Positive Kinase

biogrid+hippie (Leiden)

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source	term_id	annotation	description	intersection_size	p_value
GO:MF	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	29	4.212838e-29
GO:MF	GO:0044389	ubiquitin-like protein ligase binding	"Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]	29	2.276740e-28
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	50	4.713394e-25
GO:MF	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	27	3.136444e-17
GO:MF	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	11	1.387415e-16
GO:MF	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	46	5.117901e-14
GO:MF	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	58	8.636170e-13
GO:MF	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	11	2.218303e-12
GO:MF	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	28	1.707847e-11
GO:MF	GO:0097718	disordered domain specific binding	"Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698]	8	1.322780e-10
GO:MF	GO:0030674	protein-macromolecule adaptor activity	"An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	25	2.113148e-10
GO:MF	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	17	2.183962e-10
GO:MF	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	34	1.165325e-09
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	15	4.242287e-09
GO:MF	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	26	6.054283e-09
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	85	7.696643e-09
GO:MF	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	10	2.073062e-08
GO:MF	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	20	3.724648e-08
GO:MF	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	10	4.463785e-08
GO:MF	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	19	4.901746e-08
GO:MF	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	10	6.659584e-08
GO:MF	GO:0017076	purine nucleotide binding	"Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]	31	3.317747e-07
GO:MF	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	17	3.780445e-07
GO:MF	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	14	7.985683e-07
GO:MF	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	26	8.768657e-07
GO:MF	GO:0035639	purine ribonucleoside triphosphate binding	"Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732]	29	1.339123e-06
GO:MF	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	16	1.612989e-06
GO:MF	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	31	1.891273e-06
GO:MF	GO:1901265	nucleoside phosphate binding	"Binding to nucleoside phosphate." [GOC:TermGenie]	31	2.265014e-06
GO:MF	GO:0032555	purine ribonucleotide binding	"Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	29	2.566085e-06
GO:MF	GO:0032553	ribonucleotide binding	"Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	29	3.072010e-06
GO:MF	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	16	3.771561e-06
GO:MF	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	24	4.016759e-06
GO:MF	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	15	5.622698e-06
GO:MF	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	32	6.459970e-06
GO:MF	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	24	6.829933e-06
GO:MF	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	31	7.077385e-06
GO:MF	GO:0036094	small molecule binding	"Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]	53	7.115196e-06
GO:MF	GO:0043167	ion binding	"Binding to an ion, a charged atoms or groups of atoms." [GOC:jl]	52	7.709829e-06
GO:MF	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	31	8.214401e-06
GO:MF	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	8	1.271683e-05
GO:MF	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	8	3.773424e-05
GO:MF	GO:0017111	ribonucleoside triphosphate phosphatase activity	"Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680]	20	4.155942e-05
GO:MF	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	13	6.201843e-05
GO:MF	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	20	9.154648e-05
GO:MF	GO:0016817	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	20	9.272174e-05
GO:MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	20	9.272174e-05
GO:MF	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	29	1.035786e-04
GO:MF	GO:0042162	telomeric DNA binding	"Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]	5	2.505777e-04
GO:MF	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	6	2.992292e-04
GO:MF	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	8	3.337596e-04
GO:MF	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	12	4.311880e-04
GO:MF	GO:0140693	molecular condensate scaffold activity	"Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate." [PMID:28225081]	5	5.960248e-04
GO:MF	GO:0030235	nitric-oxide synthase regulator activity	"Binds to and modulates the activity of nitric oxide synthase." [GOC:mah]	3	1.187253e-03
GO:MF	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	7	1.243961e-03
GO:MF	GO:0140296	general transcription initiation factor binding	"Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation." [GOC:txnOH-2018]	5	1.363571e-03
GO:MF	GO:0023026	MHC class II protein complex binding	"Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw]	4	1.386254e-03
GO:MF	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	28	3.813631e-03
GO:MF	GO:0004517	nitric-oxide synthase activity	"Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, RHEA:19897]	3	4.033624e-03
GO:MF	GO:0098505	G-rich strand telomeric DNA binding	"Binding to G-rich, single-stranded, telomere-associated DNA." [PMID:11349150]	3	4.033624e-03
GO:MF	GO:0001221	transcription coregulator binding	"Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc]	6	4.983327e-03
GO:MF	GO:0023023	MHC protein complex binding	"Binding to a major histocompatibility complex." [GOC:mtg_signal, GOC:vw]	4	5.186856e-03
GO:MF	GO:0140666	annealing activity	"An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule." [PMID:22888405]	3	5.529402e-03
GO:MF	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	20	6.193420e-03
GO:MF	GO:0043047	single-stranded telomeric DNA binding	"Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]	3	7.350167e-03
GO:MF	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	9	7.413963e-03
GO:MF	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	7	7.597726e-03
GO:MF	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	5	8.139101e-03
GO:MF	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	6	1.029070e-02
GO:MF	GO:0098847	sequence-specific single stranded DNA binding	"Binding to single-stranded DNA of a specific nucleotide composition." [PMID:9531483]	3	1.208752e-02
GO:MF	GO:0048156	tau protein binding	"Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]	4	1.515088e-02
GO:MF	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	47	1.604008e-02
GO:MF	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	3	1.848358e-02
GO:MF	GO:1990381	ubiquitin-specific protease binding	"Binding to a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750]	3	2.677017e-02
GO:MF	GO:0061980	regulatory RNA binding	"Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme." [PMID:14622403, PMID:23475961]	4	2.990603e-02
GO:MF	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	15	3.025899e-02
GO:MF	GO:0008013	beta-catenin binding	"Binding to a catenin beta subunit." [GOC:bf]	5	4.421023e-02
GO:MF	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	7	4.534824e-02
GO:MF	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	4	4.965166e-02
GO:MF	GO:0140677	molecular function activator activity	"A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	15	4.974161e-02

source	term_id	annotation	description	intersection_size	p_value
GO:BP	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	60	1.116851e-24
GO:BP	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	68	6.116466e-23
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	56	1.614096e-22
GO:BP	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	44	1.358808e-21
GO:BP	GO:0009891	positive regulation of biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	51	1.392518e-21
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	44	2.362929e-21
GO:BP	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	19	1.361855e-19
GO:BP	GO:0043067	regulation of programmed cell death	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	39	1.658670e-19
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	"Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	48	2.515115e-19
GO:BP	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	43	4.053338e-19
GO:BP	GO:0043069	negative regulation of programmed cell death	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	32	4.331502e-19
GO:BP	GO:0008219	cell death	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]	43	4.386604e-19
GO:BP	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	38	6.620819e-19
GO:BP	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	69	6.637656e-19
GO:BP	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	42	1.164284e-18
GO:BP	GO:0080134	regulation of response to stress	"Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	37	1.218743e-18
GO:BP	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	31	2.173109e-18
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	37	2.534977e-18
GO:BP	GO:0032200	telomere organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah]	19	2.666101e-18
GO:BP	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	70	1.055172e-17
GO:BP	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	65	1.976697e-17
GO:BP	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	49	2.616044e-17
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	"Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	47	2.619140e-17
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	59	2.702293e-17
GO:BP	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	32	2.760642e-17
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	32	2.841125e-17
GO:BP	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	66	6.196095e-17
GO:BP	GO:0009890	negative regulation of biosynthetic process	"Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	47	7.302777e-17
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	"Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	41	9.617550e-17
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	49	1.473431e-16
GO:BP	GO:2001233	regulation of apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	22	1.729534e-16
GO:BP	GO:1902531	regulation of intracellular signal transduction	"Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	40	1.918942e-16
GO:BP	GO:0051253	negative regulation of RNA metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	35	1.974732e-16
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	"Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	36	3.405485e-16
GO:BP	GO:0009889	regulation of biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	63	4.632988e-16
GO:BP	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	53	9.199281e-16
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	"Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	53	1.501811e-15
GO:BP	GO:0048583	regulation of response to stimulus	"Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	53	1.554953e-15
GO:BP	GO:0033365	protein localization to organelle	"A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]	32	2.455938e-15
GO:BP	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	49	2.618578e-15
GO:BP	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	32	2.641223e-15
GO:BP	GO:0009056	catabolic process	"A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	44	2.952328e-15
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	"Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	61	5.541343e-15
GO:BP	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	42	8.285071e-15
GO:BP	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	49	9.455708e-15
GO:BP	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	49	1.042744e-14
GO:BP	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	28	1.260978e-14
GO:BP	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	24	1.828678e-14
GO:BP	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	60	3.407342e-14
GO:BP	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	49	3.806361e-14
GO:BP	GO:0034504	protein localization to nucleus	"A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]	19	4.288997e-14
GO:BP	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	19	1.128295e-13
GO:BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	"Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	17	1.348459e-13
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	43	1.384424e-13
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	43	1.626455e-13
GO:BP	GO:1901873	regulation of post-translational protein modification	"Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]	17	1.911637e-13
GO:BP	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	60	2.153518e-13
GO:BP	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	28	2.190182e-13
GO:BP	GO:0010833	telomere maintenance via telomere lengthening	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb]	12	2.295750e-13
GO:BP	GO:0030162	regulation of proteolysis	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]	20	2.352605e-13
GO:BP	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	44	2.577410e-13
GO:BP	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	31	3.351949e-13
GO:BP	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	28	3.355103e-13
GO:BP	GO:0023057	negative regulation of signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	32	3.550028e-13
GO:BP	GO:0010648	negative regulation of cell communication	"Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	32	3.621651e-13
GO:BP	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	81	3.768010e-13
GO:BP	GO:2001242	regulation of intrinsic apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	15	7.713904e-13
GO:BP	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	66	7.965565e-13
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	45	9.949706e-13
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	30	1.135518e-12
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	"Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	30	1.587032e-12
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	23	1.702678e-12
GO:BP	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	27	1.802164e-12
GO:BP	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	21	1.880257e-12
GO:BP	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	16	1.964222e-12
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	47	3.430554e-12
GO:BP	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	57	3.894411e-12
GO:BP	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	33	4.118492e-12
GO:BP	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	38	5.227524e-12
GO:BP	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	24	6.288286e-12
GO:BP	GO:0019941	modification-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]	22	9.456950e-12
GO:BP	GO:0043632	modification-dependent macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl]	22	1.109926e-11
GO:BP	GO:0097193	intrinsic apoptotic signaling pathway	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]	17	1.152060e-11
GO:BP	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	21	1.381040e-11
GO:BP	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	26	2.863561e-11
GO:BP	GO:1904356	regulation of telomere maintenance via telomere lengthening	"Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]	10	3.136024e-11
GO:BP	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]	80	3.544266e-11
GO:BP	GO:0009628	response to abiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]	27	4.246491e-11
GO:BP	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	70	4.408714e-11
GO:BP	GO:0032204	regulation of telomere maintenance	"Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]	12	4.873092e-11
GO:BP	GO:0051254	positive regulation of RNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	33	5.239603e-11
GO:BP	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	41	5.390247e-11
GO:BP	GO:1903050	regulation of proteolysis involved in protein catabolic process	"Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]	15	5.617190e-11
GO:BP	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	30	6.073825e-11
GO:BP	GO:0009059	macromolecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	72	6.552745e-11
GO:BP	GO:0010821	regulation of mitochondrion organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]	12	6.738906e-11
GO:BP	GO:0070647	protein modification by small protein conjugation or removal	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah]	25	7.861581e-11
GO:BP	GO:0007004	telomere maintenance via telomerase	"The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh]	10	7.955052e-11
GO:BP	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	21	8.042597e-11
GO:BP	GO:0061136	regulation of proteasomal protein catabolic process	"Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb]	14	9.388492e-11
GO:BP	GO:0031396	regulation of protein ubiquitination	"Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	14	9.388492e-11
GO:BP	GO:0006278	RNA-templated DNA biosynthetic process	"A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732]	10	1.335595e-10
GO:BP	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	34	1.411463e-10
GO:BP	GO:0051252	regulation of RNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	45	1.525137e-10
GO:BP	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	17	1.798850e-10
GO:BP	GO:0034605	cellular response to heat	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]	10	1.858765e-10
GO:BP	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	18	1.925186e-10
GO:BP	GO:0090304	nucleic acid metabolic process	"Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb]	63	2.773029e-10
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	24	3.011054e-10
GO:BP	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	13	3.145870e-10
GO:BP	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	23	3.655148e-10
GO:BP	GO:0045862	positive regulation of proteolysis	"Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]	14	3.802774e-10
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	65	4.175981e-10
GO:BP	GO:0009408	response to heat	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]	11	5.201077e-10
GO:BP	GO:1901698	response to nitrogen compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	25	7.771802e-10
GO:BP	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	69	1.179701e-09
GO:BP	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	30	1.486115e-09
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	30	1.925568e-09
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	30	1.984751e-09
GO:BP	GO:0002218	activation of innate immune response	"Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]	15	2.357999e-09
GO:BP	GO:0035966	response to topologically incorrect protein	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf]	12	2.909728e-09
GO:BP	GO:0033043	regulation of organelle organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]	25	2.999809e-09
GO:BP	GO:0009719	response to endogenous stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]	28	3.272527e-09
GO:BP	GO:0031399	regulation of protein modification process	"Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	24	3.314126e-09
GO:BP	GO:0051248	negative regulation of protein metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]	20	3.526512e-09
GO:BP	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	20	4.487798e-09
GO:BP	GO:0008152	metabolic process	"A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	82	5.544798e-09
GO:BP	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	44	6.644276e-09
GO:BP	GO:0051129	negative regulation of cellular component organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	20	6.654369e-09
GO:BP	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	18	7.137033e-09
GO:BP	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	41	7.471814e-09
GO:BP	GO:0009266	response to temperature stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb]	12	7.501462e-09
GO:BP	GO:0070887	cellular response to chemical stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]	33	7.707434e-09
GO:BP	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	18	8.071743e-09
GO:BP	GO:0010647	positive regulation of cell communication	"Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	30	8.085102e-09
GO:BP	GO:0023056	positive regulation of signaling	"Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	30	8.200308e-09
GO:BP	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	11	8.668198e-09
GO:BP	GO:0006913	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	15	8.677936e-09
GO:BP	GO:0051169	nuclear transport	"The directed movement of substances into, out of, or within the nucleus." [GOC:ai]	15	8.677936e-09
GO:BP	GO:0009896	positive regulation of catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	18	8.846396e-09
GO:BP	GO:2001141	regulation of RNA biosynthetic process	"Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]	41	8.984530e-09
GO:BP	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	22	1.131218e-08
GO:BP	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	37	1.656680e-08
GO:BP	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	11	1.672461e-08
GO:BP	GO:1904358	positive regulation of telomere maintenance via telomere lengthening	"Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]	7	2.182263e-08
GO:BP	GO:0032210	regulation of telomere maintenance via telomerase	"Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]	8	2.216356e-08
GO:BP	GO:0051052	regulation of DNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]	17	2.327752e-08
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	26	2.548660e-08
GO:BP	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	76	2.565790e-08
GO:BP	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	10	2.634488e-08
GO:BP	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	10	2.634488e-08
GO:BP	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	41	2.819820e-08
GO:BP	GO:0033044	regulation of chromosome organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]	13	2.848403e-08
GO:BP	GO:1900180	regulation of protein localization to nucleus	"Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]	11	3.100532e-08
GO:BP	GO:0009058	biosynthetic process	"A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	72	3.156425e-08
GO:BP	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	8	3.184619e-08
GO:BP	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419]	20	3.463486e-08
GO:BP	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	24	4.089103e-08
GO:BP	GO:0045089	positive regulation of innate immune response	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]	15	4.326728e-08
GO:BP	GO:0007049	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]	28	4.592087e-08
GO:BP	GO:1903311	regulation of mRNA metabolic process	"Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	14	4.879726e-08
GO:BP	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	28	4.999722e-08
GO:BP	GO:0045088	regulation of innate immune response	"Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]	16	5.046885e-08
GO:BP	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	22	5.412066e-08
GO:BP	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	15	5.416108e-08
GO:BP	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	23	7.261961e-08
GO:BP	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	27	8.189371e-08
GO:BP	GO:0071495	cellular response to endogenous stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]	24	8.301053e-08
GO:BP	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	53	9.566940e-08
GO:BP	GO:0043412	macromolecule modification	"The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]	37	1.076379e-07
GO:BP	GO:0002833	positive regulation of response to biotic stimulus	"Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]	15	1.113991e-07
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	34	1.253456e-07
GO:BP	GO:0071840	cellular component organization or biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]	63	1.343048e-07
GO:BP	GO:0002253	activation of immune response	"Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]	17	1.369431e-07
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	24	1.438334e-07
GO:BP	GO:0044419	biological process involved in interspecies interaction between organisms	"Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]	28	1.714767e-07
GO:BP	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	62	1.749681e-07
GO:BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	15	1.802823e-07
GO:BP	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	11	1.837086e-07
GO:BP	GO:0034097	response to cytokine	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl]	21	1.959023e-07
GO:BP	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	55	2.052109e-07
GO:BP	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	76	2.115673e-07
GO:BP	GO:0141124	intracellular signaling cassette	"An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg]	29	2.219450e-07
GO:BP	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	20	2.293821e-07
GO:BP	GO:0016032	viral process	"A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah]	15	2.433575e-07
GO:BP	GO:1901652	response to peptide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]	21	2.615259e-07
GO:BP	GO:0051054	positive regulation of DNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]	13	2.835397e-07
GO:BP	GO:0031349	positive regulation of defense response	"Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah]	16	2.952268e-07
GO:BP	GO:0140546	defense response to symbiont	"Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg]	22	3.345904e-07
GO:BP	GO:0009895	negative regulation of catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	14	3.358085e-07
GO:BP	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	50	3.375994e-07
GO:BP	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]	10	3.513910e-07
GO:BP	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	22	3.652488e-07
GO:BP	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	17	3.682459e-07
GO:BP	GO:0061919	process utilizing autophagic mechanism	"A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378]	17	3.682459e-07
GO:BP	GO:0006986	response to unfolded protein	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]	10	4.681719e-07
GO:BP	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	34	4.948952e-07
GO:BP	GO:0048511	rhythmic process	"Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid]	13	5.059940e-07
GO:BP	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	12	5.893001e-07
GO:BP	GO:1903312	negative regulation of mRNA metabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	9	5.893751e-07
GO:BP	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	20	6.609150e-07
GO:BP	GO:0034655	nucleobase-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	16	6.668474e-07
GO:BP	GO:0031347	regulation of defense response	"Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah]	19	6.954197e-07
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	29	7.290801e-07
GO:BP	GO:0051084	'de novo' post-translational protein folding	"The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb]	7	7.522406e-07
GO:BP	GO:0002831	regulation of response to biotic stimulus	"Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]	16	7.635624e-07
GO:BP	GO:0062197	cellular response to chemical stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712]	13	8.125091e-07
GO:BP	GO:1901796	regulation of signal transduction by p53 class mediator	"Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]	9	8.341990e-07
GO:BP	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	32	8.370465e-07
GO:BP	GO:0032212	positive regulation of telomere maintenance via telomerase	"Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]	6	8.975028e-07
GO:BP	GO:0051131	chaperone-mediated protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]	6	8.975028e-07
GO:BP	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	18	9.465977e-07
GO:BP	GO:0032870	cellular response to hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah]	17	1.018941e-06
GO:BP	GO:0009607	response to biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]	26	1.023515e-06
GO:BP	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	8	1.169809e-06
GO:BP	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	17	1.203269e-06
GO:BP	GO:0032206	positive regulation of telomere maintenance	"Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]	8	1.305278e-06
GO:BP	GO:0002221	pattern recognition receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]	12	1.436785e-06
GO:BP	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	9	1.482769e-06
GO:BP	GO:0007623	circadian rhythm	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]	11	1.552390e-06
GO:BP	GO:0042752	regulation of circadian rhythm	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]	9	1.604688e-06
GO:BP	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	12	1.631913e-06
GO:BP	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	76	1.735084e-06
GO:BP	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	6	1.955066e-06
GO:BP	GO:0010638	positive regulation of organelle organization	"Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]	15	1.960460e-06
GO:BP	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	8	2.206889e-06
GO:BP	GO:1903829	positive regulation of protein localization	"Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	15	2.377926e-06
GO:BP	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	11	2.419853e-06
GO:BP	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	31	2.559799e-06
GO:BP	GO:0045595	regulation of cell differentiation	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]	25	2.610388e-06
GO:BP	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	53	2.653862e-06
GO:BP	GO:0002758	innate immune response-activating signaling pathway	"The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an innate immune response." [GOC:jy, GOC:mah, PMID:11418339, PMID:28105028]	12	2.898354e-06
GO:BP	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	53	3.089957e-06
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	21	3.669430e-06
GO:BP	GO:0002753	cytoplasmic pattern recognition receptor signaling pathway	"The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967, PMID:17328678, PMID:18272355, PMID:19531363, PMID:21187438]	10	3.941036e-06
GO:BP	GO:0006109	regulation of carbohydrate metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators]	10	4.166472e-06
GO:BP	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	20	4.329638e-06
GO:BP	GO:0098542	defense response to other organism	"Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]	22	6.068669e-06
GO:BP	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	50	6.086670e-06
GO:BP	GO:0070848	response to growth factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah]	17	6.466346e-06
GO:BP	GO:0030522	intracellular receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a receptor located within a cell." [GOC:bf, GOC:mah]	13	6.657295e-06
GO:BP	GO:0006006	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	10	6.771185e-06
GO:BP	GO:2000278	regulation of DNA biosynthetic process	"Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	8	6.817892e-06
GO:BP	GO:2000767	positive regulation of cytoplasmic translation	"Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	5	7.929208e-06
GO:BP	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	12	8.073309e-06
GO:BP	GO:1900182	positive regulation of protein localization to nucleus	"Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]	8	8.817652e-06
GO:BP	GO:0032103	positive regulation of response to external stimulus	"Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah]	16	9.182361e-06
GO:BP	GO:0043255	regulation of carbohydrate biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl]	8	9.588335e-06
GO:BP	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	10	1.020726e-05
GO:BP	GO:0062012	regulation of small molecule metabolic process	"Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]	12	1.111506e-05
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	"Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb]	11	1.192958e-05
GO:BP	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	8	1.226048e-05
GO:BP	GO:0141187	nucleic acid biosynthetic process	"The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb]	53	1.289789e-05
GO:BP	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	13	1.352735e-05
GO:BP	GO:0032101	regulation of response to external stimulus	"Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	20	1.374691e-05
GO:BP	GO:0050778	positive regulation of immune response	"Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	17	1.417314e-05
GO:BP	GO:0030111	regulation of Wnt signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]	12	1.621252e-05
GO:BP	GO:0051707	response to other organism	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai]	24	1.676371e-05
GO:BP	GO:0008637	apoptotic mitochondrial changes	"The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis]	8	1.680934e-05
GO:BP	GO:0043207	response to external biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators]	24	1.739071e-05
GO:BP	GO:0002757	immune response-activating signaling pathway	"The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add]	14	1.910774e-05
GO:BP	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	8	1.958546e-05
GO:BP	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	10	2.302346e-05
GO:BP	GO:2001236	regulation of extrinsic apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	9	2.577602e-05
GO:BP	GO:0035967	cellular response to topologically incorrect protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf]	8	2.634497e-05
GO:BP	GO:0031400	negative regulation of protein modification process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	12	2.920335e-05
GO:BP	GO:0010639	negative regulation of organelle organization	"Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]	12	3.210664e-05
GO:BP	GO:0048869	cellular developmental process	"A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]	41	3.243788e-05
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	26	3.687392e-05
GO:BP	GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]	6	3.826590e-05
GO:BP	GO:0072331	signal transduction by p53 class mediator	"An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah]	9	3.986268e-05
GO:BP	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	9	4.429311e-05
GO:BP	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	10	4.453354e-05
GO:BP	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	10	4.844980e-05
GO:BP	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	12	5.089444e-05
GO:BP	GO:0039531	regulation of cytoplasmic pattern recognition receptor signaling pathway	"Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway." [GOC:bf, GOC:jl]	8	5.266071e-05
GO:BP	GO:0051170	import into nucleus	"The directed movement of substances into the nucleus." [GOC:ai]	9	5.730376e-05
GO:BP	GO:0002764	immune response-regulating signaling pathway	"The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]	14	5.839112e-05
GO:BP	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	18	5.902764e-05
GO:BP	GO:0062207	regulation of pattern recognition receptor signaling pathway	"Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168]	9	6.027328e-05
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	53	6.609450e-05
GO:BP	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	13	6.707845e-05
GO:BP	GO:0019220	regulation of phosphate metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	18	6.817403e-05
GO:BP	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	25	6.882312e-05
GO:BP	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	22	6.892009e-05
GO:BP	GO:0051174	regulation of phosphorus metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]	18	6.926701e-05
GO:BP	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	9	8.108135e-05
GO:BP	GO:0019058	viral life cycle	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]	11	8.914869e-05
GO:BP	GO:0070841	inclusion body assembly	"The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah]	5	9.376394e-05
GO:BP	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	14	9.381038e-05
GO:BP	GO:0051094	positive regulation of developmental process	"Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	21	9.811834e-05
GO:BP	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	15	1.022533e-04
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	11	1.049148e-04
GO:BP	GO:2000573	positive regulation of DNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	6	1.101992e-04
GO:BP	GO:0019079	viral genome replication	"Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534]	8	1.117520e-04
GO:BP	GO:1903322	positive regulation of protein modification by small protein conjugation or removal	"Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	8	1.117520e-04
GO:BP	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	40	1.149636e-04
GO:BP	GO:1901875	positive regulation of post-translational protein modification	"Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]	8	1.185794e-04
GO:BP	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	17	1.190773e-04
GO:BP	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	15	1.220166e-04
GO:BP	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	9	1.240183e-04
GO:BP	GO:0010332	response to gamma radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators]	6	1.241773e-04
GO:BP	GO:0005996	monosaccharide metabolic process	"The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732]	10	1.254887e-04
GO:BP	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	22	1.291656e-04
GO:BP	GO:0016049	cell growth	"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]	13	1.308781e-04
GO:BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	10	1.403358e-04
GO:BP	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	25	1.425490e-04
GO:BP	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194]	17	1.471175e-04
GO:BP	GO:0070934	CRD-mediated mRNA stabilization	"An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303]	4	1.594995e-04
GO:BP	GO:0018193	peptidyl-amino acid modification	"The alteration of an amino acid residue in a peptide." [GOC:mah]	15	1.659191e-04
GO:BP	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	15	1.755959e-04
GO:BP	GO:0009199	ribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	10	1.811534e-04
GO:BP	GO:0009144	purine nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	10	1.811534e-04
GO:BP	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	10	1.877655e-04
GO:BP	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	41	2.108630e-04
GO:BP	GO:0043254	regulation of protein-containing complex assembly	"Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl]	12	2.276789e-04
GO:BP	GO:0010906	regulation of glucose metabolic process	"Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]	7	2.347299e-04
GO:BP	GO:1900152	negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]	4	2.385213e-04
GO:BP	GO:0033993	response to lipid	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]	17	2.673460e-04
GO:BP	GO:0045861	negative regulation of proteolysis	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]	8	2.733600e-04
GO:BP	GO:0034614	cellular response to reactive oxygen species	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]	8	2.733600e-04
GO:BP	GO:0071396	cellular response to lipid	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah]	14	2.791140e-04
GO:BP	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:ai, GOC:mtg_apoptosis]	6	2.976914e-04
GO:BP	GO:0010038	response to metal ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]	11	3.130149e-04
GO:BP	GO:0009141	nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	10	3.158663e-04
GO:BP	GO:0002682	regulation of immune system process	"Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]	22	3.403355e-04
GO:BP	GO:1902253	regulation of intrinsic apoptotic signaling pathway by p53 class mediator	"Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]	5	3.476794e-04
GO:BP	GO:0062098	regulation of programmed necrotic cell death	"Any process that modulates the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785]	5	3.476794e-04
GO:BP	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	30	3.977266e-04
GO:BP	GO:0016236	macroautophagy	"The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]	11	4.263356e-04
GO:BP	GO:0010586	miRNA metabolic process	"The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]	7	4.647813e-04
GO:BP	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	18	4.743515e-04
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	"Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph]	6	4.834023e-04
GO:BP	GO:0043068	positive regulation of programmed cell death	"Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	13	5.120378e-04
GO:BP	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	7	5.283833e-04
GO:BP	GO:0043086	negative regulation of catalytic activity	"Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	10	5.489394e-04
GO:BP	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	18	5.502498e-04
GO:BP	GO:0044092	negative regulation of molecular function	"Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]	13	5.920159e-04
GO:BP	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	30	5.957425e-04
GO:BP	GO:0032885	regulation of polysaccharide biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah]	5	6.427796e-04
GO:BP	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	7	6.777632e-04
GO:BP	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	6	6.927026e-04
GO:BP	GO:0046034	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	9	6.957014e-04
GO:BP	GO:0097191	extrinsic apoptotic signaling pathway	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]	9	7.217035e-04
GO:BP	GO:2000765	regulation of cytoplasmic translation	"Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	5	7.408900e-04
GO:BP	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	27	7.416988e-04
GO:BP	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	16	7.577793e-04
GO:BP	GO:0006793	phosphorus metabolic process	"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]	27	7.605473e-04
GO:BP	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	52	7.618830e-04
GO:BP	GO:0000423	mitophagy	"The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367]	6	8.223325e-04
GO:BP	GO:0001649	osteoblast differentiation	"The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid]	9	8.343408e-04
GO:BP	GO:0007006	mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	7	8.612045e-04
GO:BP	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	10	8.683592e-04
GO:BP	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	8	9.956155e-04
GO:BP	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	10	1.066468e-03
GO:BP	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	19	1.088702e-03
GO:BP	GO:0070266	necroptotic process	"A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former." [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153]	5	1.107952e-03
GO:BP	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	30	1.128061e-03
GO:BP	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	10	1.196599e-03
GO:BP	GO:0038061	non-canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217]	7	1.213604e-03
GO:BP	GO:0090666	scaRNA localization to Cajal body	"A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]	3	1.274115e-03
GO:BP	GO:0072655	establishment of protein localization to mitochondrion	"The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah]	7	1.282718e-03
GO:BP	GO:0001558	regulation of cell growth	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	11	1.329366e-03
GO:BP	GO:0061614	miRNA transcription	"The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799]	6	1.335613e-03
GO:BP	GO:0043488	regulation of mRNA stability	"Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]	8	1.343137e-03
GO:BP	GO:0031669	cellular response to nutrient levels	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]	9	1.357477e-03
GO:BP	GO:0051093	negative regulation of developmental process	"Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	16	1.384516e-03
GO:BP	GO:0043489	RNA stabilization	"Prevention of degradation of RNA molecules." [GOC:go_curators]	6	1.442321e-03
GO:BP	GO:0016241	regulation of macroautophagy	"Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc]	8	1.521130e-03
GO:BP	GO:1902373	negative regulation of mRNA catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865]	6	1.555913e-03
GO:BP	GO:0018209	peptidyl-serine modification	"The modification of peptidyl-serine." [GOC:go_curators]	8	1.650674e-03
GO:BP	GO:0031667	response to nutrient levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]	12	1.758469e-03
GO:BP	GO:0032881	regulation of polysaccharide metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah]	5	1.805859e-03
GO:BP	GO:0070585	protein localization to mitochondrion	"A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd]	7	2.067831e-03
GO:BP	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis]	6	2.086084e-03
GO:BP	GO:0048545	response to steroid hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators]	10	2.134592e-03
GO:BP	GO:0043487	regulation of RNA stability	"Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl]	8	2.181046e-03
GO:BP	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	13	2.186265e-03
GO:BP	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	29	2.187466e-03
GO:BP	GO:1900542	regulation of purine nucleotide metabolic process	"Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie]	6	2.239421e-03
GO:BP	GO:1905710	positive regulation of membrane permeability	"Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane." [PMID:27482894]	5	2.265120e-03
GO:BP	GO:1903376	regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]	4	2.278416e-03
GO:BP	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	28	2.287556e-03
GO:BP	GO:0050684	regulation of mRNA processing	"Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]	7	2.288297e-03
GO:BP	GO:0141188	nucleic acid catabolic process	"The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators]	10	2.310906e-03
GO:BP	GO:0006163	purine nucleotide metabolic process	"The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	11	2.332654e-03
GO:BP	GO:0006140	regulation of nucleotide metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]	6	2.401856e-03
GO:BP	GO:0016070	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	49	2.414573e-03
GO:BP	GO:0043467	regulation of generation of precursor metabolites and energy	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl]	7	2.528138e-03
GO:BP	GO:0070842	aggresome assembly	"The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein." [GOC:BHF, GOC:rl, PMID:14675537]	3	2.540868e-03
GO:BP	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	10	2.565717e-03
GO:BP	GO:1905897	regulation of response to endoplasmic reticulum stress	"Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]	6	2.573800e-03
GO:BP	GO:0061013	regulation of mRNA catabolic process	"Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]	8	2.643445e-03
GO:BP	GO:0000302	response to reactive oxygen species	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc]	8	2.745313e-03
GO:BP	GO:0009150	purine ribonucleotide metabolic process	"The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	10	2.844740e-03
GO:BP	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	13	2.900861e-03
GO:BP	GO:0043434	response to peptide hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]	11	2.917410e-03
GO:BP	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	8	2.959124e-03
GO:BP	GO:0070201	regulation of establishment of protein localization	"Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]	12	3.014897e-03
GO:BP	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	8	3.071247e-03
GO:BP	GO:1903321	negative regulation of protein modification by small protein conjugation or removal	"Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	6	3.365356e-03
GO:BP	GO:2000628	regulation of miRNA metabolic process	"Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph]	6	3.365356e-03
GO:BP	GO:0036480	neuron intrinsic apoptotic signaling pathway in response to oxidative stress	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:PARL, PMID:23858059]	4	3.419078e-03
GO:BP	GO:1902369	negative regulation of RNA catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457]	6	3.591477e-03
GO:BP	GO:0032869	cellular response to insulin stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	8	3.687795e-03
GO:BP	GO:1903313	positive regulation of mRNA metabolic process	"Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	7	3.709137e-03
GO:BP	GO:0030177	positive regulation of Wnt signaling pathway	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]	7	3.709137e-03
GO:BP	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	16	3.794841e-03
GO:BP	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	35	4.007280e-03
GO:BP	GO:0032006	regulation of TOR signaling	"Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah]	7	4.067387e-03
GO:BP	GO:0044093	positive regulation of molecular function	"Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]	15	4.124666e-03
GO:BP	GO:1900151	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]	4	4.126303e-03
GO:BP	GO:0097300	programmed necrotic cell death	"A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:mtg_apoptosis, PMID:21760595]	5	4.214789e-03
GO:BP	GO:0031648	protein destabilization	"Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah]	5	4.214789e-03
GO:BP	GO:0034620	cellular response to unfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]	6	4.345407e-03
GO:BP	GO:1901874	negative regulation of post-translational protein modification	"Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]	6	4.345407e-03
GO:BP	GO:0045912	negative regulation of carbohydrate metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]	5	4.639290e-03
GO:BP	GO:0009259	ribonucleotide metabolic process	"The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	10	4.788675e-03
GO:BP	GO:1903828	negative regulation of protein localization	"Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	8	4.892900e-03
GO:BP	GO:0000271	polysaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators]	5	5.588871e-03
GO:BP	GO:0019693	ribose phosphate metabolic process	"The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]	10	5.788299e-03
GO:BP	GO:0039532	negative regulation of cytoplasmic pattern recognition receptor signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway." [GOC:bf, GOC:jl]	5	6.117629e-03
GO:BP	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	23	6.262993e-03
GO:BP	GO:1902895	positive regulation of miRNA transcription	"Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]	5	6.684916e-03
GO:BP	GO:2000737	negative regulation of stem cell differentiation	"Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol]	4	6.903165e-03
GO:BP	GO:0051086	chaperone mediated protein folding independent of cofactor	"The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb]	3	7.073396e-03
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	9	7.277616e-03
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]	9	7.277616e-03
GO:BP	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	15	7.477502e-03
GO:BP	GO:0040007	growth	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]	15	7.576163e-03
GO:BP	GO:1901654	response to ketone	"A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676]	8	7.811028e-03
GO:BP	GO:0034612	response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	8	7.811028e-03
GO:BP	GO:0044843	cell cycle G1/S phase transition	"The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle]	8	8.066499e-03
GO:BP	GO:0060544	regulation of necroptotic process	"Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]	4	8.079092e-03
GO:BP	GO:0019362	pyridine nucleotide metabolic process	"The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl]	7	8.119481e-03
GO:BP	GO:0046496	nicotinamide nucleotide metabolic process	"The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732]	7	8.119481e-03
GO:BP	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	6	8.293904e-03
GO:BP	GO:0050807	regulation of synapse organization	"Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]	9	8.309983e-03
GO:BP	GO:0051656	establishment of organelle localization	"The directed movement of an organelle to a specific location." [GOC:ai]	11	8.382960e-03
GO:BP	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	23	8.568802e-03
GO:BP	GO:0044085	cellular component biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]	39	8.595577e-03
GO:BP	GO:0009117	nucleotide metabolic process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]	11	8.714096e-03
GO:BP	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	29	9.228834e-03
GO:BP	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	6	9.254816e-03
GO:BP	GO:0062014	negative regulation of small molecule metabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]	6	9.254816e-03
GO:BP	GO:0031929	TOR signaling	"The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]	7	9.924552e-03
GO:BP	GO:0050803	regulation of synapse structure or activity	"Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]	9	9.965464e-03
GO:BP	GO:0040008	regulation of growth	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]	12	1.010853e-02
GO:BP	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	5	1.017094e-02
GO:BP	GO:1903317	regulation of protein maturation	"Any process that modulates the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	5	1.017094e-02
GO:BP	GO:1904874	positive regulation of telomerase RNA localization to Cajal body	"Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	3	1.057946e-02
GO:BP	GO:0072524	pyridine-containing compound metabolic process	"The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]	7	1.073452e-02
GO:BP	GO:0090140	regulation of mitochondrial fission	"Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	4	1.086737e-02
GO:BP	GO:0060560	developmental growth involved in morphogenesis	"The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph]	8	1.103631e-02
GO:BP	GO:0010564	regulation of cell cycle process	"Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	13	1.109235e-02
GO:BP	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]	4	1.250118e-02
GO:BP	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	7	1.252023e-02
GO:BP	GO:0060284	regulation of cell development	"Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]	14	1.278678e-02
GO:BP	GO:0046824	positive regulation of nucleocytoplasmic transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]	5	1.286142e-02
GO:BP	GO:0002683	negative regulation of immune system process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]	11	1.318666e-02
GO:BP	GO:0051085	chaperone cofactor-dependent protein refolding	"The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]	4	1.430962e-02
GO:BP	GO:0046822	regulation of nucleocytoplasmic transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]	6	1.476667e-02
GO:BP	GO:1904871	positive regulation of protein localization to Cajal body	"Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	3	1.506988e-02
GO:BP	GO:1904869	regulation of protein localization to Cajal body	"Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	3	1.506988e-02
GO:BP	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	19	1.507600e-02
GO:BP	GO:1903047	mitotic cell cycle process	"A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]	13	1.601708e-02
GO:BP	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	11	1.668057e-02
GO:BP	GO:0140694	membraneless organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081]	10	1.719807e-02
GO:BP	GO:0090559	regulation of membrane permeability	"Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane." [GOC:kmv, PMID:22677064]	5	1.728192e-02
GO:BP	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	37	1.809804e-02
GO:BP	GO:0009314	response to radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]	10	1.979457e-02
GO:BP	GO:0000380	alternative mRNA splicing, via spliceosome	"The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]	5	1.989645e-02
GO:BP	GO:0006983	ER overload response	"The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516]	3	2.066127e-02
GO:BP	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	"Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]	4	2.089926e-02
GO:BP	GO:0032774	RNA biosynthetic process	"The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]	46	2.126374e-02
GO:BP	GO:0051881	regulation of mitochondrial membrane potential	"Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]	5	2.131452e-02
GO:BP	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	7	2.156916e-02
GO:BP	GO:0032386	regulation of intracellular transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	8	2.338281e-02
GO:BP	GO:0032886	regulation of microtubule-based process	"Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah]	8	2.338281e-02
GO:BP	GO:1903578	regulation of ATP metabolic process	"Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849]	5	2.438693e-02
GO:BP	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	7	2.473468e-02
GO:BP	GO:0000725	recombinational repair	"A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh]	7	2.558347e-02
GO:BP	GO:0032868	response to insulin	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	8	2.605271e-02
GO:BP	GO:0016242	negative regulation of macroautophagy	"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]	4	2.638448e-02
GO:BP	GO:0046825	regulation of protein export from nucleus	"Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf]	4	2.638448e-02
GO:BP	GO:1903405	protein localization to nuclear body	"A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849]	3	2.746886e-02
GO:BP	GO:1904867	protein localization to Cajal body	"A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	3	2.746886e-02
GO:BP	GO:1904872	regulation of telomerase RNA localization to Cajal body	"Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	3	2.746886e-02
GO:BP	GO:1902893	regulation of miRNA transcription	"Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]	5	2.779463e-02
GO:BP	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	11	3.038992e-02
GO:BP	GO:0072521	purine-containing compound metabolic process	"The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	11	3.038992e-02
GO:BP	GO:0070925	organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	15	3.136145e-02
GO:BP	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	17	3.170142e-02
GO:BP	GO:0006403	RNA localization	"A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]	7	3.222716e-02
GO:BP	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15790595]	3	3.560647e-02
GO:BP	GO:0031571	mitotic G1 DNA damage checkpoint signaling	"A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle]	3	3.560647e-02
GO:BP	GO:2000736	regulation of stem cell differentiation	"Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol]	5	3.571794e-02
GO:BP	GO:0045913	positive regulation of carbohydrate metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]	5	3.571794e-02
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	"Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai]	7	3.662463e-02
GO:BP	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	25	3.840241e-02

source	term_id	annotation	description	intersection_size	p_value
GO:CC	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	61	2.695445e-23
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	72	7.082702e-23
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	72	7.082702e-23
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	72	7.082702e-23
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	65	8.626933e-21
GO:CC	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	64	8.685267e-20
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	68	7.347212e-19
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	68	7.414921e-19
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	40	1.249983e-16
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	40	2.069597e-16
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	40	2.104380e-16
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	40	2.104380e-16
GO:CC	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	76	5.375947e-15
GO:CC	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	34	4.655703e-12
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	47	5.529200e-12
GO:CC	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	64	4.452683e-11
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	35	1.549469e-10
GO:CC	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	22	5.810078e-10
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	40	6.641148e-10
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	77	1.757154e-09
GO:CC	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	82	3.380853e-09
GO:CC	GO:0036464	cytoplasmic ribonucleoprotein granule	"A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]	13	5.815842e-09
GO:CC	GO:0035770	ribonucleoprotein granule	"A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]	13	1.412429e-08
GO:CC	GO:0099080	supramolecular complex	"A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]	25	2.943760e-08
GO:CC	GO:0098978	glutamatergic synapse	"A synapse that uses glutamate as a neurotransmitter." [GOC:dos]	17	3.419423e-08
GO:CC	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	83	5.491779e-08
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	26	9.955399e-08
GO:CC	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	42	1.048384e-07
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	83	3.320646e-07
GO:CC	GO:1904813	ficolin-1-rich granule lumen	"Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620]	9	3.578472e-07
GO:CC	GO:0016363	nuclear matrix	"A dynamic, proteinaceous framework within the nucleus of eukaryotic cells, composed of proteins and RNA, that provides structural support for chromatin organization, gene regulation, and nuclear processes." [PMID:15608168, PMID:3058729, PMID:39789220]	9	5.088640e-07
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	31	5.996984e-07
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	31	6.350503e-07
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	84	9.947919e-07
GO:CC	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	10	2.463836e-06
GO:CC	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	14	3.558644e-06
GO:CC	GO:0016234	inclusion body	"A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]	7	3.906017e-06
GO:CC	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	22	4.620416e-06
GO:CC	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	18	4.750568e-06
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	85	5.023901e-06
GO:CC	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	30	7.795920e-06
GO:CC	GO:0101002	ficolin-1-rich granule	"Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154]	9	1.143658e-05
GO:CC	GO:0034774	secretory granule lumen	"The volume enclosed by the membrane of a secretory granule." [GOC:rph]	11	1.349389e-05
GO:CC	GO:0060205	cytoplasmic vesicle lumen	"The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles]	11	1.577507e-05
GO:CC	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	21	1.601988e-05
GO:CC	GO:0031983	vesicle lumen	"The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles]	11	1.627045e-05
GO:CC	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	7	1.835558e-05
GO:CC	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	7	2.135219e-05
GO:CC	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	7	3.070362e-05
GO:CC	GO:0016235	aggresome	"An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744]	5	6.762242e-05
GO:CC	GO:0048770	pigment granule	"A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]	7	8.692333e-05
GO:CC	GO:0042470	melanosome	"A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]	7	8.692333e-05
GO:CC	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	23	8.713346e-05
GO:CC	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	27	8.787269e-05
GO:CC	GO:0098687	chromosomal region	"Any subdivision of a chromosome along its length." [GOC:dos]	11	1.275202e-04
GO:CC	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	5	1.533090e-04
GO:CC	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640]	11	1.827075e-04
GO:CC	GO:0090734	site of DNA damage	"A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg]	7	2.016016e-04
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	11	2.150117e-04
GO:CC	GO:0099503	secretory vesicle	"A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]	17	2.389152e-04
GO:CC	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	39	2.635775e-04
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	11	2.698906e-04
GO:CC	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	15	5.177275e-04
GO:CC	GO:0044297	cell body	"The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]	12	5.325194e-04
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	15	5.540863e-04
GO:CC	GO:0099512	supramolecular fiber	"A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos]	16	8.041420e-04
GO:CC	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	11	8.700698e-04
GO:CC	GO:0099081	supramolecular polymer	"A polymeric supramolecular structure." [GOC:dos]	16	8.851415e-04
GO:CC	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917]	25	9.123202e-04
GO:CC	GO:0002199	zona pellucida receptor complex	"A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732]	3	9.297774e-04
GO:CC	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	7	1.327437e-03
GO:CC	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	59	1.328771e-03
GO:CC	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	13	1.577953e-03
GO:CC	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	8	1.968026e-03
GO:CC	GO:0005832	chaperonin-containing T-complex	"A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267]	3	1.981339e-03
GO:CC	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	13	2.513564e-03
GO:CC	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	4	2.980874e-03
GO:CC	GO:0031967	organelle envelope	"A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz]	17	3.083174e-03
GO:CC	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	5	3.187679e-03
GO:CC	GO:0099513	polymeric cytoskeletal fiber	"A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos]	13	4.450277e-03
GO:CC	GO:0035525	NF-kappaB p50/p65 complex	"A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584]	2	4.492257e-03
GO:CC	GO:1990909	Wnt signalosome	"A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]	3	4.683006e-03
GO:CC	GO:0042382	paraspeckles	"Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299]	3	4.683006e-03
GO:CC	GO:0005662	DNA replication factor A complex	"A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]	3	4.683006e-03
GO:CC	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	4	5.665141e-03
GO:CC	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	13	9.748884e-03
GO:CC	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	7	1.044165e-02
GO:CC	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	19	1.083228e-02
GO:CC	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	22	1.448331e-02
GO:CC	GO:0097225	sperm midpiece	"The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece." [GOC:cjm, MP:0009831]	4	2.108890e-02
GO:CC	GO:0043601	nuclear replisome	"A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu]	3	2.459421e-02
GO:CC	GO:0030894	replisome	"A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]	3	3.214506e-02
GO:CC	GO:0099523	presynaptic cytosol	"The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos]	3	3.642736e-02
GO:CC	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	11	4.007536e-02
GO:CC	GO:0106002	mCRD-mediated mRNA stability complex	"A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP." [GOC:bhm, PMID:11051545]	2	4.458679e-02
GO:CC	GO:0071159	NF-kappaB complex	"A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946]	2	4.458679e-02

source	term_id	annotation	description	intersection_size	p_value
HPA	HPA:0301373	Lung; alveolar cells type II[High]	Lung; alveolar cells type II[High]	35	2.992745e-20
HPA	HPA:0301372	Lung; alveolar cells type II[≥Medium]	Lung; alveolar cells type II[≥Medium]	41	5.484864e-17
HPA	HPA:0301371	Lung; alveolar cells type II[≥Low]	Lung; alveolar cells type II[≥Low]	44	3.493436e-16
HPA	HPA:0301363	Lung; alveolar cells type I[High]	Lung; alveolar cells type I[High]	28	5.919421e-16
HPA	HPA:0461411	Skin 1; cells in spinous layer[≥Low]	Skin 1; cells in spinous layer[≥Low]	32	3.301585e-15
HPA	HPA:0461461	Skin 1; langerhans cells[≥Low]	Skin 1; langerhans cells[≥Low]	31	5.809123e-15
HPA	HPA:0300203	Lung; endothelial cells[High]	Lung; endothelial cells[High]	22	9.220940e-15
HPA	HPA:0470202	Skin 2; endothelial cells[≥Medium]	Skin 2; endothelial cells[≥Medium]	29	2.318944e-14
HPA	HPA:0470672	Skin 2; melanocytes[≥Medium]	Skin 2; melanocytes[≥Medium]	29	2.630035e-14
HPA	HPA:0461442	Skin 1; fibrohistiocytic cells[≥Medium]	Skin 1; fibrohistiocytic cells[≥Medium]	30	2.912276e-14
HPA	HPA:0471472	Skin 2; lymphocytes[≥Medium]	Skin 2; lymphocytes[≥Medium]	29	3.518821e-14
HPA	HPA:0471462	Skin 2; langerhans cells[≥Medium]	Skin 2; langerhans cells[≥Medium]	29	6.488435e-14
HPA	HPA:0471461	Skin 2; langerhans cells[≥Low]	Skin 2; langerhans cells[≥Low]	31	9.108046e-14
HPA	HPA:0460673	Skin 1; melanocytes[High]	Skin 1; melanocytes[High]	34	9.937234e-14
HPA	HPA:0470182	Skin 2; cells in granular layer[≥Medium]	Skin 2; cells in granular layer[≥Medium]	27	1.000496e-13
HPA	HPA:0471471	Skin 2; lymphocytes[≥Low]	Skin 2; lymphocytes[≥Low]	31	1.441750e-13
HPA	HPA:0471412	Skin 2; cells in spinous layer[≥Medium]	Skin 2; cells in spinous layer[≥Medium]	29	1.488683e-13
HPA	HPA:0471411	Skin 2; cells in spinous layer[≥Low]	Skin 2; cells in spinous layer[≥Low]	32	1.747310e-13
HPA	HPA:0600433	Tonsil; germinal center cells[High]	Tonsil; germinal center cells[High]	37	2.227550e-13
HPA	HPA:0471392	Skin 2; cells in basal layer[≥Medium]	Skin 2; cells in basal layer[≥Medium]	30	2.403105e-13
HPA	HPA:0470201	Skin 2; endothelial cells[≥Low]	Skin 2; endothelial cells[≥Low]	32	3.046226e-13
HPA	HPA:0461412	Skin 1; cells in spinous layer[≥Medium]	Skin 1; cells in spinous layer[≥Medium]	27	3.504894e-13
HPA	HPA:0471442	Skin 2; fibrohistiocytic cells[≥Medium]	Skin 2; fibrohistiocytic cells[≥Medium]	31	4.166490e-13
HPA	HPA:0300202	Lung; endothelial cells[≥Medium]	Lung; endothelial cells[≥Medium]	28	4.168876e-13
HPA	HPA:0470181	Skin 2; cells in granular layer[≥Low]	Skin 2; cells in granular layer[≥Low]	29	6.000957e-13
HPA	HPA:0470671	Skin 2; melanocytes[≥Low]	Skin 2; melanocytes[≥Low]	29	6.942417e-13
HPA	HPA:0461472	Skin 1; lymphocytes[≥Medium]	Skin 1; lymphocytes[≥Medium]	26	1.676396e-12
HPA	HPA:0461462	Skin 1; langerhans cells[≥Medium]	Skin 1; langerhans cells[≥Medium]	26	1.898095e-12
HPA	HPA:0461391	Skin 1; cells in basal layer[≥Low]	Skin 1; cells in basal layer[≥Low]	31	1.973745e-12
HPA	HPA:0471441	Skin 2; fibrohistiocytic cells[≥Low]	Skin 2; fibrohistiocytic cells[≥Low]	33	2.193054e-12
HPA	HPA:0461392	Skin 1; cells in basal layer[≥Medium]	Skin 1; cells in basal layer[≥Medium]	27	2.230852e-12
HPA	HPA:0461441	Skin 1; fibrohistiocytic cells[≥Low]	Skin 1; fibrohistiocytic cells[≥Low]	31	2.236805e-12
HPA	HPA:0471393	Skin 2; cells in basal layer[High]	Skin 2; cells in basal layer[High]	20	2.412944e-12
HPA	HPA:0630223	Cervix; squamous epithelial cells[High]	Cervix; squamous epithelial cells[High]	33	3.351284e-12
HPA	HPA:0460202	Skin 1; endothelial cells[≥Medium]	Skin 1; endothelial cells[≥Medium]	26	3.493664e-12
HPA	HPA:0471492	Skin 2; vascular mural cells[≥Medium]	Skin 2; vascular mural cells[≥Medium]	17	3.733181e-12
HPA	HPA:0460181	Skin 1; cells in granular layer[≥Low]	Skin 1; cells in granular layer[≥Low]	28	3.776450e-12
HPA	HPA:0461471	Skin 1; lymphocytes[≥Low]	Skin 1; lymphocytes[≥Low]	28	4.054125e-12
HPA	HPA:0460201	Skin 1; endothelial cells[≥Low]	Skin 1; endothelial cells[≥Low]	30	4.415171e-12
HPA	HPA:0460182	Skin 1; cells in granular layer[≥Medium]	Skin 1; cells in granular layer[≥Medium]	25	7.880511e-12
HPA	HPA:0040083	Bone marrow; hematopoietic cells[High]	Bone marrow; hematopoietic cells[High]	38	8.068450e-12
HPA	HPA:0471473	Skin 2; lymphocytes[High]	Skin 2; lymphocytes[High]	23	8.761192e-12
HPA	HPA:0461443	Skin 1; fibrohistiocytic cells[High]	Skin 1; fibrohistiocytic cells[High]	22	9.043511e-12
HPA	HPA:0300201	Lung; endothelial cells[≥Low]	Lung; endothelial cells[≥Low]	29	9.078752e-12
HPA	HPA:0470203	Skin 2; endothelial cells[High]	Skin 2; endothelial cells[High]	20	1.066113e-11
HPA	HPA:0050052	Breast; glandular cells[≥Medium]	Breast; glandular cells[≥Medium]	68	1.111245e-11
HPA	HPA:0330223	Oral mucosa; squamous epithelial cells[High]	Oral mucosa; squamous epithelial cells[High]	34	1.114094e-11
HPA	HPA:0301361	Lung; alveolar cells type I[≥Low]	Lung; alveolar cells type I[≥Low]	33	1.493578e-11
HPA	HPA:0301362	Lung; alveolar cells type I[≥Medium]	Lung; alveolar cells type I[≥Medium]	30	1.821422e-11
HPA	HPA:0471391	Skin 2; cells in basal layer[≥Low]	Skin 2; cells in basal layer[≥Low]	31	2.199805e-11
HPA	HPA:0160251	Endometrium 1; cells in endometrial stroma[≥Low]	Endometrium 1; cells in endometrial stroma[≥Low]	61	2.822260e-11
HPA	HPA:0310432	Lymph node; germinal center cells[≥Medium]	Lymph node; germinal center cells[≥Medium]	55	3.767487e-11
HPA	HPA:0170252	Endometrium 2; cells in endometrial stroma[≥Medium]	Endometrium 2; cells in endometrial stroma[≥Medium]	41	4.488714e-11
HPA	HPA:0461473	Skin 1; lymphocytes[High]	Skin 1; lymphocytes[High]	21	5.090833e-11
HPA	HPA:0340461	Ovary; ovarian stroma cells[≥Low]	Ovary; ovarian stroma cells[≥Low]	60	5.218212e-11
HPA	HPA:0461393	Skin 1; cells in basal layer[High]	Skin 1; cells in basal layer[High]	16	5.785419e-11
HPA	HPA:0471493	Skin 2; vascular mural cells[High]	Skin 2; vascular mural cells[High]	14	5.846953e-11
HPA	HPA:0190223	Esophagus; squamous epithelial cells[High]	Esophagus; squamous epithelial cells[High]	39	8.188666e-11
HPA	HPA:0460203	Skin 1; endothelial cells[High]	Skin 1; endothelial cells[High]	19	1.023915e-10
HPA	HPA:0461493	Skin 1; vascular mural cells[High]	Skin 1; vascular mural cells[High]	14	1.105745e-10
HPA	HPA:0400652	Rectum; fibroblasts[≥Medium]	Rectum; fibroblasts[≥Medium]	13	1.157703e-10
HPA	HPA:0530721	Spleen; cells in white pulp[≥Low]	Spleen; cells in white pulp[≥Low]	62	1.192489e-10
HPA	HPA:0471443	Skin 2; fibrohistiocytic cells[High]	Skin 2; fibrohistiocytic cells[High]	22	1.420720e-10
HPA	HPA:0471491	Skin 2; vascular mural cells[≥Low]	Skin 2; vascular mural cells[≥Low]	17	1.490169e-10
HPA	HPA:0510653	Soft tissue 2; fibroblasts[High]	Soft tissue 2; fibroblasts[High]	23	1.527264e-10
HPA	HPA:0340462	Ovary; ovarian stroma cells[≥Medium]	Ovary; ovarian stroma cells[≥Medium]	43	1.673670e-10
HPA	HPA:0461413	Skin 1; cells in spinous layer[High]	Skin 1; cells in spinous layer[High]	16	2.023473e-10
HPA	HPA:0600432	Tonsil; germinal center cells[≥Medium]	Tonsil; germinal center cells[≥Medium]	60	2.183509e-10
HPA	HPA:0310431	Lymph node; germinal center cells[≥Low]	Lymph node; germinal center cells[≥Low]	66	3.145809e-10
HPA	HPA:0620223	Vagina; squamous epithelial cells[High]	Vagina; squamous epithelial cells[High]	32	3.369455e-10
HPA	HPA:0461463	Skin 1; langerhans cells[High]	Skin 1; langerhans cells[High]	16	4.502360e-10
HPA	HPA:0400651	Rectum; fibroblasts[≥Low]	Rectum; fibroblasts[≥Low]	13	5.713649e-10
HPA	HPA:0170251	Endometrium 2; cells in endometrial stroma[≥Low]	Endometrium 2; cells in endometrial stroma[≥Low]	55	6.721750e-10
HPA	HPA:0461492	Skin 1; vascular mural cells[≥Medium]	Skin 1; vascular mural cells[≥Medium]	15	7.736062e-10
HPA	HPA:0471463	Skin 2; langerhans cells[High]	Skin 2; langerhans cells[High]	17	7.895861e-10
HPA	HPA:0470673	Skin 2; melanocytes[High]	Skin 2; melanocytes[High]	19	8.514277e-10
HPA	HPA:0510652	Soft tissue 2; fibroblasts[≥Medium]	Soft tissue 2; fibroblasts[≥Medium]	47	1.389191e-09
HPA	HPA:0600223	Tonsil; squamous epithelial cells[High]	Tonsil; squamous epithelial cells[High]	35	2.290588e-09
HPA	HPA:0160053	Endometrium 1; glandular cells[High]	Endometrium 1; glandular cells[High]	35	2.336188e-09
HPA	HPA:0500653	Soft tissue 1; fibroblasts[High]	Soft tissue 1; fibroblasts[High]	22	2.677699e-09
HPA	HPA:0340000	Ovary	Ovary	67	3.003564e-09
HPA	HPA:0600431	Tonsil; germinal center cells[≥Low]	Tonsil; germinal center cells[≥Low]	70	3.207852e-09
HPA	HPA:0570812	Testis; spermatogonia cells[≥Medium]	Testis; spermatogonia cells[≥Medium]	46	3.394253e-09
HPA	HPA:0510703	Soft tissue 2; peripheral nerve[High]	Soft tissue 2; peripheral nerve[High]	17	3.712281e-09
HPA	HPA:0310433	Lymph node; germinal center cells[High]	Lymph node; germinal center cells[High]	28	3.962413e-09
HPA	HPA:0570773	Testis; peritubular cells[High]	Testis; peritubular cells[High]	15	5.686213e-09
HPA	HPA:0050053	Breast; glandular cells[High]	Breast; glandular cells[High]	33	6.032643e-09
HPA	HPA:0400202	Rectum; endothelial cells[≥Medium]	Rectum; endothelial cells[≥Medium]	14	8.392841e-09
HPA	HPA:0050093	Breast; myoepithelial cells[High]	Breast; myoepithelial cells[High]	26	9.961478e-09
HPA	HPA:0180053	Epididymis; glandular cells[High]	Epididymis; glandular cells[High]	38	1.377026e-08
HPA	HPA:0210053	Fallopian tube; glandular cells[High]	Fallopian tube; glandular cells[High]	36	1.382955e-08
HPA	HPA:0050012	Breast; adipocytes[≥Medium]	Breast; adipocytes[≥Medium]	34	1.705271e-08
HPA	HPA:0340463	Ovary; ovarian stroma cells[High]	Ovary; ovarian stroma cells[High]	18	2.284088e-08
HPA	HPA:0050051	Breast; glandular cells[≥Low]	Breast; glandular cells[≥Low]	73	2.314903e-08
HPA	HPA:0170053	Endometrium 2; glandular cells[High]	Endometrium 2; glandular cells[High]	32	2.332876e-08
HPA	HPA:0570811	Testis; spermatogonia cells[≥Low]	Testis; spermatogonia cells[≥Low]	49	2.575776e-08
HPA	HPA:0461491	Skin 1; vascular mural cells[≥Low]	Skin 1; vascular mural cells[≥Low]	15	2.682075e-08
HPA	HPA:0471413	Skin 2; cells in spinous layer[High]	Skin 2; cells in spinous layer[High]	15	3.788813e-08
HPA	HPA:0380513	Placenta; decidual cells[High]	Placenta; decidual cells[High]	30	5.013433e-08
HPA	HPA:0170052	Endometrium 2; glandular cells[≥Medium]	Endometrium 2; glandular cells[≥Medium]	62	5.067207e-08
HPA	HPA:0400201	Rectum; endothelial cells[≥Low]	Rectum; endothelial cells[≥Low]	15	5.302579e-08
HPA	HPA:0190222	Esophagus; squamous epithelial cells[≥Medium]	Esophagus; squamous epithelial cells[≥Medium]	63	5.633745e-08
HPA	HPA:0430053	Seminal vesicle; glandular cells[High]	Seminal vesicle; glandular cells[High]	33	6.244671e-08
HPA	HPA:0610833	Urinary bladder; urothelial cells[High]	Urinary bladder; urothelial cells[High]	39	6.366211e-08
HPA	HPA:0630000	Cervix	Cervix	73	6.741008e-08
HPA	HPA:0090193	Cerebellum; cells in molecular layer[High]	Cerebellum; cells in molecular layer[High]	26	7.859177e-08
HPA	HPA:0030442	Appendix; non-germinal center cells[≥Medium]	Appendix; non-germinal center cells[≥Medium]	15	8.187834e-08
HPA	HPA:0170253	Endometrium 2; cells in endometrial stroma[High]	Endometrium 2; cells in endometrial stroma[High]	17	8.611536e-08
HPA	HPA:0600222	Tonsil; squamous epithelial cells[≥Medium]	Tonsil; squamous epithelial cells[≥Medium]	62	8.863049e-08
HPA	HPA:0050000	Breast	Breast	74	8.925887e-08
HPA	HPA:0291162	Liver; cholangiocytes[≥Medium]	Liver; cholangiocytes[≥Medium]	38	9.185875e-08
HPA	HPA:0330222	Oral mucosa; squamous epithelial cells[≥Medium]	Oral mucosa; squamous epithelial cells[≥Medium]	58	1.006612e-07
HPA	HPA:0390053	Prostate; glandular cells[High]	Prostate; glandular cells[High]	31	1.209225e-07
HPA	HPA:0460671	Skin 1; melanocytes[≥Low]	Skin 1; melanocytes[≥Low]	64	1.276985e-07
HPA	HPA:0291161	Liver; cholangiocytes[≥Low]	Liver; cholangiocytes[≥Low]	55	1.281687e-07
HPA	HPA:0630053	Cervix; glandular cells[High]	Cervix; glandular cells[High]	29	1.505581e-07
HPA	HPA:0351183	Pancreas; pancreatic endocrine cells[High]	Pancreas; pancreatic endocrine cells[High]	24	1.550638e-07
HPA	HPA:0180052	Epididymis; glandular cells[≥Medium]	Epididymis; glandular cells[≥Medium]	66	2.129146e-07
HPA	HPA:0160000	Endometrium 1	Endometrium 1	73	2.307223e-07
HPA	HPA:0060103	Bronchus; respiratory epithelial cells[High]	Bronchus; respiratory epithelial cells[High]	36	2.446424e-07
HPA	HPA:0570783	Testis; preleptotene spermatocytes[High]	Testis; preleptotene spermatocytes[High]	23	2.497657e-07
HPA	HPA:0080123	Caudate; glial cells[High]	Caudate; glial cells[High]	22	2.546381e-07
HPA	HPA:0610000	Urinary bladder	Urinary bladder	74	2.616395e-07
HPA	HPA:0610831	Urinary bladder; urothelial cells[≥Low]	Urinary bladder; urothelial cells[≥Low]	74	2.616395e-07
HPA	HPA:0330000	Oral mucosa	Oral mucosa	69	2.727469e-07
HPA	HPA:0330221	Oral mucosa; squamous epithelial cells[≥Low]	Oral mucosa; squamous epithelial cells[≥Low]	69	2.727469e-07
HPA	HPA:0600221	Tonsil; squamous epithelial cells[≥Low]	Tonsil; squamous epithelial cells[≥Low]	71	2.735099e-07
HPA	HPA:0090191	Cerebellum; cells in molecular layer[≥Low]	Cerebellum; cells in molecular layer[≥Low]	58	2.741269e-07
HPA	HPA:0570813	Testis; spermatogonia cells[High]	Testis; spermatogonia cells[High]	32	2.787374e-07
HPA	HPA:0030441	Appendix; non-germinal center cells[≥Low]	Appendix; non-germinal center cells[≥Low]	16	2.820140e-07
HPA	HPA:0050092	Breast; myoepithelial cells[≥Medium]	Breast; myoepithelial cells[≥Medium]	53	2.959359e-07
HPA	HPA:0100121	Cerebral cortex; glial cells[≥Low]	Cerebral cortex; glial cells[≥Low]	61	3.428901e-07
HPA	HPA:0190221	Esophagus; squamous epithelial cells[≥Low]	Esophagus; squamous epithelial cells[≥Low]	71	3.569423e-07
HPA	HPA:0190000	Esophagus	Esophagus	71	3.569423e-07
HPA	HPA:0470183	Skin 2; cells in granular layer[High]	Skin 2; cells in granular layer[High]	14	4.087693e-07
HPA	HPA:0460183	Skin 1; cells in granular layer[High]	Skin 1; cells in granular layer[High]	14	4.087693e-07
HPA	HPA:0010011	Adipose tissue; adipocytes[≥Low]	Adipose tissue; adipocytes[≥Low]	54	4.219291e-07
HPA	HPA:0010000	Adipose tissue	Adipose tissue	54	4.219291e-07
HPA	HPA:0600441	Tonsil; non-germinal center cells[≥Low]	Tonsil; non-germinal center cells[≥Low]	68	4.516270e-07
HPA	HPA:0170000	Endometrium 2	Endometrium 2	72	4.759799e-07
HPA	HPA:0600443	Tonsil; non-germinal center cells[High]	Tonsil; non-germinal center cells[High]	30	4.779654e-07
HPA	HPA:0590053	Thyroid gland; glandular cells[High]	Thyroid gland; glandular cells[High]	36	5.224595e-07
HPA	HPA:0010013	Adipose tissue; adipocytes[High]	Adipose tissue; adipocytes[High]	18	5.254192e-07
HPA	HPA:0360052	Parathyroid gland; glandular cells[≥Medium]	Parathyroid gland; glandular cells[≥Medium]	57	7.138022e-07
HPA	HPA:0130651	Colon; fibroblasts[≥Low]	Colon; fibroblasts[≥Low]	10	7.753425e-07
HPA	HPA:0080122	Caudate; glial cells[≥Medium]	Caudate; glial cells[≥Medium]	40	7.773108e-07
HPA	HPA:0050013	Breast; adipocytes[High]	Breast; adipocytes[High]	15	8.367878e-07
HPA	HPA:0320000	Nasopharynx	Nasopharynx	73	8.524586e-07
HPA	HPA:0440343	Skeletal muscle; myocytes[High]	Skeletal muscle; myocytes[High]	24	9.135062e-07
HPA	HPA:0050011	Breast; adipocytes[≥Low]	Breast; adipocytes[≥Low]	44	1.005565e-06
HPA	HPA:0160252	Endometrium 1; cells in endometrial stroma[≥Medium]	Endometrium 1; cells in endometrial stroma[≥Medium]	39	1.046167e-06
HPA	HPA:0510000	Soft tissue 2	Soft tissue 2	62	1.105551e-06
HPA	HPA:0400000	Rectum	Rectum	76	1.124689e-06
HPA	HPA:0090192	Cerebellum; cells in molecular layer[≥Medium]	Cerebellum; cells in molecular layer[≥Medium]	44	1.160520e-06
HPA	HPA:0620222	Vagina; squamous epithelial cells[≥Medium]	Vagina; squamous epithelial cells[≥Medium]	54	1.272277e-06
HPA	HPA:0310443	Lymph node; non-germinal center cells[High]	Lymph node; non-germinal center cells[High]	28	1.319483e-06
HPA	HPA:0470000	Skin 2	Skin 2	72	1.334700e-06
HPA	HPA:0360051	Parathyroid gland; glandular cells[≥Low]	Parathyroid gland; glandular cells[≥Low]	66	1.408328e-06
HPA	HPA:0360000	Parathyroid gland	Parathyroid gland	66	1.408328e-06
HPA	HPA:0160253	Endometrium 1; cells in endometrial stroma[High]	Endometrium 1; cells in endometrial stroma[High]	17	1.670489e-06
HPA	HPA:0131302	Colon; enterocytes[≥Medium]	Colon; enterocytes[≥Medium]	16	1.732022e-06
HPA	HPA:0530722	Spleen; cells in white pulp[≥Medium]	Spleen; cells in white pulp[≥Medium]	43	1.955384e-06
HPA	HPA:0460672	Skin 1; melanocytes[≥Medium]	Skin 1; melanocytes[≥Medium]	51	2.242218e-06
HPA	HPA:0401302	Rectum; enterocytes[≥Medium]	Rectum; enterocytes[≥Medium]	16	2.245664e-06
HPA	HPA:0320103	Nasopharynx; respiratory epithelial cells[High]	Nasopharynx; respiratory epithelial cells[High]	34	2.302425e-06
HPA	HPA:0610832	Urinary bladder; urothelial cells[≥Medium]	Urinary bladder; urothelial cells[≥Medium]	66	2.474161e-06
HPA	HPA:0630221	Cervix; squamous epithelial cells[≥Low]	Cervix; squamous epithelial cells[≥Low]	63	2.509529e-06
HPA	HPA:0351181	Pancreas; pancreatic endocrine cells[≥Low]	Pancreas; pancreatic endocrine cells[≥Low]	64	2.610078e-06
HPA	HPA:0131333	Colon; mucosal lymphoid cells[High]	Colon; mucosal lymphoid cells[High]	11	2.667287e-06
HPA	HPA:0510651	Soft tissue 2; fibroblasts[≥Low]	Soft tissue 2; fibroblasts[≥Low]	54	2.767373e-06
HPA	HPA:0500703	Soft tissue 1; peripheral nerve[High]	Soft tissue 1; peripheral nerve[High]	13	2.868184e-06
HPA	HPA:0270353	Kidney; cells in glomeruli[High]	Kidney; cells in glomeruli[High]	23	2.887536e-06
HPA	HPA:0630222	Cervix; squamous epithelial cells[≥Medium]	Cervix; squamous epithelial cells[≥Medium]	51	2.896903e-06
HPA	HPA:0400653	Rectum; fibroblasts[High]	Rectum; fibroblasts[High]	8	2.965705e-06
HPA	HPA:0130243	Colon; peripheral nerve/ganglion[High]	Colon; peripheral nerve/ganglion[High]	23	3.018275e-06
HPA	HPA:0461453	Skin 1; hair follicles[High]	Skin 1; hair follicles[High]	10	3.064091e-06
HPA	HPA:0310000	Lymph node	Lymph node	69	3.149097e-06
HPA	HPA:0170051	Endometrium 2; glandular cells[≥Low]	Endometrium 2; glandular cells[≥Low]	70	3.187299e-06
HPA	HPA:0030000	Appendix	Appendix	75	3.398793e-06
HPA	HPA:0481303	Small intestine; enterocytes[High]	Small intestine; enterocytes[High]	13	3.493234e-06
HPA	HPA:0620221	Vagina; squamous epithelial cells[≥Low]	Vagina; squamous epithelial cells[≥Low]	66	3.647332e-06
HPA	HPA:0620000	Vagina	Vagina	66	3.647332e-06
HPA	HPA:0570771	Testis; peritubular cells[≥Low]	Testis; peritubular cells[≥Low]	21	4.187595e-06
HPA	HPA:0570772	Testis; peritubular cells[≥Medium]	Testis; peritubular cells[≥Medium]	18	4.449222e-06
HPA	HPA:0100122	Cerebral cortex; glial cells[≥Medium]	Cerebral cortex; glial cells[≥Medium]	42	4.673280e-06
HPA	HPA:0090000	Cerebellum	Cerebellum	72	5.476019e-06
HPA	HPA:0100133	Cerebral cortex; neuronal cells[High]	Cerebral cortex; neuronal cells[High]	34	5.584229e-06
HPA	HPA:0060000	Bronchus	Bronchus	73	6.601599e-06
HPA	HPA:0130242	Colon; peripheral nerve/ganglion[≥Medium]	Colon; peripheral nerve/ganglion[≥Medium]	48	6.655864e-06
HPA	HPA:0420053	Salivary gland; glandular cells[High]	Salivary gland; glandular cells[High]	30	6.736297e-06
HPA	HPA:0530000	Spleen	Spleen	65	6.824535e-06
HPA	HPA:0160051	Endometrium 1; glandular cells[≥Low]	Endometrium 1; glandular cells[≥Low]	70	7.151992e-06
HPA	HPA:0500652	Soft tissue 1; fibroblasts[≥Medium]	Soft tissue 1; fibroblasts[≥Medium]	42	7.747369e-06
HPA	HPA:0210000	Fallopian tube	Fallopian tube	73	8.744856e-06
HPA	HPA:0400203	Rectum; endothelial cells[High]	Rectum; endothelial cells[High]	9	9.009810e-06
HPA	HPA:0250123	Hippocampus; glial cells[High]	Hippocampus; glial cells[High]	18	9.610294e-06
HPA	HPA:0401333	Rectum; mucosal lymphoid cells[High]	Rectum; mucosal lymphoid cells[High]	11	9.928992e-06
HPA	HPA:0040081	Bone marrow; hematopoietic cells[≥Low]	Bone marrow; hematopoietic cells[≥Low]	68	1.194127e-05
HPA	HPA:0040000	Bone marrow	Bone marrow	68	1.194127e-05
HPA	HPA:0380000	Placenta	Placenta	73	1.290108e-05
HPA	HPA:0250133	Hippocampus; neuronal cells[High]	Hippocampus; neuronal cells[High]	27	1.377415e-05
HPA	HPA:0010012	Adipose tissue; adipocytes[≥Medium]	Adipose tissue; adipocytes[≥Medium]	37	1.562998e-05
HPA	HPA:0540052	Stomach 1; glandular cells[≥Medium]	Stomach 1; glandular cells[≥Medium]	67	1.582436e-05
HPA	HPA:0300412	Lung; macrophages[≥Medium]	Lung; macrophages[≥Medium]	58	1.708633e-05
HPA	HPA:0590000	Thyroid gland	Thyroid gland	71	1.734259e-05
HPA	HPA:0590051	Thyroid gland; glandular cells[≥Low]	Thyroid gland; glandular cells[≥Low]	71	1.734259e-05
HPA	HPA:0180051	Epididymis; glandular cells[≥Low]	Epididymis; glandular cells[≥Low]	72	1.786010e-05
HPA	HPA:0180000	Epididymis	Epididymis	72	1.786010e-05
HPA	HPA:0600000	Tonsil	Tonsil	74	1.892786e-05
HPA	HPA:0130892	Colon; goblet cells[≥Medium]	Colon; goblet cells[≥Medium]	14	1.945933e-05
HPA	HPA:0300413	Lung; macrophages[High]	Lung; macrophages[High]	28	2.051239e-05
HPA	HPA:0400242	Rectum; peripheral nerve/ganglion[≥Medium]	Rectum; peripheral nerve/ganglion[≥Medium]	11	2.289199e-05
HPA	HPA:0480892	Small intestine; goblet cells[≥Medium]	Small intestine; goblet cells[≥Medium]	14	2.336908e-05
HPA	HPA:0250132	Hippocampus; neuronal cells[≥Medium]	Hippocampus; neuronal cells[≥Medium]	53	2.592349e-05
HPA	HPA:0131292	Colon; endocrine cells[≥Medium]	Colon; endocrine cells[≥Medium]	15	2.605972e-05
HPA	HPA:0300411	Lung; macrophages[≥Low]	Lung; macrophages[≥Low]	69	2.608853e-05
HPA	HPA:0130000	Colon	Colon	76	2.707546e-05
HPA	HPA:0500651	Soft tissue 1; fibroblasts[≥Low]	Soft tissue 1; fibroblasts[≥Low]	53	2.812696e-05
HPA	HPA:0401292	Rectum; endocrine cells[≥Medium]	Rectum; endocrine cells[≥Medium]	15	2.872052e-05
HPA	HPA:0390052	Prostate; glandular cells[≥Medium]	Prostate; glandular cells[≥Medium]	57	2.894709e-05
HPA	HPA:0270352	Kidney; cells in glomeruli[≥Medium]	Kidney; cells in glomeruli[≥Medium]	44	3.082193e-05
HPA	HPA:0130653	Colon; fibroblasts[High]	Colon; fibroblasts[High]	7	3.225489e-05
HPA	HPA:0020051	Adrenal gland; glandular cells[≥Low]	Adrenal gland; glandular cells[≥Low]	72	3.317105e-05
HPA	HPA:0570803	Testis; sertoli cells[High]	Testis; sertoli cells[High]	18	3.479213e-05
HPA	HPA:0020000	Adrenal gland	Adrenal gland	72	3.512660e-05
HPA	HPA:0310442	Lymph node; non-germinal center cells[≥Medium]	Lymph node; non-germinal center cells[≥Medium]	51	3.515912e-05
HPA	HPA:0040082	Bone marrow; hematopoietic cells[≥Medium]	Bone marrow; hematopoietic cells[≥Medium]	53	3.522862e-05
HPA	HPA:0570801	Testis; sertoli cells[≥Low]	Testis; sertoli cells[≥Low]	39	4.165071e-05
HPA	HPA:0350472	Pancreas; exocrine glandular cells[≥Medium]	Pancreas; exocrine glandular cells[≥Medium]	60	4.202735e-05
HPA	HPA:0550053	Stomach 2; glandular cells[High]	Stomach 2; glandular cells[High]	38	4.243650e-05
HPA	HPA:0031301	Appendix; enterocytes[≥Low]	Appendix; enterocytes[≥Low]	16	4.252804e-05
HPA	HPA:0290000	Liver	Liver	66	4.324148e-05
HPA	HPA:0130893	Colon; goblet cells[High]	Colon; goblet cells[High]	11	4.455945e-05
HPA	HPA:0150000	Duodenum	Duodenum	74	4.713355e-05
HPA	HPA:0031302	Appendix; enterocytes[≥Medium]	Appendix; enterocytes[≥Medium]	14	4.877226e-05
HPA	HPA:0080121	Caudate; glial cells[≥Low]	Caudate; glial cells[≥Low]	55	4.892716e-05
HPA	HPA:0480893	Small intestine; goblet cells[High]	Small intestine; goblet cells[High]	11	4.915609e-05
HPA	HPA:0490693	Smooth muscle; smooth muscle cells[High]	Smooth muscle; smooth muscle cells[High]	18	5.404419e-05
HPA	HPA:0131332	Colon; mucosal lymphoid cells[≥Medium]	Colon; mucosal lymphoid cells[≥Medium]	14	5.578822e-05
HPA	HPA:0530711	Spleen; cells in red pulp[≥Low]	Spleen; cells in red pulp[≥Low]	60	5.668381e-05
HPA	HPA:0031292	Appendix; endocrine cells[≥Medium]	Appendix; endocrine cells[≥Medium]	14	5.962703e-05
HPA	HPA:0400241	Rectum; peripheral nerve/ganglion[≥Low]	Rectum; peripheral nerve/ganglion[≥Low]	12	6.077463e-05
HPA	HPA:0400893	Rectum; goblet cells[High]	Rectum; goblet cells[High]	11	6.253728e-05
HPA	HPA:0030892	Appendix; goblet cells[≥Medium]	Appendix; goblet cells[≥Medium]	13	6.426378e-05
HPA	HPA:0130201	Colon; endothelial cells[≥Low]	Colon; endothelial cells[≥Low]	62	6.649498e-05
HPA	HPA:0420000	Salivary gland	Salivary gland	69	6.887105e-05
HPA	HPA:0420051	Salivary gland; glandular cells[≥Low]	Salivary gland; glandular cells[≥Low]	69	6.887105e-05
HPA	HPA:0500000	Soft tissue 1	Soft tissue 1	60	6.963247e-05
HPA	HPA:0130203	Colon; endothelial cells[High]	Colon; endothelial cells[High]	21	7.079903e-05
HPA	HPA:0131303	Colon; enterocytes[High]	Colon; enterocytes[High]	11	7.905118e-05
HPA	HPA:0500113	Soft tissue 1; chondrocytes[High]	Soft tissue 1; chondrocytes[High]	13	8.276281e-05
HPA	HPA:0130652	Colon; fibroblasts[≥Medium]	Colon; fibroblasts[≥Medium]	8	8.417828e-05
HPA	HPA:0430052	Seminal vesicle; glandular cells[≥Medium]	Seminal vesicle; glandular cells[≥Medium]	59	8.455132e-05
HPA	HPA:0291163	Liver; cholangiocytes[High]	Liver; cholangiocytes[High]	13	8.576295e-05
HPA	HPA:0481302	Small intestine; enterocytes[≥Medium]	Small intestine; enterocytes[≥Medium]	15	8.909854e-05
HPA	HPA:0131301	Colon; enterocytes[≥Low]	Colon; enterocytes[≥Low]	16	8.953641e-05
HPA	HPA:0350473	Pancreas; exocrine glandular cells[High]	Pancreas; exocrine glandular cells[High]	33	8.982455e-05
HPA	HPA:0570763	Testis; pachytene spermatocytes[High]	Testis; pachytene spermatocytes[High]	22	9.485556e-05
HPA	HPA:0020053	Adrenal gland; glandular cells[High]	Adrenal gland; glandular cells[High]	36	9.874052e-05
HPA	HPA:0250131	Hippocampus; neuronal cells[≥Low]	Hippocampus; neuronal cells[≥Low]	65	9.877673e-05
HPA	HPA:0131291	Colon; endocrine cells[≥Low]	Colon; endocrine cells[≥Low]	15	1.000053e-04
HPA	HPA:0131331	Colon; mucosal lymphoid cells[≥Low]	Colon; mucosal lymphoid cells[≥Low]	16	1.022226e-04
HPA	HPA:0310441	Lymph node; non-germinal center cells[≥Low]	Lymph node; non-germinal center cells[≥Low]	64	1.064160e-04
HPA	HPA:0401301	Rectum; enterocytes[≥Low]	Rectum; enterocytes[≥Low]	16	1.105968e-04
HPA	HPA:0080000	Caudate	Caudate	69	1.142583e-04
HPA	HPA:0401291	Rectum; endocrine cells[≥Low]	Rectum; endocrine cells[≥Low]	15	1.153312e-04
HPA	HPA:0570782	Testis; preleptotene spermatocytes[≥Medium]	Testis; preleptotene spermatocytes[≥Medium]	28	1.193379e-04
HPA	HPA:0220053	Gallbladder; glandular cells[High]	Gallbladder; glandular cells[High]	41	1.237966e-04
HPA	HPA:0401303	Rectum; enterocytes[High]	Rectum; enterocytes[High]	11	1.240458e-04
HPA	HPA:0300000	Lung	Lung	71	1.277545e-04
HPA	HPA:0250121	Hippocampus; glial cells[≥Low]	Hippocampus; glial cells[≥Low]	51	1.406969e-04
HPA	HPA:0481292	Small intestine; endocrine cells[≥Medium]	Small intestine; endocrine cells[≥Medium]	15	1.483618e-04
HPA	HPA:0250122	Hippocampus; glial cells[≥Medium]	Hippocampus; glial cells[≥Medium]	33	1.524400e-04
HPA	HPA:0401332	Rectum; mucosal lymphoid cells[≥Medium]	Rectum; mucosal lymphoid cells[≥Medium]	14	1.587545e-04
HPA	HPA:0430051	Seminal vesicle; glandular cells[≥Low]	Seminal vesicle; glandular cells[≥Low]	68	1.673624e-04
HPA	HPA:0430000	Seminal vesicle	Seminal vesicle	68	1.673624e-04
HPA	HPA:0270351	Kidney; cells in glomeruli[≥Low]	Kidney; cells in glomeruli[≥Low]	58	1.689485e-04
HPA	HPA:0250000	Hippocampus	Hippocampus	68	1.699740e-04
HPA	HPA:0100123	Cerebral cortex; glial cells[High]	Cerebral cortex; glial cells[High]	19	1.723007e-04
HPA	HPA:0481293	Small intestine; endocrine cells[High]	Small intestine; endocrine cells[High]	12	1.750888e-04
HPA	HPA:0400892	Rectum; goblet cells[≥Medium]	Rectum; goblet cells[≥Medium]	13	1.759888e-04
HPA	HPA:0031303	Appendix; enterocytes[High]	Appendix; enterocytes[High]	10	1.912793e-04
HPA	HPA:0050091	Breast; myoepithelial cells[≥Low]	Breast; myoepithelial cells[≥Low]	61	2.086583e-04
HPA	HPA:0151301	Duodenum; enterocytes[≥Low]	Duodenum; enterocytes[≥Low]	16	2.138423e-04
HPA	HPA:0461452	Skin 1; hair follicles[≥Medium]	Skin 1; hair follicles[≥Medium]	12	2.180231e-04
HPA	HPA:0460000	Skin 1	Skin 1	70	2.185898e-04
HPA	HPA:0480891	Small intestine; goblet cells[≥Low]	Small intestine; goblet cells[≥Low]	14	2.198620e-04
HPA	HPA:0400891	Rectum; goblet cells[≥Low]	Rectum; goblet cells[≥Low]	14	2.198620e-04
HPA	HPA:0600442	Tonsil; non-germinal center cells[≥Medium]	Tonsil; non-germinal center cells[≥Medium]	51	2.285296e-04
HPA	HPA:0500702	Soft tissue 1; peripheral nerve[≥Medium]	Soft tissue 1; peripheral nerve[≥Medium]	26	2.316835e-04
HPA	HPA:0130891	Colon; goblet cells[≥Low]	Colon; goblet cells[≥Low]	14	2.330070e-04
HPA	HPA:0241103	Heart muscle; cardiomyocytes[High]	Heart muscle; cardiomyocytes[High]	24	2.380042e-04
HPA	HPA:0401331	Rectum; mucosal lymphoid cells[≥Low]	Rectum; mucosal lymphoid cells[≥Low]	16	2.416523e-04
HPA	HPA:0100000	Cerebral cortex	Cerebral cortex	74	2.433909e-04
HPA	HPA:0540051	Stomach 1; glandular cells[≥Low]	Stomach 1; glandular cells[≥Low]	72	2.434001e-04
HPA	HPA:0540000	Stomach 1	Stomach 1	72	2.434001e-04
HPA	HPA:0510702	Soft tissue 2; peripheral nerve[≥Medium]	Soft tissue 2; peripheral nerve[≥Medium]	28	2.456258e-04
HPA	HPA:0100201	Cerebral cortex; endothelial cells[≥Low]	Cerebral cortex; endothelial cells[≥Low]	54	2.534573e-04
HPA	HPA:0031291	Appendix; endocrine cells[≥Low]	Appendix; endocrine cells[≥Low]	14	2.847574e-04
HPA	HPA:0400243	Rectum; peripheral nerve/ganglion[High]	Rectum; peripheral nerve/ganglion[High]	8	2.949359e-04
HPA	HPA:0131293	Colon; endocrine cells[High]	Colon; endocrine cells[High]	11	3.221729e-04
HPA	HPA:0151291	Duodenum; endocrine cells[≥Low]	Duodenum; endocrine cells[≥Low]	15	3.555527e-04
HPA	HPA:0151302	Duodenum; enterocytes[≥Medium]	Duodenum; enterocytes[≥Medium]	14	3.563492e-04
HPA	HPA:0090161	Cerebellum; Purkinje cells[≥Low]	Cerebellum; Purkinje cells[≥Low]	60	3.594971e-04
HPA	HPA:0210052	Fallopian tube; glandular cells[≥Medium]	Fallopian tube; glandular cells[≥Medium]	54	3.612791e-04
HPA	HPA:0481291	Small intestine; endocrine cells[≥Low]	Small intestine; endocrine cells[≥Low]	15	3.646795e-04
HPA	HPA:0461451	Skin 1; hair follicles[≥Low]	Skin 1; hair follicles[≥Low]	13	3.762267e-04
HPA	HPA:0570793	Testis; round or early spermatids[High]	Testis; round or early spermatids[High]	22	3.823548e-04
HPA	HPA:0350471	Pancreas; exocrine glandular cells[≥Low]	Pancreas; exocrine glandular cells[≥Low]	68	4.024598e-04
HPA	HPA:0100132	Cerebral cortex; neuronal cells[≥Medium]	Cerebral cortex; neuronal cells[≥Medium]	56	4.298316e-04
HPA	HPA:0150893	Duodenum; goblet cells[High]	Duodenum; goblet cells[High]	10	4.381931e-04
HPA	HPA:0481301	Small intestine; enterocytes[≥Low]	Small intestine; enterocytes[≥Low]	16	4.567690e-04
HPA	HPA:0351182	Pancreas; pancreatic endocrine cells[≥Medium]	Pancreas; pancreatic endocrine cells[≥Medium]	46	4.611597e-04
HPA	HPA:0570781	Testis; preleptotene spermatocytes[≥Low]	Testis; preleptotene spermatocytes[≥Low]	31	5.060959e-04
HPA	HPA:0220052	Gallbladder; glandular cells[≥Medium]	Gallbladder; glandular cells[≥Medium]	66	5.086229e-04
HPA	HPA:0550052	Stomach 2; glandular cells[≥Medium]	Stomach 2; glandular cells[≥Medium]	64	5.617913e-04
HPA	HPA:0570792	Testis; round or early spermatids[≥Medium]	Testis; round or early spermatids[≥Medium]	31	5.808160e-04
HPA	HPA:0540053	Stomach 1; glandular cells[High]	Stomach 1; glandular cells[High]	36	5.931094e-04
HPA	HPA:0320102	Nasopharynx; respiratory epithelial cells[≥Medium]	Nasopharynx; respiratory epithelial cells[≥Medium]	54	6.224781e-04
HPA	HPA:0401293	Rectum; endocrine cells[High]	Rectum; endocrine cells[High]	11	6.346875e-04
HPA	HPA:0030891	Appendix; goblet cells[≥Low]	Appendix; goblet cells[≥Low]	13	6.401569e-04
HPA	HPA:0270000	Kidney	Kidney	74	6.595217e-04
HPA	HPA:0340452	Ovary; follicle cells[≥Medium]	Ovary; follicle cells[≥Medium]	34	7.036791e-04
HPA	HPA:0530713	Spleen; cells in red pulp[High]	Spleen; cells in red pulp[High]	19	7.390319e-04
HPA	HPA:0570000	Testis	Testis	77	7.446180e-04
HPA	HPA:0350000	Pancreas	Pancreas	70	7.490922e-04
HPA	HPA:0390000	Prostate	Prostate	66	7.977089e-04
HPA	HPA:0390051	Prostate; glandular cells[≥Low]	Prostate; glandular cells[≥Low]	66	7.977089e-04
HPA	HPA:0630051	Cervix; glandular cells[≥Low]	Cervix; glandular cells[≥Low]	60	8.796360e-04
HPA	HPA:0150892	Duodenum; goblet cells[≥Medium]	Duodenum; goblet cells[≥Medium]	12	8.836913e-04
HPA	HPA:0020052	Adrenal gland; glandular cells[≥Medium]	Adrenal gland; glandular cells[≥Medium]	62	9.011052e-04
HPA	HPA:0360053	Parathyroid gland; glandular cells[High]	Parathyroid gland; glandular cells[High]	27	9.321494e-04
HPA	HPA:0090183	Cerebellum; cells in granular layer[High]	Cerebellum; cells in granular layer[High]	18	9.403019e-04
HPA	HPA:0130202	Colon; endothelial cells[≥Medium]	Colon; endothelial cells[≥Medium]	46	9.697734e-04
HPA	HPA:0380512	Placenta; decidual cells[≥Medium]	Placenta; decidual cells[≥Medium]	45	9.708579e-04
HPA	HPA:0100131	Cerebral cortex; neuronal cells[≥Low]	Cerebral cortex; neuronal cells[≥Low]	66	1.029143e-03
HPA	HPA:0150891	Duodenum; goblet cells[≥Low]	Duodenum; goblet cells[≥Low]	13	1.086665e-03
HPA	HPA:0220051	Gallbladder; glandular cells[≥Low]	Gallbladder; glandular cells[≥Low]	71	1.116438e-03
HPA	HPA:0220000	Gallbladder	Gallbladder	71	1.116438e-03
HPA	HPA:0030893	Appendix; goblet cells[High]	Appendix; goblet cells[High]	9	1.126357e-03
HPA	HPA:0030073	Appendix; lymphoid tissue[High]	Appendix; lymphoid tissue[High]	18	1.131241e-03
HPA	HPA:0030072	Appendix; lymphoid tissue[≥Medium]	Appendix; lymphoid tissue[≥Medium]	40	1.186099e-03
HPA	HPA:0080133	Caudate; neuronal cells[High]	Caudate; neuronal cells[High]	22	1.224200e-03
HPA	HPA:0480000	Small intestine	Small intestine	72	1.239655e-03
HPA	HPA:0380511	Placenta; decidual cells[≥Low]	Placenta; decidual cells[≥Low]	54	1.276901e-03
HPA	HPA:0151303	Duodenum; enterocytes[High]	Duodenum; enterocytes[High]	10	1.314416e-03
HPA	HPA:0340453	Ovary; follicle cells[High]	Ovary; follicle cells[High]	16	1.322611e-03
HPA	HPA:0490691	Smooth muscle; smooth muscle cells[≥Low]	Smooth muscle; smooth muscle cells[≥Low]	58	1.434425e-03
HPA	HPA:0490000	Smooth muscle	Smooth muscle	58	1.434425e-03
HPA	HPA:0320101	Nasopharynx; respiratory epithelial cells[≥Low]	Nasopharynx; respiratory epithelial cells[≥Low]	60	1.507868e-03
HPA	HPA:0570762	Testis; pachytene spermatocytes[≥Medium]	Testis; pachytene spermatocytes[≥Medium]	30	1.600212e-03
HPA	HPA:0030443	Appendix; non-germinal center cells[High]	Appendix; non-germinal center cells[High]	7	1.985928e-03
HPA	HPA:0380522	Placenta; trophoblastic cells[≥Medium]	Placenta; trophoblastic cells[≥Medium]	55	2.006570e-03
HPA	HPA:0060102	Bronchus; respiratory epithelial cells[≥Medium]	Bronchus; respiratory epithelial cells[≥Medium]	54	2.160104e-03
HPA	HPA:0510701	Soft tissue 2; peripheral nerve[≥Low]	Soft tissue 2; peripheral nerve[≥Low]	41	2.474714e-03
HPA	HPA:0151352	Duodenum; paneth cells[≥Medium]	Duodenum; paneth cells[≥Medium]	10	2.525093e-03
HPA	HPA:0090163	Cerebellum; Purkinje cells[High]	Cerebellum; Purkinje cells[High]	26	3.017489e-03
HPA	HPA:0090162	Cerebellum; Purkinje cells[≥Medium]	Cerebellum; Purkinje cells[≥Medium]	48	3.027946e-03
HPA	HPA:0550000	Stomach 2	Stomach 2	70	3.198159e-03
HPA	HPA:0550051	Stomach 2; glandular cells[≥Low]	Stomach 2; glandular cells[≥Low]	70	3.198159e-03
HPA	HPA:0151292	Duodenum; endocrine cells[≥Medium]	Duodenum; endocrine cells[≥Medium]	13	3.315701e-03
HPA	HPA:0090181	Cerebellum; cells in granular layer[≥Low]	Cerebellum; cells in granular layer[≥Low]	51	3.319431e-03
HPA	HPA:0210051	Fallopian tube; glandular cells[≥Low]	Fallopian tube; glandular cells[≥Low]	59	3.849461e-03
HPA	HPA:0060101	Bronchus; respiratory epithelial cells[≥Low]	Bronchus; respiratory epithelial cells[≥Low]	60	4.144680e-03
HPA	HPA:0160052	Endometrium 1; glandular cells[≥Medium]	Endometrium 1; glandular cells[≥Medium]	55	4.305248e-03
HPA	HPA:0630052	Cervix; glandular cells[≥Medium]	Cervix; glandular cells[≥Medium]	47	4.390432e-03
HPA	HPA:0420052	Salivary gland; glandular cells[≥Medium]	Salivary gland; glandular cells[≥Medium]	53	4.578437e-03
HPA	HPA:0461482	Skin 1; sebaceous glands[≥Medium]	Skin 1; sebaceous glands[≥Medium]	8	4.918879e-03
HPA	HPA:0151353	Duodenum; paneth cells[High]	Duodenum; paneth cells[High]	8	5.366617e-03
HPA	HPA:0090182	Cerebellum; cells in granular layer[≥Medium]	Cerebellum; cells in granular layer[≥Medium]	38	5.492731e-03
HPA	HPA:0151351	Duodenum; paneth cells[≥Low]	Duodenum; paneth cells[≥Low]	10	5.914868e-03
HPA	HPA:0570761	Testis; pachytene spermatocytes[≥Low]	Testis; pachytene spermatocytes[≥Low]	33	6.437503e-03
HPA	HPA:0030432	Appendix; germinal center cells[≥Medium]	Appendix; germinal center cells[≥Medium]	9	7.010298e-03
HPA	HPA:0031293	Appendix; endocrine cells[High]	Appendix; endocrine cells[High]	9	7.513695e-03
HPA	HPA:0080131	Caudate; neuronal cells[≥Low]	Caudate; neuronal cells[≥Low]	61	7.714893e-03
HPA	HPA:0100203	Cerebral cortex; endothelial cells[High]	Cerebral cortex; endothelial cells[High]	12	8.385405e-03
HPA	HPA:0460663	Skin 1; keratinocytes[High]	Skin 1; keratinocytes[High]	15	9.770913e-03
HPA	HPA:0570802	Testis; sertoli cells[≥Medium]	Testis; sertoli cells[≥Medium]	28	1.002628e-02
HPA	HPA:0490692	Smooth muscle; smooth muscle cells[≥Medium]	Smooth muscle; smooth muscle cells[≥Medium]	39	1.016703e-02
HPA	HPA:0030433	Appendix; germinal center cells[High]	Appendix; germinal center cells[High]	6	1.021848e-02
HPA	HPA:0590052	Thyroid gland; glandular cells[≥Medium]	Thyroid gland; glandular cells[≥Medium]	57	1.146998e-02
HPA	HPA:0530712	Spleen; cells in red pulp[≥Medium]	Spleen; cells in red pulp[≥Medium]	39	1.207204e-02
HPA	HPA:0151293	Duodenum; endocrine cells[High]	Duodenum; endocrine cells[High]	10	1.230504e-02
HPA	HPA:0570791	Testis; round or early spermatids[≥Low]	Testis; round or early spermatids[≥Low]	32	1.245119e-02
HPA	HPA:0500701	Soft tissue 1; peripheral nerve[≥Low]	Soft tissue 1; peripheral nerve[≥Low]	36	1.295171e-02
HPA	HPA:0130241	Colon; peripheral nerve/ganglion[≥Low]	Colon; peripheral nerve/ganglion[≥Low]	53	1.403234e-02
HPA	HPA:0340451	Ovary; follicle cells[≥Low]	Ovary; follicle cells[≥Low]	40	1.568190e-02
HPA	HPA:0530723	Spleen; cells in white pulp[High]	Spleen; cells in white pulp[High]	17	1.741589e-02
HPA	HPA:0380523	Placenta; trophoblastic cells[High]	Placenta; trophoblastic cells[High]	28	1.953466e-02
HPA	HPA:0270363	Kidney; cells in tubules[High]	Kidney; cells in tubules[High]	30	2.070774e-02
HPA	HPA:0461481	Skin 1; sebaceous glands[≥Low]	Skin 1; sebaceous glands[≥Low]	8	2.076746e-02
HPA	HPA:0481353	Small intestine; paneth cells[High]	Small intestine; paneth cells[High]	7	2.119363e-02
HPA	HPA:0500111	Soft tissue 1; chondrocytes[≥Low]	Soft tissue 1; chondrocytes[≥Low]	30	2.624078e-02
HPA	HPA:0380521	Placenta; trophoblastic cells[≥Low]	Placenta; trophoblastic cells[≥Low]	61	2.707729e-02
HPA	HPA:0471452	Skin 2; hair follicles[≥Medium]	Skin 2; hair follicles[≥Medium]	7	3.175114e-02
HPA	HPA:0030431	Appendix; germinal center cells[≥Low]	Appendix; germinal center cells[≥Low]	9	4.291202e-02
HPA	HPA:0481352	Small intestine; paneth cells[≥Medium]	Small intestine; paneth cells[≥Medium]	8	4.516222e-02
HPA	HPA:0080132	Caudate; neuronal cells[≥Medium]	Caudate; neuronal cells[≥Medium]	45	4.863709e-02
HPA	HPA:0100202	Cerebral cortex; endothelial cells[≥Medium]	Cerebral cortex; endothelial cells[≥Medium]	32	4.878613e-02

