 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 34 | 1.450540e-08 | 3 |
| HPA | HPA:0530000 | Spleen | Spleen | 107 | 1.878084e-08 | 3 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 101 | 1.895192e-08 | 3 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 121 | 2.124345e-08 | 3 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 123 | 2.442228e-08 | 3 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 123 | 2.442228e-08 | 3 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 110 | 2.737016e-08 | 3 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 30 | 2.908313e-08 | 3 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 63 | 3.361998e-08 | 3 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 67 | 3.464594e-08 | 3 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 25 | 4.154813e-08 | 3 |
| HPA | HPA:0050093 | Breast; myoepithelial cells[High] | Breast; myoepithelial cells[High] | 34 | 4.605571e-08 | 3 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 28 | 5.018996e-08 | 3 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 116 | 5.134802e-08 | 3 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 116 | 5.134802e-08 | 3 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 119 | 5.440807e-08 | 3 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 31 | 6.699486e-08 | 3 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 26 | 7.307559e-08 | 3 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 115 | 7.973331e-08 | 3 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 115 | 7.973331e-08 | 3 |
| HPA | HPA:0510703 | Soft tissue 2; peripheral nerve[High] | Soft tissue 2; peripheral nerve[High] | 20 | 8.217277e-08 | 3 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 114 | 8.445152e-08 | 3 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 41 | 9.658519e-08 | 3 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 56 | 9.734887e-08 | 3 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 31 | 9.799966e-08 | 3 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 20 | 9.843260e-08 | 3 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 124 | 1.036753e-07 | 3 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 94 | 1.381725e-07 | 3 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 98 | 1.657755e-07 | 3 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 33 | 1.754315e-07 | 3 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 109 | 2.053705e-07 | 3 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 105 | 2.059774e-07 | 3 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 105 | 2.059774e-07 | 3 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 102 | 2.332717e-07 | 3 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 29 | 2.492018e-07 | 3 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 111 | 2.494846e-07 | 3 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 111 | 2.494846e-07 | 3 |
| HPA | HPA:0490693 | Smooth muscle; smooth muscle cells[High] | Smooth muscle; smooth muscle cells[High] | 28 | 2.593682e-07 | 3 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 20 | 3.107199e-07 | 3 |
| HPA | HPA:0471492 | Skin 2; vascular mural cells[≥Medium] | Skin 2; vascular mural cells[≥Medium] | 16 | 3.170271e-07 | 3 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 103 | 3.477787e-07 | 3 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 77 | 3.700240e-07 | 3 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 22 | 4.484073e-07 | 3 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 109 | 4.789627e-07 | 3 |
| HPA | HPA:0160253 | Endometrium 1; cells in endometrial stroma[High] | Endometrium 1; cells in endometrial stroma[High] | 23 | 5.247757e-07 | 3 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 29 | 5.304525e-07 | 3 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 121 | 5.452091e-07 | 3 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 121 | 5.452091e-07 | 3 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 117 | 5.612069e-07 | 3 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 36 | 5.878444e-07 | 3 |
| HPA | HPA:0510653 | Soft tissue 2; fibroblasts[High] | Soft tissue 2; fibroblasts[High] | 25 | 6.997184e-07 | 3 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 81 | 7.500713e-07 | 3 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 81 | 7.500713e-07 | 3 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 28 | 7.749677e-07 | 3 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 18 | 7.897976e-07 | 3 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 22 | 8.203280e-07 | 3 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 29 | 8.437670e-07 | 3 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 30 | 8.866921e-07 | 3 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 114 | 9.371048e-07 | 3 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 112 | 9.408111e-07 | 3 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 16 | 9.513066e-07 | 3 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 51 | 9.699613e-07 | 3 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 53 | 9.921882e-07 | 3 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 113 | 1.006010e-06 | 3 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 34 | 1.058136e-06 | 3 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 26 | 1.077224e-06 | 3 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 31 | 1.082945e-06 | 3 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 113 | 1.135203e-06 | 3 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 120 | 1.243922e-06 | 3 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 120 | 1.243922e-06 | 3 |
| HPA | HPA:0470683 | Skin 2; epidermal cells[High] | Skin 2; epidermal cells[High] | 36 | 1.249586e-06 | 3 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 34 | 1.279238e-06 | 3 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 115 | 1.374331e-06 | 3 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 83 | 1.416455e-06 | 3 |
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 41 | 1.561894e-06 | 3 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 12 | 1.636059e-06 | 3 |
| HPA | HPA:0570773 | Testis; peritubular cells[High] | Testis; peritubular cells[High] | 16 | 1.880062e-06 | 3 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 16 | 2.008437e-06 | 3 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 61 | 2.206962e-06 | 3 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 25 | 2.343870e-06 | 3 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 19 | 2.408300e-06 | 3 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 57 | 2.689187e-06 | 3 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 82 | 3.082767e-06 | 3 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 110 | 3.367569e-06 | 3 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 31 | 3.651053e-06 | 3 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 114 | 3.695641e-06 | 3 |
| HPA | HPA:0570783 | Testis; preleptotene spermatocytes[High] | Testis; preleptotene spermatocytes[High] | 29 | 4.392064e-06 | 3 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 90 | 4.448304e-06 | 3 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 38 | 4.739767e-06 | 3 |
| HPA | HPA:0351183 | Pancreas; pancreatic endocrine cells[High] | Pancreas; pancreatic endocrine cells[High] | 30 | 4.867146e-06 | 3 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 100 | 5.040243e-06 | 3 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 75 | 5.087741e-06 | 3 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 105 | 5.306133e-06 | 3 |
| HPA | HPA:0340000 | Ovary | Ovary | 97 | 5.873203e-06 | 3 |
| HPA | HPA:0400651 | Rectum; fibroblasts[≥Low] | Rectum; fibroblasts[≥Low] | 12 | 6.598216e-06 | 3 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 63 | 6.673284e-06 | 3 |
| HPA | HPA:0400053 | Rectum; glandular cells[High] | Rectum; glandular cells[High] | 60 | 6.837793e-06 | 3 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 117 | 6.949554e-06 | 3 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 115 | 7.086937e-06 | 3 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 117 | 7.538601e-06 | 3 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 16 | 7.881886e-06 | 3 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 38 | 7.899731e-06 | 3 |
| HPA | HPA:0030053 | Appendix; glandular cells[High] | Appendix; glandular cells[High] | 49 | 8.904468e-06 | 3 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 26 | 8.914506e-06 | 3 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 64 | 9.127922e-06 | 3 |
| HPA | HPA:0440343 | Skeletal muscle; myocytes[High] | Skeletal muscle; myocytes[High] | 31 | 9.692362e-06 | 3 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 20 | 9.830732e-06 | 3 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 116 | 1.030681e-05 | 3 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 116 | 1.030681e-05 | 3 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 43 | 1.129118e-05 | 3 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 31 | 1.194893e-05 | 3 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 61 | 1.204868e-05 | 3 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 82 | 1.209373e-05 | 3 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 12 | 1.237754e-05 | 3 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 16 | 1.248545e-05 | 3 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 16 | 1.248545e-05 | 3 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 31 | 1.258553e-05 | 3 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 31 | 1.291563e-05 | 3 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 76 | 1.316187e-05 | 3 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 99 | 1.382976e-05 | 3 |
| HPA | HPA:0170253 | Endometrium 2; cells in endometrial stroma[High] | Endometrium 2; cells in endometrial stroma[High] | 19 | 1.467326e-05 | 3 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 54 | 1.651904e-05 | 3 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 90 | 1.803991e-05 | 3 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 65 | 1.832943e-05 | 3 |
| HPA | HPA:0080000 | Caudate | Caudate | 112 | 1.838378e-05 | 3 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 66 | 1.882876e-05 | 3 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 12 | 2.057603e-05 | 3 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 109 | 2.109546e-05 | 3 |
| HPA | HPA:0390000 | Prostate | Prostate | 109 | 2.109546e-05 | 3 |
| HPA | HPA:0290000 | Liver | Liver | 105 | 2.368229e-05 | 3 |
| HPA | HPA:0130000 | Colon | Colon | 124 | 2.380971e-05 | 3 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 102 | 2.441860e-05 | 3 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 91 | 2.737822e-05 | 3 |
| HPA | HPA:0150053 | Duodenum; glandular cells[High] | Duodenum; glandular cells[High] | 59 | 2.850038e-05 | 3 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 116 | 3.160385e-05 | 3 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 41 | 3.254952e-05 | 3 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 33 | 3.432335e-05 | 3 |
| HPA | HPA:0010013 | Adipose tissue; adipocytes[High] | Adipose tissue; adipocytes[High] | 21 | 3.483541e-05 | 3 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 24 | 3.832974e-05 | 3 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 47 | 3.849542e-05 | 3 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 34 | 3.994650e-05 | 3 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 87 | 4.095493e-05 | 3 |
| HPA | HPA:0570782 | Testis; preleptotene spermatocytes[≥Medium] | Testis; preleptotene spermatocytes[≥Medium] | 41 | 4.560205e-05 | 3 |
| HPA | HPA:0530712 | Spleen; cells in red pulp[≥Medium] | Spleen; cells in red pulp[≥Medium] | 66 | 5.728444e-05 | 3 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 48 | 6.248564e-05 | 3 |
| HPA | HPA:0030000 | Appendix | Appendix | 119 | 6.528958e-05 | 3 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 109 | 6.716914e-05 | 3 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 18 | 7.003965e-05 | 3 |
| HPA | HPA:0130203 | Colon; endothelial cells[High] | Colon; endothelial cells[High] | 29 | 7.133929e-05 | 3 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 97 | 7.299228e-05 | 3 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 96 | 7.441582e-05 | 3 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 15 | 7.825409e-05 | 3 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 19 | 7.999573e-05 | 3 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 40 | 8.941456e-05 | 3 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 13 | 1.180421e-04 | 3 |
| HPA | HPA:0461452 | Skin 1; hair follicles[≥Medium] | Skin 1; hair follicles[≥Medium] | 16 | 1.228465e-04 | 3 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 104 | 1.310114e-04 | 3 |
| HPA | HPA:0130651 | Colon; fibroblasts[≥Low] | Colon; fibroblasts[≥Low] | 10 | 1.503198e-04 | 3 |
| HPA | HPA:0300000 | Lung | Lung | 114 | 1.600104e-04 | 3 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 97 | 1.758451e-04 | 3 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 84 | 1.808356e-04 | 3 |
| HPA | HPA:0390053 | Prostate; glandular cells[High] | Prostate; glandular cells[High] | 37 | 1.921042e-04 | 3 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 20 | 1.981506e-04 | 3 |
| HPA | HPA:0460663 | Skin 1; keratinocytes[High] | Skin 1; keratinocytes[High] | 24 | 1.998799e-04 | 3 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 17 | 2.048349e-04 | 3 |
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 85 | 2.218372e-04 | 3 |
| HPA | HPA:0510652 | Soft tissue 2; fibroblasts[≥Medium] | Soft tissue 2; fibroblasts[≥Medium] | 57 | 2.253510e-04 | 3 |
| HPA | HPA:0270353 | Kidney; cells in glomeruli[High] | Kidney; cells in glomeruli[High] | 28 | 2.379856e-04 | 3 |
| HPA | HPA:0050013 | Breast; adipocytes[High] | Breast; adipocytes[High] | 16 | 2.606180e-04 | 3 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 86 | 2.842886e-04 | 3 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 76 | 2.944064e-04 | 3 |
| HPA | HPA:0570792 | Testis; round or early spermatids[≥Medium] | Testis; round or early spermatids[≥Medium] | 46 | 3.183773e-04 | 3 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 93 | 3.244385e-04 | 3 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 93 | 3.244385e-04 | 3 |
| HPA | HPA:0050012 | Breast; adipocytes[≥Medium] | Breast; adipocytes[≥Medium] | 39 | 3.673116e-04 | 3 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 12 | 3.901337e-04 | 3 |
| HPA | HPA:0270362 | Kidney; cells in tubules[≥Medium] | Kidney; cells in tubules[≥Medium] | 97 | 3.993344e-04 | 3 |
| HPA | HPA:0570791 | Testis; round or early spermatids[≥Low] | Testis; round or early spermatids[≥Low] | 52 | 4.312698e-04 | 3 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 17 | 5.010990e-04 | 3 |
| HPA | HPA:0461451 | Skin 1; hair follicles[≥Low] | Skin 1; hair follicles[≥Low] | 17 | 5.201063e-04 | 3 |
| HPA | HPA:0400891 | Rectum; goblet cells[≥Low] | Rectum; goblet cells[≥Low] | 18 | 5.448390e-04 | 3 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 96 | 5.510460e-04 | 3 |
| HPA | HPA:0130892 | Colon; goblet cells[≥Medium] | Colon; goblet cells[≥Medium] | 16 | 7.477140e-04 | 3 |
| HPA | HPA:0570000 | Testis | Testis | 127 | 7.606900e-04 | 3 |
| HPA | HPA:0570803 | Testis; sertoli cells[High] | Testis; sertoli cells[High] | 22 | 7.705439e-04 | 3 |
| HPA | HPA:0131302 | Colon; enterocytes[≥Medium] | Colon; enterocytes[≥Medium] | 17 | 8.339998e-04 | 3 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 71 | 8.488171e-04 | 3 |
| HPA | HPA:0461393 | Skin 1; cells in basal layer[High] | Skin 1; cells in basal layer[High] | 12 | 8.670031e-04 | 3 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 14 | 8.675273e-04 | 3 |
| HPA | HPA:0401301 | Rectum; enterocytes[≥Low] | Rectum; enterocytes[≥Low] | 20 | 8.740531e-04 | 3 |
| HPA | HPA:0381192 | Placenta; cytotrophoblasts[≥Medium] | Placenta; cytotrophoblasts[≥Medium] | 18 | 8.756658e-04 | 3 |
| HPA | HPA:0400242 | Rectum; peripheral nerve/ganglion[≥Medium] | Rectum; peripheral nerve/ganglion[≥Medium] | 12 | 9.153749e-04 | 3 |
| HPA | HPA:0400203 | Rectum; endothelial cells[High] | Rectum; endothelial cells[High] | 9 | 9.902378e-04 | 3 |
| HPA | HPA:0360053 | Parathyroid gland; glandular cells[High] | Parathyroid gland; glandular cells[High] | 39 | 1.002610e-03 | 3 |
| HPA | HPA:0570772 | Testis; peritubular cells[≥Medium] | Testis; peritubular cells[≥Medium] | 20 | 1.275587e-03 | 3 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 94 | 1.287547e-03 | 3 |
| HPA | HPA:0130653 | Colon; fibroblasts[High] | Colon; fibroblasts[High] | 7 | 1.367527e-03 | 3 |
| HPA | HPA:0570771 | Testis; peritubular cells[≥Low] | Testis; peritubular cells[≥Low] | 24 | 1.398646e-03 | 3 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 88 | 1.429109e-03 | 3 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 50 | 1.484223e-03 | 3 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 15 | 1.504952e-03 | 3 |
| HPA | HPA:0131292 | Colon; endocrine cells[≥Medium] | Colon; endocrine cells[≥Medium] | 17 | 1.712275e-03 | 3 |
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 44 | 1.721880e-03 | 3 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 13 | 1.873377e-03 | 3 |
| HPA | HPA:0031302 | Appendix; enterocytes[≥Medium] | Appendix; enterocytes[≥Medium] | 16 | 1.939434e-03 | 3 |
| HPA | HPA:0500113 | Soft tissue 1; chondrocytes[High] | Soft tissue 1; chondrocytes[High] | 15 | 1.964677e-03 | 3 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 88 | 2.022214e-03 | 3 |
| HPA | HPA:0381203 | Placenta; hofbauer cells[High] | Placenta; hofbauer cells[High] | 14 | 2.030574e-03 | 3 |
| HPA | HPA:0291163 | Liver; cholangiocytes[High] | Liver; cholangiocytes[High] | 15 | 2.039676e-03 | 3 |
| HPA | HPA:0401331 | Rectum; mucosal lymphoid cells[≥Low] | Rectum; mucosal lymphoid cells[≥Low] | 20 | 2.108299e-03 | 3 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 109 | 2.153008e-03 | 3 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 109 | 2.153008e-03 | 3 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 96 | 2.218013e-03 | 3 |
| HPA | HPA:0130891 | Colon; goblet cells[≥Low] | Colon; goblet cells[≥Low] | 17 | 2.446909e-03 | 3 |
| HPA | HPA:0131301 | Colon; enterocytes[≥Low] | Colon; enterocytes[≥Low] | 19 | 2.628711e-03 | 3 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 78 | 2.679014e-03 | 3 |
| HPA | HPA:0400653 | Rectum; fibroblasts[High] | Rectum; fibroblasts[High] | 7 | 2.694520e-03 | 3 |
| HPA | HPA:0151352 | Duodenum; paneth cells[≥Medium] | Duodenum; paneth cells[≥Medium] | 13 | 2.900413e-03 | 3 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 80 | 2.921933e-03 | 3 |
| HPA | HPA:0130202 | Colon; endothelial cells[≥Medium] | Colon; endothelial cells[≥Medium] | 69 | 2.969196e-03 | 3 |
| HPA | HPA:0131331 | Colon; mucosal lymphoid cells[≥Low] | Colon; mucosal lymphoid cells[≥Low] | 19 | 3.022783e-03 | 3 |
| HPA | HPA:0400201 | Rectum; endothelial cells[≥Low] | Rectum; endothelial cells[≥Low] | 13 | 3.157046e-03 | 3 |
| HPA | HPA:0130053 | Colon; glandular cells[High] | Colon; glandular cells[High] | 51 | 3.272441e-03 | 3 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 15 | 3.275149e-03 | 3 |
| HPA | HPA:0381193 | Placenta; cytotrophoblasts[High] | Placenta; cytotrophoblasts[High] | 14 | 3.389589e-03 | 3 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 81 | 3.430882e-03 | 3 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 118 | 3.489396e-03 | 3 |
| HPA | HPA:0030073 | Appendix; lymphoid tissue[High] | Appendix; lymphoid tissue[High] | 24 | 3.546523e-03 | 3 |
| HPA | HPA:0460642 | Skin 1; Langerhans[≥Medium] | Skin 1; Langerhans[≥Medium] | 54 | 3.608091e-03 | 3 |
| HPA | HPA:0381202 | Placenta; hofbauer cells[≥Medium] | Placenta; hofbauer cells[≥Medium] | 16 | 3.682099e-03 | 3 |
| HPA | HPA:0400202 | Rectum; endothelial cells[≥Medium] | Rectum; endothelial cells[≥Medium] | 11 | 3.818048e-03 | 3 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 17 | 3.901572e-03 | 3 |
| HPA | HPA:0570761 | Testis; pachytene spermatocytes[≥Low] | Testis; pachytene spermatocytes[≥Low] | 50 | 4.041185e-03 | 3 |
| HPA | HPA:0481351 | Small intestine; paneth cells[≥Low] | Small intestine; paneth cells[≥Low] | 13 | 4.050992e-03 | 3 |
| HPA | HPA:0270000 | Kidney | Kidney | 119 | 4.193256e-03 | 3 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 89 | 4.278908e-03 | 3 |
| HPA | HPA:0381191 | Placenta; cytotrophoblasts[≥Low] | Placenta; cytotrophoblasts[≥Low] | 18 | 4.305118e-03 | 3 |
| HPA | HPA:0481352 | Small intestine; paneth cells[≥Medium] | Small intestine; paneth cells[≥Medium] | 12 | 4.822717e-03 | 3 |
| HPA | HPA:0131333 | Colon; mucosal lymphoid cells[High] | Colon; mucosal lymphoid cells[High] | 10 | 4.961328e-03 | 3 |
| HPA | HPA:0401303 | Rectum; enterocytes[High] | Rectum; enterocytes[High] | 12 | 5.039977e-03 | 3 |
| HPA | HPA:0381201 | Placenta; hofbauer cells[≥Low] | Placenta; hofbauer cells[≥Low] | 17 | 5.107481e-03 | 3 |
| HPA | HPA:0130652 | Colon; fibroblasts[≥Medium] | Colon; fibroblasts[≥Medium] | 8 | 5.329143e-03 | 3 |
| HPA | HPA:0400052 | Rectum; glandular cells[≥Medium] | Rectum; glandular cells[≥Medium] | 97 | 5.785483e-03 | 3 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 17 | 5.912388e-03 | 3 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 83 | 6.577895e-03 | 3 |
| HPA | HPA:0131291 | Colon; endocrine cells[≥Low] | Colon; endocrine cells[≥Low] | 17 | 6.635827e-03 | 3 |
| HPA | HPA:0530723 | Spleen; cells in white pulp[High] | Spleen; cells in white pulp[High] | 25 | 6.711410e-03 | 3 |
| HPA | HPA:0480053 | Small intestine; glandular cells[High] | Small intestine; glandular cells[High] | 52 | 6.850996e-03 | 3 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 91 | 7.110140e-03 | 3 |
| HPA | HPA:0400051 | Rectum; glandular cells[≥Low] | Rectum; glandular cells[≥Low] | 107 | 7.371763e-03 | 3 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 16 | 7.570612e-03 | 3 |
| HPA | HPA:0461482 | Skin 1; sebaceous glands[≥Medium] | Skin 1; sebaceous glands[≥Medium] | 10 | 8.061293e-03 | 3 |
| HPA | HPA:0151351 | Duodenum; paneth cells[≥Low] | Duodenum; paneth cells[≥Low] | 13 | 8.204299e-03 | 3 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 88 | 8.820074e-03 | 3 |
| HPA | HPA:0500703 | Soft tissue 1; peripheral nerve[High] | Soft tissue 1; peripheral nerve[High] | 12 | 9.111734e-03 | 3 |
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 42 | 9.670148e-03 | 3 |
| HPA | HPA:0031292 | Appendix; endocrine cells[≥Medium] | Appendix; endocrine cells[≥Medium] | 15 | 9.839170e-03 | 3 |
| HPA | HPA:0481303 | Small intestine; enterocytes[High] | Small intestine; enterocytes[High] | 12 | 1.070517e-02 | 3 |
| HPA | HPA:0530713 | Spleen; cells in red pulp[High] | Spleen; cells in red pulp[High] | 24 | 1.126495e-02 | 3 |
| HPA | HPA:0270361 | Kidney; cells in tubules[≥Low] | Kidney; cells in tubules[≥Low] | 106 | 1.175498e-02 | 3 |
| HPA | HPA:0100203 | Cerebral cortex; endothelial cells[High] | Cerebral cortex; endothelial cells[High] | 16 | 1.176145e-02 | 3 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 82 | 1.186196e-02 | 3 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 46 | 1.242529e-02 | 3 |
| HPA | HPA:0400893 | Rectum; goblet cells[High] | Rectum; goblet cells[High] | 11 | 1.348051e-02 | 3 |
| HPA | HPA:0241103 | Heart muscle; cardiomyocytes[High] | Heart muscle; cardiomyocytes[High] | 30 | 1.359010e-02 | 3 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 89 | 1.372723e-02 | 3 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 14 | 1.385492e-02 | 3 |
| HPA | HPA:0481301 | Small intestine; enterocytes[≥Low] | Small intestine; enterocytes[≥Low] | 19 | 1.440296e-02 | 3 |
| HPA | HPA:0490692 | Smooth muscle; smooth muscle cells[≥Medium] | Smooth muscle; smooth muscle cells[≥Medium] | 59 | 1.517968e-02 | 3 |
| HPA | HPA:0030891 | Appendix; goblet cells[≥Low] | Appendix; goblet cells[≥Low] | 15 | 1.648416e-02 | 3 |
| HPA | HPA:0131303 | Colon; enterocytes[High] | Colon; enterocytes[High] | 11 | 1.665474e-02 | 3 |
| HPA | HPA:0480892 | Small intestine; goblet cells[≥Medium] | Small intestine; goblet cells[≥Medium] | 14 | 1.678581e-02 | 3 |
| HPA | HPA:0460662 | Skin 1; keratinocytes[≥Medium] | Skin 1; keratinocytes[≥Medium] | 61 | 1.696505e-02 | 3 |
| HPA | HPA:0100202 | Cerebral cortex; endothelial cells[≥Medium] | Cerebral cortex; endothelial cells[≥Medium] | 50 | 1.702077e-02 | 3 |
| HPA | HPA:0400241 | Rectum; peripheral nerve/ganglion[≥Low] | Rectum; peripheral nerve/ganglion[≥Low] | 12 | 1.903225e-02 | 3 |
| HPA | HPA:0270352 | Kidney; cells in glomeruli[≥Medium] | Kidney; cells in glomeruli[≥Medium] | 58 | 2.178871e-02 | 3 |
| HPA | HPA:0570733 | Testis; Leydig cells[High] | Testis; Leydig cells[High] | 39 | 2.285810e-02 | 3 |
| HPA | HPA:0211092 | Fallopian tube; non-ciliated cells[≥Medium] | Fallopian tube; non-ciliated cells[≥Medium] | 19 | 2.333679e-02 | 3 |
| HPA | HPA:0030432 | Appendix; germinal center cells[≥Medium] | Appendix; germinal center cells[≥Medium] | 11 | 2.400043e-02 | 3 |