source	term_id	annotation	description	intersection_size	p_value
MIRNA	MIRNA:hsa-mir-615-3p	hsa-mir-615-3p	hsa-mir-615-3p	35	3.031932e-19
MIRNA	MIRNA:hsa-mir-16-5p	hsa-mir-16-5p	hsa-mir-16-5p	33	3.568558e-11
MIRNA	MIRNA:hsa-mir-92a-3p	hsa-mir-92a-3p	hsa-mir-92a-3p	27	8.245235e-08
MIRNA	MIRNA:hsa-mir-193b-3p	hsa-mir-193b-3p	hsa-mir-193b-3p	19	1.199311e-05
MIRNA	MIRNA:hsa-mir-30a-5p	hsa-mir-30a-5p	hsa-mir-30a-5p	17	4.679877e-05
MIRNA	MIRNA:hsa-mir-744-5p	hsa-mir-744-5p	hsa-mir-744-5p	13	6.352822e-05
MIRNA	MIRNA:hsa-mir-30c-5p	hsa-mir-30c-5p	hsa-mir-30c-5p	14	1.443679e-04
MIRNA	MIRNA:hsa-mir-149-5p	hsa-mir-149-5p	hsa-mir-149-5p	12	3.155988e-04
MIRNA	MIRNA:hsa-mir-15b-5p	hsa-mir-15b-5p	hsa-mir-15b-5p	16	4.794536e-04
MIRNA	MIRNA:hsa-mir-320a	hsa-mir-320a	hsa-mir-320a	25	4.883455e-04
MIRNA	MIRNA:hsa-mir-17-3p	hsa-mir-17-3p	hsa-mir-17-3p	8	7.172503e-04
MIRNA	MIRNA:hsa-mir-378a-3p	hsa-mir-378a-3p	hsa-mir-378a-3p	8	1.232908e-03
MIRNA	MIRNA:hsa-mir-17-5p	hsa-mir-17-5p	hsa-mir-17-5p	19	2.200930e-03
MIRNA	MIRNA:hsa-mir-1301-3p	hsa-mir-1301-3p	hsa-mir-1301-3p	8	4.131827e-03
MIRNA	MIRNA:hsa-mir-877-3p	hsa-mir-877-3p	hsa-mir-877-3p	13	4.654069e-03
MIRNA	MIRNA:hsa-mir-15a-5p	hsa-mir-15a-5p	hsa-mir-15a-5p	14	5.584905e-03
MIRNA	MIRNA:hsa-mir-296-3p	hsa-mir-296-3p	hsa-mir-296-3p	15	6.161920e-03
MIRNA	MIRNA:hsa-mir-125b-5p	hsa-mir-125b-5p	hsa-mir-125b-5p	11	6.486263e-03
MIRNA	MIRNA:hsa-mir-26a-5p	hsa-mir-26a-5p	hsa-mir-26a-5p	11	8.680625e-03
MIRNA	MIRNA:hsa-mir-3617	hsa-mir-3617	hsa-mir-3617	19	9.515064e-03
MIRNA	MIRNA:hsa-mir-25-3p	hsa-mir-25-3p	hsa-mir-25-3p	11	1.033109e-02
MIRNA	MIRNA:hsa-mir-877-5p	hsa-mir-877-5p	hsa-mir-877-5p	8	1.071612e-02
MIRNA	MIRNA:hsa-mir-221-3p	hsa-mir-221-3p	hsa-mir-221-3p	10	1.205012e-02
MIRNA	MIRNA:hsa-mir-641	hsa-mir-641	hsa-mir-641	19	1.645909e-02
MIRNA	MIRNA:hsa-mir-222-3p	hsa-mir-222-3p	hsa-mir-222-3p	10	1.673501e-02
MIRNA	MIRNA:hsa-mir-4694-3p	hsa-mir-4694-3p	hsa-mir-4694-3p	19	1.682097e-02
MIRNA	MIRNA:hsa-mir-1296-5p	hsa-mir-1296-5p	hsa-mir-1296-5p	6	1.892211e-02
MIRNA	MIRNA:hsa-mir-484	hsa-mir-484	hsa-mir-484	24	2.588430e-02
MIRNA	MIRNA:hsa-mir-580	hsa-mir-580	hsa-mir-580	17	2.906656e-02
MIRNA	MIRNA:hsa-mir-18a-5p	hsa-mir-18a-5p	hsa-mir-18a-5p	8	3.380089e-02
MIRNA	MIRNA:hsa-mir-548z	hsa-mir-548z	hsa-mir-548z	23	3.578503e-02
MIRNA	MIRNA:hsa-mir-548ac	hsa-mir-548ac	hsa-mir-548ac	23	3.578503e-02
MIRNA	MIRNA:hsa-mir-548d-3p	hsa-mir-548d-3p	hsa-mir-548d-3p	23	3.732399e-02
MIRNA	MIRNA:hsa-mir-324-5p	hsa-mir-324-5p	hsa-mir-324-5p	14	3.764269e-02
MIRNA	MIRNA:hsa-mir-375	hsa-mir-375	hsa-mir-375	16	3.966308e-02
MIRNA	MIRNA:hsa-mir-3662	hsa-mir-3662	hsa-mir-3662	26	4.042897e-02
MIRNA	MIRNA:hsa-mir-496	hsa-mir-496	hsa-mir-496	12	4.152125e-02
MIRNA	MIRNA:hsa-mir-200a	hsa-mir-200a	hsa-mir-200a	20	4.214953e-02
MIRNA	MIRNA:hsa-mir-141	hsa-mir-141	hsa-mir-141	20	4.214953e-02

source	term_id	annotation	description	intersection_size	p_value
WP	WP:WP5426	HDAC6 interactions in the central nervous system	HDAC6 interactions in the central nervous system	17	2.887915e-14
WP	WP:WP2359	Parkin ubiquitin proteasomal system pathway	Parkin ubiquitin proteasomal system pathway	9	3.083954e-06
WP	WP:WP411	mRNA processing	mRNA processing	11	3.901715e-06
WP	WP:WP3594	Circadian rhythm genes	Circadian rhythm genes	13	6.543124e-06
WP	WP:WP2036	TNF related weak inducer of apoptosis TWEAK signaling	TNF related weak inducer of apoptosis TWEAK signaling	7	9.103920e-06
WP	WP:WP4659	Gastrin signaling	Gastrin signaling	10	1.717011e-05
WP	WP:WP5475	Hallmark of cancer sustaining proliferative signaling	Hallmark of cancer sustaining proliferative signaling	9	5.313899e-05
WP	WP:WP3981	miRNA regulation of prostate cancer signaling	miRNA regulation of prostate cancer signaling	6	6.404222e-05
WP	WP:WP2380	Brain derived neurotrophic factor BDNF signaling	Brain derived neurotrophic factor BDNF signaling	10	9.724643e-05
WP	WP:WP5353	Macrophage stimulating protein MSP signaling	Macrophage stimulating protein MSP signaling	9	1.224634e-04
WP	WP:WP4016	DNA IR damage and cellular response via ATR	DNA IR damage and cellular response via ATR	8	1.448046e-04
WP	WP:WP4754	IL18 signaling	IL18 signaling	7	1.461038e-04
WP	WP:WP5331	Autophagy in pancreatic ductal adenocarcinoma	Autophagy in pancreatic ductal adenocarcinoma	5	1.653572e-04
WP	WP:WP254	Apoptosis	Apoptosis	8	2.514151e-04
WP	WP:WP3888	VEGFA VEGFR2 signaling	VEGFA VEGFR2 signaling	16	3.402415e-04
WP	WP:WP2355	Corticotropin releasing hormone signaling	Corticotropin releasing hormone signaling	8	3.547818e-04
WP	WP:WP706	Sudden infant death syndrome SIDS susceptibility pathways	Sudden infant death syndrome SIDS susceptibility pathways	10	3.829192e-04
WP	WP:WP5049	Glycolysis in senescence	Glycolysis in senescence	4	4.192610e-04
WP	WP:WP3303	RAC1 PAK1 p38 MMP2 pathway	RAC1 PAK1 p38 MMP2 pathway	7	5.580155e-04
WP	WP:WP2037	Prolactin signaling	Prolactin signaling	7	9.901424e-04
WP	WP:WP3286	Copper homeostasis	Copper homeostasis	6	1.349349e-03
WP	WP:WP710	DNA damage response only ATM dependent	DNA damage response only ATM dependent	8	1.384377e-03
WP	WP:WP2864	Apoptosis related network due to altered Notch3 in ovarian cancer	Apoptosis related network due to altered Notch3 in ovarian cancer	6	1.694621e-03
WP	WP:WP2263	Androgen receptor network in prostate cancer	Androgen receptor network in prostate cancer	8	1.809208e-03
WP	WP:WP1984	Integrated breast cancer pathway	Integrated breast cancer pathway	9	2.104647e-03
WP	WP:WP3959	DNA IR double strand breaks and cellular response via ATM	DNA IR double strand breaks and cellular response via ATM	6	2.108228e-03
WP	WP:WP2272	Pathogenic Escherichia coli infection	Pathogenic Escherichia coli infection	6	2.108228e-03
WP	WP:WP3646	Hepatitis C and hepatocellular carcinoma	Hepatitis C and hepatocellular carcinoma	6	2.343683e-03
WP	WP:WP138	Androgen receptor signaling	Androgen receptor signaling	7	2.500178e-03
WP	WP:WP382	MAPK signaling	MAPK signaling	11	2.983645e-03
WP	WP:WP5381	Smith Magenis and Potocki Lupski syndrome copy number variation	Smith Magenis and Potocki Lupski syndrome copy number variation	9	3.025991e-03
WP	WP:WP5098	T cell activation SARS CoV 2	T cell activation SARS CoV 2	7	3.143952e-03
WP	WP:WP2446	Retinoblastoma gene in cancer	Retinoblastoma gene in cancer	7	3.386787e-03
WP	WP:WP45	G1 to S cell cycle control	G1 to S cell cycle control	6	5.098761e-03
WP	WP:WP707	DNA damage response	DNA damage response	6	7.854502e-03
WP	WP:WP5158	Urotensin II mediated signaling	Urotensin II mediated signaling	6	7.854502e-03
WP	WP:WP5046	NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence	NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence	4	8.591558e-03
WP	WP:WP5294	Sildenafil treatment	Sildenafil treatment	4	8.591558e-03
WP	WP:WP4141	PI3K AKT mTOR vitamin D3 signaling	PI3K AKT mTOR vitamin D3 signaling	4	8.591558e-03
WP	WP:WP712	Estrogen signaling	Estrogen signaling	4	1.032640e-02
WP	WP:WP4216	Chromosomal and microsatellite instability in colorectal cancer	Chromosomal and microsatellite instability in colorectal cancer	6	1.082645e-02
WP	WP:WP4674	Head and neck squamous cell carcinoma	Head and neck squamous cell carcinoma	6	1.169436e-02
WP	WP:WP4666	Hepatitis B infection	Hepatitis B infection	8	1.543358e-02
WP	WP:WP3658	Wnt beta catenin signaling in leukemia	Wnt beta catenin signaling in leukemia	4	1.706530e-02
WP	WP:WP2018	RANKL RANK signaling	RANKL RANK signaling	5	1.813306e-02
WP	WP:WP4747	Netrin UNC5B signaling	Netrin UNC5B signaling	5	2.191943e-02
WP	WP:WP3875	ATR signaling	ATR signaling	3	2.311831e-02
WP	WP:WP179	Cell cycle	Cell cycle	7	2.316597e-02
WP	WP:WP195	IL1 signaling	IL1 signaling	5	2.628475e-02
WP	WP:WP5124	Alzheimer 39 s disease	Alzheimer 39 s disease	10	2.731527e-02
WP	WP:WP2059	Alzheimer 39 s disease and miRNA effects	Alzheimer 39 s disease and miRNA effects	10	3.192574e-02
WP	WP:WP673	ErbB signaling	ErbB signaling	6	3.281076e-02
WP	WP:WP231	TNF alpha signaling	TNF alpha signaling	6	3.281076e-02
WP	WP:WP2839	Hair follicle development organogenesis stage 2 of 3	Hair follicle development organogenesis stage 2 of 3	4	3.933107e-02
WP	WP:WP2112	IL17 signaling	IL17 signaling	4	3.933107e-02
WP	WP:WP23	B cell receptor signaling	B cell receptor signaling	6	3.937379e-02
WP	WP:WP4628	Aerobic glycolysis augmented	Aerobic glycolysis augmented	3	3.953251e-02
WP	WP:WP5434	Cancer pathways	Cancer pathways	14	4.112795e-02
WP	WP:WP4658	Small cell lung cancer	Small cell lung cancer	6	4.693187e-02

source	term_id	annotation	description	intersection_size	p_value
REAC	REAC:R-HSA-3371556	Cellular response to heat stress	Cellular response to heat stress	14	5.798634e-13
REAC	REAC:R-HSA-3371511	HSF1 activation	HSF1 activation	8	1.133179e-12
REAC	REAC:R-HSA-1643685	Disease	Disease	43	2.620460e-11
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	32	2.741566e-10
REAC	REAC:R-HSA-2262752	Cellular responses to stress	Cellular responses to stress	28	3.127371e-10
REAC	REAC:R-HSA-8953897	Cellular responses to stimuli	Cellular responses to stimuli	28	4.791985e-10
REAC	REAC:R-HSA-9613829	Chaperone Mediated Autophagy	Chaperone Mediated Autophagy	7	5.437354e-08
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	26	1.085601e-07
REAC	REAC:R-HSA-3371453	Regulation of HSF1-mediated heat shock response	Regulation of HSF1-mediated heat shock response	9	4.721639e-07
REAC	REAC:R-HSA-392499	Metabolism of proteins	Metabolism of proteins	39	6.376835e-07
REAC	REAC:R-HSA-9663891	Selective autophagy	Selective autophagy	9	2.371171e-06
REAC	REAC:R-HSA-9612973	Autophagy	Autophagy	11	4.037721e-06
REAC	REAC:R-HSA-212436	Generic Transcription Pathway	Generic Transcription Pathway	28	8.606209e-06
REAC	REAC:R-HSA-1280215	Cytokine Signaling in Immune system	Cytokine Signaling in Immune system	22	1.007616e-05
REAC	REAC:R-HSA-9646399	Aggrephagy	Aggrephagy	7	1.072956e-05
REAC	REAC:R-HSA-168256	Immune System	Immune System	37	1.313338e-05
REAC	REAC:R-HSA-5357801	Programmed Cell Death	Programmed Cell Death	12	1.322239e-05
REAC	REAC:R-HSA-449147	Signaling by Interleukins	Signaling by Interleukins	17	1.874664e-05
REAC	REAC:R-HSA-9678108	SARS-CoV-1 Infection	SARS-CoV-1 Infection	10	2.714726e-05
REAC	REAC:R-HSA-9820965	Respiratory syncytial virus (RSV) genome replication, transcription and translation	Respiratory syncytial virus (RSV) genome replication, transcription and translation	5	3.030519e-05
REAC	REAC:R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	Diseases of signal transduction by growth factor receptors and second messengers	16	4.381482e-05
REAC	REAC:R-HSA-74160	Gene expression (Transcription)	Gene expression (Transcription)	30	5.169128e-05
REAC	REAC:R-HSA-73857	RNA Polymerase II Transcription	RNA Polymerase II Transcription	28	6.470430e-05
REAC	REAC:R-HSA-597592	Post-translational protein modification	Post-translational protein modification	29	7.273569e-05
REAC	REAC:R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	Regulation of mRNA stability by proteins that bind AU-rich elements	8	7.838114e-05
REAC	REAC:R-HSA-110320	Translesion Synthesis by POLH	Translesion Synthesis by POLH	5	7.929097e-05
REAC	REAC:R-HSA-72163	mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway	11	9.293693e-05
REAC	REAC:R-HSA-9755511	KEAP1-NFE2L2 pathway	KEAP1-NFE2L2 pathway	9	1.118064e-04
REAC	REAC:R-HSA-1640170	Cell Cycle	Cell Cycle	19	1.266880e-04
REAC	REAC:R-HSA-72172	mRNA Splicing	mRNA Splicing	11	1.309488e-04
REAC	REAC:R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	6	1.373660e-04
REAC	REAC:R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	SUMO E3 ligases SUMOylate target proteins	10	1.873378e-04
REAC	REAC:R-HSA-9824439	Bacterial Infection Pathways	Bacterial Infection Pathways	7	1.915097e-04
REAC	REAC:R-HSA-1632852	Macroautophagy	Macroautophagy	9	2.166363e-04
REAC	REAC:R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	Deactivation of the beta-catenin transactivating complex	6	2.170186e-04
REAC	REAC:R-HSA-8953854	Metabolism of RNA	Metabolism of RNA	19	2.512031e-04
REAC	REAC:R-HSA-2990846	SUMOylation	SUMOylation	10	2.570968e-04
REAC	REAC:R-HSA-162582	Signal Transduction	Signal Transduction	39	2.976108e-04
REAC	REAC:R-HSA-73893	DNA Damage Bypass	DNA Damage Bypass	6	4.901578e-04
REAC	REAC:R-HSA-5689877	Josephin domain DUBs	Josephin domain DUBs	4	4.998234e-04
REAC	REAC:R-HSA-69275	G2/M Transition	G2/M Transition	10	6.203354e-04
REAC	REAC:R-HSA-5688426	Deubiquitination	Deubiquitination	12	6.433582e-04
REAC	REAC:R-HSA-453274	Mitotic G2-G2/M phases	Mitotic G2-G2/M phases	10	6.801681e-04
REAC	REAC:R-HSA-209560	NF-kB is activated and signals survival	NF-kB is activated and signals survival	4	7.179293e-04
REAC	REAC:R-HSA-69278	Cell Cycle, Mitotic	Cell Cycle, Mitotic	16	7.535400e-04
REAC	REAC:R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	Respiratory Syncytial Virus Infection Pathway	8	9.528919e-04
REAC	REAC:R-HSA-5633007	Regulation of TP53 Activity	Regulation of TP53 Activity	9	9.587126e-04
REAC	REAC:R-HSA-3371568	Attenuation phase	Attenuation phase	4	9.994805e-04
REAC	REAC:R-HSA-5213460	RIPK1-mediated regulated necrosis	RIPK1-mediated regulated necrosis	5	1.081180e-03
REAC	REAC:R-HSA-5675482	Regulation of necroptotic cell death	Regulation of necroptotic cell death	5	1.081180e-03
REAC	REAC:R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	Regulation of PLK1 Activity at G2/M Transition	7	1.085081e-03
REAC	REAC:R-HSA-5656169	Termination of translesion DNA synthesis	Termination of translesion DNA synthesis	5	1.274037e-03
REAC	REAC:R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	6	1.375117e-03
REAC	REAC:R-HSA-9725370	Signaling by ALK fusions and activated point mutants	Signaling by ALK fusions and activated point mutants	7	1.479424e-03
REAC	REAC:R-HSA-9700206	Signaling by ALK in cancer	Signaling by ALK in cancer	7	1.479424e-03
REAC	REAC:R-HSA-5218859	Regulated Necrosis	Regulated Necrosis	6	1.524841e-03
REAC	REAC:R-HSA-193639	p75NTR signals via NF-kB	p75NTR signals via NF-kB	4	1.796975e-03
REAC	REAC:R-HSA-110312	Translesion synthesis by REV1	Translesion synthesis by REV1	4	1.796975e-03
REAC	REAC:R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	Regulation of TP53 Activity through Phosphorylation	7	1.848017e-03
REAC	REAC:R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	Processing of Capped Intron-Containing Pre-mRNA	11	2.005563e-03
REAC	REAC:R-HSA-9679506	SARS-CoV Infections	SARS-CoV Infections	14	2.151328e-03
REAC	REAC:R-HSA-9759194	Nuclear events mediated by NFE2L2	Nuclear events mediated by NFE2L2	7	2.290121e-03
REAC	REAC:R-HSA-9692914	SARS-CoV-1-host interactions	SARS-CoV-1-host interactions	7	2.290121e-03
REAC	REAC:R-HSA-6804757	Regulation of TP53 Degradation	Regulation of TP53 Degradation	5	2.330778e-03
REAC	REAC:R-HSA-5656121	Translesion synthesis by POLI	Translesion synthesis by POLI	4	2.336757e-03
REAC	REAC:R-HSA-5655862	Translesion synthesis by POLK	Translesion synthesis by POLK	4	2.336757e-03
REAC	REAC:R-HSA-8876725	Protein methylation	Protein methylation	4	2.336757e-03
REAC	REAC:R-HSA-6806003	Regulation of TP53 Expression and Degradation	Regulation of TP53 Expression and Degradation	5	2.679488e-03
REAC	REAC:R-HSA-5336415	Uptake and function of diphtheria toxin	Uptake and function of diphtheria toxin	3	2.931799e-03
REAC	REAC:R-HSA-5689896	Ovarian tumor domain proteases	Ovarian tumor domain proteases	5	3.498696e-03
REAC	REAC:R-HSA-168249	Innate Immune System	Innate Immune System	22	3.609868e-03
REAC	REAC:R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	Toll Like Receptor 3 (TLR3) Cascade	7	3.917173e-03
REAC	REAC:R-HSA-3700989	Transcriptional Regulation by TP53	Transcriptional Regulation by TP53	12	4.361151e-03
REAC	REAC:R-HSA-5696400	Dual Incision in GG-NER	Dual Incision in GG-NER	5	4.501732e-03
REAC	REAC:R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	TRIF (TICAM1)-mediated TLR4 signaling	7	5.035155e-03
REAC	REAC:R-HSA-166166	MyD88-independent TLR4 cascade	MyD88-independent TLR4 cascade	7	5.035155e-03
REAC	REAC:R-HSA-5696395	Formation of Incision Complex in GG-NER	Formation of Incision Complex in GG-NER	5	5.716275e-03
REAC	REAC:R-HSA-9818749	Regulation of NFE2L2 gene expression	Regulation of NFE2L2 gene expression	3	8.122050e-03
REAC	REAC:R-HSA-9711123	Cellular response to chemical stress	Cellular response to chemical stress	9	8.707122e-03
REAC	REAC:R-HSA-3371571	HSF1-dependent transactivation	HSF1-dependent transactivation	4	1.003179e-02
REAC	REAC:R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	DDX58/IFIH1-mediated induction of interferon-alpha/beta	6	1.146537e-02
REAC	REAC:R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	Gap-filling DNA repair synthesis and ligation in GG-NER	4	1.187595e-02
REAC	REAC:R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	Constitutive Signaling by AKT1 E17K in Cancer	4	1.187595e-02
REAC	REAC:R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	4	1.187595e-02
REAC	REAC:R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	Global Genome Nucleotide Excision Repair (GG-NER)	6	1.315490e-02
REAC	REAC:R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	Formation of tubulin folding intermediates by CCT/TriC	4	1.395688e-02
REAC	REAC:R-HSA-5218920	VEGFR2 mediated vascular permeability	VEGFR2 mediated vascular permeability	4	1.629274e-02
REAC	REAC:R-HSA-109581	Apoptosis	Apoptosis	8	1.684795e-02
REAC	REAC:R-HSA-390450	Folding of actin by CCT/TriC	Folding of actin by CCT/TriC	3	1.722007e-02
REAC	REAC:R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	Prefoldin mediated transfer of substrate to CCT/TriC	4	1.890215e-02
REAC	REAC:R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	5	1.928056e-02
REAC	REAC:R-HSA-9694516	SARS-CoV-2 Infection	SARS-CoV-2 Infection	10	2.044146e-02
REAC	REAC:R-HSA-9834752	Respiratory syncytial virus genome replication	Respiratory syncytial virus genome replication	2	2.074405e-02
REAC	REAC:R-HSA-9820962	Assembly and release of respiratory syncytial virus (RSV) virions	Assembly and release of respiratory syncytial virus (RSV) virions	2	2.074405e-02
REAC	REAC:R-HSA-170834	Signaling by TGF-beta Receptor Complex	Signaling by TGF-beta Receptor Complex	6	2.202386e-02
REAC	REAC:R-HSA-69473	G2/M DNA damage checkpoint	G2/M DNA damage checkpoint	6	2.485608e-02
REAC	REAC:R-HSA-114452	Activation of BH3-only proteins	Activation of BH3-only proteins	4	2.501837e-02
REAC	REAC:R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	Recognition of DNA damage by PCNA-containing replication complex	4	2.501837e-02
REAC	REAC:R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	Toll Like Receptor 5 (TLR5) Cascade	6	2.637739e-02
REAC	REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	Transcriptional regulation by RUNX3	6	2.637739e-02
REAC	REAC:R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	Toll Like Receptor 10 (TLR10) Cascade	6	2.637739e-02
REAC	REAC:R-HSA-975871	MyD88 cascade initiated on plasma membrane	MyD88 cascade initiated on plasma membrane	6	2.637739e-02
REAC	REAC:R-HSA-9614399	Regulation of localization of FOXO transcription factors	Regulation of localization of FOXO transcription factors	3	3.123598e-02
REAC	REAC:R-HSA-9755779	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	3	3.123598e-02
REAC	REAC:R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	Toll Like Receptor 4 (TLR4) Cascade	7	3.264582e-02
REAC	REAC:R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	6	3.513847e-02
REAC	REAC:R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	4	3.673505e-02
REAC	REAC:R-HSA-975155	MyD88 dependent cascade initiated on endosome	MyD88 dependent cascade initiated on endosome	6	3.714043e-02
REAC	REAC:R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	Toll Like Receptor 7/8 (TLR7/8) Cascade	6	3.923218e-02
REAC	REAC:R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	Cytosolic sensors of pathogen-associated DNA	5	4.012831e-02
REAC	REAC:R-HSA-9615710	Late endosomal microautophagy	Late endosomal microautophagy	4	4.140102e-02
REAC	REAC:R-HSA-5617833	Cilium Assembly	Cilium Assembly	8	4.145039e-02
REAC	REAC:R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	Toll Like Receptor 9 (TLR9) Cascade	6	4.607546e-02
REAC	REAC:R-HSA-9706574	RHOBTB GTPase Cycle	RHOBTB GTPase Cycle	4	4.648261e-02

source	term_id	annotation	description	intersection_size	p_value
KEGG	KEGG:05215	Prostate cancer	Prostate cancer	10	4.264444e-07
KEGG	KEGG:05134	Legionellosis	Legionellosis	8	1.174462e-06
KEGG	KEGG:05417	Lipid and atherosclerosis	Lipid and atherosclerosis	13	1.234421e-06
KEGG	KEGG:05203	Viral carcinogenesis	Viral carcinogenesis	12	5.708976e-06
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	Pathways of neurodegeneration - multiple diseases	17	1.505400e-05
KEGG	KEGG:04218	Cellular senescence	Cellular senescence	10	3.815062e-05
KEGG	KEGG:05132	Salmonella infection	Salmonella infection	12	5.847911e-05
KEGG	KEGG:04210	Apoptosis	Apoptosis	9	1.137896e-04
KEGG	KEGG:05418	Fluid shear stress and atherosclerosis	Fluid shear stress and atherosclerosis	9	1.368144e-04
KEGG	KEGG:04390	Hippo signaling pathway	Hippo signaling pathway	9	3.987412e-04
KEGG	KEGG:05160	Hepatitis C	Hepatitis C	9	4.200731e-04
KEGG	KEGG:05161	Hepatitis B	Hepatitis B	9	5.155022e-04
KEGG	KEGG:05012	Parkinson disease	Parkinson disease	11	7.522381e-04
KEGG	KEGG:04657	IL-17 signaling pathway	IL-17 signaling pathway	7	7.657503e-04
KEGG	KEGG:05162	Measles	Measles	8	1.283684e-03
KEGG	KEGG:04612	Antigen processing and presentation	Antigen processing and presentation	6	1.606207e-03
KEGG	KEGG:04137	Mitophagy - animal	Mitophagy - animal	7	1.612009e-03
KEGG	KEGG:05202	Transcriptional misregulation in cancer	Transcriptional misregulation in cancer	9	2.026441e-03
KEGG	KEGG:05167	Kaposi sarcoma-associated herpesvirus infection	Kaposi sarcoma-associated herpesvirus infection	9	2.200008e-03
KEGG	KEGG:05131	Shigellosis	Shigellosis	10	2.389223e-03
KEGG	KEGG:05220	Chronic myeloid leukemia	Chronic myeloid leukemia	6	2.799427e-03
KEGG	KEGG:05207	Chemical carcinogenesis - receptor activation	Chemical carcinogenesis - receptor activation	9	4.257419e-03
KEGG	KEGG:04919	Thyroid hormone signaling pathway	Thyroid hormone signaling pathway	7	4.568277e-03
KEGG	KEGG:04141	Protein processing in endoplasmic reticulum	Protein processing in endoplasmic reticulum	8	5.284350e-03
KEGG	KEGG:05166	Human T-cell leukemia virus 1 infection	Human T-cell leukemia virus 1 infection	9	5.486170e-03
KEGG	KEGG:05210	Colorectal cancer	Colorectal cancer	6	5.643081e-03
KEGG	KEGG:05200	Pathways in cancer	Pathways in cancer	14	6.502041e-03
KEGG	KEGG:05163	Human cytomegalovirus infection	Human cytomegalovirus infection	9	6.536542e-03
KEGG	KEGG:03040	Spliceosome	Spliceosome	8	6.767754e-03
KEGG	KEGG:04114	Oocyte meiosis	Oocyte meiosis	7	7.565011e-03
KEGG	KEGG:05222	Small cell lung cancer	Small cell lung cancer	6	8.232835e-03
KEGG	KEGG:05213	Endometrial cancer	Endometrial cancer	5	8.586028e-03
KEGG	KEGG:04915	Estrogen signaling pathway	Estrogen signaling pathway	7	9.575879e-03
KEGG	KEGG:04151	PI3K-Akt signaling pathway	PI3K-Akt signaling pathway	11	1.129391e-02
KEGG	KEGG:04010	MAPK signaling pathway	MAPK signaling pathway	10	1.298236e-02
KEGG	KEGG:05169	Epstein-Barr virus infection	Epstein-Barr virus infection	8	1.659298e-02
KEGG	KEGG:05415	Diabetic cardiomyopathy	Diabetic cardiomyopathy	8	1.902401e-02
KEGG	KEGG:04931	Insulin resistance	Insulin resistance	6	1.992204e-02
KEGG	KEGG:05145	Toxoplasmosis	Toxoplasmosis	6	1.992204e-02
KEGG	KEGG:05205	Proteoglycans in cancer	Proteoglycans in cancer	8	2.103322e-02
KEGG	KEGG:04110	Cell cycle	Cell cycle	7	2.330971e-02
KEGG	KEGG:04722	Neurotrophin signaling pathway	Neurotrophin signaling pathway	6	3.215955e-02
KEGG	KEGG:04662	B cell receptor signaling pathway	B cell receptor signaling pathway	5	4.146661e-02
KEGG	KEGG:04310	Wnt signaling pathway	Wnt signaling pathway	7	4.343502e-02

source	term_id	annotation	description	intersection_size	p_value
HP	HP:0100526	Neoplasm of the lung	Tumor of the lung.	8	0.000056
HP	HP:0100606	Neoplasm of the respiratory system	A tumor (abnormal growth of tissue) of the respiratory system.	8	0.000246
HP	HP:0030223	Perseverative thought	The repetitive production of the same response to different commands.	5	0.000653
HP	HP:0025769	Disordered formal thought process	An abnormality in the dynamic mode, rate, or form of thought processes as recognized from the flow of ideas expressed in speech. Successive thoughts and speech are easily diverted by external stimuli or internal superficial associations. Unable to maintain a constant train of thought and loose themselves in side issues, losing the thread and are unable to recover it. Superficial connections appear to drive the subject matter.	6	0.000663
HP	HP:0007373	Motor neuron atrophy	Wasting involving the motor neuron.	7	0.000985
HP	HP:0011793	Neoplasm by anatomical site	Neoplasm categorized according to the anatomical site of origin of the neoplasm.	22	0.001594
HP	HP:0002380	Fasciculations	Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units.	9	0.001683
HP	HP:0002442	Dyscalculia	A specific learning disability involving mathematics and arithmetic.	5	0.001745
HP	HP:0100728	Germ cell neoplasia	Germ cell neoplasia	6	0.001925
HP	HP:0002366	Abnormal lower motor neuron morphology	Any structural anomaly of the lower motor neuron.	5	0.002167
HP	HP:0010785	Gonadal neoplasm	A tumor (abnormal growth of tissue) of a gonad.	8	0.002368
HP	HP:0002664	Neoplasm	An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).	22	0.002538
HP	HP:0100615	Ovarian neoplasm	A tumor (abnormal growth of tissue) of the ovary.	7	0.002990
HP	HP:0002450	Abnormal motor neuron morphology	Any structural anomaly that affects the motor neuron.	7	0.003277
HP	HP:0011960	Substantia nigra gliosis	Focal proliferation of glial cells in the substantia nigra.	4	0.004070
HP	HP:0100314	Cerebral inclusion bodies	Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain.	6	0.004174
HP	HP:0100315	Lewy bodies	Lewy bodies	5	0.004724
HP	HP:0010787	Genital neoplasm	A tumor (abnormal growth of tissue) of the genital system.	9	0.005114
HP	HP:0100705	Abnormal glial cell morphology	An abnormality of the glia cell.	9	0.005398
HP	HP:0012757	Abnormal neuron morphology	A structural anomaly of a neuron. Neurons are electrically excitable cells that transmit signals throughout the body. Neurons employ both electrical and chemical components in the transmission of information. Neurons are connected to other neurons at synapses and connected to effector organs or cells at neuroeffector junctions.	7	0.006007
HP	HP:0010788	Testicular neoplasm	The presence of a neoplasm of the testis.	5	0.009209
HP	HP:0010936	Abnormality of the lower urinary tract	An abnormality of the lower urinary tract.	20	0.009376
HP	HP:0100848	Neoplasm of the male external genitalia	A tumor (abnormal growth of tissue) of the male external genitalia.	5	0.010729
HP	HP:0100242	Sarcoma	A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant.	9	0.011057
HP	HP:0002669	Osteosarcoma	A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor.	5	0.016495
HP	HP:0100006	Neoplasm of the central nervous system	A neoplasm of the central nervous system.	9	0.017713
HP	HP:0002171	Gliosis	Gliosis is the focal proliferation of glial cells in the central nervous system.	7	0.021147
HP	HP:0007379	Neoplasm of the genitourinary tract	A tumor (abnormal growth of tissue) of the genitourinary system.	10	0.022274
HP	HP:0000008	Abnormal morphology of female internal genitalia	An abnormality of the female internal genitalia.	14	0.025469
HP	HP:0006774	Ovarian papillary adenocarcinoma	The presence of a papillary adenocarcinoma of the ovary.	3	0.026104
HP	HP:0002362	Shuffling gait	A type of gait (walking) characterized by by dragging one's feet along or without lifting the feet fully from the ground.	5	0.027657
HP	HP:0000711	Restlessness	A state of unease is characterized by diffuse motor activity or motion, which is subject to limited control, nonproductive, or disorganized behavior.	6	0.027943
HP	HP:0004375	Neoplasm of the nervous system	A tumor (abnormal growth of tissue) of the nervous system.	9	0.036909
HP	HP:0045007	Abnormal substantia nigra morphology	A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry.	4	0.039395
HP	HP:0007190	Neuronal loss in the cerebral cortex	Neuronal loss in the cerebral cortex	3	0.041520
HP	HP:0011204	EEG with continuous slow activity	EEG showing diffuse slowing without interruption.	3	0.041520
HP	HP:0012657	Abnormal brain positron emission tomography	A functional brain anomaly detectable by positron emission tomography (PET). PET scanning is a method for functional brain imaging, and its measurements reflect the amount of brain activity in the various regions of the brain.	4	0.047396
HP	HP:0012658	Abnormal brain FDG positron emission tomography	An anomaly detectable in [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) brain scans. Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity.	4	0.047396
HP	HP:0100707	Abnormal astrocyte morphology	An abnormality of astrocytes.	5	0.049031

source	term_id	annotation	description	intersection_size	p_value
TF	TF:M02090_1	Factor: E2F-4; motif: GCGGGAAANA; match class: 1	Factor: E2F-4; motif: GCGGGAAANA; match class: 1	53	0.000060
TF	TF:M07039	Factor: ETF; motif: CCCCGCCCCYN	Factor: ETF; motif: CCCCGCCCCYN	85	0.000665
TF	TF:M00050	Factor: E2F; motif: TTTSGCGC	Factor: E2F; motif: TTTSGCGC	54	0.000672
TF	TF:M09636_1	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1	80	0.000884
TF	TF:M08020	Factor: YY2; motif: NNCCGCCATTW	Factor: YY2; motif: NNCCGCCATTW	22	0.001584
TF	TF:M09894_1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	79	0.002417
TF	TF:M00740	Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC	Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC	67	0.002868
TF	TF:M11601_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	69	0.004956
TF	TF:M03925	Factor: YY2; motif: NCCGCCATNTY	Factor: YY2; motif: NCCGCCATNTY	40	0.005671
TF	TF:M11603_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	76	0.006125
TF	TF:M12271	Factor: ZNF339; motif: NNACCGTTANNNN	Factor: ZNF339; motif: NNACCGTTANNNN	15	0.006425
TF	TF:M00736_1	Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1	Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1	40	0.006672
TF	TF:M04710_1	Factor: CHD2; motif: TCTCGCGAG; match class: 1	Factor: CHD2; motif: TCTCGCGAG; match class: 1	70	0.006900
TF	TF:M11022_1	Factor: IRX2a; motif: ACRYGNNNNACRYGT; match class: 1	Factor: IRX2a; motif: ACRYGNNNNACRYGT; match class: 1	48	0.007623
TF	TF:M12597_1	Factor: E2F1; motif: GSGCGGGAAN; match class: 1	Factor: E2F1; motif: GSGCGGGAAN; match class: 1	64	0.008173
TF	TF:M00695	Factor: ETF; motif: GVGGMGG	Factor: ETF; motif: GVGGMGG	66	0.009458
TF	TF:M08205_1	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1	66	0.009700
TF	TF:M00940_1	Factor: E2F-1; motif: NTTTCGCGCS; match class: 1	Factor: E2F-1; motif: NTTTCGCGCS; match class: 1	28	0.009773
TF	TF:M12554	Factor: YY2; motif: NNATGGCGGCN	Factor: YY2; motif: NNATGGCGGCN	28	0.010208
TF	TF:M04797	Factor: Egr-1; motif: CCGCCCMCG	Factor: Egr-1; motif: CCGCCCMCG	42	0.010542
TF	TF:M12160	Factor: KLF15; motif: RCCMCRCCCMCN	Factor: KLF15; motif: RCCMCRCCCMCN	74	0.012485
TF	TF:M00243	Factor: Egr-1; motif: WTGCGTGGGCGK	Factor: Egr-1; motif: WTGCGTGGGCGK	43	0.013754
TF	TF:M04710	Factor: CHD2; motif: TCTCGCGAG	Factor: CHD2; motif: TCTCGCGAG	78	0.015494
TF	TF:M03925_1	Factor: YY2; motif: NCCGCCATNTY; match class: 1	Factor: YY2; motif: NCCGCCATNTY; match class: 1	14	0.015753
TF	TF:M02090	Factor: E2F-4; motif: GCGGGAAANA	Factor: E2F-4; motif: GCGGGAAANA	71	0.019756
TF	TF:M11654_1	Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1	Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1	6	0.020070
TF	TF:M07084_1	Factor: E2F-4; motif: NGGCGGGAARN; match class: 1	Factor: E2F-4; motif: NGGCGGGAARN; match class: 1	43	0.022660
TF	TF:M04010	Factor: HSF4; motif: TTCTAGAANNTTC	Factor: HSF4; motif: TTCTAGAANNTTC	7	0.024218
TF	TF:M02089	Factor: E2F-3; motif: GGCGGGN	Factor: E2F-3; motif: GGCGGGN	75	0.025493
TF	TF:M07395	Factor: Sp1; motif: NGGGGCGGGGN	Factor: Sp1; motif: NGGGGCGGGGN	66	0.025622
TF	TF:M00986	Factor: Churchill; motif: CGGGNN	Factor: Churchill; motif: CGGGNN	78	0.030184
TF	TF:M00716	Factor: ZF5; motif: GSGCGCGR	Factor: ZF5; motif: GSGCGCGR	83	0.030266
TF	TF:M01199	Factor: RNF96; motif: BCCCGCRGCC	Factor: RNF96; motif: BCCCGCRGCC	57	0.030493
TF	TF:M04109	Factor: RUNX3; motif: NRACCGCAAACCGCAN	Factor: RUNX3; motif: NRACCGCAAACCGCAN	62	0.030797
TF	TF:M09834	Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN	Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN	50	0.031796
TF	TF:M00933	Factor: Sp1; motif: CCCCGCCCCN	Factor: Sp1; motif: CCCCGCCCCN	62	0.033249
TF	TF:M02036_1	Factor: WT1; motif: CGCCCCCNCN; match class: 1	Factor: WT1; motif: CGCCCCCNCN; match class: 1	42	0.034162
TF	TF:M01023_1	Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 1	Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 1	8	0.037777
TF	TF:M03924_1	Factor: YY1; motif: NNCGCCATTNN; match class: 1	Factor: YY1; motif: NNCGCCATTNN; match class: 1	33	0.038282
TF	TF:M07354_1	Factor: Egr-1; motif: GCGGGGGCGG; match class: 1	Factor: Egr-1; motif: GCGGGGGCGG; match class: 1	33	0.038501
TF	TF:M04519_1	Factor: E2F-4; motif: TTTGGCGCCAAA; match class: 1	Factor: E2F-4; motif: TTTGGCGCCAAA; match class: 1	26	0.040044
TF	TF:M02036	Factor: WT1; motif: CGCCCCCNCN	Factor: WT1; motif: CGCCCCCNCN	62	0.040944
TF	TF:M00333_1	Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1	Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1	72	0.043543
TF	TF:M08526_1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	80	0.047770
TF	TF:M00738	Factor: E2F-4:DP-1; motif: TTTSGCGC	Factor: E2F-4:DP-1; motif: TTTSGCGC	62	0.048364

source	term_id	annotation	description	intersection_size	p_value
CORUM	CORUM:1332	Large Drosha complex	Large Drosha complex	6	0.000151
CORUM	CORUM:5199	Kinase maturation complex 1	Kinase maturation complex 1	5	0.001041
CORUM	CORUM:3135	TLE1 corepressor complex (MASH1 promoter-corepressor complex)	TLE1 corepressor complex (MASH1 promoter-corepressor complex)	4	0.001058
CORUM	CORUM:1729	TLE1 corepressor complex (MASH1 promoter-corepressor complex)	TLE1 corepressor complex (MASH1 promoter-corepressor complex)	4	0.003085
CORUM	CORUM:3082	DGCR8 multiprotein complex	DGCR8 multiprotein complex	4	0.003085
CORUM	CORUM:5423	HSP70-BAG5-PARK2 complex	HSP70-BAG5-PARK2 complex	3	0.003554
CORUM	CORUM:1335	SNW1 complex	SNW1 complex	4	0.018697
CORUM	CORUM:2721	HCF-1 complex	HCF-1 complex	4	0.024582
CORUM	CORUM:126	CCT complex (chaperonin containing TCP1 complex)	CCT complex (chaperonin containing TCP1 complex)	3	0.047164
CORUM	CORUM:7284	GSK3B-HSP90AA1-PKM2 complex	GSK3B-HSP90AA1-PKM2 complex	2	0.049911
CORUM	CORUM:1816	JUN-TCF4-CTNNB1 complex	JUN-TCF4-CTNNB1 complex	2	0.049911
CORUM	CORUM:2156	YBX1-AKT1 complex	YBX1-AKT1 complex	2	0.049911
CORUM	CORUM:5229	RPA complex	RPA complex	2	0.049911
CORUM	CORUM:5331	YY1-MDM2-p53 complex	YY1-MDM2-p53 complex	2	0.049911
CORUM	CORUM:5718	NOS3-HSP90-AKT complex, VEGF induced	NOS3-HSP90-AKT complex, VEGF induced	2	0.049911
CORUM	CORUM:6412	AURKA-HDAC6 cilia-disassembly complex	AURKA-HDAC6 cilia-disassembly complex	2	0.049911
CORUM	CORUM:7180	p53-MDM2 complex	p53-MDM2 complex	2	0.049911

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0022626	cytosolic ribosome	"A ribosome located in the cytosol." [GOC:mtg_sensu]	28	7.093667e-52	1
GO:CC	GO:0044391	ribosomal subunit	"Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl]	28	2.357215e-45	1
GO:CC	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	28	2.635535e-32	1
GO:CC	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	15	6.482250e-29	1
GO:CC	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	15	1.787087e-24	1
GO:CC	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	13	4.605922e-22	1
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	20	1.426608e-20	1
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	20	2.268136e-20	1
GO:CC	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	34	5.545587e-20	1
GO:CC	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	13	1.270358e-17	1
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	39	1.024869e-15	1
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	41	3.295980e-15	1
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	41	3.315538e-15	1
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	20	4.347500e-14	1
GO:CC	GO:0030684	preribosome	"Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516]	10	2.835070e-12	1
GO:CC	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	9	5.043627e-12	1
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	25	5.489812e-11	1
GO:CC	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	21	9.175753e-09	1
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	19	3.323664e-08	1
GO:CC	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	37	5.331344e-08	1
GO:CC	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	31	1.656099e-07	1
GO:CC	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	27	4.259696e-07	1
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	43	9.972988e-07	1
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	32	4.213576e-06	1
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	32	4.213576e-06	1
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	32	4.213576e-06	1
GO:CC	GO:0036464	cytoplasmic ribonucleoprotein granule	"A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]	8	1.026471e-05	1
GO:CC	GO:0035770	ribonucleoprotein granule	"A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]	8	1.774957e-05	1
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	45	1.487708e-04	1
GO:CC	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	36	5.082325e-04	1
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	45	1.276778e-03	1
GO:CC	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	4	1.619996e-03	1
GO:CC	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density]	7	1.622840e-03	1
GO:CC	GO:0032279	asymmetric synapse	"A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef]	7	2.158597e-03	1
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	15	2.276900e-03	1
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	15	2.701720e-03	1
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	15	2.717028e-03	1
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	15	2.717028e-03	1
GO:CC	GO:0099572	postsynaptic specialization	"A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028]	7	3.128450e-03	1
GO:CC	GO:0098984	neuron to neuron synapse	"A synapse in which pre and post-synaptic cells are neurons." [GOC:dos]	7	3.977812e-03	1
GO:CC	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	4	8.644621e-03	1
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	45	1.727519e-02	1
GO:CC	GO:0099080	supramolecular complex	"A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]	11	2.619097e-02	1
GO:CC	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	8	3.489529e-02	1

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	SRP-dependent cotranslational protein targeting to membrane	30	3.599471e-50	1
REAC	REAC:R-HSA-72689	Formation of a pool of free 40S subunits	Formation of a pool of free 40S subunits	29	3.769070e-49	1
REAC	REAC:R-HSA-192823	Viral mRNA Translation	Viral mRNA Translation	28	2.038482e-48	1
REAC	REAC:R-HSA-156902	Peptide chain elongation	Peptide chain elongation	28	2.038482e-48	1
REAC	REAC:R-HSA-2408557	Selenocysteine synthesis	Selenocysteine synthesis	28	8.585594e-48	1
REAC	REAC:R-HSA-156842	Eukaryotic Translation Elongation	Eukaryotic Translation Elongation	28	8.585594e-48	1
REAC	REAC:R-HSA-72764	Eukaryotic Translation Termination	Eukaryotic Translation Termination	28	8.585594e-48	1
REAC	REAC:R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	L13a-mediated translational silencing of Ceruloplasmin expression	29	8.676766e-48	1
REAC	REAC:R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	GTP hydrolysis and joining of the 60S ribosomal subunit	29	1.165989e-47	1
REAC	REAC:R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	28	1.714675e-47	1
REAC	REAC:R-HSA-72737	Cap-dependent Translation Initiation	Cap-dependent Translation Initiation	29	8.505866e-47	1
REAC	REAC:R-HSA-72613	Eukaryotic Translation Initiation	Eukaryotic Translation Initiation	29	8.505866e-47	1
REAC	REAC:R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	Response of EIF2AK4 (GCN2) to amino acid deficiency	28	1.237781e-46	1
REAC	REAC:R-HSA-927802	Nonsense-Mediated Decay (NMD)	Nonsense-Mediated Decay (NMD)	28	7.665806e-45	1
REAC	REAC:R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	28	7.665806e-45	1
REAC	REAC:R-HSA-2408522	Selenoamino acid metabolism	Selenoamino acid metabolism	28	1.006591e-44	1
REAC	REAC:R-HSA-168273	Influenza Viral RNA Transcription and Replication	Influenza Viral RNA Transcription and Replication	28	5.651316e-43	1
REAC	REAC:R-HSA-168255	Influenza Infection	Influenza Infection	28	5.223766e-41	1
REAC	REAC:R-HSA-9711097	Cellular response to starvation	Cellular response to starvation	28	9.423862e-41	1
REAC	REAC:R-HSA-9010553	Regulation of expression of SLITs and ROBOs	Regulation of expression of SLITs and ROBOs	28	1.266140e-39	1
REAC	REAC:R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	Major pathway of rRNA processing in the nucleolus and cytosol	28	8.316009e-39	1
REAC	REAC:R-HSA-72766	Translation	Translation	31	9.060590e-39	1
REAC	REAC:R-HSA-8868773	rRNA processing in the nucleus and cytosol	rRNA processing in the nucleus and cytosol	28	4.144546e-38	1
REAC	REAC:R-HSA-72312	rRNA processing	rRNA processing	28	1.890481e-37	1
REAC	REAC:R-HSA-376176	Signaling by ROBO receptors	Signaling by ROBO receptors	28	1.591019e-36	1
REAC	REAC:R-HSA-71291	Metabolism of amino acids and derivatives	Metabolism of amino acids and derivatives	28	5.134539e-30	1
REAC	REAC:R-HSA-9735869	SARS-CoV-1 modulates host translation machinery	SARS-CoV-1 modulates host translation machinery	15	6.585218e-26	1
REAC	REAC:R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	Formation of the ternary complex, and subsequently, the 43S complex	16	1.676025e-25	1
REAC	REAC:R-HSA-422475	Axon guidance	Axon guidance	28	4.690245e-25	1
REAC	REAC:R-HSA-8953854	Metabolism of RNA	Metabolism of RNA	30	6.476925e-25	1
REAC	REAC:R-HSA-9675108	Nervous system development	Nervous system development	28	1.656910e-24	1
REAC	REAC:R-HSA-72702	Ribosomal scanning and start codon recognition	Ribosomal scanning and start codon recognition	16	1.747863e-24	1
REAC	REAC:R-HSA-72649	Translation initiation complex formation	Translation initiation complex formation	16	1.747863e-24	1
REAC	REAC:R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	16	2.378328e-24	1
REAC	REAC:R-HSA-9754678	SARS-CoV-2 modulates host translation machinery	SARS-CoV-2 modulates host translation machinery	15	2.173595e-23	1
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	30	3.029863e-22	1
REAC	REAC:R-HSA-2262752	Cellular responses to stress	Cellular responses to stress	28	1.941582e-20	1
REAC	REAC:R-HSA-8953897	Cellular responses to stimuli	Cellular responses to stimuli	28	3.135892e-20	1
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	30	9.711845e-20	1
REAC	REAC:R-HSA-9692914	SARS-CoV-1-host interactions	SARS-CoV-1-host interactions	15	6.820540e-19	1
REAC	REAC:R-HSA-9678108	SARS-CoV-1 Infection	SARS-CoV-1 Infection	15	3.055208e-16	1
REAC	REAC:R-HSA-392499	Metabolism of proteins	Metabolism of proteins	34	3.229400e-16	1
REAC	REAC:R-HSA-1266738	Developmental Biology	Developmental Biology	29	3.800504e-15	1
REAC	REAC:R-HSA-9705683	SARS-CoV-2-host interactions	SARS-CoV-2-host interactions	15	5.684631e-14	1
REAC	REAC:R-HSA-1643685	Disease	Disease	30	7.411586e-13	1
REAC	REAC:R-HSA-9694516	SARS-CoV-2 Infection	SARS-CoV-2 Infection	15	2.012585e-11	1
REAC	REAC:R-HSA-1430728	Metabolism	Metabolism	29	3.081729e-10	1
REAC	REAC:R-HSA-9679506	SARS-CoV Infections	SARS-CoV Infections	16	9.466154e-10	1
REAC	REAC:R-HSA-9629569	Protein hydroxylation	Protein hydroxylation	4	2.850613e-04	1
REAC	REAC:R-HSA-163841	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	4	2.576289e-02	1

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP477	Cytoplasmic ribosomal proteins	Cytoplasmic ribosomal proteins	28	6.251443e-48	1

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	29	7.144871e-48	1
GO:BP	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	32	7.892229e-34	1
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	38	3.004721e-15	1
GO:BP	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	16	5.314733e-15	1
GO:BP	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	11	4.115489e-13	1
GO:BP	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	41	6.033305e-08	1
GO:BP	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	10	6.863752e-08	1
GO:BP	GO:0009059	macromolecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	41	3.260202e-07	1
GO:BP	GO:0016072	rRNA metabolic process	"The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732]	10	3.549158e-07	1
GO:BP	GO:0042255	ribosome assembly	"The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]	6	7.804684e-06	1
GO:BP	GO:0009058	biosynthetic process	"A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	41	1.423504e-05	1
GO:BP	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	42	1.526907e-04	1
GO:BP	GO:0022613	ribonucleoprotein complex biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah]	17	1.952904e-04	1
GO:BP	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]	42	3.831726e-04	1
GO:BP	GO:0140694	membraneless organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081]	9	4.920150e-04	1
GO:BP	GO:0000028	ribosomal small subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl, PMID:30467428]	3	1.353499e-02	1
GO:BP	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	4	2.803410e-02	1
GO:BP	GO:0034101	erythrocyte homeostasis	"Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397]	5	2.817877e-02	1
GO:BP	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	3	3.327173e-02	1

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:03010	Ribosome	Ribosome	28	3.642746e-40	1
KEGG	KEGG:05171	Coronavirus disease - COVID-19	Coronavirus disease - COVID-19	28	8.606612e-35	1

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:306	Ribosome, cytoplasmic	Ribosome, cytoplasmic	26	1.058173e-36	1
CORUM	CORUM:3055	Nop56p-associated pre-rRNA complex	Nop56p-associated pre-rRNA complex	22	2.743274e-25	1
CORUM	CORUM:338	40S ribosomal subunit, cytoplasmic	40S ribosomal subunit, cytoplasmic	14	1.098340e-19	1
CORUM	CORUM:305	40S ribosomal subunit, cytoplasmic	40S ribosomal subunit, cytoplasmic	14	3.715768e-19	1
CORUM	CORUM:308	60S ribosomal subunit, cytoplasmic	60S ribosomal subunit, cytoplasmic	12	5.315584e-13	1

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	28	8.080997e-33	1
GO:MF	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	40	4.928311e-25	1
GO:MF	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	28	7.131473e-22	1
GO:MF	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	41	7.452444e-17	1
GO:MF	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	7	7.127824e-08	1
GO:MF	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	7	1.096532e-02	1
GO:MF	GO:0070180	large ribosomal subunit rRNA binding	"Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh]	2	2.381282e-02	1
GO:MF	GO:0055106	ubiquitin-protein transferase regulator activity	"Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl]	3	2.645042e-02	1
GO:MF	GO:0008312	7S RNA binding	"Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]	2	4.986546e-02	1

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0012133	Erythroid hypoplasia	Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.	8	6.096014e-12	1
HP	HP:0030270	Elevated red cell adenosine deaminase activity	Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine.	7	3.229845e-10	1
HP	HP:0031640	Abnormal radial artery morphology	Any structural anomaly of the radial artery.	7	3.229845e-10	1
HP	HP:0020118	Radial artery aplasia	Congenital absence of the radial artery.	7	3.229845e-10	1
HP	HP:4000209	Abnormal erythrocyte adenosine deaminase activity	Activity of adenosine deaminase in red blood cells outside the limits of normal.	7	4.354257e-10	1
HP	HP:0012131	Abnormal number of erythroid precursors	A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.	8	5.666464e-10	1
HP	HP:0005532	Macrocytic dyserythropoietic anemia	Macrocytic dyserythropoietic anemia	7	5.797640e-10	1
HP	HP:0012410	Pure red cell aplasia	A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction.	7	9.940694e-10	1
HP	HP:0040276	Adenocarcinoma of the colon	Adenocarcinoma of the colon	7	3.260866e-09	1
HP	HP:0001227	Abnormality of the thenar eminence	An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb.	7	3.260866e-09	1
HP	HP:0006758	Malignant genitourinary tract tumor	The presence of a malignant neoplasm of the genital system.	7	4.042362e-09	1
HP	HP:0001894	Thrombocytosis	Increased numbers of platelets in the peripheral blood.	8	4.250505e-09	1
HP	HP:0011904	Persistence of hemoglobin F	Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent.	7	4.978670e-09	1
HP	HP:0001896	Reticulocytopenia	A reduced number of reticulocytes in the peripheral blood.	7	4.978670e-09	1
HP	HP:0002669	Osteosarcoma	A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor.	7	4.978670e-09	1
HP	HP:0002863	Myelodysplasia	Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.	9	5.856993e-09	1
HP	HP:0001895	Normochromic anemia	Normochromic anemia	7	7.417283e-09	1
HP	HP:0040275	Adenocarcinoma of the large intestine	A malignant epithelial tumor with a glandular organization that originates in the large intestine.	7	7.417283e-09	1
HP	HP:0001972	Macrocytic anemia	A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).	8	1.104349e-08	1
HP	HP:0009944	Partial duplication of thumb phalanx	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	7	1.295594e-08	1
HP	HP:0004808	Acute myeloid leukemia	A form of leukemia characterized by overproduction of an early myeloid cell.	8	1.378224e-08	1
HP	HP:0040273	Adenocarcinoma of the intestines	A malignant epithelial tumor with a glandular organization that originates in the intestines.	7	1.545368e-08	1
HP	HP:0009999	Partial duplication of the phalanx of hand	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	7	1.835185e-08	1
HP	HP:0030272	Abnormal erythrocyte enzyme concentration or activity	An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme.	7	4.085335e-08	1
HP	HP:0005518	Increased mean corpuscular volume	Larger than normal size of erythrocytes.	7	6.336167e-08	1
HP	HP:0000912	Sprengel anomaly	A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other).	7	8.364361e-08	1
HP	HP:0009777	Absent thumb	Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues.	7	1.412187e-07	1
HP	HP:0009942	Duplication of thumb phalanx	Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	7	1.808870e-07	1
HP	HP:0000185	Cleft soft palate	Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency.	7	1.808870e-07	1
HP	HP:0025065	Abnormal mean corpuscular volume	A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters.	7	2.297012e-07	1
HP	HP:0001790	Nonimmune hydrops fetalis	A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens .	7	3.617250e-07	1
HP	HP:0002488	Acute leukemia	A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).	8	5.433322e-07	1
HP	HP:0001199	Triphalangeal thumb	A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb.	7	5.537005e-07	1
HP	HP:0009778	Short thumb	Hypoplasia (congenital reduction in size) of the thumb.	8	8.625263e-07	1
HP	HP:0001087	Developmental glaucoma	Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma.	7	9.103996e-07	1
HP	HP:0006749	Malignant gastrointestinal tract tumors	Malignant gastrointestinal tract tumors	7	9.103996e-07	1
HP	HP:0002672	Gastrointestinal carcinoma	Gastrointestinal carcinoma	7	9.103996e-07	1
HP	HP:0011902	Abnormal hemoglobin	Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes.	7	1.099961e-06	1
HP	HP:0100273	Neoplasm of the colon	Neoplasm of the colon	7	1.726829e-06	1
HP	HP:0004312	Abnormal reticulocyte morphology	A reticulocyte abnormality.	7	2.051583e-06	1
HP	HP:0009601	Aplasia/Hypoplasia of the thumb	Hypoplastic/small or absent thumb.	8	3.320793e-06	1
HP	HP:0000294	Low anterior hairline	Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella.	8	3.503476e-06	1
HP	HP:0000085	Horseshoe kidney	A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline.	8	3.694830e-06	1
HP	HP:0009380	Finger aplasia	A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers).	7	3.923973e-06	1
HP	HP:0000980	Pallor	Abnormally pale skin.	8	4.554050e-06	1
HP	HP:0001882	Decreased total leukocyte count	An abnormal decreased number of leukocytes in the blood.	8	5.581811e-06	1
HP	HP:0010622	Neoplasm of the skeletal system	A tumor (abnormal growth of tissue) of the skeleton.	7	1.001094e-05	1
HP	HP:0001909	Leukemia	A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.	8	1.043942e-05	1
HP	HP:0001874	Abnormality of neutrophils	A neutrophil abnormality.	9	1.373578e-05	1
HP	HP:0100834	Neoplasm of the large intestine	The presence of a neoplasm of the large intestine.	7	1.900234e-05	1
HP	HP:0004377	Hematological neoplasm	Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue).	9	3.212018e-05	1
HP	HP:0000465	Webbed neck	Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline.	7	3.223718e-05	1
HP	HP:0010972	Anemia of inadequate production	A kind of anemia characterized by inadequate production of erythrocytes.	8	3.585778e-05	1
HP	HP:0001789	Hydrops fetalis	The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema.	7	3.810650e-05	1
HP	HP:0001421	Abnormality of the musculature of the hand	Abnormality of the musculature of the hand	7	4.025435e-05	1
HP	HP:0001875	Decreased total neutrophil count	Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group.	8	4.877019e-05	1
HP	HP:0001911	Abnormal granulocyte morphology	Any structural abnormality or abnormal count of granulocytes.	9	6.051976e-05	1
HP	HP:0000599	Abnormality of the frontal hairline	An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not.	8	6.794128e-05	1
HP	HP:0000519	Developmental cataract	A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens.	7	8.299628e-05	1
HP	HP:0011991	Abnormal total neutrophil count	A deviation from the normal range of neutrophil cell counts in the circulation.	8	9.659198e-05	1
HP	HP:0010974	Abnormal myeloid leukocyte morphology	An abnormality of myeloid leukocytes.	9	1.239142e-04	1
HP	HP:0001680	Coarctation of aorta	Coarctation of the aorta is a narrowing or constriction of a segment of the aorta.	7	1.457095e-04	1
HP	HP:0100542	Abnormal localization of kidney	An abnormal site of the kidney.	8	1.539541e-04	1
HP	HP:0100242	Sarcoma	A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant.	7	2.657563e-04	1
HP	HP:0032309	Abnormal granulocyte count	Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group.	8	3.715379e-04	1
HP	HP:0100736	Abnormal soft palate morphology	An abnormality of the soft palate.	8	3.823062e-04	1
HP	HP:0000782	Abnormal scapula morphology	Any abnormality of the scapula, also known as the shoulder blade.	7	4.607711e-04	1
HP	HP:0008551	Microtia	Underdevelopment of the external ear.	7	6.646620e-04	1
HP	HP:0009553	Abnormality of the hairline	The hairline refers to the outline of hair of the head. An abnormality of the hairline can refer to an unusually low or high border between areas of the scalp with and without hair or to abnormal projections of scalp hair.	8	7.547346e-04	1
HP	HP:0009602	Abnormality of thumb phalanx	A structural anomaly of one or more phalanges of the thumb.	7	9.723069e-04	1
HP	HP:0034058	Abnormal fetal morphology	Any structural anomaly of the fetus.	8	1.103021e-03	1
HP	HP:0000104	Renal agenesis	Agenesis, that is, failure of the kidney to develop during embryogenesis and development.	7	1.147589e-03	1
HP	HP:0008772	Aplasia/Hypoplasia of the external ear	The presence of aplasia or developmental hypoplasia of all or part of the external ear.	7	1.185666e-03	1
HP	HP:0011873	Abnormal platelet count	Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood.	9	1.478463e-03	1
HP	HP:0008771	Aplasia/Hypoplasia of the ear	The presence of aplasia or developmental hypoplasia of the ear.	7	1.483288e-03	1
HP	HP:0009381	Short finger	Abnormally short finger associated with developmental hypoplasia.	8	1.509049e-03	1
HP	HP:0011361	Congenital abnormal hair pattern	A congenital abnormality of the distribution of hair growth.	8	1.581711e-03	1
HP	HP:0011875	Abnormal platelet morphology	An anomaly in platelet form, ultrastructure, or intracellular organelles.	9	1.592839e-03	1
HP	HP:0000286	Epicanthus	A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus.	10	1.614045e-03	1
HP	HP:0410030	Cleft lip	A gap in the lip or lips.	7	1.786350e-03	1
HP	HP:0001903	Anemia	A reduction in erythrocytes volume or hemoglobin concentration.	10	2.021214e-03	1
HP	HP:0009997	Duplication of phalanx of hand	This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.	7	2.270310e-03	1
HP	HP:0007379	Neoplasm of the genitourinary tract	A tumor (abnormal growth of tissue) of the genitourinary system.	7	2.407205e-03	1
HP	HP:0004275	Duplication of hand bones	Duplication of hand bones	7	2.407205e-03	1
HP	HP:0009142	Duplication of bones involving the upper extremities	Duplication of bones involving the upper extremities	7	2.407205e-03	1
HP	HP:0001872	Abnormality of thrombocytes	An abnormality of platelets.	9	2.543381e-03	1
HP	HP:0011792	Neoplasm by histology	Neoplasm categorized according to type of histological abnormality.	8	3.027498e-03	1
HP	HP:0001254	Lethargy	A state of fatigue, either physical or mental slowness and sluggishness, with difficulties in initiating or performing simple tasks. Distinguished from apathy which implies indifference and a lack of desire or interest in the task. A person with lethargy may have the desire, but not the energy to engage in personal or socially relevant tasks.	7	3.673527e-03	1
HP	HP:0011893	Abnormal leukocyte count	Number of leukocytes per volume of blood beyond normal limits.	9	3.701929e-03	1
HP	HP:0001629	Ventricular septal defect	A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum.	9	4.021726e-03	1
HP	HP:0000431	Wide nasal bridge	Increased breadth of the nasal bridge (and with it, the nasal root).	9	4.021726e-03	1
HP	HP:0006265	Aplasia/Hypoplasia of fingers	Small/hypoplastic or absent/aplastic fingers.	8	4.143760e-03	1
HP	HP:0010720	Abnormal hair pattern	An abnormality of the distribution of hair growth.	8	4.586866e-03	1
HP	HP:0010438	Abnormal ventricular septum morphology	A structural abnormality of the interventricular septum.	9	4.811247e-03	1
HP	HP:0001877	Abnormal erythrocyte morphology	Any structural abnormality of erythrocytes (red-blood cells).	10	4.901235e-03	1
HP	HP:0001518	Small for gestational age	Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age.	7	6.677452e-03	1
HP	HP:0001172	Abnormal thumb morphology	An abnormal structure of the first digit of the hand.	8	6.920715e-03	1
HP	HP:0001679	Abnormal aortic morphology	An abnormality of the aorta.	8	8.349362e-03	1
HP	HP:0001446	Abnormality of the musculature of the upper limbs	Abnormality of the musculature of the upper limbs	7	9.580870e-03	1
HP	HP:0034057	Fetal anomaly	Structural or functional abnormalities of the fetus. Note that this section comprises terms that describe abnormalities that are specific to the fetus or differ from the corresponding general terms. A term from anywhere in the Human Phenotype Ontology can be applied to a fetus if appropriate.	9	1.065762e-02	1
HP	HP:0001873	Thrombocytopenia	A reduction in the number of circulating thrombocytes.	8	1.135901e-02	1
HP	HP:0000369	Low-set ears	Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear.	10	1.219192e-02	1
HP	HP:0007378	Neoplasm of the gastrointestinal tract	A tumor (abnormal growth of tissue) of the gastrointestinal tract.	7	1.289066e-02	1
HP	HP:0100037	Abnormality of the scalp hair	An abnormality of the hair of head.	8	1.376487e-02	1
HP	HP:0000218	High palate	Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective).	10	1.599463e-02	1
HP	HP:0001965	Abnormal scalp morphology	Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows.	8	1.833520e-02	1
HP	HP:0005280	Depressed nasal bridge	Posterior positioning of the nasal root in relation to the overall facial profile for age.	9	1.969047e-02	1
HP	HP:0007700	Ocular anterior segment dysgenesis	Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin.	7	2.431380e-02	1
HP	HP:0001881	Abnormal leukocyte morphology	An abnormality of leukocytes.	9	2.496681e-02	1
HP	HP:0010987	Abnormal cellular immune system morphology	An abnormality of the morphology or counts of the cells that make up the immune system.	9	2.496681e-02	1
HP	HP:0000316	Hypertelorism	Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes).	10	2.597567e-02	1
HP	HP:0032251	Abnormal immune system morphology	Abnormal immune system morphology	9	3.516642e-02	1
HP	HP:0008678	Renal hypoplasia/aplasia	Absence or underdevelopment of the kidney.	7	4.318412e-02	1
HP	HP:0034930	Digestive system neoplasm	A tumor (abnormal growth of tissue) of the digestive system.	7	4.478545e-02	1

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0350473	Pancreas; exocrine glandular cells[High]	Pancreas; exocrine glandular cells[High]	26	1.767354e-09	1
HPA	HPA:0600432	Tonsil; germinal center cells[≥Medium]	Tonsil; germinal center cells[≥Medium]	33	7.382378e-08	1
HPA	HPA:0630222	Cervix; squamous epithelial cells[≥Medium]	Cervix; squamous epithelial cells[≥Medium]	31	4.123129e-07	1
HPA	HPA:0100133	Cerebral cortex; neuronal cells[High]	Cerebral cortex; neuronal cells[High]	22	2.378572e-06	1
HPA	HPA:0310431	Lymph node; germinal center cells[≥Low]	Lymph node; germinal center cells[≥Low]	34	4.421280e-06	1
HPA	HPA:0090163	Cerebellum; Purkinje cells[High]	Cerebellum; Purkinje cells[High]	20	4.596968e-06	1
HPA	HPA:0250133	Hippocampus; neuronal cells[High]	Hippocampus; neuronal cells[High]	18	7.352883e-06	1
HPA	HPA:0620221	Vagina; squamous epithelial cells[≥Low]	Vagina; squamous epithelial cells[≥Low]	36	9.889075e-06	1
HPA	HPA:0620000	Vagina	Vagina	36	9.889075e-06	1
HPA	HPA:0610000	Urinary bladder	Urinary bladder	38	3.237040e-05	1
HPA	HPA:0610831	Urinary bladder; urothelial cells[≥Low]	Urinary bladder; urothelial cells[≥Low]	38	3.237040e-05	1
HPA	HPA:0190222	Esophagus; squamous epithelial cells[≥Medium]	Esophagus; squamous epithelial cells[≥Medium]	33	3.669477e-05	1
HPA	HPA:0160052	Endometrium 1; glandular cells[≥Medium]	Endometrium 1; glandular cells[≥Medium]	33	6.412023e-05	1
HPA	HPA:0250132	Hippocampus; neuronal cells[≥Medium]	Hippocampus; neuronal cells[≥Medium]	30	8.043755e-05	1
HPA	HPA:0190223	Esophagus; squamous epithelial cells[High]	Esophagus; squamous epithelial cells[High]	19	8.543652e-05	1
HPA	HPA:0420000	Salivary gland	Salivary gland	37	9.054858e-05	1
HPA	HPA:0420051	Salivary gland; glandular cells[≥Low]	Salivary gland; glandular cells[≥Low]	37	9.054858e-05	1
HPA	HPA:0600431	Tonsil; germinal center cells[≥Low]	Tonsil; germinal center cells[≥Low]	35	9.801196e-05	1
HPA	HPA:0170052	Endometrium 2; glandular cells[≥Medium]	Endometrium 2; glandular cells[≥Medium]	32	9.805019e-05	1
HPA	HPA:0050053	Breast; glandular cells[High]	Breast; glandular cells[High]	17	1.394155e-04	1
HPA	HPA:0310000	Lymph node	Lymph node	36	1.684077e-04	1
HPA	HPA:0100132	Cerebral cortex; neuronal cells[≥Medium]	Cerebral cortex; neuronal cells[≥Medium]	32	1.712801e-04	1
HPA	HPA:0170251	Endometrium 2; cells in endometrial stroma[≥Low]	Endometrium 2; cells in endometrial stroma[≥Low]	27	1.765712e-04	1
HPA	HPA:0080132	Caudate; neuronal cells[≥Medium]	Caudate; neuronal cells[≥Medium]	29	2.369303e-04	1
HPA	HPA:0630221	Cervix; squamous epithelial cells[≥Low]	Cervix; squamous epithelial cells[≥Low]	33	3.248343e-04	1
HPA	HPA:0170252	Endometrium 2; cells in endometrial stroma[≥Medium]	Endometrium 2; cells in endometrial stroma[≥Medium]	19	3.373285e-04	1
HPA	HPA:0420052	Salivary gland; glandular cells[≥Medium]	Salivary gland; glandular cells[≥Medium]	31	5.358164e-04	1
HPA	HPA:0620222	Vagina; squamous epithelial cells[≥Medium]	Vagina; squamous epithelial cells[≥Medium]	28	8.189420e-04	1
HPA	HPA:0400000	Rectum	Rectum	38	9.280699e-04	1
HPA	HPA:0090192	Cerebellum; cells in molecular layer[≥Medium]	Cerebellum; cells in molecular layer[≥Medium]	23	9.533292e-04	1
HPA	HPA:0630000	Cervix	Cervix	36	1.174366e-03	1
HPA	HPA:0090162	Cerebellum; Purkinje cells[≥Medium]	Cerebellum; Purkinje cells[≥Medium]	28	1.226226e-03	1
HPA	HPA:0350471	Pancreas; exocrine glandular cells[≥Low]	Pancreas; exocrine glandular cells[≥Low]	36	1.279425e-03	1
HPA	HPA:0600433	Tonsil; germinal center cells[High]	Tonsil; germinal center cells[High]	15	1.285542e-03	1
HPA	HPA:0210000	Fallopian tube	Fallopian tube	37	1.476685e-03	1
HPA	HPA:0380000	Placenta	Placenta	37	1.832940e-03	1
HPA	HPA:0160252	Endometrium 1; cells in endometrial stroma[≥Medium]	Endometrium 1; cells in endometrial stroma[≥Medium]	20	2.026441e-03	1
HPA	HPA:0600223	Tonsil; squamous epithelial cells[High]	Tonsil; squamous epithelial cells[High]	16	2.442737e-03	1
HPA	HPA:0600221	Tonsil; squamous epithelial cells[≥Low]	Tonsil; squamous epithelial cells[≥Low]	35	2.552869e-03	1
HPA	HPA:0420053	Salivary gland; glandular cells[High]	Salivary gland; glandular cells[High]	16	2.666572e-03	1
HPA	HPA:0340461	Ovary; ovarian stroma cells[≥Low]	Ovary; ovarian stroma cells[≥Low]	27	2.698755e-03	1
HPA	HPA:0530722	Spleen; cells in white pulp[≥Medium]	Spleen; cells in white pulp[≥Medium]	22	2.703334e-03	1
HPA	HPA:0030053	Appendix; glandular cells[High]	Appendix; glandular cells[High]	18	3.100983e-03	1
HPA	HPA:0430052	Seminal vesicle; glandular cells[≥Medium]	Seminal vesicle; glandular cells[≥Medium]	31	3.332382e-03	1
HPA	HPA:0170053	Endometrium 2; glandular cells[High]	Endometrium 2; glandular cells[High]	15	3.523123e-03	1
HPA	HPA:0600222	Tonsil; squamous epithelial cells[≥Medium]	Tonsil; squamous epithelial cells[≥Medium]	30	3.862375e-03	1
HPA	HPA:0530721	Spleen; cells in white pulp[≥Low]	Spleen; cells in white pulp[≥Low]	28	3.925075e-03	1
HPA	HPA:0350472	Pancreas; exocrine glandular cells[≥Medium]	Pancreas; exocrine glandular cells[≥Medium]	31	4.631345e-03	1
HPA	HPA:0630223	Cervix; squamous epithelial cells[High]	Cervix; squamous epithelial cells[High]	13	5.033688e-03	1
HPA	HPA:0160051	Endometrium 1; glandular cells[≥Low]	Endometrium 1; glandular cells[≥Low]	35	5.526580e-03	1
HPA	HPA:0430000	Seminal vesicle	Seminal vesicle	35	5.728672e-03	1
HPA	HPA:0430051	Seminal vesicle; glandular cells[≥Low]	Seminal vesicle; glandular cells[≥Low]	35	5.728672e-03	1
HPA	HPA:0600000	Tonsil	Tonsil	37	6.434471e-03	1
HPA	HPA:0550053	Stomach 2; glandular cells[High]	Stomach 2; glandular cells[High]	20	7.429294e-03	1
HPA	HPA:0600441	Tonsil; non-germinal center cells[≥Low]	Tonsil; non-germinal center cells[≥Low]	33	8.252542e-03	1
HPA	HPA:0390052	Prostate; glandular cells[≥Medium]	Prostate; glandular cells[≥Medium]	29	8.834640e-03	1
HPA	HPA:0480000	Small intestine	Small intestine	37	9.523594e-03	1
HPA	HPA:0080131	Caudate; neuronal cells[≥Low]	Caudate; neuronal cells[≥Low]	33	9.726215e-03	1
HPA	HPA:0350000	Pancreas	Pancreas	36	1.051830e-02	1
HPA	HPA:0080000	Caudate	Caudate	35	1.054848e-02	1
HPA	HPA:0250131	Hippocampus; neuronal cells[≥Low]	Hippocampus; neuronal cells[≥Low]	33	1.276757e-02	1
HPA	HPA:0620223	Vagina; squamous epithelial cells[High]	Vagina; squamous epithelial cells[High]	13	1.386713e-02	1
HPA	HPA:0160000	Endometrium 1	Endometrium 1	35	1.563232e-02	1
HPA	HPA:0330223	Oral mucosa; squamous epithelial cells[High]	Oral mucosa; squamous epithelial cells[High]	13	1.575181e-02	1
HPA	HPA:0390051	Prostate; glandular cells[≥Low]	Prostate; glandular cells[≥Low]	34	1.725982e-02	1
HPA	HPA:0390000	Prostate	Prostate	34	1.725982e-02	1
HPA	HPA:0160251	Endometrium 1; cells in endometrial stroma[≥Low]	Endometrium 1; cells in endometrial stroma[≥Low]	26	1.751460e-02	1
HPA	HPA:0190221	Esophagus; squamous epithelial cells[≥Low]	Esophagus; squamous epithelial cells[≥Low]	34	1.755663e-02	1
HPA	HPA:0190000	Esophagus	Esophagus	34	1.755663e-02	1
HPA	HPA:0610832	Urinary bladder; urothelial cells[≥Medium]	Urinary bladder; urothelial cells[≥Medium]	32	1.888120e-02	1
HPA	HPA:0210052	Fallopian tube; glandular cells[≥Medium]	Fallopian tube; glandular cells[≥Medium]	28	1.942973e-02	1
HPA	HPA:0100131	Cerebral cortex; neuronal cells[≥Low]	Cerebral cortex; neuronal cells[≥Low]	34	2.002659e-02	1
HPA	HPA:0170051	Endometrium 2; glandular cells[≥Low]	Endometrium 2; glandular cells[≥Low]	34	2.133666e-02	1
HPA	HPA:0540052	Stomach 1; glandular cells[≥Medium]	Stomach 1; glandular cells[≥Medium]	33	2.183093e-02	1
HPA	HPA:0380521	Placenta; trophoblastic cells[≥Low]	Placenta; trophoblastic cells[≥Low]	33	2.267655e-02	1
HPA	HPA:0500111	Soft tissue 1; chondrocytes[≥Low]	Soft tissue 1; chondrocytes[≥Low]	18	2.522572e-02	1
HPA	HPA:0630051	Cervix; glandular cells[≥Low]	Cervix; glandular cells[≥Low]	31	2.625941e-02	1
HPA	HPA:0310441	Lymph node; non-germinal center cells[≥Low]	Lymph node; non-germinal center cells[≥Low]	32	2.970769e-02	1
HPA	HPA:0220051	Gallbladder; glandular cells[≥Low]	Gallbladder; glandular cells[≥Low]	36	3.088202e-02	1
HPA	HPA:0220000	Gallbladder	Gallbladder	36	3.088202e-02	1
HPA	HPA:0600442	Tonsil; non-germinal center cells[≥Medium]	Tonsil; non-germinal center cells[≥Medium]	26	3.100516e-02	1
HPA	HPA:0540000	Stomach 1	Stomach 1	36	3.140208e-02	1
HPA	HPA:0540051	Stomach 1; glandular cells[≥Low]	Stomach 1; glandular cells[≥Low]	36	3.140208e-02	1
HPA	HPA:0210051	Fallopian tube; glandular cells[≥Low]	Fallopian tube; glandular cells[≥Low]	31	3.256521e-02	1
HPA	HPA:0050052	Breast; glandular cells[≥Medium]	Breast; glandular cells[≥Medium]	29	3.357484e-02	1
HPA	HPA:0380511	Placenta; decidual cells[≥Low]	Placenta; decidual cells[≥Low]	28	3.996247e-02	1
HPA	HPA:0500652	Soft tissue 1; fibroblasts[≥Medium]	Soft tissue 1; fibroblasts[≥Medium]	20	4.195102e-02	1
HPA	HPA:0080133	Caudate; neuronal cells[High]	Caudate; neuronal cells[High]	12	4.683817e-02	1
HPA	HPA:0290402	Liver; hepatocytes[≥Medium]	Liver; hepatocytes[≥Medium]	24	4.696498e-02	1
HPA	HPA:0170000	Endometrium 2	Endometrium 2	34	4.732454e-02	1
HPA	HPA:0180000	Epididymis	Epididymis	35	4.994090e-02	1
HPA	HPA:0180051	Epididymis; glandular cells[≥Low]	Epididymis; glandular cells[≥Low]	35	4.994090e-02	1

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-16-5p	hsa-mir-16-5p	hsa-mir-16-5p	16	0.000459	1
MIRNA	MIRNA:hsa-mir-92a-3p	hsa-mir-92a-3p	hsa-mir-92a-3p	14	0.003084	1
MIRNA	MIRNA:hsa-mir-1180-3p	hsa-mir-1180-3p	hsa-mir-1180-3p	4	0.012717	1
MIRNA	MIRNA:hsa-mir-652-3p	hsa-mir-652-3p	hsa-mir-652-3p	5	0.015747	1
MIRNA	MIRNA:hsa-mir-615-3p	hsa-mir-615-3p	hsa-mir-615-3p	11	0.018350	1

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M08298_1	Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1	Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1	22	0.020565	1
TF	TF:M01770	Factor: XBP-1; motif: WNNGMCACGTC	Factor: XBP-1; motif: WNNGMCACGTC	39	0.026513	1

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0008540	proteasome regulatory particle, base subcomplex	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	4	6.417044e-09	2
GO:CC	GO:0000502	proteasome complex	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome]	5	5.552028e-08	2
GO:CC	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	4	9.448753e-08	2
GO:CC	GO:0022624	proteasome accessory complex	"A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu]	4	1.632224e-07	2
GO:CC	GO:1905369	endopeptidase complex	"A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]	5	4.501321e-07	2
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	14	4.751893e-07	2
GO:CC	GO:1905368	peptidase complex	"A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]	5	1.610730e-06	2
GO:CC	GO:0034515	proteasome storage granule	"An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:krc, GOC:rb, PMID:18504300, PMID:30204036]	2	4.830828e-05	2
GO:CC	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	7	8.708500e-05	2
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	10	2.517847e-03	2
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	8	6.389884e-03	2
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	8	6.500650e-03	2
GO:CC	GO:0099524	postsynaptic cytosol	"The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos]	2	1.322754e-02	2
GO:CC	GO:0099522	cytosolic region	"Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos]	2	3.006272e-02	2
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	14	4.448042e-02	2
GO:CC	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	10	4.450586e-02	2

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	AUF1 (hnRNP D0) binds and destabilizes mRNA	5	0.000001	2
REAC	REAC:R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	5	0.000004	2
REAC	REAC:R-HSA-1234174	Cellular response to hypoxia	Cellular response to hypoxia	5	0.000008	2
REAC	REAC:R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	Regulation of mRNA stability by proteins that bind AU-rich elements	5	0.000016	2
REAC	REAC:R-HSA-376176	Signaling by ROBO receptors	Signaling by ROBO receptors	6	0.000046	2
REAC	REAC:R-HSA-5610787	Hedgehog 'off' state	Hedgehog 'off' state	5	0.000062	2
REAC	REAC:R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	Cross-presentation of soluble exogenous antigens (endosomes)	4	0.000107	2
REAC	REAC:R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	Regulation of activated PAK-2p34 by proteasome mediated degradation	4	0.000116	2
REAC	REAC:R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	Regulation of ornithine decarboxylase (ODC)	4	0.000126	2
REAC	REAC:R-HSA-69610	p53-Independent DNA Damage Response	p53-Independent DNA Damage Response	4	0.000136	2
REAC	REAC:R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	4	0.000136	2
REAC	REAC:R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	Ubiquitin-dependent degradation of Cyclin D	4	0.000136	2
REAC	REAC:R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	p53-Independent G1/S DNA damage checkpoint	4	0.000136	2
REAC	REAC:R-HSA-9762114	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	4	0.000136	2
REAC	REAC:R-HSA-180534	Vpu mediated degradation of CD4	Vpu mediated degradation of CD4	4	0.000136	2
REAC	REAC:R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	Autodegradation of the E3 ubiquitin ligase COP1	4	0.000136	2
REAC	REAC:R-HSA-180585	Vif-mediated degradation of APOBEC3G	Vif-mediated degradation of APOBEC3G	4	0.000148	2
REAC	REAC:R-HSA-169911	Regulation of Apoptosis	Regulation of Apoptosis	4	0.000148	2
REAC	REAC:R-HSA-9604323	Negative regulation of NOTCH4 signaling	Negative regulation of NOTCH4 signaling	4	0.000148	2
REAC	REAC:R-HSA-8941858	Regulation of RUNX3 expression and activity	Regulation of RUNX3 expression and activity	4	0.000172	2
REAC	REAC:R-HSA-4641257	Degradation of AXIN	Degradation of AXIN	4	0.000172	2
REAC	REAC:R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	4	0.000172	2
REAC	REAC:R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	SCF-beta-TrCP mediated degradation of Emi1	4	0.000172	2
REAC	REAC:R-HSA-9824272	Somitogenesis	Somitogenesis	4	0.000172	2
REAC	REAC:R-HSA-5362768	Hh mutants are degraded by ERAD	Hh mutants are degraded by ERAD	4	0.000185	2
REAC	REAC:R-HSA-69541	Stabilization of p53	Stabilization of p53	4	0.000198	2
REAC	REAC:R-HSA-4641258	Degradation of DVL	Degradation of DVL	4	0.000198	2
REAC	REAC:R-HSA-351202	Metabolism of polyamines	Metabolism of polyamines	4	0.000213	2
REAC	REAC:R-HSA-5676590	NIK-->noncanonical NF-kB signaling	NIK-->noncanonical NF-kB signaling	4	0.000228	2
REAC	REAC:R-HSA-5387390	Hh mutants abrogate ligand secretion	Hh mutants abrogate ligand secretion	4	0.000228	2
REAC	REAC:R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	GLI3 is processed to GLI3R by the proteasome	4	0.000244	2
REAC	REAC:R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	SCF(Skp2)-mediated degradation of p27/p21	4	0.000244	2
REAC	REAC:R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	Dectin-1 mediated noncanonical NF-kB signaling	4	0.000244	2
REAC	REAC:R-HSA-5610783	Degradation of GLI2 by the proteasome	Degradation of GLI2 by the proteasome	4	0.000244	2
REAC	REAC:R-HSA-5610780	Degradation of GLI1 by the proteasome	Degradation of GLI1 by the proteasome	4	0.000244	2
REAC	REAC:R-HSA-5358351	Signaling by Hedgehog	Signaling by Hedgehog	5	0.000246	2
REAC	REAC:R-HSA-5678895	Defective CFTR causes cystic fibrosis	Defective CFTR causes cystic fibrosis	4	0.000261	2
REAC	REAC:R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	Autodegradation of Cdh1 by Cdh1:APC/C	4	0.000318	2
REAC	REAC:R-HSA-4608870	Asymmetric localization of PCP proteins	Asymmetric localization of PCP proteins	4	0.000318	2
REAC	REAC:R-HSA-5358346	Hedgehog ligand biogenesis	Hedgehog ligand biogenesis	4	0.000338	2
REAC	REAC:R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	p53-Dependent G1/S DNA damage checkpoint	4	0.000360	2
REAC	REAC:R-HSA-69563	p53-Dependent G1 DNA Damage Response	p53-Dependent G1 DNA Damage Response	4	0.000360	2
REAC	REAC:R-HSA-5658442	Regulation of RAS by GAPs	Regulation of RAS by GAPs	4	0.000382	2
REAC	REAC:R-HSA-1169091	Activation of NF-kappaB in B cells	Activation of NF-kappaB in B cells	4	0.000382	2
REAC	REAC:R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	APC/C:Cdc20 mediated degradation of Securin	4	0.000406	2
REAC	REAC:R-HSA-69615	G1/S DNA Damage Checkpoints	G1/S DNA Damage Checkpoints	4	0.000406	2
REAC	REAC:R-HSA-8948751	Regulation of PTEN stability and activity	Regulation of PTEN stability and activity	4	0.000430	2
REAC	REAC:R-HSA-9793380	Formation of paraxial mesoderm	Formation of paraxial mesoderm	4	0.000430	2
REAC	REAC:R-HSA-68949	Orc1 removal from chromatin	Orc1 removal from chromatin	4	0.000483	2
REAC	REAC:R-HSA-8939902	Regulation of RUNX2 expression and activity	Regulation of RUNX2 expression and activity	4	0.000483	2
REAC	REAC:R-HSA-9010553	Regulation of expression of SLITs and ROBOs	Regulation of expression of SLITs and ROBOs	5	0.000487	2
REAC	REAC:R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	CDK-mediated phosphorylation and removal of Cdc6	4	0.000540	2
REAC	REAC:R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	4	0.000540	2
REAC	REAC:R-HSA-422475	Axon guidance	Axon guidance	7	0.000553	2
REAC	REAC:R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	4	0.000571	2
REAC	REAC:R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	4	0.000571	2
REAC	REAC:R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	APC/C:Cdc20 mediated degradation of mitotic proteins	4	0.000636	2
REAC	REAC:R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	4	0.000670	2
REAC	REAC:R-HSA-5619084	ABC transporter disorders	ABC transporter disorders	4	0.000706	2
REAC	REAC:R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	The role of GTSE1 in G2/M progression after G2 checkpoint	4	0.000743	2
REAC	REAC:R-HSA-9675108	Nervous system development	Nervous system development	7	0.000749	2
REAC	REAC:R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	Downstream signaling events of B Cell Receptor (BCR)	4	0.000781	2
REAC	REAC:R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	Regulation of APC/C activators between G1/S and early anaphase	4	0.000821	2
REAC	REAC:R-HSA-9013694	Signaling by NOTCH4	Signaling by NOTCH4	4	0.000821	2
REAC	REAC:R-HSA-69202	Cyclin E associated events during G1/S transition	Cyclin E associated events during G1/S transition	4	0.000863	2
REAC	REAC:R-HSA-195253	Degradation of beta-catenin by the destruction complex	Degradation of beta-catenin by the destruction complex	4	0.000906	2
REAC	REAC:R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	Cyclin A:Cdk2-associated events at S phase entry	4	0.000950	2
REAC	REAC:R-HSA-5632684	Hedgehog 'on' state	Hedgehog 'on' state	4	0.000997	2
REAC	REAC:R-HSA-453276	Regulation of mitotic cell cycle	Regulation of mitotic cell cycle	4	0.001145	2
REAC	REAC:R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	APC/C-mediated degradation of cell cycle proteins	4	0.001145	2
REAC	REAC:R-HSA-5687128	MAPK6/MAPK4 signaling	MAPK6/MAPK4 signaling	4	0.001198	2
REAC	REAC:R-HSA-1236974	ER-Phagosome pathway	ER-Phagosome pathway	4	0.001253	2
REAC	REAC:R-HSA-69052	Switching of origins to a post-replicative state	Switching of origins to a post-replicative state	4	0.001368	2
REAC	REAC:R-HSA-4086400	PCP/CE pathway	PCP/CE pathway	4	0.001368	2
REAC	REAC:R-HSA-9759194	Nuclear events mediated by NFE2L2	Nuclear events mediated by NFE2L2	4	0.001555	2
REAC	REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	Transcriptional regulation by RUNX3	4	0.001555	2
REAC	REAC:R-HSA-5607764	CLEC7A (Dectin-1) signaling	CLEC7A (Dectin-1) signaling	4	0.001690	2
REAC	REAC:R-HSA-202424	Downstream TCR signaling	Downstream TCR signaling	4	0.001761	2
REAC	REAC:R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TNFR2 non-canonical NF-kB pathway	4	0.001909	2
REAC	REAC:R-HSA-162906	HIV Infection	HIV Infection	5	0.001916	2
REAC	REAC:R-HSA-5689603	UCH proteinases	UCH proteinases	4	0.002066	2
REAC	REAC:R-HSA-382556	ABC-family proteins mediated transport	ABC-family proteins mediated transport	4	0.002148	2
REAC	REAC:R-HSA-1236975	Antigen processing-Cross presentation	Antigen processing-Cross presentation	4	0.002319	2
REAC	REAC:R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	Diseases of signal transduction by growth factor receptors and second messengers	6	0.003028	2
REAC	REAC:R-HSA-9020702	Interleukin-1 signaling	Interleukin-1 signaling	4	0.003105	2
REAC	REAC:R-HSA-8878166	Transcriptional regulation by RUNX2	Transcriptional regulation by RUNX2	4	0.003687	2
REAC	REAC:R-HSA-202403	TCR signaling	TCR signaling	4	0.003941	2
REAC	REAC:R-HSA-69239	Synthesis of DNA	Synthesis of DNA	4	0.004073	2
REAC	REAC:R-HSA-9755511	KEAP1-NFE2L2 pathway	KEAP1-NFE2L2 pathway	4	0.004487	2
REAC	REAC:R-HSA-9758941	Gastrulation	Gastrulation	4	0.004632	2
REAC	REAC:R-HSA-162909	Host Interactions of HIV factors	Host Interactions of HIV factors	4	0.004933	2
REAC	REAC:R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	RUNX1 regulates transcription of genes involved in differentiation of HSCs	4	0.005247	2
REAC	REAC:R-HSA-69206	G1/S Transition	G1/S Transition	4	0.005576	2
REAC	REAC:R-HSA-5621481	C-type lectin receptors (CLRs)	C-type lectin receptors (CLRs)	4	0.006465	2
REAC	REAC:R-HSA-2871837	FCERI mediated NF-kB activation	FCERI mediated NF-kB activation	4	0.006465	2
REAC	REAC:R-HSA-9006925	Intracellular signaling by second messengers	Intracellular signaling by second messengers	5	0.006659	2
REAC	REAC:R-HSA-6807070	PTEN Regulation	PTEN Regulation	4	0.006848	2
REAC	REAC:R-HSA-68867	Assembly of the pre-replicative complex	Assembly of the pre-replicative complex	4	0.007664	2
REAC	REAC:R-HSA-3858494	Beta-catenin independent WNT signaling	Beta-catenin independent WNT signaling	4	0.007879	2
REAC	REAC:R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation	5	0.008614	2
REAC	REAC:R-HSA-453279	Mitotic G1 phase and G1/S transition	Mitotic G1 phase and G1/S transition	4	0.009020	2
REAC	REAC:R-HSA-446652	Interleukin-1 family signaling	Interleukin-1 family signaling	4	0.009760	2
REAC	REAC:R-HSA-69002	DNA Replication Pre-Initiation	DNA Replication Pre-Initiation	4	0.011953	2
REAC	REAC:R-HSA-69242	S Phase	S Phase	4	0.012862	2
REAC	REAC:R-HSA-983705	Signaling by the B Cell Receptor (BCR)	Signaling by the B Cell Receptor (BCR)	4	0.013176	2
REAC	REAC:R-HSA-69481	G2/M Checkpoints	G2/M Checkpoints	4	0.014488	2
REAC	REAC:R-HSA-5619115	Disorders of transmembrane transporters	Disorders of transmembrane transporters	4	0.016633	2
REAC	REAC:R-HSA-109581	Apoptosis	Apoptosis	4	0.017788	2
REAC	REAC:R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	Fc epsilon receptor (FCERI) signaling	4	0.020274	2
REAC	REAC:R-HSA-69306	DNA Replication	DNA Replication	4	0.022533	2
REAC	REAC:R-HSA-2467813	Separation of Sister Chromatids	Separation of Sister Chromatids	4	0.023006	2
REAC	REAC:R-HSA-983169	Class I MHC mediated antigen processing & presentation	Class I MHC mediated antigen processing & presentation	5	0.023567	2
REAC	REAC:R-HSA-69275	G2/M Transition	G2/M Transition	4	0.027056	2
REAC	REAC:R-HSA-453274	Mitotic G2-G2/M phases	Mitotic G2-G2/M phases	4	0.028145	2
REAC	REAC:R-HSA-1643685	Disease	Disease	9	0.028930	2
REAC	REAC:R-HSA-5357801	Programmed Cell Death	Programmed Cell Death	4	0.034075	2
REAC	REAC:R-HSA-9711123	Cellular response to chemical stress	Cellular response to chemical stress	4	0.035363	2
REAC	REAC:R-HSA-5689880	Ub-specific processing proteases	Ub-specific processing proteases	4	0.043088	2
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	7	0.045446	2
REAC	REAC:R-HSA-68882	Mitotic Anaphase	Mitotic Anaphase	4	0.048603	2
REAC	REAC:R-HSA-2555396	Mitotic Metaphase and Anaphase	Mitotic Metaphase and Anaphase	4	0.049430	2

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:32	PA700 complex	PA700 complex	4	0.000020	2
CORUM	CORUM:193	PA700-20S-PA28 complex	PA700-20S-PA28 complex	4	0.000163	2

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	9	0.000032	2
GO:MF	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	9	0.000052	2
GO:MF	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	10	0.000153	2
GO:MF	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	10	0.000243	2
GO:MF	GO:0120544	polypeptide conformation or assembly isomerase activity	"Catalysis of a reaction that alters the conformation or assembly of a polypeptide." [EC:5.6.1.-]	4	0.000283	2
GO:MF	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	8	0.000472	2
GO:MF	GO:0032555	purine ribonucleotide binding	"Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	9	0.000496	2
GO:MF	GO:0032553	ribonucleotide binding	"Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	9	0.000530	2
GO:MF	GO:0017076	purine nucleotide binding	"Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]	9	0.000713	2
GO:MF	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	9	0.001298	2
GO:MF	GO:1901265	nucleoside phosphate binding	"Binding to nucleoside phosphate." [GOC:TermGenie]	9	0.001382	2
GO:MF	GO:0036402	proteasome-activating activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome." [GOC:rb, PMID:11430818]	2	0.001622	2
GO:MF	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	9	0.002020	2
GO:MF	GO:0035639	purine ribonucleoside triphosphate binding	"Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732]	8	0.005204	2
GO:MF	GO:0120543	macromolecular conformation isomerase activity	"Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-]	4	0.008989	2
GO:MF	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	5	0.010769	2

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:03050	Proteasome	Proteasome	4	0.000042	2
KEGG	KEGG:05012	Parkinson disease	Parkinson disease	5	0.002623	2
KEGG	KEGG:05020	Prion disease	Prion disease	5	0.002920	2
KEGG	KEGG:05017	Spinocerebellar ataxia	Spinocerebellar ataxia	4	0.003708	2
KEGG	KEGG:05016	Huntington disease	Huntington disease	5	0.005135	2
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	Amyotrophic lateral sclerosis	5	0.011695	2
KEGG	KEGG:05169	Epstein-Barr virus infection	Epstein-Barr virus infection	4	0.013827	2
KEGG	KEGG:05010	Alzheimer disease	Alzheimer disease	5	0.014855	2
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	Pathways of neurodegeneration - multiple diseases	5	0.040380	2

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP183	Proteasome degradation	Proteasome degradation	4	0.000146	2
WP	WP:WP2359	Parkin ubiquitin proteasomal system pathway	Parkin ubiquitin proteasomal system pathway	4	0.000253	2
WP	WP:WP5124	Alzheimer 39 s disease	Alzheimer 39 s disease	5	0.002003	2
WP	WP:WP2059	Alzheimer 39 s disease and miRNA effects	Alzheimer 39 s disease and miRNA effects	5	0.002197	2

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	5	0.006573	2
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	8	0.008792	2
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	11	0.017433	2
GO:BP	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	5	0.024490	2
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	6	0.040480	2
GO:BP	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	5	0.049257	2

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0030071	Appendix; lymphoid tissue[≥Low]	Appendix; lymphoid tissue[≥Low]	11	0.011809	2
HPA	HPA:0190223	Esophagus; squamous epithelial cells[High]	Esophagus; squamous epithelial cells[High]	7	0.041241	2

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	7	0.000776	3
GO:CC	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	4	0.004427	3
GO:CC	GO:0005912	adherens junction	"A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]	3	0.006077	3
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	6	0.012445	3
GO:CC	GO:0014704	intercalated disc	"A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910]	2	0.024581	3
GO:CC	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	4	0.033505	3
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	4	0.037441	3

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0071896	protein localization to adherens junction	"Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237]	2	0.003547	3
GO:BP	GO:0043297	apical junction assembly	"The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556]	3	0.006469	3
GO:BP	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	6	0.008188	3
GO:BP	GO:0030855	epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]	5	0.014014	3
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]	3	0.021627	3

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0008013	beta-catenin binding	"Binding to a catenin beta subunit." [GOC:bf]	3	0.004703	3

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04390	Hippo signaling pathway	Hippo signaling pathway	3	0.010003	3

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-615-3p	hsa-mir-615-3p	hsa-mir-615-3p	5	0.049823	3

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-320d	hsa-mir-320d	hsa-mir-320d	5	0.023263	4
MIRNA	MIRNA:hsa-mir-4429	hsa-mir-4429	hsa-mir-4429	5	0.023350	4
MIRNA	MIRNA:hsa-mir-320c	hsa-mir-320c	hsa-mir-320c	5	0.024962	4
MIRNA	MIRNA:hsa-mir-320b	hsa-mir-320b	hsa-mir-320b	5	0.028247	4

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0460202	Skin 1; endothelial cells[≥Medium]	Skin 1; endothelial cells[≥Medium]	4	0.024480	4
HPA	HPA:0470202	Skin 2; endothelial cells[≥Medium]	Skin 2; endothelial cells[≥Medium]	4	0.032308	4

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP3965	Lipid metabolism pathway	Lipid metabolism pathway	2	0.026109	4

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0004312	fatty acid synthase activity	"Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]	1	0.049963	4
GO:MF	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [RHEA:41788]	1	0.049963	4
GO:MF	GO:0031177	phosphopantetheine binding	"Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [GOC:mah, GOC:vw]	1	0.049963	4
GO:MF	GO:0140778	microtubule stabilizing activity	"A protein-containing complex stabilizing activity that prevents dissociation of microtubules." [PMID:34970964]	1	0.049963	4

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	5	0.000038	5
GO:BP	GO:0016072	rRNA metabolic process	"The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732]	5	0.000087	5
GO:BP	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	5	0.000228	5
GO:BP	GO:0022613	ribonucleoprotein complex biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah]	7	0.004422	5
GO:BP	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	3	0.004849	5
GO:BP	GO:0032774	RNA biosynthetic process	"The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]	10	0.011963	5
GO:BP	GO:0141187	nucleic acid biosynthetic process	"The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb]	10	0.014111	5
GO:BP	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	8	0.014920	5
GO:BP	GO:0016070	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	10	0.016124	5
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	10	0.021576	5
GO:BP	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	"Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]	2	0.028307	5
GO:BP	GO:0090304	nucleic acid metabolic process	"Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb]	10	0.035356	5

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	9	0.000070	5
GO:MF	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	9	0.009836	5

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	7	0.000475	5
GO:CC	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	10	0.041974	5

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP2363	Gastric cancer network 2	Gastric cancer network 2	2	0.002373	5

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:3055	Nop56p-associated pre-rRNA complex	Nop56p-associated pre-rRNA complex	3	0.003315	5

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0080133	Caudate; neuronal cells[High]	Caudate; neuronal cells[High]	5	0.01719	5

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	7	1.540332e-07	6
GO:BP	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	7	2.197282e-06	6
GO:BP	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	7	4.462676e-06	6
GO:BP	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	7	2.883021e-04	6
GO:BP	GO:0051052	regulation of DNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]	5	4.098934e-04	6
GO:BP	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	4	2.245393e-03	6
GO:BP	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	5	2.572343e-03	6
GO:BP	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	4	3.613706e-03	6
GO:BP	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	5	6.815797e-03	6
GO:BP	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194]	5	7.123550e-03	6
GO:BP	GO:0000727	double-strand break repair via break-induced replication	"The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]	2	8.692439e-03	6
GO:BP	GO:0006275	regulation of DNA replication	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]	3	1.035716e-02	6
GO:BP	GO:0030174	regulation of DNA-templated DNA replication initiation	"Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah]	2	1.382099e-02	6
GO:BP	GO:0044027	negative regulation of gene expression via chromosomal CpG island methylation	"An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes." [PMID:11898023, Wikipedia:Cpg_island]	2	1.382099e-02	6
GO:BP	GO:1902969	mitotic DNA replication	"Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]	2	1.789466e-02	6
GO:BP	GO:0045945	positive regulation of transcription by RNA polymerase III	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators, GOC:txnOH]	2	2.249134e-02	6
GO:BP	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	3	3.970579e-02	6
GO:BP	GO:0000725	recombinational repair	"A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh]	3	4.293822e-02	6
GO:BP	GO:0045814	negative regulation of gene expression, epigenetic	"An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696]	3	4.774802e-02	6

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	8	6.051591e-07	6
GO:CC	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	8	2.548675e-04	6
GO:CC	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	3	2.849455e-04	6
GO:CC	GO:0000792	heterochromatin	"A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156]	3	3.871983e-04	6
GO:CC	GO:0110016	B-WICH complex	"A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself." [GOC:bhm, PMID:16603771, PMID:21559432, PMID:23555303, PMID:26044184]	2	4.410097e-04	6
GO:CC	GO:0071162	CMG complex	"A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417]	2	8.657998e-04	6
GO:CC	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	2	8.657998e-04	6
GO:CC	GO:0098687	chromosomal region	"Any subdivision of a chromosome along its length." [GOC:dos]	4	9.950702e-04	6
GO:CC	GO:0031261	DNA replication preinitiation complex	"A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184]	2	1.227418e-03	6
GO:CC	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	8	2.107947e-03	6
GO:CC	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	5	6.687455e-03	6
GO:CC	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	3	8.769483e-03	6
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	8	9.303346e-03	6
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	8	9.314518e-03	6
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	8	9.597656e-03	6
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	8	9.597656e-03	6
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	8	9.597656e-03	6
GO:CC	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	2	1.283851e-02	6
GO:CC	GO:0000791	euchromatin	"A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156]	2	3.143302e-02	6
GO:CC	GO:0034693	U11/U12 snRNP	"A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins." [GOC:mah, PMID:15146077]	1	4.988814e-02	6

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5352	10q11 21q11 23 copy number variation syndrome	10q11 21q11 23 copy number variation syndrome	3	0.001246	6

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	3	0.001563	6
GO:MF	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	3	0.001642	6
GO:MF	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	3	0.003457	6
GO:MF	GO:0120545	nucleic acid conformation isomerase activity	"Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-]	3	0.004148	6
GO:MF	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	2	0.004602	6
GO:MF	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	6	0.011627	6
GO:MF	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	3	0.012080	6
GO:MF	GO:0140097	catalytic activity, acting on DNA	"Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt]	3	0.014944	6
GO:MF	GO:0120543	macromolecular conformation isomerase activity	"Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-]	3	0.020646	6
GO:MF	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	2	0.030902	6

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:6194	B-WICH complex	B-WICH complex	2	0.002053	6
CORUM	CORUM:6302	B-WICH complex	B-WICH complex	2	0.002637	6
CORUM	CORUM:929	CEN complex	CEN complex	2	0.040288	6
CORUM	CORUM:2791	MCM4-MCM6-MCM7 complex	MCM4-MCM6-MCM7 complex	1	0.049819	6

biogrid+hippie (Louvain)

View:

Community 0

GO:CC

source	term_id	annotation	description	intersection_size	p_value
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	209	8.191896e-32
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	140	7.818887e-30
GO:CC	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	92	4.303493e-28
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	79	9.056693e-20
GO:CC	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917]	79	2.549343e-19
GO:CC	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	59	2.636160e-18
GO:CC	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	42	3.891242e-17
GO:CC	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	45	8.888536e-17
GO:CC	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	71	1.621943e-15
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	44	1.650857e-15
GO:CC	GO:0099080	supramolecular complex	"A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]	53	5.772192e-14
GO:CC	GO:0099512	supramolecular fiber	"A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos]	42	1.307138e-11
GO:CC	GO:0099081	supramolecular polymer	"A polymeric supramolecular structure." [GOC:dos]	42	1.681674e-11
GO:CC	GO:0030877	beta-catenin destruction complex	"A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]	8	1.826523e-11
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	27	2.452985e-11
GO:CC	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	29	7.621113e-11
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	26	1.031510e-10
GO:CC	GO:0099513	polymeric cytoskeletal fiber	"A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos]	35	2.503903e-10
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	51	2.688979e-10
GO:CC	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	31	4.652786e-10
GO:CC	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	26	2.713230e-09
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	116	4.711002e-09
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	116	4.761282e-09
GO:CC	GO:0031252	cell leading edge	"The area of a motile cell closest to the direction of movement." [GOC:pg]	24	6.836696e-09
GO:CC	GO:0005912	adherens junction	"A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]	16	4.018424e-08
GO:CC	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	30	1.480819e-07
GO:CC	GO:0098978	glutamatergic synapse	"A synapse that uses glutamate as a neurotransmitter." [GOC:dos]	26	2.208114e-07
GO:CC	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	24	3.591467e-07
GO:CC	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	19	4.630051e-07
GO:CC	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	14	4.647006e-07
GO:CC	GO:1990909	Wnt signalosome	"A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]	6	6.344801e-07
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	213	8.273474e-07
GO:CC	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	14	1.182699e-06
GO:CC	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060]	38	4.272944e-06
GO:CC	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	27	4.472195e-06
GO:CC	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	20	9.565531e-06
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	198	9.836066e-06
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	204	9.920814e-06
GO:CC	GO:0043296	apical junction complex	"A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556]	12	2.487752e-05
GO:CC	GO:0005875	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	12	3.296281e-05
GO:CC	GO:0034451	centriolar satellite	"A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812]	11	3.307429e-05
GO:CC	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	13	6.910170e-05
GO:CC	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	13	8.648878e-05
GO:CC	GO:0016342	catenin complex	"Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323]	6	2.336351e-04
GO:CC	GO:0036477	somatodendritic compartment	"The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL]	26	2.813167e-04
GO:CC	GO:0005915	zonula adherens	"A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208]	4	4.791408e-04
GO:CC	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	11	6.331823e-04
GO:CC	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	24	6.959959e-04
GO:CC	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	21	8.561036e-04
GO:CC	GO:0019897	extrinsic component of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]	9	8.958181e-04
GO:CC	GO:0097447	dendritic tree	"The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168]	21	8.993855e-04
GO:CC	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	11	9.325680e-04
GO:CC	GO:0099572	postsynaptic specialization	"A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028]	16	1.191463e-03
GO:CC	GO:0000779	condensed chromosome, centromeric region	"The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]	11	1.216382e-03
GO:CC	GO:0002102	podosome	"An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982]	6	1.310815e-03
GO:CC	GO:0099091	postsynaptic specialization, intracellular component	"A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos]	5	1.434035e-03
GO:CC	GO:0016327	apicolateral plasma membrane	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]	5	1.434035e-03
GO:CC	GO:0098984	neuron to neuron synapse	"A synapse in which pre and post-synaptic cells are neurons." [GOC:dos]	16	1.913265e-03
GO:CC	GO:0098590	plasma membrane region	"A membrane that is a (regional) part of the plasma membrane." [GOC:dos]	32	1.995555e-03
GO:CC	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	95	3.268213e-03
GO:CC	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	89	4.583601e-03
GO:CC	GO:0000775	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]	12	6.508494e-03
GO:CC	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density]	14	7.148642e-03
GO:CC	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	10	7.862772e-03
GO:CC	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	10	9.889253e-03
GO:CC	GO:0097517	contractile actin filament bundle	"An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194]	7	1.055776e-02
GO:CC	GO:0001725	stress fiber	"A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381]	7	1.055776e-02
GO:CC	GO:1990752	microtubule end	"Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end." [GOC:pr]	5	1.151739e-02
GO:CC	GO:0032279	asymmetric synapse	"A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef]	14	1.158036e-02
GO:CC	GO:0016328	lateral plasma membrane	"The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr]	7	1.226162e-02
GO:CC	GO:0030056	hemidesmosome	"A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195]	3	1.340905e-02
GO:CC	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	24	1.414327e-02
GO:CC	GO:0099092	postsynaptic density, intracellular component	"A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos]	4	1.687364e-02
GO:CC	GO:0042641	actomyosin	"Any complex of actin, myosin, and accessory proteins." [GOC:go_curators]	7	1.753012e-02
GO:CC	GO:1904115	axon cytoplasm	"Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152]	6	1.799389e-02
GO:CC	GO:0032432	actin filament bundle	"An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah]	7	2.009971e-02
GO:CC	GO:0030018	Z disc	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]	8	2.389979e-02
GO:CC	GO:0000242	pericentriolar material	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]	4	2.507274e-02
GO:CC	GO:0036464	cytoplasmic ribonucleoprotein granule	"A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]	11	2.700331e-02
GO:CC	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	7	2.971805e-02
GO:CC	GO:0005916	fascia adherens	"A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:aruk, GOC:bc, GOC:mtg_muscle, PMID:11732910]	3	3.170065e-02
GO:CC	GO:0016600	flotillin complex	"A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709]	3	3.170065e-02
GO:CC	GO:0099568	cytoplasmic region	"Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos]	12	3.514803e-02
GO:CC	GO:0098685	Schaffer collateral - CA1 synapse	"A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell." [PMID:16399689]	7	3.577414e-02
GO:CC	GO:0034750	Scrib-APC-beta-catenin complex	"A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation." [PMID:16611247]	2	3.921395e-02
GO:CC	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	5	4.279690e-02
GO:CC	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	129	4.470350e-02
GO:CC	GO:0120103	centriolar subdistal appendage	"A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68." [GOC:cilia, PMID:23213374, PMID:27818179, PMID:28422092]	3	4.494712e-02
GO:CC	GO:0044291	cell-cell contact zone	"Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018]	6	4.741907e-02
GO:CC	GO:0035371	microtubule plus-end	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]	4	4.963485e-02

GO:BP

source	term_id	annotation	description	intersection_size	p_value
GO:BP	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	76	6.769872e-28
GO:BP	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	52	1.822700e-18
GO:BP	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	43	4.074191e-18
GO:BP	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	98	3.044622e-17
GO:BP	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	35	1.297401e-16
GO:BP	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	57	1.303725e-16
GO:BP	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	77	6.529298e-16
GO:BP	GO:0023057	negative regulation of signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	58	1.058507e-15
GO:BP	GO:0010648	negative regulation of cell communication	"Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	58	1.093813e-15
GO:BP	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	28	1.219125e-14
GO:BP	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	91	2.706521e-14
GO:BP	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	90	1.087626e-13
GO:BP	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	83	1.157821e-13
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	92	2.284134e-13
GO:BP	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	190	2.472861e-13
GO:BP	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	59	3.530473e-13
GO:BP	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	193	4.635061e-13
GO:BP	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	186	5.262139e-13
GO:BP	GO:0030030	cell projection organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917]	57	1.648304e-12
GO:BP	GO:0032886	regulation of microtubule-based process	"Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah]	24	3.080323e-12
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	76	3.924393e-12
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	76	4.969278e-12
GO:BP	GO:0030111	regulation of Wnt signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]	26	5.455374e-12
GO:BP	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	127	8.343305e-12
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc]	55	8.893521e-12
GO:BP	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	126	1.747100e-11
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	"Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb]	22	1.245426e-10
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	80	1.513864e-10
GO:BP	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	21	2.190671e-10
GO:BP	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	117	2.875021e-10
GO:BP	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	71	5.321874e-10
GO:BP	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	116	7.360125e-10
GO:BP	GO:0051493	regulation of cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]	29	7.427111e-10
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	18	9.687925e-10
GO:BP	GO:0031023	microtubule organizing center organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah]	17	1.646162e-09
GO:BP	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	131	3.150153e-09
GO:BP	GO:1902531	regulation of intracellular signal transduction	"Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	57	3.513064e-09
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	16	4.078523e-09
GO:BP	GO:0048583	regulation of response to stimulus	"Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	88	4.078568e-09
GO:BP	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	73	4.461294e-09
GO:BP	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	17	5.149044e-09
GO:BP	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	67	7.275986e-09
GO:BP	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	39	7.360746e-09
GO:BP	GO:0034453	microtubule anchoring	"Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]	9	9.067638e-09
GO:BP	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	10	9.494233e-09
GO:BP	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	88	9.525882e-09
GO:BP	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	120	1.081678e-08
GO:BP	GO:1905508	protein localization to microtubule organizing center	"A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497]	10	1.276476e-08
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	54	1.771635e-08
GO:BP	GO:0000902	cell morphogenesis	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]	38	1.900220e-08
GO:BP	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	36	2.368435e-08
GO:BP	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	138	2.407056e-08
GO:BP	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	96	2.836044e-08
GO:BP	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	44	3.068153e-08
GO:BP	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	69	3.092938e-08
GO:BP	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	38	4.184963e-08
GO:BP	GO:0034330	cell junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]	34	4.628582e-08
GO:BP	GO:0072698	protein localization to microtubule cytoskeleton	"A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah]	11	5.278632e-08
GO:BP	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	46	5.301562e-08
GO:BP	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	106	5.364460e-08
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	30	6.120407e-08
GO:BP	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	69	7.728079e-08
GO:BP	GO:0033043	regulation of organelle organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]	40	8.066041e-08
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	"The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc]	30	1.021210e-07
GO:BP	GO:0048699	generation of neurons	"The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]	47	1.032701e-07
GO:BP	GO:0097435	supramolecular fiber organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr]	34	1.089998e-07
GO:BP	GO:0044380	protein localization to cytoskeleton	"A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl]	11	1.134801e-07
GO:BP	GO:0048858	cell projection morphogenesis	"The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021]	30	1.222041e-07
GO:BP	GO:0043085	positive regulation of catalytic activity	"Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	27	1.284527e-07
GO:BP	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	55	1.685125e-07
GO:BP	GO:0048666	neuron development	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]	40	1.710128e-07
GO:BP	GO:0071840	cellular component organization or biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]	138	1.942234e-07
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	37	2.719517e-07
GO:BP	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	29	2.792939e-07
GO:BP	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	105	3.078334e-07
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	54	3.671147e-07
GO:BP	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	50	3.769462e-07
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	43	4.724236e-07
GO:BP	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	36	4.891271e-07
GO:BP	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	40	5.889916e-07
GO:BP	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	14	7.532148e-07
GO:BP	GO:0044093	positive regulation of molecular function	"Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]	33	9.179975e-07
GO:BP	GO:0034329	cell junction assembly	"A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah]	24	2.436683e-06
GO:BP	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	105	2.770931e-06
GO:BP	GO:0030010	establishment of cell polarity	"The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	14	4.060238e-06
GO:BP	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	141	4.223281e-06
GO:BP	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	43	5.462552e-06
GO:BP	GO:0019220	regulation of phosphate metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	33	6.539424e-06
GO:BP	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	105	6.653915e-06
GO:BP	GO:0051174	regulation of phosphorus metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]	33	6.710483e-06
GO:BP	GO:0072393	microtubule anchoring at microtubule organizing center	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938]	6	8.401950e-06
GO:BP	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	43	1.068319e-05
GO:BP	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	121	1.139447e-05
GO:BP	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	65	1.171701e-05
GO:BP	GO:0009896	positive regulation of catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	24	1.217578e-05
GO:BP	GO:0007044	cell-substrate junction assembly	"The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah]	11	1.430032e-05
GO:BP	GO:0070925	organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	34	1.662124e-05
GO:BP	GO:0031399	regulation of protein modification process	"Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	34	1.784689e-05
GO:BP	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	85	1.810986e-05
GO:BP	GO:0048869	cellular developmental process	"A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]	85	1.831044e-05
GO:BP	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	63	1.928449e-05
GO:BP	GO:0150115	cell-substrate junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	11	3.028292e-05
GO:BP	GO:0099111	microtubule-based transport	"A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	15	3.550424e-05
GO:BP	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	107	3.766623e-05
GO:BP	GO:0141124	intracellular signaling cassette	"An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg]	48	4.283323e-05
GO:BP	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	31	4.409706e-05
GO:BP	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	46	4.715902e-05
GO:BP	GO:0042325	regulation of phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]	29	5.009785e-05
GO:BP	GO:0031109	microtubule polymerization or depolymerization	"Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]	12	6.846495e-05
GO:BP	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	65	7.107961e-05
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	"The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb]	24	7.150944e-05
GO:BP	GO:1902903	regulation of supramolecular fiber organization	"Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]	19	7.704169e-05
GO:BP	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	55	8.007831e-05
GO:BP	GO:0006793	phosphorus metabolic process	"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]	55	8.355354e-05
GO:BP	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	9	9.670255e-05
GO:BP	GO:0031344	regulation of cell projection organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]	25	1.020857e-04
GO:BP	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	41	1.053852e-04
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	39	1.096299e-04
GO:BP	GO:0010970	transport along microtubule	"The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb]	13	1.459566e-04
GO:BP	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	32	1.675646e-04
GO:BP	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	24	1.729580e-04
GO:BP	GO:0033365	protein localization to organelle	"A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]	35	1.750808e-04
GO:BP	GO:0001932	regulation of protein phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]	27	1.870858e-04
GO:BP	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	26	1.891747e-04
GO:BP	GO:0043412	macromolecule modification	"The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]	63	2.068057e-04
GO:BP	GO:0031110	regulation of microtubule polymerization or depolymerization	"Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]	10	2.155913e-04
GO:BP	GO:0019941	modification-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]	24	2.315939e-04
GO:BP	GO:0043632	modification-dependent macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl]	24	2.673718e-04
GO:BP	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	48	2.778036e-04
GO:BP	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	35	3.102321e-04
GO:BP	GO:0007507	heart development	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]	23	3.592939e-04
GO:BP	GO:0071896	protein localization to adherens junction	"Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237]	4	3.994138e-04
GO:BP	GO:0048729	tissue morphogenesis	"The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid]	23	4.664139e-04
GO:BP	GO:0140694	membraneless organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081]	19	4.682684e-04
GO:BP	GO:0030029	actin filament-based process	"Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]	27	5.863709e-04
GO:BP	GO:1903050	regulation of proteolysis involved in protein catabolic process	"Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]	14	6.007568e-04
GO:BP	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	14	6.324657e-04
GO:BP	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	13	6.362072e-04
GO:BP	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	32	6.685638e-04
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	"Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]	27	6.760814e-04
GO:BP	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	12	6.800960e-04
GO:BP	GO:0048041	focal adhesion assembly	"The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah]	9	6.897905e-04
GO:BP	GO:0031346	positive regulation of cell projection organization	"Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]	17	7.347277e-04
GO:BP	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	26	8.096599e-04
GO:BP	GO:0051656	establishment of organelle localization	"The directed movement of an organelle to a specific location." [GOC:ai]	20	8.128851e-04
GO:BP	GO:0030705	cytoskeleton-dependent intracellular transport	"The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]	13	9.399357e-04
GO:BP	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	92	9.594476e-04
GO:BP	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	33	9.783891e-04
GO:BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	18	1.246196e-03
GO:BP	GO:0045216	cell-cell junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	13	1.297231e-03
GO:BP	GO:0007409	axonogenesis	"De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]	19	1.437402e-03
GO:BP	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	83	1.485616e-03
GO:BP	GO:0045862	positive regulation of proteolysis	"Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]	13	1.517799e-03
GO:BP	GO:0009056	catabolic process	"A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	55	1.662140e-03
GO:BP	GO:0001952	regulation of cell-matrix adhesion	"Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]	10	1.695131e-03
GO:BP	GO:0051640	organelle localization	"Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]	22	2.142313e-03
GO:BP	GO:0007043	cell-cell junction assembly	"The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]	11	2.146563e-03
GO:BP	GO:1901888	regulation of cell junction assembly	"Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	14	2.209673e-03
GO:BP	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	52	2.299364e-03
GO:BP	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	19	2.312796e-03
GO:BP	GO:0007049	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]	40	2.435779e-03
GO:BP	GO:0061564	axon development	"The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr]	20	2.517830e-03
GO:BP	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	7	2.790945e-03
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	82	3.092098e-03
GO:BP	GO:0031589	cell-substrate adhesion	"The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf]	16	3.494712e-03
GO:BP	GO:0010975	regulation of neuron projection development	"Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	18	3.612424e-03
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc]	22	3.795917e-03
GO:BP	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	20	3.864338e-03
GO:BP	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	9	4.180893e-03
GO:BP	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	10	4.289852e-03
GO:BP	GO:0030162	regulation of proteolysis	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]	17	4.312393e-03
GO:BP	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	29	4.428076e-03
GO:BP	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]	10	4.587285e-03
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	"Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	21	4.736206e-03
GO:BP	GO:0002009	morphogenesis of an epithelium	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]	19	4.896320e-03
GO:BP	GO:0035088	establishment or maintenance of apical/basal cell polarity	"Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]	7	5.269861e-03
GO:BP	GO:0061245	establishment or maintenance of bipolar cell polarity	"Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns." [GOC:dph, GOC:vw]	7	5.269861e-03
GO:BP	GO:0034332	adherens junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah]	7	5.269861e-03
GO:BP	GO:0001837	epithelial to mesenchymal transition	"A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]	11	5.287702e-03
GO:BP	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	33	5.613568e-03
GO:BP	GO:1900181	negative regulation of protein localization to nucleus	"Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]	6	6.225735e-03
GO:BP	GO:0030031	cell projection assembly	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:18391171]	21	6.618531e-03
GO:BP	GO:0070884	regulation of calcineurin-NFAT signaling cascade	"Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:ai]	6	7.292002e-03
GO:BP	GO:0044085	cellular component biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]	84	7.298564e-03
GO:BP	GO:0106056	regulation of calcineurin-mediated signaling	"Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204]	6	8.502253e-03
GO:BP	GO:0051248	negative regulation of protein metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]	22	8.930767e-03
GO:BP	GO:0035148	tube formation	"Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf]	10	9.825178e-03
GO:BP	GO:0090109	regulation of cell-substrate junction assembly	"Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb]	7	1.044174e-02
GO:BP	GO:0051893	regulation of focal adhesion assembly	"Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai]	7	1.044174e-02
GO:BP	GO:0034454	microtubule anchoring at centrosome	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]	4	1.252740e-02
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	14	1.338503e-02
GO:BP	GO:0060322	head development	"The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph]	24	1.419110e-02
GO:BP	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	23	1.512071e-02
GO:BP	GO:0030901	midbrain development	"The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [PMID:4975589, PMID:4992177]	8	1.523651e-02
GO:BP	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	38	1.698896e-02
GO:BP	GO:0150116	regulation of cell-substrate junction organization	"Any process that modulates the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk]	7	1.748234e-02
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	42	1.750611e-02
GO:BP	GO:0010631	epithelial cell migration	"The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb]	8	1.785382e-02
GO:BP	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	65	1.814240e-02
GO:BP	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	62	1.895741e-02
GO:BP	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	10	1.961747e-02
GO:BP	GO:0033173	calcineurin-NFAT signaling cascade	"Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+)." [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679]	6	1.966203e-02
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	59	2.009316e-02
GO:BP	GO:0061136	regulation of proteasomal protein catabolic process	"Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb]	11	2.054902e-02
GO:BP	GO:0009719	response to endogenous stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]	35	2.073762e-02
GO:BP	GO:0048589	developmental growth	"The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]	21	2.196107e-02
GO:BP	GO:0090132	epithelium migration	"The process in which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]	8	2.248563e-02
GO:BP	GO:0046785	microtubule polymerization	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]	8	2.248563e-02
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]	19	2.272370e-02
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	19	2.272370e-02
GO:BP	GO:0005979	regulation of glycogen biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]	5	2.296969e-02
GO:BP	GO:0010962	regulation of glucan biosynthetic process	"Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb]	5	2.296969e-02
GO:BP	GO:0061572	actin filament bundle organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph]	10	2.309467e-02
GO:BP	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	9	2.429220e-02
GO:BP	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	19	2.448734e-02
GO:BP	GO:0071681	cellular response to indole-3-methanol	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf]	3	2.512776e-02
GO:BP	GO:0097720	calcineurin-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544]	6	2.530207e-02
GO:BP	GO:0045667	regulation of osteoblast differentiation	"Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]	9	2.584366e-02
GO:BP	GO:0051258	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	13	2.764077e-02
GO:BP	GO:0003281	ventricular septum development	"The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart]	7	2.807660e-02
GO:BP	GO:0031929	TOR signaling	"The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]	10	2.854917e-02
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	30	2.988612e-02
GO:BP	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	29	3.360658e-02
GO:BP	GO:0106057	negative regulation of calcineurin-mediated signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204]	4	3.367955e-02
GO:BP	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:mah]	4	3.367955e-02
GO:BP	GO:0150011	regulation of neuron projection arborization	"Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches." [GOC:aruk, GOC:bc, PMID:17114044]	4	3.367955e-02
GO:BP	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	25	3.376710e-02
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	60	3.445267e-02
GO:BP	GO:0006913	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	14	3.460490e-02
GO:BP	GO:0051169	nuclear transport	"The directed movement of substances into, out of, or within the nucleus." [GOC:ai]	14	3.460490e-02
GO:BP	GO:0090130	tissue migration	"The process in which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]	8	3.482958e-02
GO:BP	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	13	3.575509e-02
GO:BP	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	21	3.653698e-02
GO:BP	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	8	3.735730e-02
GO:BP	GO:0043297	apical junction assembly	"The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556]	7	3.995973e-02
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	"Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]	8	4.003736e-02
GO:BP	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	20	4.073830e-02
GO:BP	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	11	4.085505e-02
GO:BP	GO:0046328	regulation of JNK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]	9	4.404211e-02
GO:BP	GO:1903828	negative regulation of protein localization	"Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	11	4.653778e-02
GO:BP	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	20	4.865392e-02
GO:BP	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA	"Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544]	3	4.985610e-02
GO:BP	GO:0071680	response to indole-3-methanol	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf]	3	4.985610e-02

KEGG

source	term_id	annotation	description	intersection_size	p_value
KEGG	KEGG:04390	Hippo signaling pathway	Hippo signaling pathway	25	5.854465e-19
KEGG	KEGG:04310	Wnt signaling pathway	Wnt signaling pathway	19	5.350567e-11
KEGG	KEGG:05217	Basal cell carcinoma	Basal cell carcinoma	12	1.663784e-09
KEGG	KEGG:05226	Gastric cancer	Gastric cancer	15	5.184380e-08
KEGG	KEGG:05224	Breast cancer	Breast cancer	14	4.600250e-07
KEGG	KEGG:05165	Human papillomavirus infection	Human papillomavirus infection	20	5.659622e-07
KEGG	KEGG:05200	Pathways in cancer	Pathways in cancer	24	3.936414e-06
KEGG	KEGG:05225	Hepatocellular carcinoma	Hepatocellular carcinoma	13	1.740975e-05
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	Pathways of neurodegeneration - multiple diseases	21	5.030832e-05
KEGG	KEGG:05213	Endometrial cancer	Endometrial cancer	8	6.109626e-05
KEGG	KEGG:04520	Adherens junction	Adherens junction	9	2.552893e-04
KEGG	KEGG:04150	mTOR signaling pathway	mTOR signaling pathway	11	4.220383e-04
KEGG	KEGG:04114	Oocyte meiosis	Oocyte meiosis	10	6.112624e-04
KEGG	KEGG:05010	Alzheimer disease	Alzheimer disease	17	6.547132e-04
KEGG	KEGG:04550	Signaling pathways regulating pluripotency of stem cells	Signaling pathways regulating pluripotency of stem cells	10	1.329692e-03
KEGG	KEGG:04934	Cushing syndrome	Cushing syndrome	10	2.397535e-03
KEGG	KEGG:05100	Bacterial invasion of epithelial cells	Bacterial invasion of epithelial cells	7	5.118761e-03
KEGG	KEGG:05131	Shigellosis	Shigellosis	12	6.757615e-03
KEGG	KEGG:04670	Leukocyte transendothelial migration	Leukocyte transendothelial migration	8	9.624077e-03
KEGG	KEGG:05163	Human cytomegalovirus infection	Human cytomegalovirus infection	11	1.238233e-02
KEGG	KEGG:04152	AMPK signaling pathway	AMPK signaling pathway	8	1.378036e-02
KEGG	KEGG:04151	PI3K-Akt signaling pathway	PI3K-Akt signaling pathway	14	1.691062e-02
KEGG	KEGG:04140	Autophagy - animal	Autophagy - animal	9	2.446803e-02