| HPA | HPA:0401293 | Rectum; endocrine cells[High] | Rectum; endocrine cells[High] | 12 | 2.542251e-02 | 3 |
| HPA | HPA:0031303 | Appendix; enterocytes[High] | Appendix; enterocytes[High] | 10 | 2.543518e-02 | 3 |
| HPA | HPA:0090183 | Cerebellum; cells in granular layer[High] | Cerebellum; cells in granular layer[High] | 22 | 2.582056e-02 | 3 |
| HPA | HPA:0401291 | Rectum; endocrine cells[≥Low] | Rectum; endocrine cells[≥Low] | 16 | 2.736674e-02 | 3 |
| HPA | HPA:0150891 | Duodenum; goblet cells[≥Low] | Duodenum; goblet cells[≥Low] | 15 | 2.831066e-02 | 3 |
| HPA | HPA:0461453 | Skin 1; hair follicles[High] | Skin 1; hair follicles[High] | 8 | 2.975793e-02 | 3 |
| HPA | HPA:0500702 | Soft tissue 1; peripheral nerve[≥Medium] | Soft tissue 1; peripheral nerve[≥Medium] | 32 | 3.178645e-02 | 3 |
| HPA | HPA:0480891 | Small intestine; goblet cells[≥Low] | Small intestine; goblet cells[≥Low] | 15 | 3.333850e-02 | 3 |
| HPA | HPA:0510702 | Soft tissue 2; peripheral nerve[≥Medium] | Soft tissue 2; peripheral nerve[≥Medium] | 35 | 3.340708e-02 | 3 |
| HPA | HPA:0130241 | Colon; peripheral nerve/ganglion[≥Low] | Colon; peripheral nerve/ganglion[≥Low] | 82 | 3.979510e-02 | 3 |
| HPA | HPA:0460653 | Skin 1; fibroblasts[High] | Skin 1; fibroblasts[High] | 20 | 4.194025e-02 | 3 |
| HPA | HPA:0130052 | Colon; glandular cells[≥Medium] | Colon; glandular cells[≥Medium] | 93 | 4.228322e-02 | 3 |
| HPA | HPA:0031291 | Appendix; endocrine cells[≥Low] | Appendix; endocrine cells[≥Low] | 15 | 4.233891e-02 | 3 |
| HPA | HPA:0461481 | Skin 1; sebaceous glands[≥Low] | Skin 1; sebaceous glands[≥Low] | 10 | 4.401874e-02 | 3 |
| HPA | HPA:0130893 | Colon; goblet cells[High] | Colon; goblet cells[High] | 10 | 4.964120e-02 | 3 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 14 | 4.989290e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 44 | 2.885545e-17 | 3 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 40 | 3.462329e-09 | 3 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 42 | 1.142443e-08 | 3 |
| MIRNA | MIRNA:hsa-mir-1296-5p | hsa-mir-1296-5p | hsa-mir-1296-5p | 11 | 5.850082e-06 | 3 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 22 | 1.008710e-05 | 3 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 24 | 2.470346e-04 | 3 |
| MIRNA | MIRNA:hsa-let-7c-3p | hsa-let-7c-3p | hsa-let-7c-3p | 8 | 1.693810e-03 | 3 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 15 | 2.581428e-03 | 3 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 35 | 2.620126e-03 | 3 |
| MIRNA | MIRNA:hsa-mir-505-3p | hsa-mir-505-3p | hsa-mir-505-3p | 11 | 3.022024e-03 | 3 |
| MIRNA | MIRNA:hsa-mir-191-5p | hsa-mir-191-5p | hsa-mir-191-5p | 7 | 4.648736e-03 | 3 |
| MIRNA | MIRNA:hsa-mir-423-3p | hsa-mir-423-3p | hsa-mir-423-3p | 14 | 5.075572e-03 | 3 |
| MIRNA | MIRNA:hsa-mir-149-5p | hsa-mir-149-5p | hsa-mir-149-5p | 14 | 7.618601e-03 | 3 |
| MIRNA | MIRNA:hsa-mir-1273d | hsa-mir-1273d | hsa-mir-1273d | 18 | 8.826034e-03 | 3 |
| MIRNA | MIRNA:hsa-mir-100-5p | hsa-mir-100-5p | hsa-mir-100-5p | 11 | 1.185520e-02 | 3 |
| MIRNA | MIRNA:hsa-mir-92b-3p | hsa-mir-92b-3p | hsa-mir-92b-3p | 18 | 1.316664e-02 | 3 |
| MIRNA | MIRNA:hsa-mir-652-3p | hsa-mir-652-3p | hsa-mir-652-3p | 8 | 1.909034e-02 | 3 |
| MIRNA | MIRNA:hsa-mir-186-5p | hsa-mir-186-5p | hsa-mir-186-5p | 19 | 2.179415e-02 | 3 |
| MIRNA | MIRNA:hsa-mir-15b-5p | hsa-mir-15b-5p | hsa-mir-15b-5p | 19 | 2.909826e-02 | 3 |
| MIRNA | MIRNA:hsa-mir-6729-5p | hsa-mir-6729-5p | hsa-mir-6729-5p | 6 | 3.075724e-02 | 3 |
| MIRNA | MIRNA:hsa-mir-34a-5p | hsa-mir-34a-5p | hsa-mir-34a-5p | 16 | 4.752406e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002669 | Osteosarcoma | A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. | 10 | 1.385437e-09 | 3 |
| HP | HP:0002863 | Myelodysplasia | Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia. | 13 | 4.254601e-08 | 3 |
| HP | HP:0004808 | Acute myeloid leukemia | A form of leukemia characterized by overproduction of an early myeloid cell. | 11 | 1.375573e-07 | 3 |
| HP | HP:0012133 | Erythroid hypoplasia | Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 8 | 4.803033e-07 | 3 |
| HP | HP:0012131 | Abnormal number of erythroid precursors | A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 9 | 1.605081e-06 | 3 |
| HP | HP:0011904 | Persistence of hemoglobin F | Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent. | 8 | 2.248507e-06 | 3 |
| HP | HP:0001895 | Normochromic anemia | Normochromic anemia | 8 | 3.530424e-06 | 3 |
| HP | HP:0031640 | Abnormal radial artery morphology | Any structural anomaly of the radial artery. | 7 | 4.861886e-06 | 3 |
| HP | HP:0030270 | Elevated red cell adenosine deaminase activity | Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine. | 7 | 4.861886e-06 | 3 |
| HP | HP:0020118 | Radial artery aplasia | Congenital absence of the radial artery. | 7 | 4.861886e-06 | 3 |
| HP | HP:4000209 | Abnormal erythrocyte adenosine deaminase activity | Activity of adenosine deaminase in red blood cells outside the limits of normal. | 7 | 6.514815e-06 | 3 |
| HP | HP:0005532 | Macrocytic dyserythropoietic anemia | Macrocytic dyserythropoietic anemia | 7 | 8.621925e-06 | 3 |
| HP | HP:0001894 | Thrombocytosis | Increased numbers of platelets in the peripheral blood. | 9 | 1.457116e-05 | 3 |
| HP | HP:0012410 | Pure red cell aplasia | A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction. | 7 | 1.460492e-05 | 3 |
| HP | HP:0002488 | Acute leukemia | A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). | 11 | 1.861388e-05 | 3 |
| HP | HP:0040276 | Adenocarcinoma of the colon | Adenocarcinoma of the colon | 7 | 4.647703e-05 | 3 |
| HP | HP:0001227 | Abnormality of the thenar eminence | An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb. | 7 | 4.647703e-05 | 3 |
| HP | HP:0000912 | Sprengel anomaly | A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other). | 8 | 5.342365e-05 | 3 |
| HP | HP:0006758 | Malignant genitourinary tract tumor | The presence of a malignant neoplasm of the genital system. | 7 | 5.726707e-05 | 3 |
| HP | HP:0011902 | Abnormal hemoglobin | Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes. | 9 | 5.857472e-05 | 3 |
| HP | HP:0100242 | Sarcoma | A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. | 12 | 6.923952e-05 | 3 |
| HP | HP:0010622 | Neoplasm of the skeletal system | A tumor (abnormal growth of tissue) of the skeleton. | 10 | 7.008294e-05 | 3 |
| HP | HP:0001896 | Reticulocytopenia | A reduced number of reticulocytes in the peripheral blood. | 7 | 7.010474e-05 | 3 |
| HP | HP:0001909 | Leukemia | A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. | 12 | 9.011717e-05 | 3 |
| HP | HP:0009777 | Absent thumb | Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues. | 8 | 9.554282e-05 | 3 |
| HP | HP:0004377 | Hematological neoplasm | Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). | 15 | 1.006985e-04 | 3 |
| HP | HP:0040275 | Adenocarcinoma of the large intestine | A malignant epithelial tumor with a glandular organization that originates in the large intestine. | 7 | 1.031828e-04 | 3 |
| HP | HP:0000185 | Cleft soft palate | Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency. | 8 | 1.256563e-04 | 3 |
| HP | HP:0009944 | Partial duplication of thumb phalanx | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 7 | 1.769796e-04 | 3 |
| HP | HP:0040273 | Adenocarcinoma of the intestines | A malignant epithelial tumor with a glandular organization that originates in the intestines. | 7 | 2.098216e-04 | 3 |
| HP | HP:0001874 | Abnormality of neutrophils | A neutrophil abnormality. | 14 | 2.189188e-04 | 3 |
| HP | HP:0009999 | Partial duplication of the phalanx of hand | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 7 | 2.476635e-04 | 3 |
| HP | HP:0001911 | Abnormal granulocyte morphology | Any structural abnormality or abnormal count of granulocytes. | 15 | 2.625626e-04 | 3 |
| HP | HP:0009380 | Finger aplasia | A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers). | 9 | 2.824699e-04 | 3 |
| HP | HP:0030272 | Abnormal erythrocyte enzyme concentration or activity | An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme. | 7 | 5.348447e-04 | 3 |
| HP | HP:0001972 | Macrocytic anemia | A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH). | 8 | 6.671179e-04 | 3 |
| HP | HP:0010974 | Abnormal myeloid leukocyte morphology | An abnormality of myeloid leukocytes. | 15 | 7.672048e-04 | 3 |
| HP | HP:0001875 | Decreased total neutrophil count | Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group. | 12 | 7.701661e-04 | 3 |
| HP | HP:0008772 | Aplasia/Hypoplasia of the external ear | The presence of aplasia or developmental hypoplasia of all or part of the external ear. | 12 | 7.701661e-04 | 3 |
| HP | HP:0005518 | Increased mean corpuscular volume | Larger than normal size of erythrocytes. | 7 | 8.145479e-04 | 3 |
| HP | HP:0008771 | Aplasia/Hypoplasia of the ear | The presence of aplasia or developmental hypoplasia of the ear. | 12 | 1.099459e-03 | 3 |
| HP | HP:0011792 | Neoplasm by histology | Neoplasm categorized according to type of histological abnormality. | 15 | 1.240336e-03 | 3 |
| HP | HP:0100273 | Neoplasm of the colon | Neoplasm of the colon | 8 | 1.486592e-03 | 3 |
| HP | HP:0032309 | Abnormal granulocyte count | Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group. | 13 | 1.873473e-03 | 3 |
| HP | HP:0011991 | Abnormal total neutrophil count | A deviation from the normal range of neutrophil cell counts in the circulation. | 12 | 1.963041e-03 | 3 |
| HP | HP:0000085 | Horseshoe kidney | A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline. | 10 | 2.175137e-03 | 3 |
| HP | HP:0009942 | Duplication of thumb phalanx | Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits. | 7 | 2.215142e-03 | 3 |
| HP | HP:0008551 | Microtia | Underdevelopment of the external ear. | 11 | 2.550991e-03 | 3 |
| HP | HP:0025065 | Abnormal mean corpuscular volume | A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters. | 7 | 2.778964e-03 | 3 |
| HP | HP:0009778 | Short thumb | Hypoplasia (congenital reduction in size) of the thumb. | 9 | 4.166345e-03 | 3 |
| HP | HP:0001790 | Nonimmune hydrops fetalis | A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens . | 7 | 4.271187e-03 | 3 |
| HP | HP:0011893 | Abnormal leukocyte count | Number of leukocytes per volume of blood beyond normal limits. | 17 | 4.940934e-03 | 3 |
| HP | HP:0001199 | Triphalangeal thumb | A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb. | 7 | 6.381086e-03 | 3 |
| HP | HP:0006749 | Malignant gastrointestinal tract tumors | Malignant gastrointestinal tract tumors | 7 | 1.017801e-02 | 3 |
| HP | HP:0001087 | Developmental glaucoma | Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma. | 7 | 1.017801e-02 | 3 |
| HP | HP:0002672 | Gastrointestinal carcinoma | Gastrointestinal carcinoma | 7 | 1.017801e-02 | 3 |
| HP | HP:0000519 | Developmental cataract | A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens. | 9 | 1.122651e-02 | 3 |
| HP | HP:0100736 | Abnormal soft palate morphology | An abnormality of the soft palate. | 12 | 1.248549e-02 | 3 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 11 | 1.610022e-02 | 3 |
| HP | HP:0009601 | Aplasia/Hypoplasia of the thumb | Hypoplastic/small or absent thumb. | 9 | 1.664215e-02 | 3 |
| HP | HP:0000294 | Low anterior hairline | Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella. | 9 | 1.757382e-02 | 3 |
| HP | HP:0100834 | Neoplasm of the large intestine | The presence of a neoplasm of the large intestine. | 8 | 1.929984e-02 | 3 |
| HP | HP:0004312 | Abnormal reticulocyte morphology | A reticulocyte abnormality. | 7 | 2.171585e-02 | 3 |
| HP | HP:0000980 | Pallor | Abnormally pale skin. | 9 | 2.293198e-02 | 3 |
| HP | HP:0001877 | Abnormal erythrocyte morphology | Any structural abnormality of erythrocytes (red-blood cells). | 19 | 2.339295e-02 | 3 |
| HP | HP:0100542 | Abnormal localization of kidney | An abnormal site of the kidney. | 11 | 2.405428e-02 | 3 |
| HP | HP:0001903 | Anemia | A reduction in erythrocytes volume or hemoglobin concentration. | 18 | 2.489896e-02 | 3 |
| HP | HP:0010987 | Abnormal cellular immune system morphology | An abnormality of the morphology or counts of the cells that make up the immune system. | 18 | 2.601402e-02 | 3 |
| HP | HP:0001881 | Abnormal leukocyte morphology | An abnormality of leukocytes. | 18 | 2.601402e-02 | 3 |
| HP | HP:0001882 | Decreased total leukocyte count | An abnormal decreased number of leukocytes in the blood. | 9 | 2.817041e-02 | 3 |
| HP | HP:0000465 | Webbed neck | Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline. | 8 | 3.359190e-02 | 3 |
| HP | HP:0011793 | Neoplasm by anatomical site | Neoplasm categorized according to the anatomical site of origin of the neoplasm. | 22 | 3.899519e-02 | 3 |
| HP | HP:0000218 | High palate | Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective). | 20 | 3.950934e-02 | 3 |
| HP | HP:0001421 | Abnormality of the musculature of the hand | Abnormality of the musculature of the hand | 8 | 4.234322e-02 | 3 |
| HP | HP:0032251 | Abnormal immune system morphology | Abnormal immune system morphology | 18 | 4.616989e-02 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 148 | 0.000003 | 3 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 137 | 0.000004 | 3 |
| TF | TF:M01660 | Factor: GABP-alpha; motif: CTTCCK | Factor: GABP-alpha; motif: CTTCCK | 123 | 0.000006 | 3 |
| TF | TF:M01078 | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | 96 | 0.000008 | 3 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 146 | 0.000012 | 3 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 145 | 0.000023 | 3 |
| TF | TF:M00426_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 80 | 0.000033 | 3 |
| TF | TF:M11527_1 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1 | 87 | 0.000037 | 3 |
| TF | TF:M00426 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 127 | 0.000038 | 3 |
| TF | TF:M09905 | Factor: SAP-1; motif: NNCCGGAAGTGN | Factor: SAP-1; motif: NNCCGGAAGTGN | 100 | 0.000057 | 3 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 125 | 0.000060 | 3 |
| TF | TF:M00425_1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | 75 | 0.000061 | 3 |
| TF | TF:M03967 | Factor: ELF3; motif: WACCCGGAAGTAN | Factor: ELF3; motif: WACCCGGAAGTAN | 94 | 0.000071 | 3 |
| TF | TF:M11430 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 119 | 0.000071 | 3 |
| TF | TF:M11527 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN | 88 | 0.000088 | 3 |
| TF | TF:M11882_1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | 123 | 0.000090 | 3 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 148 | 0.000091 | 3 |
| TF | TF:M00740 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | 116 | 0.000092 | 3 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 149 | 0.000107 | 3 |
| TF | TF:M01660_1 | Factor: GABP-alpha; motif: CTTCCK; match class: 1 | Factor: GABP-alpha; motif: CTTCCK; match class: 1 | 72 | 0.000116 | 3 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 133 | 0.000127 | 3 |
| TF | TF:M12600 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | 102 | 0.000132 | 3 |
| TF | TF:M04714 | Factor: Elf-1; motif: ACTTCCGGG | Factor: Elf-1; motif: ACTTCCGGG | 95 | 0.000157 | 3 |
| TF | TF:M11435_1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | 77 | 0.000208 | 3 |
| TF | TF:M12601 | Factor: ELF4; motif: NCCACTTCCGGNNNN | Factor: ELF4; motif: NCCACTTCCGGNNNN | 76 | 0.000271 | 3 |
| TF | TF:M00050 | Factor: E2F; motif: TTTSGCGC | Factor: E2F; motif: TTTSGCGC | 88 | 0.000341 | 3 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 149 | 0.000401 | 3 |
| TF | TF:M00333 | Factor: ZF5; motif: NRNGNGCGCGCWN | Factor: ZF5; motif: NRNGNGCGCGCWN | 144 | 0.000409 | 3 |
| TF | TF:M11419 | Factor: ER81; motif: NNCCGGAWGYN | Factor: ER81; motif: NNCCGGAWGYN | 79 | 0.000410 | 3 |
| TF | TF:M00425 | Factor: E2F; motif: TTTCGCGC | Factor: E2F; motif: TTTCGCGC | 119 | 0.000436 | 3 |
| TF | TF:M00025 | Factor: Elk-1; motif: NNNNCCGGAARTNN | Factor: Elk-1; motif: NNNNCCGGAARTNN | 111 | 0.000446 | 3 |
| TF | TF:M00940 | Factor: E2F-1; motif: NTTTCGCGCS | Factor: E2F-1; motif: NTTTCGCGCS | 94 | 0.000471 | 3 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 152 | 0.000503 | 3 |
| TF | TF:M02065_1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | 87 | 0.000521 | 3 |
| TF | TF:M04710 | Factor: CHD2; motif: TCTCGCGAG | Factor: CHD2; motif: TCTCGCGAG | 138 | 0.000534 | 3 |
| TF | TF:M03977_1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | 66 | 0.000590 | 3 |
| TF | TF:M03925_1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | 22 | 0.000592 | 3 |
| TF | TF:M04691_1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | 114 | 0.000720 | 3 |
| TF | TF:M13031 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 116 | 0.000733 | 3 |
| TF | TF:M07380_1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | 95 | 0.000806 | 3 |
| TF | TF:M11450 | Factor: Elf-1; motif: NANSCGGAAGTR | Factor: Elf-1; motif: NANSCGGAAGTR | 74 | 0.000884 | 3 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 111 | 0.000910 | 3 |
| TF | TF:M00025_1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | 63 | 0.000988 | 3 |
| TF | TF:M01820 | Factor: CREM; motif: TGACGTCASYN | Factor: CREM; motif: TGACGTCASYN | 80 | 0.001001 | 3 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 137 | 0.001032 | 3 |
| TF | TF:M04744_1 | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 | 67 | 0.001087 | 3 |
| TF | TF:M11447 | Factor: Elf-1; motif: NAMCCGGAAGTN | Factor: Elf-1; motif: NAMCCGGAAGTN | 92 | 0.001117 | 3 |
| TF | TF:M11434 | Factor: Elk-1; motif: NRSCGGAAGNN | Factor: Elk-1; motif: NRSCGGAAGNN | 96 | 0.001316 | 3 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 129 | 0.001334 | 3 |
| TF | TF:M02052 | Factor: EHF; motif: CSCGGAARTN | Factor: EHF; motif: CSCGGAARTN | 110 | 0.001424 | 3 |
| TF | TF:M11428 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 87 | 0.001453 | 3 |
| TF | TF:M04691 | Factor: Kaiso; motif: TCTCGCGAG | Factor: Kaiso; motif: TCTCGCGAG | 143 | 0.001501 | 3 |
| TF | TF:M03924 | Factor: YY1; motif: NNCGCCATTNN | Factor: YY1; motif: NNCGCCATTNN | 110 | 0.001563 | 3 |
| TF | TF:M09966_1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | 16 | 0.001621 | 3 |
| TF | TF:M02068 | Factor: etv3; motif: ACCGGAAGYN | Factor: etv3; motif: ACCGGAAGYN | 53 | 0.001629 | 3 |
| TF | TF:M08982 | Factor: YY1; motif: NAANATGGCGNNN | Factor: YY1; motif: NAANATGGCGNNN | 86 | 0.001651 | 3 |
| TF | TF:M13032 | Factor: ETV5; motif: ACCGGAAGTN | Factor: ETV5; motif: ACCGGAAGTN | 105 | 0.001742 | 3 |
| TF | TF:M07250 | Factor: E2F-1; motif: NNNSSCGCSAANN | Factor: E2F-1; motif: NNNSSCGCSAANN | 115 | 0.001756 | 3 |
| TF | TF:M09901 | Factor: nerf; motif: NNNCCGGAAGTGN | Factor: nerf; motif: NNNCCGGAAGTGN | 71 | 0.002017 | 3 |
| TF | TF:M04810 | Factor: USF2; motif: AAGTCACG | Factor: USF2; motif: AAGTCACG | 79 | 0.002091 | 3 |
| TF | TF:M11526_1 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1 | 83 | 0.002157 | 3 |
| TF | TF:M07415 | Factor: Elf-1; motif: AWCCCGGAAGTN | Factor: Elf-1; motif: AWCCCGGAAGTN | 93 | 0.002355 | 3 |
| TF | TF:M11526 | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN | Factor: E2F-3; motif: NTTTTGGCGCCAAAAN | 86 | 0.002496 | 3 |
| TF | TF:M02070 | Factor: TEL1; motif: CNCGGAANNN | Factor: TEL1; motif: CNCGGAANNN | 115 | 0.002549 | 3 |
| TF | TF:M02069 | Factor: Erm; motif: ACCGGAAGTN | Factor: Erm; motif: ACCGGAAGTN | 84 | 0.002613 | 3 |
| TF | TF:M11392_1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | 50 | 0.002661 | 3 |
| TF | TF:M11451 | Factor: Elf-1; motif: NANCCGGAAGTN | Factor: Elf-1; motif: NANCCGGAAGTN | 84 | 0.002849 | 3 |
| TF | TF:M01770 | Factor: XBP-1; motif: WNNGMCACGTC | Factor: XBP-1; motif: WNNGMCACGTC | 116 | 0.002918 | 3 |
| TF | TF:M11427 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 113 | 0.003070 | 3 |
| TF | TF:M11603_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 131 | 0.003240 | 3 |
| TF | TF:M02059_1 | Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 | Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 | 55 | 0.003503 | 3 |
| TF | TF:M00333_1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | 126 | 0.003800 | 3 |
| TF | TF:M03982 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 83 | 0.003830 | 3 |
| TF | TF:M11424 | Factor: Erm; motif: NNSCGGAWGYN | Factor: Erm; motif: NNSCGGAWGYN | 94 | 0.003987 | 3 |
| TF | TF:M00427 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 105 | 0.004115 | 3 |
| TF | TF:M02062 | Factor: Erg; motif: ACCGGAAGTN | Factor: Erg; motif: ACCGGAAGTN | 93 | 0.004164 | 3 |
| TF | TF:M02062_1 | Factor: Erg; motif: ACCGGAAGTN; match class: 1 | Factor: Erg; motif: ACCGGAAGTN; match class: 1 | 44 | 0.004299 | 3 |
| TF | TF:M08377_1 | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 | 67 | 0.004377 | 3 |
| TF | TF:M11400_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 59 | 0.004666 | 3 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 148 | 0.004761 | 3 |
| TF | TF:M08913 | Factor: FLI-1; motif: NAYTTCCGGT | Factor: FLI-1; motif: NAYTTCCGGT | 95 | 0.004934 | 3 |
| TF | TF:M01035 | Factor: YY1; motif: NYNKCCATNTT | Factor: YY1; motif: NYNKCCATNTT | 74 | 0.004966 | 3 |
| TF | TF:M02063 | Factor: c-ets-1; motif: ACCGGAWGTN | Factor: c-ets-1; motif: ACCGGAWGTN | 89 | 0.005122 | 3 |
| TF | TF:M13119 | Factor: ZBTB11; motif: RCTTCCGGNNSNNNN | Factor: ZBTB11; motif: RCTTCCGGNNSNNNN | 73 | 0.005188 | 3 |
| TF | TF:M08525_1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | 143 | 0.005592 | 3 |
| TF | TF:M03925 | Factor: YY2; motif: NCCGCCATNTY | Factor: YY2; motif: NCCGCCATNTY | 63 | 0.005724 | 3 |
| TF | TF:M00940_1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | 43 | 0.006167 | 3 |
| TF | TF:M11018 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | 151 | 0.007446 | 3 |
| TF | TF:M11529 | Factor: E2F-2; motif: GCGCGCGCNCS | Factor: E2F-2; motif: GCGCGCGCNCS | 148 | 0.007584 | 3 |
| TF | TF:M02066 | Factor: PEA3; motif: RCCGGAAGYN | Factor: PEA3; motif: RCCGGAAGYN | 84 | 0.008081 | 3 |
| TF | TF:M11400 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 107 | 0.008157 | 3 |
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 136 | 0.008338 | 3 |
| TF | TF:M09904 | Factor: Elk-1; motif: RCCGGAAGTGN | Factor: Elk-1; motif: RCCGGAAGTGN | 93 | 0.008446 | 3 |
| TF | TF:M11415 | Factor: GABP-alpha; motif: NRCCGGAAGTN | Factor: GABP-alpha; motif: NRCCGGAAGTN | 49 | 0.008898 | 3 |
| TF | TF:M03990 | Factor: GABPA; motif: ACCGGAAGTN | Factor: GABPA; motif: ACCGGAAGTN | 68 | 0.009216 | 3 |
| TF | TF:M00430 | Factor: E2F-1; motif: NTTSGCGG | Factor: E2F-1; motif: NTTSGCGG | 92 | 0.009521 | 3 |
| TF | TF:M02067 | Factor: ER71; motif: ACCGGAARYN | Factor: ER71; motif: ACCGGAARYN | 74 | 0.009709 | 3 |
| TF | TF:M08759 | Factor: c-Ets-2; motif: NCCGGAAGTG | Factor: c-Ets-2; motif: NCCGGAAGTG | 94 | 0.009909 | 3 |
| TF | TF:M11452 | Factor: Elf-1; motif: NANGCGGAAGTR | Factor: Elf-1; motif: NANGCGGAAGTR | 77 | 0.010133 | 3 |
| TF | TF:M03977 | Factor: ETS1; motif: ACCGGAARYN | Factor: ETS1; motif: ACCGGAARYN | 111 | 0.010317 | 3 |
| TF | TF:M00430_1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | 41 | 0.010656 | 3 |
| TF | TF:M04287 | Factor: BARHL2; motif: NNTAAAYGNN | Factor: BARHL2; motif: NNTAAAYGNN | 60 | 0.010763 | 3 |
| TF | TF:M07612 | Factor: PSF; motif: KWATCCGN | Factor: PSF; motif: KWATCCGN | 71 | 0.010920 | 3 |
| TF | TF:M11396_1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | 65 | 0.011240 | 3 |
| TF | TF:M03962_1 | Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT; match class: 1 | Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT; match class: 1 | 79 | 0.011285 | 3 |
| TF | TF:M12600_1 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN; match class: 1 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN; match class: 1 | 48 | 0.011312 | 3 |
| TF | TF:M11448 | Factor: Elf-1; motif: NANGCGGAAGTN | Factor: Elf-1; motif: NANGCGGAAGTN | 88 | 0.012497 | 3 |
| TF | TF:M11414 | Factor: GABP-alpha; motif: NACCGGAAGTN | Factor: GABP-alpha; motif: NACCGGAAGTN | 45 | 0.013483 | 3 |
| TF | TF:M04869_1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | 109 | 0.014113 | 3 |
| TF | TF:M10104 | Factor: YY1; motif: CAARATGGCGGC | Factor: YY1; motif: CAARATGGCGGC | 74 | 0.014224 | 3 |
| TF | TF:M10578 | Factor: Barhl-1; motif: NTAAACGN | Factor: Barhl-1; motif: NTAAACGN | 75 | 0.014410 | 3 |
| TF | TF:M08759_1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | 45 | 0.014484 | 3 |
| TF | TF:M11058_1 | Factor: Hey1; motif: NGCRCGYGYN; match class: 1 | Factor: Hey1; motif: NGCRCGYGYN; match class: 1 | 106 | 0.015187 | 3 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 62 | 0.015822 | 3 |
| TF | TF:M13031_1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | 64 | 0.016136 | 3 |
| TF | TF:M11434_1 | Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 | Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 | 45 | 0.016697 | 3 |
| TF | TF:M11531 | Factor: E2F-2; motif: GCGCGCGCGYW | Factor: E2F-2; motif: GCGCGCGCGYW | 130 | 0.016707 | 3 |