GO:MF

source	term_id	annotation	description	intersection_size	p_value
GO:MF	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	52	6.063282e-18
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	219	1.682781e-13
GO:MF	GO:0008013	beta-catenin binding	"Binding to a catenin beta subunit." [GOC:bf]	17	2.424305e-12
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	63	1.718770e-10
GO:MF	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	35	2.984330e-09
GO:MF	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	32	1.789779e-08
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	21	1.268694e-07
GO:MF	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	27	1.467089e-07
GO:MF	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	18	1.767381e-06
GO:MF	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	20	1.134570e-05
GO:MF	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	26	1.512042e-05
GO:MF	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	21	1.709744e-05
GO:MF	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	36	5.339790e-05
GO:MF	GO:0048156	tau protein binding	"Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]	7	2.212744e-04
GO:MF	GO:0051018	protein kinase A binding	"Binding to a protein kinase A." [GOC:ai]	7	1.093215e-03
GO:MF	GO:0004721	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684]	14	1.648577e-03
GO:MF	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	25	1.649857e-03
GO:MF	GO:0017166	vinculin binding	"Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544]	4	3.223307e-03
GO:MF	GO:0045295	gamma-catenin binding	"Binding to catenin complex gamma subunit." [GOC:bf]	4	3.223307e-03
GO:MF	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate." [GOC:curators, GOC:pg]	16	4.506628e-03
GO:MF	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	4	4.614231e-03
GO:MF	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [GOC:mah]	4	4.614231e-03
GO:MF	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	28	4.670976e-03
GO:MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-]	26	6.463038e-03
GO:MF	GO:0030674	protein-macromolecule adaptor activity	"An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	28	8.574698e-03
GO:MF	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	56	1.008870e-02
GO:MF	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	33	1.012946e-02
GO:MF	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	226	1.749042e-02
GO:MF	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	9	1.878645e-02
GO:MF	GO:0042578	phosphoric ester hydrolase activity	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]	17	2.055238e-02
GO:MF	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	35	2.306180e-02
GO:MF	GO:0045309	protein phosphorylated amino acid binding	"Binding to a phosphorylated amino acid residue within a protein." [GOC:go_curators]	6	2.382077e-02
GO:MF	GO:0005109	frizzled binding	"Binding to a frizzled (fz) receptor." [GOC:ceb]	5	2.539104e-02
GO:MF	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	10	3.023417e-02
GO:MF	GO:0106310	protein serine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989]	14	3.039991e-02
GO:MF	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	8	3.207149e-02
GO:MF	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	12	3.404482e-02
GO:MF	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	4	3.594850e-02
GO:MF	GO:0051219	phosphoprotein binding	"Binding to a phosphorylated protein." [GOC:ai]	7	4.013324e-02
GO:MF	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	31	4.110620e-02

REAC

source	term_id	annotation	description	intersection_size	p_value
REAC	REAC:R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	Disassembly of the destruction complex and recruitment of AXIN to the membrane	13	3.567664e-14
REAC	REAC:R-HSA-162582	Signal Transduction	Signal Transduction	83	8.594308e-14
REAC	REAC:R-HSA-195721	Signaling by WNT	Signaling by WNT	25	1.618186e-09
REAC	REAC:R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	Regulation of PLK1 Activity at G2/M Transition	14	4.482192e-09
REAC	REAC:R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	36	4.768279e-09
REAC	REAC:R-HSA-196299	Beta-catenin phosphorylation cascade	Beta-catenin phosphorylation cascade	8	1.176159e-08
REAC	REAC:R-HSA-194315	Signaling by Rho GTPases	Signaling by Rho GTPases	34	5.337797e-08
REAC	REAC:R-HSA-8854518	AURKA Activation by TPX2	AURKA Activation by TPX2	12	1.036911e-07
REAC	REAC:R-HSA-201681	TCF dependent signaling in response to WNT	TCF dependent signaling in response to WNT	19	2.246348e-07
REAC	REAC:R-HSA-4791275	Signaling by WNT in cancer	Signaling by WNT in cancer	9	2.797438e-07
REAC	REAC:R-HSA-380259	Loss of Nlp from mitotic centrosomes	Loss of Nlp from mitotic centrosomes	11	9.713894e-07
REAC	REAC:R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	Loss of proteins required for interphase microtubule organization from the centrosome	11	9.713894e-07
REAC	REAC:R-HSA-380287	Centrosome maturation	Centrosome maturation	11	5.743382e-06
REAC	REAC:R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	Recruitment of mitotic centrosome proteins and complexes	11	5.743382e-06
REAC	REAC:R-HSA-69275	G2/M Transition	G2/M Transition	16	6.303122e-06
REAC	REAC:R-HSA-453274	Mitotic G2-G2/M phases	Mitotic G2-G2/M phases	16	7.285533e-06
REAC	REAC:R-HSA-4839743	Signaling by CTNNB1 phospho-site mutants	Signaling by CTNNB1 phospho-site mutants	6	1.331413e-05
REAC	REAC:R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	CTNNB1 T41 mutants aren't phosphorylated	6	1.331413e-05
REAC	REAC:R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	CTNNB1 S37 mutants aren't phosphorylated	6	1.331413e-05
REAC	REAC:R-HSA-5339716	Signaling by GSK3beta mutants	Signaling by GSK3beta mutants	6	1.331413e-05
REAC	REAC:R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	CTNNB1 S33 mutants aren't phosphorylated	6	1.331413e-05
REAC	REAC:R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	CTNNB1 S45 mutants aren't phosphorylated	6	1.331413e-05
REAC	REAC:R-HSA-111465	Apoptotic cleavage of cellular proteins	Apoptotic cleavage of cellular proteins	8	1.471174e-05
REAC	REAC:R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	Recruitment of NuMA to mitotic centrosomes	11	3.196023e-05
REAC	REAC:R-HSA-5620912	Anchoring of the basal body to the plasma membrane	Anchoring of the basal body to the plasma membrane	11	3.984932e-05
REAC	REAC:R-HSA-68877	Mitotic Prometaphase	Mitotic Prometaphase	15	5.606088e-05
REAC	REAC:R-HSA-109581	Apoptosis	Apoptosis	14	7.252492e-05
REAC	REAC:R-HSA-75153	Apoptotic execution phase	Apoptotic execution phase	8	2.053406e-04
REAC	REAC:R-HSA-180024	DARPP-32 events	DARPP-32 events	6	2.446282e-04
REAC	REAC:R-HSA-5467337	APC truncation mutants have impaired AXIN binding	APC truncation mutants have impaired AXIN binding	5	3.914079e-04
REAC	REAC:R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	AXIN missense mutants destabilize the destruction complex	5	3.914079e-04
REAC	REAC:R-HSA-4839735	Signaling by AXIN mutants	Signaling by AXIN mutants	5	3.914079e-04
REAC	REAC:R-HSA-4839748	Signaling by AMER1 mutants	Signaling by AMER1 mutants	5	3.914079e-04
REAC	REAC:R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	Truncations of AMER1 destabilize the destruction complex	5	3.914079e-04
REAC	REAC:R-HSA-4839744	Signaling by APC mutants	Signaling by APC mutants	5	3.914079e-04
REAC	REAC:R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	Diseases of signal transduction by growth factor receptors and second messengers	21	4.319203e-04
REAC	REAC:R-HSA-5357801	Programmed Cell Death	Programmed Cell Death	14	5.550976e-04
REAC	REAC:R-HSA-9696264	RND3 GTPase cycle	RND3 GTPase cycle	7	7.140196e-04
REAC	REAC:R-HSA-195253	Degradation of beta-catenin by the destruction complex	Degradation of beta-catenin by the destruction complex	9	9.739419e-04
REAC	REAC:R-HSA-5628897	TP53 Regulates Metabolic Genes	TP53 Regulates Metabolic Genes	9	1.077827e-03
REAC	REAC:R-HSA-114452	Activation of BH3-only proteins	Activation of BH3-only proteins	6	1.326320e-03
REAC	REAC:R-HSA-446728	Cell junction organization	Cell junction organization	10	1.859544e-03
REAC	REAC:R-HSA-3858494	Beta-catenin independent WNT signaling	Beta-catenin independent WNT signaling	11	2.212950e-03
REAC	REAC:R-HSA-199991	Membrane Trafficking	Membrane Trafficking	24	2.713126e-03
REAC	REAC:R-HSA-1500931	Cell-Cell communication	Cell-Cell communication	11	3.505971e-03
REAC	REAC:R-HSA-1640170	Cell Cycle	Cell Cycle	25	3.544436e-03
REAC	REAC:R-HSA-195258	RHO GTPase Effectors	RHO GTPase Effectors	16	4.253751e-03
REAC	REAC:R-HSA-9696273	RND1 GTPase cycle	RND1 GTPase cycle	6	1.019246e-02
REAC	REAC:R-HSA-9696270	RND2 GTPase cycle	RND2 GTPase cycle	6	1.170861e-02
REAC	REAC:R-HSA-9759475	Regulation of CDH11 Expression and Function	Regulation of CDH11 Expression and Function	5	1.361196e-02
REAC	REAC:R-HSA-111447	Activation of BAD and translocation to mitochondria	Activation of BAD and translocation to mitochondria	4	1.908508e-02
REAC	REAC:R-HSA-9764260	Regulation of Expression and Function of Type II Classical Cadherins	Regulation of Expression and Function of Type II Classical Cadherins	5	2.322292e-02
REAC	REAC:R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	Regulation of Homotypic Cell-Cell Adhesion	5	2.322292e-02
REAC	REAC:R-HSA-9012999	RHO GTPase cycle	RHO GTPase cycle	18	2.485745e-02
REAC	REAC:R-HSA-5653656	Vesicle-mediated transport	Vesicle-mediated transport	24	2.691894e-02
REAC	REAC:R-HSA-9833576	CDH11 homotypic and heterotypic interactions	CDH11 homotypic and heterotypic interactions	3	3.835206e-02
REAC	REAC:R-HSA-9764302	Regulation of CDH19 Expression and Function	Regulation of CDH19 Expression and Function	3	3.835206e-02
REAC	REAC:R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	COPI-independent Golgi-to-ER retrograde traffic	6	3.926474e-02
REAC	REAC:R-HSA-109606	Intrinsic Pathway for Apoptosis	Intrinsic Pathway for Apoptosis	6	4.366422e-02
REAC	REAC:R-HSA-418990	Adherens junctions interactions	Adherens junctions interactions	6	4.844665e-02

WP

source	term_id	annotation	description	intersection_size	p_value
WP	WP:WP363	Wnt signaling NetPath	Wnt signaling NetPath	11	1.346519e-08
WP	WP:WP5376	17p13 3 YWHAE copy number variation	17p13 3 YWHAE copy number variation	8	7.589032e-08
WP	WP:WP4258	lncRNA in canonical Wnt signaling and colorectal cancer	lncRNA in canonical Wnt signaling and colorectal cancer	13	3.718465e-07
WP	WP:WP3664	Regulation of Wnt B catenin signaling by small molecule compounds	Regulation of Wnt B catenin signaling by small molecule compounds	7	5.276284e-07
WP	WP:WP399	Wnt signaling and pluripotency	Wnt signaling and pluripotency	13	5.459567e-07
WP	WP:WP428	Wnt signaling	Wnt signaling	13	2.497051e-06
WP	WP:WP5087	Pleural mesothelioma	Pleural mesothelioma	24	5.194487e-06
WP	WP:WP5529	Wnt Beta catenin signaling and ARTD family members	Wnt Beta catenin signaling and ARTD family members	6	9.558657e-06
WP	WP:WP4262	Breast cancer pathway	Breast cancer pathway	14	1.404963e-05
WP	WP:WP4336	ncRNAs in Wnt signaling in hepatocellular carcinoma	ncRNAs in Wnt signaling in hepatocellular carcinoma	11	1.465366e-05
WP	WP:WP4560	MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement	MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement	6	3.415877e-05
WP	WP:WP5124	Alzheimer 39 s disease	Alzheimer 39 s disease	17	6.634969e-05
WP	WP:WP5434	Cancer pathways	Cancer pathways	24	8.563952e-05
WP	WP:WP2059	Alzheimer 39 s disease and miRNA effects	Alzheimer 39 s disease and miRNA effects	17	8.696830e-05
WP	WP:WP3680	Physico chemical features and toxicity associated pathways	Physico chemical features and toxicity associated pathways	9	1.117279e-04
WP	WP:WP4872	MAP3K1 role in promoting and blocking gonadal determination	MAP3K1 role in promoting and blocking gonadal determination	5	7.866508e-04
WP	WP:WP4155	Endometrial cancer	Endometrial cancer	8	8.487716e-04
WP	WP:WP2571	Polycystic kidney disease pathway	Polycystic kidney disease pathway	9	8.839512e-04
WP	WP:WP2380	Brain derived neurotrophic factor BDNF signaling	Brain derived neurotrophic factor BDNF signaling	11	1.295952e-03
WP	WP:WP4150	Wnt signaling in kidney disease	Wnt signaling in kidney disease	6	2.867989e-03
WP	WP:WP4141	PI3K AKT mTOR vitamin D3 signaling	PI3K AKT mTOR vitamin D3 signaling	5	3.150730e-03
WP	WP:WP2064	Neural crest differentiation	Neural crest differentiation	9	4.040593e-03
WP	WP:WP5353	Macrophage stimulating protein MSP signaling	Macrophage stimulating protein MSP signaling	9	6.924591e-03
WP	WP:WP710	DNA damage response only ATM dependent	DNA damage response only ATM dependent	9	7.452632e-03
WP	WP:WP3658	Wnt beta catenin signaling in leukemia	Wnt beta catenin signaling in leukemia	5	7.497977e-03
WP	WP:WP5426	HDAC6 interactions in the central nervous system	HDAC6 interactions in the central nervous system	9	9.245998e-03
WP	WP:WP3931	Embryonic stem cell pluripotency pathways	Embryonic stem cell pluripotency pathways	9	1.304362e-02
WP	WP:WP5502	16p13 11 copy number variation syndrome	16p13 11 copy number variation syndrome	5	1.305372e-02
WP	WP:WP2572	Primary focal segmental glomerulosclerosis FSGS	Primary focal segmental glomerulosclerosis FSGS	7	2.005868e-02
WP	WP:WP4216	Chromosomal and microsatellite instability in colorectal cancer	Chromosomal and microsatellite instability in colorectal cancer	7	2.191075e-02
WP	WP:WP5475	Hallmark of cancer sustaining proliferative signaling	Hallmark of cancer sustaining proliferative signaling	8	2.217425e-02
WP	WP:WP481	Insulin signaling	Insulin signaling	10	2.945528e-02
WP	WP:WP3888	VEGFA VEGFR2 signaling	VEGFA VEGFR2 signaling	17	4.871955e-02

MIRNA

source	term_id	annotation	description	intersection_size	p_value
MIRNA	MIRNA:hsa-mir-139-5p	hsa-mir-139-5p	hsa-mir-139-5p	41	2.433313e-07
MIRNA	MIRNA:hsa-mir-200a	hsa-mir-200a	hsa-mir-200a	51	6.525982e-07
MIRNA	MIRNA:hsa-mir-141	hsa-mir-141	hsa-mir-141	51	6.525982e-07
MIRNA	MIRNA:hsa-mir-548ah	hsa-mir-548ah	hsa-mir-548ah	50	2.745631e-06
MIRNA	MIRNA:hsa-mir-4666-3p	hsa-mir-4666-3p	hsa-mir-4666-3p	49	6.151676e-06
MIRNA	MIRNA:hsa-mir-582-5p	hsa-mir-582-5p	hsa-mir-582-5p	47	8.421746e-06
MIRNA	MIRNA:hsa-mir-3609	hsa-mir-3609	hsa-mir-3609	51	9.004131e-06
MIRNA	MIRNA:hsa-mir-548z	hsa-mir-548z	hsa-mir-548z	55	2.189535e-05
MIRNA	MIRNA:hsa-mir-548ac	hsa-mir-548ac	hsa-mir-548ac	55	2.189535e-05
MIRNA	MIRNA:hsa-mir-548d-3p	hsa-mir-548d-3p	hsa-mir-548d-3p	55	2.401185e-05
MIRNA	MIRNA:hsa-mir-330-3p	hsa-mir-330-3p	hsa-mir-330-3p	48	3.391963e-05
MIRNA	MIRNA:hsa-mir-15a	hsa-mir-15a	hsa-mir-15a	57	5.277477e-05
MIRNA	MIRNA:hsa-mir-497	hsa-mir-497	hsa-mir-497	57	5.277477e-05
MIRNA	MIRNA:hsa-mir-15b	hsa-mir-15b	hsa-mir-15b	57	5.277477e-05
MIRNA	MIRNA:hsa-mir-424	hsa-mir-424	hsa-mir-424	57	5.277477e-05
MIRNA	MIRNA:hsa-mir-195	hsa-mir-195	hsa-mir-195	57	5.277477e-05
MIRNA	MIRNA:hsa-mir-16	hsa-mir-16	hsa-mir-16	57	5.277477e-05
MIRNA	MIRNA:hsa-mir-92a-3p	hsa-mir-92a-3p	hsa-mir-92a-3p	42	8.909784e-05
MIRNA	MIRNA:hsa-mir-4698	hsa-mir-4698	hsa-mir-4698	56	1.205410e-04
MIRNA	MIRNA:hsa-mir-3942-3p	hsa-mir-3942-3p	hsa-mir-3942-3p	46	1.454414e-04
MIRNA	MIRNA:hsa-mir-524-5p	hsa-mir-524-5p	hsa-mir-524-5p	57	2.744215e-04
MIRNA	MIRNA:hsa-mir-520d-5p	hsa-mir-520d-5p	hsa-mir-520d-5p	57	2.787858e-04
MIRNA	MIRNA:hsa-mir-664	hsa-mir-664	hsa-mir-664	41	3.385110e-04
MIRNA	MIRNA:hsa-mir-548am	hsa-mir-548am	hsa-mir-548am	51	3.393057e-04
MIRNA	MIRNA:hsa-mir-548x	hsa-mir-548x	hsa-mir-548x	51	3.393057e-04
MIRNA	MIRNA:hsa-mir-548ae	hsa-mir-548ae	hsa-mir-548ae	51	3.393057e-04
MIRNA	MIRNA:hsa-mir-548aj	hsa-mir-548aj	hsa-mir-548aj	51	3.393057e-04
MIRNA	MIRNA:hsa-mir-3065-5p	hsa-mir-3065-5p	hsa-mir-3065-5p	45	4.510700e-04
MIRNA	MIRNA:hsa-mir-3163	hsa-mir-3163	hsa-mir-3163	64	4.647546e-04
MIRNA	MIRNA:hsa-mir-4753-3p	hsa-mir-4753-3p	hsa-mir-4753-3p	49	4.761807e-04
MIRNA	MIRNA:hsa-mir-3613-3p	hsa-mir-3613-3p	hsa-mir-3613-3p	70	5.004690e-04
MIRNA	MIRNA:hsa-mir-300	hsa-mir-300	hsa-mir-300	43	5.421923e-04
MIRNA	MIRNA:hsa-mir-144	hsa-mir-144	hsa-mir-144	44	5.858550e-04
MIRNA	MIRNA:hsa-mir-381	hsa-mir-381	hsa-mir-381	42	6.252924e-04
MIRNA	MIRNA:hsa-mir-107	hsa-mir-107	hsa-mir-107	47	6.507377e-04
MIRNA	MIRNA:hsa-mir-3160-5p	hsa-mir-3160-5p	hsa-mir-3160-5p	36	7.345343e-04
MIRNA	MIRNA:hsa-mir-1290	hsa-mir-1290	hsa-mir-1290	35	7.785334e-04
MIRNA	MIRNA:hsa-mir-615-3p	hsa-mir-615-3p	hsa-mir-615-3p	32	1.059471e-03
MIRNA	MIRNA:hsa-mir-362-5p	hsa-mir-362-5p	hsa-mir-362-5p	26	1.285044e-03
MIRNA	MIRNA:hsa-mir-103a	hsa-mir-103a	hsa-mir-103a	44	1.341396e-03
MIRNA	MIRNA:hsa-mir-500b	hsa-mir-500b	hsa-mir-500b	25	1.379558e-03
MIRNA	MIRNA:hsa-mir-4311	hsa-mir-4311	hsa-mir-4311	43	1.459739e-03
MIRNA	MIRNA:hsa-mir-3614-5p	hsa-mir-3614-5p	hsa-mir-3614-5p	42	1.610541e-03
MIRNA	MIRNA:hsa-mir-3942-5p	hsa-mir-3942-5p	hsa-mir-3942-5p	32	1.677344e-03
MIRNA	MIRNA:hsa-mir-4703-5p	hsa-mir-4703-5p	hsa-mir-4703-5p	32	1.754734e-03
MIRNA	MIRNA:hsa-mir-410	hsa-mir-410	hsa-mir-410	36	1.918933e-03
MIRNA	MIRNA:hsa-mir-4668-5p	hsa-mir-4668-5p	hsa-mir-4668-5p	52	1.938718e-03
MIRNA	MIRNA:hsa-mir-203	hsa-mir-203	hsa-mir-203	43	2.422595e-03
MIRNA	MIRNA:hsa-mir-93-5p	hsa-mir-93-5p	hsa-mir-93-5p	36	2.488822e-03
MIRNA	MIRNA:hsa-mir-548c-3p	hsa-mir-548c-3p	hsa-mir-548c-3p	73	2.606937e-03
MIRNA	MIRNA:hsa-mir-4276	hsa-mir-4276	hsa-mir-4276	37	2.713936e-03
MIRNA	MIRNA:hsa-mir-4796-3p	hsa-mir-4796-3p	hsa-mir-4796-3p	41	2.771960e-03
MIRNA	MIRNA:hsa-mir-503	hsa-mir-503	hsa-mir-503	29	3.284599e-03
MIRNA	MIRNA:hsa-mir-7	hsa-mir-7	hsa-mir-7	37	3.412561e-03
MIRNA	MIRNA:hsa-mir-548aa	hsa-mir-548aa	hsa-mir-548aa	46	3.667502e-03
MIRNA	MIRNA:hsa-mir-548ag	hsa-mir-548ag	hsa-mir-548ag	29	3.691110e-03
MIRNA	MIRNA:hsa-mir-548ai	hsa-mir-548ai	hsa-mir-548ai	29	3.691110e-03
MIRNA	MIRNA:hsa-mir-4328	hsa-mir-4328	hsa-mir-4328	48	4.398580e-03
MIRNA	MIRNA:hsa-mir-101	hsa-mir-101	hsa-mir-101	39	4.460274e-03
MIRNA	MIRNA:hsa-mir-4445	hsa-mir-4445	hsa-mir-4445	22	4.539623e-03
MIRNA	MIRNA:hsa-mir-374b	hsa-mir-374b	hsa-mir-374b	36	5.688132e-03
MIRNA	MIRNA:hsa-mir-374a	hsa-mir-374a	hsa-mir-374a	36	5.688132e-03
MIRNA	MIRNA:hsa-mir-4756-3p	hsa-mir-4756-3p	hsa-mir-4756-3p	39	5.809132e-03
MIRNA	MIRNA:hsa-mir-610	hsa-mir-610	hsa-mir-610	23	6.010281e-03
MIRNA	MIRNA:hsa-mir-3714	hsa-mir-3714	hsa-mir-3714	47	6.869718e-03
MIRNA	MIRNA:hsa-mir-527	hsa-mir-527	hsa-mir-527	40	6.909550e-03
MIRNA	MIRNA:hsa-mir-545	hsa-mir-545	hsa-mir-545	45	7.054798e-03
MIRNA	MIRNA:hsa-mir-518a-5p	hsa-mir-518a-5p	hsa-mir-518a-5p	40	7.146508e-03
MIRNA	MIRNA:hsa-mir-577	hsa-mir-577	hsa-mir-577	33	7.472684e-03
MIRNA	MIRNA:hsa-mir-19b	hsa-mir-19b	hsa-mir-19b	36	7.639367e-03
MIRNA	MIRNA:hsa-mir-19a	hsa-mir-19a	hsa-mir-19a	36	7.639367e-03
MIRNA	MIRNA:hsa-mir-3919	hsa-mir-3919	hsa-mir-3919	46	8.052771e-03
MIRNA	MIRNA:hsa-mir-142-5p	hsa-mir-142-5p	hsa-mir-142-5p	39	8.059599e-03
MIRNA	MIRNA:hsa-mir-4677-5p	hsa-mir-4677-5p	hsa-mir-4677-5p	33	8.080824e-03
MIRNA	MIRNA:hsa-mir-340	hsa-mir-340	hsa-mir-340	43	8.450670e-03
MIRNA	MIRNA:hsa-mir-92b	hsa-mir-92b	hsa-mir-92b	37	9.303094e-03
MIRNA	MIRNA:hsa-mir-367	hsa-mir-367	hsa-mir-367	37	9.303094e-03
MIRNA	MIRNA:hsa-mir-363	hsa-mir-363	hsa-mir-363	37	9.303094e-03
MIRNA	MIRNA:hsa-mir-25	hsa-mir-25	hsa-mir-25	37	9.303094e-03
MIRNA	MIRNA:hsa-mir-32	hsa-mir-32	hsa-mir-32	37	9.303094e-03
MIRNA	MIRNA:hsa-mir-92a	hsa-mir-92a	hsa-mir-92a	37	9.303094e-03
MIRNA	MIRNA:hsa-mir-3692	hsa-mir-3692	hsa-mir-3692	37	1.015370e-02
MIRNA	MIRNA:hsa-mir-3148	hsa-mir-3148	hsa-mir-3148	54	1.030957e-02
MIRNA	MIRNA:hsa-mir-488	hsa-mir-488	hsa-mir-488	34	1.040718e-02
MIRNA	MIRNA:hsa-mir-4307	hsa-mir-4307	hsa-mir-4307	42	1.095511e-02
MIRNA	MIRNA:hsa-mir-513a-5p	hsa-mir-513a-5p	hsa-mir-513a-5p	48	1.157422e-02
MIRNA	MIRNA:hsa-mir-299-5p	hsa-mir-299-5p	hsa-mir-299-5p	24	1.169692e-02
MIRNA	MIRNA:hsa-mir-3973	hsa-mir-3973	hsa-mir-3973	39	1.245574e-02
MIRNA	MIRNA:hsa-mir-579	hsa-mir-579	hsa-mir-579	49	1.316615e-02
MIRNA	MIRNA:hsa-mir-548b-3p	hsa-mir-548b-3p	hsa-mir-548b-3p	27	1.501635e-02
MIRNA	MIRNA:hsa-mir-3124-3p	hsa-mir-3124-3p	hsa-mir-3124-3p	41	1.582066e-02
MIRNA	MIRNA:hsa-mir-3685	hsa-mir-3685	hsa-mir-3685	31	1.744258e-02
MIRNA	MIRNA:hsa-mir-4427	hsa-mir-4427	hsa-mir-4427	32	1.790204e-02
MIRNA	MIRNA:hsa-mir-2276	hsa-mir-2276	hsa-mir-2276	33	1.818546e-02
MIRNA	MIRNA:hsa-mir-4282	hsa-mir-4282	hsa-mir-4282	54	1.863857e-02
MIRNA	MIRNA:hsa-mir-1324	hsa-mir-1324	hsa-mir-1324	39	1.867757e-02
MIRNA	MIRNA:hsa-mir-4511	hsa-mir-4511	hsa-mir-4511	31	1.883617e-02
MIRNA	MIRNA:hsa-mir-9	hsa-mir-9	hsa-mir-9	31	2.364971e-02
MIRNA	MIRNA:hsa-mir-3646	hsa-mir-3646	hsa-mir-3646	48	2.783999e-02
MIRNA	MIRNA:hsa-mir-1910	hsa-mir-1910	hsa-mir-1910	29	3.025945e-02
MIRNA	MIRNA:hsa-mir-106b-5p	hsa-mir-106b-5p	hsa-mir-106b-5p	31	3.181314e-02
MIRNA	MIRNA:hsa-mir-877-3p	hsa-mir-877-3p	hsa-mir-877-3p	21	3.296702e-02
MIRNA	MIRNA:hsa-mir-4801	hsa-mir-4801	hsa-mir-4801	39	3.374907e-02
MIRNA	MIRNA:hsa-mir-4731-3p	hsa-mir-4731-3p	hsa-mir-4731-3p	39	3.426552e-02
MIRNA	MIRNA:hsa-mir-3158-5p	hsa-mir-3158-5p	hsa-mir-3158-5p	39	3.426552e-02
MIRNA	MIRNA:hsa-mir-543	hsa-mir-543	hsa-mir-543	41	3.464798e-02
MIRNA	MIRNA:hsa-mir-326	hsa-mir-326	hsa-mir-326	37	3.466767e-02
MIRNA	MIRNA:hsa-mir-4680-3p	hsa-mir-4680-3p	hsa-mir-4680-3p	33	3.691082e-02
MIRNA	MIRNA:hsa-mir-1285	hsa-mir-1285	hsa-mir-1285	45	3.774249e-02
MIRNA	MIRNA:hsa-mir-570	hsa-mir-570	hsa-mir-570	47	4.056476e-02
MIRNA	MIRNA:hsa-mir-3119	hsa-mir-3119	hsa-mir-3119	33	4.089513e-02
MIRNA	MIRNA:hsa-mir-4527	hsa-mir-4527	hsa-mir-4527	22	4.160683e-02
MIRNA	MIRNA:hsa-mir-3064-5p	hsa-mir-3064-5p	hsa-mir-3064-5p	35	4.161354e-02
MIRNA	MIRNA:hsa-mir-513c	hsa-mir-513c	hsa-mir-513c	32	4.255878e-02
MIRNA	MIRNA:hsa-mir-646	hsa-mir-646	hsa-mir-646	41	4.367312e-02
MIRNA	MIRNA:hsa-mir-4672	hsa-mir-4672	hsa-mir-4672	40	4.536292e-02
MIRNA	MIRNA:hsa-mir-4719	hsa-mir-4719	hsa-mir-4719	45	4.556635e-02
MIRNA	MIRNA:hsa-mir-548m	hsa-mir-548m	hsa-mir-548m	29	4.600775e-02
MIRNA	MIRNA:hsa-mir-371-5p	hsa-mir-371-5p	hsa-mir-371-5p	45	4.617855e-02
MIRNA	MIRNA:hsa-mir-324-3p	hsa-mir-324-3p	hsa-mir-324-3p	40	4.948388e-02
MIRNA	MIRNA:hsa-mir-4652-3p	hsa-mir-4652-3p	hsa-mir-4652-3p	41	4.965027e-02

TF

source	term_id	annotation	description	intersection_size	p_value
TF	TF:M02036	Factor: WT1; motif: CGCCCCCNCN	Factor: WT1; motif: CGCCCCCNCN	165	2.761318e-07
TF	TF:M07208	Factor: EGR1; motif: NCNCCGCCCCCGCN	Factor: EGR1; motif: NCNCCGCCCCCGCN	121	4.403321e-07
TF	TF:M01873	Factor: Egr-1; motif: GCGGGGGCGG	Factor: Egr-1; motif: GCGGGGGCGG	127	9.277561e-07
TF	TF:M01219	Factor: SP1:SP3; motif: CCSCCCCCYCC	Factor: SP1:SP3; motif: CCSCCCCCYCC	128	9.767577e-07
TF	TF:M10108	Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG	Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG	123	3.390038e-06
TF	TF:M00695_1	Factor: ETF; motif: GVGGMGG; match class: 1	Factor: ETF; motif: GVGGMGG; match class: 1	129	4.021187e-06
TF	TF:M12722_1	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1	124	4.720955e-06
TF	TF:M03893	Factor: WT1; motif: GNGGGGGCGGGG	Factor: WT1; motif: GNGGGGGCGGGG	144	7.198283e-06
TF	TF:M01219_1	Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1	Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1	71	7.805298e-06
TF	TF:M12703_1	Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1	Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1	91	2.142704e-05
TF	TF:M09636_1	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1	204	4.090397e-05
TF	TF:M02089	Factor: E2F-3; motif: GGCGGGN	Factor: E2F-3; motif: GGCGGGN	195	5.412460e-05
TF	TF:M11529_1	Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1	Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1	207	7.416735e-05
TF	TF:M13144_1	Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS; match class: 1	Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS; match class: 1	103	8.731663e-05
TF	TF:M10026	Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN	Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN	140	1.138167e-04
TF	TF:M00695	Factor: ETF; motif: GVGGMGG	Factor: ETF; motif: GVGGMGG	165	1.324335e-04
TF	TF:M02036_1	Factor: WT1; motif: CGCCCCCNCN; match class: 1	Factor: WT1; motif: CGCCCCCNCN; match class: 1	102	1.464960e-04
TF	TF:M13127_1	Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1	Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1	141	1.631470e-04
TF	TF:M10108_1	Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG; match class: 1	Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG; match class: 1	66	1.804157e-04
TF	TF:M13129_1	Factor: RERE; motif: CNGCNSCNNGSRCRGSGSS; match class: 1	Factor: RERE; motif: CNGCNSCNNGSRCRGSGSS; match class: 1	108	2.012096e-04
TF	TF:M08867_1	Factor: AP2; motif: GCCYGSGGSN; match class: 1	Factor: AP2; motif: GCCYGSGGSN; match class: 1	99	2.538919e-04
TF	TF:M02089_1	Factor: E2F-3; motif: GGCGGGN; match class: 1	Factor: E2F-3; motif: GGCGGGN; match class: 1	152	3.327051e-04
TF	TF:M07039	Factor: ETF; motif: CCCCGCCCCYN	Factor: ETF; motif: CCCCGCCCCYN	221	3.770119e-04
TF	TF:M01199_1	Factor: RNF96; motif: BCCCGCRGCC; match class: 1	Factor: RNF96; motif: BCCCGCRGCC; match class: 1	87	3.895017e-04
TF	TF:M09723	Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS	Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS	159	3.953115e-04
TF	TF:M10086_1	Factor: TAFII250; motif: RARRWGGCGGMGGNGR; match class: 1	Factor: TAFII250; motif: RARRWGGCGGMGGNGR; match class: 1	81	5.787207e-04
TF	TF:M11529	Factor: E2F-2; motif: GCGCGCGCNCS	Factor: E2F-2; motif: GCGCGCGCNCS	220	6.034833e-04
TF	TF:M09984	Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG	Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG	153	6.470781e-04
TF	TF:M11531	Factor: E2F-2; motif: GCGCGCGCGYW	Factor: E2F-2; motif: GCGCGCGCGYW	193	6.980249e-04
TF	TF:M12722	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS	164	8.695008e-04
TF	TF:M07395	Factor: Sp1; motif: NGGGGCGGGGN	Factor: Sp1; motif: NGGGGCGGGGN	165	9.324203e-04
TF	TF:M01104_1	Factor: MOVO-B; motif: GNGGGGG; match class: 1	Factor: MOVO-B; motif: GNGGGGG; match class: 1	104	9.515337e-04
TF	TF:M04953	Factor: Sp1; motif: GGNDGGRGGCGGGG	Factor: Sp1; motif: GGNDGGRGGCGGGG	142	9.903338e-04
TF	TF:M13128	Factor: MED8; motif: CYYNSCYYCCTSCNCC	Factor: MED8; motif: CYYNSCYYCCTSCNCC	187	1.174184e-03
TF	TF:M00196	Factor: Sp1; motif: NGGGGGCGGGGYN	Factor: Sp1; motif: NGGGGGCGGGGYN	160	1.347198e-03
TF	TF:M09826	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC	175	1.453513e-03
TF	TF:M07354	Factor: Egr-1; motif: GCGGGGGCGG	Factor: Egr-1; motif: GCGGGGGCGG	132	1.642312e-03
TF	TF:M12703	Factor: ZNF383; motif: SSNGGGMGGNGSNGGS	Factor: ZNF383; motif: SSNGGGMGGNGSNGGS	146	1.685370e-03
TF	TF:M09826_1	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1	129	1.801378e-03
TF	TF:M07329	Factor: Osx; motif: CCNCCCCCNNN	Factor: Osx; motif: CCNCCCCCNNN	118	2.336552e-03
TF	TF:M09761	Factor: EGR1; motif: NGNGKGGGYGGNGS	Factor: EGR1; motif: NGNGKGGGYGGNGS	96	2.414182e-03
TF	TF:M10432	Factor: MAZ; motif: GGGMGGGGS	Factor: MAZ; motif: GGGMGGGGS	148	2.497146e-03
TF	TF:M09898	Factor: Egr-2; motif: GNGRRNGWGKGGGNGGRG	Factor: Egr-2; motif: GNGRRNGWGKGGGNGGRG	113	3.550111e-03
TF	TF:M07040_1	Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1	Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1	134	3.588515e-03
TF	TF:M02023	Factor: MAZ; motif: NKGGGAGGGGRGGR	Factor: MAZ; motif: NKGGGAGGGGRGGR	121	3.987925e-03
TF	TF:M07354_1	Factor: Egr-1; motif: GCGGGGGCGG; match class: 1	Factor: Egr-1; motif: GCGGGGGCGG; match class: 1	74	4.697335e-03
TF	TF:M07039_1	Factor: ETF; motif: CCCCGCCCCYN; match class: 1	Factor: ETF; motif: CCCCGCCCCYN; match class: 1	194	4.907855e-03
TF	TF:M11601	Factor: TCF-1; motif: ACATCGRGRCGCTGW	Factor: TCF-1; motif: ACATCGRGRCGCTGW	205	5.532331e-03
TF	TF:M08878	Factor: EGR; motif: CGCCCCCGCNN	Factor: EGR; motif: CGCCCCCGCNN	125	5.547791e-03
TF	TF:M11601_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	167	5.623081e-03
TF	TF:M13366	Factor: ZBED4; motif: CCCGCYCCGC	Factor: ZBED4; motif: CCCGCYCCGC	127	6.230958e-03
TF	TF:M08867	Factor: AP2; motif: GCCYGSGGSN	Factor: AP2; motif: GCCYGSGGSN	155	6.262043e-03
TF	TF:M00982	Factor: KROX; motif: CCCGCCCCCRCCCC	Factor: KROX; motif: CCCGCCCCCRCCCC	129	6.336477e-03
TF	TF:M01199	Factor: RNF96; motif: BCCCGCRGCC	Factor: RNF96; motif: BCCCGCRGCC	137	6.582605e-03
TF	TF:M11603_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	189	6.735379e-03
TF	TF:M10072_1	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1	109	6.742228e-03
TF	TF:M01865	Factor: BTEB3; motif: BNRNGGGAGGNGT	Factor: BTEB3; motif: BNRNGGGAGGNGT	153	6.917081e-03
TF	TF:M12351_1	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1	132	7.210126e-03
TF	TF:M08911	Factor: CTCF; motif: NCCRSTAGGGGGCGC	Factor: CTCF; motif: NCCRSTAGGGGGCGC	144	7.236148e-03
TF	TF:M10112	Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR	Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR	139	7.906798e-03
TF	TF:M08441	Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG	Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG	218	8.489190e-03
TF	TF:M08441_1	Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1	Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1	184	9.085178e-03
TF	TF:M01104	Factor: MOVO-B; motif: GNGGGGG	Factor: MOVO-B; motif: GNGGGGG	157	9.885290e-03
TF	TF:M05432	Factor: ZSCAN18; motif: TRRCGRCGNMCC	Factor: ZSCAN18; motif: TRRCGRCGNMCC	79	1.057981e-02
TF	TF:M00915	Factor: AP-2; motif: SNNNCCNCAGGCN	Factor: AP-2; motif: SNNNCCNCAGGCN	149	1.252314e-02
TF	TF:M00986_1	Factor: Churchill; motif: CGGGNN; match class: 1	Factor: Churchill; motif: CGGGNN; match class: 1	158	1.416044e-02
TF	TF:M07289_1	Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1	Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1	160	1.494889e-02
TF	TF:M03567	Factor: Sp2; motif: NYSGCCCCGCCCCCY	Factor: Sp2; motif: NYSGCCCCGCCCCCY	126	1.556468e-02
TF	TF:M11603	Factor: TCF-1; motif: ACATCGRGRCGCTGW	Factor: TCF-1; motif: ACATCGRGRCGCTGW	217	1.760140e-02
TF	TF:M12313	Factor: ZNF460; motif: NNACNCCCCCCNN	Factor: ZNF460; motif: NNACNCCCCCCNN	102	1.770544e-02
TF	TF:M10072	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR	159	1.958271e-02
TF	TF:M13124	Factor: ZNF670; motif: SNGGGCRGRG	Factor: ZNF670; motif: SNGGGCRGRG	183	2.030420e-02
TF	TF:M12742	Factor: ZNF93; motif: GGYAGCRGCAGCGGYG	Factor: ZNF93; motif: GGYAGCRGCAGCGGYG	55	2.197441e-02
TF	TF:M10086	Factor: TAFII250; motif: RARRWGGCGGMGGNGR	Factor: TAFII250; motif: RARRWGGCGGMGGNGR	141	2.245666e-02
TF	TF:M07277	Factor: BTEB2; motif: RGGGNGKGGN	Factor: BTEB2; motif: RGGGNGKGGN	135	2.252476e-02
TF	TF:M10026_1	Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN; match class: 1	Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN; match class: 1	88	2.333267e-02
TF	TF:M01303	Factor: SP1; motif: GGGGYGGGGNS	Factor: SP1; motif: GGGGYGGGGNS	128	2.434649e-02
TF	TF:M00931	Factor: Sp1; motif: GGGGCGGGGC	Factor: Sp1; motif: GGGGCGGGGC	156	2.506717e-02
TF	TF:M09894	Factor: E2F-4; motif: SNGGGCGGGAANN	Factor: E2F-4; motif: SNGGGCGGGAANN	216	2.598855e-02
TF	TF:M09984_1	Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1	Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1	98	2.666071e-02
TF	TF:M08526	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN	221	2.764900e-02
TF	TF:M10071_1	Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1	Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1	85	2.936296e-02
TF	TF:M08526_1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	205	2.954152e-02
TF	TF:M03893_1	Factor: WT1; motif: GNGGGGGCGGGG; match class: 1	Factor: WT1; motif: GNGGGGGCGGGG; match class: 1	76	2.994224e-02
TF	TF:M07226_1	Factor: SP1; motif: NCCCCKCCCCC; match class: 1	Factor: SP1; motif: NCCCCKCCCCC; match class: 1	75	3.218885e-02
TF	TF:M09636	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG	216	3.304000e-02
TF	TF:M12351	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC	177	3.314912e-02
TF	TF:M07208_1	Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1	Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1	49	3.557824e-02
TF	TF:M09723_1	Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1	Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1	103	3.598480e-02
TF	TF:M11531_1	Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1	Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1	178	3.655269e-02
TF	TF:M13144	Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS	Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS	145	3.659033e-02
TF	TF:M12598_1	Factor: E2F3; motif: NNRGMKGGAR; match class: 1	Factor: E2F3; motif: NNRGMKGGAR; match class: 1	115	3.730347e-02
TF	TF:M12158	Factor: KLF15; motif: NCCMCGCCCMCN	Factor: KLF15; motif: NCCMCGCCCMCN	157	4.026108e-02
TF	TF:M08911_1	Factor: CTCF; motif: NCCRSTAGGGGGCGC; match class: 1	Factor: CTCF; motif: NCCRSTAGGGGGCGC; match class: 1	75	4.213477e-02
TF	TF:M10098	Factor: DP-1; motif: NRNNGGCGGGAANN	Factor: DP-1; motif: NRNNGGCGGGAANN	116	4.478588e-02
TF	TF:M07084_1	Factor: E2F-4; motif: NGGCGGGAARN; match class: 1	Factor: E2F-4; motif: NGGCGGGAARN; match class: 1	95	4.809453e-02

HPA

source	term_id	annotation	description	intersection_size	p_value
HPA	HPA:0320000	Nasopharynx	Nasopharynx	148	0.000002
HPA	HPA:0180051	Epididymis; glandular cells[≥Low]	Epididymis; glandular cells[≥Low]	148	0.000014
HPA	HPA:0180000	Epididymis	Epididymis	148	0.000014
HPA	HPA:0050000	Breast	Breast	146	0.000015
HPA	HPA:0130052	Colon; glandular cells[≥Medium]	Colon; glandular cells[≥Medium]	129	0.000023
HPA	HPA:0610831	Urinary bladder; urothelial cells[≥Low]	Urinary bladder; urothelial cells[≥Low]	147	0.000024
HPA	HPA:0610000	Urinary bladder	Urinary bladder	147	0.000024
HPA	HPA:0130051	Colon; glandular cells[≥Low]	Colon; glandular cells[≥Low]	143	0.000025
HPA	HPA:0400051	Rectum; glandular cells[≥Low]	Rectum; glandular cells[≥Low]	143	0.000058
HPA	HPA:0210000	Fallopian tube	Fallopian tube	148	0.000078
HPA	HPA:0020051	Adrenal gland; glandular cells[≥Low]	Adrenal gland; glandular cells[≥Low]	147	0.000101
HPA	HPA:0020000	Adrenal gland	Adrenal gland	147	0.000110
HPA	HPA:0030051	Appendix; glandular cells[≥Low]	Appendix; glandular cells[≥Low]	138	0.000115
HPA	HPA:0380000	Placenta	Placenta	148	0.000139
HPA	HPA:0050051	Breast; glandular cells[≥Low]	Breast; glandular cells[≥Low]	138	0.000240
HPA	HPA:0170000	Endometrium 2	Endometrium 2	139	0.000358
HPA	HPA:0130201	Colon; endothelial cells[≥Low]	Colon; endothelial cells[≥Low]	121	0.000385
HPA	HPA:0550051	Stomach 2; glandular cells[≥Low]	Stomach 2; glandular cells[≥Low]	148	0.000428
HPA	HPA:0550000	Stomach 2	Stomach 2	148	0.000428
HPA	HPA:0150051	Duodenum; glandular cells[≥Low]	Duodenum; glandular cells[≥Low]	141	0.000586
HPA	HPA:0350000	Pancreas	Pancreas	145	0.000592
HPA	HPA:0480000	Small intestine	Small intestine	151	0.000661
HPA	HPA:0480051	Small intestine; glandular cells[≥Low]	Small intestine; glandular cells[≥Low]	140	0.000983
HPA	HPA:0340000	Ovary	Ovary	116	0.001051
HPA	HPA:0320101	Nasopharynx; respiratory epithelial cells[≥Low]	Nasopharynx; respiratory epithelial cells[≥Low]	121	0.001079
HPA	HPA:0050091	Breast; myoepithelial cells[≥Low]	Breast; myoepithelial cells[≥Low]	119	0.001440
HPA	HPA:0100000	Cerebral cortex	Cerebral cortex	153	0.001473
HPA	HPA:0590000	Thyroid gland	Thyroid gland	140	0.001649
HPA	HPA:0590051	Thyroid gland; glandular cells[≥Low]	Thyroid gland; glandular cells[≥Low]	140	0.001649
HPA	HPA:0130241	Colon; peripheral nerve/ganglion[≥Low]	Colon; peripheral nerve/ganglion[≥Low]	109	0.001860
HPA	HPA:0220000	Gallbladder	Gallbladder	147	0.001892
HPA	HPA:0220051	Gallbladder; glandular cells[≥Low]	Gallbladder; glandular cells[≥Low]	147	0.001892
HPA	HPA:0400000	Rectum	Rectum	151	0.002018
HPA	HPA:0090161	Cerebellum; Purkinje cells[≥Low]	Cerebellum; Purkinje cells[≥Low]	117	0.002330
HPA	HPA:0030000	Appendix	Appendix	149	0.002402
HPA	HPA:0480052	Small intestine; glandular cells[≥Medium]	Small intestine; glandular cells[≥Medium]	124	0.003245
HPA	HPA:0130000	Colon	Colon	155	0.003471
HPA	HPA:0090000	Cerebellum	Cerebellum	140	0.003590
HPA	HPA:0351181	Pancreas; pancreatic endocrine cells[≥Low]	Pancreas; pancreatic endocrine cells[≥Low]	117	0.003981
HPA	HPA:0290000	Liver	Liver	127	0.004151
HPA	HPA:0030052	Appendix; glandular cells[≥Medium]	Appendix; glandular cells[≥Medium]	115	0.004380
HPA	HPA:0100201	Cerebral cortex; endothelial cells[≥Low]	Cerebral cortex; endothelial cells[≥Low]	101	0.005311
HPA	HPA:0460000	Skin 1	Skin 1	140	0.005865
HPA	HPA:0100212	Cerebral cortex; neuropil[≥Medium]	Cerebral cortex; neuropil[≥Medium]	66	0.006133
HPA	HPA:0420000	Salivary gland	Salivary gland	135	0.007005
HPA	HPA:0420051	Salivary gland; glandular cells[≥Low]	Salivary gland; glandular cells[≥Low]	135	0.007005
HPA	HPA:0210051	Fallopian tube; glandular cells[≥Low]	Fallopian tube; glandular cells[≥Low]	118	0.007027
HPA	HPA:0130242	Colon; peripheral nerve/ganglion[≥Medium]	Colon; peripheral nerve/ganglion[≥Medium]	80	0.009013
HPA	HPA:0540000	Stomach 1	Stomach 1	145	0.010170
HPA	HPA:0540051	Stomach 1; glandular cells[≥Low]	Stomach 1; glandular cells[≥Low]	145	0.010170
HPA	HPA:0630221	Cervix; squamous epithelial cells[≥Low]	Cervix; squamous epithelial cells[≥Low]	113	0.010233
HPA	HPA:0150000	Duodenum	Duodenum	148	0.011539
HPA	HPA:0430000	Seminal vesicle	Seminal vesicle	133	0.013723
HPA	HPA:0430051	Seminal vesicle; glandular cells[≥Low]	Seminal vesicle; glandular cells[≥Low]	133	0.013723
HPA	HPA:0500651	Soft tissue 1; fibroblasts[≥Low]	Soft tissue 1; fibroblasts[≥Low]	93	0.013964
HPA	HPA:0130202	Colon; endothelial cells[≥Medium]	Colon; endothelial cells[≥Medium]	84	0.016077
HPA	HPA:0150052	Duodenum; glandular cells[≥Medium]	Duodenum; glandular cells[≥Medium]	122	0.018441
HPA	HPA:0170051	Endometrium 2; glandular cells[≥Low]	Endometrium 2; glandular cells[≥Low]	131	0.019717
HPA	HPA:0390051	Prostate; glandular cells[≥Low]	Prostate; glandular cells[≥Low]	130	0.023680
HPA	HPA:0390000	Prostate	Prostate	130	0.023680
HPA	HPA:0550052	Stomach 2; glandular cells[≥Medium]	Stomach 2; glandular cells[≥Medium]	124	0.027692
HPA	HPA:0380522	Placenta; trophoblastic cells[≥Medium]	Placenta; trophoblastic cells[≥Medium]	105	0.028250
HPA	HPA:0610832	Urinary bladder; urothelial cells[≥Medium]	Urinary bladder; urothelial cells[≥Medium]	119	0.029991
HPA	HPA:0460651	Skin 1; fibroblasts[≥Low]	Skin 1; fibroblasts[≥Low]	89	0.032020
HPA	HPA:0270000	Kidney	Kidney	151	0.033834
HPA	HPA:0400052	Rectum; glandular cells[≥Medium]	Rectum; glandular cells[≥Medium]	121	0.034786
HPA	HPA:0600221	Tonsil; squamous epithelial cells[≥Low]	Tonsil; squamous epithelial cells[≥Low]	129	0.035855
HPA	HPA:0590052	Thyroid gland; glandular cells[≥Medium]	Thyroid gland; glandular cells[≥Medium]	113	0.041364
HPA	HPA:0460661	Skin 1; keratinocytes[≥Low]	Skin 1; keratinocytes[≥Low]	106	0.042914
HPA	HPA:0190000	Esophagus	Esophagus	129	0.047001
HPA	HPA:0190221	Esophagus; squamous epithelial cells[≥Low]	Esophagus; squamous epithelial cells[≥Low]	129	0.047001
HPA	HPA:0050052	Breast; glandular cells[≥Medium]	Breast; glandular cells[≥Medium]	105	0.048930

CORUM

source	term_id	annotation	description	intersection_size	p_value
CORUM	CORUM:5177	Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)	Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)	5	0.000029
CORUM	CORUM:4151	TSC (TSC1, TSC2, AXIN, GSK3) complex	TSC (TSC1, TSC2, AXIN, GSK3) complex	4	0.000062
CORUM	CORUM:6353	beta-Catenin destruction complex	beta-Catenin destruction complex	3	0.002629
CORUM	CORUM:3166	AXIN1-APC-CTNNB1-GSK3B complex	AXIN1-APC-CTNNB1-GSK3B complex	3	0.002629
CORUM	CORUM:6963	AXIN1-GID8-GSK3B complex	AXIN1-GID8-GSK3B complex	3	0.002629
CORUM	CORUM:2998	Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex	Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex	3	0.010331
CORUM	CORUM:7159	TSC2-GSK3-AXIN-DVL complex	TSC2-GSK3-AXIN-DVL complex	3	0.010331

HP

source	term_id	annotation	description	intersection_size	p_value
HP	HP:0200040	Epidermoid cyst	Nontender, round and firm, but slightly compressible, intradermal or subcutaneous cyst measuring 0.5-5 cm in diameter. Epidermal cysts are intradermal or subcutaneous tumors, grow slowly and occur on the face, neck, back and scrotum. They usually appear at or around puberty, and as a rule an affected individual has one solitary or a few cysts.	5	0.018174
HP	HP:0002862	Bladder carcinoma	The presence of a carcinoma of the urinary bladder.	6	0.022853
HP	HP:0009725	Bladder neoplasm	The presence of a neoplasm of the urinary bladder.	6	0.027381
HP	HP:0011044	Abnormal number of permanent teeth	The presence of an altered number of of permanent teeth.	6	0.032607
HP	HP:0000006	Autosomal dominant inheritance	A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.	52	0.038091
HP	HP:0005584	Renal cell carcinoma	A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule.	8	0.039443
HP	HP:0006483	Abnormal number of teeth	The presence of an altered number of of teeth.	19	0.039528
HP	HP:0001442	Typified by somatic mosaicism	Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic.	12	0.040377
HP	HP:0006349	Agenesis of permanent teeth	A congenital defect characterized by the absence of one or more permanent teeth, including oligodontia, hypodontia, and adontia of the of permanent teeth.	5	0.049890

Community 1

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	139	1.018692e-46	1
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	175	2.110277e-34	1
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	76	2.865964e-28	1
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	76	2.956202e-28	1
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	76	2.956202e-28	1
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	75	7.977690e-28	1
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	101	1.038963e-27	1
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	79	2.976048e-18	1
GO:CC	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	85	4.003245e-15	1
GO:CC	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	48	4.310389e-15	1
GO:CC	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	28	1.566156e-13	1
GO:CC	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	60	5.086152e-13	1
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	60	2.254908e-12	1
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	60	2.507953e-12	1
GO:CC	GO:0099080	supramolecular complex	"A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]	44	4.075506e-12	1
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	104	4.135019e-12	1
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	104	4.135019e-12	1
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	104	4.135019e-12	1
GO:CC	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	11	5.709695e-12	1
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	177	1.187976e-10	1
GO:CC	GO:0048770	pigment granule	"A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]	14	1.509614e-10	1
GO:CC	GO:0042470	melanosome	"A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]	14	1.509614e-10	1
GO:CC	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	166	7.782562e-10	1
GO:CC	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	46	1.053190e-09	1
GO:CC	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	32	1.890937e-09	1
GO:CC	GO:0099512	supramolecular fiber	"A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos]	34	1.990865e-09	1
GO:CC	GO:0099081	supramolecular polymer	"A polymeric supramolecular structure." [GOC:dos]	34	2.441828e-09	1
GO:CC	GO:0099513	polymeric cytoskeletal fiber	"A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos]	29	7.735812e-09	1
GO:CC	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	79	1.257200e-08	1
GO:CC	GO:0005832	chaperonin-containing T-complex	"A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267]	6	1.612057e-08	1
GO:CC	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	43	1.777341e-08	1
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	170	1.962426e-08	1
GO:CC	GO:1904813	ficolin-1-rich granule lumen	"Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620]	12	1.234207e-07	1
GO:CC	GO:0034774	secretory granule lumen	"The volume enclosed by the membrane of a secretory granule." [GOC:rph]	17	3.937881e-07	1
GO:CC	GO:0060205	cytoplasmic vesicle lumen	"The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles]	17	4.969557e-07	1
GO:CC	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	69	5.069727e-07	1
GO:CC	GO:0031983	vesicle lumen	"The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles]	17	5.203677e-07	1
GO:CC	GO:0044297	cell body	"The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]	21	2.411107e-06	1
GO:CC	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	79	7.092221e-06	1
GO:CC	GO:0101002	ficolin-1-rich granule	"Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154]	12	1.108066e-05	1
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	161	1.129937e-05	1
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	89	1.150750e-05	1
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	89	1.159638e-05	1
GO:CC	GO:0022624	proteasome accessory complex	"A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu]	6	1.228581e-05	1
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	45	1.741767e-05	1
GO:CC	GO:0000502	proteasome complex	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome]	8	2.099654e-05	1
GO:CC	GO:0099503	secretory vesicle	"A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]	28	2.268100e-05	1
GO:CC	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	17	3.487414e-05	1
GO:CC	GO:0016234	inclusion body	"A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]	8	4.151552e-05	1
GO:CC	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	22	5.649871e-05	1
GO:CC	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	24	7.126859e-05	1
GO:CC	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	98	8.244273e-05	1
GO:CC	GO:0002199	zona pellucida receptor complex	"A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732]	4	8.568448e-05	1
GO:CC	GO:0035770	ribonucleoprotein granule	"A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]	13	1.376884e-04	1
GO:CC	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	149	2.165686e-04	1
GO:CC	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	5	2.349152e-04	1
GO:CC	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	23	4.035008e-04	1
GO:CC	GO:0036464	cytoplasmic ribonucleoprotein granule	"A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]	12	4.234858e-04	1
GO:CC	GO:1905369	endopeptidase complex	"A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]	8	5.144889e-04	1
GO:CC	GO:0008540	proteasome regulatory particle, base subcomplex	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	4	5.906674e-04	1
GO:CC	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	113	6.397416e-04	1
GO:CC	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	10	8.634508e-04	1
GO:CC	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	13	9.054369e-04	1
GO:CC	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917]	41	1.348079e-03	1
GO:CC	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	8	1.458461e-03	1
GO:CC	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	12	1.685889e-03	1
GO:CC	GO:0098857	membrane microdomain	"A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it." [PMID:20044567, PMID:26253820]	12	1.805593e-03	1
GO:CC	GO:0035578	azurophil granule lumen	"The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095]	7	2.824104e-03	1
GO:CC	GO:0099522	cytosolic region	"Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos]	5	3.066890e-03	1
GO:CC	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	19	3.365976e-03	1
GO:CC	GO:1905368	peptidase complex	"A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]	8	3.385914e-03	1
GO:CC	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	15	4.560720e-03	1
GO:CC	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	109	5.058413e-03	1
GO:CC	GO:0005775	vacuolar lumen	"The volume enclosed within the vacuolar membrane." [ISBN:0198506732]	9	5.108709e-03	1
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	21	5.197910e-03	1
GO:CC	GO:0000323	lytic vacuole	"A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]	19	5.226328e-03	1
GO:CC	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	19	5.226328e-03	1
GO:CC	GO:0150034	distal axon	"That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468]	11	5.956587e-03	1
GO:CC	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	38	5.992313e-03	1
GO:CC	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	15	6.290090e-03	1
GO:CC	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	20	8.139931e-03	1
GO:CC	GO:0031967	organelle envelope	"A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz]	26	8.448870e-03	1
GO:CC	GO:0042582	azurophil granule	"Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule]	8	1.207096e-02	1
GO:CC	GO:0005766	primary lysosome	"A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194]	8	1.207096e-02	1
GO:CC	GO:0005952	cAMP-dependent protein kinase complex	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [PMID:18178622]	3	1.273004e-02	1
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	13	1.439080e-02	1
GO:CC	GO:0031594	neuromuscular junction	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]	6	1.440123e-02	1
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	13	1.821579e-02	1
GO:CC	GO:1990565	HSP90-CDC37 chaperone complex	"A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." [GOC:bhm, GOC:pad, GOC:PARL, PMID:21855797, PMID:22939624]	2	1.954779e-02	1
GO:CC	GO:0017177	glucosidase II complex	"A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335]	2	1.954779e-02	1
GO:CC	GO:1902687	glucosidase complex	"A protein complex which is capable of glucosidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932]	2	1.954779e-02	1
GO:CC	GO:0034515	proteasome storage granule	"An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:krc, GOC:rb, PMID:18504300, PMID:30204036]	2	1.954779e-02	1
GO:CC	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]	5	2.087930e-02	1
GO:CC	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	22	2.137243e-02	1
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	29	2.307285e-02	1
GO:CC	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	18	2.411648e-02	1
GO:CC	GO:0034663	endoplasmic reticulum chaperone complex	"A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965]	3	2.470726e-02	1
GO:CC	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	16	2.990446e-02	1
GO:CC	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	7	4.294613e-02	1

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	112	3.101467e-27	1
GO:BP	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	25	8.463170e-18	1
GO:BP	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	69	1.386581e-17	1
GO:BP	GO:0006793	phosphorus metabolic process	"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]	69	1.486525e-17	1
GO:BP	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	17	9.185571e-17	1
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	59	2.048837e-16	1
GO:BP	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	41	1.677260e-15	1
GO:BP	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	43	2.107158e-15	1
GO:BP	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	32	7.986223e-15	1
GO:BP	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	58	2.648214e-14	1
GO:BP	GO:0008219	cell death	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]	58	2.906984e-14	1
GO:BP	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	83	8.131261e-14	1
GO:BP	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	69	1.255751e-13	1
GO:BP	GO:0009056	catabolic process	"A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	66	1.760150e-13	1
GO:BP	GO:0043412	macromolecule modification	"The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]	71	2.179187e-13	1
GO:BP	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	13	2.355098e-13	1
GO:BP	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	55	5.996359e-13	1
GO:BP	GO:1903829	positive regulation of protein localization	"Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	29	6.089196e-13	1
GO:BP	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	81	6.194986e-13	1
GO:BP	GO:0009408	response to heat	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]	16	6.662050e-13	1
GO:BP	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	62	9.548257e-13	1
GO:BP	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	53	1.481902e-12	1
GO:BP	GO:0051084	'de novo' post-translational protein folding	"The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb]	12	2.412578e-12	1
GO:BP	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	76	3.171035e-12	1
GO:BP	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	129	6.316493e-12	1
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	39	6.964598e-12	1
GO:BP	GO:0034605	cellular response to heat	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]	13	1.767319e-11	1
GO:BP	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	54	2.544815e-11	1
GO:BP	GO:0043067	regulation of programmed cell death	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	46	2.992889e-11	1
GO:BP	GO:0006753	nucleoside phosphate metabolic process	"The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah]	30	7.049113e-11	1
GO:BP	GO:1900182	positive regulation of protein localization to nucleus	"Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]	14	1.410796e-10	1
GO:BP	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	37	1.505935e-10	1
GO:BP	GO:0009266	response to temperature stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb]	17	2.006169e-10	1
GO:BP	GO:0055086	nucleobase-containing small molecule metabolic process	"The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw]	30	2.043527e-10	1
GO:BP	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	44	2.163562e-10	1
GO:BP	GO:1900180	regulation of protein localization to nucleus	"Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]	16	2.594437e-10	1
GO:BP	GO:0031399	regulation of protein modification process	"Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	37	2.627082e-10	1
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	73	3.586162e-10	1
GO:BP	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	28	4.322800e-10	1
GO:BP	GO:0061919	process utilizing autophagic mechanism	"A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378]	28	4.322800e-10	1
GO:BP	GO:0043069	negative regulation of programmed cell death	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	34	5.147472e-10	1
GO:BP	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	64	5.391885e-10	1
GO:BP	GO:0035966	response to topologically incorrect protein	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf]	16	8.134700e-10	1
GO:BP	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	36	1.006176e-09	1
GO:BP	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	46	1.211982e-09	1
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	42	1.482441e-09	1
GO:BP	GO:0030162	regulation of proteolysis	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]	23	1.540608e-09	1
GO:BP	GO:0009117	nucleotide metabolic process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]	25	1.698620e-09	1
GO:BP	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	31	1.910049e-09	1
GO:BP	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	21	2.364949e-09	1
GO:BP	GO:1901698	response to nitrogen compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	36	3.116181e-09	1
GO:BP	GO:0043254	regulation of protein-containing complex assembly	"Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl]	23	3.255901e-09	1
GO:BP	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	109	4.567371e-09	1
GO:BP	GO:0072521	purine-containing compound metabolic process	"The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	26	4.788554e-09	1
GO:BP	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	32	5.665940e-09	1
GO:BP	GO:0009141	nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	19	5.754524e-09	1
GO:BP	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	38	6.220155e-09	1
GO:BP	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	42	7.006163e-09	1
GO:BP	GO:0034504	protein localization to nucleus	"A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]	20	7.892793e-09	1
GO:BP	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	62	8.131697e-09	1
GO:BP	GO:0048583	regulation of response to stimulus	"Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	74	9.426596e-09	1
GO:BP	GO:0016236	macroautophagy	"The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]	21	1.037677e-08	1
GO:BP	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	39	1.286586e-08	1
GO:BP	GO:1901652	response to peptide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]	33	1.429209e-08	1
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	49	1.593827e-08	1
GO:BP	GO:0009628	response to abiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]	36	1.635441e-08	1
GO:BP	GO:0033365	protein localization to organelle	"A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]	37	1.794445e-08	1
GO:BP	GO:0051086	chaperone mediated protein folding independent of cofactor	"The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb]	6	1.851054e-08	1
GO:BP	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	90	1.996669e-08	1
GO:BP	GO:0009199	ribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	18	2.009982e-08	1
GO:BP	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	97	2.117853e-08	1
GO:BP	GO:0070887	cellular response to chemical stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]	51	2.944752e-08	1
GO:BP	GO:0006986	response to unfolded protein	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]	14	3.219277e-08	1
GO:BP	GO:0006163	purine nucleotide metabolic process	"The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	22	3.693189e-08	1
GO:BP	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	93	3.981161e-08	1
GO:BP	GO:1903050	regulation of proteolysis involved in protein catabolic process	"Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]	17	4.126393e-08	1
GO:BP	GO:0034097	response to cytokine	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl]	32	4.597312e-08	1
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	39	5.030138e-08	1
GO:BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	"Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	17	5.040821e-08	1
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	58	5.239713e-08	1
GO:BP	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	33	5.348383e-08	1
GO:BP	GO:1904874	positive regulation of telomerase RNA localization to Cajal body	"Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	6	5.513770e-08	1
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	58	6.242143e-08	1
GO:BP	GO:1901873	regulation of post-translational protein modification	"Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]	17	6.992448e-08	1
GO:BP	GO:0070201	regulation of establishment of protein localization	"Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]	24	7.061052e-08	1
GO:BP	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	87	7.800145e-08	1
GO:BP	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	8	8.829738e-08	1
GO:BP	GO:0016241	regulation of macroautophagy	"Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc]	15	1.135638e-07	1
GO:BP	GO:0009259	ribonucleotide metabolic process	"The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	20	1.338032e-07	1
GO:BP	GO:1904869	regulation of protein localization to Cajal body	"Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	6	1.368665e-07	1
GO:BP	GO:1904871	positive regulation of protein localization to Cajal body	"Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	6	1.368665e-07	1
GO:BP	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	35	1.782000e-07	1
GO:BP	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	16	1.861806e-07	1
GO:BP	GO:0009144	purine nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	17	1.895771e-07	1
GO:BP	GO:0019693	ribose phosphate metabolic process	"The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]	20	1.952457e-07	1
GO:BP	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	58	2.207555e-07	1
GO:BP	GO:0019637	organophosphate metabolic process	"The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]	33	2.788201e-07	1
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	62	3.070561e-07	1
GO:BP	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	88	3.252558e-07	1
GO:BP	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	90	3.417884e-07	1
GO:BP	GO:0019941	modification-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]	25	4.311265e-07	1
GO:BP	GO:0043632	modification-dependent macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl]	25	5.072309e-07	1
GO:BP	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	23	5.354278e-07	1
GO:BP	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]	145	5.902720e-07	1
GO:BP	GO:1904872	regulation of telomerase RNA localization to Cajal body	"Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	6	5.937014e-07	1
GO:BP	GO:1904867	protein localization to Cajal body	"A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	6	5.937014e-07	1
GO:BP	GO:1903405	protein localization to nuclear body	"A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849]	6	5.937014e-07	1
GO:BP	GO:0051234	establishment of localization	"Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]	80	7.254496e-07	1
GO:BP	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	19	7.760204e-07	1
GO:BP	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	64	8.217624e-07	1
GO:BP	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	64	9.052606e-07	1
GO:BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	16	1.123490e-06	1
GO:BP	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	65	1.200840e-06	1
GO:BP	GO:0019220	regulation of phosphate metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	30	1.231897e-06	1
GO:BP	GO:0045862	positive regulation of proteolysis	"Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]	15	1.233316e-06	1
GO:BP	GO:0051174	regulation of phosphorus metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]	30	1.262662e-06	1
GO:BP	GO:0033043	regulation of organelle organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]	33	1.426654e-06	1
GO:BP	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	24	1.681887e-06	1
GO:BP	GO:0051131	chaperone-mediated protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]	7	1.699170e-06	1
GO:BP	GO:0032212	positive regulation of telomere maintenance via telomerase	"Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]	7	1.699170e-06	1
GO:BP	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	141	1.848676e-06	1
GO:BP	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	28	1.868083e-06	1
GO:BP	GO:1990173	protein localization to nucleoplasm	"A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952]	6	1.902265e-06	1
GO:BP	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	58	1.917604e-06	1
GO:BP	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	25	1.928395e-06	1
GO:BP	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	32	2.243421e-06	1
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	44	2.349896e-06	1
GO:BP	GO:0009150	purine ribonucleotide metabolic process	"The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	18	2.670069e-06	1
GO:BP	GO:0061136	regulation of proteasomal protein catabolic process	"Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb]	14	3.072595e-06	1
GO:BP	GO:0031396	regulation of protein ubiquitination	"Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	14	3.072595e-06	1
GO:BP	GO:0007049	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]	40	3.167134e-06	1
GO:BP	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	38	3.613277e-06	1
GO:BP	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]	12	4.006290e-06	1
GO:BP	GO:1904358	positive regulation of telomere maintenance via telomere lengthening	"Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]	7	4.266321e-06	1
GO:BP	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194]	28	4.896055e-06	1
GO:BP	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	18	5.878500e-06	1
GO:BP	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	24	6.020794e-06	1
GO:BP	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	30	6.548477e-06	1
GO:BP	GO:0051050	positive regulation of transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	27	7.030171e-06	1
GO:BP	GO:0070647	protein modification by small protein conjugation or removal	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah]	29	8.278443e-06	1
GO:BP	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	93	8.412202e-06	1
GO:BP	GO:0051169	nuclear transport	"The directed movement of substances into, out of, or within the nucleus." [GOC:ai]	17	8.741636e-06	1
GO:BP	GO:0006913	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	17	8.741636e-06	1
GO:BP	GO:0002682	regulation of immune system process	"Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]	38	9.065992e-06	1
GO:BP	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	49	9.147197e-06	1
GO:BP	GO:0018193	peptidyl-amino acid modification	"The alteration of an amino acid residue in a peptide." [GOC:mah]	24	9.530934e-06	1
GO:BP	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	29	9.937451e-06	1
GO:BP	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	145	1.241502e-05	1
GO:BP	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	142	1.254327e-05	1
GO:BP	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	29	1.423460e-05	1
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	59	1.464606e-05	1
GO:BP	GO:0044419	biological process involved in interspecies interaction between organisms	"Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]	40	1.565693e-05	1
GO:BP	GO:0090685	RNA localization to nucleus	"A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931]	6	1.658640e-05	1
GO:BP	GO:0090672	telomerase RNA localization	"Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]	6	1.658640e-05	1
GO:BP	GO:0090670	RNA localization to Cajal body	"A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]	6	1.658640e-05	1
GO:BP	GO:0090671	telomerase RNA localization to Cajal body	"A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]	6	1.658640e-05	1
GO:BP	GO:0010638	positive regulation of organelle organization	"Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]	20	1.687277e-05	1
GO:BP	GO:0009896	positive regulation of catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	21	1.842131e-05	1
GO:BP	GO:0046034	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	14	2.132758e-05	1
GO:BP	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	23	2.264398e-05	1
GO:BP	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	15	2.287216e-05	1
GO:BP	GO:0019362	pyridine nucleotide metabolic process	"The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl]	12	2.927836e-05	1
GO:BP	GO:0046496	nicotinamide nucleotide metabolic process	"The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732]	12	2.927836e-05	1
GO:BP	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	27	2.967709e-05	1
GO:BP	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	107	3.407016e-05	1
GO:BP	GO:0070585	protein localization to mitochondrion	"A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd]	11	3.480890e-05	1
GO:BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	18	3.503692e-05	1
GO:BP	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	26	3.511150e-05	1
GO:BP	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	28	4.088535e-05	1
GO:BP	GO:0051258	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	15	4.489365e-05	1
GO:BP	GO:0072524	pyridine-containing compound metabolic process	"The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]	12	4.700995e-05	1
GO:BP	GO:1904951	positive regulation of establishment of protein localization	"Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	16	4.794064e-05	1
GO:BP	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	70	5.147258e-05	1
GO:BP	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	96	5.361403e-05	1
GO:BP	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	22	5.509868e-05	1
GO:BP	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	12	5.719326e-05	1
GO:BP	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	86	6.081895e-05	1
GO:BP	GO:0044281	small molecule metabolic process	"The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	39	6.490760e-05	1
GO:BP	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	12	6.503841e-05	1
GO:BP	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	40	6.634137e-05	1
GO:BP	GO:0051129	negative regulation of cellular component organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	23	6.670014e-05	1
GO:BP	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	73	7.072033e-05	1
GO:BP	GO:0009607	response to biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]	37	7.198122e-05	1
GO:BP	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	18	7.444675e-05	1
GO:BP	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	26	7.684208e-05	1
GO:BP	GO:0007004	telomere maintenance via telomerase	"The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh]	8	8.000947e-05	1
GO:BP	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419]	24	8.213360e-05	1
GO:BP	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	10	8.838065e-05	1
GO:BP	GO:1902531	regulation of intracellular signal transduction	"Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	41	9.303770e-05	1
GO:BP	GO:0023057	negative regulation of signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	34	9.712823e-05	1
GO:BP	GO:0010648	negative regulation of cell communication	"Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	34	9.877351e-05	1
GO:BP	GO:0070841	inclusion body assembly	"The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah]	6	1.037447e-04	1
GO:BP	GO:0031400	negative regulation of protein modification process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	16	1.085867e-04	1
GO:BP	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	34	1.129103e-04	1
GO:BP	GO:0046822	regulation of nucleocytoplasmic transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]	10	1.135783e-04	1
GO:BP	GO:0051707	response to other organism	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai]	36	1.183260e-04	1
GO:BP	GO:0006278	RNA-templated DNA biosynthetic process	"A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732]	8	1.184910e-04	1
GO:BP	GO:0043207	response to external biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators]	36	1.240366e-04	1
GO:BP	GO:0043436	oxoacid metabolic process	"The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid]	26	1.248681e-04	1
GO:BP	GO:0018209	peptidyl-serine modification	"The modification of peptidyl-serine." [GOC:go_curators]	12	1.359140e-04	1
GO:BP	GO:0032386	regulation of intracellular transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	14	1.397589e-04	1
GO:BP	GO:0006082	organic acid metabolic process	"The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]	26	1.421524e-04	1
GO:BP	GO:0080134	regulation of response to stress	"Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	33	1.435451e-04	1
GO:BP	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	37	1.466146e-04	1
GO:BP	GO:0071840	cellular component organization or biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]	107	1.597485e-04	1
GO:BP	GO:0051640	organelle localization	"Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]	21	1.615373e-04	1
GO:BP	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	90	1.631842e-04	1
GO:BP	GO:0072655	establishment of protein localization to mitochondrion	"The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah]	10	1.983865e-04	1
GO:BP	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	45	2.077663e-04	1
GO:BP	GO:0032210	regulation of telomere maintenance via telomerase	"Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]	7	2.242174e-04	1
GO:BP	GO:0009185	ribonucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	10	2.492080e-04	1
GO:BP	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	31	2.571401e-04	1
GO:BP	GO:0032870	cellular response to hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah]	21	2.605562e-04	1
GO:BP	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	26	2.784226e-04	1
GO:BP	GO:0140546	defense response to symbiont	"Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg]	28	2.965859e-04	1
GO:BP	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	89	3.029287e-04	1
GO:BP	GO:0046785	microtubule polymerization	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]	9	3.061936e-04	1
GO:BP	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	21	3.123140e-04	1
GO:BP	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	12	3.171235e-04	1
GO:BP	GO:0042325	regulation of phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]	24	3.453088e-04	1
GO:BP	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	11	3.684905e-04	1
GO:BP	GO:0010833	telomere maintenance via telomere lengthening	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb]	8	3.823934e-04	1
GO:BP	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	28	4.077159e-04	1
GO:BP	GO:0051085	chaperone cofactor-dependent protein refolding	"The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]	6	4.133140e-04	1
GO:BP	GO:0009132	nucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	10	4.145549e-04	1
GO:BP	GO:1903578	regulation of ATP metabolic process	"Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849]	8	4.256361e-04	1
GO:BP	GO:0001932	regulation of protein phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]	23	4.417443e-04	1
GO:BP	GO:0051656	establishment of organelle localization	"The directed movement of an organelle to a specific location." [GOC:ai]	18	4.533205e-04	1
GO:BP	GO:0141124	intracellular signaling cassette	"An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg]	39	4.534983e-04	1
GO:BP	GO:2000573	positive regulation of DNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	7	4.678261e-04	1
GO:BP	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	11	4.686860e-04	1
GO:BP	GO:0032206	positive regulation of telomere maintenance	"Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]	8	4.730046e-04	1
GO:BP	GO:0043434	response to peptide hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]	17	4.781980e-04	1
GO:BP	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	12	4.837192e-04	1
GO:BP	GO:0051170	import into nucleus	"The directed movement of substances into the nucleus." [GOC:ai]	11	4.972232e-04	1
GO:BP	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	39	5.257324e-04	1
GO:BP	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	31	5.578685e-04	1
GO:BP	GO:0022411	cellular component disassembly	"A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete]	17	5.782933e-04	1
GO:BP	GO:0008152	metabolic process	"A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	151	5.831750e-04	1
GO:BP	GO:0031109	microtubule polymerization or depolymerization	"Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]	10	5.854129e-04	1
GO:BP	GO:0097435	supramolecular fiber organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr]	24	6.712419e-04	1
GO:BP	GO:0009719	response to endogenous stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]	33	7.353929e-04	1
GO:BP	GO:0035967	cellular response to topologically incorrect protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf]	9	7.653332e-04	1
GO:BP	GO:0009891	positive regulation of biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	48	7.960610e-04	1
GO:BP	GO:1904356	regulation of telomere maintenance via telomere lengthening	"Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]	7	7.967068e-04	1
GO:BP	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	33	8.175906e-04	1
GO:BP	GO:1903047	mitotic cell cycle process	"A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]	22	8.234194e-04	1
GO:BP	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	70	8.424962e-04	1
GO:BP	GO:0046649	lymphocyte activation	"A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]	23	9.517908e-04	1
GO:BP	GO:0009895	negative regulation of catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	15	1.005518e-03	1
GO:BP	GO:1901293	nucleoside phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie]	14	1.054243e-03	1
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	14	1.095128e-03	1
GO:BP	GO:0043933	protein-containing complex organization	"Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah]	56	1.120554e-03	1
GO:BP	GO:0032868	response to insulin	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	13	1.143385e-03	1
GO:BP	GO:1900542	regulation of purine nucleotide metabolic process	"Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie]	8	1.144810e-03	1
GO:BP	GO:1904375	regulation of protein localization to cell periphery	"Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]	10	1.192135e-03	1
GO:BP	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	40	1.252526e-03	1
GO:BP	GO:0006140	regulation of nucleotide metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]	8	1.254596e-03	1
GO:BP	GO:1901654	response to ketone	"A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676]	12	1.285330e-03	1
GO:BP	GO:0051049	regulation of transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	34	1.382097e-03	1
GO:BP	GO:0033157	regulation of intracellular protein transport	"Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah]	10	1.432245e-03	1
GO:BP	GO:0034330	cell junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]	23	1.446644e-03	1
GO:BP	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	82	1.493621e-03	1
GO:BP	GO:0006091	generation of precursor metabolites and energy	"The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]	17	1.512899e-03	1
GO:BP	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	24	1.730661e-03	1
GO:BP	GO:0002764	immune response-regulating signaling pathway	"The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]	18	1.798822e-03	1
GO:BP	GO:0045321	leukocyte activation	"A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add]	25	1.915924e-03	1
GO:BP	GO:0098542	defense response to other organism	"Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]	29	2.050943e-03	1
GO:BP	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	94	2.147467e-03	1
GO:BP	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	19	2.205237e-03	1
GO:BP	GO:0032271	regulation of protein polymerization	"Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]	11	2.247256e-03	1
GO:BP	GO:0045931	positive regulation of mitotic cell cycle	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	9	2.282262e-03	1
GO:BP	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	9	2.282262e-03	1
GO:BP	GO:0032273	positive regulation of protein polymerization	"Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]	8	2.306214e-03	1
GO:BP	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	27	2.466617e-03	1
GO:BP	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	24	2.536987e-03	1
GO:BP	GO:0009166	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	10	2.564851e-03	1
GO:BP	GO:0051223	regulation of protein transport	"Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	16	2.571282e-03	1
GO:BP	GO:0051248	negative regulation of protein metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]	20	2.840030e-03	1
GO:BP	GO:0043086	negative regulation of catalytic activity	"Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	13	2.856905e-03	1
GO:BP	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	8	2.946655e-03	1
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	18	3.015894e-03	1
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]	18	3.015894e-03	1
GO:BP	GO:0002253	activation of immune response	"Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]	18	3.015894e-03	1
GO:BP	GO:0044085	cellular component biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]	71	3.129721e-03	1
GO:BP	GO:0007051	spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah]	11	3.152110e-03	1
GO:BP	GO:0071495	cellular response to endogenous stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]	28	3.410580e-03	1
GO:BP	GO:0046032	ADP catabolic process	"The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators]	8	3.452936e-03	1
GO:BP	GO:1903322	positive regulation of protein modification by small protein conjugation or removal	"Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	9	3.612601e-03	1
GO:BP	GO:0030705	cytoskeleton-dependent intracellular transport	"The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]	11	3.628950e-03	1
GO:BP	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	26	3.766094e-03	1
GO:BP	GO:1901875	positive regulation of post-translational protein modification	"Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]	9	3.848678e-03	1
GO:BP	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	86	3.983072e-03	1
GO:BP	GO:0019364	pyridine nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw]	8	4.031397e-03	1
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	"Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	45	4.161931e-03	1
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]	13	4.294288e-03	1
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	13	4.294288e-03	1
GO:BP	GO:0001558	regulation of cell growth	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	15	4.335970e-03	1
GO:BP	GO:0009181	purine ribonucleoside diphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	4.350237e-03	1
GO:BP	GO:0009137	purine nucleoside diphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	4.350237e-03	1
GO:BP	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	61	4.481739e-03	1
GO:BP	GO:0051222	positive regulation of protein transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	12	4.485394e-03	1
GO:BP	GO:0034975	protein folding in endoplasmic reticulum	"A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw]	4	4.513348e-03	1
GO:BP	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	17	4.627419e-03	1
GO:BP	GO:0072526	pyridine-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]	8	5.052596e-03	1
GO:BP	GO:0050807	regulation of synapse organization	"Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]	13	5.137653e-03	1
GO:BP	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	52	5.375871e-03	1
GO:BP	GO:0009191	ribonucleoside diphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	5.438434e-03	1
GO:BP	GO:0006195	purine nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	9	5.563834e-03	1
GO:BP	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	8	5.849004e-03	1
GO:BP	GO:0046031	ADP metabolic process	"The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators]	8	5.849004e-03	1
GO:BP	GO:0023056	positive regulation of signaling	"Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	35	6.049522e-03	1
GO:BP	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	8	6.285583e-03	1
GO:BP	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	8	6.285583e-03	1
GO:BP	GO:0050803	regulation of synapse structure or activity	"Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]	13	6.564713e-03	1
GO:BP	GO:0034655	nucleobase-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	17	6.941413e-03	1
GO:BP	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	47	7.015567e-03	1
GO:BP	GO:0009134	nucleoside diphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	7.242138e-03	1
GO:BP	GO:0016049	cell growth	"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]	16	8.461065e-03	1
GO:BP	GO:1901292	nucleoside phosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie]	10	8.467846e-03	1
GO:BP	GO:0097191	extrinsic apoptotic signaling pathway	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]	11	9.134545e-03	1
GO:BP	GO:0034614	cellular response to reactive oxygen species	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]	9	9.353252e-03	1
GO:BP	GO:2001233	regulation of apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	14	9.836321e-03	1
GO:BP	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	11	9.921258e-03	1
GO:BP	GO:0032204	regulation of telomere maintenance	"Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]	8	1.018812e-02	1
GO:BP	GO:0002757	immune response-activating signaling pathway	"The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add]	16	1.067061e-02	1
GO:BP	GO:0044092	negative regulation of molecular function	"Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]	17	1.075081e-02	1
GO:BP	GO:1902903	regulation of supramolecular fiber organization	"Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]	14	1.076021e-02	1
GO:BP	GO:0051646	mitochondrion localization	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	6	1.102548e-02	1
GO:BP	GO:0090666	scaRNA localization to Cajal body	"A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]	3	1.128347e-02	1
GO:BP	GO:0032787	monocarboxylic acid metabolic process	"The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]	18	1.135530e-02	1
GO:BP	GO:0009135	purine nucleoside diphosphate metabolic process	"The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	1.322277e-02	1
GO:BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	1.322277e-02	1
GO:BP	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	17	1.359794e-02	1
GO:BP	GO:0044089	positive regulation of cellular component biogenesis	"Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	16	1.406443e-02	1
GO:BP	GO:0072523	purine-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	9	1.440128e-02	1
GO:BP	GO:0045088	regulation of innate immune response	"Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]	15	1.463435e-02	1
GO:BP	GO:0010647	positive regulation of cell communication	"Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	34	1.584004e-02	1
GO:BP	GO:0050778	positive regulation of immune response	"Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	20	1.601607e-02	1
GO:BP	GO:0000302	response to reactive oxygen species	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc]	10	1.612891e-02	1
GO:BP	GO:0006206	pyrimidine nucleobase metabolic process	"The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]	4	1.615540e-02	1
GO:BP	GO:0006403	RNA localization	"A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]	10	1.685356e-02	1
GO:BP	GO:0051346	negative regulation of hydrolase activity	"Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]	7	1.687960e-02	1
GO:BP	GO:1905897	regulation of response to endoplasmic reticulum stress	"Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]	7	1.687960e-02	1
GO:BP	GO:0006734	NADH metabolic process	"The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	5	1.832422e-02	1
GO:BP	GO:0009112	nucleobase metabolic process	"The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma]	5	1.832422e-02	1
GO:BP	GO:0051654	establishment of mitochondrion localization	"The directed movement of the mitochondrion to a specific location." [GOC:ai]	5	1.832422e-02	1
GO:BP	GO:0071353	cellular response to interleukin-4	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah]	5	1.832422e-02	1
GO:BP	GO:0019221	cytokine-mediated signaling pathway	"The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629]	16	1.929691e-02	1
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc]	18	1.991041e-02	1
GO:BP	GO:0042110	T cell activation	"The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149]	17	2.093101e-02	1
GO:BP	GO:0010639	negative regulation of organelle organization	"Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]	13	2.098015e-02	1
GO:BP	GO:0046112	nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai]	4	2.098521e-02	1
GO:BP	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	131	2.105050e-02	1
GO:BP	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	9	2.270871e-02	1
GO:BP	GO:0032869	cellular response to insulin stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	10	2.276046e-02	1
GO:BP	GO:0072384	organelle transport along microtubule	"The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]	7	2.280628e-02	1
GO:BP	GO:0016242	negative regulation of macroautophagy	"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]	5	2.448475e-02	1
GO:BP	GO:0002218	activation of innate immune response	"Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]	12	2.458522e-02	1
GO:BP	GO:0042306	regulation of protein import into nucleus	"Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl]	6	2.519805e-02	1
GO:BP	GO:0032984	protein-containing complex disassembly	"The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah]	11	2.604575e-02	1
GO:BP	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	11	2.604575e-02	1
GO:BP	GO:0031929	TOR signaling	"The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]	9	2.626049e-02	1
GO:BP	GO:2000278	regulation of DNA biosynthetic process	"Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	7	2.636025e-02	1
GO:BP	GO:0071218	cellular response to misfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]	4	2.680084e-02	1
GO:BP	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	12	2.710166e-02	1
GO:BP	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	46	2.763900e-02	1
GO:BP	GO:0031344	regulation of cell projection organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]	18	2.770324e-02	1
GO:BP	GO:0070670	response to interleukin-4	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah]	5	2.811508e-02	1
GO:BP	GO:0010507	negative regulation of autophagy	"Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	7	2.830196e-02	1
GO:BP	GO:0009154	purine ribonucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	8	2.886957e-02	1
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	"Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626]	9	2.888271e-02	1
GO:BP	GO:0040007	growth	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]	22	2.894763e-02	1
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	18	3.003593e-02	1
GO:BP	GO:0034620	cellular response to unfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]	7	3.036042e-02	1
GO:BP	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	8	3.054042e-02	1
GO:BP	GO:0009889	regulation of biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	76	3.081991e-02	1
GO:BP	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	30	3.211250e-02	1
GO:BP	GO:0040008	regulation of growth	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]	17	3.369714e-02	1
GO:BP	GO:0048311	mitochondrion distribution	"Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]	4	3.372114e-02	1
GO:BP	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	15	3.456628e-02	1
GO:BP	GO:0062197	cellular response to chemical stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712]	12	3.605187e-02	1
GO:BP	GO:0046824	positive regulation of nucleocytoplasmic transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]	6	3.643844e-02	1
GO:BP	GO:0051648	vesicle localization	"Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai]	10	3.706741e-02	1
GO:BP	GO:0002221	pattern recognition receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]	11	3.712546e-02	1
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	"Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	36	3.719366e-02	1
GO:BP	GO:0090316	positive regulation of intracellular protein transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	7	3.729143e-02	1
GO:BP	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	8	3.806064e-02	1
GO:BP	GO:0048312	intracellular distribution of mitochondria	"Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]	3	3.899546e-02	1
GO:BP	GO:0009260	ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	9	3.989133e-02	1
GO:BP	GO:0007339	binding of sperm to zona pellucida	"The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437]	5	4.156862e-02	1
GO:BP	GO:0051788	response to misfolded protein	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:go_curators]	4	4.187014e-02	1
GO:BP	GO:0051090	regulation of DNA-binding transcription factor activity	"Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	12	4.206138e-02	1
GO:BP	GO:0009261	ribonucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	8	4.236816e-02	1
GO:BP	GO:0010970	transport along microtubule	"The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb]	9	4.362494e-02	1