| TF | TF:M02059 | Factor: ELK-1; motif: ACCGGAAGTN | Factor: ELK-1; motif: ACCGGAAGTN | 102 | 0.017426 | 3 |
| TF | TF:M08913_1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | 46 | 0.017673 | 3 |
| TF | TF:M09607 | Factor: SAP-1; motif: ACCGGAAGTNN | Factor: SAP-1; motif: ACCGGAAGTNN | 62 | 0.018116 | 3 |
| TF | TF:M02052_1 | Factor: EHF; motif: CSCGGAARTN; match class: 1 | Factor: EHF; motif: CSCGGAARTN; match class: 1 | 56 | 0.018183 | 3 |
| TF | TF:M10785 | Factor: hoxa9; motif: RTCGTWANNN | Factor: hoxa9; motif: RTCGTWANNN | 70 | 0.018244 | 3 |
| TF | TF:M00431 | Factor: E2F-1; motif: TTTSGCGS | Factor: E2F-1; motif: TTTSGCGS | 85 | 0.018303 | 3 |
| TF | TF:M00024_1 | Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1 | Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1 | 42 | 0.018310 | 3 |
| TF | TF:M00737_1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | 45 | 0.018559 | 3 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 110 | 0.018813 | 3 |
| TF | TF:M03966 | Factor: ELF1; motif: AACCCGGAAGTR | Factor: ELF1; motif: AACCCGGAAGTR | 79 | 0.019148 | 3 |
| TF | TF:M03983 | Factor: ETV5; motif: NCCGGAWGYN | Factor: ETV5; motif: NCCGGAWGYN | 47 | 0.019197 | 3 |
| TF | TF:M10436 | Factor: YY1; motif: CAANATGGCGGC | Factor: YY1; motif: CAANATGGCGGC | 92 | 0.019859 | 3 |
| TF | TF:M07052 | Factor: NRF-1; motif: GCGCMTGCGCN | Factor: NRF-1; motif: GCGCMTGCGCN | 36 | 0.020412 | 3 |
| TF | TF:M11392 | Factor: Erg; motif: NACCGGAARYN | Factor: Erg; motif: NACCGGAARYN | 96 | 0.020812 | 3 |
| TF | TF:M02044 | Factor: YY1; motif: GCCGCCATTTTG | Factor: YY1; motif: GCCGCCATTTTG | 75 | 0.021287 | 3 |
| TF | TF:M01861 | Factor: ATF-1; motif: TNACGTCAN | Factor: ATF-1; motif: TNACGTCAN | 76 | 0.021697 | 3 |
| TF | TF:M09606 | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | 76 | 0.024133 | 3 |
| TF | TF:M00803_1 | Factor: E2F; motif: GGCGSG; match class: 1 | Factor: E2F; motif: GGCGSG; match class: 1 | 108 | 0.026063 | 3 |
| TF | TF:M11428_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 36 | 0.026642 | 3 |
| TF | TF:M11425_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 38 | 0.027061 | 3 |
| TF | TF:M01752_1 | Factor: ERG; motif: ACCGGAART; match class: 1 | Factor: ERG; motif: ACCGGAART; match class: 1 | 52 | 0.027202 | 3 |
| TF | TF:M11425 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 85 | 0.032535 | 3 |
| TF | TF:M04744 | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA | 106 | 0.032643 | 3 |
| TF | TF:M08875 | Factor: E2F; motif: NNTTTCGCGCN | Factor: E2F; motif: NNTTTCGCGCN | 75 | 0.038907 | 3 |
| TF | TF:M11530_1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | 130 | 0.039477 | 3 |
| TF | TF:M01752 | Factor: ERG; motif: ACCGGAART | Factor: ERG; motif: ACCGGAART | 101 | 0.040000 | 3 |
| TF | TF:M09887 | Factor: CREB1; motif: NRRTGACGTMA | Factor: CREB1; motif: NRRTGACGTMA | 72 | 0.041812 | 3 |
| TF | TF:M02064 | Factor: c-ets-2; motif: ACCGGAWRTN | Factor: c-ets-2; motif: ACCGGAWRTN | 112 | 0.042358 | 3 |
| TF | TF:M09641 | Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN | Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN | 47 | 0.042432 | 3 |
| TF | TF:M03962 | Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT | Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT | 113 | 0.042974 | 3 |
| TF | TF:M00539 | Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN | Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN | 78 | 0.048688 | 3 |
| TF | TF:M00539_1 | Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN; match class: 1 | Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN; match class: 1 | 78 | 0.048688 | 3 |
| TF | TF:M00615_1 | Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN; match class: 1 | Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN; match class: 1 | 78 | 0.048977 | 3 |
| TF | TF:M00615 | Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN | Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN | 78 | 0.048977 | 3 |
| TF | TF:M00738 | Factor: E2F-4:DP-1; motif: TTTSGCGC | Factor: E2F-4:DP-1; motif: TTTSGCGC | 104 | 0.049180 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 118 | 7.254609e-41 | 4 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 144 | 6.139165e-26 | 4 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 85 | 1.831878e-23 | 4 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 60 | 7.874801e-21 | 4 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 60 | 1.628150e-20 | 4 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 60 | 1.667696e-20 | 4 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 60 | 1.667696e-20 | 4 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 47 | 8.186849e-18 | 4 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 56 | 1.717326e-14 | 4 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 64 | 9.244273e-14 | 4 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 53 | 6.756479e-12 | 4 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 70 | 7.335098e-12 | 4 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 53 | 7.441418e-12 | 4 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 32 | 1.227039e-11 | 4 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 10 | 5.121610e-11 | 4 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 23 | 1.110793e-10 | 4 |
| GO:CC | GO:0005832 | chaperonin-containing T-complex | "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] | 6 | 6.538924e-09 | 4 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 46 | 1.097789e-08 | 4 |
| GO:CC | GO:0044297 | cell body | "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] | 22 | 1.508316e-08 | 4 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 34 | 4.540317e-08 | 4 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 29 | 4.782781e-08 | 4 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 29 | 5.698677e-08 | 4 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 26 | 9.611417e-08 | 4 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 25 | 1.060809e-07 | 4 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 138 | 1.092818e-07 | 4 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 82 | 1.107639e-07 | 4 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 82 | 1.116624e-07 | 4 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 36 | 1.124116e-07 | 4 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 82 | 1.365625e-07 | 4 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 82 | 1.365625e-07 | 4 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 82 | 1.365625e-07 | 4 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 37 | 1.772310e-07 | 4 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 67 | 1.813051e-07 | 4 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 44 | 2.455200e-07 | 4 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 16 | 2.480641e-07 | 4 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 16 | 3.099971e-07 | 4 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 16 | 3.239749e-07 | 4 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 28 | 4.389381e-07 | 4 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 146 | 4.431959e-07 | 4 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 142 | 5.641992e-07 | 4 |
| GO:CC | GO:0005952 | cAMP-dependent protein kinase complex | "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [PMID:18178622] | 5 | 5.994478e-07 | 4 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 42 | 6.301257e-07 | 4 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 89 | 1.519778e-06 | 4 |
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 36 | 1.755945e-06 | 4 |
| GO:CC | GO:0048471 | perinuclear region of cytoplasm | "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] | 22 | 2.447433e-06 | 4 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 59 | 3.004089e-06 | 4 |
| GO:CC | GO:0022624 | proteasome accessory complex | "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] | 6 | 5.071343e-06 | 4 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 137 | 5.406747e-06 | 4 |
| GO:CC | GO:0000502 | proteasome complex | "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome] | 8 | 6.227195e-06 | 4 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 102 | 7.425248e-06 | 4 |
| GO:CC | GO:0016234 | inclusion body | "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744] | 8 | 1.240191e-05 | 4 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 21 | 1.240235e-05 | 4 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 68 | 1.727107e-05 | 4 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 23 | 1.754080e-05 | 4 |
| GO:CC | GO:0000323 | lytic vacuole | "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] | 21 | 2.122008e-05 | 4 |
| GO:CC | GO:0005764 | lysosome | "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] | 21 | 2.122008e-05 | 4 |
| GO:CC | GO:0150034 | distal axon | "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] | 13 | 2.375521e-05 | 4 |
| GO:CC | GO:0031594 | neuromuscular junction | "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] | 8 | 2.569754e-05 | 4 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 9 | 3.042056e-05 | 4 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 9 | 3.042056e-05 | 4 |
| GO:CC | GO:0005773 | vacuole | "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] | 22 | 3.510278e-05 | 4 |
| GO:CC | GO:0002199 | zona pellucida receptor complex | "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] | 4 | 5.054999e-05 | 4 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 9 | 6.288234e-05 | 4 |
| GO:CC | GO:0043025 | neuronal cell body | "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] | 16 | 1.113751e-04 | 4 |
| GO:CC | GO:0005838 | proteasome regulatory particle | "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 5 | 1.166924e-04 | 4 |
| GO:CC | GO:0005929 | cilium | "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] | 20 | 1.447617e-04 | 4 |
| GO:CC | GO:1905369 | endopeptidase complex | "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 8 | 1.589434e-04 | 4 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 9 | 1.666255e-04 | 4 |
| GO:CC | GO:0030424 | axon | "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] | 18 | 1.990499e-04 | 4 |
| GO:CC | GO:0045121 | membrane raft | "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567] | 12 | 3.058830e-04 | 4 |
| GO:CC | GO:0098857 | membrane microdomain | "A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it." [PMID:20044567, PMID:26253820] | 12 | 3.284154e-04 | 4 |
| GO:CC | GO:0008540 | proteasome regulatory particle, base subcomplex | "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 4 | 3.499861e-04 | 4 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 9 | 3.738479e-04 | 4 |
| GO:CC | GO:0042582 | azurophil granule | "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule] | 9 | 4.167248e-04 | 4 |
| GO:CC | GO:0005766 | primary lysosome | "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] | 9 | 4.167248e-04 | 4 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 19 | 5.134865e-04 | 4 |
| GO:CC | GO:0005819 | spindle | "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] | 14 | 6.450741e-04 | 4 |
| GO:CC | GO:0030426 | growth cone | "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] | 9 | 8.135681e-04 | 4 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 12 | 9.234810e-04 | 4 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 125 | 1.020603e-03 | 4 |
| GO:CC | GO:0030427 | site of polarized growth | "Any part of a cell where non-isotropic growth takes place." [GOC:mah] | 9 | 1.036026e-03 | 4 |
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 7 | 1.042324e-03 | 4 |
| GO:CC | GO:1905368 | peptidase complex | "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 8 | 1.082900e-03 | 4 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 20 | 1.339256e-03 | 4 |
| GO:CC | GO:0005775 | vacuolar lumen | "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] | 9 | 1.434270e-03 | 4 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 9 | 1.716095e-03 | 4 |
| GO:CC | GO:0005774 | vacuolar membrane | "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] | 14 | 2.822457e-03 | 4 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 94 | 3.240726e-03 | 4 |
| GO:CC | GO:0031968 | organelle outer membrane | "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] | 10 | 3.953552e-03 | 4 |
| GO:CC | GO:0019867 | outer membrane | "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] | 10 | 4.227950e-03 | 4 |
| GO:CC | GO:0005765 | lysosomal membrane | "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] | 13 | 4.642579e-03 | 4 |
| GO:CC | GO:0098852 | lytic vacuole membrane | "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos] | 13 | 4.642579e-03 | 4 |
| GO:CC | GO:0097546 | ciliary base | "Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444] | 5 | 5.931102e-03 | 4 |
| GO:CC | GO:0036477 | somatodendritic compartment | "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL] | 18 | 7.958876e-03 | 4 |
| GO:CC | GO:0005741 | mitochondrial outer membrane | "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] | 9 | 9.228332e-03 | 4 |
| GO:CC | GO:0008021 | synaptic vesicle | "A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290] | 9 | 1.132438e-02 | 4 |
| GO:CC | GO:0098590 | plasma membrane region | "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] | 23 | 1.171941e-02 | 4 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 12 | 1.266622e-02 | 4 |
| GO:CC | GO:0031252 | cell leading edge | "The area of a motile cell closest to the direction of movement." [GOC:pg] | 12 | 1.483022e-02 | 4 |
| GO:CC | GO:0043005 | neuron projection | "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] | 23 | 1.527631e-02 | 4 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 12 | 1.585165e-02 | 4 |
| GO:CC | GO:1990565 | HSP90-CDC37 chaperone complex | "A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." [GOC:bhm, GOC:pad, GOC:PARL, PMID:21855797, PMID:22939624] | 2 | 1.662794e-02 | 4 |
| GO:CC | GO:0034515 | proteasome storage granule | "An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:krc, GOC:rb, PMID:18504300, PMID:30204036] | 2 | 1.662794e-02 | 4 |
| GO:CC | GO:0031588 | nucleotide-activated protein kinase complex | "A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae)." [GOC:bhm, GOC:mah, GOC:vw] | 3 | 1.761763e-02 | 4 |
| GO:CC | GO:0097136 | Bcl-2 family protein complex | "A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed." [GOC:so, PMID:14634621] | 3 | 1.761763e-02 | 4 |
| GO:CC | GO:0070382 | exocytic vesicle | "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] | 9 | 2.146295e-02 | 4 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 10 | 2.808660e-02 | 4 |
| GO:CC | GO:0008180 | COP9 signalosome | "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] | 4 | 3.279512e-02 | 4 |
| GO:CC | GO:0043204 | perikaryon | "The portion of the cell soma (neuronal cell body) that excludes the nucleus." [GOC:jl] | 7 | 3.338627e-02 | 4 |
| GO:CC | GO:0099522 | cytosolic region | "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos] | 4 | 3.670105e-02 | 4 |
| GO:CC | GO:0035253 | ciliary rootlet | "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867] | 3 | 3.828954e-02 | 4 |
| GO:CC | GO:0098793 | presynapse | "The part of a synapse that is part of the presynaptic cell." [GOC:dos] | 14 | 4.408246e-02 | 4 |
| GO:CC | GO:0016507 | mitochondrial fatty acid beta-oxidation multienzyme complex | "A multienzyme complex possessing three activities in two subunits (alpha and beta) that catalyzes three steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. The alpha subunit comprises the enoyl-CoA hydratase (ECH) and 3-hydroxyacyl-CoA dehydrogenase (HACD) activities, and the beta subunit contains the acetyl-CoA C-acyltransferase (KACT)/thiolase activity." [GOC:sjm, PMID:29915090] | 2 | 4.966157e-02 | 4 |
| GO:CC | GO:0036125 | fatty acid beta-oxidation multienzyme complex | "A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT)." [GOC:imk, PMID:12115060, PMID:16472743] | 2 | 4.966157e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 101 | 5.242979e-29 | 4 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 62 | 7.729083e-24 | 4 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 70 | 7.323707e-20 | 4 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 64 | 2.455187e-19 | 4 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 64 | 2.626196e-19 | 4 |
| GO:BP | GO:0006468 | protein phosphorylation | "The process of introducing a phosphate group on to a protein." [GOC:hb] | 47 | 3.554291e-19 | 4 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 71 | 5.139298e-19 | 4 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 48 | 1.008247e-18 | 4 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 41 | 1.180836e-16 | 4 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 67 | 1.205969e-16 | 4 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 55 | 1.570932e-16 | 4 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 54 | 8.172916e-16 | 4 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 40 | 1.202124e-15 | 4 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 71 | 1.481839e-15 | 4 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 52 | 5.975356e-15 | 4 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 15 | 6.109004e-15 | 4 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 39 | 6.234625e-15 | 4 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 70 | 7.808579e-15 | 4 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 38 | 1.887472e-14 | 4 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 74 | 2.223774e-14 | 4 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 70 | 4.182484e-14 | 4 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 52 | 5.955952e-14 | 4 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 59 | 1.085876e-13 | 4 |
| GO:BP | GO:1901698 | response to nitrogen compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 38 | 1.566493e-13 | 4 |
| GO:BP | GO:0051084 | 'de novo' post-translational protein folding | "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] | 12 | 2.239147e-13 | 4 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 56 | 2.738315e-13 | 4 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 23 | 3.684978e-13 | 4 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 72 | 7.496069e-13 | 4 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 62 | 9.102099e-13 | 4 |
| GO:BP | GO:0006458 | 'de novo' protein folding | "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] | 12 | 9.867809e-13 | 4 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 34 | 1.396381e-12 | 4 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 112 | 1.413081e-12 | 4 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 49 | 1.610624e-12 | 4 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 27 | 1.916038e-12 | 4 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 45 | 2.611188e-12 | 4 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 60 | 4.229554e-12 | 4 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 42 | 9.573344e-12 | 4 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 69 | 1.510569e-11 | 4 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 84 | 1.563123e-11 | 4 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 41 | 1.836033e-11 | 4 |
| GO:BP | GO:0009408 | response to heat | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] | 14 | 2.256871e-11 | 4 |
| GO:BP | GO:0061919 | process utilizing autophagic mechanism | "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] | 27 | 2.315835e-11 | 4 |
| GO:BP | GO:0006914 | autophagy | "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464] | 27 | 2.315835e-11 | 4 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 25 | 2.459309e-11 | 4 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 66 | 3.164783e-11 | 4 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 82 | 3.313960e-11 | 4 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 18 | 3.750596e-11 | 4 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 89 | 5.029660e-11 | 4 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 65 | 5.133931e-11 | 4 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 32 | 5.762007e-11 | 4 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 86 | 6.240539e-11 | 4 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 31 | 1.430303e-10 | 4 |
| GO:BP | GO:0042325 | regulation of phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] | 30 | 2.365158e-10 | 4 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 32 | 2.575962e-10 | 4 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 39 | 2.647738e-10 | 4 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 32 | 2.650119e-10 | 4 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 39 | 2.706873e-10 | 4 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] | 29 | 3.074616e-10 | 4 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 33 | 3.383143e-10 | 4 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 35 | 5.396918e-10 | 4 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 37 | 5.893479e-10 | 4 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 60 | 6.130444e-10 | 4 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 17 | 7.604241e-10 | 4 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 43 | 1.541486e-09 | 4 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 44 | 1.566159e-09 | 4 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 88 | 1.654496e-09 | 4 |
| GO:BP | GO:0034605 | cellular response to heat | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] | 11 | 1.731720e-09 | 4 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 88 | 2.058945e-09 | 4 |
| GO:BP | GO:0030162 | regulation of proteolysis | "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] | 21 | 2.081018e-09 | 4 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 92 | 2.295697e-09 | 4 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 33 | 2.340159e-09 | 4 |
| GO:BP | GO:0010506 | regulation of autophagy | "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] | 20 | 2.876728e-09 | 4 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] | 15 | 3.061912e-09 | 4 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 37 | 4.297025e-09 | 4 |
| GO:BP | GO:0051234 | establishment of localization | "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] | 74 | 4.433056e-09 | 4 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 94 | 4.735417e-09 | 4 |
| GO:BP | GO:0051086 | chaperone mediated protein folding independent of cofactor | "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] | 6 | 5.460961e-09 | 4 |
| GO:BP | GO:0007165 | signal transduction | "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] | 83 | 5.486794e-09 | 4 |
| GO:BP | GO:0009628 | response to abiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] | 33 | 6.001665e-09 | 4 |
| GO:BP | GO:0018209 | peptidyl-serine modification | "The modification of peptidyl-serine." [GOC:go_curators] | 15 | 8.071771e-09 | 4 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 40 | 8.116191e-09 | 4 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 87 | 8.374958e-09 | 4 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 99 | 1.511547e-08 | 4 |
| GO:BP | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 6 | 1.628737e-08 | 4 |
| GO:BP | GO:0009605 | response to external stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] | 48 | 2.101125e-08 | 4 |
| GO:BP | GO:0009266 | response to temperature stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] | 14 | 3.234510e-08 | 4 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 30 | 3.449333e-08 | 4 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] | 20 | 3.482582e-08 | 4 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 24 | 3.766211e-08 | 4 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] | 24 | 3.890575e-08 | 4 |
| GO:BP | GO:1904869 | regulation of protein localization to Cajal body | "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 6 | 4.048104e-08 | 4 |
| GO:BP | GO:1904871 | positive regulation of protein localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 6 | 4.048104e-08 | 4 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 78 | 4.767929e-08 | 4 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 24 | 4.875697e-08 | 4 |
| GO:BP | GO:0023056 | positive regulation of signaling | "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 40 | 6.406983e-08 | 4 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 28 | 7.230591e-08 | 4 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 99 | 8.345472e-08 | 4 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 46 | 8.539500e-08 | 4 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 26 | 8.872949e-08 | 4 |
| GO:BP | GO:0031400 | negative regulation of protein modification process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 18 | 9.958313e-08 | 4 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 79 | 1.054015e-07 | 4 |