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	135	3.673420e-27	1
GO:MF	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	18	5.957835e-27	1
GO:MF	GO:0017076	purine nucleotide binding	"Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]	74	1.421365e-22	1
GO:MF	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	64	1.738483e-22	1
GO:MF	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	76	3.793073e-22	1
GO:MF	GO:1901265	nucleoside phosphate binding	"Binding to nucleoside phosphate." [GOC:TermGenie]	76	6.081184e-22	1
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	71	6.478389e-22	1
GO:MF	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	19	5.900370e-21	1
GO:MF	GO:0032555	purine ribonucleotide binding	"Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	70	1.116566e-20	1
GO:MF	GO:0035639	purine ribonucleoside triphosphate binding	"Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732]	69	1.204814e-20	1
GO:MF	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	60	1.301553e-20	1
GO:MF	GO:0032553	ribonucleotide binding	"Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	70	1.767656e-20	1
GO:MF	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	76	1.784481e-20	1
GO:MF	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	59	2.027390e-20	1
GO:MF	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	72	6.657985e-18	1
GO:MF	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	28	1.246295e-17	1
GO:MF	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	73	3.856768e-17	1
GO:MF	GO:0044389	ubiquitin-like protein ligase binding	"Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]	28	5.817787e-17	1
GO:MF	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	17	1.201552e-13	1
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	174	5.868788e-13	1
GO:MF	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	66	1.734943e-11	1
GO:MF	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	16	2.798288e-11	1
GO:MF	GO:0036094	small molecule binding	"Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]	105	4.781684e-10	1
GO:MF	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	27	6.839959e-09	1
GO:MF	GO:0043167	ion binding	"Binding to an ion, a charged atoms or groups of atoms." [GOC:jl]	100	1.157713e-08	1
GO:MF	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	29	4.668991e-08	1
GO:MF	GO:0106310	protein serine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989]	20	4.926304e-08	1
GO:MF	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	29	6.294085e-08	1
GO:MF	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	21	7.579732e-08	1
GO:MF	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	64	8.300099e-08	1
GO:MF	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925]	24	1.090806e-07	1
GO:MF	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	27	1.451887e-07	1
GO:MF	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	32	1.626717e-07	1
GO:MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-]	30	2.859532e-07	1
GO:MF	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	49	3.656743e-07	1
GO:MF	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-]	54	5.740051e-07	1
GO:MF	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	36	7.337566e-07	1
GO:MF	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	35	9.299302e-07	1
GO:MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	35	9.494354e-07	1
GO:MF	GO:0016817	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	35	9.494354e-07	1
GO:MF	GO:0017111	ribonucleoside triphosphate phosphatase activity	"Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680]	34	1.006825e-06	1
GO:MF	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	6	2.138547e-06	1
GO:MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	33	2.272802e-06	1
GO:MF	GO:0097718	disordered domain specific binding	"Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698]	7	3.271202e-06	1
GO:MF	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	23	1.303314e-05	1
GO:MF	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	32	1.725700e-05	1
GO:MF	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	180	5.127214e-05	1
GO:MF	GO:0048156	tau protein binding	"Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]	7	6.081384e-05	1
GO:MF	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	7	7.177980e-05	1
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	15	2.134533e-04	1
GO:MF	GO:0098772	molecular function regulator activity	"A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt]	43	2.789999e-04	1
GO:MF	GO:0030674	protein-macromolecule adaptor activity	"An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	27	3.034075e-04	1
GO:MF	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	26	5.602231e-04	1
GO:MF	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-]	22	7.160766e-04	1
GO:MF	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	11	7.380903e-04	1
GO:MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-]	9	1.061079e-03	1
GO:MF	GO:0030060	L-malate dehydrogenase (NAD+) activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [RHEA:21432]	3	1.738352e-03	1
GO:MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	9	2.021817e-03	1
GO:MF	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	9	2.021817e-03	1
GO:MF	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-]	10	2.580800e-03	1
GO:MF	GO:0051020	GTPase binding	"Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	13	3.479954e-03	1
GO:MF	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	9	3.864192e-03	1
GO:MF	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	12	5.366961e-03	1
GO:MF	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	14	7.295434e-03	1
GO:MF	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	17	7.731525e-03	1
GO:MF	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	8	8.091648e-03	1
GO:MF	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	25	1.410130e-02	1
GO:MF	GO:0030235	nitric-oxide synthase regulator activity	"Binds to and modulates the activity of nitric oxide synthase." [GOC:mah]	3	1.491353e-02	1
GO:MF	GO:0030911	TPR domain binding	"Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah]	3	1.491353e-02	1
GO:MF	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	19	1.849372e-02	1
GO:MF	GO:0016615	malate dehydrogenase activity	"Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]	3	2.370542e-02	1
GO:MF	GO:0004712	protein serine/threonine/tyrosine kinase activity	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]	5	2.434329e-02	1
GO:MF	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	27	3.446658e-02	1
GO:MF	GO:0023026	MHC class II protein complex binding	"Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw]	4	3.536073e-02	1
GO:MF	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	7	4.571219e-02	1

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0340461	Ovary; ovarian stroma cells[≥Low]	Ovary; ovarian stroma cells[≥Low]	105	1.418738e-13	1
HPA	HPA:0530721	Spleen; cells in white pulp[≥Low]	Spleen; cells in white pulp[≥Low]	108	2.327407e-12	1
HPA	HPA:0600432	Tonsil; germinal center cells[≥Medium]	Tonsil; germinal center cells[≥Medium]	104	4.806774e-12	1
HPA	HPA:0600431	Tonsil; germinal center cells[≥Low]	Tonsil; germinal center cells[≥Low]	127	3.915562e-11	1
HPA	HPA:0050051	Breast; glandular cells[≥Low]	Breast; glandular cells[≥Low]	136	3.939792e-11	1
HPA	HPA:0340000	Ovary	Ovary	120	5.856848e-11	1
HPA	HPA:0301371	Lung; alveolar cells type II[≥Low]	Lung; alveolar cells type II[≥Low]	57	1.452215e-10	1
HPA	HPA:0050000	Breast	Breast	138	6.059114e-10	1
HPA	HPA:0530000	Spleen	Spleen	123	1.872724e-09	1
HPA	HPA:0471391	Skin 2; cells in basal layer[≥Low]	Skin 2; cells in basal layer[≥Low]	42	3.144260e-09	1
HPA	HPA:0160051	Endometrium 1; glandular cells[≥Low]	Endometrium 1; glandular cells[≥Low]	133	3.491619e-09	1
HPA	HPA:0301372	Lung; alveolar cells type II[≥Medium]	Lung; alveolar cells type II[≥Medium]	48	4.295650e-09	1
HPA	HPA:0600441	Tonsil; non-germinal center cells[≥Low]	Tonsil; non-germinal center cells[≥Low]	125	4.385101e-09	1
HPA	HPA:0170052	Endometrium 2; glandular cells[≥Medium]	Endometrium 2; glandular cells[≥Medium]	109	6.553196e-09	1
HPA	HPA:0310000	Lymph node	Lymph node	129	1.023364e-08	1
HPA	HPA:0170051	Endometrium 2; glandular cells[≥Low]	Endometrium 2; glandular cells[≥Low]	131	1.282136e-08	1
HPA	HPA:0090000	Cerebellum	Cerebellum	136	1.357189e-08	1
HPA	HPA:0460201	Skin 1; endothelial cells[≥Low]	Skin 1; endothelial cells[≥Low]	38	1.435404e-08	1
HPA	HPA:0310441	Lymph node; non-germinal center cells[≥Low]	Lymph node; non-germinal center cells[≥Low]	123	2.078165e-08	1
HPA	HPA:0310431	Lymph node; germinal center cells[≥Low]	Lymph node; germinal center cells[≥Low]	110	2.652106e-08	1
HPA	HPA:0180052	Epididymis; glandular cells[≥Medium]	Epididymis; glandular cells[≥Medium]	118	3.295147e-08	1
HPA	HPA:0160251	Endometrium 1; cells in endometrial stroma[≥Low]	Endometrium 1; cells in endometrial stroma[≥Low]	96	3.741044e-08	1
HPA	HPA:0471461	Skin 2; langerhans cells[≥Low]	Skin 2; langerhans cells[≥Low]	36	3.983570e-08	1
HPA	HPA:0210000	Fallopian tube	Fallopian tube	138	4.069096e-08	1
HPA	HPA:0291161	Liver; cholangiocytes[≥Low]	Liver; cholangiocytes[≥Low]	94	5.026394e-08	1
HPA	HPA:0170000	Endometrium 2	Endometrium 2	132	5.503431e-08	1
HPA	HPA:0630000	Cervix	Cervix	132	5.987027e-08	1
HPA	HPA:0471471	Skin 2; lymphocytes[≥Low]	Skin 2; lymphocytes[≥Low]	36	6.290365e-08	1
HPA	HPA:0470201	Skin 2; endothelial cells[≥Low]	Skin 2; endothelial cells[≥Low]	38	7.058399e-08	1
HPA	HPA:0020051	Adrenal gland; glandular cells[≥Low]	Adrenal gland; glandular cells[≥Low]	137	7.328367e-08	1
HPA	HPA:0471441	Skin 2; fibrohistiocytic cells[≥Low]	Skin 2; fibrohistiocytic cells[≥Low]	41	8.073176e-08	1
HPA	HPA:0020000	Adrenal gland	Adrenal gland	137	8.087226e-08	1
HPA	HPA:0030000	Appendix	Appendix	141	9.235468e-08	1
HPA	HPA:0060000	Bronchus	Bronchus	137	1.026571e-07	1
HPA	HPA:0160000	Endometrium 1	Endometrium 1	133	1.048495e-07	1
HPA	HPA:0050052	Breast; glandular cells[≥Medium]	Breast; glandular cells[≥Medium]	109	1.583467e-07	1
HPA	HPA:0471442	Skin 2; fibrohistiocytic cells[≥Medium]	Skin 2; fibrohistiocytic cells[≥Medium]	36	1.796408e-07	1
HPA	HPA:0530722	Spleen; cells in white pulp[≥Medium]	Spleen; cells in white pulp[≥Medium]	73	1.911535e-07	1
HPA	HPA:0250000	Hippocampus	Hippocampus	130	1.951811e-07	1
HPA	HPA:0250131	Hippocampus; neuronal cells[≥Low]	Hippocampus; neuronal cells[≥Low]	123	1.957836e-07	1
HPA	HPA:0470202	Skin 2; endothelial cells[≥Medium]	Skin 2; endothelial cells[≥Medium]	31	2.047774e-07	1
HPA	HPA:0461461	Skin 1; langerhans cells[≥Low]	Skin 1; langerhans cells[≥Low]	33	2.124881e-07	1
HPA	HPA:0600000	Tonsil	Tonsil	140	2.162733e-07	1
HPA	HPA:0461391	Skin 1; cells in basal layer[≥Low]	Skin 1; cells in basal layer[≥Low]	37	2.186780e-07	1
HPA	HPA:0380000	Placenta	Placenta	137	3.065819e-07	1
HPA	HPA:0310432	Lymph node; germinal center cells[≥Medium]	Lymph node; germinal center cells[≥Medium]	82	3.190207e-07	1
HPA	HPA:0180051	Epididymis; glandular cells[≥Low]	Epididymis; glandular cells[≥Low]	135	3.706434e-07	1
HPA	HPA:0180000	Epididymis	Epididymis	135	3.706434e-07	1
HPA	HPA:0420052	Salivary gland; glandular cells[≥Medium]	Salivary gland; glandular cells[≥Medium]	105	3.814345e-07	1
HPA	HPA:0090191	Cerebellum; cells in molecular layer[≥Low]	Cerebellum; cells in molecular layer[≥Low]	99	4.600000e-07	1
HPA	HPA:0530711	Spleen; cells in red pulp[≥Low]	Spleen; cells in red pulp[≥Low]	111	5.050018e-07	1
HPA	HPA:0210052	Fallopian tube; glandular cells[≥Medium]	Fallopian tube; glandular cells[≥Medium]	102	5.136778e-07	1
HPA	HPA:0471411	Skin 2; cells in spinous layer[≥Low]	Skin 2; cells in spinous layer[≥Low]	36	6.050207e-07	1
HPA	HPA:0600221	Tonsil; squamous epithelial cells[≥Low]	Tonsil; squamous epithelial cells[≥Low]	127	6.059950e-07	1
HPA	HPA:0080131	Caudate; neuronal cells[≥Low]	Caudate; neuronal cells[≥Low]	121	7.812859e-07	1
HPA	HPA:0100121	Cerebral cortex; glial cells[≥Low]	Cerebral cortex; glial cells[≥Low]	105	7.941600e-07	1
HPA	HPA:0350472	Pancreas; exocrine glandular cells[≥Medium]	Pancreas; exocrine glandular cells[≥Medium]	110	8.631367e-07	1
HPA	HPA:0160052	Endometrium 1; glandular cells[≥Medium]	Endometrium 1; glandular cells[≥Medium]	108	8.730402e-07	1
HPA	HPA:0350471	Pancreas; exocrine glandular cells[≥Low]	Pancreas; exocrine glandular cells[≥Low]	130	8.890359e-07	1
HPA	HPA:0100000	Cerebral cortex	Cerebral cortex	142	9.357586e-07	1
HPA	HPA:0350000	Pancreas	Pancreas	135	9.366898e-07	1
HPA	HPA:0351181	Pancreas; pancreatic endocrine cells[≥Low]	Pancreas; pancreatic endocrine cells[≥Low]	114	1.012807e-06	1
HPA	HPA:0130000	Colon	Colon	144	1.198675e-06	1
HPA	HPA:0080000	Caudate	Caudate	130	1.202673e-06	1
HPA	HPA:0471472	Skin 2; lymphocytes[≥Medium]	Skin 2; lymphocytes[≥Medium]	30	1.259271e-06	1
HPA	HPA:0130241	Colon; peripheral nerve/ganglion[≥Low]	Colon; peripheral nerve/ganglion[≥Low]	106	1.324846e-06	1
HPA	HPA:0310442	Lymph node; non-germinal center cells[≥Medium]	Lymph node; non-germinal center cells[≥Medium]	91	1.491125e-06	1
HPA	HPA:0210051	Fallopian tube; glandular cells[≥Low]	Fallopian tube; glandular cells[≥Low]	115	1.759874e-06	1
HPA	HPA:0250121	Hippocampus; glial cells[≥Low]	Hippocampus; glial cells[≥Low]	93	2.003250e-06	1
HPA	HPA:0430052	Seminal vesicle; glandular cells[≥Medium]	Seminal vesicle; glandular cells[≥Medium]	108	2.529272e-06	1
HPA	HPA:0400000	Rectum	Rectum	140	2.611769e-06	1
HPA	HPA:0170251	Endometrium 2; cells in endometrial stroma[≥Low]	Endometrium 2; cells in endometrial stroma[≥Low]	83	3.288944e-06	1
HPA	HPA:0461441	Skin 1; fibrohistiocytic cells[≥Low]	Skin 1; fibrohistiocytic cells[≥Low]	35	3.352471e-06	1
HPA	HPA:0610832	Urinary bladder; urothelial cells[≥Medium]	Urinary bladder; urothelial cells[≥Medium]	117	3.583687e-06	1
HPA	HPA:0461411	Skin 1; cells in spinous layer[≥Low]	Skin 1; cells in spinous layer[≥Low]	32	3.683647e-06	1
HPA	HPA:0150000	Duodenum	Duodenum	139	3.755671e-06	1
HPA	HPA:0050091	Breast; myoepithelial cells[≥Low]	Breast; myoepithelial cells[≥Low]	113	4.471869e-06	1
HPA	HPA:0420000	Salivary gland	Salivary gland	128	5.068963e-06	1
HPA	HPA:0420051	Salivary gland; glandular cells[≥Low]	Salivary gland; glandular cells[≥Low]	128	5.068963e-06	1
HPA	HPA:0500000	Soft tissue 1	Soft tissue 1	109	5.149261e-06	1
HPA	HPA:0461442	Skin 1; fibrohistiocytic cells[≥Medium]	Skin 1; fibrohistiocytic cells[≥Medium]	30	7.421946e-06	1
HPA	HPA:0320000	Nasopharynx	Nasopharynx	131	7.763068e-06	1
HPA	HPA:0610831	Urinary bladder; urothelial cells[≥Low]	Urinary bladder; urothelial cells[≥Low]	132	8.672829e-06	1
HPA	HPA:0610000	Urinary bladder	Urinary bladder	132	8.672829e-06	1
HPA	HPA:0301373	Lung; alveolar cells type II[High]	Lung; alveolar cells type II[High]	29	8.706288e-06	1
HPA	HPA:0040082	Bone marrow; hematopoietic cells[≥Medium]	Bone marrow; hematopoietic cells[≥Medium]	93	9.600399e-06	1
HPA	HPA:0510000	Soft tissue 2	Soft tissue 2	106	1.156147e-05	1
HPA	HPA:0380511	Placenta; decidual cells[≥Low]	Placenta; decidual cells[≥Low]	101	1.182876e-05	1
HPA	HPA:0460202	Skin 1; endothelial cells[≥Medium]	Skin 1; endothelial cells[≥Medium]	27	1.228026e-05	1
HPA	HPA:0460000	Skin 1	Skin 1	131	1.292635e-05	1
HPA	HPA:0470181	Skin 2; cells in granular layer[≥Low]	Skin 2; cells in granular layer[≥Low]	30	1.443062e-05	1
HPA	HPA:0060101	Bronchus; respiratory epithelial cells[≥Low]	Bronchus; respiratory epithelial cells[≥Low]	115	1.446110e-05	1
HPA	HPA:0020052	Adrenal gland; glandular cells[≥Medium]	Adrenal gland; glandular cells[≥Medium]	116	1.964738e-05	1
HPA	HPA:0291162	Liver; cholangiocytes[≥Medium]	Liver; cholangiocytes[≥Medium]	55	2.126339e-05	1
HPA	HPA:0190221	Esophagus; squamous epithelial cells[≥Low]	Esophagus; squamous epithelial cells[≥Low]	124	2.213610e-05	1
HPA	HPA:0190000	Esophagus	Esophagus	124	2.213610e-05	1
HPA	HPA:0300202	Lung; endothelial cells[≥Medium]	Lung; endothelial cells[≥Medium]	28	2.306071e-05	1
HPA	HPA:0220051	Gallbladder; glandular cells[≥Low]	Gallbladder; glandular cells[≥Low]	135	2.364994e-05	1
HPA	HPA:0220000	Gallbladder	Gallbladder	135	2.364994e-05	1
HPA	HPA:0510651	Soft tissue 2; fibroblasts[≥Low]	Soft tissue 2; fibroblasts[≥Low]	90	2.425816e-05	1
HPA	HPA:0590000	Thyroid gland	Thyroid gland	129	2.694648e-05	1
HPA	HPA:0590051	Thyroid gland; glandular cells[≥Low]	Thyroid gland; glandular cells[≥Low]	129	2.694648e-05	1
HPA	HPA:0060102	Bronchus; respiratory epithelial cells[≥Medium]	Bronchus; respiratory epithelial cells[≥Medium]	101	2.875531e-05	1
HPA	HPA:0010011	Adipose tissue; adipocytes[≥Low]	Adipose tissue; adipocytes[≥Low]	87	3.027624e-05	1
HPA	HPA:0010000	Adipose tissue	Adipose tissue	87	3.027624e-05	1
HPA	HPA:0471462	Skin 2; langerhans cells[≥Medium]	Skin 2; langerhans cells[≥Medium]	28	3.173188e-05	1
HPA	HPA:0250132	Hippocampus; neuronal cells[≥Medium]	Hippocampus; neuronal cells[≥Medium]	91	3.654310e-05	1
HPA	HPA:0630221	Cervix; squamous epithelial cells[≥Low]	Cervix; squamous epithelial cells[≥Low]	108	3.915165e-05	1
HPA	HPA:0550000	Stomach 2	Stomach 2	134	3.945686e-05	1
HPA	HPA:0550051	Stomach 2; glandular cells[≥Low]	Stomach 2; glandular cells[≥Low]	134	3.945686e-05	1
HPA	HPA:0461471	Skin 1; lymphocytes[≥Low]	Skin 1; lymphocytes[≥Low]	29	4.203846e-05	1
HPA	HPA:0570813	Testis; spermatogonia cells[High]	Testis; spermatogonia cells[High]	45	4.389625e-05	1
HPA	HPA:0270351	Kidney; cells in glomeruli[≥Low]	Kidney; cells in glomeruli[≥Low]	104	4.538163e-05	1
HPA	HPA:0510701	Soft tissue 2; peripheral nerve[≥Low]	Soft tissue 2; peripheral nerve[≥Low]	75	4.840268e-05	1
HPA	HPA:0320102	Nasopharynx; respiratory epithelial cells[≥Medium]	Nasopharynx; respiratory epithelial cells[≥Medium]	98	5.293288e-05	1
HPA	HPA:0470672	Skin 2; melanocytes[≥Medium]	Skin 2; melanocytes[≥Medium]	27	5.830320e-05	1
HPA	HPA:0600442	Tonsil; non-germinal center cells[≥Medium]	Tonsil; non-germinal center cells[≥Medium]	90	6.384976e-05	1
HPA	HPA:0190222	Esophagus; squamous epithelial cells[≥Medium]	Esophagus; squamous epithelial cells[≥Medium]	102	6.830936e-05	1
HPA	HPA:0550052	Stomach 2; glandular cells[≥Medium]	Stomach 2; glandular cells[≥Medium]	118	6.942343e-05	1
HPA	HPA:0100132	Cerebral cortex; neuronal cells[≥Medium]	Cerebral cortex; neuronal cells[≥Medium]	101	7.299034e-05	1
HPA	HPA:0100201	Cerebral cortex; endothelial cells[≥Low]	Cerebral cortex; endothelial cells[≥Low]	96	7.485448e-05	1
HPA	HPA:0360000	Parathyroid gland	Parathyroid gland	113	7.562550e-05	1
HPA	HPA:0360051	Parathyroid gland; glandular cells[≥Low]	Parathyroid gland; glandular cells[≥Low]	113	7.562550e-05	1
HPA	HPA:0100131	Cerebral cortex; neuronal cells[≥Low]	Cerebral cortex; neuronal cells[≥Low]	123	8.527857e-05	1
HPA	HPA:0130201	Colon; endothelial cells[≥Low]	Colon; endothelial cells[≥Low]	110	8.864961e-05	1
HPA	HPA:0471473	Skin 2; lymphocytes[High]	Skin 2; lymphocytes[High]	22	9.420297e-05	1
HPA	HPA:0030071	Appendix; lymphoid tissue[≥Low]	Appendix; lymphoid tissue[≥Low]	97	1.075604e-04	1
HPA	HPA:0390052	Prostate; glandular cells[≥Medium]	Prostate; glandular cells[≥Medium]	98	1.099399e-04	1
HPA	HPA:0430000	Seminal vesicle	Seminal vesicle	124	1.252532e-04	1
HPA	HPA:0430051	Seminal vesicle; glandular cells[≥Low]	Seminal vesicle; glandular cells[≥Low]	124	1.252532e-04	1
HPA	HPA:0040000	Bone marrow	Bone marrow	120	1.296007e-04	1
HPA	HPA:0040081	Bone marrow; hematopoietic cells[≥Low]	Bone marrow; hematopoietic cells[≥Low]	120	1.296007e-04	1
HPA	HPA:0300412	Lung; macrophages[≥Medium]	Lung; macrophages[≥Medium]	99	1.318034e-04	1
HPA	HPA:0570000	Testis	Testis	147	1.325648e-04	1
HPA	HPA:0460181	Skin 1; cells in granular layer[≥Low]	Skin 1; cells in granular layer[≥Low]	28	1.380101e-04	1
HPA	HPA:0300201	Lung; endothelial cells[≥Low]	Lung; endothelial cells[≥Low]	30	1.398589e-04	1
HPA	HPA:0471392	Skin 2; cells in basal layer[≥Medium]	Skin 2; cells in basal layer[≥Medium]	29	1.402584e-04	1
HPA	HPA:0390051	Prostate; glandular cells[≥Low]	Prostate; glandular cells[≥Low]	122	1.471634e-04	1
HPA	HPA:0390000	Prostate	Prostate	122	1.471634e-04	1
HPA	HPA:0220052	Gallbladder; glandular cells[≥Medium]	Gallbladder; glandular cells[≥Medium]	121	1.867360e-04	1
HPA	HPA:0300411	Lung; macrophages[≥Low]	Lung; macrophages[≥Low]	123	1.911602e-04	1
HPA	HPA:0470671	Skin 2; melanocytes[≥Low]	Skin 2; melanocytes[≥Low]	28	1.989193e-04	1
HPA	HPA:0290000	Liver	Liver	117	1.996160e-04	1
HPA	HPA:0590052	Thyroid gland; glandular cells[≥Medium]	Thyroid gland; glandular cells[≥Medium]	108	2.075088e-04	1
HPA	HPA:0080121	Caudate; glial cells[≥Low]	Caudate; glial cells[≥Low]	94	2.091848e-04	1
HPA	HPA:0600222	Tonsil; squamous epithelial cells[≥Medium]	Tonsil; squamous epithelial cells[≥Medium]	99	2.320824e-04	1
HPA	HPA:0270000	Kidney	Kidney	139	2.370865e-04	1
HPA	HPA:0320101	Nasopharynx; respiratory epithelial cells[≥Low]	Nasopharynx; respiratory epithelial cells[≥Low]	110	2.458591e-04	1
HPA	HPA:0130202	Colon; endothelial cells[≥Medium]	Colon; endothelial cells[≥Medium]	81	2.646166e-04	1
HPA	HPA:0570801	Testis; sertoli cells[≥Low]	Testis; sertoli cells[≥Low]	62	3.331277e-04	1
HPA	HPA:0540052	Stomach 1; glandular cells[≥Medium]	Stomach 1; glandular cells[≥Medium]	117	3.661447e-04	1
HPA	HPA:0461462	Skin 1; langerhans cells[≥Medium]	Skin 1; langerhans cells[≥Medium]	24	4.000974e-04	1
HPA	HPA:0300000	Lung	Lung	129	4.659252e-04	1
HPA	HPA:0470000	Skin 2	Skin 2	125	4.877175e-04	1
HPA	HPA:0630051	Cervix; glandular cells[≥Low]	Cervix; glandular cells[≥Low]	108	5.767748e-04	1
HPA	HPA:0620000	Vagina	Vagina	112	5.907088e-04	1
HPA	HPA:0620221	Vagina; squamous epithelial cells[≥Low]	Vagina; squamous epithelial cells[≥Low]	112	5.907088e-04	1
HPA	HPA:0380512	Placenta; decidual cells[≥Medium]	Placenta; decidual cells[≥Medium]	78	6.093915e-04	1
HPA	HPA:0540051	Stomach 1; glandular cells[≥Low]	Stomach 1; glandular cells[≥Low]	132	6.112697e-04	1
HPA	HPA:0540000	Stomach 1	Stomach 1	132	6.112697e-04	1
HPA	HPA:0530712	Spleen; cells in red pulp[≥Medium]	Spleen; cells in red pulp[≥Medium]	71	7.074182e-04	1
HPA	HPA:0160053	Endometrium 1; glandular cells[High]	Endometrium 1; glandular cells[High]	42	8.942350e-04	1
HPA	HPA:0480000	Small intestine	Small intestine	134	8.965865e-04	1
HPA	HPA:0380521	Placenta; trophoblastic cells[≥Low]	Placenta; trophoblastic cells[≥Low]	116	9.431723e-04	1
HPA	HPA:0100211	Cerebral cortex; neuropil[≥Low]	Cerebral cortex; neuropil[≥Low]	98	9.784169e-04	1
HPA	HPA:0351182	Pancreas; pancreatic endocrine cells[≥Medium]	Pancreas; pancreatic endocrine cells[≥Medium]	78	9.806741e-04	1
HPA	HPA:0030072	Appendix; lymphoid tissue[≥Medium]	Appendix; lymphoid tissue[≥Medium]	68	1.047584e-03	1
HPA	HPA:0500651	Soft tissue 1; fibroblasts[≥Low]	Soft tissue 1; fibroblasts[≥Low]	87	1.059931e-03	1
HPA	HPA:0490000	Smooth muscle	Smooth muscle	104	1.063313e-03	1
HPA	HPA:0490691	Smooth muscle; smooth muscle cells[≥Low]	Smooth muscle; smooth muscle cells[≥Low]	104	1.063313e-03	1
HPA	HPA:0050092	Breast; myoepithelial cells[≥Medium]	Breast; myoepithelial cells[≥Medium]	80	1.198937e-03	1
HPA	HPA:0461472	Skin 1; lymphocytes[≥Medium]	Skin 1; lymphocytes[≥Medium]	23	1.272396e-03	1
HPA	HPA:0330221	Oral mucosa; squamous epithelial cells[≥Low]	Oral mucosa; squamous epithelial cells[≥Low]	114	1.674695e-03	1
HPA	HPA:0330000	Oral mucosa	Oral mucosa	114	1.674695e-03	1
HPA	HPA:0130051	Colon; glandular cells[≥Low]	Colon; glandular cells[≥Low]	123	1.928712e-03	1
HPA	HPA:0030051	Appendix; glandular cells[≥Low]	Appendix; glandular cells[≥Low]	120	1.940159e-03	1
HPA	HPA:0471412	Skin 2; cells in spinous layer[≥Medium]	Skin 2; cells in spinous layer[≥Medium]	25	2.251117e-03	1
HPA	HPA:0130052	Colon; glandular cells[≥Medium]	Colon; glandular cells[≥Medium]	110	2.474810e-03	1
HPA	HPA:0570802	Testis; sertoli cells[≥Medium]	Testis; sertoli cells[≥Medium]	48	2.555945e-03	1
HPA	HPA:0210053	Fallopian tube; glandular cells[High]	Fallopian tube; glandular cells[High]	44	3.151542e-03	1
HPA	HPA:0570731	Testis; Leydig cells[≥Low]	Testis; Leydig cells[≥Low]	124	3.851362e-03	1
HPA	HPA:0130242	Colon; peripheral nerve/ganglion[≥Medium]	Colon; peripheral nerve/ganglion[≥Medium]	73	4.332624e-03	1
HPA	HPA:0460671	Skin 1; melanocytes[≥Low]	Skin 1; melanocytes[≥Low]	100	4.687883e-03	1
HPA	HPA:0270362	Kidney; cells in tubules[≥Medium]	Kidney; cells in tubules[≥Medium]	107	4.809298e-03	1
HPA	HPA:0080122	Caudate; glial cells[≥Medium]	Caudate; glial cells[≥Medium]	55	4.815898e-03	1
HPA	HPA:0360052	Parathyroid gland; glandular cells[≥Medium]	Parathyroid gland; glandular cells[≥Medium]	87	6.578809e-03	1
HPA	HPA:0461412	Skin 1; cells in spinous layer[≥Medium]	Skin 1; cells in spinous layer[≥Medium]	22	6.623902e-03	1
HPA	HPA:0461392	Skin 1; cells in basal layer[≥Medium]	Skin 1; cells in basal layer[≥Medium]	23	6.889418e-03	1
HPA	HPA:0270352	Kidney; cells in glomeruli[≥Medium]	Kidney; cells in glomeruli[≥Medium]	67	7.149751e-03	1
HPA	HPA:0590053	Thyroid gland; glandular cells[High]	Thyroid gland; glandular cells[High]	47	7.193136e-03	1
HPA	HPA:0030052	Appendix; glandular cells[≥Medium]	Appendix; glandular cells[≥Medium]	102	7.947114e-03	1
HPA	HPA:0460182	Skin 1; cells in granular layer[≥Medium]	Skin 1; cells in granular layer[≥Medium]	21	8.568124e-03	1
HPA	HPA:0570732	Testis; Leydig cells[≥Medium]	Testis; Leydig cells[≥Medium]	100	9.250353e-03	1
HPA	HPA:0510652	Soft tissue 2; fibroblasts[≥Medium]	Soft tissue 2; fibroblasts[≥Medium]	59	9.966549e-03	1
HPA	HPA:0500702	Soft tissue 1; peripheral nerve[≥Medium]	Soft tissue 1; peripheral nerve[≥Medium]	37	1.028465e-02	1
HPA	HPA:0301361	Lung; alveolar cells type I[≥Low]	Lung; alveolar cells type I[≥Low]	32	1.035825e-02	1
HPA	HPA:0470673	Skin 2; melanocytes[High]	Skin 2; melanocytes[High]	16	1.036272e-02	1
HPA	HPA:0570811	Testis; spermatogonia cells[≥Low]	Testis; spermatogonia cells[≥Low]	66	1.098451e-02	1
HPA	HPA:0610833	Urinary bladder; urothelial cells[High]	Urinary bladder; urothelial cells[High]	49	1.247251e-02	1
HPA	HPA:0150051	Duodenum; glandular cells[≥Low]	Duodenum; glandular cells[≥Low]	122	1.283105e-02	1
HPA	HPA:0380513	Placenta; decidual cells[High]	Placenta; decidual cells[High]	34	1.311548e-02	1
HPA	HPA:0380522	Placenta; trophoblastic cells[≥Medium]	Placenta; trophoblastic cells[≥Medium]	95	1.351312e-02	1
HPA	HPA:0330222	Oral mucosa; squamous epithelial cells[≥Medium]	Oral mucosa; squamous epithelial cells[≥Medium]	85	1.583614e-02	1
HPA	HPA:0150052	Duodenum; glandular cells[≥Medium]	Duodenum; glandular cells[≥Medium]	109	1.635687e-02	1
HPA	HPA:0400052	Rectum; glandular cells[≥Medium]	Rectum; glandular cells[≥Medium]	109	1.635687e-02	1
HPA	HPA:0250122	Hippocampus; glial cells[≥Medium]	Hippocampus; glial cells[≥Medium]	48	1.754664e-02	1
HPA	HPA:0500701	Soft tissue 1; peripheral nerve[≥Low]	Soft tissue 1; peripheral nerve[≥Low]	61	1.818754e-02	1
HPA	HPA:0340451	Ovary; follicle cells[≥Low]	Ovary; follicle cells[≥Low]	69	1.877365e-02	1
HPA	HPA:0500111	Soft tissue 1; chondrocytes[≥Low]	Soft tissue 1; chondrocytes[≥Low]	51	1.880996e-02	1
HPA	HPA:0091001	Cerebellum; molecular layer cells - cytoplasm/membrane[≥Low]	Cerebellum; molecular layer cells - cytoplasm/membrane[≥Low]	15	2.112517e-02	1
HPA	HPA:0570812	Testis; spermatogonia cells[≥Medium]	Testis; spermatogonia cells[≥Medium]	57	2.370434e-02	1
HPA	HPA:0471443	Skin 2; fibrohistiocytic cells[High]	Skin 2; fibrohistiocytic cells[High]	18	2.422966e-02	1
HPA	HPA:0090181	Cerebellum; cells in granular layer[≥Low]	Cerebellum; cells in granular layer[≥Low]	87	2.460372e-02	1
HPA	HPA:0091002	Cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium]	Cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium]	14	2.495609e-02	1
HPA	HPA:0301362	Lung; alveolar cells type I[≥Medium]	Lung; alveolar cells type I[≥Medium]	27	2.508005e-02	1
HPA	HPA:0470182	Skin 2; cells in granular layer[≥Medium]	Skin 2; cells in granular layer[≥Medium]	20	2.983226e-02	1
HPA	HPA:0050011	Breast; adipocytes[≥Low]	Breast; adipocytes[≥Low]	60	3.060894e-02	1
HPA	HPA:0160252	Endometrium 1; cells in endometrial stroma[≥Medium]	Endometrium 1; cells in endometrial stroma[≥Medium]	51	3.316666e-02	1
HPA	HPA:0400652	Rectum; fibroblasts[≥Medium]	Rectum; fibroblasts[≥Medium]	8	3.615423e-02	1
HPA	HPA:0630052	Cervix; glandular cells[≥Medium]	Cervix; glandular cells[≥Medium]	79	3.677944e-02	1
HPA	HPA:0400051	Rectum; glandular cells[≥Low]	Rectum; glandular cells[≥Low]	120	3.812849e-02	1
HPA	HPA:0620222	Vagina; squamous epithelial cells[≥Medium]	Vagina; squamous epithelial cells[≥Medium]	79	4.075549e-02	1
HPA	HPA:0220053	Gallbladder; glandular cells[High]	Gallbladder; glandular cells[High]	61	4.132523e-02	1
HPA	HPA:0470203	Skin 2; endothelial cells[High]	Skin 2; endothelial cells[High]	14	4.287077e-02	1
HPA	HPA:0600433	Tonsil; germinal center cells[High]	Tonsil; germinal center cells[High]	33	4.396232e-02	1
HPA	HPA:0500113	Soft tissue 1; chondrocytes[High]	Soft tissue 1; chondrocytes[High]	14	4.428987e-02	1

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP2359	Parkin ubiquitin proteasomal system pathway	Parkin ubiquitin proteasomal system pathway	17	1.684157e-13	1
WP	WP:WP5426	HDAC6 interactions in the central nervous system	HDAC6 interactions in the central nervous system	20	1.876849e-13	1
WP	WP:WP481	Insulin signaling	Insulin signaling	17	1.637162e-07	1
WP	WP:WP5124	Alzheimer 39 s disease	Alzheimer 39 s disease	21	2.443105e-07	1
WP	WP:WP2059	Alzheimer 39 s disease and miRNA effects	Alzheimer 39 s disease and miRNA effects	21	3.458929e-07	1
WP	WP:WP4566	Translation inhibitors in chronically activated PDGFRA cells	Translation inhibitors in chronically activated PDGFRA cells	10	5.235037e-07	1
WP	WP:WP4018	Clear cell renal cell carcinoma pathways	Clear cell renal cell carcinoma pathways	12	2.316037e-06	1
WP	WP:WP3965	Lipid metabolism pathway	Lipid metabolism pathway	8	2.877460e-06	1
WP	WP:WP382	MAPK signaling	MAPK signaling	19	3.179989e-06	1
WP	WP:WP231	TNF alpha signaling	TNF alpha signaling	12	3.951910e-06	1
WP	WP:WP2795	Cardiac hypertrophic response	Cardiac hypertrophic response	9	3.939486e-05	1
WP	WP:WP4290	Metabolic reprogramming in colon cancer	Metabolic reprogramming in colon cancer	8	6.614152e-05	1
WP	WP:WP2380	Brain derived neurotrophic factor BDNF signaling	Brain derived neurotrophic factor BDNF signaling	13	6.932535e-05	1
WP	WP:WP3915	Angiopoietin like protein 8 regulatory pathway	Angiopoietin like protein 8 regulatory pathway	12	3.188983e-04	1
WP	WP:WP195	IL1 signaling	IL1 signaling	8	4.942226e-04	1
WP	WP:WP3879	4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression	4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression	6	5.040207e-04	1
WP	WP:WP4949	16p11 2 proximal deletion syndrome	16p11 2 proximal deletion syndrome	9	7.781312e-04	1
WP	WP:WP183	Proteasome degradation	Proteasome degradation	8	1.438599e-03	1
WP	WP:WP2261	Glioblastoma signaling	Glioblastoma signaling	9	1.473052e-03	1
WP	WP:WP534	Glycolysis and gluconeogenesis	Glycolysis and gluconeogenesis	7	1.555125e-03	1
WP	WP:WP437	EGF EGFR signaling	EGF EGFR signaling	12	2.093564e-03	1
WP	WP:WP2018	RANKL RANK signaling	RANKL RANK signaling	7	3.197468e-03	1
WP	WP:WP4539	Synaptic signaling associated with autism spectrum disorder	Synaptic signaling associated with autism spectrum disorder	7	3.197468e-03	1
WP	WP:WP5531	AKT signaling and ARTD family members	AKT signaling and ARTD family members	6	3.390958e-03	1
WP	WP:WP5441	Artemisinin inhibition of uveal melanoma	Artemisinin inhibition of uveal melanoma	3	3.623271e-03	1
WP	WP:WP5437	GNAQ pathways in port wine stain	GNAQ pathways in port wine stain	5	3.840081e-03	1
WP	WP:WP3888	VEGFA VEGFR2 signaling	VEGFA VEGFR2 signaling	20	4.445939e-03	1
WP	WP:WP5215	Targeted agents in triple negative breast cancer	Targeted agents in triple negative breast cancer	6	6.596321e-03	1
WP	WP:WP3932	Focal adhesion PI3K Akt mTOR signaling	Focal adhesion PI3K Akt mTOR signaling	16	6.775384e-03	1
WP	WP:WP4172	PI3K Akt signaling	PI3K Akt signaling	17	6.813892e-03	1
WP	WP:WP2035	Follicle stimulating hormone FSH signaling	Follicle stimulating hormone FSH signaling	5	7.710285e-03	1
WP	WP:WP4223	Ras signaling	Ras signaling	12	9.139955e-03	1
WP	WP:WP4628	Aerobic glycolysis augmented	Aerobic glycolysis augmented	4	9.350755e-03	1
WP	WP:WP1544	MicroRNAs in cardiomyocyte hypertrophy	MicroRNAs in cardiomyocyte hypertrophy	9	1.018804e-02	1
WP	WP:WP5220	Metabolic reprogramming in pancreatic cancer	Metabolic reprogramming in pancreatic cancer	6	1.187874e-02	1
WP	WP:WP4806	EGFR tyrosine kinase inhibitor resistance	EGFR tyrosine kinase inhibitor resistance	8	1.370992e-02	1
WP	WP:WP3873	RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis	RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis	4	1.740240e-02	1
WP	WP:WP5094	Orexin receptor pathway	Orexin receptor pathway	8	1.913442e-02	1
WP	WP:WP673	ErbB signaling	ErbB signaling	8	2.073781e-02	1
WP	WP:WP35	G protein signaling	G protein signaling	8	2.073781e-02	1
WP	WP:WP1403	AMP activated protein kinase signaling	AMP activated protein kinase signaling	7	2.208979e-02	1
WP	WP:WP5355	Metabolic epileptic disorders	Metabolic epileptic disorders	8	2.427962e-02	1
WP	WP:WP5293	Acute myeloid leukemia	Acute myeloid leukemia	7	2.429234e-02	1
WP	WP:WP2038	Microtubule cytoskeleton regulation	Microtubule cytoskeleton regulation	6	2.563940e-02	1
WP	WP:WP1982	Sterol regulatory element binding proteins SREBP signaling	Sterol regulatory element binding proteins SREBP signaling	7	2.667022e-02	1
WP	WP:WP2034	Leptin signaling	Leptin signaling	7	3.199373e-02	1
WP	WP:WP3844	PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer	PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer	5	3.288328e-02	1
WP	WP:WP4549	Fragile X syndrome	Fragile X syndrome	9	3.312654e-02	1
WP	WP:WP5490	Inhibition of GNAQ regulated signaling in uveal melanoma	Inhibition of GNAQ regulated signaling in uveal melanoma	5	3.824987e-02	1
WP	WP:WP5344	Cardiomyocyte signaling converging on titin	Cardiomyocyte signaling converging on titin	5	3.824987e-02	1
WP	WP:WP244	Alpha 6 beta 4 signaling	Alpha 6 beta 4 signaling	5	3.824987e-02	1
WP	WP:WP4540	Hippo signaling regulation	Hippo signaling regulation	8	4.084406e-02	1
WP	WP:WP4674	Head and neck squamous cell carcinoma	Head and neck squamous cell carcinoma	7	4.156527e-02	1
WP	WP:WP5434	Cancer pathways	Cancer pathways	20	4.173838e-02	1
WP	WP:WP69	T cell receptor signaling	T cell receptor signaling	7	4.522603e-02	1

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-168256	Immune System	Immune System	72	9.454558e-12	1
REAC	REAC:R-HSA-1643685	Disease	Disease	64	5.384909e-10	1
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	46	1.825744e-09	1
REAC	REAC:R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	12	1.000815e-08	1
REAC	REAC:R-HSA-1280218	Adaptive Immune System	Adaptive Immune System	38	2.223591e-08	1
REAC	REAC:R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	Formation of tubulin folding intermediates by CCT/TriC	9	2.518223e-08	1
REAC	REAC:R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	10	4.532009e-08	1
REAC	REAC:R-HSA-2262752	Cellular responses to stress	Cellular responses to stress	37	5.547128e-08	1
REAC	REAC:R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	Diseases of signal transduction by growth factor receptors and second messengers	27	8.284225e-08	1
REAC	REAC:R-HSA-8953897	Cellular responses to stimuli	Cellular responses to stimuli	37	9.125100e-08	1
REAC	REAC:R-HSA-3371556	Cellular response to heat stress	Cellular response to heat stress	13	1.350972e-07	1
REAC	REAC:R-HSA-9646399	Aggrephagy	Aggrephagy	10	2.208335e-07	1
REAC	REAC:R-HSA-390466	Chaperonin-mediated protein folding	Chaperonin-mediated protein folding	13	2.408546e-07	1
REAC	REAC:R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	9	2.851021e-07	1
REAC	REAC:R-HSA-1280215	Cytokine Signaling in Immune system	Cytokine Signaling in Immune system	35	5.090094e-07	1
REAC	REAC:R-HSA-391251	Protein folding	Protein folding	13	5.434542e-07	1
REAC	REAC:R-HSA-9006925	Intracellular signaling by second messengers	Intracellular signaling by second messengers	21	5.443099e-07	1
REAC	REAC:R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	The role of GTSE1 in G2/M progression after G2 checkpoint	12	5.513023e-07	1
REAC	REAC:R-HSA-9663891	Selective autophagy	Selective autophagy	12	6.405815e-07	1
REAC	REAC:R-HSA-390450	Folding of actin by CCT/TriC	Folding of actin by CCT/TriC	6	7.536722e-07	1
REAC	REAC:R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	Regulation of mRNA stability by proteins that bind AU-rich elements	12	1.508955e-06	1
REAC	REAC:R-HSA-5358351	Signaling by Hedgehog	Signaling by Hedgehog	15	1.611856e-06	1
REAC	REAC:R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	Prefoldin mediated transfer of substrate to CCT/TriC	8	1.760514e-06	1
REAC	REAC:R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	AUF1 (hnRNP D0) binds and destabilizes mRNA	10	1.881742e-06	1
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	36	2.715774e-06	1
REAC	REAC:R-HSA-5357801	Programmed Cell Death	Programmed Cell Death	17	3.439144e-06	1
REAC	REAC:R-HSA-5610787	Hedgehog 'off' state	Hedgehog 'off' state	13	3.669198e-06	1
REAC	REAC:R-HSA-392499	Metabolism of proteins	Metabolism of proteins	60	5.973647e-06	1
REAC	REAC:R-HSA-8878166	Transcriptional regulation by RUNX2	Transcriptional regulation by RUNX2	13	6.247785e-06	1
REAC	REAC:R-HSA-69275	G2/M Transition	G2/M Transition	16	9.916711e-06	1
REAC	REAC:R-HSA-1257604	PIP3 activates AKT signaling	PIP3 activates AKT signaling	18	1.012175e-05	1
REAC	REAC:R-HSA-3371568	Attenuation phase	Attenuation phase	6	1.027305e-05	1
REAC	REAC:R-HSA-168249	Innate Immune System	Innate Immune System	40	1.143142e-05	1
REAC	REAC:R-HSA-453274	Mitotic G2-G2/M phases	Mitotic G2-G2/M phases	16	1.145442e-05	1
REAC	REAC:R-HSA-9612973	Autophagy	Autophagy	14	1.336523e-05	1
REAC	REAC:R-HSA-3371571	HSF1-dependent transactivation	HSF1-dependent transactivation	7	1.474447e-05	1
REAC	REAC:R-HSA-9675108	Nervous system development	Nervous system development	27	1.715828e-05	1
REAC	REAC:R-HSA-8948751	Regulation of PTEN stability and activity	Regulation of PTEN stability and activity	10	2.220611e-05	1
REAC	REAC:R-HSA-422475	Axon guidance	Axon guidance	26	2.750680e-05	1
REAC	REAC:R-HSA-1632852	Macroautophagy	Macroautophagy	13	2.910578e-05	1
REAC	REAC:R-HSA-5621481	C-type lectin receptors (CLRs)	C-type lectin receptors (CLRs)	13	3.473670e-05	1
REAC	REAC:R-HSA-449147	Signaling by Interleukins	Signaling by Interleukins	24	3.621180e-05	1
REAC	REAC:R-HSA-4420097	VEGFA-VEGFR2 Pathway	VEGFA-VEGFR2 Pathway	11	4.529575e-05	1
REAC	REAC:R-HSA-5607764	CLEC7A (Dectin-1) signaling	CLEC7A (Dectin-1) signaling	11	6.287287e-05	1
REAC	REAC:R-HSA-202424	Downstream TCR signaling	Downstream TCR signaling	11	6.994912e-05	1
REAC	REAC:R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	GLI3 is processed to GLI3R by the proteasome	9	7.833301e-05	1
REAC	REAC:R-HSA-5610780	Degradation of GLI1 by the proteasome	Degradation of GLI1 by the proteasome	9	7.833301e-05	1
REAC	REAC:R-HSA-5610783	Degradation of GLI2 by the proteasome	Degradation of GLI2 by the proteasome	9	7.833301e-05	1
REAC	REAC:R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	Downstream signaling events of B Cell Receptor (BCR)	10	9.384106e-05	1
REAC	REAC:R-HSA-9755511	KEAP1-NFE2L2 pathway	KEAP1-NFE2L2 pathway	12	9.801148e-05	1
REAC	REAC:R-HSA-5213460	RIPK1-mediated regulated necrosis	RIPK1-mediated regulated necrosis	7	1.028975e-04	1
REAC	REAC:R-HSA-5675482	Regulation of necroptotic cell death	Regulation of necroptotic cell death	7	1.028975e-04	1
REAC	REAC:R-HSA-194138	Signaling by VEGF	Signaling by VEGF	11	1.292580e-04	1
REAC	REAC:R-HSA-5358346	Hedgehog ligand biogenesis	Hedgehog ligand biogenesis	9	1.592655e-04	1
REAC	REAC:R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	Signaling by Receptor Tyrosine Kinases	24	1.612474e-04	1
REAC	REAC:R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	Fc epsilon receptor (FCERI) signaling	14	1.640979e-04	1
REAC	REAC:R-HSA-3371511	HSF1 activation	HSF1 activation	5	1.962020e-04	1
REAC	REAC:R-HSA-1169091	Activation of NF-kappaB in B cells	Activation of NF-kappaB in B cells	9	2.078442e-04	1
REAC	REAC:R-HSA-389357	CD28 dependent PI3K/Akt signaling	CD28 dependent PI3K/Akt signaling	6	2.319345e-04	1
REAC	REAC:R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	7	2.506730e-04	1
REAC	REAC:R-HSA-6804757	Regulation of TP53 Degradation	Regulation of TP53 Degradation	7	3.074295e-04	1
REAC	REAC:R-HSA-9013418	RHOBTB2 GTPase cycle	RHOBTB2 GTPase cycle	6	3.100626e-04	1
REAC	REAC:R-HSA-9604323	Negative regulation of NOTCH4 signaling	Negative regulation of NOTCH4 signaling	8	3.695971e-04	1
REAC	REAC:R-HSA-6806003	Regulation of TP53 Expression and Degradation	Regulation of TP53 Expression and Degradation	7	3.745934e-04	1
REAC	REAC:R-HSA-9009391	Extra-nuclear estrogen signaling	Extra-nuclear estrogen signaling	9	3.890235e-04	1
REAC	REAC:R-HSA-3858494	Beta-catenin independent WNT signaling	Beta-catenin independent WNT signaling	12	4.616882e-04	1
REAC	REAC:R-HSA-162582	Signal Transduction	Signal Transduction	64	5.078711e-04	1
REAC	REAC:R-HSA-392451	G beta:gamma signalling through PI3Kgamma	G beta:gamma signalling through PI3Kgamma	6	5.311137e-04	1
REAC	REAC:R-HSA-202403	TCR signaling	TCR signaling	11	5.515692e-04	1
REAC	REAC:R-HSA-5362768	Hh mutants are degraded by ERAD	Hh mutants are degraded by ERAD	8	5.709982e-04	1
REAC	REAC:R-HSA-68886	M Phase	M Phase	20	7.253398e-04	1
REAC	REAC:R-HSA-5387390	Hh mutants abrogate ligand secretion	Hh mutants abrogate ligand secretion	8	8.592436e-04	1
REAC	REAC:R-HSA-5218920	VEGFR2 mediated vascular permeability	VEGFR2 mediated vascular permeability	6	8.667468e-04	1
REAC	REAC:R-HSA-8863795	Downregulation of ERBB2 signaling	Downregulation of ERBB2 signaling	6	8.667468e-04	1
REAC	REAC:R-HSA-9013694	Signaling by NOTCH4	Signaling by NOTCH4	9	1.067373e-03	1
REAC	REAC:R-HSA-5678895	Defective CFTR causes cystic fibrosis	Defective CFTR causes cystic fibrosis	8	1.113515e-03	1
REAC	REAC:R-HSA-69202	Cyclin E associated events during G1/S transition	Cyclin E associated events during G1/S transition	9	1.184302e-03	1
REAC	REAC:R-HSA-2467813	Separation of Sister Chromatids	Separation of Sister Chromatids	13	1.448172e-03	1
REAC	REAC:R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	Cyclin A:Cdk2-associated events at S phase entry	9	1.451572e-03	1
REAC	REAC:R-HSA-69278	Cell Cycle, Mitotic	Cell Cycle, Mitotic	23	1.736810e-03	1
REAC	REAC:R-HSA-1227986	Signaling by ERBB2	Signaling by ERBB2	7	1.746248e-03	1
REAC	REAC:R-HSA-9824439	Bacterial Infection Pathways	Bacterial Infection Pathways	8	2.043014e-03	1
REAC	REAC:R-HSA-389356	Co-stimulation by CD28	Co-stimulation by CD28	6	2.055299e-03	1
REAC	REAC:R-HSA-6807070	PTEN Regulation	PTEN Regulation	11	2.186946e-03	1
REAC	REAC:R-HSA-3371453	Regulation of HSF1-mediated heat shock response	Regulation of HSF1-mediated heat shock response	8	2.291851e-03	1
REAC	REAC:R-HSA-388841	Regulation of T cell activation by CD28 family	Regulation of T cell activation by CD28 family	8	2.291851e-03	1
REAC	REAC:R-HSA-9020702	Interleukin-1 signaling	Interleukin-1 signaling	10	2.353100e-03	1
REAC	REAC:R-HSA-5687128	MAPK6/MAPK4 signaling	MAPK6/MAPK4 signaling	9	2.356771e-03	1
REAC	REAC:R-HSA-68882	Mitotic Anaphase	Mitotic Anaphase	14	2.413131e-03	1
REAC	REAC:R-HSA-397795	G-protein beta:gamma signalling	G-protein beta:gamma signalling	6	2.499571e-03	1
REAC	REAC:R-HSA-2555396	Mitotic Metaphase and Anaphase	Mitotic Metaphase and Anaphase	14	2.538490e-03	1
REAC	REAC:R-HSA-1236974	ER-Phagosome pathway	ER-Phagosome pathway	9	2.586623e-03	1
REAC	REAC:R-HSA-5617833	Cilium Assembly	Cilium Assembly	13	2.861960e-03	1
REAC	REAC:R-HSA-163359	Glucagon signaling in metabolic regulation	Glucagon signaling in metabolic regulation	6	3.018773e-03	1
REAC	REAC:R-HSA-4086400	PCP/CE pathway	PCP/CE pathway	9	3.104473e-03	1
REAC	REAC:R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	Regulation of activated PAK-2p34 by proteasome mediated degradation	7	3.104687e-03	1
REAC	REAC:R-HSA-8939902	Regulation of RUNX2 expression and activity	Regulation of RUNX2 expression and activity	8	3.560092e-03	1
REAC	REAC:R-HSA-446203	Asparagine N-linked glycosylation	Asparagine N-linked glycosylation	16	3.804554e-03	1
REAC	REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	Transcriptional regulation by RUNX3	9	4.046733e-03	1
REAC	REAC:R-HSA-9759194	Nuclear events mediated by NFE2L2	Nuclear events mediated by NFE2L2	9	4.046733e-03	1
REAC	REAC:R-HSA-109581	Apoptosis	Apoptosis	12	4.055026e-03	1
REAC	REAC:R-HSA-180534	Vpu mediated degradation of CD4	Vpu mediated degradation of CD4	7	4.058959e-03	1
REAC	REAC:R-HSA-69610	p53-Independent DNA Damage Response	p53-Independent DNA Damage Response	7	4.058959e-03	1
REAC	REAC:R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	7	4.058959e-03	1
REAC	REAC:R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	p53-Independent G1/S DNA damage checkpoint	7	4.058959e-03	1
REAC	REAC:R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	Ubiquitin-dependent degradation of Cyclin D	7	4.058959e-03	1
REAC	REAC:R-HSA-9762114	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	7	4.058959e-03	1
REAC	REAC:R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	Autodegradation of the E3 ubiquitin ligase COP1	7	4.058959e-03	1
REAC	REAC:R-HSA-9706574	RHOBTB GTPase Cycle	RHOBTB GTPase Cycle	6	4.319704e-03	1
REAC	REAC:R-HSA-169911	Regulation of Apoptosis	Regulation of Apoptosis	7	4.620384e-03	1
REAC	REAC:R-HSA-180585	Vif-mediated degradation of APOBEC3G	Vif-mediated degradation of APOBEC3G	7	4.620384e-03	1
REAC	REAC:R-HSA-9711123	Cellular response to chemical stress	Cellular response to chemical stress	13	4.858938e-03	1
REAC	REAC:R-HSA-446652	Interleukin-1 family signaling	Interleukin-1 family signaling	11	5.195429e-03	1
REAC	REAC:R-HSA-9613829	Chaperone Mediated Autophagy	Chaperone Mediated Autophagy	5	5.803379e-03	1
REAC	REAC:R-HSA-4641257	Degradation of AXIN	Degradation of AXIN	7	5.937290e-03	1
REAC	REAC:R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	SCF-beta-TrCP mediated degradation of Emi1	7	5.937290e-03	1
REAC	REAC:R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	7	5.937290e-03	1
REAC	REAC:R-HSA-8941858	Regulation of RUNX3 expression and activity	Regulation of RUNX3 expression and activity	7	5.937290e-03	1
REAC	REAC:R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TNFR2 non-canonical NF-kB pathway	9	6.160821e-03	1
REAC	REAC:R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	Association of TriC/CCT with target proteins during biosynthesis	6	7.088679e-03	1
REAC	REAC:R-HSA-5619084	ABC transporter disorders	ABC transporter disorders	8	7.203021e-03	1
REAC	REAC:R-HSA-69541	Stabilization of p53	Stabilization of p53	7	7.550589e-03	1
REAC	REAC:R-HSA-4641258	Degradation of DVL	Degradation of DVL	7	7.550589e-03	1
REAC	REAC:R-HSA-5218859	Regulated Necrosis	Regulated Necrosis	7	8.483746e-03	1
REAC	REAC:R-HSA-1236975	Antigen processing-Cross presentation	Antigen processing-Cross presentation	9	9.152543e-03	1
REAC	REAC:R-HSA-5676590	NIK-->noncanonical NF-kB signaling	NIK-->noncanonical NF-kB signaling	7	9.510121e-03	1
REAC	REAC:R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	DDX58/IFIH1-mediated induction of interferon-alpha/beta	8	1.042755e-02	1
REAC	REAC:R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	Dectin-1 mediated noncanonical NF-kB signaling	7	1.063682e-02	1
REAC	REAC:R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	SCF(Skp2)-mediated degradation of p27/p21	7	1.063682e-02	1
REAC	REAC:R-HSA-163685	Integration of energy metabolism	Integration of energy metabolism	9	1.065522e-02	1
REAC	REAC:R-HSA-983705	Signaling by the B Cell Receptor (BCR)	Signaling by the B Cell Receptor (BCR)	11	1.068019e-02	1
REAC	REAC:R-HSA-5339562	Uptake and actions of bacterial toxins	Uptake and actions of bacterial toxins	5	1.130543e-02	1
REAC	REAC:R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	Constitutive Signaling by AKT1 E17K in Cancer	5	1.130543e-02	1
REAC	REAC:R-HSA-2871837	FCERI mediated NF-kB activation	FCERI mediated NF-kB activation	10	1.212653e-02	1
REAC	REAC:R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	6	1.284249e-02	1
REAC	REAC:R-HSA-9660821	ADORA2B mediated anti-inflammatory cytokines production	ADORA2B mediated anti-inflammatory cytokines production	6	1.284249e-02	1
REAC	REAC:R-HSA-901042	Calnexin/calreticulin cycle	Calnexin/calreticulin cycle	5	1.383475e-02	1
REAC	REAC:R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	Vasopressin regulates renal water homeostasis via Aquaporins	6	1.474826e-02	1
REAC	REAC:R-HSA-983169	Class I MHC mediated antigen processing & presentation	Class I MHC mediated antigen processing & presentation	17	1.557252e-02	1
REAC	REAC:R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	Autodegradation of Cdh1 by Cdh1:APC/C	7	1.630212e-02	1
REAC	REAC:R-HSA-4608870	Asymmetric localization of PCP proteins	Asymmetric localization of PCP proteins	7	1.630212e-02	1
REAC	REAC:R-HSA-9634597	GPER1 signaling	GPER1 signaling	6	1.687469e-02	1
REAC	REAC:R-HSA-1640170	Cell Cycle	Cell Cycle	24	1.799787e-02	1
REAC	REAC:R-HSA-5683057	MAPK family signaling cascades	MAPK family signaling cascades	15	1.895191e-02	1
REAC	REAC:R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	p53-Dependent G1/S DNA damage checkpoint	7	1.994943e-02	1
REAC	REAC:R-HSA-69563	p53-Dependent G1 DNA Damage Response	p53-Dependent G1 DNA Damage Response	7	1.994943e-02	1
REAC	REAC:R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	7	1.994943e-02	1
REAC	REAC:R-HSA-5357905	Regulation of TNFR1 signaling	Regulation of TNFR1 signaling	6	2.186435e-02	1
REAC	REAC:R-HSA-5658442	Regulation of RAS by GAPs	Regulation of RAS by GAPs	7	2.200948e-02	1
REAC	REAC:R-HSA-2219528	PI3K/AKT Signaling in Cancer	PI3K/AKT Signaling in Cancer	8	2.227943e-02	1
REAC	REAC:R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	Antiviral mechanism by IFN-stimulated genes	10	2.365044e-02	1
REAC	REAC:R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	APC/C:Cdc20 mediated degradation of Securin	7	2.424071e-02	1
REAC	REAC:R-HSA-69615	G1/S DNA Damage Checkpoints	G1/S DNA Damage Checkpoints	7	2.424071e-02	1
REAC	REAC:R-HSA-5336415	Uptake and function of diphtheria toxin	Uptake and function of diphtheria toxin	3	2.606790e-02	1
REAC	REAC:R-HSA-437239	Recycling pathway of L1	Recycling pathway of L1	6	2.797059e-02	1
REAC	REAC:R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	Recruitment of NuMA to mitotic centrosomes	8	2.813355e-02	1
REAC	REAC:R-HSA-8939211	ESR-mediated signaling	ESR-mediated signaling	12	2.962450e-02	1
REAC	REAC:R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	Cross-presentation of soluble exogenous antigens (endosomes)	6	3.149637e-02	1
REAC	REAC:R-HSA-68949	Orc1 removal from chromatin	Orc1 removal from chromatin	7	3.207103e-02	1
REAC	REAC:R-HSA-1852241	Organelle biogenesis and maintenance	Organelle biogenesis and maintenance	14	3.668771e-02	1
REAC	REAC:R-HSA-9694516	SARS-CoV-2 Infection	SARS-CoV-2 Infection	14	3.805889e-02	1
REAC	REAC:R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	7	3.835579e-02	1
REAC	REAC:R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	CDK-mediated phosphorylation and removal of Cdc6	7	3.835579e-02	1
REAC	REAC:R-HSA-5689880	Ub-specific processing proteases	Ub-specific processing proteases	12	3.859439e-02	1
REAC	REAC:R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	Signaling by Ligand-Responsive EGFR Variants in Cancer	4	3.921192e-02	1
REAC	REAC:R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	4	3.921192e-02	1
REAC	REAC:R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	Regulation of ornithine decarboxylase (ODC)	6	3.960965e-02	1
REAC	REAC:R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	7	4.185516e-02	1
REAC	REAC:R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	7	4.185516e-02	1
REAC	REAC:R-HSA-76002	Platelet activation, signaling and aggregation	Platelet activation, signaling and aggregation	13	4.342642e-02	1
REAC	REAC:R-HSA-445717	Aquaporin-mediated transport	Aquaporin-mediated transport	6	4.424669e-02	1
REAC	REAC:R-HSA-163765	ChREBP activates metabolic gene expression	ChREBP activates metabolic gene expression	3	4.513458e-02	1
REAC	REAC:R-HSA-9833482	PKR-mediated signaling	PKR-mediated signaling	7	4.561035e-02	1
REAC	REAC:R-HSA-1234174	Cellular response to hypoxia	Cellular response to hypoxia	7	4.561035e-02	1
REAC	REAC:R-HSA-438064	Post NMDA receptor activation events	Post NMDA receptor activation events	7	4.561035e-02	1
REAC	REAC:R-HSA-5688426	Deubiquitination	Deubiquitination	14	4.726290e-02	1
REAC	REAC:R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	COPI-independent Golgi-to-ER retrograde traffic	6	4.930537e-02	1
REAC	REAC:R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	APC/C:Cdc20 mediated degradation of mitotic proteins	7	4.963530e-02	1
REAC	REAC:R-HSA-9758274	Regulation of NF-kappa B signaling	Regulation of NF-kappa B signaling	4	4.985002e-02	1