| GO:BP | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705] | 10 | 1.119716e-07 | 4 |
| GO:BP | GO:1900182 | positive regulation of protein localization to nucleus | "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 11 | 1.260422e-07 | 4 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 24 | 1.319125e-07 | 4 |
| GO:BP | GO:0007017 | microtubule-based process | "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] | 29 | 1.330691e-07 | 4 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 42 | 1.348902e-07 | 4 |
| GO:BP | GO:0038034 | signal transduction in absence of ligand | "The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor." [GOC:al, GOC:ppm, GOC:pr, PMID:15044679] | 10 | 1.495345e-07 | 4 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 44 | 1.516930e-07 | 4 |
| GO:BP | GO:0035966 | response to topologically incorrect protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] | 13 | 1.633641e-07 | 4 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | "The alteration of an amino acid residue in a peptide." [GOC:mah] | 24 | 1.727398e-07 | 4 |
| GO:BP | GO:1903405 | protein localization to nuclear body | "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] | 6 | 1.760461e-07 | 4 |
| GO:BP | GO:1904867 | protein localization to Cajal body | "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 6 | 1.760461e-07 | 4 |
| GO:BP | GO:1904872 | regulation of telomerase RNA localization to Cajal body | "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 6 | 1.760461e-07 | 4 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 34 | 2.220622e-07 | 4 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 18 | 2.469066e-07 | 4 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 121 | 3.994680e-07 | 4 |
| GO:BP | GO:0032212 | positive regulation of telomere maintenance via telomerase | "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 7 | 4.200937e-07 | 4 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 37 | 4.390283e-07 | 4 |
| GO:BP | GO:0051050 | positive regulation of transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 26 | 4.476857e-07 | 4 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 21 | 4.745314e-07 | 4 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 23 | 5.075373e-07 | 4 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 20 | 5.513132e-07 | 4 |
| GO:BP | GO:1990173 | protein localization to nucleoplasm | "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] | 6 | 5.655002e-07 | 4 |
| GO:BP | GO:0043434 | response to peptide hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] | 19 | 5.786400e-07 | 4 |
| GO:BP | GO:0006810 | transport | "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] | 65 | 6.236382e-07 | 4 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 26 | 6.359083e-07 | 4 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 23 | 6.412189e-07 | 4 |
| GO:BP | GO:0051049 | regulation of transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 36 | 6.779336e-07 | 4 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 49 | 7.445867e-07 | 4 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] | 31 | 7.653923e-07 | 4 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 49 | 8.649458e-07 | 4 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 125 | 8.899409e-07 | 4 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 12 | 9.645881e-07 | 4 |
| GO:BP | GO:0010647 | positive regulation of cell communication | "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 38 | 9.755991e-07 | 4 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 48 | 9.778075e-07 | 4 |
| GO:BP | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 7 | 1.058888e-06 | 4 |
| GO:BP | GO:0042026 | protein refolding | "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] | 7 | 1.058888e-06 | 4 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 26 | 1.349074e-06 | 4 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 49 | 1.364617e-06 | 4 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 34 | 1.431844e-06 | 4 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 22 | 1.482335e-06 | 4 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] | 16 | 1.544805e-06 | 4 |
| GO:BP | GO:0032868 | response to insulin | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 15 | 1.566241e-06 | 4 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 29 | 1.651779e-06 | 4 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 22 | 1.713682e-06 | 4 |
| GO:BP | GO:0002682 | regulation of immune system process | "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] | 35 | 1.730906e-06 | 4 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] | 14 | 1.795242e-06 | 4 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 122 | 1.901335e-06 | 4 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 37 | 2.092049e-06 | 4 |
| GO:BP | GO:2001239 | regulation of extrinsic apoptotic signaling pathway in absence of ligand | "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis] | 8 | 2.258881e-06 | 4 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 31 | 2.305196e-06 | 4 |
| GO:BP | GO:1903050 | regulation of proteolysis involved in protein catabolic process | "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 14 | 2.509119e-06 | 4 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] | 19 | 2.727334e-06 | 4 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 20 | 3.336730e-06 | 4 |
| GO:BP | GO:0046785 | microtubule polymerization | "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] | 10 | 3.339282e-06 | 4 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 21 | 3.410813e-06 | 4 |
| GO:BP | GO:0031334 | positive regulation of protein-containing complex assembly | "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] | 13 | 3.484967e-06 | 4 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 12 | 3.678657e-06 | 4 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 60 | 4.186435e-06 | 4 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 66 | 4.507352e-06 | 4 |
| GO:BP | GO:0034097 | response to cytokine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] | 26 | 4.735865e-06 | 4 |
| GO:BP | GO:0090671 | telomerase RNA localization to Cajal body | "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 6 | 4.962155e-06 | 4 |
| GO:BP | GO:0090685 | RNA localization to nucleus | "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] | 6 | 4.962155e-06 | 4 |
| GO:BP | GO:0090672 | telomerase RNA localization | "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 6 | 4.962155e-06 | 4 |
| GO:BP | GO:0090670 | RNA localization to Cajal body | "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 6 | 4.962155e-06 | 4 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 20 | 5.138783e-06 | 4 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 20 | 5.138783e-06 | 4 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 9 | 5.139503e-06 | 4 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 33 | 5.390737e-06 | 4 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] | 19 | 5.848946e-06 | 4 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 21 | 6.407486e-06 | 4 |
| GO:BP | GO:1901652 | response to peptide | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] | 26 | 6.562895e-06 | 4 |
| GO:BP | GO:0031109 | microtubule polymerization or depolymerization | "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] | 11 | 7.162640e-06 | 4 |
| GO:BP | GO:0006986 | response to unfolded protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] | 11 | 8.340128e-06 | 4 |
| GO:BP | GO:0006952 | defense response | "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] | 37 | 8.632784e-06 | 4 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] | 13 | 9.325593e-06 | 4 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 45 | 9.448928e-06 | 4 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 16 | 1.090331e-05 | 4 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 17 | 1.113994e-05 | 4 |
| GO:BP | GO:0016236 | macroautophagy | "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339] | 16 | 1.133905e-05 | 4 |
| GO:BP | GO:1901099 | negative regulation of signal transduction in absence of ligand | "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand." [GOC:TermGenie] | 7 | 1.157054e-05 | 4 |
| GO:BP | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis] | 7 | 1.157054e-05 | 4 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 28 | 1.433830e-05 | 4 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 51 | 1.477224e-05 | 4 |
| GO:BP | GO:0009607 | response to biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] | 34 | 1.530058e-05 | 4 |
| GO:BP | GO:0070201 | regulation of establishment of protein localization | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] | 19 | 1.534251e-05 | 4 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 8 | 1.700676e-05 | 4 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 43 | 1.836830e-05 | 4 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 12 | 2.065175e-05 | 4 |
| GO:BP | GO:0051131 | chaperone-mediated protein complex assembly | "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai] | 6 | 2.390765e-05 | 4 |
| GO:BP | GO:0002376 | immune system process | "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] | 47 | 2.449296e-05 | 4 |
| GO:BP | GO:0009314 | response to radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] | 17 | 2.475933e-05 | 4 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 8 | 2.528560e-05 | 4 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 47 | 2.588423e-05 | 4 |
| GO:BP | GO:0051258 | protein polymerization | "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] | 14 | 2.683495e-05 | 4 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 72 | 2.793916e-05 | 4 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 13 | 2.805360e-05 | 4 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 12 | 2.918553e-05 | 4 |
| GO:BP | GO:0061136 | regulation of proteasomal protein catabolic process | "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] | 12 | 2.918553e-05 | 4 |
| GO:BP | GO:0051707 | response to other organism | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] | 33 | 2.925610e-05 | 4 |
| GO:BP | GO:0030099 | myeloid cell differentiation | "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149] | 17 | 3.024338e-05 | 4 |
| GO:BP | GO:0043207 | response to external biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] | 33 | 3.061986e-05 | 4 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 13 | 3.587336e-05 | 4 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 73 | 3.948598e-05 | 4 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 32 | 4.042479e-05 | 4 |
| GO:BP | GO:0001775 | cell activation | "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators] | 27 | 4.400514e-05 | 4 |
| GO:BP | GO:0032869 | cellular response to insulin stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 12 | 5.061577e-05 | 4 |
| GO:BP | GO:0080135 | regulation of cellular response to stress | "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 18 | 5.275216e-05 | 4 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 30 | 5.326497e-05 | 4 |
| GO:BP | GO:0030705 | cytoskeleton-dependent intracellular transport | "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] | 12 | 5.630219e-05 | 4 |
| GO:BP | GO:0032210 | regulation of telomere maintenance via telomerase | "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 7 | 5.703356e-05 | 4 |
| GO:BP | GO:0010563 | negative regulation of phosphorus metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 14 | 6.301818e-05 | 4 |
| GO:BP | GO:0045936 | negative regulation of phosphate metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 14 | 6.301818e-05 | 4 |
| GO:BP | GO:0043467 | regulation of generation of precursor metabolites and energy | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl] | 10 | 8.060884e-05 | 4 |
| GO:BP | GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 10 | 8.060884e-05 | 4 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 8 | 8.267691e-05 | 4 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] | 32 | 8.449550e-05 | 4 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 31 | 8.800087e-05 | 4 |
| GO:BP | GO:0010001 | glial cell differentiation | "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] | 13 | 9.077086e-05 | 4 |
| GO:BP | GO:0050776 | regulation of immune response | "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 24 | 9.537926e-05 | 4 |
| GO:BP | GO:0002764 | immune response-regulating signaling pathway | "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] | 18 | 9.608458e-05 | 4 |
| GO:BP | GO:0002684 | positive regulation of immune system process | "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] | 26 | 9.772165e-05 | 4 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 78 | 9.967368e-05 | 4 |
| GO:BP | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] | 9 | 1.027028e-04 | 4 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 9 | 1.027028e-04 | 4 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 37 | 1.033902e-04 | 4 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 14 | 1.102518e-04 | 4 |
| GO:BP | GO:2000573 | positive regulation of DNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 7 | 1.197695e-04 | 4 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 21 | 1.217531e-04 | 4 |
| GO:BP | GO:0051085 | chaperone cofactor-dependent protein refolding | "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb] | 6 | 1.255452e-04 | 4 |
| GO:BP | GO:0018107 | peptidyl-threonine phosphorylation | "The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038] | 8 | 1.263686e-04 | 4 |
| GO:BP | GO:0051656 | establishment of organelle localization | "The directed movement of an organelle to a specific location." [GOC:ai] | 17 | 1.343117e-04 | 4 |
| GO:BP | GO:0032787 | monocarboxylic acid metabolic process | "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] | 19 | 1.352360e-04 | 4 |
| GO:BP | GO:0016241 | regulation of macroautophagy | "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] | 11 | 1.425951e-04 | 4 |
| GO:BP | GO:0051640 | organelle localization | "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] | 19 | 1.495827e-04 | 4 |
| GO:BP | GO:0016477 | cell migration | "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] | 31 | 1.548807e-04 | 4 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 73 | 1.634093e-04 | 4 |
| GO:BP | GO:0002253 | activation of immune response | "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] | 18 | 1.656805e-04 | 4 |
| GO:BP | GO:0030097 | hemopoiesis | "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] | 24 | 1.671633e-04 | 4 |
| GO:BP | GO:1904951 | positive regulation of establishment of protein localization | "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] | 14 | 1.677121e-04 | 4 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 15 | 1.689721e-04 | 4 |
| GO:BP | GO:0045913 | positive regulation of carbohydrate metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] | 8 | 1.709970e-04 | 4 |
| GO:BP | GO:2001234 | negative regulation of apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 12 | 1.771595e-04 | 4 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 9 | 1.800619e-04 | 4 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] | 16 | 1.874124e-04 | 4 |
| GO:BP | GO:1904375 | regulation of protein localization to cell periphery | "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] | 10 | 1.914163e-04 | 4 |
| GO:BP | GO:1901800 | positive regulation of proteasomal protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] | 9 | 1.944738e-04 | 4 |
| GO:BP | GO:1904356 | regulation of telomere maintenance via telomere lengthening | "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 7 | 2.050211e-04 | 4 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 20 | 2.118415e-04 | 4 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 18 | 2.391795e-04 | 4 |
| GO:BP | GO:0043276 | anoikis | "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, PMID:37667281] | 6 | 2.703838e-04 | 4 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] | 25 | 2.859876e-04 | 4 |
| GO:BP | GO:2001236 | regulation of extrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 10 | 2.945763e-04 | 4 |
| GO:BP | GO:1905897 | regulation of response to endoplasmic reticulum stress | "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] | 8 | 3.019977e-04 | 4 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] | 43 | 3.260045e-04 | 4 |
| GO:BP | GO:0018210 | peptidyl-threonine modification | "The modification of peptidyl-threonine." [GOC:go_curators] | 8 | 3.306020e-04 | 4 |
| GO:BP | GO:0051402 | neuron apoptotic process | "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis] | 13 | 3.421360e-04 | 4 |
| GO:BP | GO:0030154 | cell differentiation | "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] | 59 | 3.510413e-04 | 4 |
| GO:BP | GO:0048869 | cellular developmental process | "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] | 59 | 3.539049e-04 | 4 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] | 45 | 4.880223e-04 | 4 |
| GO:BP | GO:0009185 | ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 9 | 4.961504e-04 | 4 |
| GO:BP | GO:0032273 | positive regulation of protein polymerization | "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 8 | 5.111564e-04 | 4 |
| GO:BP | GO:0010507 | negative regulation of autophagy | "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] | 8 | 5.559403e-04 | 4 |
| GO:BP | GO:0043470 | regulation of carbohydrate catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg] | 7 | 5.951037e-04 | 4 |
| GO:BP | GO:0009154 | purine ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 9 | 6.064460e-04 | 4 |
| GO:BP | GO:0007339 | binding of sperm to zona pellucida | "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] | 6 | 6.210132e-04 | 4 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 13 | 6.243836e-04 | 4 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 10 | 6.554968e-04 | 4 |
| GO:BP | GO:0006096 | glycolytic process | "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] | 8 | 6.556664e-04 | 4 |
| GO:BP | GO:0045321 | leukocyte activation | "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add] | 23 | 7.260707e-04 | 4 |
| GO:BP | GO:0046032 | ADP catabolic process | "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 8 | 7.703261e-04 | 4 |
| GO:BP | GO:0033135 | regulation of peptidyl-serine phosphorylation | "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] | 8 | 7.703261e-04 | 4 |
| GO:BP | GO:0016052 | carbohydrate catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 10 | 7.704941e-04 | 4 |
| GO:BP | GO:0045087 | innate immune response | "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] | 23 | 7.794564e-04 | 4 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 22 | 7.827781e-04 | 4 |
| GO:BP | GO:0009132 | nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 9 | 7.862165e-04 | 4 |
| GO:BP | GO:0034330 | cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] | 21 | 7.891132e-04 | 4 |
| GO:BP | GO:0002757 | immune response-activating signaling pathway | "The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add] | 16 | 8.106020e-04 | 4 |
| GO:BP | GO:0021782 | glial cell development | "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 9 | 8.377850e-04 | 4 |
| GO:BP | GO:0006109 | regulation of carbohydrate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] | 10 | 8.566435e-04 | 4 |
| GO:BP | GO:0007005 | mitochondrion organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] | 15 | 8.617761e-04 | 4 |
| GO:BP | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 8 | 9.017244e-04 | 4 |
| GO:BP | GO:0019364 | pyridine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] | 8 | 9.017244e-04 | 4 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 54 | 9.059973e-04 | 4 |
| GO:BP | GO:0045184 | establishment of protein localization | "The directed movement of a protein to a specific location." [GOC:bf] | 34 | 9.229470e-04 | 4 |
| GO:BP | GO:0050808 | synapse organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] | 17 | 9.242414e-04 | 4 |
| GO:BP | GO:0009416 | response to light stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] | 13 | 9.246888e-04 | 4 |
| GO:BP | GO:0045595 | regulation of cell differentiation | "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] | 30 | 9.365476e-04 | 4 |
| GO:BP | GO:0009261 | ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 9 | 9.497787e-04 | 4 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 14 | 9.627189e-04 | 4 |
| GO:BP | GO:0009181 | purine ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 9.743098e-04 | 4 |
| GO:BP | GO:0009137 | purine nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 9.743098e-04 | 4 |
| GO:BP | GO:0010970 | transport along microtubule | "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] | 10 | 1.001681e-03 | 4 |
| GO:BP | GO:0060284 | regulation of cell development | "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] | 21 | 1.014253e-03 | 4 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 116 | 1.038268e-03 | 4 |
| GO:BP | GO:0006195 | purine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 9 | 1.074519e-03 | 4 |
| GO:BP | GO:0044089 | positive regulation of cellular component biogenesis | "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 16 | 1.084824e-03 | 4 |
| GO:BP | GO:0072526 | pyridine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 8 | 1.134567e-03 | 4 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] | 28 | 1.165920e-03 | 4 |
| GO:BP | GO:0022411 | cellular component disassembly | "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] | 15 | 1.179956e-03 | 4 |
| GO:BP | GO:0009191 | ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 1.222799e-03 | 4 |
| GO:BP | GO:0046031 | ADP metabolic process | "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 8 | 1.316827e-03 | 4 |
| GO:BP | GO:0050804 | modulation of chemical synaptic transmission | "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai] | 16 | 1.334291e-03 | 4 |
| GO:BP | GO:0070841 | inclusion body assembly | "The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah] | 5 | 1.365068e-03 | 4 |
| GO:BP | GO:0099177 | regulation of trans-synaptic signaling | "Any process that modulates the frequency, rate or extent of trans-synaptic signaling." [GOC:dos] | 16 | 1.368873e-03 | 4 |
| GO:BP | GO:0022414 | reproductive process | "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] | 30 | 1.427617e-03 | 4 |
| GO:BP | GO:0006955 | immune response | "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add] | 35 | 1.451406e-03 | 4 |
| GO:BP | GO:0048870 | cell motility | "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] | 32 | 1.505718e-03 | 4 |
| GO:BP | GO:0009134 | nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 1.636854e-03 | 4 |
| GO:BP | GO:0010827 | regulation of D-glucose transmembrane transport | "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] | 7 | 1.781754e-03 | 4 |
| GO:BP | GO:0099536 | synaptic signaling | "Cell-cell signaling to, from or within a synapse." [GOC:dos] | 20 | 1.945591e-03 | 4 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 12 | 1.996331e-03 | 4 |
| GO:BP | GO:0046649 | lymphocyte activation | "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] | 20 | 2.221898e-03 | 4 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 25 | 2.226158e-03 | 4 |
| GO:BP | GO:0007399 | nervous system development | "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] | 40 | 2.284719e-03 | 4 |
| GO:BP | GO:0042063 | gliogenesis | "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid] | 13 | 2.421827e-03 | 4 |
| GO:BP | GO:0032271 | regulation of protein polymerization | "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 10 | 2.767987e-03 | 4 |
| GO:BP | GO:0072523 | purine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 9 | 2.844192e-03 | 4 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 113 | 2.913554e-03 | 4 |
| GO:BP | GO:0032501 | multicellular organismal process | "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] | 80 | 2.961388e-03 | 4 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] | 30 | 3.008138e-03 | 4 |
| GO:BP | GO:0009179 | purine ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 3.023774e-03 | 4 |
| GO:BP | GO:0009135 | purine nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 8 | 3.023774e-03 | 4 |
| GO:BP | GO:0034764 | positive regulation of transmembrane transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] | 10 | 3.168208e-03 | 4 |
| GO:BP | GO:0050778 | positive regulation of immune response | "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 19 | 3.253174e-03 | 4 |
| GO:BP | GO:0035036 | sperm-egg recognition | "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf] | 6 | 3.443260e-03 | 4 |
| GO:BP | GO:0044092 | negative regulation of molecular function | "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 16 | 3.544831e-03 | 4 |
| GO:BP | GO:0007249 | canonical NF-kappaB signal transduction | "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217] | 12 | 3.606630e-03 | 4 |
| GO:BP | GO:0000902 | cell morphogenesis | "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] | 22 | 3.623301e-03 | 4 |
| GO:BP | GO:0050807 | regulation of synapse organization | "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] | 12 | 3.729752e-03 | 4 |
| GO:BP | GO:0033121 | regulation of purine nucleotide catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] | 6 | 3.851168e-03 | 4 |
| GO:BP | GO:0030811 | regulation of nucleotide catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] | 6 | 3.851168e-03 | 4 |
| GO:BP | GO:0006110 | regulation of glycolytic process | "Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators] | 6 | 3.851168e-03 | 4 |
| GO:BP | GO:0140546 | defense response to symbiont | "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] | 23 | 3.951444e-03 | 4 |
| GO:BP | GO:1901136 | carbohydrate derivative catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] | 11 | 3.955503e-03 | 4 |
| GO:BP | GO:0009166 | nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] | 9 | 4.101207e-03 | 4 |
| GO:BP | GO:0051651 | maintenance of location in cell | "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai] | 10 | 4.122262e-03 | 4 |
| GO:BP | GO:0005975 | carbohydrate metabolic process | "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] | 16 | 4.263702e-03 | 4 |
| GO:BP | GO:0045732 | positive regulation of protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] | 10 | 4.303442e-03 | 4 |
| GO:BP | GO:0007268 | chemical synaptic transmission | "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435] | 19 | 4.328355e-03 | 4 |
| GO:BP | GO:0098916 | anterograde trans-synaptic signaling | "Cell-cell signaling from pre to post-synapse, across the synaptic cleft." [GOC:dos] | 19 | 4.328355e-03 | 4 |
| GO:BP | GO:0040007 | growth | "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] | 21 | 4.419230e-03 | 4 |
| GO:BP | GO:0042326 | negative regulation of phosphorylation | "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl] | 11 | 4.424739e-03 | 4 |
| GO:BP | GO:0009199 | ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 11 | 4.424739e-03 | 4 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] | 12 | 4.700720e-03 | 4 |
| GO:BP | GO:0099537 | trans-synaptic signaling | "Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos] | 19 | 4.842085e-03 | 4 |
| GO:BP | GO:0098542 | defense response to other organism | "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] | 25 | 4.868464e-03 | 4 |
| GO:BP | GO:0008286 | insulin receptor signaling pathway | "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] | 8 | 4.996021e-03 | 4 |
| GO:BP | GO:0006090 | pyruvate metabolic process | "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] | 8 | 4.996021e-03 | 4 |
| GO:BP | GO:0051098 | regulation of binding | "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] | 10 | 5.099281e-03 | 4 |
| GO:BP | GO:0031929 | TOR signaling | "The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295] | 9 | 5.268745e-03 | 4 |
| GO:BP | GO:0035295 | tube development | "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] | 23 | 5.286377e-03 | 4 |
| GO:BP | GO:0006954 | inflammatory response | "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732] | 20 | 5.308493e-03 | 4 |
| GO:BP | GO:0062012 | regulation of small molecule metabolic process | "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] | 12 | 5.350406e-03 | 4 |
| GO:BP | GO:0061684 | chaperone-mediated autophagy | "The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded." [GOC:pad, GOC:PARL, PMID:22743996, PMID:23434281] | 4 | 5.364283e-03 | 4 |
| GO:BP | GO:0050673 | epithelial cell proliferation | "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] | 14 | 5.536387e-03 | 4 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 125 | 5.561612e-03 | 4 |
| GO:BP | GO:0090666 | scaRNA localization to Cajal body | "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 3 | 5.951057e-03 | 4 |
| GO:BP | GO:0009566 | fertilization | "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] | 10 | 6.020091e-03 | 4 |
| GO:BP | GO:0072384 | organelle transport along microtubule | "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] | 7 | 6.138555e-03 | 4 |
| GO:BP | GO:0051235 | maintenance of location | "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] | 10 | 6.271679e-03 | 4 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 11 | 6.360380e-03 | 4 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 9 | 6.711542e-03 | 4 |
| GO:BP | GO:0099111 | microtubule-based transport | "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] | 10 | 6.802373e-03 | 4 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 7 | 7.113314e-03 | 4 |
| GO:BP | GO:0048167 | regulation of synaptic plasticity | "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, PMID:11891290] | 10 | 7.671426e-03 | 4 |
| GO:BP | GO:0044093 | positive regulation of molecular function | "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 20 | 7.742582e-03 | 4 |
| GO:BP | GO:0009141 | nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 11 | 7.847660e-03 | 4 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 46 | 7.950423e-03 | 4 |
| GO:BP | GO:0097305 | response to alcohol | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [GOC:pr, PMID:24014527] | 11 | 8.123051e-03 | 4 |
| GO:BP | GO:0019752 | carboxylic acid metabolic process | "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] | 20 | 8.143355e-03 | 4 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 9 | 8.481510e-03 | 4 |
| GO:BP | GO:0046326 | positive regulation of D-glucose import | "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai, GOC:dph, GOC:tb] | 5 | 9.096693e-03 | 4 |
| GO:BP | GO:0046034 | ATP metabolic process | "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] | 10 | 9.702266e-03 | 4 |
| GO:BP | GO:0000165 | MAPK cascade | "An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267] | 18 | 9.752700e-03 | 4 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 10 | 1.008246e-02 | 4 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 43 | 1.050066e-02 | 4 |
| GO:BP | GO:0048871 | multicellular organismal-level homeostasis | "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete] | 19 | 1.065181e-02 | 4 |
| GO:BP | GO:0040008 | regulation of growth | "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] | 16 | 1.088655e-02 | 4 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 29 | 1.109084e-02 | 4 |
| GO:BP | GO:0043436 | oxoacid metabolic process | "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] | 20 | 1.170731e-02 | 4 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] | 10 | 1.173528e-02 | 4 |
| GO:BP | GO:1901292 | nucleoside phosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie] | 9 | 1.214496e-02 | 4 |
| GO:BP | GO:0006082 | organic acid metabolic process | "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] | 20 | 1.289841e-02 | 4 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 64 | 1.333147e-02 | 4 |
| GO:BP | GO:1905898 | positive regulation of response to endoplasmic reticulum stress | "Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] | 5 | 1.365721e-02 | 4 |
| GO:BP | GO:0007267 | cell-cell signaling | "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah] | 25 | 1.406469e-02 | 4 |
| GO:BP | GO:0051094 | positive regulation of developmental process | "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 25 | 1.424635e-02 | 4 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] | 10 | 1.465293e-02 | 4 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 22 | 1.466881e-02 | 4 |
| GO:BP | GO:0008637 | apoptotic mitochondrial changes | "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis] | 7 | 1.507734e-02 | 4 |
| GO:BP | GO:0033044 | regulation of chromosome organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] | 10 | 1.575559e-02 | 4 |
| GO:BP | GO:0022607 | cellular component assembly | "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] | 57 | 1.577159e-02 | 4 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 20 | 1.586347e-02 | 4 |
| GO:BP | GO:0062013 | positive regulation of small molecule metabolic process | "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] | 8 | 1.594649e-02 | 4 |
| GO:BP | GO:0016049 | cell growth | "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] | 14 | 1.637581e-02 | 4 |
| GO:BP | GO:1905475 | regulation of protein localization to membrane | "Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] | 9 | 1.708742e-02 | 4 |
| GO:BP | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 7 | 1.711704e-02 | 4 |
| GO:BP | GO:0001933 | negative regulation of protein phosphorylation | "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] | 10 | 1.754382e-02 | 4 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 32 | 1.779724e-02 | 4 |
| GO:BP | GO:0046434 | organophosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai] | 10 | 1.817759e-02 | 4 |
| GO:BP | GO:0030335 | positive regulation of cell migration | "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] | 15 | 1.851273e-02 | 4 |
| GO:BP | GO:1903706 | regulation of hemopoiesis | "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] | 13 | 1.876595e-02 | 4 |
| GO:BP | GO:0042592 | homeostatic process | "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172] | 29 | 1.962750e-02 | 4 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] | 12 | 1.974490e-02 | 4 |
| GO:BP | GO:0006476 | protein deacetylation | "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] | 5 | 1.983614e-02 | 4 |
| GO:BP | GO:0072521 | purine-containing compound metabolic process | "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 15 | 2.013738e-02 | 4 |
| GO:BP | GO:1990778 | protein localization to cell periphery | "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] | 12 | 2.029318e-02 | 4 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 21 | 2.061073e-02 | 4 |
| GO:BP | GO:0002521 | leukocyte differentiation | "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] | 16 | 2.070299e-02 | 4 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 32 | 2.112084e-02 | 4 |
| GO:BP | GO:0001503 | ossification | "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] | 13 | 2.124326e-02 | 4 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] | 23 | 2.131536e-02 | 4 |
| GO:BP | GO:0035967 | cellular response to topologically incorrect protein | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] | 7 | 2.188628e-02 | 4 |
| GO:BP | GO:0071364 | cellular response to epidermal growth factor stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah] | 5 | 2.231863e-02 | 4 |
| GO:BP | GO:0009205 | purine ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 2.319375e-02 | 4 |
| GO:BP | GO:0070555 | response to interleukin-1 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:BHF, GOC:mah] | 7 | 2.323635e-02 | 4 |
| GO:BP | GO:0032103 | positive regulation of response to external stimulus | "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] | 16 | 2.324371e-02 | 4 |
| GO:BP | GO:0006816 | calcium ion transport | "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 13 | 2.342801e-02 | 4 |
| GO:BP | GO:0009259 | ribonucleotide metabolic process | "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 12 | 2.451881e-02 | 4 |
| GO:BP | GO:1903578 | regulation of ATP metabolic process | "Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] | 6 | 2.458828e-02 | 4 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 9 | 2.461181e-02 | 4 |
| GO:BP | GO:0010828 | positive regulation of D-glucose transmembrane transport | "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] | 5 | 2.503695e-02 | 4 |
| GO:BP | GO:0006753 | nucleoside phosphate metabolic process | "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] | 16 | 2.508845e-02 | 4 |
| GO:BP | GO:0035239 | tube morphogenesis | "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] | 19 | 2.599588e-02 | 4 |
| GO:BP | GO:0009988 | cell-cell recognition | "Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820] | 6 | 2.657145e-02 | 4 |
| GO:BP | GO:0051222 | positive regulation of protein transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 10 | 2.746920e-02 | 4 |
| GO:BP | GO:0051223 | regulation of protein transport | "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 13 | 2.839835e-02 | 4 |
| GO:BP | GO:0022008 | neurogenesis | "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] | 29 | 2.860416e-02 | 4 |
| GO:BP | GO:1904377 | positive regulation of protein localization to cell periphery | "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] | 6 | 2.868178e-02 | 4 |
| GO:BP | GO:0007051 | spindle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] | 9 | 2.876976e-02 | 4 |
| GO:BP | GO:0009144 | purine nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 2.936023e-02 | 4 |
| GO:BP | GO:0031347 | regulation of defense response | "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] | 18 | 3.025980e-02 | 4 |
| GO:BP | GO:0019693 | ribose phosphate metabolic process | "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 12 | 3.027336e-02 | 4 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 12 | 3.027336e-02 | 4 |
| GO:BP | GO:0030010 | establishment of cell polarity | "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] | 8 | 3.121565e-02 | 4 |
| GO:BP | GO:0141156 | cAMP/PKA signal transduction | "An intracellular signaling cassette that starts with production of cyclic AMP (cAMP) by adenylate cyclase (either transmembrane or soluble), which activates protein kinase A, and ends with activation of downstream effectors such as the transcription factor CREB that further transmit the signal within the cell." [PMID:23209152] | 3 | 3.280836e-02 | 4 |
| GO:BP | GO:2000147 | positive regulation of cell motility | "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] | 15 | 3.283021e-02 | 4 |
| GO:BP | GO:0046822 | regulation of nucleocytoplasmic transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] | 7 | 3.286486e-02 | 4 |
| GO:BP | GO:1904659 | D-glucose transmembrane transport | "The process in which D-glucose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050] | 7 | 3.286486e-02 | 4 |
| GO:BP | GO:0007006 | mitochondrial membrane organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 7 | 3.286486e-02 | 4 |
| GO:BP | GO:0090042 | tubulin deacetylation | "The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:BHF, GOC:dph, GOC:tb] | 4 | 3.329639e-02 | 4 |
| GO:BP | GO:0051090 | regulation of DNA-binding transcription factor activity | "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] | 11 | 3.337102e-02 | 4 |
| GO:BP | GO:0032386 | regulation of intracellular transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] | 10 | 3.572070e-02 | 4 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 8 | 3.572987e-02 | 4 |
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 8 | 3.572987e-02 | 4 |
| GO:BP | GO:0040012 | regulation of locomotion | "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] | 21 | 3.643548e-02 | 4 |
| GO:BP | GO:0061024 | membrane organization | "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] | 18 | 3.678968e-02 | 4 |
| GO:BP | GO:0070849 | response to epidermal growth factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:BHF, GOC:mah] | 5 | 3.858652e-02 | 4 |
| GO:BP | GO:0008645 | hexose transmembrane transport | "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule." [GOC:vw] | 7 | 3.879165e-02 | 4 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 58 | 3.947805e-02 | 4 |
| GO:BP | GO:0042391 | regulation of membrane potential | "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] | 13 | 4.118814e-02 | 4 |
| GO:BP | GO:0055086 | nucleobase-containing small molecule metabolic process | "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] | 16 | 4.134087e-02 | 4 |
| GO:BP | GO:0019637 | organophosphate metabolic process | "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] | 21 | 4.181063e-02 | 4 |
| GO:BP | GO:0048872 | homeostasis of number of cells | "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] | 11 | 4.421630e-02 | 4 |
| GO:BP | GO:0040017 | positive regulation of locomotion | "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] | 15 | 4.482517e-02 | 4 |
| GO:BP | GO:0015749 | monosaccharide transmembrane transport | "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GO_REF:0000069, GOC:TermGenie, GOC:vw] | 7 | 4.557330e-02 | 4 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 14 | 4.575574e-02 | 4 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 11 | 4.671756e-02 | 4 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 11 | 4.671756e-02 | 4 |
| GO:BP | GO:0030220 | platelet formation | "The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194] | 4 | 4.704475e-02 | 4 |
| GO:BP | GO:0035601 | protein deacylation | "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid." [GOC:se, PMID:12080046] | 5 | 4.720540e-02 | 4 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906] | 14 | 4.767482e-02 | 4 |
| GO:BP | GO:0072655 | establishment of protein localization to mitochondrion | "The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah] | 7 | 4.803969e-02 | 4 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 8 | 4.843300e-02 | 4 |
| GO:BP | GO:0015031 | protein transport | "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 25 | 4.854703e-02 | 4 |
| GO:BP | GO:0030030 | cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917] | 27 | 4.879248e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 61 | 5.325518e-25 | 4 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 58 | 1.240703e-23 | 4 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 67 | 9.687344e-23 | 4 |
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 15 | 1.083874e-21 | 4 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 68 | 1.409616e-21 | 4 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 55 | 1.418797e-21 | 4 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 64 | 2.469545e-21 | 4 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 64 | 3.807372e-21 | 4 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 67 | 5.717486e-21 | 4 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 63 | 5.725843e-21 | 4 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 68 | 3.131547e-20 | 4 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 61 | 1.371029e-19 | 4 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 66 | 6.426167e-19 | 4 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 67 | 2.715078e-18 | 4 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 107 | 2.797167e-18 | 4 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 25 | 3.018707e-16 | 4 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 25 | 1.197413e-15 | 4 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 15 | 1.268224e-15 | 4 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 35 | 3.986089e-15 | 4 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 64 | 8.095772e-15 | 4 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 38 | 2.304042e-14 | 4 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 36 | 4.605937e-14 | 4 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 29 | 7.179967e-14 | 4 |
| GO:MF | GO:0031072 | heat shock protein binding | "Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw] | 17 | 8.104228e-14 | 4 |
| GO:MF | GO:0106310 | protein serine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989] | 24 | 1.734159e-13 | 4 |
| GO:MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] | 39 | 7.660322e-13 | 4 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 147 | 1.409880e-12 | 4 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 29 | 4.964550e-11 | 4 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 14 | 8.719418e-11 | 4 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 30 | 1.079300e-10 | 4 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 26 | 1.770154e-09 | 4 |
| GO:MF | GO:0016740 | transferase activity | "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-] | 52 | 3.444176e-09 | 4 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 89 | 8.373843e-09 | 4 |
| GO:MF | GO:0048156 | tau protein binding | "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] | 9 | 1.766482e-08 | 4 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 86 | 3.751239e-08 | 4 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 17 | 3.782091e-07 | 4 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 22 | 1.011127e-06 | 4 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 42 | 2.826227e-06 | 4 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 17 | 8.193500e-06 | 4 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 19 | 2.897534e-05 | 4 |
| GO:MF | GO:0098772 | molecular function regulator activity | "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt] | 40 | 3.457956e-05 | 4 |
| GO:MF | GO:0051087 | protein-folding chaperone binding | "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443] | 10 | 4.509398e-05 | 4 |
| GO:MF | GO:0051787 | misfolded protein binding | "Binding to a misfolded protein." [GOC:ai] | 5 | 6.278933e-05 | 4 |
| GO:MF | GO:0004691 | cAMP-dependent protein kinase activity | "cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [PMID:32935175, PMID:35053423, PMID:35805104] | 5 | 8.842130e-05 | 4 |
| GO:MF | GO:0004690 | cyclic nucleotide-dependent protein kinase activity | "cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah] | 5 | 1.641797e-04 | 4 |
| GO:MF | GO:0016787 | hydrolase activity | "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] | 49 | 2.753171e-04 | 4 |
| GO:MF | GO:0042803 | protein homodimerization activity | "Binding to an identical protein to form a homodimer." [GOC:jl] | 20 | 3.558270e-04 | 4 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 25 | 5.860375e-04 | 4 |
| GO:MF | GO:0051879 | Hsp90 protein binding | "Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai] | 6 | 6.155808e-04 | 4 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 26 | 6.531789e-04 | 4 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 27 | 8.940332e-04 | 4 |
| GO:MF | GO:0051400 | BH domain binding | "Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] | 4 | 1.006012e-03 | 4 |
| GO:MF | GO:0097718 | disordered domain specific binding | "Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698] | 5 | 1.579522e-03 | 4 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 25 | 1.875232e-03 | 4 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 22 | 3.434083e-03 | 4 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 25 | 4.419703e-03 | 4 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 25 | 4.481020e-03 | 4 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 25 | 4.481020e-03 | 4 |
| GO:MF | GO:0051434 | BH3 domain binding | "Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] | 3 | 5.767186e-03 | 4 |
| GO:MF | GO:0030911 | TPR domain binding | "Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah] | 3 | 1.003766e-02 | 4 |
| GO:MF | GO:0030235 | nitric-oxide synthase regulator activity | "Binds to and modulates the activity of nitric oxide synthase." [GOC:mah] | 3 | 1.003766e-02 | 4 |
| GO:MF | GO:0004712 | protein serine/threonine/tyrosine kinase activity | "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah] | 5 | 1.177772e-02 | 4 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 149 | 1.399327e-02 | 4 |
| GO:MF | GO:0004679 | AMP-activated protein kinase activity | "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP." [GOC:mah] | 3 | 1.597290e-02 | 4 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 21 | 1.885369e-02 | 4 |
| GO:MF | GO:0023026 | MHC class II protein complex binding | "Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw] | 4 | 2.015079e-02 | 4 |
| GO:MF | GO:0019210 | kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a kinase." [GOC:mah] | 6 | 2.104867e-02 | 4 |
| GO:MF | GO:0016247 | channel regulator activity | "Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah] | 8 | 2.381494e-02 | 4 |
| GO:MF | GO:0035173 | histone kinase activity | "Catalysis of the transfer of a phosphate group to a histone." [GOC:bf] | 4 | 2.385118e-02 | 4 |
| GO:MF | GO:0030544 | Hsp70 protein binding | "Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732] | 5 | 2.486543e-02 | 4 |
| GO:MF | GO:0141108 | transporter regulator activity | "Binds to and modulates the activity of a transporter." [GOC:curators] | 8 | 2.595503e-02 | 4 |
| GO:MF | GO:0004709 | MAP kinase kinase kinase activity | "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] | 4 | 2.802581e-02 | 4 |
| GO:MF | GO:0140678 | molecular function inhibitor activity | "A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators] | 14 | 2.912951e-02 | 4 |