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-615-3p	hsa-mir-615-3p	hsa-mir-615-3p	40	1.341054e-11	1
MIRNA	MIRNA:hsa-mir-92a-3p	hsa-mir-92a-3p	hsa-mir-92a-3p	45	4.682428e-10	1
MIRNA	MIRNA:hsa-mir-16-5p	hsa-mir-16-5p	hsa-mir-16-5p	48	6.587268e-10	1
MIRNA	MIRNA:hsa-mir-34a-5p	hsa-mir-34a-5p	hsa-mir-34a-5p	24	4.808025e-06	1
MIRNA	MIRNA:hsa-mir-744-5p	hsa-mir-744-5p	hsa-mir-744-5p	19	2.927576e-05	1
MIRNA	MIRNA:hsa-mir-320a	hsa-mir-320a	hsa-mir-320a	42	9.656871e-05	1
MIRNA	MIRNA:hsa-mir-324-3p	hsa-mir-324-3p	hsa-mir-324-3p	39	2.093491e-04	1
MIRNA	MIRNA:hsa-mir-484	hsa-mir-484	hsa-mir-484	45	3.605098e-04	1
MIRNA	MIRNA:hsa-mir-331-3p	hsa-mir-331-3p	hsa-mir-331-3p	33	5.499409e-04	1
MIRNA	MIRNA:hsa-let-7b-5p	hsa-let-7b-5p	hsa-let-7b-5p	31	1.069213e-03	1
MIRNA	MIRNA:hsa-mir-455-3p	hsa-mir-455-3p	hsa-mir-455-3p	34	1.231490e-03	1
MIRNA	MIRNA:hsa-mir-193b-3p	hsa-mir-193b-3p	hsa-mir-193b-3p	24	3.660054e-03	1
MIRNA	MIRNA:hsa-mir-1229-3p	hsa-mir-1229-3p	hsa-mir-1229-3p	11	4.731700e-03	1
MIRNA	MIRNA:hsa-mir-149-5p	hsa-mir-149-5p	hsa-mir-149-5p	15	9.466184e-03	1
MIRNA	MIRNA:hsa-mir-127-5p	hsa-mir-127-5p	hsa-mir-127-5p	23	1.228204e-02	1
MIRNA	MIRNA:hsa-mir-513a-3p	hsa-mir-513a-3p	hsa-mir-513a-3p	38	1.816893e-02	1
MIRNA	MIRNA:hsa-mir-23b-3p	hsa-mir-23b-3p	hsa-mir-23b-3p	13	2.398691e-02	1
MIRNA	MIRNA:hsa-mir-3692	hsa-mir-3692	hsa-mir-3692	30	3.004441e-02	1
MIRNA	MIRNA:hsa-mir-1180-3p	hsa-mir-1180-3p	hsa-mir-1180-3p	6	3.097708e-02	1
MIRNA	MIRNA:hsa-mir-877-3p	hsa-mir-877-3p	hsa-mir-877-3p	18	3.243478e-02	1
MIRNA	MIRNA:hsa-mir-324-5p	hsa-mir-324-5p	hsa-mir-324-5p	22	3.425502e-02	1
MIRNA	MIRNA:hsa-mir-548p	hsa-mir-548p	hsa-mir-548p	36	3.746545e-02	1
MIRNA	MIRNA:hsa-mir-222-3p	hsa-mir-222-3p	hsa-mir-222-3p	14	4.378194e-02	1
MIRNA	MIRNA:hsa-mir-889	hsa-mir-889	hsa-mir-889	26	4.581701e-02	1

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04141	Protein processing in endoplasmic reticulum	Protein processing in endoplasmic reticulum	18	7.814699e-09	1
KEGG	KEGG:05417	Lipid and atherosclerosis	Lipid and atherosclerosis	19	5.890807e-08	1
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	Pathways of neurodegeneration - multiple diseases	27	2.571725e-07	1
KEGG	KEGG:05132	Salmonella infection	Salmonella infection	19	7.490575e-07	1
KEGG	KEGG:05010	Alzheimer disease	Alzheimer disease	23	1.644477e-06	1
KEGG	KEGG:04910	Insulin signaling pathway	Insulin signaling pathway	14	2.064373e-06	1
KEGG	KEGG:05012	Parkinson disease	Parkinson disease	19	2.075090e-06	1
KEGG	KEGG:04612	Antigen processing and presentation	Antigen processing and presentation	10	8.373755e-06	1
KEGG	KEGG:04010	MAPK signaling pathway	MAPK signaling pathway	19	1.583770e-05	1
KEGG	KEGG:05170	Human immunodeficiency virus 1 infection	Human immunodeficiency virus 1 infection	15	7.402639e-05	1
KEGG	KEGG:04931	Insulin resistance	Insulin resistance	11	7.406565e-05	1
KEGG	KEGG:05020	Prion disease	Prion disease	17	8.173829e-05	1
KEGG	KEGG:05163	Human cytomegalovirus infection	Human cytomegalovirus infection	15	1.583353e-04	1
KEGG	KEGG:05017	Spinocerebellar ataxia	Spinocerebellar ataxia	12	1.602197e-04	1
KEGG	KEGG:04213	Longevity regulating pathway - multiple species	Longevity regulating pathway - multiple species	8	3.717097e-04	1
KEGG	KEGG:04066	HIF-1 signaling pathway	HIF-1 signaling pathway	10	6.201938e-04	1
KEGG	KEGG:04915	Estrogen signaling pathway	Estrogen signaling pathway	11	7.226700e-04	1
KEGG	KEGG:05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	PD-L1 expression and PD-1 checkpoint pathway in cancer	9	8.206812e-04	1
KEGG	KEGG:04140	Autophagy - animal	Autophagy - animal	12	8.270047e-04	1
KEGG	KEGG:05169	Epstein-Barr virus infection	Epstein-Barr virus infection	13	1.052991e-03	1
KEGG	KEGG:04722	Neurotrophin signaling pathway	Neurotrophin signaling pathway	10	1.259406e-03	1
KEGG	KEGG:05215	Prostate cancer	Prostate cancer	9	1.661590e-03	1
KEGG	KEGG:04926	Relaxin signaling pathway	Relaxin signaling pathway	10	2.749953e-03	1
KEGG	KEGG:04151	PI3K-Akt signaling pathway	PI3K-Akt signaling pathway	17	3.127863e-03	1
KEGG	KEGG:05145	Toxoplasmosis	Toxoplasmosis	9	3.937483e-03	1
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	Amyotrophic lateral sclerosis	17	4.001831e-03	1
KEGG	KEGG:05167	Kaposi sarcoma-associated herpesvirus infection	Kaposi sarcoma-associated herpesvirus infection	12	4.190514e-03	1
KEGG	KEGG:05418	Fluid shear stress and atherosclerosis	Fluid shear stress and atherosclerosis	10	4.911609e-03	1
KEGG	KEGG:04725	Cholinergic synapse	Cholinergic synapse	9	5.629148e-03	1
KEGG	KEGG:04540	Gap junction	Gap junction	8	5.707715e-03	1
KEGG	KEGG:03050	Proteasome	Proteasome	6	6.468532e-03	1
KEGG	KEGG:05016	Huntington disease	Huntington disease	15	6.712938e-03	1
KEGG	KEGG:05221	Acute myeloid leukemia	Acute myeloid leukemia	7	6.844346e-03	1
KEGG	KEGG:05230	Central carbon metabolism in cancer	Central carbon metabolism in cancer	7	9.076770e-03	1
KEGG	KEGG:05223	Non-small cell lung cancer	Non-small cell lung cancer	7	1.087017e-02	1
KEGG	KEGG:05200	Pathways in cancer	Pathways in cancer	20	1.561201e-02	1
KEGG	KEGG:04062	Chemokine signaling pathway	Chemokine signaling pathway	11	1.583275e-02	1
KEGG	KEGG:04728	Dopaminergic synapse	Dopaminergic synapse	9	1.761508e-02	1
KEGG	KEGG:01521	EGFR tyrosine kinase inhibitor resistance	EGFR tyrosine kinase inhibitor resistance	7	1.954631e-02	1
KEGG	KEGG:04210	Apoptosis	Apoptosis	9	2.210237e-02	1
KEGG	KEGG:04662	B cell receptor signaling pathway	B cell receptor signaling pathway	7	2.285112e-02	1
KEGG	KEGG:04014	Ras signaling pathway	Ras signaling pathway	12	2.589961e-02	1
KEGG	KEGG:04371	Apelin signaling pathway	Apelin signaling pathway	9	2.605862e-02	1
KEGG	KEGG:04012	ErbB signaling pathway	ErbB signaling pathway	7	2.863867e-02	1
KEGG	KEGG:05205	Proteoglycans in cancer	Proteoglycans in cancer	11	3.064376e-02	1
KEGG	KEGG:04668	TNF signaling pathway	TNF signaling pathway	8	3.283755e-02	1
KEGG	KEGG:05207	Chemical carcinogenesis - receptor activation	Chemical carcinogenesis - receptor activation	11	3.920082e-02	1
KEGG	KEGG:04211	Longevity regulating pathway	Longevity regulating pathway	7	4.085405e-02	1
KEGG	KEGG:04660	T cell receptor signaling pathway	T cell receptor signaling pathway	8	4.655761e-02	1
KEGG	KEGG:04935	Growth hormone synthesis, secretion and action	Growth hormone synthesis, secretion and action	8	4.924053e-02	1
KEGG	KEGG:04152	AMPK signaling pathway	AMPK signaling pathway	8	4.924053e-02	1
KEGG	KEGG:05222	Small cell lung cancer	Small cell lung cancer	7	4.997940e-02	1

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:126	CCT complex (chaperonin containing TCP1 complex)	CCT complex (chaperonin containing TCP1 complex)	6	8.519520e-07	1
CORUM	CORUM:2112	CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex	CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex	4	6.012253e-05	1
CORUM	CORUM:5212	Kinase maturation complex 2	Kinase maturation complex 2	5	7.337571e-05	1
CORUM	CORUM:5269	TNF-alpha/NF-kappa B signaling complex 8	TNF-alpha/NF-kappa B signaling complex 8	4	8.688458e-04	1
CORUM	CORUM:5849	HSP90-CDC37-LRRK2 complex	HSP90-CDC37-LRRK2 complex	3	2.572331e-03	1
CORUM	CORUM:5980	LRRK2-CHIP-HSP90 complex	LRRK2-CHIP-HSP90 complex	3	2.572331e-03	1
CORUM	CORUM:5268	TNF-alpha/NF-kappa B signaling complex 7	TNF-alpha/NF-kappa B signaling complex 7	4	3.906442e-03	1
CORUM	CORUM:5199	Kinase maturation complex 1	Kinase maturation complex 1	5	4.910777e-03	1
CORUM	CORUM:6247	BBS-chaperonin complex	BBS-chaperonin complex	4	1.129152e-02	1
CORUM	CORUM:5286	TNF-alpha/NF-kappa B signaling complex 10	TNF-alpha/NF-kappa B signaling complex 10	4	1.129152e-02	1
CORUM	CORUM:32	PA700 complex	PA700 complex	5	1.614836e-02	1
CORUM	CORUM:5234	IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex	IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex	3	2.482980e-02	1
CORUM	CORUM:5285	TNF-alpha/NF-kappa B signaling complex 9	TNF-alpha/NF-kappa B signaling complex 9	3	2.482980e-02	1
CORUM	CORUM:5266	TNF-alpha/NF-kappa B signaling complex 6	TNF-alpha/NF-kappa B signaling complex 6	4	3.636207e-02	1

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M07206	Factor: E2F-1; motif: NGGGCGGGARV	Factor: E2F-1; motif: NGGGCGGGARV	165	0.000013	1
TF	TF:M09894_1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	161	0.000013	1
TF	TF:M00716_1	Factor: ZF5; motif: GSGCGCGR; match class: 1	Factor: ZF5; motif: GSGCGCGR; match class: 1	162	0.000013	1
TF	TF:M01660	Factor: GABP-alpha; motif: CTTCCK	Factor: GABP-alpha; motif: CTTCCK	139	0.000015	1
TF	TF:M03567	Factor: Sp2; motif: NYSGCCCCGCCCCCY	Factor: Sp2; motif: NYSGCCCCGCCCCCY	109	0.000029	1
TF	TF:M11435	Factor: Elk-1; motif: NNCCGGAAGTN	Factor: Elk-1; motif: NNCCGGAAGTN	143	0.000039	1
TF	TF:M13135	Factor: SP4; motif: GGCCCCGCCCCCN	Factor: SP4; motif: GGCCCCGCCCCCN	87	0.000050	1
TF	TF:M12173	Factor: GKLF; motif: NNCCMCRCCCN	Factor: GKLF; motif: NNCCMCRCCCN	129	0.000051	1
TF	TF:M12666	Factor: SP1; motif: GGCCCCGCCCCCN	Factor: SP1; motif: GGCCCCGCCCCCN	117	0.000068	1
TF	TF:M00196	Factor: Sp1; motif: NGGGGGCGGGGYN	Factor: Sp1; motif: NGGGGGCGGGGYN	131	0.000069	1
TF	TF:M12151	Factor: Sp1; motif: NWRGCCMCGCCCMCN	Factor: Sp1; motif: NWRGCCMCGCCCMCN	99	0.000096	1
TF	TF:M00695	Factor: ETF; motif: GVGGMGG	Factor: ETF; motif: GVGGMGG	132	0.000097	1
TF	TF:M11601_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	137	0.000139	1
TF	TF:M09950_1	Factor: HSF1; motif: NRGAANNTTCYRGAA; match class: 1	Factor: HSF1; motif: NRGAANNTTCYRGAA; match class: 1	14	0.000188	1
TF	TF:M11656_1	Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1	Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1	13	0.000273	1
TF	TF:M03807	Factor: SP2; motif: GNNGGGGGCGGGGSN	Factor: SP2; motif: GNNGGGGGCGGGGSN	113	0.000301	1
TF	TF:M08526_1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	165	0.000364	1
TF	TF:M01783	Factor: SP2; motif: GGGCGGGAC	Factor: SP2; motif: GGGCGGGAC	119	0.000388	1
TF	TF:M12599_1	Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1	Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1	169	0.000465	1
TF	TF:M00931	Factor: Sp1; motif: GGGGCGGGGC	Factor: Sp1; motif: GGGGCGGGGC	129	0.000515	1
TF	TF:M07395	Factor: Sp1; motif: NGGGGCGGGGN	Factor: Sp1; motif: NGGGGCGGGGN	132	0.000545	1
TF	TF:M02070	Factor: TEL1; motif: CNCGGAANNN	Factor: TEL1; motif: CNCGGAANNN	133	0.000549	1
TF	TF:M08523	Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN	Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN	144	0.000577	1
TF	TF:M00932	Factor: Sp1; motif: NNGGGGCGGGGNN	Factor: Sp1; motif: NNGGGGCGGGGNN	130	0.000604	1
TF	TF:M08309	Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN	Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN	148	0.000623	1
TF	TF:M09765	Factor: SP1; motif: NRGKGGGCGGGGCN	Factor: SP1; motif: NRGKGGGCGGGGCN	103	0.000635	1
TF	TF:M02052	Factor: EHF; motif: CSCGGAARTN	Factor: EHF; motif: CSCGGAARTN	126	0.000753	1
TF	TF:M00716	Factor: ZF5; motif: GSGCGCGR	Factor: ZF5; motif: GSGCGCGR	171	0.000824	1
TF	TF:M11529_1	Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1	Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1	161	0.000874	1
TF	TF:M08205_1	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1	129	0.001291	1
TF	TF:M05361	Factor: Sp6; motif: WGGGCGG	Factor: Sp6; motif: WGGGCGG	112	0.001414	1
TF	TF:M05444	Factor: CPBP; motif: NGGGCGG	Factor: CPBP; motif: NGGGCGG	112	0.001414	1
TF	TF:M05332	Factor: Sp2; motif: WGGGCGG	Factor: Sp2; motif: WGGGCGG	112	0.001414	1
TF	TF:M07063	Factor: Sp1; motif: GGGGCGGGGC	Factor: Sp1; motif: GGGGCGGGGC	90	0.001491	1
TF	TF:M00736	Factor: E2F-1:DP-1; motif: TTTCSCGC	Factor: E2F-1:DP-1; motif: TTTCSCGC	128	0.001575	1
TF	TF:M11654_1	Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1	Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1	9	0.001911	1
TF	TF:M04826_1	Factor: p300; motif: ACNTCCG; match class: 1	Factor: p300; motif: ACNTCCG; match class: 1	165	0.001936	1
TF	TF:M02090	Factor: E2F-4; motif: GCGGGAAANA	Factor: E2F-4; motif: GCGGGAAANA	141	0.002133	1
TF	TF:M10072	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR	129	0.002528	1
TF	TF:M07409	Factor: BTEB2; motif: GCCCCRCCCH	Factor: BTEB2; motif: GCCCCRCCCH	78	0.003000	1
TF	TF:M02065_1	Factor: ER81; motif: RCCGGAARYN; match class: 1	Factor: ER81; motif: RCCGGAARYN; match class: 1	96	0.003060	1
TF	TF:M01588	Factor: GKLF; motif: GCCMCRCCCNNN	Factor: GKLF; motif: GCCMCRCCCNNN	114	0.003798	1
TF	TF:M02089	Factor: E2F-3; motif: GGCGGGN	Factor: E2F-3; motif: GGCGGGN	150	0.003804	1
TF	TF:M11529	Factor: E2F-2; motif: GCGCGCGCNCS	Factor: E2F-2; motif: GCGCGCGCNCS	171	0.003811	1
TF	TF:M04869_1	Factor: Egr-1; motif: GCGCATGCG; match class: 1	Factor: Egr-1; motif: GCGCATGCG; match class: 1	126	0.003925	1
TF	TF:M11655_1	Factor: HSF1; motif: NGAANGTTCKRGAAN; match class: 1	Factor: HSF1; motif: NGAANGTTCKRGAAN; match class: 1	8	0.003975	1
TF	TF:M11434	Factor: Elk-1; motif: NRSCGGAAGNN	Factor: Elk-1; motif: NRSCGGAAGNN	107	0.005277	1
TF	TF:M04869	Factor: Egr-1; motif: GCGCATGCG	Factor: Egr-1; motif: GCGCATGCG	134	0.005291	1
TF	TF:M00196_1	Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1	Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1	85	0.005489	1
TF	TF:M09892	Factor: E2F-1; motif: NNNNGGCGGGAARN	Factor: E2F-1; motif: NNNNGGCGGGAARN	152	0.006928	1
TF	TF:M02053	Factor: ELF1; motif: NCCGGAARTN	Factor: ELF1; motif: NCCGGAARTN	85	0.006975	1
TF	TF:M09970	Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN	Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN	102	0.007938	1
TF	TF:M02064	Factor: c-ets-2; motif: ACCGGAWRTN	Factor: c-ets-2; motif: ACCGGAWRTN	130	0.009376	1
TF	TF:M04826	Factor: p300; motif: ACNTCCG	Factor: p300; motif: ACNTCCG	178	0.009650	1
TF	TF:M07084	Factor: E2F-4; motif: NGGCGGGAARN	Factor: E2F-4; motif: NGGCGGGAARN	130	0.009733	1
TF	TF:M08309_1	Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN; match class: 1	Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN; match class: 1	95	0.010045	1
TF	TF:M00931_1	Factor: Sp1; motif: GGGGCGGGGC; match class: 1	Factor: Sp1; motif: GGGGCGGGGC; match class: 1	84	0.010192	1
TF	TF:M07206_1	Factor: E2F-1; motif: NGGGCGGGARV; match class: 1	Factor: E2F-1; motif: NGGGCGGGARV; match class: 1	130	0.010750	1
TF	TF:M04010	Factor: HSF4; motif: TTCTAGAANNTTC	Factor: HSF4; motif: TTCTAGAANNTTC	10	0.010996	1
TF	TF:M01023_1	Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 1	Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 1	12	0.011290	1
TF	TF:M12597	Factor: E2F1; motif: GSGCGGGAAN	Factor: E2F1; motif: GSGCGGGAAN	155	0.011525	1
TF	TF:M10530	Factor: sp4; motif: NNNGCYCCGCCCCCY	Factor: sp4; motif: NNNGCYCCGCCCCCY	106	0.011744	1
TF	TF:M08205	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT	158	0.011783	1
TF	TF:M02065	Factor: ER81; motif: RCCGGAARYN	Factor: ER81; motif: RCCGGAARYN	145	0.012175	1
TF	TF:M10438_1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	161	0.012327	1
TF	TF:M08313_1	Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1	Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1	119	0.012380	1
TF	TF:M00932_1	Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1	Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1	85	0.014069	1
TF	TF:M00803_1	Factor: E2F; motif: GGCGSG; match class: 1	Factor: E2F; motif: GGCGSG; match class: 1	124	0.014553	1
TF	TF:M09826	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC	136	0.014606	1
TF	TF:M07395_1	Factor: Sp1; motif: NGGGGCGGGGN; match class: 1	Factor: Sp1; motif: NGGGGCGGGGN; match class: 1	88	0.015033	1
TF	TF:M01240	Factor: BEN; motif: CAGCGRNV	Factor: BEN; motif: CAGCGRNV	171	0.016130	1
TF	TF:M13031_1	Factor: ETV4; motif: ACCGGAAGTN; match class: 1	Factor: ETV4; motif: ACCGGAAGTN; match class: 1	72	0.016942	1
TF	TF:M05361_1	Factor: Sp6; motif: WGGGCGG; match class: 1	Factor: Sp6; motif: WGGGCGG; match class: 1	55	0.017069	1
TF	TF:M05332_1	Factor: Sp2; motif: WGGGCGG; match class: 1	Factor: Sp2; motif: WGGGCGG; match class: 1	55	0.017069	1
TF	TF:M05444_1	Factor: CPBP; motif: NGGGCGG; match class: 1	Factor: CPBP; motif: NGGGCGG; match class: 1	55	0.017069	1
TF	TF:M11659_1	Factor: HSF4; motif: NGAANRTTCTAGAAN; match class: 1	Factor: HSF4; motif: NGAANRTTCTAGAAN; match class: 1	4	0.017100	1
TF	TF:M04008_1	Factor: HSF1; motif: TTCTAGAAYNTTC; match class: 1	Factor: HSF1; motif: TTCTAGAAYNTTC; match class: 1	4	0.017100	1
TF	TF:M00333	Factor: ZF5; motif: NRNGNGCGCGCWN	Factor: ZF5; motif: NRNGNGCGCGCWN	162	0.017444	1
TF	TF:M07615	Factor: Sp3; motif: GGGGCGGGGSNN	Factor: Sp3; motif: GGGGCGGGGSNN	92	0.018474	1
TF	TF:M11603_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	148	0.018489	1
TF	TF:M09636_1	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1	155	0.020215	1
TF	TF:M08377	Factor: meis1:Elf-1; motif: NTGCCGGAAGTN	Factor: meis1:Elf-1; motif: NTGCCGGAAGTN	132	0.020407	1
TF	TF:M08225_1	Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1	Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1	103	0.021527	1
TF	TF:M11657_1	Factor: HSF1; motif: NGAANRTTCKAGAAN; match class: 1	Factor: HSF1; motif: NGAANRTTCKAGAAN; match class: 1	4	0.023155	1
TF	TF:M07039	Factor: ETF; motif: CCCCGCCCCYN	Factor: ETF; motif: CCCCGCCCCYN	170	0.025122	1
TF	TF:M12668_1	Factor: SP2; motif: NNRRCCAATSRGNRNSNGSN; match class: 1	Factor: SP2; motif: NNRRCCAATSRGNRNSNGSN; match class: 1	81	0.025173	1
TF	TF:M10438	Factor: ZF5; motif: GGSGCGCGS	Factor: ZF5; motif: GGSGCGCGS	169	0.028035	1
TF	TF:M11018_1	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1	167	0.031477	1
TF	TF:M02036_1	Factor: WT1; motif: CGCCCCCNCN; match class: 1	Factor: WT1; motif: CGCCCCCNCN; match class: 1	76	0.033548	1
TF	TF:M11882_1	Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1	Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1	133	0.034724	1
TF	TF:M07226	Factor: SP1; motif: NCCCCKCCCCC	Factor: SP1; motif: NCCCCKCCCCC	105	0.037620	1
TF	TF:M02059	Factor: ELK-1; motif: ACCGGAAGTN	Factor: ELK-1; motif: ACCGGAAGTN	115	0.037767	1
TF	TF:M11018	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN	173	0.038970	1
TF	TF:M00933	Factor: Sp1; motif: CCCCGCCCCN	Factor: Sp1; motif: CCCCGCCCCN	118	0.041960	1
TF	TF:M02089_1	Factor: E2F-3; motif: GGCGGGN; match class: 1	Factor: E2F-3; motif: GGCGGGN; match class: 1	115	0.045610	1
TF	TF:M00803	Factor: E2F; motif: GGCGSG	Factor: E2F; motif: GGCGSG	147	0.047182	1

HP

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0100315	Lewy bodies	Lewy bodies	7	0.000535	1
HP	HP:0100314	Cerebral inclusion bodies	Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain.	8	0.002153	1
HP	HP:0045007	Abnormal substantia nigra morphology	A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry.	5	0.039562	1

Community 2

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	41	2.593921e-50	2
GO:BP	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	59	6.094068e-45	2
GO:BP	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	27	1.366166e-18	2
GO:BP	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	116	9.032324e-17	2
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	82	3.012648e-16	2
GO:BP	GO:0009059	macromolecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	116	6.180808e-15	2
GO:BP	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	127	2.534073e-13	2
GO:BP	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	23	2.317368e-12	2
GO:BP	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	16	2.625735e-12	2
GO:BP	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	14	1.995071e-11	2
GO:BP	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	18	2.995579e-11	2
GO:BP	GO:0016072	rRNA metabolic process	"The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732]	19	4.239429e-11	2
GO:BP	GO:0009058	biosynthetic process	"A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	116	6.447100e-11	2
GO:BP	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]	125	8.860925e-11	2
GO:BP	GO:1903311	regulation of mRNA metabolic process	"Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	19	7.468857e-10	2
GO:BP	GO:1903312	negative regulation of mRNA metabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	12	8.771599e-09	2
GO:BP	GO:2000767	positive regulation of cytoplasmic translation	"Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	7	1.126610e-08	2
GO:BP	GO:0051253	negative regulation of RNA metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	35	1.926224e-08	2
GO:BP	GO:0042255	ribosome assembly	"The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]	10	2.585233e-08	2
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	40	4.432601e-08	2
GO:BP	GO:0070934	CRD-mediated mRNA stabilization	"An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303]	6	7.143748e-08	2
GO:BP	GO:0008152	metabolic process	"A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	129	1.692876e-07	2
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	"Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	47	1.906542e-07	2
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	"Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	35	2.196593e-07	2
GO:BP	GO:0043489	RNA stabilization	"Prevention of degradation of RNA molecules." [GOC:go_curators]	10	2.334353e-07	2
GO:BP	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	72	3.396272e-07	2
GO:BP	GO:0051254	positive regulation of RNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	38	5.231686e-07	2
GO:BP	GO:0009891	positive regulation of biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	47	7.172856e-07	2
GO:BP	GO:0090304	nucleic acid metabolic process	"Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb]	87	7.767929e-07	2
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	"Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	59	1.035659e-06	2
GO:BP	GO:1902369	negative regulation of RNA catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457]	10	1.106161e-06	2
GO:BP	GO:0051252	regulation of RNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	56	1.368647e-06	2
GO:BP	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	9	1.728584e-06	2
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	52	1.870822e-06	2
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	"Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	39	2.729565e-06	2
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	50	4.434891e-06	2
GO:BP	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	54	5.090905e-06	2
GO:BP	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	14	5.559229e-06	2
GO:BP	GO:1902373	negative regulation of mRNA catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865]	9	5.926879e-06	2
GO:BP	GO:0043488	regulation of mRNA stability	"Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]	12	7.314917e-06	2
GO:BP	GO:2000765	regulation of cytoplasmic translation	"Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	7	9.000389e-06	2
GO:BP	GO:0140694	membraneless organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081]	17	1.078979e-05	2
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	"Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	45	1.392358e-05	2
GO:BP	GO:0016070	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	80	1.433716e-05	2
GO:BP	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	51	1.442244e-05	2
GO:BP	GO:1900151	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]	6	1.459503e-05	2
GO:BP	GO:0043487	regulation of RNA stability	"Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl]	12	1.509772e-05	2
GO:BP	GO:1900152	negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]	5	1.846187e-05	2
GO:BP	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]	8	1.896024e-05	2
GO:BP	GO:0061013	regulation of mRNA catabolic process	"Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]	12	2.011698e-05	2
GO:BP	GO:0009890	negative regulation of biosynthetic process	"Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	45	2.967687e-05	2
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	24	3.642492e-05	2
GO:BP	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	76	4.233348e-05	2
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	87	4.428672e-05	2
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	33	4.854036e-05	2
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	33	4.993443e-05	2
GO:BP	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	14	6.023407e-05	2
GO:BP	GO:1901796	regulation of signal transduction by p53 class mediator	"Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]	9	8.097690e-05	2
GO:BP	GO:1903313	positive regulation of mRNA metabolic process	"Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	10	9.731311e-05	2
GO:BP	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	25	1.440281e-04	2
GO:BP	GO:0141188	nucleic acid catabolic process	"The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators]	14	1.729504e-04	2
GO:BP	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	67	1.797896e-04	2
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	41	1.948685e-04	2
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	27	2.293958e-04	2
GO:BP	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	78	2.909998e-04	2
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	"Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	27	2.943272e-04	2
GO:BP	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	26	2.943531e-04	2
GO:BP	GO:0009895	negative regulation of catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	14	3.233305e-04	2
GO:BP	GO:0022613	ribonucleoprotein complex biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah]	33	3.673526e-04	2
GO:BP	GO:0000956	nuclear-transcribed mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]	9	3.873615e-04	2
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	"Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	67	3.945828e-04	2
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	26	5.864322e-04	2
GO:BP	GO:0050684	regulation of mRNA processing	"Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]	9	6.124860e-04	2
GO:BP	GO:2001242	regulation of intrinsic apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	10	6.730562e-04	2
GO:BP	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	41	7.649969e-04	2
GO:BP	GO:0061157	mRNA destabilization	"Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh]	8	8.591867e-04	2
GO:BP	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	7	8.693056e-04	2
GO:BP	GO:0032774	RNA biosynthetic process	"The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]	74	8.929827e-04	2
GO:BP	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	5	9.277550e-04	2
GO:BP	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	23	9.809622e-04	2
GO:BP	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	21	1.047046e-03	2
GO:BP	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	68	1.106930e-03	2
GO:BP	GO:0050779	RNA destabilization	"Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai]	8	1.154902e-03	2
GO:BP	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	47	1.208175e-03	2
GO:BP	GO:0061014	positive regulation of mRNA catabolic process	"Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]	8	1.241124e-03	2
GO:BP	GO:0009889	regulation of biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	67	1.242376e-03	2
GO:BP	GO:2001141	regulation of RNA biosynthetic process	"Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]	47	1.422214e-03	2
GO:BP	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	48	1.532391e-03	2
GO:BP	GO:0141187	nucleic acid biosynthetic process	"The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb]	74	1.813159e-03	2
GO:BP	GO:1901798	positive regulation of signal transduction by p53 class mediator	"Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]	5	2.098757e-03	2
GO:BP	GO:0097193	intrinsic apoptotic signaling pathway	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]	12	2.766593e-03	2
GO:BP	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	31	2.864281e-03	2
GO:BP	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	9	3.343296e-03	2
GO:BP	GO:0072331	signal transduction by p53 class mediator	"An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah]	9	3.343296e-03	2
GO:BP	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	16	3.437698e-03	2
GO:BP	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	69	4.434961e-03	2
GO:BP	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	29	4.616364e-03	2
GO:BP	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	8	6.079701e-03	2
GO:BP	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	20	6.311396e-03	2
GO:BP	GO:0034655	nucleobase-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	15	6.843179e-03	2
GO:BP	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	21	7.980038e-03	2
GO:BP	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	12	8.273425e-03	2
GO:BP	GO:0016071	mRNA metabolic process	"The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	33	9.514516e-03	2
GO:BP	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	44	9.531603e-03	2
GO:BP	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	9	9.817184e-03	2
GO:BP	GO:0000028	ribosomal small subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl, PMID:30467428]	4	1.040862e-02	2
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	74	1.056996e-02	2
GO:BP	GO:0032200	telomere organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah]	9	1.165624e-02	2
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	21	1.349588e-02	2
GO:BP	GO:0034101	erythrocyte homeostasis	"Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397]	8	1.350363e-02	2
GO:BP	GO:0010586	miRNA metabolic process	"The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]	7	1.441785e-02	2
GO:BP	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	17	1.619460e-02	2
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	25	1.764792e-02	2
GO:BP	GO:2001233	regulation of apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	12	2.068438e-02	2
GO:BP	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	7	2.071920e-02	2
GO:BP	GO:0032204	regulation of telomere maintenance	"Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]	7	2.071920e-02	2
GO:BP	GO:0042752	regulation of circadian rhythm	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]	7	2.326822e-02	2
GO:BP	GO:0007623	circadian rhythm	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]	9	2.497825e-02	2
GO:BP	GO:0051248	negative regulation of protein metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]	16	2.746433e-02	2
GO:BP	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	15	3.012440e-02	2
GO:BP	GO:0032873	negative regulation of stress-activated MAPK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]	3	4.484244e-02	2
GO:BP	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	18	4.960520e-02	2

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0022626	cytosolic ribosome	"A ribosome located in the cytosol." [GOC:mtg_sensu]	35	3.082044e-47	2
GO:CC	GO:0044391	ribosomal subunit	"Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl]	35	5.825350e-39	2
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	111	9.051805e-29	2
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	111	9.185650e-29	2
GO:CC	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	101	1.665632e-27	2
GO:CC	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	38	1.501430e-26	2
GO:CC	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	88	5.995653e-26	2
GO:CC	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	17	1.966564e-24	2
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	106	2.449224e-24	2
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	106	2.449224e-24	2
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	106	2.449224e-24	2
GO:CC	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	17	4.910553e-22	2
GO:CC	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	67	1.162536e-21	2
GO:CC	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	18	4.646450e-21	2
GO:CC	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	122	4.690348e-20	2
GO:CC	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	17	3.879598e-16	2
GO:CC	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	50	2.922622e-15	2
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	142	7.681615e-15	2
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	83	2.442146e-14	2
GO:CC	GO:0030684	preribosome	"Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516]	15	1.194981e-13	2
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	143	2.317379e-13	2
GO:CC	GO:0035770	ribonucleoprotein granule	"A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]	20	5.910155e-13	2
GO:CC	GO:0036464	cytoplasmic ribonucleoprotein granule	"A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]	19	2.193849e-12	2
GO:CC	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	13	1.261005e-11	2
GO:CC	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	12	1.662623e-11	2
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	22	2.133128e-11	2
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	22	3.412128e-11	2
GO:CC	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	133	5.482469e-11	2
GO:CC	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	95	7.030358e-11	2
GO:CC	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	137	8.512479e-11	2
GO:CC	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	16	2.014235e-10	2
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	143	7.583319e-10	2
GO:CC	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	42	1.357402e-09	2
GO:CC	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	11	6.413164e-09	2
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	43	1.194210e-07	2
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	35	1.327239e-07	2
GO:CC	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	25	2.390743e-07	2
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	115	1.094559e-06	2
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	37	5.365642e-06	2
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	37	7.785478e-06	2
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	37	7.881646e-06	2
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	37	7.881646e-06	2
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	23	8.605698e-06	2
GO:CC	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640]	15	3.636675e-05	2
GO:CC	GO:0016363	nuclear matrix	"A dynamic, proteinaceous framework within the nucleus of eukaryotic cells, composed of proteins and RNA, that provides structural support for chromatin organization, gene regulation, and nuclear processes." [PMID:15608168, PMID:3058729, PMID:39789220]	8	7.316384e-04	2
GO:CC	GO:0099080	supramolecular complex	"A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]	26	7.339474e-04	2
GO:CC	GO:0098687	chromosomal region	"Any subdivision of a chromosome along its length." [GOC:dos]	13	8.796265e-04	2
GO:CC	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	4	1.040711e-03	2
GO:CC	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	25	1.379986e-03	2
GO:CC	GO:0070937	CRD-mediated mRNA stability complex	"A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9." [GOC:mah, PMID:19029303]	3	1.881610e-03	2
GO:CC	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	8	5.863106e-03	2
GO:CC	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	9	8.517368e-03	2
GO:CC	GO:0034399	nuclear periphery	"The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]	4	1.460028e-02	2
GO:CC	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	3	1.515670e-02	2
GO:CC	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	5	1.705364e-02	2
GO:CC	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	16	1.732939e-02	2
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	40	1.880812e-02	2
GO:CC	GO:0042382	paraspeckles	"Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299]	3	2.602191e-02	2
GO:CC	GO:0005652	nuclear lamina	"The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]	3	3.296110e-02	2
GO:CC	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density]	10	4.202939e-02	2
GO:CC	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	5	4.599752e-02	2

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-156842	Eukaryotic Translation Elongation	Eukaryotic Translation Elongation	36	2.065748e-46	2
REAC	REAC:R-HSA-156902	Peptide chain elongation	Peptide chain elongation	35	2.688332e-45	2
REAC	REAC:R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	SRP-dependent cotranslational protein targeting to membrane	37	8.913213e-45	2
REAC	REAC:R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	L13a-mediated translational silencing of Ceruloplasmin expression	36	4.130714e-43	2
REAC	REAC:R-HSA-72689	Formation of a pool of free 40S subunits	Formation of a pool of free 40S subunits	35	5.570135e-43	2
REAC	REAC:R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	34	3.333671e-42	2
REAC	REAC:R-HSA-72613	Eukaryotic Translation Initiation	Eukaryotic Translation Initiation	36	7.534042e-42	2
REAC	REAC:R-HSA-72737	Cap-dependent Translation Initiation	Cap-dependent Translation Initiation	36	7.534042e-42	2
REAC	REAC:R-HSA-192823	Viral mRNA Translation	Viral mRNA Translation	33	1.864465e-41	2
REAC	REAC:R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	GTP hydrolysis and joining of the 60S ribosomal subunit	35	3.855438e-41	2
REAC	REAC:R-HSA-72764	Eukaryotic Translation Termination	Eukaryotic Translation Termination	33	1.058851e-40	2
REAC	REAC:R-HSA-2408557	Selenocysteine synthesis	Selenocysteine synthesis	33	1.058851e-40	2
REAC	REAC:R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	Response of EIF2AK4 (GCN2) to amino acid deficiency	33	2.622844e-39	2
REAC	REAC:R-HSA-927802	Nonsense-Mediated Decay (NMD)	Nonsense-Mediated Decay (NMD)	34	6.556590e-39	2
REAC	REAC:R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	34	6.556590e-39	2
REAC	REAC:R-HSA-72766	Translation	Translation	44	7.935755e-38	2
REAC	REAC:R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	Major pathway of rRNA processing in the nucleolus and cytosol	38	1.041708e-37	2
REAC	REAC:R-HSA-2408522	Selenoamino acid metabolism	Selenoamino acid metabolism	33	5.023338e-37	2
REAC	REAC:R-HSA-8868773	rRNA processing in the nucleus and cytosol	rRNA processing in the nucleus and cytosol	38	9.380619e-37	2
REAC	REAC:R-HSA-168273	Influenza Viral RNA Transcription and Replication	Influenza Viral RNA Transcription and Replication	34	1.297993e-36	2
REAC	REAC:R-HSA-72312	rRNA processing	rRNA processing	38	7.432039e-36	2
REAC	REAC:R-HSA-8953854	Metabolism of RNA	Metabolism of RNA	57	2.031207e-35	2
REAC	REAC:R-HSA-168255	Influenza Infection	Influenza Infection	34	3.241959e-34	2
REAC	REAC:R-HSA-9010553	Regulation of expression of SLITs and ROBOs	Regulation of expression of SLITs and ROBOs	34	1.540204e-32	2
REAC	REAC:R-HSA-9711097	Cellular response to starvation	Cellular response to starvation	33	2.452229e-32	2
REAC	REAC:R-HSA-376176	Signaling by ROBO receptors	Signaling by ROBO receptors	35	3.100336e-30	2
REAC	REAC:R-HSA-9735869	SARS-CoV-1 modulates host translation machinery	SARS-CoV-1 modulates host translation machinery	17	2.873988e-22	2
REAC	REAC:R-HSA-72649	Translation initiation complex formation	Translation initiation complex formation	19	1.623818e-21	2
REAC	REAC:R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	19	2.356950e-21	2
REAC	REAC:R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	Formation of the ternary complex, and subsequently, the 43S complex	18	6.010351e-21	2
REAC	REAC:R-HSA-71291	Metabolism of amino acids and derivatives	Metabolism of amino acids and derivatives	33	4.743632e-20	2
REAC	REAC:R-HSA-72702	Ribosomal scanning and start codon recognition	Ribosomal scanning and start codon recognition	18	8.608836e-20	2
REAC	REAC:R-HSA-422475	Axon guidance	Axon guidance	37	1.672600e-18	2
REAC	REAC:R-HSA-2262752	Cellular responses to stress	Cellular responses to stress	43	3.442846e-18	2
REAC	REAC:R-HSA-8953897	Cellular responses to stimuli	Cellular responses to stimuli	43	6.770616e-18	2
REAC	REAC:R-HSA-9675108	Nervous system development	Nervous system development	37	7.841023e-18	2
REAC	REAC:R-HSA-9754678	SARS-CoV-2 modulates host translation machinery	SARS-CoV-2 modulates host translation machinery	16	1.294062e-17	2
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	47	1.041013e-16	2
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	43	1.206993e-16	2
REAC	REAC:R-HSA-9692914	SARS-CoV-1-host interactions	SARS-CoV-1-host interactions	17	2.861706e-14	2
REAC	REAC:R-HSA-1643685	Disease	Disease	57	5.795057e-14	2
REAC	REAC:R-HSA-9678108	SARS-CoV-1 Infection	SARS-CoV-1 Infection	19	8.174023e-14	2
REAC	REAC:R-HSA-392499	Metabolism of proteins	Metabolism of proteins	59	4.796703e-13	2
REAC	REAC:R-HSA-1266738	Developmental Biology	Developmental Biology	46	2.048788e-11	2
REAC	REAC:R-HSA-9705683	SARS-CoV-2-host interactions	SARS-CoV-2-host interactions	16	6.967219e-08	2
REAC	REAC:R-HSA-9694516	SARS-CoV-2 Infection	SARS-CoV-2 Infection	18	4.182779e-07	2
REAC	REAC:R-HSA-72163	mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway	15	9.554208e-07	2
REAC	REAC:R-HSA-72172	mRNA Splicing	mRNA Splicing	15	1.528592e-06	2
REAC	REAC:R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	Processing of Capped Intron-Containing Pre-mRNA	16	9.458097e-06	2
REAC	REAC:R-HSA-9679506	SARS-CoV Infections	SARS-CoV Infections	20	1.741632e-05	2
REAC	REAC:R-HSA-9629569	Protein hydroxylation	Protein hydroxylation	4	2.142524e-02	2

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	99	1.055904e-44	2
GO:MF	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	114	1.899572e-36	2
GO:MF	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	33	2.077772e-21	2
GO:MF	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	28	1.580514e-17	2
GO:MF	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	37	8.370824e-13	2
GO:MF	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	12	3.682806e-11	2
GO:MF	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	14	1.786560e-08	2
GO:MF	GO:0120545	nucleic acid conformation isomerase activity	"Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-]	13	1.655919e-07	2
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	136	2.710583e-07	2
GO:MF	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	12	1.039129e-06	2
GO:MF	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	10	5.920998e-06	2
GO:MF	GO:0048027	mRNA 5'-UTR binding	"Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid]	6	9.541517e-06	2
GO:MF	GO:0120543	macromolecular conformation isomerase activity	"Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-]	14	1.407833e-05	2
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	37	9.875708e-05	2
GO:MF	GO:0140517	protein-RNA adaptor activity	"The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way." [PMID:24470144]	5	1.230918e-04	2
GO:MF	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	41	1.730697e-04	2
GO:MF	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	7	7.798951e-04	2
GO:MF	GO:1990247	N6-methyladenosine-containing RNA reader activity	"A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625]	4	7.853388e-04	2
GO:MF	GO:0008186	ATP-dependent activity, acting on RNA	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl]	7	9.313757e-04	2
GO:MF	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	8	1.770502e-03	2
GO:MF	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	8	2.000253e-03	2
GO:MF	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	5	2.703207e-03	2
GO:MF	GO:0016853	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	14	2.961852e-03	2
GO:MF	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	13	5.285453e-03	2
GO:MF	GO:0008312	7S RNA binding	"Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]	3	8.161035e-03	2
GO:MF	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	16	8.348916e-03	2
GO:MF	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	11	8.352271e-03	2
GO:MF	GO:0044389	ubiquitin-like protein ligase binding	"Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]	11	1.419419e-02	2
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	11	1.928630e-02	2
GO:MF	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	143	2.135991e-02	2
GO:MF	GO:1990948	ubiquitin ligase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a ubiquitin ligase." [GOC:dph, GOC:vw, PMID:21389117]	3	2.754514e-02	2
GO:MF	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	15	2.773369e-02	2
GO:MF	GO:0180051	translation factor activity	"A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation." [GOC:pg]	6	3.196013e-02	2
GO:MF	GO:0160123	structural constituent of nuclear lamina	"The action of a molecule that contributes to the structural integrity of nuclear lamina." [PMID:2824113, PMID:31434876]	2	3.394531e-02	2
GO:MF	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	5	4.216693e-02	2

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP477	Cytoplasmic ribosomal proteins	Cytoplasmic ribosomal proteins	33	3.180713e-40	2
WP	WP:WP411	mRNA processing	mRNA processing	17	1.787957e-11	2
WP	WP:WP3594	Circadian rhythm genes	Circadian rhythm genes	11	4.967024e-03	2
WP	WP:WP107	Translation factors	Translation factors	6	5.164560e-03	2
WP	WP:WP314	Fas ligand pathway and stress induction of heat shock proteins	Fas ligand pathway and stress induction of heat shock proteins	5	2.606525e-02	2
WP	WP:WP3888	VEGFA VEGFR2 signaling	VEGFA VEGFR2 signaling	15	3.372225e-02	2

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:3055	Nop56p-associated pre-rRNA complex	Nop56p-associated pre-rRNA complex	36	1.733470e-34	2
CORUM	CORUM:306	Ribosome, cytoplasmic	Ribosome, cytoplasmic	30	9.019141e-29	2
CORUM	CORUM:338	40S ribosomal subunit, cytoplasmic	40S ribosomal subunit, cytoplasmic	15	2.423363e-15	2
CORUM	CORUM:305	40S ribosomal subunit, cytoplasmic	40S ribosomal subunit, cytoplasmic	15	9.032243e-15	2
CORUM	CORUM:308	60S ribosomal subunit, cytoplasmic	60S ribosomal subunit, cytoplasmic	15	3.604866e-12	2
CORUM	CORUM:1332	Large Drosha complex	Large Drosha complex	6	1.026218e-03	2
CORUM	CORUM:1181	C complex spliceosome	C complex spliceosome	10	2.616325e-03	2
CORUM	CORUM:6838	IGF2BP1 complex	IGF2BP1 complex	4	7.243112e-03	2
CORUM	CORUM:3082	DGCR8 multiprotein complex	DGCR8 multiprotein complex	4	1.184386e-02	2

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:03010	Ribosome	Ribosome	33	1.494760e-32	2
KEGG	KEGG:05171	Coronavirus disease - COVID-19	Coronavirus disease - COVID-19	34	1.131990e-27	2
KEGG	KEGG:03040	Spliceosome	Spliceosome	11	3.298378e-04	2

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0100133	Cerebral cortex; neuronal cells[High]	Cerebral cortex; neuronal cells[High]	68	1.727742e-19	2
HPA	HPA:0630222	Cervix; squamous epithelial cells[≥Medium]	Cervix; squamous epithelial cells[≥Medium]	93	4.163462e-18	2
HPA	HPA:0600432	Tonsil; germinal center cells[≥Medium]	Tonsil; germinal center cells[≥Medium]	97	6.992569e-18	2
HPA	HPA:0190223	Esophagus; squamous epithelial cells[High]	Esophagus; squamous epithelial cells[High]	62	1.590866e-17	2
HPA	HPA:0350473	Pancreas; exocrine glandular cells[High]	Pancreas; exocrine glandular cells[High]	66	1.545602e-16	2
HPA	HPA:0310431	Lymph node; germinal center cells[≥Low]	Lymph node; germinal center cells[≥Low]	104	1.327118e-15	2
HPA	HPA:0170252	Endometrium 2; cells in endometrial stroma[≥Medium]	Endometrium 2; cells in endometrial stroma[≥Medium]	62	1.412260e-15	2
HPA	HPA:0600433	Tonsil; germinal center cells[High]	Tonsil; germinal center cells[High]	51	2.840829e-15	2
HPA	HPA:0250133	Hippocampus; neuronal cells[High]	Hippocampus; neuronal cells[High]	51	7.713210e-15	2
HPA	HPA:0600223	Tonsil; squamous epithelial cells[High]	Tonsil; squamous epithelial cells[High]	55	8.745632e-15	2
HPA	HPA:0630223	Cervix; squamous epithelial cells[High]	Cervix; squamous epithelial cells[High]	46	1.637960e-14	2
HPA	HPA:0620223	Vagina; squamous epithelial cells[High]	Vagina; squamous epithelial cells[High]	48	2.201520e-14	2
HPA	HPA:0330223	Oral mucosa; squamous epithelial cells[High]	Oral mucosa; squamous epithelial cells[High]	48	3.600323e-14	2
HPA	HPA:0090192	Cerebellum; cells in molecular layer[≥Medium]	Cerebellum; cells in molecular layer[≥Medium]	75	4.961498e-14	2
HPA	HPA:0620222	Vagina; squamous epithelial cells[≥Medium]	Vagina; squamous epithelial cells[≥Medium]	91	5.305907e-14	2
HPA	HPA:0420053	Salivary gland; glandular cells[High]	Salivary gland; glandular cells[High]	54	6.145819e-14	2
HPA	HPA:0170053	Endometrium 2; glandular cells[High]	Endometrium 2; glandular cells[High]	51	9.248558e-14	2
HPA	HPA:0050053	Breast; glandular cells[High]	Breast; glandular cells[High]	51	1.524568e-13	2
HPA	HPA:0190222	Esophagus; squamous epithelial cells[≥Medium]	Esophagus; squamous epithelial cells[≥Medium]	101	2.124526e-13	2
HPA	HPA:0550053	Stomach 2; glandular cells[High]	Stomach 2; glandular cells[High]	68	6.740989e-13	2
HPA	HPA:0630221	Cervix; squamous epithelial cells[≥Low]	Cervix; squamous epithelial cells[≥Low]	104	9.076018e-13	2
HPA	HPA:0250132	Hippocampus; neuronal cells[≥Medium]	Hippocampus; neuronal cells[≥Medium]	91	1.175545e-12	2
HPA	HPA:0310000	Lymph node	Lymph node	113	1.862685e-12	2
HPA	HPA:0170251	Endometrium 2; cells in endometrial stroma[≥Low]	Endometrium 2; cells in endometrial stroma[≥Low]	82	2.408226e-12	2
HPA	HPA:0300203	Lung; endothelial cells[High]	Lung; endothelial cells[High]	24	4.866667e-12	2
HPA	HPA:0620000	Vagina	Vagina	108	4.916687e-12	2
HPA	HPA:0620221	Vagina; squamous epithelial cells[≥Low]	Vagina; squamous epithelial cells[≥Low]	108	4.916687e-12	2
HPA	HPA:0080133	Caudate; neuronal cells[High]	Caudate; neuronal cells[High]	44	5.723037e-12	2
HPA	HPA:0100132	Cerebral cortex; neuronal cells[≥Medium]	Cerebral cortex; neuronal cells[≥Medium]	98	7.722867e-12	2
HPA	HPA:0090163	Cerebellum; Purkinje cells[High]	Cerebellum; Purkinje cells[High]	52	9.580054e-12	2
HPA	HPA:0310432	Lymph node; germinal center cells[≥Medium]	Lymph node; germinal center cells[≥Medium]	78	1.351237e-11	2
HPA	HPA:0080132	Caudate; neuronal cells[≥Medium]	Caudate; neuronal cells[≥Medium]	88	1.415738e-11	2
HPA	HPA:0040083	Bone marrow; hematopoietic cells[High]	Bone marrow; hematopoietic cells[High]	50	1.605639e-11	2
HPA	HPA:0600222	Tonsil; squamous epithelial cells[≥Medium]	Tonsil; squamous epithelial cells[≥Medium]	97	1.693318e-11	2
HPA	HPA:0160251	Endometrium 1; cells in endometrial stroma[≥Low]	Endometrium 1; cells in endometrial stroma[≥Low]	87	3.164109e-11	2
HPA	HPA:0330222	Oral mucosa; squamous epithelial cells[≥Medium]	Oral mucosa; squamous epithelial cells[≥Medium]	90	4.223964e-11	2
HPA	HPA:0500653	Soft tissue 1; fibroblasts[High]	Soft tissue 1; fibroblasts[High]	30	5.632575e-11	2
HPA	HPA:0090162	Cerebellum; Purkinje cells[≥Medium]	Cerebellum; Purkinje cells[≥Medium]	87	6.114925e-11	2
HPA	HPA:0600221	Tonsil; squamous epithelial cells[≥Low]	Tonsil; squamous epithelial cells[≥Low]	112	6.290579e-11	2
HPA	HPA:0600431	Tonsil; germinal center cells[≥Low]	Tonsil; germinal center cells[≥Low]	106	1.068145e-10	2
HPA	HPA:0160053	Endometrium 1; glandular cells[High]	Endometrium 1; glandular cells[High]	49	1.091822e-10	2
HPA	HPA:0170052	Endometrium 2; glandular cells[≥Medium]	Endometrium 2; glandular cells[≥Medium]	95	1.286533e-10	2
HPA	HPA:0380000	Placenta	Placenta	118	1.560129e-10	2
HPA	HPA:0090193	Cerebellum; cells in molecular layer[High]	Cerebellum; cells in molecular layer[High]	38	1.921062e-10	2
HPA	HPA:0350472	Pancreas; exocrine glandular cells[≥Medium]	Pancreas; exocrine glandular cells[≥Medium]	99	1.949539e-10	2
HPA	HPA:0160252	Endometrium 1; cells in endometrial stroma[≥Medium]	Endometrium 1; cells in endometrial stroma[≥Medium]	61	2.095416e-10	2
HPA	HPA:0340461	Ovary; ovarian stroma cells[≥Low]	Ovary; ovarian stroma cells[≥Low]	84	4.036909e-10	2
HPA	HPA:0530721	Spleen; cells in white pulp[≥Low]	Spleen; cells in white pulp[≥Low]	88	4.919924e-10	2
HPA	HPA:0350471	Pancreas; exocrine glandular cells[≥Low]	Pancreas; exocrine glandular cells[≥Low]	113	6.408389e-10	2
HPA	HPA:0310441	Lymph node; non-germinal center cells[≥Low]	Lymph node; non-germinal center cells[≥Low]	105	1.327721e-09	2
HPA	HPA:0610832	Urinary bladder; urothelial cells[≥Medium]	Urinary bladder; urothelial cells[≥Medium]	104	1.334824e-09	2
HPA	HPA:0301373	Lung; alveolar cells type II[High]	Lung; alveolar cells type II[High]	31	1.892737e-09	2
HPA	HPA:0040082	Bone marrow; hematopoietic cells[≥Medium]	Bone marrow; hematopoietic cells[≥Medium]	86	1.926431e-09	2
HPA	HPA:0610000	Urinary bladder	Urinary bladder	115	2.428495e-09	2
HPA	HPA:0610831	Urinary bladder; urothelial cells[≥Low]	Urinary bladder; urothelial cells[≥Low]	115	2.428495e-09	2
HPA	HPA:0190221	Esophagus; squamous epithelial cells[≥Low]	Esophagus; squamous epithelial cells[≥Low]	110	2.517117e-09	2
HPA	HPA:0190000	Esophagus	Esophagus	110	2.517117e-09	2
HPA	HPA:0461411	Skin 1; cells in spinous layer[≥Low]	Skin 1; cells in spinous layer[≥Low]	33	2.553958e-09	2
HPA	HPA:0610833	Urinary bladder; urothelial cells[High]	Urinary bladder; urothelial cells[High]	56	2.845994e-09	2
HPA	HPA:0460671	Skin 1; melanocytes[≥Low]	Skin 1; melanocytes[≥Low]	97	2.908089e-09	2
HPA	HPA:0510703	Soft tissue 2; peripheral nerve[High]	Soft tissue 2; peripheral nerve[High]	21	3.304994e-09	2
HPA	HPA:0210000	Fallopian tube	Fallopian tube	116	3.807027e-09	2
HPA	HPA:0471412	Skin 2; cells in spinous layer[≥Medium]	Skin 2; cells in spinous layer[≥Medium]	31	4.080945e-09	2
HPA	HPA:0310442	Lymph node; non-germinal center cells[≥Medium]	Lymph node; non-germinal center cells[≥Medium]	82	5.267864e-09	2
HPA	HPA:0460673	Skin 1; melanocytes[High]	Skin 1; melanocytes[High]	37	7.666264e-09	2
HPA	HPA:0600442	Tonsil; non-germinal center cells[≥Medium]	Tonsil; non-germinal center cells[≥Medium]	84	1.003468e-08	2
HPA	HPA:0460672	Skin 1; melanocytes[≥Medium]	Skin 1; melanocytes[≥Medium]	78	1.028929e-08	2
HPA	HPA:0460181	Skin 1; cells in granular layer[≥Low]	Skin 1; cells in granular layer[≥Low]	31	1.141556e-08	2
HPA	HPA:0630000	Cervix	Cervix	111	1.301638e-08	2
HPA	HPA:0050051	Breast; glandular cells[≥Low]	Breast; glandular cells[≥Low]	110	1.427122e-08	2
HPA	HPA:0050000	Breast	Breast	113	1.542772e-08	2
HPA	HPA:0301363	Lung; alveolar cells type I[High]	Lung; alveolar cells type I[High]	26	1.707517e-08	2
HPA	HPA:0340462	Ovary; ovarian stroma cells[≥Medium]	Ovary; ovarian stroma cells[≥Medium]	55	1.823319e-08	2
HPA	HPA:0461392	Skin 1; cells in basal layer[≥Medium]	Skin 1; cells in basal layer[≥Medium]	29	2.060446e-08	2
HPA	HPA:0170051	Endometrium 2; glandular cells[≥Low]	Endometrium 2; glandular cells[≥Low]	109	2.092699e-08	2
HPA	HPA:0471411	Skin 2; cells in spinous layer[≥Low]	Skin 2; cells in spinous layer[≥Low]	34	2.143874e-08	2
HPA	HPA:0080123	Caudate; glial cells[High]	Caudate; glial cells[High]	30	2.265870e-08	2
HPA	HPA:0160253	Endometrium 1; cells in endometrial stroma[High]	Endometrium 1; cells in endometrial stroma[High]	24	2.426342e-08	2
HPA	HPA:0460182	Skin 1; cells in granular layer[≥Medium]	Skin 1; cells in granular layer[≥Medium]	27	2.585472e-08	2
HPA	HPA:0461391	Skin 1; cells in basal layer[≥Low]	Skin 1; cells in basal layer[≥Low]	34	2.920882e-08	2
HPA	HPA:0510653	Soft tissue 2; fibroblasts[High]	Soft tissue 2; fibroblasts[High]	26	3.247618e-08	2
HPA	HPA:0050093	Breast; myoepithelial cells[High]	Breast; myoepithelial cells[High]	33	3.383878e-08	2
HPA	HPA:0300202	Lung; endothelial cells[≥Medium]	Lung; endothelial cells[≥Medium]	29	3.464808e-08	2
HPA	HPA:0050052	Breast; glandular cells[≥Medium]	Breast; glandular cells[≥Medium]	93	3.636790e-08	2
HPA	HPA:0100123	Cerebral cortex; glial cells[High]	Cerebral cortex; glial cells[High]	31	3.846018e-08	2
HPA	HPA:0500652	Soft tissue 1; fibroblasts[≥Medium]	Soft tissue 1; fibroblasts[≥Medium]	64	4.007532e-08	2
HPA	HPA:0600000	Tonsil	Tonsil	117	4.051457e-08	2
HPA	HPA:0250131	Hippocampus; neuronal cells[≥Low]	Hippocampus; neuronal cells[≥Low]	104	4.392792e-08	2
HPA	HPA:0220051	Gallbladder; glandular cells[≥Low]	Gallbladder; glandular cells[≥Low]	116	4.402449e-08	2
HPA	HPA:0220000	Gallbladder	Gallbladder	116	4.402449e-08	2
HPA	HPA:0380513	Placenta; decidual cells[High]	Placenta; decidual cells[High]	40	4.456160e-08	2
HPA	HPA:0540051	Stomach 1; glandular cells[≥Low]	Stomach 1; glandular cells[≥Low]	116	4.631583e-08	2
HPA	HPA:0540000	Stomach 1	Stomach 1	116	4.631583e-08	2
HPA	HPA:0540053	Stomach 1; glandular cells[High]	Stomach 1; glandular cells[High]	60	4.710351e-08	2
HPA	HPA:0600441	Tonsil; non-germinal center cells[≥Low]	Tonsil; non-germinal center cells[≥Low]	103	4.826236e-08	2
HPA	HPA:0471462	Skin 2; langerhans cells[≥Medium]	Skin 2; langerhans cells[≥Medium]	29	4.978834e-08	2
HPA	HPA:0350000	Pancreas	Pancreas	114	5.095224e-08	2
HPA	HPA:0471392	Skin 2; cells in basal layer[≥Medium]	Skin 2; cells in basal layer[≥Medium]	31	5.193611e-08	2
HPA	HPA:0540052	Stomach 1; glandular cells[≥Medium]	Stomach 1; glandular cells[≥Medium]	105	5.439616e-08	2
HPA	HPA:0380512	Placenta; decidual cells[≥Medium]	Placenta; decidual cells[≥Medium]	75	6.080953e-08	2
HPA	HPA:0530711	Spleen; cells in red pulp[≥Low]	Spleen; cells in red pulp[≥Low]	95	6.424568e-08	2
HPA	HPA:0330000	Oral mucosa	Oral mucosa	104	6.561757e-08	2
HPA	HPA:0330221	Oral mucosa; squamous epithelial cells[≥Low]	Oral mucosa; squamous epithelial cells[≥Low]	104	6.561757e-08	2
HPA	HPA:0461461	Skin 1; langerhans cells[≥Low]	Skin 1; langerhans cells[≥Low]	30	6.691384e-08	2
HPA	HPA:0400000	Rectum	Rectum	118	6.828863e-08	2
HPA	HPA:0160052	Endometrium 1; glandular cells[≥Medium]	Endometrium 1; glandular cells[≥Medium]	93	6.877566e-08	2
HPA	HPA:0430051	Seminal vesicle; glandular cells[≥Low]	Seminal vesicle; glandular cells[≥Low]	109	7.542437e-08	2
HPA	HPA:0430000	Seminal vesicle	Seminal vesicle	109	7.542437e-08	2
HPA	HPA:0550052	Stomach 2; glandular cells[≥Medium]	Stomach 2; glandular cells[≥Medium]	104	8.955047e-08	2
HPA	HPA:0320000	Nasopharynx	Nasopharynx	112	9.146571e-08	2
HPA	HPA:0060103	Bronchus; respiratory epithelial cells[High]	Bronchus; respiratory epithelial cells[High]	50	9.499572e-08	2
HPA	HPA:0461412	Skin 1; cells in spinous layer[≥Medium]	Skin 1; cells in spinous layer[≥Medium]	27	9.780558e-08	2
HPA	HPA:0090191	Cerebellum; cells in molecular layer[≥Low]	Cerebellum; cells in molecular layer[≥Low]	85	1.002430e-07	2
HPA	HPA:0470672	Skin 2; melanocytes[≥Medium]	Skin 2; melanocytes[≥Medium]	28	1.127228e-07	2
HPA	HPA:0530722	Spleen; cells in white pulp[≥Medium]	Spleen; cells in white pulp[≥Medium]	63	1.194000e-07	2
HPA	HPA:0210053	Fallopian tube; glandular cells[High]	Fallopian tube; glandular cells[High]	47	1.205411e-07	2
HPA	HPA:0320103	Nasopharynx; respiratory epithelial cells[High]	Nasopharynx; respiratory epithelial cells[High]	49	1.374743e-07	2
HPA	HPA:0530000	Spleen	Spleen	100	1.436028e-07	2
HPA	HPA:0460000	Skin 1	Skin 1	112	1.516274e-07	2
HPA	HPA:0470182	Skin 2; cells in granular layer[≥Medium]	Skin 2; cells in granular layer[≥Medium]	26	1.681942e-07	2
HPA	HPA:0420051	Salivary gland; glandular cells[≥Low]	Salivary gland; glandular cells[≥Low]	109	1.871957e-07	2
HPA	HPA:0420000	Salivary gland	Salivary gland	109	1.871957e-07	2
HPA	HPA:0420052	Salivary gland; glandular cells[≥Medium]	Salivary gland; glandular cells[≥Medium]	89	2.151274e-07	2
HPA	HPA:0170000	Endometrium 2	Endometrium 2	109	2.300947e-07	2
HPA	HPA:0390052	Prostate; glandular cells[≥Medium]	Prostate; glandular cells[≥Medium]	88	2.976433e-07	2
HPA	HPA:0471391	Skin 2; cells in basal layer[≥Low]	Skin 2; cells in basal layer[≥Low]	34	3.041134e-07	2
HPA	HPA:0040000	Bone marrow	Bone marrow	105	3.338819e-07	2
HPA	HPA:0040081	Bone marrow; hematopoietic cells[≥Low]	Bone marrow; hematopoietic cells[≥Low]	105	3.338819e-07	2
HPA	HPA:0630053	Cervix; glandular cells[High]	Cervix; glandular cells[High]	38	3.458484e-07	2
HPA	HPA:0220052	Gallbladder; glandular cells[≥Medium]	Gallbladder; glandular cells[≥Medium]	106	3.516189e-07	2
HPA	HPA:0470181	Skin 2; cells in granular layer[≥Low]	Skin 2; cells in granular layer[≥Low]	29	3.573773e-07	2
HPA	HPA:0360051	Parathyroid gland; glandular cells[≥Low]	Parathyroid gland; glandular cells[≥Low]	99	4.540046e-07	2
HPA	HPA:0360000	Parathyroid gland	Parathyroid gland	99	4.540046e-07	2
HPA	HPA:0440343	Skeletal muscle; myocytes[High]	Skeletal muscle; myocytes[High]	32	4.900731e-07	2
HPA	HPA:0550000	Stomach 2	Stomach 2	114	6.025377e-07	2
HPA	HPA:0550051	Stomach 2; glandular cells[≥Low]	Stomach 2; glandular cells[≥Low]	114	6.025377e-07	2
HPA	HPA:0430052	Seminal vesicle; glandular cells[≥Medium]	Seminal vesicle; glandular cells[≥Medium]	92	6.097995e-07	2
HPA	HPA:0351181	Pancreas; pancreatic endocrine cells[≥Low]	Pancreas; pancreatic endocrine cells[≥Low]	96	6.367056e-07	2
HPA	HPA:0480000	Small intestine	Small intestine	116	6.636267e-07	2
HPA	HPA:0460203	Skin 1; endothelial cells[High]	Skin 1; endothelial cells[High]	19	6.748559e-07	2
HPA	HPA:0471461	Skin 2; langerhans cells[≥Low]	Skin 2; langerhans cells[≥Low]	30	6.833124e-07	2
HPA	HPA:0471472	Skin 2; lymphocytes[≥Medium]	Skin 2; lymphocytes[≥Medium]	27	6.921789e-07	2
HPA	HPA:0310433	Lymph node; germinal center cells[High]	Lymph node; germinal center cells[High]	33	7.379054e-07	2
HPA	HPA:0570773	Testis; peritubular cells[High]	Testis; peritubular cells[High]	16	7.482257e-07	2
HPA	HPA:0470683	Skin 2; epidermal cells[High]	Skin 2; epidermal cells[High]	35	7.672055e-07	2
HPA	HPA:0461473	Skin 1; lymphocytes[High]	Skin 1; lymphocytes[High]	21	7.877746e-07	2
HPA	HPA:0150000	Duodenum	Duodenum	116	8.651946e-07	2
HPA	HPA:0300201	Lung; endothelial cells[≥Low]	Lung; endothelial cells[≥Low]	30	9.186660e-07	2
HPA	HPA:0471471	Skin 2; lymphocytes[≥Low]	Skin 2; lymphocytes[≥Low]	30	1.002990e-06	2
HPA	HPA:0160051	Endometrium 1; glandular cells[≥Low]	Endometrium 1; glandular cells[≥Low]	107	1.065097e-06	2
HPA	HPA:0100131	Cerebral cortex; neuronal cells[≥Low]	Cerebral cortex; neuronal cells[≥Low]	106	1.093821e-06	2
HPA	HPA:0020051	Adrenal gland; glandular cells[≥Low]	Adrenal gland; glandular cells[≥Low]	112	1.154306e-06	2
HPA	HPA:0160000	Endometrium 1	Endometrium 1	109	1.187021e-06	2
HPA	HPA:0301372	Lung; alveolar cells type II[≥Medium]	Lung; alveolar cells type II[≥Medium]	38	1.195836e-06	2
HPA	HPA:0020000	Adrenal gland	Adrenal gland	112	1.253222e-06	2
HPA	HPA:0461471	Skin 1; lymphocytes[≥Low]	Skin 1; lymphocytes[≥Low]	28	1.284430e-06	2
HPA	HPA:0490693	Smooth muscle; smooth muscle cells[High]	Smooth muscle; smooth muscle cells[High]	26	1.348121e-06	2
HPA	HPA:0461443	Skin 1; fibrohistiocytic cells[High]	Skin 1; fibrohistiocytic cells[High]	21	1.404515e-06	2
HPA	HPA:0471393	Skin 2; cells in basal layer[High]	Skin 2; cells in basal layer[High]	18	1.547000e-06	2
HPA	HPA:0470671	Skin 2; melanocytes[≥Low]	Skin 2; melanocytes[≥Low]	28	1.801119e-06	2
HPA	HPA:0471473	Skin 2; lymphocytes[High]	Skin 2; lymphocytes[High]	22	1.914613e-06	2
HPA	HPA:0030072	Appendix; lymphoid tissue[≥Medium]	Appendix; lymphoid tissue[≥Medium]	64	2.321144e-06	2
HPA	HPA:0471442	Skin 2; fibrohistiocytic cells[≥Medium]	Skin 2; fibrohistiocytic cells[≥Medium]	30	2.423231e-06	2
HPA	HPA:0600443	Tonsil; non-germinal center cells[High]	Tonsil; non-germinal center cells[High]	39	2.501908e-06	2
HPA	HPA:0030053	Appendix; glandular cells[High]	Appendix; glandular cells[High]	48	2.623236e-06	2
HPA	HPA:0301362	Lung; alveolar cells type I[≥Medium]	Lung; alveolar cells type I[≥Medium]	31	2.624096e-06	2
HPA	HPA:0050011	Breast; adipocytes[≥Low]	Breast; adipocytes[≥Low]	61	2.700321e-06	2
HPA	HPA:0290401	Liver; hepatocytes[≥Low]	Liver; hepatocytes[≥Low]	96	2.733695e-06	2
HPA	HPA:0250123	Hippocampus; glial cells[High]	Hippocampus; glial cells[High]	24	2.998654e-06	2
HPA	HPA:0461413	Skin 1; cells in spinous layer[High]	Skin 1; cells in spinous layer[High]	15	3.071999e-06	2
HPA	HPA:0080131	Caudate; neuronal cells[≥Low]	Caudate; neuronal cells[≥Low]	100	3.169756e-06	2
HPA	HPA:0470000	Skin 2	Skin 2	108	3.411028e-06	2
HPA	HPA:0570763	Testis; pachytene spermatocytes[High]	Testis; pachytene spermatocytes[High]	32	3.473442e-06	2
HPA	HPA:0461442	Skin 1; fibrohistiocytic cells[≥Medium]	Skin 1; fibrohistiocytic cells[≥Medium]	27	3.638408e-06	2
HPA	HPA:0250121	Hippocampus; glial cells[≥Low]	Hippocampus; glial cells[≥Low]	78	4.078601e-06	2
HPA	HPA:0351183	Pancreas; pancreatic endocrine cells[High]	Pancreas; pancreatic endocrine cells[High]	29	4.273141e-06	2
HPA	HPA:0250000	Hippocampus	Hippocampus	106	4.278329e-06	2
HPA	HPA:0180052	Epididymis; glandular cells[≥Medium]	Epididymis; glandular cells[≥Medium]	95	4.306663e-06	2
HPA	HPA:0301371	Lung; alveolar cells type II[≥Low]	Lung; alveolar cells type II[≥Low]	42	4.591748e-06	2
HPA	HPA:0460183	Skin 1; cells in granular layer[High]	Skin 1; cells in granular layer[High]	16	5.076848e-06	2
HPA	HPA:0170253	Endometrium 2; cells in endometrial stroma[High]	Endometrium 2; cells in endometrial stroma[High]	19	5.202405e-06	2
HPA	HPA:0020052	Adrenal gland; glandular cells[≥Medium]	Adrenal gland; glandular cells[≥Medium]	98	5.947096e-06	2
HPA	HPA:0461472	Skin 1; lymphocytes[≥Medium]	Skin 1; lymphocytes[≥Medium]	24	6.158095e-06	2
HPA	HPA:0461463	Skin 1; langerhans cells[High]	Skin 1; langerhans cells[High]	15	6.178596e-06	2
HPA	HPA:0340000	Ovary	Ovary	92	6.399302e-06	2
HPA	HPA:0461462	Skin 1; langerhans cells[≥Medium]	Skin 1; langerhans cells[≥Medium]	24	6.805654e-06	2
HPA	HPA:0250122	Hippocampus; glial cells[≥Medium]	Hippocampus; glial cells[≥Medium]	49	7.135880e-06	2
HPA	HPA:0010000	Adipose tissue	Adipose tissue	75	7.149079e-06	2
HPA	HPA:0010011	Adipose tissue; adipocytes[≥Low]	Adipose tissue; adipocytes[≥Low]	75	7.149079e-06	2
HPA	HPA:0301361	Lung; alveolar cells type I[≥Low]	Lung; alveolar cells type I[≥Low]	34	7.605270e-06	2
HPA	HPA:0351182	Pancreas; pancreatic endocrine cells[≥Medium]	Pancreas; pancreatic endocrine cells[≥Medium]	71	8.049236e-06	2
HPA	HPA:0310443	Lymph node; non-germinal center cells[High]	Lymph node; non-germinal center cells[High]	36	8.891796e-06	2
HPA	HPA:0471492	Skin 2; vascular mural cells[≥Medium]	Skin 2; vascular mural cells[≥Medium]	14	9.020221e-06	2
HPA	HPA:0400652	Rectum; fibroblasts[≥Medium]	Rectum; fibroblasts[≥Medium]	11	9.406137e-06	2
HPA	HPA:0461493	Skin 1; vascular mural cells[High]	Skin 1; vascular mural cells[High]	12	1.021576e-05	2
HPA	HPA:0010013	Adipose tissue; adipocytes[High]	Adipose tissue; adipocytes[High]	21	1.146934e-05	2
HPA	HPA:0430053	Seminal vesicle; glandular cells[High]	Seminal vesicle; glandular cells[High]	40	1.475434e-05	2
HPA	HPA:0100122	Cerebral cortex; glial cells[≥Medium]	Cerebral cortex; glial cells[≥Medium]	58	1.538542e-05	2
HPA	HPA:0570783	Testis; preleptotene spermatocytes[High]	Testis; preleptotene spermatocytes[High]	27	1.678677e-05	2
HPA	HPA:0080000	Caudate	Caudate	106	1.919565e-05	2
HPA	HPA:0471441	Skin 2; fibrohistiocytic cells[≥Low]	Skin 2; fibrohistiocytic cells[≥Low]	32	1.925197e-05	2
HPA	HPA:0050013	Breast; adipocytes[High]	Breast; adipocytes[High]	17	1.944146e-05	2
HPA	HPA:0530712	Spleen; cells in red pulp[≥Medium]	Spleen; cells in red pulp[≥Medium]	64	1.967620e-05	2
HPA	HPA:0050012	Breast; adipocytes[≥Medium]	Breast; adipocytes[≥Medium]	40	2.029729e-05	2
HPA	HPA:0090000	Cerebellum	Cerebellum	108	2.058832e-05	2
HPA	HPA:0060000	Bronchus	Bronchus	110	2.264708e-05	2
HPA	HPA:0590053	Thyroid gland; glandular cells[High]	Thyroid gland; glandular cells[High]	46	2.409663e-05	2
HPA	HPA:0400053	Rectum; glandular cells[High]	Rectum; glandular cells[High]	56	2.640789e-05	2
HPA	HPA:0180000	Epididymis	Epididymis	109	2.721604e-05	2
HPA	HPA:0180051	Epididymis; glandular cells[≥Low]	Epididymis; glandular cells[≥Low]	109	2.721604e-05	2
HPA	HPA:0390000	Prostate	Prostate	103	2.774909e-05	2
HPA	HPA:0390051	Prostate; glandular cells[≥Low]	Prostate; glandular cells[≥Low]	103	2.774909e-05	2
HPA	HPA:0090161	Cerebellum; Purkinje cells[≥Low]	Cerebellum; Purkinje cells[≥Low]	92	2.908162e-05	2
HPA	HPA:0100121	Cerebral cortex; glial cells[≥Low]	Cerebral cortex; glial cells[≥Low]	85	2.950896e-05	2
HPA	HPA:0470203	Skin 2; endothelial cells[High]	Skin 2; endothelial cells[High]	17	3.076971e-05	2
HPA	HPA:0380511	Placenta; decidual cells[≥Low]	Placenta; decidual cells[≥Low]	84	3.097737e-05	2
HPA	HPA:0400651	Rectum; fibroblasts[≥Low]	Rectum; fibroblasts[≥Low]	11	3.346290e-05	2
HPA	HPA:0461441	Skin 1; fibrohistiocytic cells[≥Low]	Skin 1; fibrohistiocytic cells[≥Low]	29	3.591256e-05	2
HPA	HPA:0630051	Cervix; glandular cells[≥Low]	Cervix; glandular cells[≥Low]	93	3.739689e-05	2
HPA	HPA:0080122	Caudate; glial cells[≥Medium]	Caudate; glial cells[≥Medium]	52	3.796376e-05	2
HPA	HPA:0460201	Skin 1; endothelial cells[≥Low]	Skin 1; endothelial cells[≥Low]	28	4.468939e-05	2
HPA	HPA:0050092	Breast; myoepithelial cells[≥Medium]	Breast; myoepithelial cells[≥Medium]	71	4.959352e-05	2
HPA	HPA:0461492	Skin 1; vascular mural cells[≥Medium]	Skin 1; vascular mural cells[≥Medium]	13	5.677306e-05	2
HPA	HPA:0380523	Placenta; trophoblastic cells[High]	Placenta; trophoblastic cells[High]	46	5.720391e-05	2
HPA	HPA:0471493	Skin 2; vascular mural cells[High]	Skin 2; vascular mural cells[High]	11	5.932707e-05	2
HPA	HPA:0270353	Kidney; cells in glomeruli[High]	Kidney; cells in glomeruli[High]	28	6.144116e-05	2
HPA	HPA:0130203	Colon; endothelial cells[High]	Colon; endothelial cells[High]	28	6.294633e-05	2
HPA	HPA:0510651	Soft tissue 2; fibroblasts[≥Low]	Soft tissue 2; fibroblasts[≥Low]	75	6.356642e-05	2
HPA	HPA:0570812	Testis; spermatogonia cells[≥Medium]	Testis; spermatogonia cells[≥Medium]	55	6.575330e-05	2
HPA	HPA:0220053	Gallbladder; glandular cells[High]	Gallbladder; glandular cells[High]	59	7.189876e-05	2
HPA	HPA:0380521	Placenta; trophoblastic cells[≥Low]	Placenta; trophoblastic cells[≥Low]	99	8.002232e-05	2
HPA	HPA:0570793	Testis; round or early spermatids[High]	Testis; round or early spermatids[High]	31	8.267179e-05	2
HPA	HPA:0471463	Skin 2; langerhans cells[High]	Skin 2; langerhans cells[High]	15	8.471564e-05	2
HPA	HPA:0010012	Adipose tissue; adipocytes[≥Medium]	Adipose tissue; adipocytes[≥Medium]	50	8.688145e-05	2
HPA	HPA:0290402	Liver; hepatocytes[≥Medium]	Liver; hepatocytes[≥Medium]	70	9.293815e-05	2
HPA	HPA:0380522	Placenta; trophoblastic cells[≥Medium]	Placenta; trophoblastic cells[≥Medium]	85	1.084809e-04	2
HPA	HPA:0130000	Colon	Colon	116	1.285952e-04	2
HPA	HPA:0300000	Lung	Lung	108	1.319702e-04	2
HPA	HPA:0470201	Skin 2; endothelial cells[≥Low]	Skin 2; endothelial cells[≥Low]	28	1.368519e-04	2
HPA	HPA:0471491	Skin 2; vascular mural cells[≥Low]	Skin 2; vascular mural cells[≥Low]	14	1.431740e-04	2
HPA	HPA:0490000	Smooth muscle	Smooth muscle	89	1.545982e-04	2
HPA	HPA:0490691	Smooth muscle; smooth muscle cells[≥Low]	Smooth muscle; smooth muscle cells[≥Low]	89	1.545982e-04	2
HPA	HPA:0470202	Skin 2; endothelial cells[≥Medium]	Skin 2; endothelial cells[≥Medium]	23	1.708955e-04	2
HPA	HPA:0570782	Testis; preleptotene spermatocytes[≥Medium]	Testis; preleptotene spermatocytes[≥Medium]	38	1.880591e-04	2
HPA	HPA:0460202	Skin 1; endothelial cells[≥Medium]	Skin 1; endothelial cells[≥Medium]	22	1.970272e-04	2
HPA	HPA:0500651	Soft tissue 1; fibroblasts[≥Low]	Soft tissue 1; fibroblasts[≥Low]	75	2.109103e-04	2
HPA	HPA:0460663	Skin 1; keratinocytes[High]	Skin 1; keratinocytes[High]	23	2.366317e-04	2
HPA	HPA:0300411	Lung; macrophages[≥Low]	Lung; macrophages[≥Low]	102	2.445602e-04	2
HPA	HPA:0150053	Duodenum; glandular cells[High]	Duodenum; glandular cells[High]	54	2.714142e-04	2
HPA	HPA:0100203	Cerebral cortex; endothelial cells[High]	Cerebral cortex; endothelial cells[High]	18	2.945939e-04	2
HPA	HPA:0570811	Testis; spermatogonia cells[≥Low]	Testis; spermatogonia cells[≥Low]	60	3.081632e-04	2
HPA	HPA:0590000	Thyroid gland	Thyroid gland	105	3.091434e-04	2
HPA	HPA:0590051	Thyroid gland; glandular cells[≥Low]	Thyroid gland; glandular cells[≥Low]	105	3.091434e-04	2
HPA	HPA:0290000	Liver	Liver	97	3.180234e-04	2
HPA	HPA:0510652	Soft tissue 2; fibroblasts[≥Medium]	Soft tissue 2; fibroblasts[≥Medium]	54	3.202203e-04	2
HPA	HPA:0390053	Prostate; glandular cells[High]	Prostate; glandular cells[High]	35	3.211457e-04	2
HPA	HPA:0030073	Appendix; lymphoid tissue[High]	Appendix; lymphoid tissue[High]	25	3.377614e-04	2
HPA	HPA:0270362	Kidney; cells in tubules[≥Medium]	Kidney; cells in tubules[≥Medium]	92	3.793137e-04	2
HPA	HPA:0030000	Appendix	Appendix	111	4.189709e-04	2
HPA	HPA:0400892	Rectum; goblet cells[≥Medium]	Rectum; goblet cells[≥Medium]	16	4.235891e-04	2
HPA	HPA:0401302	Rectum; enterocytes[≥Medium]	Rectum; enterocytes[≥Medium]	17	4.449295e-04	2
HPA	HPA:0570771	Testis; peritubular cells[≥Low]	Testis; peritubular cells[≥Low]	24	4.460424e-04	2
HPA	HPA:0461393	Skin 1; cells in basal layer[High]	Skin 1; cells in basal layer[High]	12	4.469961e-04	2
HPA	HPA:0570772	Testis; peritubular cells[≥Medium]	Testis; peritubular cells[≥Medium]	20	4.737606e-04	2
HPA	HPA:0050091	Breast; myoepithelial cells[≥Low]	Breast; myoepithelial cells[≥Low]	90	4.922964e-04	2
HPA	HPA:0530723	Spleen; cells in white pulp[High]	Spleen; cells in white pulp[High]	26	6.721036e-04	2
HPA	HPA:0401332	Rectum; mucosal lymphoid cells[≥Medium]	Rectum; mucosal lymphoid cells[≥Medium]	17	6.743477e-04	2
HPA	HPA:0130651	Colon; fibroblasts[≥Low]	Colon; fibroblasts[≥Low]	9	8.120580e-04	2
HPA	HPA:0630052	Cervix; glandular cells[≥Medium]	Cervix; glandular cells[≥Medium]	71	8.819108e-04	2
HPA	HPA:0100201	Cerebral cortex; endothelial cells[≥Low]	Cerebral cortex; endothelial cells[≥Low]	78	8.822039e-04	2
HPA	HPA:0500703	Soft tissue 1; peripheral nerve[High]	Soft tissue 1; peripheral nerve[High]	13	8.922759e-04	2
HPA	HPA:0270351	Kidney; cells in glomeruli[≥Low]	Kidney; cells in glomeruli[≥Low]	84	9.061400e-04	2
HPA	HPA:0461491	Skin 1; vascular mural cells[≥Low]	Skin 1; vascular mural cells[≥Low]	13	9.339436e-04	2
HPA	HPA:0291163	Liver; cholangiocytes[High]	Liver; cholangiocytes[High]	15	9.359332e-04	2
HPA	HPA:0030071	Appendix; lymphoid tissue[≥Low]	Appendix; lymphoid tissue[≥Low]	79	1.010867e-03	2
HPA	HPA:0570813	Testis; spermatogonia cells[High]	Testis; spermatogonia cells[High]	36	1.044988e-03	2
HPA	HPA:0320102	Nasopharynx; respiratory epithelial cells[≥Medium]	Nasopharynx; respiratory epithelial cells[≥Medium]	79	1.135866e-03	2
HPA	HPA:0471413	Skin 2; cells in spinous layer[High]	Skin 2; cells in spinous layer[High]	13	1.222214e-03	2
HPA	HPA:0471443	Skin 2; fibrohistiocytic cells[High]	Skin 2; fibrohistiocytic cells[High]	18	1.327276e-03	2
HPA	HPA:0320101	Nasopharynx; respiratory epithelial cells[≥Low]	Nasopharynx; respiratory epithelial cells[≥Low]	90	1.348066e-03	2
HPA	HPA:0210052	Fallopian tube; glandular cells[≥Medium]	Fallopian tube; glandular cells[≥Medium]	78	1.354822e-03	2
HPA	HPA:0360053	Parathyroid gland; glandular cells[High]	Parathyroid gland; glandular cells[High]	37	1.379241e-03	2
HPA	HPA:0461452	Skin 1; hair follicles[≥Medium]	Skin 1; hair follicles[≥Medium]	14	1.512732e-03	2
HPA	HPA:0130892	Colon; goblet cells[≥Medium]	Colon; goblet cells[≥Medium]	15	1.572053e-03	2
HPA	HPA:0590052	Thyroid gland; glandular cells[≥Medium]	Thyroid gland; glandular cells[≥Medium]	88	1.628645e-03	2
HPA	HPA:0270000	Kidney	Kidney	113	2.060063e-03	2
HPA	HPA:0400052	Rectum; glandular cells[≥Medium]	Rectum; glandular cells[≥Medium]	93	2.166051e-03	2
HPA	HPA:0210051	Fallopian tube; glandular cells[≥Low]	Fallopian tube; glandular cells[≥Low]	89	2.585673e-03	2
HPA	HPA:0570000	Testis	Testis	119	2.623129e-03	2
HPA	HPA:0080121	Caudate; glial cells[≥Low]	Caudate; glial cells[≥Low]	76	2.772165e-03	2
HPA	HPA:0510000	Soft tissue 2	Soft tissue 2	83	2.950776e-03	2
HPA	HPA:0400242	Rectum; peripheral nerve/ganglion[≥Medium]	Rectum; peripheral nerve/ganglion[≥Medium]	11	2.984468e-03	2
HPA	HPA:0090183	Cerebellum; cells in granular layer[High]	Cerebellum; cells in granular layer[High]	23	3.089267e-03	2
HPA	HPA:0470673	Skin 2; melanocytes[High]	Skin 2; melanocytes[High]	15	3.147152e-03	2
HPA	HPA:0510702	Soft tissue 2; peripheral nerve[≥Medium]	Soft tissue 2; peripheral nerve[≥Medium]	36	3.272773e-03	2
HPA	HPA:0130201	Colon; endothelial cells[≥Low]	Colon; endothelial cells[≥Low]	88	3.280822e-03	2
HPA	HPA:0030892	Appendix; goblet cells[≥Medium]	Appendix; goblet cells[≥Medium]	14	3.331386e-03	2
HPA	HPA:0570803	Testis; sertoli cells[High]	Testis; sertoli cells[High]	20	3.596525e-03	2
HPA	HPA:0030052	Appendix; glandular cells[≥Medium]	Appendix; glandular cells[≥Medium]	86	3.624997e-03	2
HPA	HPA:0530713	Spleen; cells in red pulp[High]	Spleen; cells in red pulp[High]	24	3.854790e-03	2
HPA	HPA:0400891	Rectum; goblet cells[≥Low]	Rectum; goblet cells[≥Low]	16	4.117500e-03	2
HPA	HPA:0500113	Soft tissue 1; chondrocytes[High]	Soft tissue 1; chondrocytes[High]	14	4.269679e-03	2
HPA	HPA:0131332	Colon; mucosal lymphoid cells[≥Medium]	Colon; mucosal lymphoid cells[≥Medium]	15	4.369534e-03	2
HPA	HPA:0130891	Colon; goblet cells[≥Low]	Colon; goblet cells[≥Low]	16	4.373018e-03	2
HPA	HPA:0570781	Testis; preleptotene spermatocytes[≥Low]	Testis; preleptotene spermatocytes[≥Low]	41	4.414130e-03	2
HPA	HPA:0461451	Skin 1; hair follicles[≥Low]	Skin 1; hair follicles[≥Low]	15	4.512356e-03	2
HPA	HPA:0570791	Testis; round or early spermatids[≥Low]	Testis; round or early spermatids[≥Low]	47	4.535967e-03	2
HPA	HPA:0461482	Skin 1; sebaceous glands[≥Medium]	Skin 1; sebaceous glands[≥Medium]	10	4.671371e-03	2
HPA	HPA:0480053	Small intestine; glandular cells[High]	Small intestine; glandular cells[High]	50	4.706976e-03	2
HPA	HPA:0130202	Colon; endothelial cells[≥Medium]	Colon; endothelial cells[≥Medium]	65	4.768517e-03	2
HPA	HPA:0500111	Soft tissue 1; chondrocytes[≥Low]	Soft tissue 1; chondrocytes[≥Low]	45	4.770619e-03	2
HPA	HPA:0060101	Bronchus; respiratory epithelial cells[≥Low]	Bronchus; respiratory epithelial cells[≥Low]	90	4.938486e-03	2
HPA	HPA:0180053	Epididymis; glandular cells[High]	Epididymis; glandular cells[High]	40	5.063700e-03	2
HPA	HPA:0570792	Testis; round or early spermatids[≥Medium]	Testis; round or early spermatids[≥Medium]	41	5.151957e-03	2
HPA	HPA:0400203	Rectum; endothelial cells[High]	Rectum; endothelial cells[High]	8	5.264139e-03	2
HPA	HPA:0130053	Colon; glandular cells[High]	Colon; glandular cells[High]	48	5.557152e-03	2
HPA	HPA:0100000	Cerebral cortex	Cerebral cortex	111	5.713249e-03	2
HPA	HPA:0570732	Testis; Leydig cells[≥Medium]	Testis; Leydig cells[≥Medium]	84	5.737308e-03	2
HPA	HPA:0270361	Kidney; cells in tubules[≥Low]	Kidney; cells in tubules[≥Low]	101	5.992588e-03	2
HPA	HPA:0381192	Placenta; cytotrophoblasts[≥Medium]	Placenta; cytotrophoblasts[≥Medium]	16	6.225075e-03	2
HPA	HPA:0340463	Ovary; ovarian stroma cells[High]	Ovary; ovarian stroma cells[High]	15	6.379512e-03	2
HPA	HPA:0470183	Skin 2; cells in granular layer[High]	Skin 2; cells in granular layer[High]	12	6.456422e-03	2
HPA	HPA:0131302	Colon; enterocytes[≥Medium]	Colon; enterocytes[≥Medium]	15	6.784266e-03	2
HPA	HPA:0570761	Testis; pachytene spermatocytes[≥Low]	Testis; pachytene spermatocytes[≥Low]	47	7.126154e-03	2
HPA	HPA:0151352	Duodenum; paneth cells[≥Medium]	Duodenum; paneth cells[≥Medium]	12	7.561878e-03	2
HPA	HPA:0400201	Rectum; endothelial cells[≥Low]	Rectum; endothelial cells[≥Low]	12	8.173926e-03	2
HPA	HPA:0401333	Rectum; mucosal lymphoid cells[High]	Rectum; mucosal lymphoid cells[High]	10	8.568581e-03	2
HPA	HPA:0400051	Rectum; glandular cells[≥Low]	Rectum; glandular cells[≥Low]	101	8.695341e-03	2
HPA	HPA:0481351	Small intestine; paneth cells[≥Low]	Small intestine; paneth cells[≥Low]	12	1.027610e-02	2
HPA	HPA:0570762	Testis; pachytene spermatocytes[≥Medium]	Testis; pachytene spermatocytes[≥Medium]	40	1.043994e-02	2
HPA	HPA:0030442	Appendix; non-germinal center cells[≥Medium]	Appendix; non-germinal center cells[≥Medium]	12	1.107413e-02	2
HPA	HPA:0130653	Colon; fibroblasts[High]	Colon; fibroblasts[High]	6	1.137771e-02	2
HPA	HPA:0460642	Skin 1; Langerhans[≥Medium]	Skin 1; Langerhans[≥Medium]	50	1.178081e-02	2
HPA	HPA:0400202	Rectum; endothelial cells[≥Medium]	Rectum; endothelial cells[≥Medium]	10	1.249309e-02	2
HPA	HPA:0131292	Colon; endocrine cells[≥Medium]	Colon; endocrine cells[≥Medium]	15	1.261958e-02	2
HPA	HPA:0360052	Parathyroid gland; glandular cells[≥Medium]	Parathyroid gland; glandular cells[≥Medium]	72	1.325235e-02	2
HPA	HPA:0481352	Small intestine; paneth cells[≥Medium]	Small intestine; paneth cells[≥Medium]	11	1.354613e-02	2
HPA	HPA:0401303	Rectum; enterocytes[High]	Rectum; enterocytes[High]	11	1.410042e-02	2
HPA	HPA:0241101	Heart muscle; cardiomyocytes[≥Low]	Heart muscle; cardiomyocytes[≥Low]	93	1.480491e-02	2
HPA	HPA:0240000	Heart muscle	Heart muscle	93	1.480491e-02	2
HPA	HPA:0031302	Appendix; enterocytes[≥Medium]	Appendix; enterocytes[≥Medium]	14	1.603188e-02	2
HPA	HPA:0490692	Smooth muscle; smooth muscle cells[≥Medium]	Smooth muscle; smooth muscle cells[≥Medium]	56	1.654955e-02	2
HPA	HPA:0460662	Skin 1; keratinocytes[≥Medium]	Skin 1; keratinocytes[≥Medium]	58	1.689009e-02	2
HPA	HPA:0401301	Rectum; enterocytes[≥Low]	Rectum; enterocytes[≥Low]	17	1.761356e-02	2
HPA	HPA:0461453	Skin 1; hair follicles[High]	Skin 1; hair follicles[High]	8	1.912907e-02	2
HPA	HPA:0031292	Appendix; endocrine cells[≥Medium]	Appendix; endocrine cells[≥Medium]	14	1.913306e-02	2
HPA	HPA:0151351	Duodenum; paneth cells[≥Low]	Duodenum; paneth cells[≥Low]	12	1.964017e-02	2
HPA	HPA:0400653	Rectum; fibroblasts[High]	Rectum; fibroblasts[High]	6	2.015189e-02	2
HPA	HPA:0381203	Placenta; hofbauer cells[High]	Placenta; hofbauer cells[High]	12	2.251432e-02	2
HPA	HPA:0270352	Kidney; cells in glomeruli[≥Medium]	Kidney; cells in glomeruli[≥Medium]	55	2.448793e-02	2
HPA	HPA:0381191	Placenta; cytotrophoblasts[≥Low]	Placenta; cytotrophoblasts[≥Low]	16	2.487168e-02	2
HPA	HPA:0500000	Soft tissue 1	Soft tissue 1	82	2.530684e-02	2
HPA	HPA:0151302	Duodenum; enterocytes[≥Medium]	Duodenum; enterocytes[≥Medium]	15	2.565797e-02	2
HPA	HPA:0461481	Skin 1; sebaceous glands[≥Low]	Skin 1; sebaceous glands[≥Low]	10	2.613304e-02	2
HPA	HPA:0241103	Heart muscle; cardiomyocytes[High]	Heart muscle; cardiomyocytes[High]	28	2.703443e-02	2
HPA	HPA:0100202	Cerebral cortex; endothelial cells[≥Medium]	Cerebral cortex; endothelial cells[≥Medium]	47	2.758423e-02	2
HPA	HPA:0381202	Placenta; hofbauer cells[≥Medium]	Placenta; hofbauer cells[≥Medium]	14	2.770128e-02	2
HPA	HPA:0130652	Colon; fibroblasts[≥Medium]	Colon; fibroblasts[≥Medium]	7	2.814432e-02	2
HPA	HPA:0150892	Duodenum; goblet cells[≥Medium]	Duodenum; goblet cells[≥Medium]	13	2.879828e-02	2
HPA	HPA:0030441	Appendix; non-germinal center cells[≥Low]	Appendix; non-germinal center cells[≥Low]	13	2.879828e-02	2
HPA	HPA:0150051	Duodenum; glandular cells[≥Low]	Duodenum; glandular cells[≥Low]	100	2.911132e-02	2
HPA	HPA:0030891	Appendix; goblet cells[≥Low]	Appendix; goblet cells[≥Low]	14	3.093497e-02	2
HPA	HPA:0211092	Fallopian tube; non-ciliated cells[≥Medium]	Fallopian tube; non-ciliated cells[≥Medium]	18	3.187075e-02	2
HPA	HPA:0381201	Placenta; hofbauer cells[≥Low]	Placenta; hofbauer cells[≥Low]	15	3.235190e-02	2
HPA	HPA:0020053	Adrenal gland; glandular cells[High]	Adrenal gland; glandular cells[High]	44	3.262306e-02	2
HPA	HPA:0480892	Small intestine; goblet cells[≥Medium]	Small intestine; goblet cells[≥Medium]	13	3.439024e-02	2
HPA	HPA:0381193	Placenta; cytotrophoblasts[High]	Placenta; cytotrophoblasts[High]	12	3.450247e-02	2
HPA	HPA:0401331	Rectum; mucosal lymphoid cells[≥Low]	Rectum; mucosal lymphoid cells[≥Low]	17	3.605672e-02	2
HPA	HPA:0481302	Small intestine; enterocytes[≥Medium]	Small intestine; enterocytes[≥Medium]	15	3.669285e-02	2
HPA	HPA:0400893	Rectum; goblet cells[High]	Rectum; goblet cells[High]	10	3.893190e-02	2
HPA	HPA:0131291	Colon; endocrine cells[≥Low]	Colon; endocrine cells[≥Low]	15	4.052299e-02	2
HPA	HPA:0030051	Appendix; glandular cells[≥Low]	Appendix; glandular cells[≥Low]	96	4.153538e-02	2
HPA	HPA:0300412	Lung; macrophages[≥Medium]	Lung; macrophages[≥Medium]	76	4.238570e-02	2
HPA	HPA:0130052	Colon; glandular cells[≥Medium]	Colon; glandular cells[≥Medium]	88	4.288418e-02	2
HPA	HPA:0131303	Colon; enterocytes[High]	Colon; enterocytes[High]	10	4.709979e-02	2
HPA	HPA:0400241	Rectum; peripheral nerve/ganglion[≥Low]	Rectum; peripheral nerve/ganglion[≥Low]	11	4.724019e-02	2
HPA	HPA:0060102	Bronchus; respiratory epithelial cells[≥Medium]	Bronchus; respiratory epithelial cells[≥Medium]	76	4.849177e-02	2
HPA	HPA:0131301	Colon; enterocytes[≥Low]	Colon; enterocytes[≥Low]	16	4.925531e-02	2