| GO:MF | GO:0019207 | kinase regulator activity | "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 10 | 3.223351e-02 | 4 |
| GO:MF | GO:0004517 | nitric-oxide synthase activity | "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, RHEA:19897] | 3 | 3.385650e-02 | 4 |
| GO:MF | GO:0004857 | enzyme inhibitor activity | "Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc] | 12 | 3.525176e-02 | 4 |
| GO:MF | GO:0015459 | potassium channel regulator activity | "Binds to and modulates the activity of a potassium channel." [GOC:dos, GOC:mah] | 5 | 3.962958e-02 | 4 |
| GO:MF | GO:0035403 | histone H3T6 kinase activity | "Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3." [GOC:bf] | 2 | 4.009420e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 22 | 5.537278e-17 | 4 |
| WP | WP:WP2359 | Parkin ubiquitin proteasomal system pathway | Parkin ubiquitin proteasomal system pathway | 18 | 9.277523e-16 | 4 |
| WP | WP:WP481 | Insulin signaling | Insulin signaling | 22 | 1.611844e-13 | 4 |
| WP | WP:WP3965 | Lipid metabolism pathway | Lipid metabolism pathway | 11 | 2.434429e-11 | 4 |
| WP | WP:WP382 | MAPK signaling | MAPK signaling | 23 | 1.444581e-10 | 4 |
| WP | WP:WP4566 | Translation inhibitors in chronically activated PDGFRA cells | Translation inhibitors in chronically activated PDGFRA cells | 12 | 3.009247e-10 | 4 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 23 | 5.055441e-10 | 4 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 23 | 7.529654e-10 | 4 |
| WP | WP:WP2795 | Cardiac hypertrophic response | Cardiac hypertrophic response | 11 | 4.946122e-08 | 4 |
| WP | WP:WP3915 | Angiopoietin like protein 8 regulatory pathway | Angiopoietin like protein 8 regulatory pathway | 15 | 1.378823e-07 | 4 |
| WP | WP:WP3872 | Apoptosis regulation by parathyroid hormone related protein | Apoptosis regulation by parathyroid hormone related protein | 8 | 2.106507e-07 | 4 |
| WP | WP:WP4806 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 12 | 5.466367e-07 | 4 |
| WP | WP:WP35 | G protein signaling | G protein signaling | 12 | 1.079608e-06 | 4 |
| WP | WP:WP437 | EGF EGFR signaling | EGF EGFR signaling | 15 | 1.710052e-06 | 4 |
| WP | WP:WP4223 | Ras signaling | Ras signaling | 16 | 1.738876e-06 | 4 |
| WP | WP:WP2380 | Brain derived neurotrophic factor BDNF signaling | Brain derived neurotrophic factor BDNF signaling | 14 | 2.145482e-06 | 4 |
| WP | WP:WP4172 | PI3K Akt signaling | PI3K Akt signaling | 21 | 3.002010e-06 | 4 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 11 | 5.119346e-06 | 4 |
| WP | WP:WP5441 | Artemisinin inhibition of uveal melanoma | Artemisinin inhibition of uveal melanoma | 4 | 9.059740e-06 | 4 |
| WP | WP:WP231 | TNF alpha signaling | TNF alpha signaling | 11 | 1.224528e-05 | 4 |
| WP | WP:WP195 | IL1 signaling | IL1 signaling | 9 | 1.461241e-05 | 4 |
| WP | WP:WP5372 | Involvement of secretase in neurodegenerative diseases | Involvement of secretase in neurodegenerative diseases | 6 | 1.958107e-05 | 4 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 22 | 4.688784e-05 | 4 |
| WP | WP:WP5531 | AKT signaling and ARTD family members | AKT signaling and ARTD family members | 7 | 9.757227e-05 | 4 |
| WP | WP:WP1403 | AMP activated protein kinase signaling | AMP activated protein kinase signaling | 9 | 1.001171e-04 | 4 |
| WP | WP:WP5094 | Orexin receptor pathway | Orexin receptor pathway | 10 | 1.121920e-04 | 4 |
| WP | WP:WP5293 | Acute myeloid leukemia | Acute myeloid leukemia | 9 | 1.139782e-04 | 4 |
| WP | WP:WP673 | ErbB signaling | ErbB signaling | 10 | 1.248435e-04 | 4 |
| WP | WP:WP4659 | Gastrin signaling | Gastrin signaling | 11 | 1.584156e-04 | 4 |
| WP | WP:WP3929 | Chemokine signaling | Chemokine signaling | 13 | 1.591676e-04 | 4 |
| WP | WP:WP2035 | Follicle stimulating hormone FSH signaling | Follicle stimulating hormone FSH signaling | 6 | 1.957949e-04 | 4 |
| WP | WP:WP5215 | Targeted agents in triple negative breast cancer | Targeted agents in triple negative breast cancer | 7 | 2.180438e-04 | 4 |
| WP | WP:WP4540 | Hippo signaling regulation | Hippo signaling regulation | 10 | 3.077156e-04 | 4 |
| WP | WP:WP3873 | RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis | RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis | 5 | 3.428056e-04 | 4 |
| WP | WP:WP3932 | Focal adhesion PI3K Akt mTOR signaling | Focal adhesion PI3K Akt mTOR signaling | 17 | 3.540791e-04 | 4 |
| WP | WP:WP2636 | Common pathways underlying drug addiction | Common pathways underlying drug addiction | 7 | 3.745336e-04 | 4 |
| WP | WP:WP4666 | Hepatitis B infection | Hepatitis B infection | 12 | 4.245531e-04 | 4 |
| WP | WP:WP289 | Myometrial relaxation and contraction pathways | Myometrial relaxation and contraction pathways | 12 | 4.874125e-04 | 4 |
| WP | WP:WP1544 | MicroRNAs in cardiomyocyte hypertrophy | MicroRNAs in cardiomyocyte hypertrophy | 10 | 5.325476e-04 | 4 |
| WP | WP:WP244 | Alpha 6 beta 4 signaling | Alpha 6 beta 4 signaling | 6 | 1.446407e-03 | 4 |
| WP | WP:WP2018 | RANKL RANK signaling | RANKL RANK signaling | 7 | 1.491870e-03 | 4 |
| WP | WP:WP4539 | Synaptic signaling associated with autism spectrum disorder | Synaptic signaling associated with autism spectrum disorder | 7 | 1.491870e-03 | 4 |
| WP | WP:WP5470 | Effect of omega 3 PUFA on Huntington 39 s disease pathways | Effect of omega 3 PUFA on Huntington 39 s disease pathways | 10 | 1.944079e-03 | 4 |
| WP | WP:WP4549 | Fragile X syndrome | Fragile X syndrome | 10 | 2.093250e-03 | 4 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 8 | 2.340364e-03 | 4 |
| WP | WP:WP536 | Calcium regulation in cardiac cells | Calcium regulation in cardiac cells | 11 | 2.348770e-03 | 4 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 21 | 2.489241e-03 | 4 |
| WP | WP:WP5294 | Sildenafil treatment | Sildenafil treatment | 5 | 2.768793e-03 | 4 |
| WP | WP:WP4949 | 16p11 2 proximal deletion syndrome | 16p11 2 proximal deletion syndrome | 8 | 2.857324e-03 | 4 |
| WP | WP:WP2374 | Oncostatin M signaling | Oncostatin M signaling | 7 | 3.220906e-03 | 4 |
| WP | WP:WP3879 | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression | 5 | 5.392933e-03 | 4 |
| WP | WP:WP2436 | Dopamine metabolism | Dopamine metabolism | 4 | 5.846753e-03 | 4 |
| WP | WP:WP183 | Proteasome degradation | Proteasome degradation | 7 | 6.351321e-03 | 4 |
| WP | WP:WP306 | Focal adhesion | Focal adhesion | 12 | 6.376770e-03 | 4 |
| WP | WP:WP4018 | Clear cell renal cell carcinoma pathways | Clear cell renal cell carcinoma pathways | 8 | 6.533301e-03 | 4 |
| WP | WP:WP4155 | Endometrial cancer | Endometrial cancer | 7 | 7.059239e-03 | 4 |
| WP | WP:WP5098 | T cell activation SARS CoV 2 | T cell activation SARS CoV 2 | 8 | 8.412282e-03 | 4 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 8 | 8.412282e-03 | 4 |
| WP | WP:WP2355 | Corticotropin releasing hormone signaling | Corticotropin releasing hormone signaling | 8 | 1.072278e-02 | 4 |
| WP | WP:WP3878 | ATM signaling in development and disease | ATM signaling in development and disease | 6 | 1.186028e-02 | 4 |
| WP | WP:WP1982 | Sterol regulatory element binding proteins SREBP signaling | Sterol regulatory element binding proteins SREBP signaling | 7 | 1.280153e-02 | 4 |
| WP | WP:WP2038 | Microtubule cytoskeleton regulation | Microtubule cytoskeleton regulation | 6 | 1.339364e-02 | 4 |
| WP | WP:WP4941 | GPR143 in melanocytes and retinal pigment epithelium cells | GPR143 in melanocytes and retinal pigment epithelium cells | 5 | 1.364157e-02 | 4 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 8 | 1.460546e-02 | 4 |
| WP | WP:WP2034 | Leptin signaling | Leptin signaling | 7 | 1.540246e-02 | 4 |
| WP | WP:WP5420 | ADHD and autism ASD pathways | ADHD and autism ASD pathways | 16 | 1.579255e-02 | 4 |
| WP | WP:WP4255 | Non small cell lung cancer | Non small cell lung cancer | 7 | 1.685608e-02 | 4 |
| WP | WP:WP3611 | Photodynamic therapy induced AP 1 survival signaling | Photodynamic therapy induced AP 1 survival signaling | 6 | 1.693442e-02 | 4 |
| WP | WP:WP3844 | PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer | PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer | 5 | 1.883072e-02 | 4 |
| WP | WP:WP69 | T cell receptor signaling | T cell receptor signaling | 7 | 2.190234e-02 | 4 |
| WP | WP:WP5344 | Cardiomyocyte signaling converging on titin | Cardiomyocyte signaling converging on titin | 5 | 2.193506e-02 | 4 |
| WP | WP:WP5490 | Inhibition of GNAQ regulated signaling in uveal melanoma | Inhibition of GNAQ regulated signaling in uveal melanoma | 5 | 2.193506e-02 | 4 |
| WP | WP:WP304 | Kit receptor signaling | Kit receptor signaling | 6 | 2.360471e-02 | 4 |
| WP | WP:WP3859 | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | 4 | 2.960801e-02 | 4 |
| WP | WP:WP4754 | IL18 signaling | IL18 signaling | 6 | 3.221009e-02 | 4 |
| WP | WP:WP4630 | Measles virus infection | Measles virus infection | 9 | 3.357630e-02 | 4 |
| WP | WP:WP1471 | Target of rapamycin signaling | Target of rapamycin signaling | 5 | 3.364060e-02 | 4 |
| WP | WP:WP5440 | EPAC1 and PKA reduction of retinal inflammation | EPAC1 and PKA reduction of retinal inflammation | 3 | 3.365022e-02 | 4 |
| WP | WP:WP3614 | Photodynamic therapy induced HIF 1 survival signaling | Photodynamic therapy induced HIF 1 survival signaling | 5 | 3.844475e-02 | 4 |
| WP | WP:WP2032 | Thyroid stimulating hormone TSH signaling | Thyroid stimulating hormone TSH signaling | 6 | 3.920699e-02 | 4 |
| WP | WP:WP4205 | MET in type 1 papillary renal cell carcinoma | MET in type 1 papillary renal cell carcinoma | 6 | 3.920699e-02 | 4 |
| WP | WP:WP5497 | Cyclin dependent kinase 4 6 inhibitors in breast cancer | Cyclin dependent kinase 4 6 inhibitors in breast cancer | 5 | 4.375520e-02 | 4 |
| WP | WP:WP2366 | Butyrate induced histone acetylation | Butyrate induced histone acetylation | 2 | 4.403537e-02 | 4 |
| WP | WP:WP5437 | GNAQ pathways in port wine stain | GNAQ pathways in port wine stain | 4 | 4.469350e-02 | 4 |
| WP | WP:WP4864 | Host pathogen interaction of human coronaviruses apoptosis | Host pathogen interaction of human coronaviruses apoptosis | 4 | 4.469350e-02 | 4 |
| WP | WP:WP1602 | Nicotine effect on dopaminergic neurons | Nicotine effect on dopaminergic neurons | 4 | 4.469350e-02 | 4 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 8 | 4.937324e-02 | 4 |
| WP | WP:WP4871 | Kisspeptin kisspeptin receptor system in the ovary | Kisspeptin kisspeptin receptor system in the ovary | 5 | 4.960663e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 70 | 2.749619e-16 | 4 |
| REAC | REAC:R-HSA-9006925 | Intracellular signaling by second messengers | Intracellular signaling by second messengers | 28 | 1.967570e-15 | 4 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 64 | 5.135088e-15 | 4 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 32 | 2.797323e-14 | 4 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 71 | 5.442835e-12 | 4 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 44 | 1.386171e-11 | 4 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 37 | 4.794712e-11 | 4 |
| REAC | REAC:R-HSA-1257604 | PIP3 activates AKT signaling | PIP3 activates AKT signaling | 22 | 7.444185e-11 | 4 |
| REAC | REAC:R-HSA-4420097 | VEGFA-VEGFR2 Pathway | VEGFA-VEGFR2 Pathway | 15 | 1.007541e-10 | 4 |
| REAC | REAC:R-HSA-194138 | Signaling by VEGF | Signaling by VEGF | 15 | 4.680293e-10 | 4 |
| REAC | REAC:R-HSA-1280218 | Adaptive Immune System | Adaptive Immune System | 36 | 7.851634e-10 | 4 |
| REAC | REAC:R-HSA-180024 | DARPP-32 events | DARPP-32 events | 9 | 1.025176e-09 | 4 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 42 | 1.030408e-09 | 4 |
| REAC | REAC:R-HSA-5610787 | Hedgehog 'off' state | Hedgehog 'off' state | 15 | 1.622949e-09 | 4 |
| REAC | REAC:R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | Signaling by Receptor Tyrosine Kinases | 28 | 3.654463e-09 | 4 |
| REAC | REAC:R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | Formation of tubulin folding intermediates by CCT/TriC | 9 | 3.803561e-09 | 4 |
| REAC | REAC:R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 10 | 5.714708e-09 | 4 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 18 | 6.025353e-09 | 4 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 18 | 7.151487e-09 | 4 |
| REAC | REAC:R-HSA-5358351 | Signaling by Hedgehog | Signaling by Hedgehog | 16 | 8.212497e-09 | 4 |
| REAC | REAC:R-HSA-111885 | Opioid Signalling | Opioid Signalling | 13 | 1.178971e-08 | 4 |
| REAC | REAC:R-HSA-390466 | Chaperonin-mediated protein folding | Chaperonin-mediated protein folding | 13 | 1.826812e-08 | 4 |
| REAC | REAC:R-HSA-449147 | Signaling by Interleukins | Signaling by Interleukins | 26 | 1.978758e-08 | 4 |
| REAC | REAC:R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | 11 | 2.048053e-08 | 4 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 15 | 2.463228e-08 | 4 |
| REAC | REAC:R-HSA-389357 | CD28 dependent PI3K/Akt signaling | CD28 dependent PI3K/Akt signaling | 8 | 3.588547e-08 | 4 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 14 | 4.122831e-08 | 4 |
| REAC | REAC:R-HSA-391251 | Protein folding | Protein folding | 13 | 4.181326e-08 | 4 |
| REAC | REAC:R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 9 | 4.376441e-08 | 4 |
| REAC | REAC:R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | The role of GTSE1 in G2/M progression after G2 checkpoint | 12 | 5.026211e-08 | 4 |
| REAC | REAC:R-HSA-109582 | Hemostasis | Hemostasis | 30 | 8.384352e-08 | 4 |
| REAC | REAC:R-HSA-6804757 | Regulation of TP53 Degradation | Regulation of TP53 Degradation | 9 | 1.036631e-07 | 4 |
| REAC | REAC:R-HSA-6806003 | Regulation of TP53 Expression and Degradation | Regulation of TP53 Expression and Degradation | 9 | 1.356162e-07 | 4 |
| REAC | REAC:R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | Regulation of mRNA stability by proteins that bind AU-rich elements | 12 | 1.398700e-07 | 4 |
| REAC | REAC:R-HSA-163685 | Integration of energy metabolism | Integration of energy metabolism | 13 | 1.469690e-07 | 4 |
| REAC | REAC:R-HSA-8948751 | Regulation of PTEN stability and activity | Regulation of PTEN stability and activity | 11 | 1.794170e-07 | 4 |
| REAC | REAC:R-HSA-390450 | Folding of actin by CCT/TriC | Folding of actin by CCT/TriC | 6 | 2.033727e-07 | 4 |
| REAC | REAC:R-HSA-5218920 | VEGFR2 mediated vascular permeability | VEGFR2 mediated vascular permeability | 8 | 2.370093e-07 | 4 |
| REAC | REAC:R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | AUF1 (hnRNP D0) binds and destabilizes mRNA | 10 | 2.463012e-07 | 4 |
| REAC | REAC:R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | Prefoldin mediated transfer of substrate to CCT/TriC | 8 | 3.285167e-07 | 4 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 26 | 3.485596e-07 | 4 |
| REAC | REAC:R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | GLI3 is processed to GLI3R by the proteasome | 10 | 7.305500e-07 | 4 |
| REAC | REAC:R-HSA-5610783 | Degradation of GLI2 by the proteasome | Degradation of GLI2 by the proteasome | 10 | 7.305500e-07 | 4 |
| REAC | REAC:R-HSA-5610780 | Degradation of GLI1 by the proteasome | Degradation of GLI1 by the proteasome | 10 | 7.305500e-07 | 4 |
| REAC | REAC:R-HSA-389356 | Co-stimulation by CD28 | Co-stimulation by CD28 | 8 | 8.092113e-07 | 4 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 26 | 9.076122e-07 | 4 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 31 | 1.012594e-06 | 4 |
| REAC | REAC:R-HSA-1227986 | Signaling by ERBB2 | Signaling by ERBB2 | 9 | 1.097354e-06 | 4 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 16 | 1.208988e-06 | 4 |
| REAC | REAC:R-HSA-163359 | Glucagon signaling in metabolic regulation | Glucagon signaling in metabolic regulation | 8 | 1.396061e-06 | 4 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 31 | 1.539387e-06 | 4 |
| REAC | REAC:R-HSA-5683057 | MAPK family signaling cascades | MAPK family signaling cascades | 19 | 1.636281e-06 | 4 |
| REAC | REAC:R-HSA-388841 | Regulation of T cell activation by CD28 family | Regulation of T cell activation by CD28 family | 10 | 2.239715e-06 | 4 |
| REAC | REAC:R-HSA-3371556 | Cellular response to heat stress | Cellular response to heat stress | 11 | 2.298570e-06 | 4 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 32 | 2.334572e-06 | 4 |
| REAC | REAC:R-HSA-9013418 | RHOBTB2 GTPase cycle | RHOBTB2 GTPase cycle | 7 | 2.394747e-06 | 4 |
| REAC | REAC:R-HSA-6807070 | PTEN Regulation | PTEN Regulation | 13 | 3.505890e-06 | 4 |
| REAC | REAC:R-HSA-76002 | Platelet activation, signaling and aggregation | Platelet activation, signaling and aggregation | 17 | 4.173349e-06 | 4 |
| REAC | REAC:R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | G beta:gamma signalling through PI3Kgamma | 7 | 4.603503e-06 | 4 |
| REAC | REAC:R-HSA-9009391 | Extra-nuclear estrogen signaling | Extra-nuclear estrogen signaling | 10 | 4.605297e-06 | 4 |
| REAC | REAC:R-HSA-9010642 | ROBO receptors bind AKAP5 | ROBO receptors bind AKAP5 | 5 | 4.783572e-06 | 4 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 11 | 7.382396e-06 | 4 |
| REAC | REAC:R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | Antiviral mechanism by IFN-stimulated genes | 13 | 7.553723e-06 | 4 |
| REAC | REAC:R-HSA-202424 | Downstream TCR signaling | Downstream TCR signaling | 11 | 8.232533e-06 | 4 |
| REAC | REAC:R-HSA-8863795 | Downregulation of ERBB2 signaling | Downregulation of ERBB2 signaling | 7 | 8.337628e-06 | 4 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 12 | 9.938547e-06 | 4 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 24 | 1.008589e-05 | 4 |
| REAC | REAC:R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | ADORA2B mediated anti-inflammatory cytokines production | 8 | 1.084860e-05 | 4 |
| REAC | REAC:R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 8 | 1.084860e-05 | 4 |
| REAC | REAC:R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | Fc epsilon receptor (FCERI) signaling | 14 | 1.249320e-05 | 4 |
| REAC | REAC:R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | Downstream signaling events of B Cell Receptor (BCR) | 10 | 1.304838e-05 | 4 |
| REAC | REAC:R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | Vasopressin regulates renal water homeostasis via Aquaporins | 8 | 1.319597e-05 | 4 |
| REAC | REAC:R-HSA-9634597 | GPER1 signaling | GPER1 signaling | 8 | 1.596832e-05 | 4 |
| REAC | REAC:R-HSA-9646399 | Aggrephagy | Aggrephagy | 8 | 1.596832e-05 | 4 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 10 | 1.661628e-05 | 4 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 10 | 2.101872e-05 | 4 |
| REAC | REAC:R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | Neurotransmitter receptors and postsynaptic signal transmission | 14 | 2.982930e-05 | 4 |
| REAC | REAC:R-HSA-397795 | G-protein beta:gamma signalling | G-protein beta:gamma signalling | 7 | 3.007586e-05 | 4 |
| REAC | REAC:R-HSA-1169091 | Activation of NF-kappaB in B cells | Activation of NF-kappaB in B cells | 9 | 3.450317e-05 | 4 |
| REAC | REAC:R-HSA-5687128 | MAPK6/MAPK4 signaling | MAPK6/MAPK4 signaling | 10 | 3.681318e-05 | 4 |
| REAC | REAC:R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | CREB1 phosphorylation through the activation of Adenylate Cyclase | 5 | 3.834589e-05 | 4 |
| REAC | REAC:R-HSA-3858494 | Beta-catenin independent WNT signaling | Beta-catenin independent WNT signaling | 12 | 4.896014e-05 | 4 |
| REAC | REAC:R-HSA-5684996 | MAPK1/MAPK3 signaling | MAPK1/MAPK3 signaling | 16 | 5.107184e-05 | 4 |
| REAC | REAC:R-HSA-9706574 | RHOBTB GTPase Cycle | RHOBTB GTPase Cycle | 7 | 5.833012e-05 | 4 |
| REAC | REAC:R-HSA-445717 | Aquaporin-mediated transport | Aquaporin-mediated transport | 8 | 6.260262e-05 | 4 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 13 | 6.427868e-05 | 4 |
| REAC | REAC:R-HSA-202403 | TCR signaling | TCR signaling | 11 | 6.834357e-05 | 4 |
| REAC | REAC:R-HSA-9604323 | Negative regulation of NOTCH4 signaling | Negative regulation of NOTCH4 signaling | 8 | 7.300045e-05 | 4 |
| REAC | REAC:R-HSA-446652 | Interleukin-1 family signaling | Interleukin-1 family signaling | 12 | 8.907648e-05 | 4 |
| REAC | REAC:R-HSA-438064 | Post NMDA receptor activation events | Post NMDA receptor activation events | 9 | 9.354118e-05 | 4 |
| REAC | REAC:R-HSA-9833482 | PKR-mediated signaling | PKR-mediated signaling | 9 | 9.354118e-05 | 4 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 14 | 1.122144e-04 | 4 |
| REAC | REAC:R-HSA-3371571 | HSF1-dependent transactivation | HSF1-dependent transactivation | 6 | 1.136744e-04 | 4 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 19 | 1.262761e-04 | 4 |
| REAC | REAC:R-HSA-422356 | Regulation of insulin secretion | Regulation of insulin secretion | 9 | 1.317999e-04 | 4 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 25 | 1.379610e-04 | 4 |
| REAC | REAC:R-HSA-2467813 | Separation of Sister Chromatids | Separation of Sister Chromatids | 13 | 1.383194e-04 | 4 |
| REAC | REAC:R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | Constitutive Signaling by AKT1 E17K in Cancer | 6 | 1.481178e-04 | 4 |
| REAC | REAC:R-HSA-112315 | Transmission across Chemical Synapses | Transmission across Chemical Synapses | 15 | 1.583107e-04 | 4 |
| REAC | REAC:R-HSA-3371568 | Attenuation phase | Attenuation phase | 5 | 1.614585e-04 | 4 |
| REAC | REAC:R-HSA-9663891 | Selective autophagy | Selective autophagy | 9 | 1.642759e-04 | 4 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 11 | 1.672326e-04 | 4 |
| REAC | REAC:R-HSA-9013694 | Signaling by NOTCH4 | Signaling by NOTCH4 | 9 | 1.829683e-04 | 4 |
| REAC | REAC:R-HSA-5673001 | RAF/MAP kinase cascade | RAF/MAP kinase cascade | 15 | 2.339187e-04 | 4 |
| REAC | REAC:R-HSA-5617833 | Cilium Assembly | Cilium Assembly | 13 | 2.812281e-04 | 4 |
| REAC | REAC:R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translation | Respiratory syncytial virus (RSV) genome replication, transcription and translation | 5 | 3.455920e-04 | 4 |
| REAC | REAC:R-HSA-9020702 | Interleukin-1 signaling | Interleukin-1 signaling | 10 | 3.531701e-04 | 4 |
| REAC | REAC:R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | Activation of NMDA receptors and postsynaptic events | 9 | 3.735715e-04 | 4 |
| REAC | REAC:R-HSA-164378 | PKA activation in glucagon signalling | PKA activation in glucagon signalling | 5 | 4.849253e-04 | 4 |
| REAC | REAC:R-HSA-2219528 | PI3K/AKT Signaling in Cancer | PI3K/AKT Signaling in Cancer | 9 | 4.972912e-04 | 4 |
| REAC | REAC:R-HSA-4086400 | PCP/CE pathway | PCP/CE pathway | 9 | 5.457220e-04 | 4 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 11 | 5.675147e-04 | 4 |
| REAC | REAC:R-HSA-9612973 | Autophagy | Autophagy | 11 | 6.066160e-04 | 4 |
| REAC | REAC:R-HSA-8939211 | ESR-mediated signaling | ESR-mediated signaling | 13 | 6.369285e-04 | 4 |
| REAC | REAC:R-HSA-163615 | PKA activation | PKA activation | 5 | 6.650407e-04 | 4 |
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 9 | 7.162473e-04 | 4 |
| REAC | REAC:R-HSA-8939902 | Regulation of RUNX2 expression and activity | Regulation of RUNX2 expression and activity | 8 | 7.323777e-04 | 4 |
| REAC | REAC:R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | Regulation of activated PAK-2p34 by proteasome mediated degradation | 7 | 7.470089e-04 | 4 |
| REAC | REAC:R-HSA-111931 | PKA-mediated phosphorylation of CREB | PKA-mediated phosphorylation of CREB | 5 | 8.939618e-04 | 4 |
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 24 | 8.975936e-04 | 4 |
| REAC | REAC:R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 7 | 9.809652e-04 | 4 |
| REAC | REAC:R-HSA-69610 | p53-Independent DNA Damage Response | p53-Independent DNA Damage Response | 7 | 9.809652e-04 | 4 |
| REAC | REAC:R-HSA-180534 | Vpu mediated degradation of CD4 | Vpu mediated degradation of CD4 | 7 | 9.809652e-04 | 4 |
| REAC | REAC:R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint | p53-Independent G1/S DNA damage checkpoint | 7 | 9.809652e-04 | 4 |
| REAC | REAC:R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | Autodegradation of the E3 ubiquitin ligase COP1 | 7 | 9.809652e-04 | 4 |
| REAC | REAC:R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 7 | 9.809652e-04 | 4 |
| REAC | REAC:R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | Ubiquitin-dependent degradation of Cyclin D | 7 | 9.809652e-04 | 4 |
| REAC | REAC:R-HSA-199418 | Negative regulation of the PI3K/AKT network | Negative regulation of the PI3K/AKT network | 9 | 1.013772e-03 | 4 |
| REAC | REAC:R-HSA-111997 | CaM pathway | CaM pathway | 6 | 1.030222e-03 | 4 |
| REAC | REAC:R-HSA-111933 | Calmodulin induced events | Calmodulin induced events | 6 | 1.030222e-03 | 4 |
| REAC | REAC:R-HSA-180585 | Vif-mediated degradation of APOBEC3G | Vif-mediated degradation of APOBEC3G | 7 | 1.119134e-03 | 4 |
| REAC | REAC:R-HSA-169911 | Regulation of Apoptosis | Regulation of Apoptosis | 7 | 1.119134e-03 | 4 |
| REAC | REAC:R-HSA-913531 | Interferon Signaling | Interferon Signaling | 14 | 1.124917e-03 | 4 |
| REAC | REAC:R-HSA-389513 | Co-inhibition by CTLA4 | Co-inhibition by CTLA4 | 5 | 1.180602e-03 | 4 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 13 | 1.224676e-03 | 4 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 13 | 1.285371e-03 | 4 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 24 | 1.297982e-03 | 4 |
| REAC | REAC:R-HSA-8941858 | Regulation of RUNX3 expression and activity | Regulation of RUNX3 expression and activity | 7 | 1.444512e-03 | 4 |
| REAC | REAC:R-HSA-4641257 | Degradation of AXIN | Degradation of AXIN | 7 | 1.444512e-03 | 4 |
| REAC | REAC:R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | SCF-beta-TrCP mediated degradation of Emi1 | 7 | 1.444512e-03 | 4 |
| REAC | REAC:R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 7 | 1.444512e-03 | 4 |
| REAC | REAC:R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | Signaling by the B Cell Receptor (BCR) | 11 | 1.462733e-03 | 4 |
| REAC | REAC:R-HSA-111996 | Ca-dependent events | Ca-dependent events | 6 | 1.463224e-03 | 4 |
| REAC | REAC:R-HSA-109704 | PI3K Cascade | PI3K Cascade | 6 | 1.463224e-03 | 4 |
| REAC | REAC:R-HSA-9607240 | FLT3 Signaling | FLT3 Signaling | 6 | 1.463224e-03 | 4 |
| REAC | REAC:R-HSA-5362768 | Hh mutants are degraded by ERAD | Hh mutants are degraded by ERAD | 7 | 1.634650e-03 | 4 |
| REAC | REAC:R-HSA-1632852 | Macroautophagy | Macroautophagy | 10 | 1.679684e-03 | 4 |
| REAC | REAC:R-HSA-4641258 | Degradation of DVL | Degradation of DVL | 7 | 1.845192e-03 | 4 |
| REAC | REAC:R-HSA-69541 | Stabilization of p53 | Stabilization of p53 | 7 | 1.845192e-03 | 4 |
| REAC | REAC:R-HSA-2871837 | FCERI mediated NF-kB activation | FCERI mediated NF-kB activation | 10 | 1.919096e-03 | 4 |
| REAC | REAC:R-HSA-9613829 | Chaperone Mediated Autophagy | Chaperone Mediated Autophagy | 5 | 1.967303e-03 | 4 |
| REAC | REAC:R-HSA-8853659 | RET signaling | RET signaling | 6 | 2.033834e-03 | 4 |
| REAC | REAC:R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | Association of TriC/CCT with target proteins during biosynthesis | 6 | 2.033834e-03 | 4 |
| REAC | REAC:R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | NIK-->noncanonical NF-kB signaling | 7 | 2.334389e-03 | 4 |
| REAC | REAC:R-HSA-5387390 | Hh mutants abrogate ligand secretion | Hh mutants abrogate ligand secretion | 7 | 2.334389e-03 | 4 |
| REAC | REAC:R-HSA-112399 | IRS-mediated signalling | IRS-mediated signalling | 6 | 2.380306e-03 | 4 |
| REAC | REAC:R-HSA-195253 | Degradation of beta-catenin by the destruction complex | Degradation of beta-catenin by the destruction complex | 8 | 2.409417e-03 | 4 |
| REAC | REAC:R-HSA-211163 | AKT-mediated inactivation of FOXO1A | AKT-mediated inactivation of FOXO1A | 3 | 2.594920e-03 | 4 |
| REAC | REAC:R-HSA-165158 | Activation of AKT2 | Activation of AKT2 | 3 | 2.594920e-03 | 4 |
| REAC | REAC:R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | Dectin-1 mediated noncanonical NF-kB signaling | 7 | 2.616748e-03 | 4 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 7 | 2.616748e-03 | 4 |
| REAC | REAC:R-HSA-1489509 | DAG and IP3 signaling | DAG and IP3 signaling | 6 | 2.773198e-03 | 4 |
| REAC | REAC:R-HSA-5632684 | Hedgehog 'on' state | Hedgehog 'on' state | 8 | 2.881784e-03 | 4 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 8 | 2.881784e-03 | 4 |
| REAC | REAC:R-HSA-5678895 | Defective CFTR causes cystic fibrosis | Defective CFTR causes cystic fibrosis | 7 | 2.926925e-03 | 4 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 12 | 2.926927e-03 | 4 |
| REAC | REAC:R-HSA-195721 | Signaling by WNT | Signaling by WNT | 15 | 3.025402e-03 | 4 |
| REAC | REAC:R-HSA-163560 | Triglyceride catabolism | Triglyceride catabolism | 5 | 3.115174e-03 | 4 |
| REAC | REAC:R-HSA-9006931 | Signaling by Nuclear Receptors | Signaling by Nuclear Receptors | 14 | 3.346523e-03 | 4 |
| REAC | REAC:R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 4 | 3.499852e-03 | 4 |
| REAC | REAC:R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | Downregulation of ERBB2:ERBB3 signaling | 4 | 3.499852e-03 | 4 |
| REAC | REAC:R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 4 | 3.499852e-03 | 4 |
| REAC | REAC:R-HSA-1852241 | Organelle biogenesis and maintenance | Organelle biogenesis and maintenance | 14 | 3.620327e-03 | 4 |
| REAC | REAC:R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | Autodegradation of Cdh1 by Cdh1:APC/C | 7 | 4.046146e-03 | 4 |
| REAC | REAC:R-HSA-4608870 | Asymmetric localization of PCP proteins | Asymmetric localization of PCP proteins | 7 | 4.046146e-03 | 4 |
| REAC | REAC:R-HSA-2428924 | IGF1R signaling cascade | IGF1R signaling cascade | 6 | 4.277747e-03 | 4 |
| REAC | REAC:R-HSA-2428928 | IRS-related events triggered by IGF1R | IRS-related events triggered by IGF1R | 6 | 4.277747e-03 | 4 |
| REAC | REAC:R-HSA-1236974 | ER-Phagosome pathway | ER-Phagosome pathway | 8 | 4.416492e-03 | 4 |
| REAC | REAC:R-HSA-5358346 | Hedgehog ligand biogenesis | Hedgehog ligand biogenesis | 7 | 4.489957e-03 | 4 |
| REAC | REAC:R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 6 | 4.905165e-03 | 4 |
| REAC | REAC:R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 7 | 4.973359e-03 | 4 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 7 | 4.973359e-03 | 4 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 7 | 4.973359e-03 | 4 |
| REAC | REAC:R-HSA-388396 | GPCR downstream signalling | GPCR downstream signalling | 21 | 5.233369e-03 | 4 |
| REAC | REAC:R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | Regulation of HSF1-mediated heat shock response | 7 | 5.499073e-03 | 4 |
| REAC | REAC:R-HSA-5658442 | Regulation of RAS by GAPs | Regulation of RAS by GAPs | 7 | 5.499073e-03 | 4 |
| REAC | REAC:R-HSA-74751 | Insulin receptor signalling cascade | Insulin receptor signalling cascade | 6 | 5.604949e-03 | 4 |
| REAC | REAC:R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | APC/C:Cdc20 mediated degradation of Securin | 7 | 6.069949e-03 | 4 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 7 | 6.069949e-03 | 4 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 8 | 6.094847e-03 | 4 |
| REAC | REAC:R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | PKA-mediated phosphorylation of key metabolic factors | 3 | 6.430718e-03 | 4 |
| REAC | REAC:R-HSA-418555 | G alpha (s) signalling events | G alpha (s) signalling events | 10 | 6.471645e-03 | 4 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 8 | 6.589431e-03 | 4 |
| REAC | REAC:R-HSA-157118 | Signaling by NOTCH | Signaling by NOTCH | 12 | 7.658115e-03 | 4 |
| REAC | REAC:R-HSA-418594 | G alpha (i) signalling events | G alpha (i) signalling events | 14 | 7.662956e-03 | 4 |
| REAC | REAC:R-HSA-5633007 | Regulation of TP53 Activity | Regulation of TP53 Activity | 10 | 8.068555e-03 | 4 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 7 | 8.084079e-03 | 4 |
| REAC | REAC:R-HSA-112043 | PLC beta mediated events | PLC beta mediated events | 6 | 8.201427e-03 | 4 |
| REAC | REAC:R-HSA-9705683 | SARS-CoV-2-host interactions | SARS-CoV-2-host interactions | 11 | 8.871490e-03 | 4 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 10 | 8.986668e-03 | 4 |
| REAC | REAC:R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | Cross-presentation of soluble exogenous antigens (endosomes) | 6 | 9.255281e-03 | 4 |
| REAC | REAC:R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8 | 9.598776e-03 | 4 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 7 | 9.711036e-03 | 4 |
| REAC | REAC:R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 7 | 9.711036e-03 | 4 |
| REAC | REAC:R-HSA-195258 | RHO GTPase Effectors | RHO GTPase Effectors | 14 | 9.816992e-03 | 4 |
| REAC | REAC:R-HSA-9664433 | Leishmania parasite growth and survival | Leishmania parasite growth and survival | 9 | 1.005210e-02 | 4 |
| REAC | REAC:R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | Anti-inflammatory response favouring Leishmania parasite infection | 9 | 1.005210e-02 | 4 |
| REAC | REAC:R-HSA-975155 | MyD88 dependent cascade initiated on endosome | MyD88 dependent cascade initiated on endosome | 8 | 1.032136e-02 | 4 |
| REAC | REAC:R-HSA-168898 | Toll-like Receptor Cascades | Toll-like Receptor Cascades | 10 | 1.053162e-02 | 4 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 7 | 1.062042e-02 | 4 |
| REAC | REAC:R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 7 | 1.062042e-02 | 4 |
| REAC | REAC:R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8 | 1.108899e-02 | 4 |
| REAC | REAC:R-HSA-1234174 | Cellular response to hypoxia | Cellular response to hypoxia | 7 | 1.159881e-02 | 4 |
| REAC | REAC:R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | Regulation of ornithine decarboxylase (ODC) | 6 | 1.168992e-02 | 4 |
| REAC | REAC:R-HSA-5218921 | VEGFR2 mediated cell proliferation | VEGFR2 mediated cell proliferation | 4 | 1.240066e-02 | 4 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 7 | 1.265022e-02 | 4 |
| REAC | REAC:R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | Factors involved in megakaryocyte development and platelet production | 10 | 1.294211e-02 | 4 |
| REAC | REAC:R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | Toll Like Receptor 9 (TLR9) Cascade | 8 | 1.368470e-02 | 4 |
| REAC | REAC:R-HSA-1236975 | Antigen processing-Cross presentation | Antigen processing-Cross presentation | 8 | 1.368470e-02 | 4 |
| REAC | REAC:R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 7 | 1.377879e-02 | 4 |
| REAC | REAC:R-HSA-112040 | G-protein mediated events | G-protein mediated events | 6 | 1.461452e-02 | 4 |
| REAC | REAC:R-HSA-5619084 | ABC transporter disorders | ABC transporter disorders | 7 | 1.498885e-02 | 4 |
| REAC | REAC:R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4 | 1.606704e-02 | 4 |
| REAC | REAC:R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | Signaling by Ligand-Responsive EGFR Variants in Cancer | 4 | 1.606704e-02 | 4 |
| REAC | REAC:R-HSA-9824272 | Somitogenesis | Somitogenesis | 6 | 1.809905e-02 | 4 |
| REAC | REAC:R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 6 | 1.809905e-02 | 4 |
| REAC | REAC:R-HSA-6798695 | Neutrophil degranulation | Neutrophil degranulation | 17 | 1.893546e-02 | 4 |
| REAC | REAC:R-HSA-9658195 | Leishmania infection | Leishmania infection | 11 | 1.901661e-02 | 4 |
| REAC | REAC:R-HSA-9824443 | Parasitic Infection Pathways | Parasitic Infection Pathways | 11 | 1.901661e-02 | 4 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 7 | 1.915352e-02 | 4 |
| REAC | REAC:R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | Toll Like Receptor 4 (TLR4) Cascade | 9 | 2.010016e-02 | 4 |
| REAC | REAC:R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | Toll Like Receptor TLR6:TLR2 Cascade | 8 | 2.041642e-02 | 4 |
| REAC | REAC:R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8 | 2.041642e-02 | 4 |
| REAC | REAC:R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7 | 2.073594e-02 | 4 |
| REAC | REAC:R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | RUNX2 regulates genes involved in cell migration | 3 | 2.211691e-02 | 4 |
| REAC | REAC:R-HSA-8963896 | HDL assembly | HDL assembly | 3 | 2.211691e-02 | 4 |
| REAC | REAC:R-HSA-163765 | ChREBP activates metabolic gene expression | ChREBP activates metabolic gene expression | 3 | 2.211691e-02 | 4 |
| REAC | REAC:R-HSA-351202 | Metabolism of polyamines | Metabolism of polyamines | 6 | 2.454346e-02 | 4 |
| REAC | REAC:R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | Toll Like Receptor 2 (TLR2) Cascade | 8 | 2.470080e-02 | 4 |
| REAC | REAC:R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | Toll Like Receptor TLR1:TLR2 Cascade | 8 | 2.470080e-02 | 4 |
| REAC | REAC:R-HSA-372790 | Signaling by GPCR | Signaling by GPCR | 21 | 2.692612e-02 | 4 |
| REAC | REAC:R-HSA-112316 | Neuronal System | Neuronal System | 15 | 3.076814e-02 | 4 |
| REAC | REAC:R-HSA-8979227 | Triglyceride metabolism | Triglyceride metabolism | 5 | 3.218783e-02 | 4 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 7 | 3.263960e-02 | 4 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 7 | 3.263960e-02 | 4 |
| REAC | REAC:R-HSA-9700206 | Signaling by ALK in cancer | Signaling by ALK in cancer | 7 | 3.507897e-02 | 4 |
| REAC | REAC:R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | Signaling by ALK fusions and activated point mutants | 7 | 3.507897e-02 | 4 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 7 | 4.330345e-02 | 4 |
| REAC | REAC:R-HSA-165159 | MTOR signalling | MTOR signalling | 5 | 4.670272e-02 | 4 |
| REAC | REAC:R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | 4 | 4.715421e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04910 | Insulin signaling pathway | Insulin signaling pathway | 18 | 1.620627e-11 | 4 |
| KEGG | KEGG:04010 | MAPK signaling pathway | MAPK signaling pathway | 24 | 7.843957e-11 | 4 |
| KEGG | KEGG:04728 | Dopaminergic synapse | Dopaminergic synapse | 16 | 1.262496e-09 | 4 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | Lipid and atherosclerosis | 19 | 3.953228e-09 | 4 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 20 | 7.136078e-09 | 4 |
| KEGG | KEGG:04931 | Insulin resistance | Insulin resistance | 14 | 1.171556e-08 | 4 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 24 | 1.255748e-08 | 4 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 20 | 2.192129e-08 | 4 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 26 | 3.698730e-08 | 4 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | Relaxin signaling pathway | 14 | 1.297202e-07 | 4 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 17 | 4.902088e-07 | 4 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | Longevity regulating pathway - multiple species | 10 | 5.857194e-07 | 4 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | EGFR tyrosine kinase inhibitor resistance | 11 | 5.909367e-07 | 4 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 21 | 6.667224e-07 | 4 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 16 | 1.033965e-06 | 4 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | Human immunodeficiency virus 1 infection | 16 | 1.460411e-06 | 4 |
| KEGG | KEGG:05020 | Prion disease | Prion disease | 18 | 1.470297e-06 | 4 |
| KEGG | KEGG:04540 | Gap junction | Gap junction | 11 | 1.893634e-06 | 4 |
| KEGG | KEGG:04725 | Cholinergic synapse | Cholinergic synapse | 12 | 2.701576e-06 | 4 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 10 | 3.081899e-06 | 4 |
| KEGG | KEGG:04140 | Autophagy - animal | Autophagy - animal | 14 | 3.221461e-06 | 4 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | Spinocerebellar ataxia | 13 | 3.833966e-06 | 4 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | Neurotrophin signaling pathway | 12 | 4.412233e-06 | 4 |
| KEGG | KEGG:04014 | Ras signaling pathway | Ras signaling pathway | 16 | 7.151361e-06 | 4 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | Chemokine signaling pathway | 14 | 1.900534e-05 | 4 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 12 | 1.979830e-05 | 4 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | Acute myeloid leukemia | 9 | 2.095233e-05 | 4 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | Estrogen signaling pathway | 12 | 2.147425e-05 | 4 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | PD-L1 expression and PD-1 checkpoint pathway in cancer | 10 | 2.419304e-05 | 4 |
| KEGG | KEGG:05032 | Morphine addiction | Morphine addiction | 10 | 2.419304e-05 | 4 |
| KEGG | KEGG:04211 | Longevity regulating pathway | Longevity regulating pathway | 10 | 2.419304e-05 | 4 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 18 | 2.971271e-05 | 4 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | Growth hormone synthesis, secretion and action | 11 | 4.810858e-05 | 4 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | Thyroid hormone signaling pathway | 11 | 5.233403e-05 | 4 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | Chemical carcinogenesis - receptor activation | 14 | 6.869256e-05 | 4 |
| KEGG | KEGG:04150 | mTOR signaling pathway | mTOR signaling pathway | 12 | 8.891608e-05 | 4 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 12 | 1.424851e-04 | 4 |
| KEGG | KEGG:04012 | ErbB signaling pathway | ErbB signaling pathway | 9 | 1.493853e-04 | 4 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 13 | 1.580902e-04 | 4 |
| KEGG | KEGG:04371 | Apelin signaling pathway | Apelin signaling pathway | 11 | 1.951649e-04 | 4 |
| KEGG | KEGG:05162 | Measles | Measles | 11 | 1.951649e-04 | 4 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 13 | 1.988436e-04 | 4 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 12 | 2.093846e-04 | 4 |
| KEGG | KEGG:04612 | Antigen processing and presentation | Antigen processing and presentation | 8 | 3.207574e-04 | 4 |
| KEGG | KEGG:04912 | GnRH signaling pathway | GnRH signaling pathway | 9 | 3.532189e-04 | 4 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | T cell receptor signaling pathway | 10 | 3.626375e-04 | 4 |
| KEGG | KEGG:04152 | AMPK signaling pathway | AMPK signaling pathway | 10 | 3.912311e-04 | 4 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | Sphingolipid signaling pathway | 10 | 3.912311e-04 | 4 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 9 | 4.220315e-04 | 4 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 21 | 4.829947e-04 | 4 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 9 | 5.020573e-04 | 4 |
| KEGG | KEGG:04611 | Platelet activation | Platelet activation | 10 | 5.261015e-04 | 4 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | Choline metabolism in cancer | 9 | 5.467304e-04 | 4 |
| KEGG | KEGG:05214 | Glioma | Glioma | 8 | 6.057092e-04 | 4 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 8 | 6.695365e-04 | 4 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 8 | 6.695365e-04 | 4 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | Progesterone-mediated oocyte maturation | 9 | 7.612235e-04 | 4 |
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 7 | 1.034459e-03 | 4 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | Regulation of lipolysis in adipocytes | 7 | 1.034459e-03 | 4 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | B cell receptor signaling pathway | 8 | 1.080767e-03 | 4 |
| KEGG | KEGG:04370 | VEGF signaling pathway | VEGF signaling pathway | 7 | 1.160924e-03 | 4 |
| KEGG | KEGG:05145 | Toxoplasmosis | Toxoplasmosis | 9 | 1.216297e-03 | 4 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | HIF-1 signaling pathway | 9 | 1.311147e-03 | 4 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | Fluid shear stress and atherosclerosis | 10 | 1.364168e-03 | 4 |
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | Diabetic cardiomyopathy | 12 | 1.403165e-03 | 4 |
| KEGG | KEGG:04510 | Focal adhesion | Focal adhesion | 12 | 1.403165e-03 | 4 |
| KEGG | KEGG:04530 | Tight junction | Tight junction | 11 | 1.466160e-03 | 4 |
| KEGG | KEGG:04726 | Serotonergic synapse | Serotonergic synapse | 9 | 1.634495e-03 | 4 |
| KEGG | KEGG:04929 | GnRH secretion | GnRH secretion | 7 | 2.001331e-03 | 4 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 13 | 2.122738e-03 | 4 |
| KEGG | KEGG:04727 | GABAergic synapse | GABAergic synapse | 8 | 2.172616e-03 | 4 |
| KEGG | KEGG:04664 | Fc epsilon RI signaling pathway | Fc epsilon RI signaling pathway | 7 | 2.711162e-03 | 4 |
| KEGG | KEGG:04720 | Long-term potentiation | Long-term potentiation | 7 | 2.711162e-03 | 4 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 8 | 2.770208e-03 | 4 |
| KEGG | KEGG:03050 | Proteasome | Proteasome | 6 | 2.896395e-03 | 4 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 12 | 3.004832e-03 | 4 |
| KEGG | KEGG:05031 | Amphetamine addiction | Amphetamine addiction | 7 | 3.290672e-03 | 4 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | Adrenergic signaling in cardiomyocytes | 10 | 3.350522e-03 | 4 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | Central carbon metabolism in cancer | 7 | 3.616506e-03 | 4 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 10 | 3.746125e-03 | 4 |
| KEGG | KEGG:04713 | Circadian entrainment | Circadian entrainment | 8 | 4.070376e-03 | 4 |
| KEGG | KEGG:01524 | Platinum drug resistance | Platinum drug resistance | 7 | 4.347927e-03 | 4 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | Inflammatory mediator regulation of TRP channels | 8 | 4.383589e-03 | 4 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | AGE-RAGE signaling pathway in diabetic complications | 8 | 5.070609e-03 | 4 |
| KEGG | KEGG:05142 | Chagas disease | Chagas disease | 8 | 5.446421e-03 | 4 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 10 | 6.713752e-03 | 4 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 11 | 6.903890e-03 | 4 |
| KEGG | KEGG:04620 | Toll-like receptor signaling pathway | Toll-like receptor signaling pathway | 8 | 7.691740e-03 | 4 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | Glucagon signaling pathway | 8 | 8.222195e-03 | 4 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 15 | 8.493561e-03 | 4 |
| KEGG | KEGG:04960 | Aldosterone-regulated sodium reabsorption | Aldosterone-regulated sodium reabsorption | 5 | 1.162045e-02 | 4 |
| KEGG | KEGG:04724 | Glutamatergic synapse | Glutamatergic synapse | 8 | 1.366187e-02 | 4 |
| KEGG | KEGG:05034 | Alcoholism | Alcoholism | 10 | 1.805977e-02 | 4 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 13 | 1.917621e-02 | 4 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | Oxytocin signaling pathway | 9 | 1.976511e-02 | 4 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 9 | 2.396469e-02 | 4 |
| KEGG | KEGG:05211 | Renal cell carcinoma | Renal cell carcinoma | 6 | 2.668755e-02 | 4 |
| KEGG | KEGG:04962 | Vasopressin-regulated water reabsorption | Vasopressin-regulated water reabsorption | 5 | 2.688326e-02 | 4 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | Fc gamma R-mediated phagocytosis | 7 | 2.706420e-02 | 4 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 10 | 2.755638e-02 | 4 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | Adipocytokine signaling pathway | 6 | 3.128764e-02 | 4 |
| KEGG | KEGG:04380 | Osteoclast differentiation | Osteoclast differentiation | 8 | 3.527471e-02 | 4 |
| KEGG | KEGG:05164 | Influenza A | Influenza A | 9 | 3.617393e-02 | 4 |
| KEGG | KEGG:05218 | Melanoma | Melanoma | 6 | 3.648773e-02 | 4 |
| KEGG | KEGG:04973 | Carbohydrate digestion and absorption | Carbohydrate digestion and absorption | 5 | 3.678557e-02 | 4 |
| KEGG | KEGG:05146 | Amoebiasis | Amoebiasis | 7 | 3.698075e-02 | 4 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | Vascular smooth muscle contraction | 8 | 3.712177e-02 | 4 |
| KEGG | KEGG:05135 | Yersinia infection | Yersinia infection | 8 | 4.314148e-02 | 4 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | C-type lectin receptor signaling pathway | 7 | 4.420503e-02 | 4 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | Thyroid hormone synthesis | 6 | 4.552988e-02 | 4 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | Parathyroid hormone synthesis, secretion and action | 7 | 4.684896e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 84 | 7.674290e-10 | 4 |
| HPA | HPA:0340000 | Ovary | Ovary | 99 | 2.927008e-09 | 4 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 79 | 2.209099e-07 | 4 |
| HPA | HPA:0050000 | Breast | Breast | 112 | 2.336380e-07 | 4 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 119 | 2.680157e-07 | 4 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 108 | 6.881888e-07 | 4 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 107 | 2.707371e-06 | 4 |
| HPA | HPA:0130241 | Colon; peripheral nerve/ganglion[≥Low] | Colon; peripheral nerve/ganglion[≥Low] | 89 | 3.005769e-06 | 4 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 81 | 3.380035e-06 | 4 |
| HPA | HPA:0130000 | Colon | Colon | 119 | 4.643420e-06 | 4 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 111 | 5.587939e-06 | 4 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 111 | 5.587939e-06 | 4 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 107 | 8.269126e-06 | 4 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 95 | 8.469094e-06 | 4 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 105 | 1.071884e-05 | 4 |
| HPA | HPA:0570000 | Testis | Testis | 123 | 1.159756e-05 | 4 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 29 | 1.403504e-05 | 4 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 111 | 1.687945e-05 | 4 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 31 | 2.069418e-05 | 4 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 97 | 2.735018e-05 | 4 |
| HPA | HPA:0630000 | Cervix | Cervix | 106 | 2.896932e-05 | 4 |
| HPA | HPA:0400000 | Rectum | Rectum | 115 | 3.062983e-05 | 4 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 107 | 3.713504e-05 | 4 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 29 | 3.835001e-05 | 4 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 102 | 3.946780e-05 | 4 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 110 | 4.258102e-05 | 4 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 29 | 4.542314e-05 | 4 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 109 | 4.652186e-05 | 4 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 109 | 4.652186e-05 | 4 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 93 | 4.931888e-05 | 4 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 114 | 5.339016e-05 | 4 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 97 | 5.928152e-05 | 4 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 24 | 6.519591e-05 | 4 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 95 | 9.129941e-05 | 4 |