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-615-3p	hsa-mir-615-3p	hsa-mir-615-3p	42	6.367541e-17	2
MIRNA	MIRNA:hsa-mir-92a-3p	hsa-mir-92a-3p	hsa-mir-92a-3p	38	5.427229e-09	2
MIRNA	MIRNA:hsa-mir-16-5p	hsa-mir-16-5p	hsa-mir-16-5p	40	1.425739e-08	2
MIRNA	MIRNA:hsa-mir-1296-5p	hsa-mir-1296-5p	hsa-mir-1296-5p	10	3.526892e-05	2
MIRNA	MIRNA:hsa-mir-744-5p	hsa-mir-744-5p	hsa-mir-744-5p	16	1.780175e-04	2
MIRNA	MIRNA:hsa-mir-877-3p	hsa-mir-877-3p	hsa-mir-877-3p	19	3.140086e-04	2
MIRNA	MIRNA:hsa-mir-193b-3p	hsa-mir-193b-3p	hsa-mir-193b-3p	22	9.389168e-04	2
MIRNA	MIRNA:hsa-let-7c-3p	hsa-let-7c-3p	hsa-let-7c-3p	8	9.479920e-04	2
MIRNA	MIRNA:hsa-mir-320a	hsa-mir-320a	hsa-mir-320a	33	3.403168e-03	2
MIRNA	MIRNA:hsa-mir-15b-5p	hsa-mir-15b-5p	hsa-mir-15b-5p	19	9.816458e-03	2
MIRNA	MIRNA:hsa-mir-505-3p	hsa-mir-505-3p	hsa-mir-505-3p	10	1.000833e-02	2
MIRNA	MIRNA:hsa-mir-652-3p	hsa-mir-652-3p	hsa-mir-652-3p	8	1.090480e-02	2
MIRNA	MIRNA:hsa-mir-149-5p	hsa-mir-149-5p	hsa-mir-149-5p	13	1.558902e-02	2
MIRNA	MIRNA:hsa-mir-92b-3p	hsa-mir-92b-3p	hsa-mir-92b-3p	17	1.767277e-02	2
MIRNA	MIRNA:hsa-mir-6729-5p	hsa-mir-6729-5p	hsa-mir-6729-5p	6	1.983651e-02	2
MIRNA	MIRNA:hsa-mir-524-5p	hsa-mir-524-5p	hsa-mir-524-5p	36	2.954132e-02	2
MIRNA	MIRNA:hsa-mir-520d-5p	hsa-mir-520d-5p	hsa-mir-520d-5p	36	2.984146e-02	2
MIRNA	MIRNA:hsa-mir-100-5p	hsa-mir-100-5p	hsa-mir-100-5p	10	3.445859e-02	2
MIRNA	MIRNA:hsa-mir-191-5p	hsa-mir-191-5p	hsa-mir-191-5p	6	3.506477e-02	2
MIRNA	MIRNA:hsa-mir-1273d	hsa-mir-1273d	hsa-mir-1273d	16	4.557075e-02	2

HP

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0002669	Osteosarcoma	A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor.	10	1.385437e-09	2
HP	HP:0002863	Myelodysplasia	Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.	13	4.254601e-08	2
HP	HP:0004808	Acute myeloid leukemia	A form of leukemia characterized by overproduction of an early myeloid cell.	11	1.375573e-07	2
HP	HP:0012133	Erythroid hypoplasia	Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.	8	4.803033e-07	2
HP	HP:0002488	Acute leukemia	A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).	12	1.316314e-06	2
HP	HP:0012131	Abnormal number of erythroid precursors	A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.	9	1.605081e-06	2
HP	HP:0011904	Persistence of hemoglobin F	Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent.	8	2.248507e-06	2
HP	HP:0001895	Normochromic anemia	Normochromic anemia	8	3.530424e-06	2
HP	HP:0031640	Abnormal radial artery morphology	Any structural anomaly of the radial artery.	7	4.861886e-06	2
HP	HP:0030270	Elevated red cell adenosine deaminase activity	Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine.	7	4.861886e-06	2
HP	HP:0020118	Radial artery aplasia	Congenital absence of the radial artery.	7	4.861886e-06	2
HP	HP:4000209	Abnormal erythrocyte adenosine deaminase activity	Activity of adenosine deaminase in red blood cells outside the limits of normal.	7	6.514815e-06	2
HP	HP:0001909	Leukemia	A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.	13	8.562434e-06	2
HP	HP:0005532	Macrocytic dyserythropoietic anemia	Macrocytic dyserythropoietic anemia	7	8.621925e-06	2
HP	HP:0001894	Thrombocytosis	Increased numbers of platelets in the peripheral blood.	9	1.457116e-05	2
HP	HP:0012410	Pure red cell aplasia	A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction.	7	1.460492e-05	2
HP	HP:0001227	Abnormality of the thenar eminence	An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb.	7	4.647703e-05	2
HP	HP:0040276	Adenocarcinoma of the colon	Adenocarcinoma of the colon	7	4.647703e-05	2
HP	HP:0000912	Sprengel anomaly	A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other).	8	5.342365e-05	2
HP	HP:0006758	Malignant genitourinary tract tumor	The presence of a malignant neoplasm of the genital system.	7	5.726707e-05	2
HP	HP:0011902	Abnormal hemoglobin	Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes.	9	5.857472e-05	2
HP	HP:0100242	Sarcoma	A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant.	12	6.923952e-05	2
HP	HP:0010622	Neoplasm of the skeletal system	A tumor (abnormal growth of tissue) of the skeleton.	10	7.008294e-05	2
HP	HP:0001896	Reticulocytopenia	A reduced number of reticulocytes in the peripheral blood.	7	7.010474e-05	2
HP	HP:0009777	Absent thumb	Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues.	8	9.554282e-05	2
HP	HP:0004377	Hematological neoplasm	Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue).	15	1.006985e-04	2
HP	HP:0040275	Adenocarcinoma of the large intestine	A malignant epithelial tumor with a glandular organization that originates in the large intestine.	7	1.031828e-04	2
HP	HP:0000185	Cleft soft palate	Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency.	8	1.256563e-04	2
HP	HP:0009944	Partial duplication of thumb phalanx	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	7	1.769796e-04	2
HP	HP:0040273	Adenocarcinoma of the intestines	A malignant epithelial tumor with a glandular organization that originates in the intestines.	7	2.098216e-04	2
HP	HP:0001874	Abnormality of neutrophils	A neutrophil abnormality.	14	2.189188e-04	2
HP	HP:0009999	Partial duplication of the phalanx of hand	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	7	2.476635e-04	2
HP	HP:0001911	Abnormal granulocyte morphology	Any structural abnormality or abnormal count of granulocytes.	15	2.625626e-04	2
HP	HP:0009380	Finger aplasia	A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers).	9	2.824699e-04	2
HP	HP:0030272	Abnormal erythrocyte enzyme concentration or activity	An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme.	7	5.348447e-04	2
HP	HP:0001972	Macrocytic anemia	A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).	8	6.671179e-04	2
HP	HP:0010974	Abnormal myeloid leukocyte morphology	An abnormality of myeloid leukocytes.	15	7.672048e-04	2
HP	HP:0001875	Decreased total neutrophil count	Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group.	12	7.701661e-04	2
HP	HP:0008772	Aplasia/Hypoplasia of the external ear	The presence of aplasia or developmental hypoplasia of all or part of the external ear.	12	7.701661e-04	2
HP	HP:0005518	Increased mean corpuscular volume	Larger than normal size of erythrocytes.	7	8.145479e-04	2
HP	HP:0011893	Abnormal leukocyte count	Number of leukocytes per volume of blood beyond normal limits.	18	9.629036e-04	2
HP	HP:0008771	Aplasia/Hypoplasia of the ear	The presence of aplasia or developmental hypoplasia of the ear.	12	1.099459e-03	2
HP	HP:0001881	Abnormal leukocyte morphology	An abnormality of leukocytes.	20	1.285669e-03	2
HP	HP:0010987	Abnormal cellular immune system morphology	An abnormality of the morphology or counts of the cells that make up the immune system.	20	1.285669e-03	2
HP	HP:0100273	Neoplasm of the colon	Neoplasm of the colon	8	1.486592e-03	2
HP	HP:0032309	Abnormal granulocyte count	Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group.	13	1.873473e-03	2
HP	HP:0011991	Abnormal total neutrophil count	A deviation from the normal range of neutrophil cell counts in the circulation.	12	1.963041e-03	2
HP	HP:0000294	Low anterior hairline	Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella.	10	2.046001e-03	2
HP	HP:0009942	Duplication of thumb phalanx	Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	7	2.215142e-03	2
HP	HP:0032251	Abnormal immune system morphology	Abnormal immune system morphology	20	2.508735e-03	2
HP	HP:0008551	Microtia	Underdevelopment of the external ear.	11	2.550991e-03	2
HP	HP:0025065	Abnormal mean corpuscular volume	A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters.	7	2.778964e-03	2
HP	HP:0100037	Abnormality of the scalp hair	An abnormality of the hair of head.	16	2.995998e-03	2
HP	HP:0009778	Short thumb	Hypoplasia (congenital reduction in size) of the thumb.	9	4.166345e-03	2
HP	HP:0001790	Nonimmune hydrops fetalis	A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens .	7	4.271187e-03	2
HP	HP:0001965	Abnormal scalp morphology	Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows.	16	4.981135e-03	2
HP	HP:0000316	Hypertelorism	Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes).	22	5.822825e-03	2
HP	HP:0001199	Triphalangeal thumb	A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb.	7	6.381086e-03	2
HP	HP:0011792	Neoplasm by histology	Neoplasm categorized according to type of histological abnormality.	14	7.216925e-03	2
HP	HP:0000599	Abnormality of the frontal hairline	An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not.	11	8.848550e-03	2
HP	HP:0006749	Malignant gastrointestinal tract tumors	Malignant gastrointestinal tract tumors	7	1.017801e-02	2
HP	HP:0001087	Developmental glaucoma	Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma.	7	1.017801e-02	2
HP	HP:0002672	Gastrointestinal carcinoma	Gastrointestinal carcinoma	7	1.017801e-02	2
HP	HP:0000519	Developmental cataract	A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens.	9	1.122651e-02	2
HP	HP:0100736	Abnormal soft palate morphology	An abnormality of the soft palate.	12	1.248549e-02	2
HP	HP:0011361	Congenital abnormal hair pattern	A congenital abnormality of the distribution of hair growth.	13	1.522978e-02	2
HP	HP:0009601	Aplasia/Hypoplasia of the thumb	Hypoplastic/small or absent thumb.	9	1.664215e-02	2
HP	HP:0000286	Epicanthus	A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus.	18	1.781809e-02	2
HP	HP:0000085	Horseshoe kidney	A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline.	9	1.854980e-02	2
HP	HP:0100834	Neoplasm of the large intestine	The presence of a neoplasm of the large intestine.	8	1.929984e-02	2
HP	HP:0004312	Abnormal reticulocyte morphology	A reticulocyte abnormality.	7	2.171585e-02	2
HP	HP:0000980	Pallor	Abnormally pale skin.	9	2.293198e-02	2
HP	HP:0001882	Decreased total leukocyte count	An abnormal decreased number of leukocytes in the blood.	9	2.817041e-02	2
HP	HP:0001671	Abnormal cardiac septum morphology	An anomaly of the intra-atrial or intraventricular septum.	20	3.020614e-02	2
HP	HP:0000465	Webbed neck	Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline.	8	3.359190e-02	2
HP	HP:0001421	Abnormality of the musculature of the hand	Abnormality of the musculature of the hand	8	4.234322e-02	2
HP	HP:0001595	Abnormal hair morphology	An abnormality of the hair.	27	4.895559e-02	2

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M00803	Factor: E2F; motif: GGCGSG	Factor: E2F; motif: GGCGSG	130	3.596420e-07	2
TF	TF:M04826_1	Factor: p300; motif: ACNTCCG; match class: 1	Factor: p300; motif: ACNTCCG; match class: 1	138	4.133513e-06	2
TF	TF:M10438_1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	136	1.045411e-05	2
TF	TF:M04691_1	Factor: Kaiso; motif: TCTCGCGAG; match class: 1	Factor: Kaiso; motif: TCTCGCGAG; match class: 1	111	1.235364e-05	2
TF	TF:M03977_1	Factor: ETS1; motif: ACCGGAARYN; match class: 1	Factor: ETS1; motif: ACCGGAARYN; match class: 1	66	1.805953e-05	2
TF	TF:M01660	Factor: GABP-alpha; motif: CTTCCK	Factor: GABP-alpha; motif: CTTCCK	114	2.836109e-05	2
TF	TF:M12600	Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN	Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN	97	4.736730e-05	2
TF	TF:M11435_1	Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1	Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1	74	6.087066e-05	2
TF	TF:M09905	Factor: SAP-1; motif: NNCCGGAAGTGN	Factor: SAP-1; motif: NNCCGGAAGTGN	94	6.331392e-05	2
TF	TF:M11435	Factor: Elk-1; motif: NNCCGGAAGTN	Factor: Elk-1; motif: NNCCGGAAGTN	117	7.450437e-05	2
TF	TF:M00025_1	Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1	Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1	62	1.002723e-04	2
TF	TF:M11527_1	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1	81	1.007311e-04	2
TF	TF:M12599_1	Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1	Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1	138	1.239062e-04	2
TF	TF:M02070	Factor: TEL1; motif: CNCGGAANNN	Factor: TEL1; motif: CNCGGAANNN	111	1.239528e-04	2
TF	TF:M11430	Factor: PEA3; motif: NACCGGAAGTN	Factor: PEA3; motif: NACCGGAAGTN	111	1.410133e-04	2
TF	TF:M00426_1	Factor: E2F; motif: TTTSGCGS; match class: 1	Factor: E2F; motif: TTTSGCGS; match class: 1	74	1.443654e-04	2
TF	TF:M04710	Factor: CHD2; motif: TCTCGCGAG	Factor: CHD2; motif: TCTCGCGAG	130	1.616923e-04	2
TF	TF:M02065_1	Factor: ER81; motif: RCCGGAARYN; match class: 1	Factor: ER81; motif: RCCGGAARYN; match class: 1	83	2.044843e-04	2
TF	TF:M11527	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN	82	2.136271e-04	2
TF	TF:M00740	Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC	Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC	108	2.242934e-04	2
TF	TF:M13031	Factor: ETV4; motif: ACCGGAAGTN	Factor: ETV4; motif: ACCGGAAGTN	110	2.331529e-04	2
TF	TF:M01078	Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN	Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN	87	2.346753e-04	2
TF	TF:M04714	Factor: Elf-1; motif: ACTTCCGGG	Factor: Elf-1; motif: ACTTCCGGG	89	2.354402e-04	2
TF	TF:M11400_1	Factor: Fli-1; motif: NACCGGAARTN; match class: 1	Factor: Fli-1; motif: NACCGGAARTN; match class: 1	59	2.439573e-04	2
TF	TF:M02052	Factor: EHF; motif: CSCGGAARTN	Factor: EHF; motif: CSCGGAARTN	105	2.807609e-04	2
TF	TF:M00940	Factor: E2F-1; motif: NTTTCGCGCS	Factor: E2F-1; motif: NTTTCGCGCS	89	2.918801e-04	2
TF	TF:M03967	Factor: ELF3; motif: WACCCGGAAGTAN	Factor: ELF3; motif: WACCCGGAAGTAN	87	2.955405e-04	2
TF	TF:M01660_1	Factor: GABP-alpha; motif: CTTCCK; match class: 1	Factor: GABP-alpha; motif: CTTCCK; match class: 1	67	3.126047e-04	2
TF	TF:M02065	Factor: ER81; motif: RCCGGAARYN	Factor: ER81; motif: RCCGGAARYN	122	3.583848e-04	2
TF	TF:M00425_1	Factor: E2F; motif: TTTCGCGC; match class: 1	Factor: E2F; motif: TTTCGCGC; match class: 1	69	3.586988e-04	2
TF	TF:M02071	Factor: ETV7; motif: NCCGGAANNN	Factor: ETV7; motif: NCCGGAANNN	105	4.281590e-04	2
TF	TF:M08526_1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	134	5.047927e-04	2
TF	TF:M12601	Factor: ELF4; motif: NCCACTTCCGGNNNN	Factor: ELF4; motif: NCCACTTCCGGNNNN	71	5.375786e-04	2
TF	TF:M11419	Factor: ER81; motif: NNCCGGAWGYN	Factor: ER81; motif: NNCCGGAWGYN	74	6.585730e-04	2
TF	TF:M11018_1	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1	138	6.826671e-04	2
TF	TF:M00940_1	Factor: E2F-1; motif: NTTTCGCGCS; match class: 1	Factor: E2F-1; motif: NTTTCGCGCS; match class: 1	43	6.854922e-04	2
TF	TF:M00050	Factor: E2F; motif: TTTSGCGC	Factor: E2F; motif: TTTSGCGC	82	7.647476e-04	2
TF	TF:M02068	Factor: etv3; motif: ACCGGAAGYN	Factor: etv3; motif: ACCGGAAGYN	51	7.706271e-04	2
TF	TF:M11447	Factor: Elf-1; motif: NAMCCGGAAGTN	Factor: Elf-1; motif: NAMCCGGAAGTN	87	7.721085e-04	2
TF	TF:M00333	Factor: ZF5; motif: NRNGNGCGCGCWN	Factor: ZF5; motif: NRNGNGCGCGCWN	134	8.521379e-04	2
TF	TF:M08377_1	Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1	Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1	65	9.591773e-04	2
TF	TF:M00426	Factor: E2F; motif: TTTSGCGS	Factor: E2F; motif: TTTSGCGS	116	9.736605e-04	2
TF	TF:M07380_1	Factor: E2F-4; motif: NTTTCSCGCC; match class: 1	Factor: E2F-4; motif: NTTTCSCGCC; match class: 1	89	1.116086e-03	2
TF	TF:M02069	Factor: Erm; motif: ACCGGAAGTN	Factor: Erm; motif: ACCGGAAGTN	80	1.225148e-03	2
TF	TF:M13032	Factor: ETV5; motif: ACCGGAAGTN	Factor: ETV5; motif: ACCGGAAGTN	99	1.236618e-03	2
TF	TF:M03962_1	Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT; match class: 1	Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT; match class: 1	77	1.314268e-03	2
TF	TF:M00025	Factor: Elk-1; motif: NNNNCCGGAARTNN	Factor: Elk-1; motif: NNNNCCGGAARTNN	103	1.361271e-03	2
TF	TF:M04744_1	Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1	Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1	63	1.432780e-03	2
TF	TF:M11392_1	Factor: Erg; motif: NACCGGAARYN; match class: 1	Factor: Erg; motif: NACCGGAARYN; match class: 1	48	1.490209e-03	2
TF	TF:M11450	Factor: Elf-1; motif: NANSCGGAAGTR	Factor: Elf-1; motif: NANSCGGAAGTR	69	1.846004e-03	2
TF	TF:M03983	Factor: ETV5; motif: NCCGGAWGYN	Factor: ETV5; motif: NCCGGAWGYN	47	1.934948e-03	2
TF	TF:M00737_1	Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1	Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1	45	2.032628e-03	2
TF	TF:M11415	Factor: GABP-alpha; motif: NRCCGGAAGTN	Factor: GABP-alpha; motif: NRCCGGAAGTN	48	2.043117e-03	2
TF	TF:M09901	Factor: nerf; motif: NNNCCGGAAGTGN	Factor: nerf; motif: NNNCCGGAAGTGN	67	2.044166e-03	2
TF	TF:M08526	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN	141	2.185605e-03	2
TF	TF:M00716	Factor: ZF5; motif: GSGCGCGR	Factor: ZF5; motif: GSGCGCGR	138	2.268626e-03	2
TF	TF:M11526_1	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1	78	2.519631e-03	2
TF	TF:M08913	Factor: FLI-1; motif: NAYTTCCGGT	Factor: FLI-1; motif: NAYTTCCGGT	90	2.753463e-03	2
TF	TF:M11451	Factor: Elf-1; motif: NANCCGGAAGTN	Factor: Elf-1; motif: NANCCGGAAGTN	79	3.103403e-03	2
TF	TF:M04691	Factor: Kaiso; motif: TCTCGCGAG	Factor: Kaiso; motif: TCTCGCGAG	133	3.183294e-03	2
TF	TF:M09966_1	Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1	Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1	15	3.258453e-03	2
TF	TF:M02062_1	Factor: Erg; motif: ACCGGAAGTN; match class: 1	Factor: Erg; motif: ACCGGAAGTN; match class: 1	42	3.389674e-03	2
TF	TF:M09606	Factor: nerf; motif: NRRNSCGGAAGNRNNNN	Factor: nerf; motif: NRRNSCGGAAGNRNNNN	74	3.457491e-03	2
TF	TF:M02067	Factor: ER71; motif: ACCGGAARYN	Factor: ER71; motif: ACCGGAARYN	71	3.474637e-03	2
TF	TF:M09894_1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	127	3.665642e-03	2
TF	TF:M11414	Factor: GABP-alpha; motif: NACCGGAAGTN	Factor: GABP-alpha; motif: NACCGGAAGTN	44	3.822486e-03	2
TF	TF:M13031_1	Factor: ETV4; motif: ACCGGAAGTN; match class: 1	Factor: ETV4; motif: ACCGGAAGTN; match class: 1	62	4.289759e-03	2
TF	TF:M03982	Factor: ETV4; motif: ACCGGAAGTN	Factor: ETV4; motif: ACCGGAAGTN	78	4.368799e-03	2
TF	TF:M13119	Factor: ZBTB11; motif: RCTTCCGGNNSNNNN	Factor: ZBTB11; motif: RCTTCCGGNNSNNNN	69	4.544323e-03	2
TF	TF:M03990	Factor: GABPA; motif: ACCGGAAGTN	Factor: GABPA; motif: ACCGGAAGTN	65	4.582646e-03	2
TF	TF:M00736_1	Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1	Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1	60	4.664019e-03	2
TF	TF:M11400	Factor: Fli-1; motif: NACCGGAARTN	Factor: Fli-1; motif: NACCGGAARTN	101	4.912942e-03	2
TF	TF:M00425	Factor: E2F; motif: TTTCGCGC	Factor: E2F; motif: TTTCGCGC	109	4.943848e-03	2
TF	TF:M10438	Factor: ZF5; motif: GGSGCGCGS	Factor: ZF5; motif: GGSGCGCGS	138	5.362720e-03	2
TF	TF:M11526	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN	80	5.538169e-03	2
TF	TF:M07380	Factor: E2F-4; motif: NTTTCSCGCC	Factor: E2F-4; motif: NTTTCSCGCC	121	5.681706e-03	2
TF	TF:M01770	Factor: XBP-1; motif: WNNGMCACGTC	Factor: XBP-1; motif: WNNGMCACGTC	108	5.721096e-03	2
TF	TF:M11882_1	Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1	Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1	111	6.213878e-03	2
TF	TF:M00803_1	Factor: E2F; motif: GGCGSG; match class: 1	Factor: E2F; motif: GGCGSG; match class: 1	103	6.319959e-03	2
TF	TF:M11396_1	Factor: Erg; motif: NACCGGAARTN; match class: 1	Factor: Erg; motif: NACCGGAARTN; match class: 1	62	6.568086e-03	2
TF	TF:M11452	Factor: Elf-1; motif: NANGCGGAAGTR	Factor: Elf-1; motif: NANGCGGAAGTR	73	6.982430e-03	2
TF	TF:M04810	Factor: USF2; motif: AAGTCACG	Factor: USF2; motif: AAGTCACG	73	7.027081e-03	2
TF	TF:M11428	Factor: PEA3; motif: NACCGGAAGTN	Factor: PEA3; motif: NACCGGAAGTN	80	7.120885e-03	2
TF	TF:M11427	Factor: PEA3; motif: NACCGGAAGTN	Factor: PEA3; motif: NACCGGAAGTN	105	7.212559e-03	2
TF	TF:M07415	Factor: Elf-1; motif: AWCCCGGAAGTN	Factor: Elf-1; motif: AWCCCGGAAGTN	86	7.876214e-03	2
TF	TF:M08982	Factor: YY1; motif: NAANATGGCGNNN	Factor: YY1; motif: NAANATGGCGNNN	79	8.457677e-03	2
TF	TF:M02066	Factor: PEA3; motif: RCCGGAAGYN	Factor: PEA3; motif: RCCGGAAGYN	79	8.457677e-03	2
TF	TF:M02070_1	Factor: TEL1; motif: CNCGGAANNN; match class: 1	Factor: TEL1; motif: CNCGGAANNN; match class: 1	61	8.621576e-03	2
TF	TF:M11434	Factor: Elk-1; motif: NRSCGGAAGNN	Factor: Elk-1; motif: NRSCGGAAGNN	88	8.737692e-03	2
TF	TF:M07250	Factor: E2F-1; motif: NNNSSCGCSAANN	Factor: E2F-1; motif: NNNSSCGCSAANN	106	8.982911e-03	2
TF	TF:M02063	Factor: c-ets-1; motif: ACCGGAWGTN	Factor: c-ets-1; motif: ACCGGAWGTN	83	9.158474e-03	2
TF	TF:M08205_1	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1	104	9.212946e-03	2
TF	TF:M11058_1	Factor: Hey1; motif: NGCRCGYGYN; match class: 1	Factor: Hey1; motif: NGCRCGYGYN; match class: 1	100	9.642427e-03	2
TF	TF:M11448	Factor: Elf-1; motif: NANGCGGAAGTN	Factor: Elf-1; motif: NANGCGGAAGTN	83	1.030664e-02	2
TF	TF:M11392	Factor: Erg; motif: NACCGGAARYN	Factor: Erg; motif: NACCGGAARYN	91	1.076668e-02	2
TF	TF:M03977	Factor: ETS1; motif: ACCGGAARYN	Factor: ETS1; motif: ACCGGAARYN	104	1.106202e-02	2
TF	TF:M11424	Factor: Erm; motif: NNSCGGAWGYN	Factor: Erm; motif: NNSCGGAWGYN	87	1.208071e-02	2
TF	TF:M08913_1	Factor: FLI-1; motif: NAYTTCCGGT; match class: 1	Factor: FLI-1; motif: NAYTTCCGGT; match class: 1	44	1.209508e-02	2
TF	TF:M02062	Factor: Erg; motif: ACCGGAAGTN	Factor: Erg; motif: ACCGGAAGTN	86	1.328513e-02	2
TF	TF:M08875	Factor: E2F; motif: NNTTTCGCGCN	Factor: E2F; motif: NNTTTCGCGCN	72	1.340647e-02	2
TF	TF:M11603_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	121	1.532191e-02	2
TF	TF:M00024_1	Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1	Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1	40	1.566486e-02	2
TF	TF:M02052_1	Factor: EHF; motif: CSCGGAARTN; match class: 1	Factor: EHF; motif: CSCGGAARTN; match class: 1	53	1.713458e-02	2
TF	TF:M02090_1	Factor: E2F-4; motif: GCGGGAAANA; match class: 1	Factor: E2F-4; motif: GCGGGAAANA; match class: 1	73	1.885461e-02	2
TF	TF:M11601	Factor: TCF-1; motif: ACATCGRGRCGCTGW	Factor: TCF-1; motif: ACATCGRGRCGCTGW	130	1.885493e-02	2
TF	TF:M02059_1	Factor: ELK-1; motif: ACCGGAAGTN; match class: 1	Factor: ELK-1; motif: ACCGGAAGTN; match class: 1	50	2.115604e-02	2
TF	TF:M12005_1	Factor: GMEB-1; motif: KNACGTNRNNACGTAN; match class: 1	Factor: GMEB-1; motif: KNACGTNRNNACGTAN; match class: 1	14	2.301338e-02	2
TF	TF:M00333_1	Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1	Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1	116	2.332899e-02	2
TF	TF:M01163	Factor: Elk-1; motif: AACCGGAAGTR	Factor: Elk-1; motif: AACCGGAAGTR	63	2.355139e-02	2
TF	TF:M11422	Factor: Erm; motif: NRCMGGAAGTN	Factor: Erm; motif: NRCMGGAAGTN	58	2.406472e-02	2
TF	TF:M00430_1	Factor: E2F-1; motif: NTTSGCGG; match class: 1	Factor: E2F-1; motif: NTTSGCGG; match class: 1	38	2.527208e-02	2
TF	TF:M08759_1	Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1	Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1	42	2.601954e-02	2
TF	TF:M00716_1	Factor: ZF5; motif: GSGCGCGR; match class: 1	Factor: ZF5; motif: GSGCGCGR; match class: 1	126	2.671075e-02	2
TF	TF:M08390_1	Factor: A-Myb:Elf-1; motif: NMCCGGAACCGTTA; match class: 1	Factor: A-Myb:Elf-1; motif: NMCCGGAACCGTTA; match class: 1	59	2.795796e-02	2
TF	TF:M11018	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN	140	2.805447e-02	2
TF	TF:M11531	Factor: E2F-2; motif: GCGCGCGCGYW	Factor: E2F-2; motif: GCGCGCGCGYW	121	2.900445e-02	2
TF	TF:M11434_1	Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1	Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1	42	2.973485e-02	2
TF	TF:M00430	Factor: E2F-1; motif: NTTSGCGG	Factor: E2F-1; motif: NTTSGCGG	85	2.991371e-02	2
TF	TF:M00428	Factor: E2F-1; motif: NKTSSCGC	Factor: E2F-1; motif: NKTSSCGC	92	3.007608e-02	2
TF	TF:M02059	Factor: ELK-1; motif: ACCGGAAGTN	Factor: ELK-1; motif: ACCGGAAGTN	95	3.066513e-02	2
TF	TF:M01752_1	Factor: ERG; motif: ACCGGAART; match class: 1	Factor: ERG; motif: ACCGGAART; match class: 1	49	3.146985e-02	2
TF	TF:M11428_1	Factor: PEA3; motif: NACCGGAAGTN; match class: 1	Factor: PEA3; motif: NACCGGAAGTN; match class: 1	34	3.213487e-02	2
TF	TF:M11404_1	Factor: Fli-1; motif: NACCGGAARTN; match class: 1	Factor: Fli-1; motif: NACCGGAARTN; match class: 1	44	3.230201e-02	2
TF	TF:M04519	Factor: E2F-4; motif: TTTGGCGCCAAA	Factor: E2F-4; motif: TTTGGCGCCAAA	59	3.233204e-02	2
TF	TF:M11529	Factor: E2F-2; motif: GCGCGCGCNCS	Factor: E2F-2; motif: GCGCGCGCNCS	137	3.502682e-02	2
TF	TF:M08525_1	Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1	Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1	132	3.536666e-02	2
TF	TF:M00737	Factor: E2F-1:DP-2; motif: TTTSSCGC	Factor: E2F-1:DP-2; motif: TTTSSCGC	90	3.548276e-02	2
TF	TF:M01820	Factor: CREM; motif: TGACGTCASYN	Factor: CREM; motif: TGACGTCASYN	71	3.617102e-02	2
TF	TF:M02064	Factor: c-ets-2; motif: ACCGGAWRTN	Factor: c-ets-2; motif: ACCGGAWRTN	105	4.050649e-02	2
TF	TF:M12600_1	Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN; match class: 1	Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN; match class: 1	44	4.095588e-02	2
TF	TF:M04287	Factor: BARHL2; motif: NNTAAAYGNN	Factor: BARHL2; motif: NNTAAAYGNN	55	4.238586e-02	2
TF	TF:M11221	Factor: CREB1; motif: RTGACGYGTCAN	Factor: CREB1; motif: RTGACGYGTCAN	96	4.241876e-02	2
TF	TF:M00427_1	Factor: E2F; motif: TTTSGCGS; match class: 1	Factor: E2F; motif: TTTSGCGS; match class: 1	50	4.340926e-02	2
TF	TF:M01145	Factor: c-Myc; motif: RACCACGTGCTC	Factor: c-Myc; motif: RACCACGTGCTC	70	4.742551e-02	2
TF	TF:M07612	Factor: PSF; motif: KWATCCGN	Factor: PSF; motif: KWATCCGN	65	4.944993e-02	2

Community 3

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	63	9.064835e-10	3
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	49	1.697803e-07	3
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	33	9.221231e-07	3
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	33	1.313976e-06	3
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	33	1.329424e-06	3
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	33	1.329424e-06	3
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	93	1.795316e-06	3
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	107	5.422251e-05	3
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	33	9.496019e-05	3
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	33	1.002722e-04	3
GO:CC	GO:0005662	DNA replication factor A complex	"A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]	4	1.438981e-04	3
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	38	1.830272e-04	3
GO:CC	GO:0043601	nuclear replisome	"A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu]	4	1.420914e-03	3
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	57	1.711555e-03	3
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	57	1.711555e-03	3
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	57	1.711555e-03	3
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	108	1.771412e-03	3
GO:CC	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	46	1.857295e-03	3
GO:CC	GO:0030894	replisome	"A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]	4	2.047879e-03	3
GO:CC	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	100	2.988437e-03	3
GO:CC	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	14	8.739041e-03	3
GO:CC	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	7	9.118080e-03	3
GO:CC	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	3	1.156746e-02	3
GO:CC	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	40	1.221611e-02	3
GO:CC	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	40	1.242119e-02	3
GO:CC	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	5	1.333136e-02	3
GO:CC	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	15	1.604770e-02	3
GO:CC	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	4	1.825542e-02	3
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	27	1.880832e-02	3
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	15	2.009778e-02	3
GO:CC	GO:0099073	mitochondrion-derived vesicle	"A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:18207745, PMID:20619655, PMID:22226745, PMID:23300790]	2	2.504522e-02	3
GO:CC	GO:0030663	COPI-coated vesicle membrane	"The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah]	3	3.239504e-02	3
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	99	4.000304e-02	3
GO:CC	GO:0005798	Golgi-associated vesicle	"Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]	5	4.336752e-02	3
GO:CC	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	25	4.613092e-02	3
GO:CC	GO:0099503	secretory vesicle	"A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]	16	4.680659e-02	3
GO:CC	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	5	4.779486e-02	3
GO:CC	GO:0070522	ERCC4-ERCC1 complex	"A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae." [PMID:14734547]	2	4.992313e-02	3

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0009056	catabolic process	"A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	38	0.000003	3
GO:BP	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	45	0.000080	3
GO:BP	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	12	0.000467	3
GO:BP	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	27	0.000876	3
GO:BP	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	11	0.001564	3
GO:BP	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	18	0.001749	3
GO:BP	GO:2001245	regulation of phosphatidylcholine biosynthetic process	"Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol]	3	0.002491	3
GO:BP	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	8	0.004164	3
GO:BP	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	27	0.004333	3
GO:BP	GO:0008219	cell death	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]	27	0.004502	3
GO:BP	GO:0019637	organophosphate metabolic process	"The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]	19	0.004747	3
GO:BP	GO:0150003	regulation of spontaneous synaptic transmission	"Any process that modulates the frequency, rate or extent of spontaneous synaptic transmission." [GOC:aruk, GOC:bc, PMID:15457210]	3	0.004963	3
GO:BP	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	5	0.007316	3
GO:BP	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	14	0.007454	3
GO:BP	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	6	0.008541	3
GO:BP	GO:0006753	nucleoside phosphate metabolic process	"The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah]	14	0.011704	3
GO:BP	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	13	0.012607	3
GO:BP	GO:0032200	telomere organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah]	8	0.012876	3
GO:BP	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	29	0.018036	3
GO:BP	GO:0006793	phosphorus metabolic process	"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]	29	0.018477	3
GO:BP	GO:0055086	nucleobase-containing small molecule metabolic process	"The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw]	14	0.018599	3
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	21	0.019946	3
GO:BP	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	69	0.022910	3
GO:BP	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	25	0.024359	3
GO:BP	GO:0150172	regulation of phosphatidylcholine metabolic process	"Any process that modulates the frequency, rate or extent of phosphatidylcholine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985]	3	0.029329	3
GO:BP	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	17	0.029515	3
GO:BP	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]	85	0.031101	3
GO:BP	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	13	0.035777	3
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	31	0.035834	3
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	31	0.039055	3
GO:BP	GO:0009650	UV protection	"Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml]	3	0.040176	3

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	13	0.000026	3
GO:MF	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	7	0.000120	3
GO:MF	GO:0005536	D-glucose binding	"Binding to D-enantiomers of glucose." [GOC:jl]	4	0.000237	3
GO:MF	GO:0036094	small molecule binding	"Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]	61	0.000995	3
GO:MF	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	14	0.001693	3
GO:MF	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	61	0.003681	3
GO:MF	GO:0043167	ion binding	"Binding to an ion, a charged atoms or groups of atoms." [GOC:jl]	58	0.004770	3
GO:MF	GO:0140431	DNA-(abasic site) binding	"Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base." [PMID:23245849]	2	0.016601	3
GO:MF	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	113	0.019336	3
GO:MF	GO:0042162	telomeric DNA binding	"Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]	4	0.031537	3
GO:MF	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	6	0.033976	3
GO:MF	GO:0004177	aminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain." [EC:3.4.11.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]	4	0.034990	3
GO:MF	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	5	0.038219	3
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	101	0.042202	3

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	PCNA-Dependent Long Patch Base Excision Repair	5	0.000276	3
REAC	REAC:R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	5	0.000702	3
REAC	REAC:R-HSA-69166	Removal of the Flap Intermediate	Removal of the Flap Intermediate	4	0.001788	3
REAC	REAC:R-HSA-69183	Processive synthesis on the lagging strand	Processive synthesis on the lagging strand	4	0.002423	3
REAC	REAC:R-HSA-174437	Removal of the Flap Intermediate from the C-strand	Removal of the Flap Intermediate from the C-strand	4	0.004171	3
REAC	REAC:R-HSA-73933	Resolution of Abasic Sites (AP sites)	Resolution of Abasic Sites (AP sites)	5	0.004635	3
REAC	REAC:R-HSA-174414	Processive synthesis on the C-strand of the telomere	Processive synthesis on the C-strand of the telomere	4	0.006707	3
REAC	REAC:R-HSA-6783310	Fanconi Anemia Pathway	Fanconi Anemia Pathway	5	0.006942	3
REAC	REAC:R-HSA-69186	Lagging Strand Synthesis	Lagging Strand Synthesis	4	0.008331	3
REAC	REAC:R-HSA-8863678	Neurodegenerative Diseases	Neurodegenerative Diseases	4	0.010227	3
REAC	REAC:R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	4	0.010227	3
REAC	REAC:R-HSA-9734009	Defective Intrinsic Pathway for Apoptosis	Defective Intrinsic Pathway for Apoptosis	4	0.017816	3
REAC	REAC:R-HSA-5693532	DNA Double-Strand Break Repair	DNA Double-Strand Break Repair	8	0.034199	3
REAC	REAC:R-HSA-3371511	HSF1 activation	HSF1 activation	3	0.049585	3

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0600431	Tonsil; germinal center cells[≥Low]	Tonsil; germinal center cells[≥Low]	68	0.000826	3
HPA	HPA:0310000	Lymph node	Lymph node	71	0.001736	3
HPA	HPA:0600221	Tonsil; squamous epithelial cells[≥Low]	Tonsil; squamous epithelial cells[≥Low]	71	0.004184	3
HPA	HPA:0600000	Tonsil	Tonsil	78	0.004733	3
HPA	HPA:0380000	Placenta	Placenta	76	0.007443	3
HPA	HPA:0300000	Lung	Lung	75	0.008603	3
HPA	HPA:0381202	Placenta; hofbauer cells[≥Medium]	Placenta; hofbauer cells[≥Medium]	12	0.010743	3
HPA	HPA:0310441	Lymph node; non-germinal center cells[≥Low]	Lymph node; non-germinal center cells[≥Low]	66	0.011363	3
HPA	HPA:0040000	Bone marrow	Bone marrow	69	0.011718	3
HPA	HPA:0040081	Bone marrow; hematopoietic cells[≥Low]	Bone marrow; hematopoietic cells[≥Low]	69	0.011718	3
HPA	HPA:0590051	Thyroid gland; glandular cells[≥Low]	Thyroid gland; glandular cells[≥Low]	73	0.013845	3
HPA	HPA:0590000	Thyroid gland	Thyroid gland	73	0.013845	3
HPA	HPA:0610832	Urinary bladder; urothelial cells[≥Medium]	Urinary bladder; urothelial cells[≥Medium]	65	0.014191	3
HPA	HPA:0430051	Seminal vesicle; glandular cells[≥Low]	Seminal vesicle; glandular cells[≥Low]	71	0.014554	3
HPA	HPA:0430000	Seminal vesicle	Seminal vesicle	71	0.014554	3
HPA	HPA:0381191	Placenta; cytotrophoblasts[≥Low]	Placenta; cytotrophoblasts[≥Low]	13	0.021808	3
HPA	HPA:0600432	Tonsil; germinal center cells[≥Medium]	Tonsil; germinal center cells[≥Medium]	50	0.024311	3
HPA	HPA:0630000	Cervix	Cervix	71	0.027934	3
HPA	HPA:0270000	Kidney	Kidney	79	0.032705	3
HPA	HPA:0020051	Adrenal gland; glandular cells[≥Low]	Adrenal gland; glandular cells[≥Low]	74	0.033447	3
HPA	HPA:0020000	Adrenal gland	Adrenal gland	74	0.035035	3
HPA	HPA:0190000	Esophagus	Esophagus	69	0.038692	3
HPA	HPA:0190221	Esophagus; squamous epithelial cells[≥Low]	Esophagus; squamous epithelial cells[≥Low]	69	0.038692	3
HPA	HPA:0381201	Placenta; hofbauer cells[≥Low]	Placenta; hofbauer cells[≥Low]	12	0.038923	3
HPA	HPA:0610000	Urinary bladder	Urinary bladder	73	0.044692	3
HPA	HPA:0610831	Urinary bladder; urothelial cells[≥Low]	Urinary bladder; urothelial cells[≥Low]	73	0.044692	3

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-let-7b-5p	hsa-let-7b-5p	hsa-let-7b-5p	22	0.002337	3
MIRNA	MIRNA:hsa-mir-30a-5p	hsa-mir-30a-5p	hsa-mir-30a-5p	15	0.027808	3
MIRNA	MIRNA:hsa-mir-629	hsa-mir-629	hsa-mir-629	16	0.044605	3

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:03460	Fanconi anemia pathway	Fanconi anemia pathway	5	0.003427	3
KEGG	KEGG:03420	Nucleotide excision repair	Nucleotide excision repair	5	0.006199	3
KEGG	KEGG:03030	DNA replication	DNA replication	4	0.010310	3
KEGG	KEGG:04210	Apoptosis	Apoptosis	6	0.034665	3
KEGG	KEGG:03430	Mismatch repair	Mismatch repair	3	0.047829	3

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:832	Anti-Sm protein complex	Anti-Sm protein complex	3	0.005237	3
CORUM	CORUM:5229	RPA complex	RPA complex	2	0.049954	3

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M10438_1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	104	0.008536	3
TF	TF:M12173	Factor: GKLF; motif: NNCCMCRCCCN	Factor: GKLF; motif: NNCCMCRCCCN	81	0.011911	3
TF	TF:M00736_1	Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1	Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1	48	0.018735	3
TF	TF:M00803	Factor: E2F; motif: GGCGSG	Factor: E2F; motif: GGCGSG	96	0.026324	3
TF	TF:M00716_1	Factor: ZF5; motif: GSGCGCGR; match class: 1	Factor: ZF5; motif: GSGCGCGR; match class: 1	100	0.028723	3
TF	TF:M07380	Factor: E2F-4; motif: NTTTCSCGCC	Factor: E2F-4; motif: NTTTCSCGCC	95	0.029932	3
TF	TF:M09894_1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	99	0.041627	3

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP3875	ATR signaling	ATR signaling	3	0.010475	3
WP	WP:WP5394	UDP derived sugars synthesis in fibroblasts	UDP derived sugars synthesis in fibroblasts	3	0.010475	3
WP	WP:WP5173	Disorders of galactose metabolism	Disorders of galactose metabolism	3	0.017962	3
WP	WP:WP5114	Nucleotide excision repair in xeroderma pigmentosum	Nucleotide excision repair in xeroderma pigmentosum	5	0.036492	3
WP	WP:WP5372	Involvement of secretase in neurodegenerative diseases	Involvement of secretase in neurodegenerative diseases	3	0.041794	3
WP	WP:WP4946	DNA repair pathways full network	DNA repair pathways full network	6	0.042094	3
WP	WP:WP4753	Nucleotide excision repair	Nucleotide excision repair	4	0.047225	3

Community 4

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0140110	transcription regulator activity	"A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]	61	1.505513e-37	4
GO:MF	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	30	1.738853e-23	4
GO:MF	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	32	2.141248e-23	4
GO:MF	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	42	1.072657e-22	4
GO:MF	GO:0000987	cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018]	40	1.688649e-22	4
GO:MF	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	45	1.913659e-22	4
GO:MF	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	43	2.899540e-22	4
GO:MF	GO:0001067	transcription regulatory region nucleic acid binding	"Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH]	43	2.978506e-22	4
GO:MF	GO:0001216	DNA-binding transcription activator activity	"A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018]	29	3.221308e-22	4
GO:MF	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	39	1.051351e-21	4
GO:MF	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	42	1.242578e-21	4
GO:MF	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	43	1.478118e-21	4
GO:MF	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	52	2.632457e-21	4
GO:MF	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	41	2.730249e-21	4
GO:MF	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	43	1.640564e-20	4
GO:MF	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]	27	8.226814e-20	4
GO:MF	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	34	3.915059e-16	4
GO:MF	GO:0030674	protein-macromolecule adaptor activity	"An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	30	3.289796e-14	4
GO:MF	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	20	3.563313e-14	4
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	40	9.976206e-14	4
GO:MF	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	20	2.523378e-11	4
GO:MF	GO:0001217	DNA-binding transcription repressor activity	"A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets." [GOC:txnOH-2018]	15	1.070667e-09	4
GO:MF	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	35	2.506363e-09	4
GO:MF	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	21	2.175086e-08	4
GO:MF	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	19	2.636482e-08	4
GO:MF	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	54	3.813064e-08	4
GO:MF	GO:0001221	transcription coregulator binding	"Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc]	10	7.457672e-08	4
GO:MF	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	13	1.349482e-07	4
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	89	7.857761e-07	4
GO:MF	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	18	1.465039e-06	4
GO:MF	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	9	3.224539e-06	4
GO:MF	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	10	1.155544e-04	4
GO:MF	GO:0044389	ubiquitin-like protein ligase binding	"Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]	11	1.266546e-04	4
GO:MF	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	9	1.637632e-04	4
GO:MF	GO:0043425	bHLH transcription factor binding	"Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210]	5	1.687419e-04	4
GO:MF	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	10	6.581192e-04	4
GO:MF	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	12	9.946008e-04	4
GO:MF	GO:0001223	transcription coactivator binding	"Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc]	5	1.218891e-03	4
GO:MF	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	18	1.258714e-03	4
GO:MF	GO:0019787	ubiquitin-like protein transferase activity	"Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686]	12	1.846726e-03	4
GO:MF	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	12	2.623136e-03	4
GO:MF	GO:0017151	DEAD/H-box RNA helicase binding	"Binding to a DEAD/H-box RNA helicase." [GOC:jl]	3	2.718941e-03	4
GO:MF	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-]	14	5.254054e-03	4
GO:MF	GO:0055106	ubiquitin-protein transferase regulator activity	"Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl]	4	7.945615e-03	4
GO:MF	GO:0046332	SMAD binding	"Binding to a SMAD signaling protein." [GOC:ai]	5	1.599356e-02	4
GO:MF	GO:0070411	I-SMAD binding	"Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]	3	2.648932e-02	4
GO:MF	GO:0097027	ubiquitin-protein transferase activator activity	"Binds to and increases the activity of a ubiquitin-protein transferase." [GOC:rb, PMID:18321851]	3	2.648932e-02	4
GO:MF	GO:0140693	molecular condensate scaffold activity	"Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate." [PMID:28225081]	4	2.776377e-02	4
GO:MF	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	6	3.336804e-02	4
GO:MF	GO:0032810	sterol response element binding	"Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism." [GOC:vk, PMID:11994399]	2	3.357789e-02	4
GO:MF	GO:0050816	phosphothreonine residue binding	"Binding to a phosphorylated threonine residue within a protein." [GOC:ai]	2	3.357789e-02	4
GO:MF	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	5	4.961179e-02	4