| HPA | HPA:0030000 | Appendix | Appendix | 113 | 9.525939e-05 | 4 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 90 | 1.092118e-04 | 4 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 97 | 1.114164e-04 | 4 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 95 | 1.462224e-04 | 4 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 109 | 1.486191e-04 | 4 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 81 | 1.510626e-04 | 4 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 88 | 1.548686e-04 | 4 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 107 | 1.581930e-04 | 4 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 109 | 1.597010e-04 | 4 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 111 | 1.801186e-04 | 4 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 111 | 1.801186e-04 | 4 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 23 | 1.938275e-04 | 4 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 112 | 2.097701e-04 | 4 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 22 | 2.222150e-04 | 4 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 91 | 2.346272e-04 | 4 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 102 | 2.477005e-04 | 4 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 86 | 2.486177e-04 | 4 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 30 | 2.589836e-04 | 4 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 26 | 2.593473e-04 | 4 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 109 | 2.657099e-04 | 4 |
| HPA | HPA:0100211 | Cerebral cortex; neuropil[≥Low] | Cerebral cortex; neuropil[≥Low] | 84 | 2.834346e-04 | 4 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 97 | 3.011786e-04 | 4 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 92 | 3.044419e-04 | 4 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 104 | 3.138413e-04 | 4 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 110 | 3.433833e-04 | 4 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 110 | 3.433833e-04 | 4 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 24 | 3.773680e-04 | 4 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 24 | 4.064977e-04 | 4 |
| HPA | HPA:0380000 | Placenta | Placenta | 109 | 4.214333e-04 | 4 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 106 | 4.907193e-04 | 4 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 101 | 4.995341e-04 | 4 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 101 | 4.995341e-04 | 4 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 25 | 6.601282e-04 | 4 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 105 | 6.620274e-04 | 4 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 105 | 6.620274e-04 | 4 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 74 | 6.940016e-04 | 4 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 87 | 7.070349e-04 | 4 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 73 | 7.102126e-04 | 4 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 84 | 7.892597e-04 | 4 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 102 | 7.894297e-04 | 4 |
| HPA | HPA:0130242 | Colon; peripheral nerve/ganglion[≥Medium] | Colon; peripheral nerve/ganglion[≥Medium] | 64 | 7.989892e-04 | 4 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 72 | 1.067230e-03 | 4 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 24 | 1.151990e-03 | 4 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 83 | 1.160688e-03 | 4 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 26 | 1.204875e-03 | 4 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 96 | 1.327004e-03 | 4 |
| HPA | HPA:0530000 | Spleen | Spleen | 92 | 1.375330e-03 | 4 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 82 | 1.425179e-03 | 4 |
| HPA | HPA:0130051 | Colon; glandular cells[≥Low] | Colon; glandular cells[≥Low] | 103 | 1.439833e-03 | 4 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 102 | 1.554221e-03 | 4 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 102 | 1.554221e-03 | 4 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 81 | 1.582263e-03 | 4 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 26 | 1.609899e-03 | 4 |
| HPA | HPA:0270000 | Kidney | Kidney | 114 | 1.656463e-03 | 4 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 25 | 1.733141e-03 | 4 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 20 | 1.973632e-03 | 4 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 90 | 2.255511e-03 | 4 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 69 | 2.515635e-03 | 4 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 69 | 2.515635e-03 | 4 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 99 | 2.521152e-03 | 4 |
| HPA | HPA:0030051 | Appendix; glandular cells[≥Low] | Appendix; glandular cells[≥Low] | 100 | 2.536952e-03 | 4 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 84 | 2.666531e-03 | 4 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 82 | 2.669375e-03 | 4 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 89 | 2.678689e-03 | 4 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 91 | 3.051266e-03 | 4 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 91 | 3.051266e-03 | 4 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 53 | 3.428168e-03 | 4 |
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 78 | 3.483786e-03 | 4 |
| HPA | HPA:0290000 | Liver | Liver | 95 | 3.608852e-03 | 4 |
| HPA | HPA:0400052 | Rectum; glandular cells[≥Medium] | Rectum; glandular cells[≥Medium] | 93 | 3.705867e-03 | 4 |
| HPA | HPA:0150051 | Duodenum; glandular cells[≥Low] | Duodenum; glandular cells[≥Low] | 103 | 3.936926e-03 | 4 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 69 | 4.015354e-03 | 4 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 22 | 4.226677e-03 | 4 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 63 | 4.562352e-03 | 4 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 108 | 4.870348e-03 | 4 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 108 | 4.870348e-03 | 4 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 100 | 5.001147e-03 | 4 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 100 | 5.001147e-03 | 4 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 22 | 5.139736e-03 | 4 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 66 | 5.377338e-03 | 4 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 74 | 6.341610e-03 | 4 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 79 | 6.400530e-03 | 4 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 76 | 6.663444e-03 | 4 |
| HPA | HPA:0080000 | Caudate | Caudate | 101 | 6.910654e-03 | 4 |
| HPA | HPA:0270362 | Kidney; cells in tubules[≥Medium] | Kidney; cells in tubules[≥Medium] | 89 | 8.479299e-03 | 4 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 78 | 9.033818e-03 | 4 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 96 | 9.064147e-03 | 4 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 96 | 9.064147e-03 | 4 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 69 | 9.416987e-03 | 4 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 82 | 9.964041e-03 | 4 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 21 | 1.045207e-02 | 4 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 41 | 1.146528e-02 | 4 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 78 | 1.192514e-02 | 4 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 109 | 1.250166e-02 | 4 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 103 | 1.278367e-02 | 4 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 63 | 1.291515e-02 | 4 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 69 | 1.425042e-02 | 4 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 16 | 1.576631e-02 | 4 |
| HPA | HPA:0400051 | Rectum; glandular cells[≥Low] | Rectum; glandular cells[≥Low] | 101 | 1.592139e-02 | 4 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 13 | 1.696862e-02 | 4 |
| HPA | HPA:0390000 | Prostate | Prostate | 97 | 1.730836e-02 | 4 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 97 | 1.730836e-02 | 4 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 72 | 1.851798e-02 | 4 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 74 | 1.855492e-02 | 4 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 34 | 2.080071e-02 | 4 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 96 | 2.333770e-02 | 4 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 100 | 2.842802e-02 | 4 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 19 | 2.851137e-02 | 4 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 80 | 2.879623e-02 | 4 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 93 | 2.892047e-02 | 4 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 43 | 2.993229e-02 | 4 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 21 | 3.162427e-02 | 4 |
| HPA | HPA:0570731 | Testis; Leydig cells[≥Low] | Testis; Leydig cells[≥Low] | 101 | 3.170336e-02 | 4 |
| HPA | HPA:0130052 | Colon; glandular cells[≥Medium] | Colon; glandular cells[≥Medium] | 89 | 3.189696e-02 | 4 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 18 | 3.390512e-02 | 4 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 75 | 3.643876e-02 | 4 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 77 | 3.818784e-02 | 4 |
| HPA | HPA:0480051 | Small intestine; glandular cells[≥Low] | Small intestine; glandular cells[≥Low] | 100 | 4.073876e-02 | 4 |
| HPA | HPA:0510701 | Soft tissue 2; peripheral nerve[≥Low] | Soft tissue 2; peripheral nerve[≥Low] | 56 | 4.105637e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:126 | CCT complex (chaperonin containing TCP1 complex) | CCT complex (chaperonin containing TCP1 complex) | 6 | 4.331627e-07 | 4 |
| CORUM | CORUM:2112 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex | 4 | 3.391606e-05 | 4 |
| CORUM | CORUM:5269 | TNF-alpha/NF-kappa B signaling complex 8 | TNF-alpha/NF-kappa B signaling complex 8 | 4 | 4.910752e-04 | 4 |
| CORUM | CORUM:6512 | ILK-HSP90-CDC37 complex | ILK-HSP90-CDC37 complex | 3 | 1.528484e-03 | 4 |
| CORUM | CORUM:5268 | TNF-alpha/NF-kappa B signaling complex 7 | TNF-alpha/NF-kappa B signaling complex 7 | 4 | 2.212186e-03 | 4 |
| CORUM | CORUM:5199 | Kinase maturation complex 1 | Kinase maturation complex 1 | 5 | 2.657283e-03 | 4 |
| CORUM | CORUM:5286 | TNF-alpha/NF-kappa B signaling complex 10 | TNF-alpha/NF-kappa B signaling complex 10 | 4 | 6.406568e-03 | 4 |
| CORUM | CORUM:6247 | BBS-chaperonin complex | BBS-chaperonin complex | 4 | 6.406568e-03 | 4 |
| CORUM | CORUM:32 | PA700 complex | PA700 complex | 5 | 8.772901e-03 | 4 |
| CORUM | CORUM:5285 | TNF-alpha/NF-kappa B signaling complex 9 | TNF-alpha/NF-kappa B signaling complex 9 | 3 | 1.478055e-02 | 4 |
| CORUM | CORUM:5234 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex | 3 | 1.478055e-02 | 4 |
| CORUM | CORUM:5266 | TNF-alpha/NF-kappa B signaling complex 6 | TNF-alpha/NF-kappa B signaling complex 6 | 4 | 2.069027e-02 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 37 | 0.000003 | 4 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 28 | 0.000009 | 4 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 32 | 0.000070 | 4 |
| MIRNA | MIRNA:hsa-mir-324-3p | hsa-mir-324-3p | hsa-mir-324-3p | 35 | 0.000139 | 4 |
| MIRNA | MIRNA:hsa-mir-331-3p | hsa-mir-331-3p | hsa-mir-331-3p | 29 | 0.000890 | 4 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 15 | 0.001700 | 4 |
| MIRNA | MIRNA:hsa-mir-495 | hsa-mir-495 | hsa-mir-495 | 35 | 0.002242 | 4 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 34 | 0.003268 | 4 |
| MIRNA | MIRNA:hsa-mir-23b-3p | hsa-mir-23b-3p | hsa-mir-23b-3p | 13 | 0.003390 | 4 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 21 | 0.006966 | 4 |
| MIRNA | MIRNA:hsa-mir-944 | hsa-mir-944 | hsa-mir-944 | 29 | 0.008953 | 4 |
| MIRNA | MIRNA:hsa-mir-218-5p | hsa-mir-218-5p | hsa-mir-218-5p | 20 | 0.020088 | 4 |
| MIRNA | MIRNA:hsa-mir-149-5p | hsa-mir-149-5p | hsa-mir-149-5p | 13 | 0.024676 | 4 |
| MIRNA | MIRNA:hsa-mir-484 | hsa-mir-484 | hsa-mir-484 | 35 | 0.035337 | 4 |
| MIRNA | MIRNA:hsa-mir-455-3p | hsa-mir-455-3p | hsa-mir-455-3p | 27 | 0.037434 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100315 | Lewy bodies | Lewy bodies | 8 | 0.000004 | 4 |
| HP | HP:0100314 | Cerebral inclusion bodies | Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain. | 9 | 0.000024 | 4 |
| HP | HP:0011960 | Substantia nigra gliosis | Focal proliferation of glial cells in the substantia nigra. | 5 | 0.000762 | 4 |
| HP | HP:0002171 | Gliosis | Gliosis is the focal proliferation of glial cells in the central nervous system. | 10 | 0.001057 | 4 |
| HP | HP:0002362 | Shuffling gait | A type of gait (walking) characterized by by dragging one's feet along or without lifting the feet fully from the ground. | 7 | 0.001573 | 4 |
| HP | HP:0002322 | Resting tremor | A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse. | 8 | 0.001579 | 4 |
| HP | HP:0002548 | Parkinsonism with favorable response to dopaminergic medication | Parkinsonism is a clinical syndrome that is a feature of a number of different diseases, including Parkinson disease itself, other neurodegenerative diseases such as progressive supranuclear palsy, and as a side-effect of some neuroleptic medications. Some but not all individuals with Parkinsonism show responsiveness to dopaminergic medication defined as a substantial reduction of amelioration of the component signs of Parkinsonism (including mainly tremor, bradykinesia, rigidity, and postural instability) upon administration of dopaminergic medication. | 6 | 0.001921 | 4 |
| HP | HP:0001300 | Parkinsonism | Characteristic neurologic anomaly resulting from degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait. | 11 | 0.003051 | 4 |
| HP | HP:0002172 | Postural instability | A tendency to fall or the inability to keep oneself from falling; imbalance. The retropulsion test is widely regarded as the gold standard to evaluate postural instability, Use of the retropulsion test includes a rapid balance perturbation in the backward direction, and the number of balance correcting steps (or total absence thereof) is used to rate the degree of postural instability. Healthy subjects correct such perturbations with either one or two large steps, or without taking any steps, hinging rapidly at the hips while swinging the arms forward as a counterweight. In patients with balance impairment, balance correcting steps are often too small, forcing patients to take more than two steps. Taking three or more steps is generally considered to be abnormal, and taking more than five steps is regarded as being clearly abnormal. Markedly affected patients continue to step backward without ever regaining their balance and must be caught by the examiner (this would be called true retropulsion). Even more severely affected patients fail to correct entirely, and fall backward like a pushed toy soldier, without taking any corrective steps. | 9 | 0.005788 | 4 |
| HP | HP:0031435 | Monotonic speech | A speech pattern characterized by a persistently abnormal lack of tone in the voice. Monotonic speech is typically ongoing, lasting throughout the day, but may have a diurnal variation in the pattern, i.e. slower at specific times of the day. | 4 | 0.006021 | 4 |
| HP | HP:0003587 | Insidious onset | Gradual, very slow onset of disease manifestations. | 5 | 0.006462 | 4 |
| HP | HP:0008364 | Abnormality of the calcaneus | An abnormality of the calcaneus, also known as the heel bone, one of the or heel bone, one of the components of the tarsus of the foot which make up the heel. | 6 | 0.011482 | 4 |
| HP | HP:0045007 | Abnormal substantia nigra morphology | A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry. | 5 | 0.014179 | 4 |
| HP | HP:0011008 | Temporal pattern | The speed at which disease manifestations appear and develop. | 5 | 0.017927 | 4 |
| HP | HP:0002538 | Abnormal cerebral cortex morphology | Any structural abnormality of the cerebral cortex. | 23 | 0.045583 | 4 |
| HP | HP:0011877 | Increased mean platelet volume | Average platelet volume above the upper limit of the normal reference interval. | 5 | 0.049675 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M08309 | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN | 126 | 0.000446 | 4 |
| TF | TF:M07206 | Factor: E2F-1; motif: NGGGCGGGARV | Factor: E2F-1; motif: NGGGCGGGARV | 137 | 0.000479 | 4 |
| TF | TF:M12666 | Factor: SP1; motif: GGCCCCGCCCCCN | Factor: SP1; motif: GGCCCCGCCCCCN | 98 | 0.000636 | 4 |
| TF | TF:M00196 | Factor: Sp1; motif: NGGGGGCGGGGYN | Factor: Sp1; motif: NGGGGGCGGGGYN | 109 | 0.001149 | 4 |
| TF | TF:M12151 | Factor: Sp1; motif: NWRGCCMCGCCCMCN | Factor: Sp1; motif: NWRGCCMCGCCCMCN | 82 | 0.001975 | 4 |
| TF | TF:M11601_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 114 | 0.002083 | 4 |
| TF | TF:M02036_1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | 69 | 0.002209 | 4 |
| TF | TF:M01660 | Factor: GABP-alpha; motif: CTTCCK | Factor: GABP-alpha; motif: CTTCCK | 113 | 0.003841 | 4 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 143 | 0.004122 | 4 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 117 | 0.004683 | 4 |
| TF | TF:M02070 | Factor: TEL1; motif: CNCGGAANNN | Factor: TEL1; motif: CNCGGAANNN | 111 | 0.004888 | 4 |
| TF | TF:M07395 | Factor: Sp1; motif: NGGGGCGGGGN | Factor: Sp1; motif: NGGGGCGGGGN | 110 | 0.005594 | 4 |
| TF | TF:M09950_1 | Factor: HSF1; motif: NRGAANNTTCYRGAA; match class: 1 | Factor: HSF1; motif: NRGAANNTTCYRGAA; match class: 1 | 11 | 0.008827 | 4 |
| TF | TF:M09765 | Factor: SP1; motif: NRGKGGGCGGGGCN | Factor: SP1; motif: NRGKGGGCGGGGCN | 85 | 0.012031 | 4 |
| TF | TF:M08226_1 | Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 | Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 | 69 | 0.014513 | 4 |
| TF | TF:M11656_1 | Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1 | Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1 | 10 | 0.017571 | 4 |
| TF | TF:M00932 | Factor: Sp1; motif: NNGGGGCGGGGNN | Factor: Sp1; motif: NNGGGGCGGGGNN | 107 | 0.018018 | 4 |
| TF | TF:M00931 | Factor: Sp1; motif: GGGGCGGGGC | Factor: Sp1; motif: GGGGCGGGGC | 106 | 0.018021 | 4 |
| TF | TF:M02053 | Factor: ELF1; motif: NCCGGAARTN | Factor: ELF1; motif: NCCGGAARTN | 72 | 0.019483 | 4 |
| TF | TF:M02059 | Factor: ELK-1; motif: ACCGGAAGTN | Factor: ELK-1; motif: ACCGGAAGTN | 99 | 0.019613 | 4 |
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 131 | 0.022317 | 4 |
| TF | TF:M00736 | Factor: E2F-1:DP-1; motif: TTTCSCGC | Factor: E2F-1:DP-1; motif: TTTCSCGC | 106 | 0.022951 | 4 |
| TF | TF:M02089_1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | 99 | 0.023419 | 4 |
| TF | TF:M07395_1 | Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 | Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 | 75 | 0.026453 | 4 |
| TF | TF:M13135 | Factor: SP4; motif: GGCCCCGCCCCCN | Factor: SP4; motif: GGCCCCGCCCCCN | 68 | 0.029266 | 4 |
| TF | TF:M02052 | Factor: EHF; motif: CSCGGAARTN | Factor: EHF; motif: CSCGGAARTN | 103 | 0.035173 | 4 |
| TF | TF:M03807 | Factor: SP2; motif: GNNGGGGGCGGGGSN | Factor: SP2; motif: GNNGGGGGCGGGGSN | 91 | 0.039027 | 4 |
| TF | TF:M08911 | Factor: CTCF; motif: NCCRSTAGGGGGCGC | Factor: CTCF; motif: NCCRSTAGGGGGCGC | 96 | 0.041809 | 4 |
| TF | TF:M12173_1 | Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 | Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 | 62 | 0.048775 | 4 |
| TF | TF:M09723_1 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 | 71 | 0.049361 | 4 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:177 | OGT-TRAK1-TRAK2 complex | OGT-TRAK1-TRAK2 complex | 2 | 0.002292 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9013425 | RHOT1 GTPase cycle | RHOT1 GTPase cycle | 2 | 0.005511 | 0 |
| REAC | REAC:R-HSA-9013419 | RHOT2 GTPase cycle | RHOT2 GTPase cycle | 2 | 0.011554 | 0 |
| REAC | REAC:R-HSA-9715370 | Miro GTPase Cycle | Miro GTPase Cycle | 2 | 0.015393 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051018 | protein kinase A binding | "Binding to a protein kinase A." [GOC:ai] | 3 | 0.012932 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-512-3p | hsa-mir-512-3p | hsa-mir-512-3p | 10 | 0.025402 | 0 |
| MIRNA | MIRNA:hsa-mir-4473 | hsa-mir-4473 | hsa-mir-4473 | 6 | 0.032516 | 0 |
| MIRNA | MIRNA:hsa-mir-633 | hsa-mir-633 | hsa-mir-633 | 7 | 0.046259 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0098957 | anterograde axonal transport of mitochondrion | "The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [GOC:dos] | 2 | 0.034999 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04660 | T cell receptor signaling pathway | T cell receptor signaling pathway | 3 | 0.037786 | 0 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 13 | 1.030146e-12 | 1 |
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 8 | 1.074415e-08 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 8 | 0.000210 | 1 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 8 | 0.000259 | 1 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 8 | 0.000404 | 1 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 8 | 0.002383 | 1 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 8 | 0.002948 | 1 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 8 | 0.003127 | 1 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 8 | 0.004062 | 1 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 8 | 0.006895 | 1 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 8 | 0.007287 | 1 |
| GO:MF | GO:0002161 | aminoacyl-tRNA deacylase activity | "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889] | 2 | 0.009425 | 1 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 8 | 0.010182 | 1 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 8 | 0.010852 | 1 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 8 | 0.015506 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0106074 | aminoacyl-tRNA metabolism involved in translational fidelity | "Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation." [GOC:hjd] | 2 | 0.024775 | 1 |
| GO:BP | GO:1903427 | negative regulation of reactive oxygen species biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] | 2 | 0.028307 | 1 |
| GO:BP | GO:0006450 | regulation of translational fidelity | "Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] | 2 | 0.049474 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00970 | Aminoacyl-tRNA biosynthesis | Aminoacyl-tRNA biosynthesis | 2 | 0.02636 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-let-7b-5p | hsa-let-7b-5p | hsa-let-7b-5p | 6 | 0.033273 | 1 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030877 | beta-catenin destruction complex | "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] | 2 | 0.000744 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0070411 | I-SMAD binding | "Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 2 | 0.001476 | 2 |
| GO:MF | GO:0046332 | SMAD binding | "Binding to a SMAD signaling protein." [GOC:ai] | 2 | 0.037580 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0009950 | dorsal/ventral axis specification | "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] | 2 | 0.002798 | 2 |
| GO:BP | GO:0045668 | negative regulation of osteoblast differentiation | "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] | 2 | 0.043784 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05213 | Endometrial cancer | Endometrial cancer | 2 | 0.014672 | 2 |
| KEGG | KEGG:05217 | Basal cell carcinoma | Basal cell carcinoma | 2 | 0.017321 | 2 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 2 | 0.032299 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4155 | Endometrial cancer | Endometrial cancer | 2 | 0.025605 | 2 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 2 | 0.034402 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4641257 | Degradation of AXIN | Degradation of AXIN | 2 | 0.048203 | 2 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00785 | Lipoic acid metabolism | Lipoic acid metabolism | 1 | 0.036474 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0036255 | response to methylamine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [GOC:mah] | 1 | 0.049542 | 3 |
| GO:BP | GO:1903442 | response to lipoic acid | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760] | 1 | 0.049542 | 3 |
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004375 | glycine dehydrogenase (decarboxylating) activity | "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2] | 1 | 0.049891 | 3 |
| GO:MF | GO:0016642 | oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] | 1 | 0.049891 | 3 |
| GO:MF | GO:0070280 | pyridoxal binding | "Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6." [CHEBI:17310, GOC:mah] | 1 | 0.049891 | 3 |