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	71	5.456450e-36	4
GO:BP	GO:2001141	regulation of RNA biosynthetic process	"Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]	71	7.967376e-36	4
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	51	4.172873e-35	4
GO:BP	GO:0051252	regulation of RNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	72	6.148538e-35	4
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	"Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	51	7.719994e-35	4
GO:BP	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	71	8.430487e-35	4
GO:BP	GO:0051253	negative regulation of RNA metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	52	1.795561e-34	4
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	63	1.014317e-33	4
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	"Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	72	1.399713e-32	4
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	"Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	52	1.491602e-32	4
GO:BP	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	63	2.068257e-32	4
GO:BP	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	79	5.140622e-32	4
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	65	1.062718e-29	4
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	41	3.727776e-28	4
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	45	6.935189e-28	4
GO:BP	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	76	1.961010e-27	4
GO:BP	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	65	2.503999e-27	4
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	"Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	76	7.811633e-27	4
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	49	8.970496e-27	4
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	49	9.471991e-27	4
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	"Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	52	2.045767e-26	4
GO:BP	GO:0051254	positive regulation of RNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	50	2.493622e-26	4
GO:BP	GO:0009889	regulation of biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	76	6.105955e-26	4
GO:BP	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	79	6.208696e-26	4
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	"Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	57	2.696138e-25	4
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	60	3.325313e-25	4
GO:BP	GO:0009890	negative regulation of biosynthetic process	"Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	57	9.780993e-25	4
GO:BP	GO:0009891	positive regulation of biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	56	1.215740e-24	4
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	"Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	55	1.882711e-24	4
GO:BP	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	60	1.321343e-23	4
GO:BP	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	79	2.435299e-23	4
GO:BP	GO:0045595	regulation of cell differentiation	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]	42	1.830242e-20	4
GO:BP	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	69	1.582350e-19	4
GO:BP	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	70	4.080404e-19	4
GO:BP	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	69	1.438695e-18	4
GO:BP	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	48	1.514929e-18	4
GO:BP	GO:0141187	nucleic acid biosynthetic process	"The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb]	73	3.459442e-18	4
GO:BP	GO:0016070	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	73	8.270092e-18	4
GO:BP	GO:0032774	RNA biosynthetic process	"The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]	72	1.042082e-17	4
GO:BP	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	70	1.386079e-17	4
GO:BP	GO:0090304	nucleic acid metabolic process	"Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb]	75	1.886658e-17	4
GO:BP	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	60	3.265488e-17	4
GO:BP	GO:0048869	cellular developmental process	"A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]	60	3.304395e-17	4
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	73	5.505422e-17	4
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	75	2.385480e-15	4
GO:BP	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	67	7.929073e-14	4
GO:BP	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	25	9.611242e-14	4
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	"Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph]	12	1.345167e-13	4
GO:BP	GO:0051093	negative regulation of developmental process	"Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	28	1.802770e-13	4
GO:BP	GO:2000628	regulation of miRNA metabolic process	"Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph]	13	1.879249e-13	4
GO:BP	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	77	5.748171e-13	4
GO:BP	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	63	8.755660e-13	4
GO:BP	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	46	9.511057e-13	4
GO:BP	GO:1902893	regulation of miRNA transcription	"Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]	12	9.976083e-13	4
GO:BP	GO:0061614	miRNA transcription	"The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799]	12	1.177727e-12	4
GO:BP	GO:0009059	macromolecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	78	1.559151e-12	4
GO:BP	GO:1902895	positive regulation of miRNA transcription	"Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]	11	1.677589e-12	4
GO:BP	GO:0010586	miRNA metabolic process	"The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]	13	1.722939e-12	4
GO:BP	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	36	1.784415e-12	4
GO:BP	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]	86	2.051933e-12	4
GO:BP	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	51	2.913912e-12	4
GO:BP	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	34	6.815145e-12	4
GO:BP	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	34	7.442518e-12	4
GO:BP	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	36	8.387932e-12	4
GO:BP	GO:0048732	gland development	"The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]	20	9.232993e-12	4
GO:BP	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	29	2.076175e-11	4
GO:BP	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	36	2.312370e-11	4
GO:BP	GO:0008219	cell death	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]	36	2.460454e-11	4
GO:BP	GO:0009058	biosynthetic process	"A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	80	2.907414e-11	4
GO:BP	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	43	4.063782e-11	4
GO:BP	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	84	4.139045e-11	4
GO:BP	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	25	4.241700e-11	4
GO:BP	GO:0043069	negative regulation of programmed cell death	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	25	9.323439e-11	4
GO:BP	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	35	2.249508e-10	4
GO:BP	GO:0051094	positive regulation of developmental process	"Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	29	2.853365e-10	4
GO:BP	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	30	3.563254e-10	4
GO:BP	GO:0009719	response to endogenous stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]	30	5.728414e-10	4
GO:BP	GO:0043067	regulation of programmed cell death	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	30	7.683923e-10	4
GO:BP	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	29	1.121097e-09	4
GO:BP	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	41	1.346714e-09	4
GO:BP	GO:0071495	cellular response to endogenous stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]	27	1.507495e-09	4
GO:BP	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	82	1.631543e-09	4
GO:BP	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	18	1.782084e-09	4
GO:BP	GO:0048583	regulation of response to stimulus	"Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	47	3.427434e-09	4
GO:BP	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	23	3.659508e-09	4
GO:BP	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	64	7.622172e-09	4
GO:BP	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	33	9.842741e-09	4
GO:BP	GO:0023057	negative regulation of signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	28	9.894611e-09	4
GO:BP	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	27	9.989690e-09	4
GO:BP	GO:0010648	negative regulation of cell communication	"Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	28	1.006081e-08	4
GO:BP	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	38	1.050484e-08	4
GO:BP	GO:0141124	intracellular signaling cassette	"An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg]	32	1.068661e-08	4
GO:BP	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	43	1.219521e-08	4
GO:BP	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	43	1.319314e-08	4
GO:BP	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	57	1.555461e-08	4
GO:BP	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	82	1.631814e-08	4
GO:BP	GO:0034097	response to cytokine	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl]	23	1.671612e-08	4
GO:BP	GO:1901652	response to peptide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]	23	2.297434e-08	4
GO:BP	GO:0030111	regulation of Wnt signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]	15	2.363176e-08	4
GO:BP	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	59	3.336797e-08	4
GO:BP	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	38	3.401088e-08	4
GO:BP	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	59	3.975301e-08	4
GO:BP	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	29	6.218495e-08	4
GO:BP	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	39	6.853695e-08	4
GO:BP	GO:0048863	stem cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]	13	8.955163e-08	4
GO:BP	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	25	9.130959e-08	4
GO:BP	GO:0008152	metabolic process	"A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	86	1.019563e-07	4
GO:BP	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	24	1.148500e-07	4
GO:BP	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	69	1.351297e-07	4
GO:BP	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	82	1.626230e-07	4
GO:BP	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	23	2.641075e-07	4
GO:BP	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	19	2.718223e-07	4
GO:BP	GO:0035295	tube development	"The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]	23	3.399993e-07	4
GO:BP	GO:0051148	negative regulation of muscle cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]	8	5.218808e-07	4
GO:BP	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	26	8.958149e-07	4
GO:BP	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	21	9.810761e-07	4
GO:BP	GO:0080134	regulation of response to stress	"Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	25	1.005536e-06	4
GO:BP	GO:0045444	fat cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators]	12	1.105388e-06	4
GO:BP	GO:0048511	rhythmic process	"Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid]	13	1.341091e-06	4
GO:BP	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	17	1.575262e-06	4
GO:BP	GO:0061061	muscle structure development	"The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]	18	1.585896e-06	4
GO:BP	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	47	1.590373e-06	4
GO:BP	GO:0001889	liver development	"The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X]	10	1.652614e-06	4
GO:BP	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	27	1.778671e-06	4
GO:BP	GO:0070887	cellular response to chemical stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]	31	1.836366e-06	4
GO:BP	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	32	1.847941e-06	4
GO:BP	GO:0061008	hepaticobiliary system development	"The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph]	10	2.014484e-06	4
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	"Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb]	12	2.106459e-06	4
GO:BP	GO:0044092	negative regulation of molecular function	"Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]	16	3.419379e-06	4
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	28	3.845203e-06	4
GO:BP	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	21	3.893281e-06	4
GO:BP	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	21	4.546474e-06	4
GO:BP	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	19	6.466839e-06	4
GO:BP	GO:0006954	inflammatory response	"The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732]	19	7.532335e-06	4
GO:BP	GO:0071354	cellular response to interleukin-6	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah]	6	9.780481e-06	4
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	22	1.033765e-05	4
GO:BP	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	13	1.340103e-05	4
GO:BP	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	19	1.723082e-05	4
GO:BP	GO:0031347	regulation of defense response	"Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah]	18	1.803021e-05	4
GO:BP	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	12	1.972564e-05	4
GO:BP	GO:0070848	response to growth factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah]	17	2.129299e-05	4
GO:BP	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	34	2.181511e-05	4
GO:BP	GO:0070741	response to interleukin-6	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah]	6	2.466484e-05	4
GO:BP	GO:0033993	response to lipid	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]	19	2.581109e-05	4
GO:BP	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	40	3.486388e-05	4
GO:BP	GO:0030855	epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]	17	3.516621e-05	4
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	23	4.293942e-05	4
GO:BP	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	21	4.376203e-05	4
GO:BP	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	12	4.499760e-05	4
GO:BP	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	10	4.721484e-05	4
GO:BP	GO:0032101	regulation of response to external stimulus	"Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	20	5.305739e-05	4
GO:BP	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	19	5.591529e-05	4
GO:BP	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	20	5.727491e-05	4
GO:BP	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	18	6.450480e-05	4
GO:BP	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	57	7.207456e-05	4
GO:BP	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	16	7.600043e-05	4
GO:BP	GO:0007507	heart development	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]	15	9.158913e-05	4
GO:BP	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	40	9.944211e-05	4
GO:BP	GO:0043434	response to peptide hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]	13	1.070703e-04	4
GO:BP	GO:0050673	epithelial cell proliferation	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544]	13	1.099430e-04	4
GO:BP	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	20	1.168219e-04	4
GO:BP	GO:0034612	response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	10	1.172128e-04	4
GO:BP	GO:0140467	integrated stress response signaling	"The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041]	6	1.253778e-04	4
GO:BP	GO:1902806	regulation of cell cycle G1/S phase transition	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]	9	1.474375e-04	4
GO:BP	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	19	1.573294e-04	4
GO:BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	"Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	10	1.750540e-04	4
GO:BP	GO:0002521	leukocyte differentiation	"The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264]	15	1.758527e-04	4
GO:BP	GO:0010647	positive regulation of cell communication	"Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	25	1.820135e-04	4
GO:BP	GO:0023056	positive regulation of signaling	"Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	25	1.839918e-04	4
GO:BP	GO:1901873	regulation of post-translational protein modification	"Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]	10	2.124530e-04	4
GO:BP	GO:0060284	regulation of cell development	"Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]	17	2.213929e-04	4
GO:BP	GO:0060767	epithelial cell proliferation involved in prostate gland development	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph]	4	2.300542e-04	4
GO:BP	GO:0045598	regulation of fat cell differentiation	"Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]	8	2.363244e-04	4
GO:BP	GO:0050727	regulation of inflammatory response	"Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]	12	2.372183e-04	4
GO:BP	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	17	2.448892e-04	4
GO:BP	GO:0062012	regulation of small molecule metabolic process	"Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]	11	2.774178e-04	4
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194]	18	2.845857e-04	4
GO:BP	GO:0051090	regulation of DNA-binding transcription factor activity	"Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	11	2.953647e-04	4
GO:BP	GO:0030879	mammary gland development	"The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833]	8	3.325545e-04	4
GO:BP	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419]	16	3.360876e-04	4
GO:BP	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	25	3.363467e-04	4
GO:BP	GO:0043009	chordate embryonic development	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu]	15	3.515573e-04	4
GO:BP	GO:0051147	regulation of muscle cell differentiation	"Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]	8	3.921420e-04	4
GO:BP	GO:0030324	lung development	"The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048]	9	4.035785e-04	4
GO:BP	GO:0030177	positive regulation of Wnt signaling pathway	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]	8	4.367702e-04	4
GO:BP	GO:0001701	in utero embryonic development	"The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu]	12	4.399214e-04	4
GO:BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	12	4.514877e-04	4
GO:BP	GO:0030323	respiratory tube development	"The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid]	9	4.782668e-04	4
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	"Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]	10	5.079553e-04	4
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	15	5.219872e-04	4
GO:BP	GO:0044419	biological process involved in interspecies interaction between organisms	"Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]	24	5.225260e-04	4
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:22651914, PMID:28096268]	11	5.724885e-04	4
GO:BP	GO:0001890	placenta development	"The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]	8	6.616641e-04	4
GO:BP	GO:0007623	circadian rhythm	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]	9	6.643976e-04	4
GO:BP	GO:0060537	muscle tissue development	"The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]	12	6.773737e-04	4
GO:BP	GO:0001503	ossification	"The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649]	12	6.773737e-04	4
GO:BP	GO:0051145	smooth muscle cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai]	6	7.961667e-04	4
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	18	7.966644e-04	4
GO:BP	GO:0040007	growth	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]	17	8.187403e-04	4
GO:BP	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	7	9.271404e-04	4
GO:BP	GO:0010832	negative regulation of myotube differentiation	"Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]	4	9.392019e-04	4
GO:BP	GO:0001756	somitogenesis	"The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544]	6	9.553599e-04	4
GO:BP	GO:0007178	cell surface receptor protein serine/threonine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	11	1.003393e-03	4
GO:BP	GO:0050678	regulation of epithelial cell proliferation	"Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai]	11	1.003393e-03	4
GO:BP	GO:0007517	muscle organ development	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]	11	1.030985e-03	4
GO:BP	GO:0051154	negative regulation of striated muscle cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]	5	1.141879e-03	4
GO:BP	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	9	1.143706e-03	4
GO:BP	GO:0060541	respiratory system development	"The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph]	9	1.187223e-03	4
GO:BP	GO:0032870	cellular response to hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah]	14	1.192850e-03	4
GO:BP	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	13	1.196078e-03	4
GO:BP	GO:0071772	response to BMP	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf]	8	1.237844e-03	4
GO:BP	GO:0071773	cellular response to BMP stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf]	8	1.237844e-03	4
GO:BP	GO:0032088	negative regulation of NF-kappaB transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb]	6	1.242365e-03	4
GO:BP	GO:0003188	heart valve formation	"The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]	4	1.248175e-03	4
GO:BP	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	22	1.319828e-03	4
GO:BP	GO:0002682	regulation of immune system process	"Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]	22	1.362990e-03	4
GO:BP	GO:1901698	response to nitrogen compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	18	1.380789e-03	4
GO:BP	GO:0044843	cell cycle G1/S phase transition	"The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle]	9	1.427037e-03	4
GO:BP	GO:0003205	cardiac chamber development	"The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]	8	1.484754e-03	4
GO:BP	GO:0010665	regulation of cardiac muscle cell apoptotic process	"Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]	5	1.498129e-03	4
GO:BP	GO:0051707	response to other organism	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai]	22	1.532616e-03	4
GO:BP	GO:0043207	response to external biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators]	22	1.582139e-03	4
GO:BP	GO:0070647	protein modification by small protein conjugation or removal	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah]	17	1.604210e-03	4
GO:BP	GO:0001649	osteoblast differentiation	"The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid]	9	1.648069e-03	4
GO:BP	GO:0001944	vasculature development	"The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409]	15	1.767911e-03	4
GO:BP	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	10	1.816548e-03	4
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	14	1.851510e-03	4
GO:BP	GO:0003170	heart valve development	"The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart]	6	1.875559e-03	4
GO:BP	GO:0048589	developmental growth	"The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]	14	1.884952e-03	4
GO:BP	GO:0010660	regulation of muscle cell apoptotic process	"Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]	6	2.029362e-03	4
GO:BP	GO:0002573	myeloid leukocyte differentiation	"The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251]	9	2.035073e-03	4
GO:BP	GO:0061323	cell proliferation involved in heart morphogenesis	"The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart]	4	2.084883e-03	4
GO:BP	GO:0070102	interleukin-6-mediated signaling pathway	"The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling]	4	2.084883e-03	4
GO:BP	GO:2000136	regulation of cell proliferation involved in heart morphogenesis	"Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]	4	2.084883e-03	4
GO:BP	GO:0038061	non-canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217]	7	2.122076e-03	4
GO:BP	GO:0010659	cardiac muscle cell apoptotic process	"A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb]	5	2.191196e-03	4
GO:BP	GO:0010662	regulation of striated muscle cell apoptotic process	"Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]	5	2.191196e-03	4
GO:BP	GO:0062197	cellular response to chemical stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712]	10	2.358159e-03	4
GO:BP	GO:0009607	response to biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]	22	2.375077e-03	4
GO:BP	GO:0051248	negative regulation of protein metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]	14	2.413646e-03	4
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	"Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb]	10	2.567657e-03	4
GO:BP	GO:0019216	regulation of lipid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]	10	2.567657e-03	4
GO:BP	GO:0046890	regulation of lipid biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]	8	2.599086e-03	4
GO:BP	GO:0031669	cellular response to nutrient levels	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]	9	2.671828e-03	4
GO:BP	GO:0003231	cardiac ventricle development	"The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]	7	2.782374e-03	4
GO:BP	GO:0042692	muscle cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators]	11	2.859381e-03	4
GO:BP	GO:0014706	striated muscle tissue development	"The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle]	11	3.072150e-03	4
GO:BP	GO:0010658	striated muscle cell apoptotic process	"A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb]	5	3.115434e-03	4
GO:BP	GO:0009628	response to abiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]	18	3.160677e-03	4
GO:BP	GO:0010657	muscle cell apoptotic process	"A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb]	6	3.184348e-03	4
GO:BP	GO:0007049	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]	22	3.185875e-03	4
GO:BP	GO:0022612	gland morphogenesis	"The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete]	7	3.255421e-03	4
GO:BP	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	17	3.275679e-03	4
GO:BP	GO:1901201	regulation of extracellular matrix assembly	"Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]	4	3.279524e-03	4
GO:BP	GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis	"Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]	3	3.415349e-03	4
GO:BP	GO:0045667	regulation of osteoblast differentiation	"Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]	7	3.427334e-03	4
GO:BP	GO:1903322	positive regulation of protein modification by small protein conjugation or removal	"Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	7	3.427334e-03	4
GO:BP	GO:1901875	positive regulation of post-translational protein modification	"Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]	7	3.606783e-03	4
GO:BP	GO:0061053	somite development	"The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph]	6	3.936634e-03	4
GO:BP	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	27	3.976177e-03	4
GO:BP	GO:0048565	digestive tract development	"The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]	7	4.193004e-03	4
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575]	9	4.204824e-03	4
GO:BP	GO:0032496	response to lipopolysaccharide	"Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464]	10	4.313334e-03	4
GO:BP	GO:0031399	regulation of protein modification process	"Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	17	4.370470e-03	4
GO:BP	GO:0071396	cellular response to lipid	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah]	13	4.618784e-03	4
GO:BP	GO:0048729	tissue morphogenesis	"The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid]	13	4.702402e-03	4
GO:BP	GO:0031396	regulation of protein ubiquitination	"Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	8	4.705322e-03	4
GO:BP	GO:0071559	response to transforming growth factor beta	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:mah]	9	5.221761e-03	4
GO:BP	GO:0035270	endocrine system development	"Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system]	7	5.606481e-03	4
GO:BP	GO:0030850	prostate gland development	"The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751]	5	5.870207e-03	4
GO:BP	GO:0072091	regulation of stem cell proliferation	"Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]	6	5.877829e-03	4
GO:BP	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	13	6.023158e-03	4
GO:BP	GO:1903131	mononuclear cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906]	12	6.551539e-03	4
GO:BP	GO:0002237	response to molecule of bacterial origin	"Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm]	10	6.843127e-03	4
GO:BP	GO:0033002	muscle cell proliferation	"The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah]	8	7.049041e-03	4
GO:BP	GO:0055123	digestive system development	"The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid]	7	7.069866e-03	4
GO:BP	GO:0019941	modification-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]	13	7.158965e-03	4
GO:BP	GO:0000165	MAPK cascade	"An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]	14	7.269851e-03	4
GO:BP	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	8	7.304201e-03	4
GO:BP	GO:0032103	positive regulation of response to external stimulus	"Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah]	13	7.664105e-03	4
GO:BP	GO:0043632	modification-dependent macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl]	13	7.795234e-03	4
GO:BP	GO:2000045	regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	7	8.458569e-03	4
GO:BP	GO:0003190	atrioventricular valve formation	"The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]	3	9.503742e-03	4
GO:BP	GO:0030509	BMP signaling pathway	"The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827]	7	1.006769e-02	4
GO:BP	GO:0045833	negative regulation of lipid metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]	6	1.019291e-02	4
GO:BP	GO:0042594	response to starvation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]	8	1.031813e-02	4
GO:BP	GO:0048568	embryonic organ development	"Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	11	1.036587e-02	4
GO:BP	GO:0030856	regulation of epithelial cell differentiation	"Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]	7	1.096324e-02	4
GO:BP	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	29	1.122818e-02	4
GO:BP	GO:0045165	cell fate commitment	"The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]	9	1.169874e-02	4
GO:BP	GO:2001233	regulation of apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	10	1.188539e-02	4
GO:BP	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	17	1.213896e-02	4
GO:BP	GO:0072132	mesenchyme morphogenesis	"The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10]	5	1.217840e-02	4
GO:BP	GO:1902531	regulation of intracellular signal transduction	"Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	23	1.251594e-02	4
GO:BP	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	14	1.269799e-02	4
GO:BP	GO:0098542	defense response to other organism	"Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]	18	1.270156e-02	4
GO:BP	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	9	1.338835e-02	4
GO:BP	GO:0033598	mammary gland epithelial cell proliferation	"The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:mah]	4	1.350123e-02	4
GO:BP	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	14	1.365738e-02	4
GO:BP	GO:0001816	cytokine production	"The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]	14	1.385683e-02	4
GO:BP	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	6	1.508767e-02	4
GO:BP	GO:0062014	negative regulation of small molecule metabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]	6	1.508767e-02	4
GO:BP	GO:0003179	heart valve morphogenesis	"The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart]	5	1.558310e-02	4
GO:BP	GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number." [GOC:sj, PMID:18280719, PMID:32838963, PMID:36973360]	4	1.561029e-02	4
GO:BP	GO:0035886	vascular associated smooth muscle cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954]	4	1.561029e-02	4
GO:BP	GO:0035282	segmentation	"The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689]	6	1.592065e-02	4
GO:BP	GO:0003279	cardiac septum development	"The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]	6	1.592065e-02	4
GO:BP	GO:0048738	cardiac muscle tissue development	"The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]	8	1.678051e-02	4
GO:BP	GO:0097193	intrinsic apoptotic signaling pathway	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]	9	1.740350e-02	4
GO:BP	GO:0036293	response to decreased oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al]	9	1.927662e-02	4
GO:BP	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development	"Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph]	3	2.023906e-02	4
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	7	2.081435e-02	4
GO:BP	GO:0009056	catabolic process	"A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	27	2.145023e-02	4
GO:BP	GO:0002009	morphogenesis of an epithelium	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]	11	2.265693e-02	4
GO:BP	GO:0034248	regulation of amide metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]	5	2.286912e-02	4
GO:BP	GO:0001655	urogenital system development	"The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators]	5	2.460125e-02	4
GO:BP	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	8	2.488023e-02	4
GO:BP	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	7	2.509097e-02	4
GO:BP	GO:0031667	response to nutrient levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]	11	2.578154e-02	4
GO:BP	GO:0060411	cardiac septum morphogenesis	"The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart]	5	2.643418e-02	4
GO:BP	GO:1902105	regulation of leukocyte differentiation	"Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]	9	2.725557e-02	4
GO:BP	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	28	2.898844e-02	4
GO:BP	GO:0019221	cytokine-mediated signaling pathway	"The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629]	11	2.980631e-02	4
GO:BP	GO:0001568	blood vessel development	"The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981]	13	3.135839e-02	4
GO:BP	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	10	3.151823e-02	4
GO:BP	GO:0061180	mammary gland epithelium development	"The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:yaf]	5	3.257930e-02	4
GO:BP	GO:0072089	stem cell proliferation	"The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]	6	3.358744e-02	4
GO:BP	GO:0030278	regulation of ossification	"Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators]	6	3.358744e-02	4
GO:BP	GO:0003281	ventricular septum development	"The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart]	5	3.485744e-02	4
GO:BP	GO:0048663	neuron fate commitment	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph]	5	3.485744e-02	4
GO:BP	GO:0042303	molting cycle	"The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732]	6	3.517485e-02	4
GO:BP	GO:0003206	cardiac chamber morphogenesis	"The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]	6	3.517485e-02	4
GO:BP	GO:0042633	hair cycle	"The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, PMID:12230507]	6	3.517485e-02	4
GO:BP	GO:0003157	endocardium development	"The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]	3	3.687526e-02	4
GO:BP	GO:0060379	cardiac muscle cell myoblast differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb]	3	3.687526e-02	4
GO:BP	GO:0051150	regulation of smooth muscle cell differentiation	"Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]	4	3.783932e-02	4
GO:BP	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	9	3.790209e-02	4
GO:BP	GO:0010565	regulation of ketone metabolic process	"Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb]	6	4.030421e-02	4
GO:BP	GO:0002268	follicular dendritic cell differentiation	"The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149]	2	4.118008e-02	4
GO:BP	GO:0061344	regulation of cell adhesion involved in heart morphogenesis	"Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]	2	4.118008e-02	4
GO:BP	GO:0003007	heart morphogenesis	"The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]	8	4.249001e-02	4
GO:BP	GO:0010721	negative regulation of cell development	"Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]	8	4.365074e-02	4
GO:BP	GO:0043433	negative regulation of DNA-binding transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl]	6	4.602086e-02	4
GO:BP	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	8	4.729410e-02	4
GO:BP	GO:0010944	negative regulation of transcription by competitive promoter binding	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site." [GOC:tb]	3	4.778928e-02	4
GO:BP	GO:0050810	regulation of steroid biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai]	5	4.817562e-02	4
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	38	4.962468e-02	4

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	47	9.227367e-30	4
GO:CC	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	68	6.741429e-28	4
GO:CC	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	32	1.046378e-26	4
GO:CC	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	50	3.473233e-26	4
GO:CC	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	69	9.663815e-22	4
GO:CC	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	85	4.017113e-20	4
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	71	1.753341e-18	4
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	71	1.753341e-18	4
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	71	1.753341e-18	4
GO:CC	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	18	4.984545e-15	4
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	65	1.489984e-13	4
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	65	1.502184e-13	4
GO:CC	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	87	3.943719e-09	4
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	52	1.904522e-08	4
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	89	5.511524e-08	4
GO:CC	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	88	9.839377e-08	4
GO:CC	GO:0017053	transcription repressor complex	"A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]	8	3.672754e-07	4
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	89	2.972456e-06	4
GO:CC	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	58	1.835680e-05	4
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	90	3.092378e-05	4
GO:CC	GO:0033256	I-kappaB/NF-kappaB complex	"A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm." [GOC:bf, GOC:mah, PMID:9407099]	3	8.059276e-05	4
GO:CC	GO:0071159	NF-kappaB complex	"A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946]	3	2.008815e-04	4
GO:CC	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	28	5.444813e-04	4
GO:CC	GO:0071144	heteromeric SMAD protein complex	"A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]	3	1.114914e-03	4
GO:CC	GO:0071141	SMAD protein complex	"A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020]	3	1.667391e-03	4
GO:CC	GO:0033257	Bcl3/NF-kappaB2 complex	"A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099]	2	5.028717e-03	4
GO:CC	GO:1990647	C/EBP complex	"A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121]	2	5.028717e-03	4
GO:CC	GO:0035525	NF-kappaB p50/p65 complex	"A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584]	2	5.028717e-03	4
GO:CC	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex	"A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [CORUM:2949, PMID:16510869]	2	1.504573e-02	4
GO:CC	GO:0036488	CHOP-C/EBP complex	"A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors." [GOC:bf, GOC:PARL, PMID:1547942]	2	1.504573e-02	4
GO:CC	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	12	1.620850e-02	4
GO:CC	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	8	1.679979e-02	4
GO:CC	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	13	1.980218e-02	4
GO:CC	GO:1990589	ATF4-CREB1 transcription factor complex	"Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway." [GOC:bhm, PMID:12871976]	2	3.001087e-02	4
GO:CC	GO:0031461	cullin-RING ubiquitin ligase complex	"Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]	6	4.038298e-02	4

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:05200	Pathways in cancer	Pathways in cancer	26	7.714921e-14	4
KEGG	KEGG:05166	Human T-cell leukemia virus 1 infection	Human T-cell leukemia virus 1 infection	17	1.443708e-11	4
KEGG	KEGG:05215	Prostate cancer	Prostate cancer	12	3.343580e-10	4
KEGG	KEGG:04668	TNF signaling pathway	TNF signaling pathway	12	2.118817e-09	4
KEGG	KEGG:05202	Transcriptional misregulation in cancer	Transcriptional misregulation in cancer	13	8.610991e-08	4
KEGG	KEGG:05222	Small cell lung cancer	Small cell lung cancer	10	8.868204e-08	4
KEGG	KEGG:05161	Hepatitis B	Hepatitis B	12	1.462483e-07	4
KEGG	KEGG:05203	Viral carcinogenesis	Viral carcinogenesis	13	1.514043e-07	4
KEGG	KEGG:05207	Chemical carcinogenesis - receptor activation	Chemical carcinogenesis - receptor activation	13	2.743769e-07	4
KEGG	KEGG:05220	Chronic myeloid leukemia	Chronic myeloid leukemia	9	2.987213e-07	4
KEGG	KEGG:05169	Epstein-Barr virus infection	Epstein-Barr virus infection	12	1.433203e-06	4
KEGG	KEGG:05212	Pancreatic cancer	Pancreatic cancer	8	6.045331e-06	4
KEGG	KEGG:05165	Human papillomavirus infection	Human papillomavirus infection	14	7.455626e-06	4
KEGG	KEGG:05226	Gastric cancer	Gastric cancer	10	9.082116e-06	4
KEGG	KEGG:04218	Cellular senescence	Cellular senescence	10	1.404874e-05	4
KEGG	KEGG:01522	Endocrine resistance	Endocrine resistance	8	3.490503e-05	4
KEGG	KEGG:04380	Osteoclast differentiation	Osteoclast differentiation	9	3.849542e-05	4
KEGG	KEGG:05221	Acute myeloid leukemia	Acute myeloid leukemia	7	4.418549e-05	4
KEGG	KEGG:05163	Human cytomegalovirus infection	Human cytomegalovirus infection	11	4.873655e-05	4
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	AGE-RAGE signaling pathway in diabetic complications	8	5.191030e-05	4
KEGG	KEGG:04625	C-type lectin receptor signaling pathway	C-type lectin receptor signaling pathway	8	7.020425e-05	4
KEGG	KEGG:04931	Insulin resistance	Insulin resistance	8	9.374659e-05	4
KEGG	KEGG:04934	Cushing syndrome	Cushing syndrome	9	1.338573e-04	4
KEGG	KEGG:05225	Hepatocellular carcinoma	Hepatocellular carcinoma	9	2.636376e-04	4
KEGG	KEGG:04211	Longevity regulating pathway	Longevity regulating pathway	7	3.081430e-04	4
KEGG	KEGG:04064	NF-kappa B signaling pathway	NF-kappa B signaling pathway	7	7.658820e-04	4
KEGG	KEGG:04659	Th17 cell differentiation	Th17 cell differentiation	7	9.276734e-04	4
KEGG	KEGG:05224	Breast cancer	Breast cancer	8	9.460797e-04	4
KEGG	KEGG:05219	Bladder cancer	Bladder cancer	5	9.545825e-04	4
KEGG	KEGG:04350	TGF-beta signaling pathway	TGF-beta signaling pathway	7	1.050537e-03	4
KEGG	KEGG:05223	Non-small cell lung cancer	Non-small cell lung cancer	6	1.142100e-03	4
KEGG	KEGG:04110	Cell cycle	Cell cycle	8	1.530439e-03	4
KEGG	KEGG:05030	Cocaine addiction	Cocaine addiction	5	2.320689e-03	4
KEGG	KEGG:04919	Thyroid hormone signaling pathway	Thyroid hormone signaling pathway	7	2.345357e-03	4
KEGG	KEGG:04310	Wnt signaling pathway	Wnt signaling pathway	8	3.213167e-03	4
KEGG	KEGG:04658	Th1 and Th2 cell differentiation	Th1 and Th2 cell differentiation	6	3.851041e-03	4
KEGG	KEGG:04151	PI3K-Akt signaling pathway	PI3K-Akt signaling pathway	11	4.283737e-03	4
KEGG	KEGG:05162	Measles	Measles	7	5.453187e-03	4
KEGG	KEGG:04120	Ubiquitin mediated proteolysis	Ubiquitin mediated proteolysis	7	5.974887e-03	4
KEGG	KEGG:05206	MicroRNAs in cancer	MicroRNAs in cancer	10	6.830830e-03	4
KEGG	KEGG:05167	Kaposi sarcoma-associated herpesvirus infection	Kaposi sarcoma-associated herpesvirus infection	8	6.948530e-03	4
KEGG	KEGG:04137	Mitophagy - animal	Mitophagy - animal	6	8.740793e-03	4
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	Parathyroid hormone synthesis, secretion and action	6	9.725350e-03	4
KEGG	KEGG:05216	Thyroid cancer	Thyroid cancer	4	1.235788e-02	4
KEGG	KEGG:05160	Hepatitis C	Hepatitis C	7	1.277439e-02	4
KEGG	KEGG:04917	Prolactin signaling pathway	Prolactin signaling pathway	5	1.306912e-02	4
KEGG	KEGG:05218	Melanoma	Melanoma	5	1.493744e-02	4
KEGG	KEGG:04024	cAMP signaling pathway	cAMP signaling pathway	8	1.824180e-02	4
KEGG	KEGG:04152	AMPK signaling pathway	AMPK signaling pathway	6	2.024582e-02	4
KEGG	KEGG:04926	Relaxin signaling pathway	Relaxin signaling pathway	6	2.993473e-02	4
KEGG	KEGG:04068	FoxO signaling pathway	FoxO signaling pathway	6	3.251295e-02	4
KEGG	KEGG:05210	Colorectal cancer	Colorectal cancer	5	3.433565e-02	4
KEGG	KEGG:04210	Apoptosis	Apoptosis	6	3.818950e-02	4
KEGG	KEGG:04915	Estrogen signaling pathway	Estrogen signaling pathway	6	3.972273e-02	4
KEGG	KEGG:04657	IL-17 signaling pathway	IL-17 signaling pathway	5	4.685940e-02	4

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5434	Cancer pathways	Cancer pathways	26	3.995703e-12	4
WP	WP:WP4674	Head and neck squamous cell carcinoma	Head and neck squamous cell carcinoma	11	3.962259e-09	4
WP	WP:WP5144	NRP1 triggered signaling in pancreatic cancer	NRP1 triggered signaling in pancreatic cancer	9	8.479682e-08	4
WP	WP:WP5272	LDL influence on CD14 and TLR4	LDL influence on CD14 and TLR4	7	9.529607e-08	4
WP	WP:WP4331	Neovascularization processes	Neovascularization processes	8	1.067578e-07	4
WP	WP:WP236	Adipogenesis	Adipogenesis	12	1.387554e-07	4
WP	WP:WP1984	Integrated breast cancer pathway	Integrated breast cancer pathway	12	8.443352e-07	4
WP	WP:WP4658	Small cell lung cancer	Small cell lung cancer	10	1.105959e-06	4
WP	WP:WP4149	White fat cell differentiation	White fat cell differentiation	7	1.230399e-06	4
WP	WP:WP2018	RANKL RANK signaling	RANKL RANK signaling	8	1.358290e-06	4
WP	WP:WP4482	Vitamin D in inflammatory diseases	Vitamin D in inflammatory diseases	6	3.678825e-06	4
WP	WP:WP3599	Transcription factor regulation in adipogenesis	Transcription factor regulation in adipogenesis	6	3.678825e-06	4
WP	WP:WP4879	Overlap between signal transduction pathways contributing to LMNA laminopathies	Overlap between signal transduction pathways contributing to LMNA laminopathies	8	3.985148e-06	4
WP	WP:WP138	Androgen receptor signaling	Androgen receptor signaling	9	6.331541e-06	4
WP	WP:WP5474	Catabolism of skeletal muscle in cachexia	Catabolism of skeletal muscle in cachexia	7	6.453063e-06	4
WP	WP:WP4211	Transcriptional cascade regulating adipogenesis	Transcriptional cascade regulating adipogenesis	5	8.377752e-06	4
WP	WP:WP45	G1 to S cell cycle control	G1 to S cell cycle control	8	1.017565e-05	4
WP	WP:WP3981	miRNA regulation of prostate cancer signaling	miRNA regulation of prostate cancer signaling	6	3.415392e-05	4
WP	WP:WP2112	IL17 signaling	IL17 signaling	6	4.175166e-05	4
WP	WP:WP4754	IL18 signaling	IL18 signaling	7	7.196991e-05	4
WP	WP:WP3617	Photodynamic therapy induced NF kB survival signaling	Photodynamic therapy induced NF kB survival signaling	6	7.327996e-05	4
WP	WP:WP4844	Influence of laminopathies on Wnt signaling	Influence of laminopathies on Wnt signaling	6	1.035430e-04	4
WP	WP:WP2036	TNF related weak inducer of apoptosis TWEAK signaling	TNF related weak inducer of apoptosis TWEAK signaling	6	1.221270e-04	4
WP	WP:WP4263	Pancreatic adenocarcinoma pathway	Pancreatic adenocarcinoma pathway	8	1.253986e-04	4
WP	WP:WP706	Sudden infant death syndrome SIDS susceptibility pathways	Sudden infant death syndrome SIDS susceptibility pathways	10	1.508318e-04	4
WP	WP:WP5293	Acute myeloid leukemia	Acute myeloid leukemia	7	2.771937e-04	4
WP	WP:WP2064	Neural crest differentiation	Neural crest differentiation	8	3.607195e-04	4
WP	WP:WP2586	Aryl hydrocarbon receptor pathway	Aryl hydrocarbon receptor pathway	6	3.925112e-04	4
WP	WP:WP615	Senescence and autophagy in cancer	Senescence and autophagy in cancer	8	4.842284e-04	4
WP	WP:WP5477	Molecular pathway for oxidative stress	Molecular pathway for oxidative stress	6	5.741987e-04	4
WP	WP:WP5353	Macrophage stimulating protein MSP signaling	Macrophage stimulating protein MSP signaling	8	5.989471e-04	4
WP	WP:WP710	DNA damage response only ATM dependent	DNA damage response only ATM dependent	8	6.419812e-04	4
WP	WP:WP5373	Osteoarthritic chondrocyte hypertrophy	Osteoarthritic chondrocyte hypertrophy	6	6.480950e-04	4
WP	WP:WP4874	CAMKK2 pathway	CAMKK2 pathway	8	6.876121e-04	4
WP	WP:WP61	Notch signaling	Notch signaling	6	8.191448e-04	4
WP	WP:WP2263	Androgen receptor network in prostate cancer	Androgen receptor network in prostate cancer	8	8.413739e-04	4
WP	WP:WP4659	Gastrin signaling	Gastrin signaling	8	8.987039e-04	4
WP	WP:WP4666	Hepatitis B infection	Hepatitis B infection	9	9.117729e-04	4
WP	WP:WP3858	Toll like receptor signaling related to MyD88	Toll like receptor signaling related to MyD88	5	9.807233e-04	4
WP	WP:WP4262	Breast cancer pathway	Breast cancer pathway	9	1.014900e-03	4
WP	WP:WP5113	Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway	Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway	5	1.154607e-03	4
WP	WP:WP2374	Oncostatin M signaling	Oncostatin M signaling	6	1.271497e-03	4
WP	WP:WP179	Cell cycle	Cell cycle	8	1.316959e-03	4
WP	WP:WP3995	Prion disease pathway	Prion disease pathway	5	1.351736e-03	4
WP	WP:WP2840	Hair follicle development cytodifferentiation stage 3 of 3	Hair follicle development cytodifferentiation stage 3 of 3	7	1.467711e-03	4
WP	WP:WP2446	Retinoblastoma gene in cancer	Retinoblastoma gene in cancer	7	1.707227e-03	4
WP	WP:WP2882	Nuclear receptors meta pathway	Nuclear receptors meta pathway	12	2.082441e-03	4
WP	WP:WP2203	Thymic stromal lymphopoietin TSLP signaling	Thymic stromal lymphopoietin TSLP signaling	5	2.104590e-03	4
WP	WP:WP5180	DYRK1A involvement regarding cell proliferation in brain development	DYRK1A involvement regarding cell proliferation in brain development	6	2.311603e-03	4
WP	WP:WP5269	Genetic causes of porto sinusoidal vascular disease	Genetic causes of porto sinusoidal vascular disease	5	2.417253e-03	4
WP	WP:WP4630	Measles virus infection	Measles virus infection	8	3.305988e-03	4
WP	WP:WP2828	Bladder cancer	Bladder cancer	5	3.576680e-03	4
WP	WP:WP5331	Autophagy in pancreatic ductal adenocarcinoma	Autophagy in pancreatic ductal adenocarcinoma	4	3.694282e-03	4
WP	WP:WP4685	Melanoma	Melanoma	6	3.952001e-03	4
WP	WP:WP1545	miRNAs involved in DNA damage response	miRNAs involved in DNA damage response	6	3.952001e-03	4
WP	WP:WP707	DNA damage response	DNA damage response	6	4.299202e-03	4
WP	WP:WP4255	Non small cell lung cancer	Non small cell lung cancer	6	5.490693e-03	4
WP	WP:WP5300	TROP2 regulatory signaling	TROP2 regulatory signaling	5	5.747786e-03	4
WP	WP:WP1530	miRNA regulation of DNA damage response	miRNA regulation of DNA damage response	6	5.942076e-03	4
WP	WP:WP4341	Non genomic actions of 1 25 dihydroxyvitamin D3	Non genomic actions of 1 25 dihydroxyvitamin D3	6	6.422795e-03	4
WP	WP:WP712	Estrogen signaling	Estrogen signaling	4	6.621615e-03	4
WP	WP:WP262	Ebstein Barr virus LMP1 signaling	Ebstein Barr virus LMP1 signaling	4	6.621615e-03	4
WP	WP:WP1591	Heart development	Heart development	5	7.957798e-03	4
WP	WP:WP28	Selenium metabolism and selenoproteins	Selenium metabolism and selenoproteins	5	7.957798e-03	4
WP	WP:WP3926	ApoE and miR 146 in inflammation and atherosclerosis	ApoE and miR 146 in inflammation and atherosclerosis	3	8.321946e-03	4
WP	WP:WP4480	Altered glycosylation of MUC1 in tumor microenvironment	Altered glycosylation of MUC1 in tumor microenvironment	3	8.321946e-03	4
WP	WP:WP2431	Spinal cord injury	Spinal cord injury	7	9.092627e-03	4
WP	WP:WP2895	Differentiation of white and brown adipocyte	Differentiation of white and brown adipocyte	4	9.337442e-03	4
WP	WP:WP5205	Clock controlled autophagy in bone metabolism	Clock controlled autophagy in bone metabolism	6	1.000440e-02	4
WP	WP:WP3611	Photodynamic therapy induced AP 1 survival signaling	Photodynamic therapy induced AP 1 survival signaling	5	1.077424e-02	4
WP	WP:WP395	IL4 signaling	IL4 signaling	5	1.077424e-02	4
WP	WP:WP2261	Glioblastoma signaling	Glioblastoma signaling	6	1.150122e-02	4
WP	WP:WP5036	Angiotensin II receptor type 1 pathway	Angiotensin II receptor type 1 pathway	4	1.482205e-02	4
WP	WP:WP254	Apoptosis	Apoptosis	6	1.603525e-02	4
WP	WP:WP5098	T cell activation SARS CoV 2	T cell activation SARS CoV 2	6	1.709268e-02	4
WP	WP:WP231	TNF alpha signaling	TNF alpha signaling	6	1.820488e-02	4
WP	WP:WP3646	Hepatitis C and hepatocellular carcinoma	Hepatitis C and hepatocellular carcinoma	5	1.866363e-02	4
WP	WP:WP4746	Thyroid hormones production and peripheral downstream signaling effects	Thyroid hormones production and peripheral downstream signaling effects	6	2.324297e-02	4
WP	WP:WP3414	Initiation of transcription and translation elongation at the HIV 1 LTR	Initiation of transcription and translation elongation at the HIV 1 LTR	4	2.536537e-02	4
WP	WP:WP1434	Osteopontin signaling	Osteopontin signaling	3	2.764284e-02	4
WP	WP:WP5475	Hallmark of cancer sustaining proliferative signaling	Hallmark of cancer sustaining proliferative signaling	6	3.103152e-02	4
WP	WP:WP4329	miRNA role in immune response in sepsis	miRNA role in immune response in sepsis	5	3.278005e-02	4
WP	WP:WP3651	Pathways affected in adenoid cystic carcinoma	Pathways affected in adenoid cystic carcinoma	5	3.801221e-02	4
WP	WP:WP2857	Mesodermal commitment pathway	Mesodermal commitment pathway	7	4.073755e-02	4
WP	WP:WP2324	AGE RAGE pathway	AGE RAGE pathway	5	4.085540e-02	4
WP	WP:WP5367	Rubinstein Taybi syndrome 1	Rubinstein Taybi syndrome 1	3	4.343790e-02	4
WP	WP:WP3	Transcriptional activation by NRF2 in response to phytochemicals	Transcriptional activation by NRF2 in response to phytochemicals	3	4.343790e-02	4
WP	WP:WP3594	Circadian rhythm genes	Circadian rhythm genes	8	4.995797e-02	4
WP	WP:WP5087	Pleural mesothelioma	Pleural mesothelioma	12	4.999962e-02	4

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-212436	Generic Transcription Pathway	Generic Transcription Pathway	32	5.653939e-10	4
REAC	REAC:R-HSA-9843745	Adipogenesis	Adipogenesis	12	1.943589e-09	4
REAC	REAC:R-HSA-74160	Gene expression (Transcription)	Gene expression (Transcription)	34	5.090465e-09	4
REAC	REAC:R-HSA-73857	RNA Polymerase II Transcription	RNA Polymerase II Transcription	32	7.156614e-09	4
REAC	REAC:R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	Transcriptional regulation of white adipocyte differentiation	10	5.869741e-08	4
REAC	REAC:R-HSA-2262752	Cellular responses to stress	Cellular responses to stress	22	1.830574e-06	4
REAC	REAC:R-HSA-8953897	Cellular responses to stimuli	Cellular responses to stimuli	22	2.526919e-06	4
REAC	REAC:R-HSA-8878166	Transcriptional regulation by RUNX2	Transcriptional regulation by RUNX2	9	3.060524e-05	4
REAC	REAC:R-HSA-1280215	Cytokine Signaling in Immune system	Cytokine Signaling in Immune system	20	3.880400e-05	4
REAC	REAC:R-HSA-9818749	Regulation of NFE2L2 gene expression	Regulation of NFE2L2 gene expression	4	4.971318e-05	4
REAC	REAC:R-HSA-8853884	Transcriptional Regulation by VENTX	Transcriptional Regulation by VENTX	6	7.714281e-05	4
REAC	REAC:R-HSA-1266738	Developmental Biology	Developmental Biology	26	1.444738e-04	4
REAC	REAC:R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	Toll Like Receptor 3 (TLR3) Cascade	8	1.480470e-04	4
REAC	REAC:R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	TRIF (TICAM1)-mediated TLR4 signaling	8	1.987215e-04	4
REAC	REAC:R-HSA-166166	MyD88-independent TLR4 cascade	MyD88-independent TLR4 cascade	8	1.987215e-04	4
REAC	REAC:R-HSA-2559583	Cellular Senescence	Cellular Senescence	10	2.215366e-04	4
REAC	REAC:R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	6	3.547250e-04	4
REAC	REAC:R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	Downregulation of SMAD2/3:SMAD4 transcriptional activity	5	4.768981e-04	4
REAC	REAC:R-HSA-8941326	RUNX2 regulates bone development	RUNX2 regulates bone development	5	5.693345e-04	4
REAC	REAC:R-HSA-9755511	KEAP1-NFE2L2 pathway	KEAP1-NFE2L2 pathway	8	6.136164e-04	4
REAC	REAC:R-HSA-9616222	Transcriptional regulation of granulopoiesis	Transcriptional regulation of granulopoiesis	7	6.565285e-04	4
REAC	REAC:R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	4	6.897790e-04	4
REAC	REAC:R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	SUMO E3 ligases SUMOylate target proteins	9	7.557295e-04	4
REAC	REAC:R-HSA-9725371	Nuclear events stimulated by ALK signaling in cancer	Nuclear events stimulated by ALK signaling in cancer	5	7.962764e-04	4
REAC	REAC:R-HSA-2990846	SUMOylation	SUMOylation	9	1.004186e-03	4
REAC	REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	Transcriptional regulation by RUNX3	7	1.190350e-03	4
REAC	REAC:R-HSA-9759194	Nuclear events mediated by NFE2L2	Nuclear events mediated by NFE2L2	7	1.190350e-03	4
REAC	REAC:R-HSA-5621481	C-type lectin receptors (CLRs)	C-type lectin receptors (CLRs)	8	1.231241e-03	4
REAC	REAC:R-HSA-5607764	CLEC7A (Dectin-1) signaling	CLEC7A (Dectin-1) signaling	7	1.369351e-03	4
REAC	REAC:R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	Aberrant regulation of mitotic cell cycle due to RB1 defects	5	1.460273e-03	4
REAC	REAC:R-HSA-5688426	Deubiquitination	Deubiquitination	11	1.550628e-03	4
REAC	REAC:R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	4	1.615504e-03	4
REAC	REAC:R-HSA-9659787	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	4	1.615504e-03	4
REAC	REAC:R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	Toll Like Receptor 4 (TLR4) Cascade	8	1.791520e-03	4
REAC	REAC:R-HSA-9675126	Diseases of mitotic cell cycle	Diseases of mitotic cell cycle	5	1.924328e-03	4
REAC	REAC:R-HSA-8849470	PTK6 Regulates Cell Cycle	PTK6 Regulates Cell Cycle	3	2.245144e-03	4
REAC	REAC:R-HSA-9711123	Cellular response to chemical stress	Cellular response to chemical stress	9	3.876826e-03	4
REAC	REAC:R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	3	3.910265e-03	4
REAC	REAC:R-HSA-8941855	RUNX3 regulates CDKN1A transcription	RUNX3 regulates CDKN1A transcription	3	3.910265e-03	4
REAC	REAC:R-HSA-5603029	IkBA variant leads to EDA-ID	IkBA variant leads to EDA-ID	3	3.910265e-03	4
REAC	REAC:R-HSA-168898	Toll-like Receptor Cascades	Toll-like Receptor Cascades	8	5.148926e-03	4
REAC	REAC:R-HSA-69236	G1 Phase	G1 Phase	5	5.614352e-03	4
REAC	REAC:R-HSA-69231	Cyclin D associated events in G1	Cyclin D associated events in G1	5	5.614352e-03	4
REAC	REAC:R-HSA-5689880	Ub-specific processing proteases	Ub-specific processing proteases	9	5.842852e-03	4
REAC	REAC:R-HSA-9006936	Signaling by TGFB family members	Signaling by TGFB family members	7	6.260213e-03	4
REAC	REAC:R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	DDX58/IFIH1-mediated induction of interferon-alpha/beta	6	6.613131e-03	4
REAC	REAC:R-HSA-448706	Interleukin-1 processing	Interleukin-1 processing	3	9.295378e-03	4
REAC	REAC:R-HSA-1643685	Disease	Disease	27	1.013562e-02	4
REAC	REAC:R-HSA-9725370	Signaling by ALK fusions and activated point mutants	Signaling by ALK fusions and activated point mutants	6	1.058092e-02	4
REAC	REAC:R-HSA-9700206	Signaling by ALK in cancer	Signaling by ALK in cancer	6	1.058092e-02	4
REAC	REAC:R-HSA-162582	Signal Transduction	Signal Transduction	33	1.146856e-02	4
REAC	REAC:R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	5	1.221887e-02	4
REAC	REAC:R-HSA-170834	Signaling by TGF-beta Receptor Complex	Signaling by TGF-beta Receptor Complex	6	1.278197e-02	4
REAC	REAC:R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	Diseases of signal transduction by growth factor receptors and second messengers	12	1.279308e-02	4
REAC	REAC:R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	Toll Like Receptor 5 (TLR5) Cascade	6	1.533701e-02	4
REAC	REAC:R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	Toll Like Receptor 10 (TLR10) Cascade	6	1.533701e-02	4
REAC	REAC:R-HSA-9692914	SARS-CoV-1-host interactions	SARS-CoV-1-host interactions	6	1.533701e-02	4
REAC	REAC:R-HSA-975871	MyD88 cascade initiated on plasma membrane	MyD88 cascade initiated on plasma membrane	6	1.533701e-02	4
REAC	REAC:R-HSA-9843743	Transcriptional regulation of brown and beige adipocyte differentiation	Transcriptional regulation of brown and beige adipocyte differentiation	4	1.742738e-02	4
REAC	REAC:R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	4	1.742738e-02	4
REAC	REAC:R-HSA-9844594	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	4	1.742738e-02	4
REAC	REAC:R-HSA-9818030	NFE2L2 regulating tumorigenic genes	NFE2L2 regulating tumorigenic genes	3	1.808520e-02	4
REAC	REAC:R-HSA-201451	Signaling by BMP	Signaling by BMP	4	1.990917e-02	4
REAC	REAC:R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	6	2.049423e-02	4
REAC	REAC:R-HSA-975155	MyD88 dependent cascade initiated on endosome	MyD88 dependent cascade initiated on endosome	6	2.167522e-02	4
REAC	REAC:R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	Toll Like Receptor 7/8 (TLR7/8) Cascade	6	2.291008e-02	4
REAC	REAC:R-HSA-2559585	Oncogene Induced Senescence	Oncogene Induced Senescence	4	2.563350e-02	4
REAC	REAC:R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	Toll Like Receptor 9 (TLR9) Cascade	6	2.695609e-02	4
REAC	REAC:R-HSA-9614085	FOXO-mediated transcription	FOXO-mediated transcription	5	2.966347e-02	4
REAC	REAC:R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	4	3.634940e-02	4
REAC	REAC:R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	Senescence-Associated Secretory Phenotype (SASP)	6	3.675703e-02	4
REAC	REAC:R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	6	3.675703e-02	4
REAC	REAC:R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	Toll Like Receptor TLR6:TLR2 Cascade	6	3.675703e-02	4
REAC	REAC:R-HSA-9730414	MITF-M-regulated melanocyte development	MITF-M-regulated melanocyte development	6	3.863562e-02	4
REAC	REAC:R-HSA-1989781	PPARA activates gene expression	PPARA activates gene expression	6	4.058989e-02	4
REAC	REAC:R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	Toll Like Receptor 2 (TLR2) Cascade	6	4.262207e-02	4
REAC	REAC:R-HSA-400206	Regulation of lipid metabolism by PPARalpha	Regulation of lipid metabolism by PPARalpha	6	4.262207e-02	4
REAC	REAC:R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	Toll Like Receptor TLR1:TLR2 Cascade	6	4.262207e-02	4
REAC	REAC:R-HSA-597592	Post-translational protein modification	Post-translational protein modification	22	4.734110e-02	4
REAC	REAC:R-HSA-9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	3	4.892832e-02	4
REAC	REAC:R-HSA-9648895	Response of EIF2AK1 (HRI) to heme deficiency	Response of EIF2AK1 (HRI) to heme deficiency	3	4.892832e-02	4
REAC	REAC:R-HSA-844456	The NLRP3 inflammasome	The NLRP3 inflammasome	3	4.892832e-02	4

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M12590_1	Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1	Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1	56	0.000335	4
TF	TF:M01219	Factor: SP1:SP3; motif: CCSCCCCCYCC	Factor: SP1:SP3; motif: CCSCCCCCYCC	56	0.000552	4
TF	TF:M04953_1	Factor: Sp1; motif: GGNDGGRGGCGGGG; match class: 1	Factor: Sp1; motif: GGNDGGRGGCGGGG; match class: 1	41	0.000599	4
TF	TF:M12722_1	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1	55	0.000675	4
TF	TF:M09834	Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN	Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN	56	0.001188	4
TF	TF:M04953	Factor: Sp1; motif: GGNDGGRGGCGGGG	Factor: Sp1; motif: GGNDGGRGGCGGGG	64	0.001492	4
TF	TF:M00695_1	Factor: ETF; motif: GVGGMGG; match class: 1	Factor: ETF; motif: GVGGMGG; match class: 1	56	0.001752	4
TF	TF:M10072_1	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1	52	0.002050	4
TF	TF:M12351_1	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1	61	0.002152	4
TF	TF:M00986_1	Factor: Churchill; motif: CGGGNN; match class: 1	Factor: Churchill; motif: CGGGNN; match class: 1	71	0.002407	4
TF	TF:M13127	Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS	Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS	78	0.002803	4
TF	TF:M11401_1	Factor: Fli-1; motif: NACCGGATATCCGGTN; match class: 1	Factor: Fli-1; motif: NACCGGATATCCGGTN; match class: 1	76	0.003082	4
TF	TF:M06948	Factor: Sp2; motif: TGGGCGCGCCCA	Factor: Sp2; motif: TGGGCGCGCCCA	64	0.003677	4
TF	TF:M10112	Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR	Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR	63	0.004643	4
TF	TF:M11401	Factor: Fli-1; motif: NACCGGATATCCGGTN	Factor: Fli-1; motif: NACCGGATATCCGGTN	76	0.006157	4
TF	TF:M09826_1	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1	58	0.006223	4
TF	TF:M01972	Factor: EGR-1; motif: TGCGTGGGCGK	Factor: EGR-1; motif: TGCGTGGGCGK	46	0.007258	4
TF	TF:M07039_1	Factor: ETF; motif: CCCCGCCCCYN; match class: 1	Factor: ETF; motif: CCCCGCCCCYN; match class: 1	82	0.008639	4
TF	TF:M03893_1	Factor: WT1; motif: GNGGGGGCGGGG; match class: 1	Factor: WT1; motif: GNGGGGGCGGGG; match class: 1	38	0.008801	4
TF	TF:M00244	Factor: NGFI-C; motif: WTGCGTGGGYGG	Factor: NGFI-C; motif: WTGCGTGGGYGG	50	0.008943	4
TF	TF:M12351	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC	77	0.009889	4
TF	TF:M01104_1	Factor: MOVO-B; motif: GNGGGGG; match class: 1	Factor: MOVO-B; motif: GNGGGGG; match class: 1	47	0.013266	4
TF	TF:M13147	Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN	Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN	72	0.014330	4
TF	TF:M09636_1	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1	83	0.019488	4
TF	TF:M07486_1	Factor: ZNF300; motif: SWGGGGGSN; match class: 1	Factor: ZNF300; motif: SWGGGGGSN; match class: 1	55	0.028260	4
TF	TF:M12160_1	Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1	Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1	58	0.035532	4
TF	TF:M12590	Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN	Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN	71	0.035687	4
TF	TF:M03893	Factor: WT1; motif: GNGGGGGCGGGG	Factor: WT1; motif: GNGGGGGCGGGG	59	0.039637	4
TF	TF:M02281	Factor: SP1; motif: CCCCKCCCCC	Factor: SP1; motif: CCCCKCCCCC	50	0.042298	4

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:2086	NFKB1-NFKB2-RELA-RELB complex	NFKB1-NFKB2-RELA-RELB complex	3	0.000650	4
CORUM	CORUM:2706	SMAD3-SMAD4-SP1 complex	SMAD3-SMAD4-SP1 complex	3	0.000650	4
CORUM	CORUM:2084	NFKB1-NFKB2-REL-RELA-RELB complex	NFKB1-NFKB2-REL-RELA-RELB complex	3	0.002577	4
CORUM	CORUM:3972	Ubiquitin E3 ligase (SMURF2, SMAD3) - SnoN complex, TGF(beta)-dependent	Ubiquitin E3 ligase (SMURF2, SMAD3) - SnoN complex, TGF(beta)-dependent	2	0.049979	4
CORUM	CORUM:3740	SKI-SMAD3-SMAD4 complex	SKI-SMAD3-SMAD4 complex	2	0.049979	4
CORUM	CORUM:3959	SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent	SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent	2	0.049979	4
CORUM	CORUM:2679	p53-SP1 complex	p53-SP1 complex	2	0.049979	4
CORUM	CORUM:2946	YY1-Notch1-RBP-Jkappa complex	YY1-Notch1-RBP-Jkappa complex	2	0.049979	4
CORUM	CORUM:2907	RBP-Jkappa-Notch1 complex	RBP-Jkappa-Notch1 complex	2	0.049979	4

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-200b-3p	hsa-mir-200b-3p	hsa-mir-200b-3p	8	0.001905	4
MIRNA	MIRNA:hsa-mir-145-5p	hsa-mir-145-5p	hsa-mir-145-5p	9	0.003596	4
MIRNA	MIRNA:hsa-mir-200c-3p	hsa-mir-200c-3p	hsa-mir-200c-3p	8	0.007729	4
MIRNA	MIRNA:hsa-mir-145-3p	hsa-mir-145-3p	hsa-mir-145-3p	5	0.014023	4
MIRNA	MIRNA:hsa-mir-29b-3p	hsa-mir-29b-3p	hsa-mir-29b-3p	8	0.029286	4
MIRNA	MIRNA:hsa-mir-6780b-5p	hsa-mir-6780b-5p	hsa-mir-6780b-5p	7	0.032751	4
MIRNA	MIRNA:hsa-mir-24-3p	hsa-mir-24-3p	hsa-mir-24-3p	14	0.042312	4
MIRNA	MIRNA:hsa-mir-18a-5p	hsa-mir-18a-5p	hsa-mir-18a-5p	8	0.042733	4

HP

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0010788	Testicular neoplasm	The presence of a neoplasm of the testis.	5	0.006693	4
HP	HP:0100848	Neoplasm of the male external genitalia	A tumor (abnormal growth of tissue) of the male external genitalia.	5	0.007800	4
HP	HP:0001581	Recurrent skin infections	Infections of the skin that happen multiple times.	8	0.015896	4
HP	HP:0010785	Gonadal neoplasm	A tumor (abnormal growth of tissue) of a gonad.	7	0.018313	4
HP	HP:0002088	Abnormal lung morphology	Any structural anomaly of the lung.	23	0.019671	4
HP	HP:0011122	Abnormality of skin physiology	Any abnormality of the physiological function of the skin.	15	0.028809	4
HP	HP:0011123	Inflammatory abnormality of the skin	The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes.	14	0.029432	4
HP	HP:0033151	Abnormal pharynx morphology	A structural anomaly of the pharynx.	9	0.041033	4
HP	HP:0000006	Autosomal dominant inheritance	A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.	29	0.042869	4

Community 5

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	14	8.386260e-11	5
GO:CC	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	11	3.085358e-09	5
GO:CC	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	22	7.000154e-09	5
GO:CC	GO:0030863	cortical cytoskeleton	"The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah]	8	9.611634e-09	5
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	20	3.001856e-08	5
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	20	3.869229e-08	5
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	20	3.901833e-08	5
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	20	3.901833e-08	5
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	26	4.500388e-08	5
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	20	2.984991e-07	5
GO:CC	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	7	6.016350e-07	5
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	13	1.237946e-06	5
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	22	2.044844e-06	5
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	30	3.666608e-06	5
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	30	3.680693e-06	5
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	9	1.535299e-05	5
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	9	1.870767e-05	5
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	26	5.035501e-05	5
GO:CC	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	17	6.204221e-05	5
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	38	8.516804e-05	5
GO:CC	GO:0030864	cortical actin cytoskeleton	"The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]	5	1.134067e-04	5
GO:CC	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917]	17	1.264491e-04	5
GO:CC	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	6	1.434635e-04	5
GO:CC	GO:0030427	site of polarized growth	"Any part of a cell where non-isotropic growth takes place." [GOC:mah]	6	1.703565e-04	5
GO:CC	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	22	2.045993e-04	5
GO:CC	GO:0097136	Bcl-2 family protein complex	"A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed." [GOC:so, PMID:14634621]	3	2.195035e-04	5
GO:CC	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	13	2.457838e-04	5
GO:CC	GO:0099080	supramolecular complex	"A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]	12	1.773959e-03	5
GO:CC	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	22	2.145673e-03	5
GO:CC	GO:0150034	distal axon	"That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468]	6	2.794564e-03	5
GO:CC	GO:0098862	cluster of actin-based cell projections	"A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos]	5	3.635103e-03	5
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	41	3.760932e-03	5
GO:CC	GO:0099512	supramolecular fiber	"A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos]	10	4.248228e-03	5
GO:CC	GO:0099081	supramolecular polymer	"A polymeric supramolecular structure." [GOC:dos]	10	4.530939e-03	5
GO:CC	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	9	6.354303e-03	5
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	40	8.637482e-03	5
GO:CC	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	7	1.043156e-02	5
GO:CC	GO:0005903	brush border	"The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194]	4	1.155639e-02	5
GO:CC	GO:0002102	podosome	"An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982]	3	1.364445e-02	5
GO:CC	GO:0072357	PTW/PP1 phosphatase complex	"A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061]	2	1.593493e-02	5
GO:CC	GO:0099513	polymeric cytoskeletal fiber	"A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos]	8	2.556105e-02	5
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	14	2.776835e-02	5
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	14	2.848254e-02	5
GO:CC	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060]	10	3.171892e-02	5
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	11	3.668037e-02	5
GO:CC	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	3	3.864142e-02	5
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	41	4.035744e-02	5
GO:CC	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	7	4.253563e-02	5
GO:CC	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	23	4.826844e-02	5

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	12	4.287881e-07	5
GO:MF	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	8	4.208767e-06	5
GO:MF	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	10	7.480930e-06	5
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	9	9.842911e-06	5
GO:MF	GO:0051434	BH3 domain binding	"Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259]	3	7.064315e-05	5
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	17	1.569663e-04	5
GO:MF	GO:0051400	BH domain binding	"Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409]	3	7.703641e-04	5
GO:MF	GO:0070513	death domain binding	"Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]	3	1.000027e-03	5
GO:MF	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	10	1.671720e-03	5
GO:MF	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	11	1.818409e-03	5
GO:MF	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	12	4.050944e-03	5
GO:MF	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	9	5.562141e-03	5
GO:MF	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	7	7.427802e-03	5
GO:MF	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	8	2.191287e-02	5
GO:MF	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	9	2.263056e-02	5
GO:MF	GO:0000146	microfilament motor activity	"A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949]	3	2.624301e-02	5
GO:MF	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	5	2.910599e-02	5
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	41	3.067614e-02	5
GO:MF	GO:0140678	molecular function inhibitor activity	"A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	7	4.118064e-02	5

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0097435	supramolecular fiber organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr]	13	0.000009	5
GO:BP	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	23	0.000033	5
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	23	0.000047	5
GO:BP	GO:0030029	actin filament-based process	"Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]	12	0.000063	5
GO:BP	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	15	0.000151	5
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	21	0.000166	5
GO:BP	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	11	0.000183	5
GO:BP	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	9	0.000377	5
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	19	0.000440	5
GO:BP	GO:0030048	actin filament-based movement	"Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]	6	0.000453	5
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	19	0.000471	5
GO:BP	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	12	0.000586	5
GO:BP	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	28	0.000739	5
GO:BP	GO:0009895	negative regulation of catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	8	0.000754	5
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	12	0.000777	5
GO:BP	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	16	0.000973	5
GO:BP	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	20	0.003170	5
GO:BP	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	31	0.003599	5
GO:BP	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	26	0.004985	5
GO:BP	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	10	0.005387	5
GO:BP	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	25	0.006196	5
GO:BP	GO:0071840	cellular component organization or biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]	31	0.006750	5
GO:BP	GO:1903921	regulation of protein processing in phagocytic vesicle	"Any process that modulates the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]	2	0.006870	5
GO:BP	GO:1903923	positive regulation of protein processing in phagocytic vesicle	"Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]	2	0.006870	5
GO:BP	GO:1900756	protein processing in phagocytic vesicle	"Protein processing that takes place in the phagosome. Most protein processing in the phagosome represents protein degradation." [GOC:rjd, GOC:TermGenie]	2	0.006870	5
GO:BP	GO:1904780	negative regulation of protein localization to centrosome	"Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]	2	0.006870	5
GO:BP	GO:1903729	regulation of plasma membrane organization	"Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900]	3	0.007012	5
GO:BP	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	9	0.007213	5
GO:BP	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	25	0.008033	5
GO:BP	GO:0097191	extrinsic apoptotic signaling pathway	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]	6	0.009704	5
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	14	0.010922	5
GO:BP	GO:0051293	establishment of spindle localization	"The directed movement of the spindle to a specific location in the cell." [GOC:ai]	4	0.012627	5
GO:BP	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	10	0.013026	5
GO:BP	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	9	0.013202	5
GO:BP	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	19	0.015478	5
GO:BP	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	25	0.016102	5
GO:BP	GO:0051653	spindle localization	"Any process in which is the spindle is transported to, and/or maintained in, a specific location." [GOC:ai]	4	0.017143	5
GO:BP	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	4	0.019247	5
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	12	0.019573	5
GO:BP	GO:0046604	positive regulation of mitotic centrosome separation	"Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai]	2	0.020585	5
GO:BP	GO:0038034	signal transduction in absence of ligand	"The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor." [GOC:al, GOC:ppm, GOC:pr, PMID:15044679]	4	0.021535	5
GO:BP	GO:2001236	regulation of extrinsic apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	5	0.023583	5
GO:BP	GO:0008219	cell death	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]	14	0.024747	5
GO:BP	GO:0010954	positive regulation of protein processing	"Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]	3	0.025070	5
GO:BP	GO:0030010	establishment of cell polarity	"The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	5	0.025861	5
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	14	0.027590	5
GO:BP	GO:0048284	organelle fusion	"The creation of a single organelle from two or more organelles." [GOC:jid]	5	0.030929	5
GO:BP	GO:0009056	catabolic process	"A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	16	0.031144	5
GO:BP	GO:1903319	positive regulation of protein maturation	"Any process that activates or increases the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	3	0.032117	5
GO:BP	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	10	0.033578	5
GO:BP	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	36	0.035816	5
GO:BP	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	4	0.039712	5
GO:BP	GO:2000295	regulation of hydrogen peroxide catabolic process	"Any process that modulates the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF]	2	0.041118	5
GO:BP	GO:1904019	epithelial cell apoptotic process	"Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015]	4	0.041615	5
GO:BP	GO:0044042	glucan metabolic process	"The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl]	4	0.043583	5
GO:BP	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	15	0.048384	5

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-5627123	RHO GTPases activate PAKs	RHO GTPases activate PAKs	4	0.000081	5
REAC	REAC:R-HSA-194315	Signaling by Rho GTPases	Signaling by Rho GTPases	10	0.002435	5
REAC	REAC:R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	10	0.002940	5
REAC	REAC:R-HSA-162582	Signal Transduction	Signal Transduction	17	0.015875	5

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP3872	Apoptosis regulation by parathyroid hormone related protein	Apoptosis regulation by parathyroid hormone related protein	4	0.000216	5
WP	WP:WP5426	HDAC6 interactions in the central nervous system	HDAC6 interactions in the central nervous system	6	0.000386	5
WP	WP:WP4659	Gastrin signaling	Gastrin signaling	5	0.007590	5
WP	WP:WP4864	Host pathogen interaction of human coronaviruses apoptosis	Host pathogen interaction of human coronaviruses apoptosis	3	0.008209	5
WP	WP:WP3614	Photodynamic therapy induced HIF 1 survival signaling	Photodynamic therapy induced HIF 1 survival signaling	3	0.046088	5

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0460202	Skin 1; endothelial cells[≥Medium]	Skin 1; endothelial cells[≥Medium]	10	0.001991	5
HPA	HPA:0460203	Skin 1; endothelial cells[High]	Skin 1; endothelial cells[High]	7	0.009916	5
HPA	HPA:0460201	Skin 1; endothelial cells[≥Low]	Skin 1; endothelial cells[≥Low]	10	0.039366	5

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:05205	Proteoglycans in cancer	Proteoglycans in cancer	6	0.002814	5
KEGG	KEGG:05130	Pathogenic Escherichia coli infection	Pathogenic Escherichia coli infection	5	0.025700	5
KEGG	KEGG:04810	Regulation of actin cytoskeleton	Regulation of actin cytoskeleton	5	0.049092	5

Community 6

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:6823	CP–LF–MPO complex	CP–LF–MPO complex	2	0.000132	6

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0097013	phagocytic vesicle lumen	"The volume enclosed by the membrane of a phagocytic vesicle." [GOC:rs]	2	0.000483	6
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	8	0.001552	6
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	8	0.001724	6
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	8	0.001730	6
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	8	0.001730	6
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	9	0.004742	6
GO:CC	GO:0034774	secretory granule lumen	"The volume enclosed by the membrane of a secretory granule." [GOC:rph]	4	0.005155	6
GO:CC	GO:0060205	cytoplasmic vesicle lumen	"The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles]	4	0.005474	6
GO:CC	GO:0031983	vesicle lumen	"The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles]	4	0.005539	6
GO:CC	GO:0071682	endocytic vesicle lumen	"The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde]	2	0.012130	6
GO:CC	GO:0045335	phagocytic vesicle	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]	3	0.012866	6
GO:CC	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	5	0.021793	6
GO:CC	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	9	0.036140	6

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-6803157	Antimicrobial peptides	Antimicrobial peptides	4	0.000769	6
REAC	REAC:R-HSA-6799990	Metal sequestration by antimicrobial proteins	Metal sequestration by antimicrobial proteins	2	0.004914	6

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0042742	defense response to bacterium	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]	5	0.000883	6
GO:BP	GO:0098542	defense response to other organism	"Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]	7	0.002157	6
GO:BP	GO:0050832	defense response to fungus	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]	3	0.005814	6
GO:BP	GO:0009620	response to fungus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]	3	0.009755	6
GO:BP	GO:0051707	response to other organism	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai]	7	0.010180	6
GO:BP	GO:0043207	response to external biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators]	7	0.010308	6
GO:BP	GO:0009607	response to biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]	7	0.012106	6
GO:BP	GO:0140546	defense response to symbiont	"Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg]	6	0.016597	6
GO:BP	GO:0044419	biological process involved in interspecies interaction between organisms	"Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]	7	0.019743	6
GO:BP	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	7	0.027849	6
GO:BP	GO:0050829	defense response to Gram-negative bacterium	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]	3	0.028539	6
GO:BP	GO:0009617	response to bacterium	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]	5	0.040695	6
GO:BP	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	8	0.045443	6

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04970	Salivary secretion	Salivary secretion	3	0.001966	6

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0471402	Skin 2; cells in corneal layer[≥Medium]	Skin 2; cells in corneal layer[≥Medium]	3	0.010672	6
HPA	HPA:0471401	Skin 2; cells in corneal layer[≥Low]	Skin 2; cells in corneal layer[≥Low]	3	0.037919	6

washu+biogrid+hippie (Leiden)

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washu+biogrid+hippie (Louvain)

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Community 0

GO:BP

source	term_id	annotation	description	intersection_size	p_value
GO:BP	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	138	4.846490e-34
GO:BP	GO:0051253	negative regulation of RNA metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	72	1.126667e-30
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	"Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	74	5.640708e-30
GO:BP	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	105	1.059426e-28
GO:BP	GO:0051252	regulation of RNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	109	1.113018e-28
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	67	1.484693e-28
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	"Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	113	1.667159e-28
GO:BP	GO:2001141	regulation of RNA biosynthetic process	"Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]	105	1.727780e-28
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	"Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	67	3.132244e-28
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	102	8.627662e-28
GO:BP	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	106	2.122144e-27
GO:BP	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	105	3.596738e-27
GO:BP	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	130	6.627037e-26
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	"Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	78	4.365104e-25
GO:BP	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	131	5.801710e-25
GO:BP	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	41	1.182125e-24
GO:BP	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	99	1.201737e-24
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	62	1.354925e-24
GO:BP	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	143	2.793776e-24
GO:BP	GO:0009891	positive regulation of biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	88	3.452868e-24
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	86	4.062825e-24
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	95	4.300528e-24
GO:BP	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	137	4.379839e-24
GO:BP	GO:0051254	positive regulation of RNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	73	4.711902e-24
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	70	9.551135e-24
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	70	1.025099e-23
GO:BP	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	87	2.758183e-23
GO:BP	GO:0009889	regulation of biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	128	4.014722e-23
GO:BP	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	124	1.461941e-22
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	"Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	84	1.751705e-22
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	"Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	125	2.149757e-22
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	52	3.302300e-22
GO:BP	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	80	3.370629e-21
GO:BP	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	130	4.169136e-21
GO:BP	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	126	5.288781e-21
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	"Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	84	8.629569e-21
GO:BP	GO:0045595	regulation of cell differentiation	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]	63	4.395319e-20
GO:BP	GO:0009890	negative regulation of biosynthetic process	"Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	84	4.507464e-20
GO:BP	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	106	1.209507e-19
GO:BP	GO:0048869	cellular developmental process	"A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]	106	1.232041e-19
GO:BP	GO:0030111	regulation of Wnt signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]	32	1.278034e-19
GO:BP	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	31	2.534222e-19
GO:BP	GO:0048583	regulation of response to stimulus	"Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	99	6.809353e-19
GO:BP	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	63	1.280653e-18
GO:BP	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	123	1.294183e-18
GO:BP	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	129	1.533898e-18
GO:BP	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	176	1.285231e-17
GO:BP	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	80	2.228604e-17
GO:BP	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	83	2.949544e-17
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	"Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb]	27	3.409753e-17
GO:BP	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	151	3.702382e-17
GO:BP	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	89	4.755156e-17
GO:BP	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	89	5.559685e-17
GO:BP	GO:0023057	negative regulation of signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	56	7.551504e-17
GO:BP	GO:0010648	negative regulation of cell communication	"Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	56	7.800709e-17
GO:BP	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	177	2.531089e-16
GO:BP	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	125	2.699383e-16
GO:BP	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	119	2.963937e-16
GO:BP	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	53	3.465785e-16
GO:BP	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	124	6.922848e-16
GO:BP	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	76	7.332016e-16
GO:BP	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	133	7.565857e-16
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	62	1.023570e-15
GO:BP	GO:0051093	negative regulation of developmental process	"Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	44	1.190600e-15
GO:BP	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	55	2.680970e-15
GO:BP	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	178	5.346428e-15
GO:BP	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	37	9.506811e-15
GO:BP	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	63	2.054944e-14
GO:BP	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	79	2.212608e-14
GO:BP	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	77	3.222817e-14
GO:BP	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	59	5.180762e-13
GO:BP	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	98	5.683524e-13
GO:BP	GO:2000628	regulation of miRNA metabolic process	"Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph]	16	6.158258e-13
GO:BP	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	88	7.276453e-13
GO:BP	GO:1902893	regulation of miRNA transcription	"Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]	15	1.020281e-12
GO:BP	GO:0061614	miRNA transcription	"The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799]	15	1.256543e-12
GO:BP	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	59	2.300170e-12
GO:BP	GO:0008219	cell death	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]	59	2.519251e-12
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	"Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph]	14	2.661728e-12
GO:BP	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	44	3.190911e-12
GO:BP	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	72	4.317132e-12
GO:BP	GO:0141124	intracellular signaling cassette	"An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg]	57	6.933392e-12
GO:BP	GO:0010586	miRNA metabolic process	"The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]	16	9.251621e-12
GO:BP	GO:0051094	positive regulation of developmental process	"Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	47	9.858969e-12
GO:BP	GO:1902895	positive regulation of miRNA transcription	"Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]	13	1.259724e-11
GO:BP	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	41	1.439484e-11
GO:BP	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	63	1.527008e-11
GO:BP	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	52	2.778903e-11
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	33	4.749958e-11
GO:BP	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	44	5.131151e-11
GO:BP	GO:0048732	gland development	"The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]	27	7.387653e-11
GO:BP	GO:0009719	response to endogenous stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]	48	1.055516e-10
GO:BP	GO:0043009	chordate embryonic development	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu]	32	1.225527e-10
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	18	1.240131e-10
GO:BP	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	51	1.661556e-10
GO:BP	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	47	2.278558e-10
GO:BP	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	36	2.288494e-10
GO:BP	GO:0044093	positive regulation of molecular function	"Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]	36	3.208923e-10
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	39	3.681882e-10
GO:BP	GO:0035295	tube development	"The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]	40	4.738070e-10
GO:BP	GO:0031399	regulation of protein modification process	"Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	39	4.827970e-10
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	16	6.424433e-10
GO:BP	GO:0043069	negative regulation of programmed cell death	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	36	6.425259e-10
GO:BP	GO:0043067	regulation of programmed cell death	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	47	6.679172e-10
GO:BP	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	83	1.170187e-09
GO:BP	GO:0044092	negative regulation of molecular function	"Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]	28	1.251019e-09
GO:BP	GO:0051090	regulation of DNA-binding transcription factor activity	"Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	22	1.260310e-09
GO:BP	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	38	1.301461e-09
GO:BP	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	45	1.340748e-09
GO:BP	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	35	1.395036e-09
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	41	1.617437e-09
GO:BP	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	68	2.250038e-09
GO:BP	GO:0071495	cellular response to endogenous stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]	41	3.057629e-09
GO:BP	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	54	3.389289e-09
GO:BP	GO:1902531	regulation of intracellular signal transduction	"Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	53	3.574191e-09
GO:BP	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	119	3.732175e-09
GO:BP	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	51	3.924550e-09
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	90	4.184929e-09
GO:BP	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	39	5.567411e-09
GO:BP	GO:0033993	response to lipid	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]	35	6.925161e-09
GO:BP	GO:0010647	positive regulation of cell communication	"Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	50	7.002618e-09
GO:BP	GO:0023056	positive regulation of signaling	"Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	50	7.147851e-09
GO:BP	GO:0007507	heart development	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]	28	1.075290e-08
GO:BP	GO:0030177	positive regulation of Wnt signaling pathway	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]	15	1.732544e-08
GO:BP	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	35	2.672105e-08
GO:BP	GO:0070887	cellular response to chemical stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]	55	2.672729e-08
GO:BP	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	34	3.055145e-08
GO:BP	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	33	3.323478e-08
GO:BP	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	78	3.535109e-08
GO:BP	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	36	3.761799e-08
GO:BP	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	64	3.820404e-08
GO:BP	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	39	4.068961e-08
GO:BP	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	45	5.063578e-08
GO:BP	GO:0048863	stem cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]	18	5.199982e-08
GO:BP	GO:0034097	response to cytokine	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl]	34	5.284399e-08
GO:BP	GO:0045667	regulation of osteoblast differentiation	"Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]	14	6.140275e-08
GO:BP	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	38	7.908720e-08
GO:BP	GO:1901652	response to peptide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]	34	8.062415e-08
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	42	8.093549e-08
GO:BP	GO:0016070	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	111	9.291871e-08
GO:BP	GO:0141187	nucleic acid biosynthetic process	"The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb]	110	9.607437e-08
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	113	1.056575e-07
GO:BP	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]	162	1.069995e-07
GO:BP	GO:0009056	catabolic process	"A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	60	1.359497e-07
GO:BP	GO:0032774	RNA biosynthetic process	"The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]	108	2.063613e-07
GO:BP	GO:0001649	osteoblast differentiation	"The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid]	17	2.250838e-07
GO:BP	GO:0048511	rhythmic process	"Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid]	19	2.474622e-07
GO:BP	GO:0061061	muscle structure development	"The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]	28	2.539097e-07
GO:BP	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	32	3.397133e-07
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	121	3.835780e-07
GO:BP	GO:0048729	tissue morphogenesis	"The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid]	26	4.523909e-07
GO:BP	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	35	5.041327e-07
GO:BP	GO:0090304	nucleic acid metabolic process	"Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb]	115	5.141553e-07
GO:BP	GO:0043412	macromolecule modification	"The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]	64	5.577544e-07
GO:BP	GO:0060767	epithelial cell proliferation involved in prostate gland development	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph]	6	6.000114e-07
GO:BP	GO:0051248	negative regulation of protein metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]	27	7.454010e-07
GO:BP	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	20	9.258763e-07
GO:BP	GO:0002521	leukocyte differentiation	"The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264]	26	9.599541e-07
GO:BP	GO:0001701	in utero embryonic development	"The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu]	21	1.065206e-06
GO:BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	21	1.112803e-06
GO:BP	GO:0060284	regulation of cell development	"Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]	30	1.231030e-06
GO:BP	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	30	1.494351e-06
GO:BP	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	25	1.764460e-06
GO:BP	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	38	1.848585e-06
GO:BP	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	34	1.994659e-06
GO:BP	GO:0001503	ossification	"The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649]	21	2.201611e-06
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	26	2.240058e-06
GO:BP	GO:0048589	developmental growth	"The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]	26	2.312283e-06
GO:BP	GO:0002682	regulation of immune system process	"Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]	42	2.330681e-06
GO:BP	GO:0007389	pattern specification process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]	22	2.513934e-06
GO:BP	GO:0040007	growth	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]	31	2.601985e-06
GO:BP	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	36	3.332205e-06
GO:BP	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	156	3.750513e-06
GO:BP	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	54	4.087546e-06
GO:BP	GO:0009895	negative regulation of catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	19	4.170793e-06
GO:BP	GO:0019220	regulation of phosphate metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	31	5.143418e-06
GO:BP	GO:0051174	regulation of phosphorus metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]	31	5.272228e-06
GO:BP	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	23	5.290559e-06
GO:BP	GO:0051338	regulation of transferase activity	"Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai]	22	5.560532e-06
GO:BP	GO:0002009	morphogenesis of an epithelium	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]	22	6.676108e-06
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194]	31	7.248781e-06
GO:BP	GO:0080134	regulation of response to stress	"Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	38	7.257390e-06
GO:BP	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	26	8.557323e-06
GO:BP	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	42	1.115982e-05
GO:BP	GO:0003007	heart morphogenesis	"The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]	16	1.242897e-05
GO:BP	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	11	1.257651e-05
GO:BP	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	14	1.280271e-05
GO:BP	GO:0035282	segmentation	"The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689]	11	1.388625e-05
GO:BP	GO:0042325	regulation of phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]	28	1.407013e-05
GO:BP	GO:0051148	negative regulation of muscle cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]	9	1.411215e-05
GO:BP	GO:0003002	regionalization	"The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete]	20	1.437463e-05
GO:BP	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	55	1.629878e-05
GO:BP	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	24	1.736745e-05
GO:BP	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	27	1.836139e-05
GO:BP	GO:0043434	response to peptide hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]	20	1.881854e-05
GO:BP	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	30	1.924083e-05
GO:BP	GO:0050673	epithelial cell proliferation	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544]	20	1.954831e-05
GO:BP	GO:0009607	response to biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]	41	1.981331e-05
GO:BP	GO:0051145	smooth muscle cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai]	9	2.169181e-05
GO:BP	GO:0019941	modification-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]	24	2.351494e-05
GO:BP	GO:0098542	defense response to other organism	"Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]	35	2.494253e-05
GO:BP	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	52	2.516602e-05
GO:BP	GO:0062012	regulation of small molecule metabolic process	"Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]	17	2.634893e-05
GO:BP	GO:0030855	epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]	26	2.640250e-05
GO:BP	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	44	2.656381e-05
GO:BP	GO:0043632	modification-dependent macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl]	24	2.729875e-05
GO:BP	GO:0051707	response to other organism	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai]	40	2.999376e-05
GO:BP	GO:0007517	muscle organ development	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]	18	3.080296e-05
GO:BP	GO:0007623	circadian rhythm	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]	14	3.089178e-05
GO:BP	GO:0043207	response to external biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators]	40	3.159684e-05
GO:BP	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development	"Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph]	5	3.495482e-05
GO:BP	GO:0001889	liver development	"The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X]	12	3.560667e-05
GO:BP	GO:0048568	embryonic organ development	"Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	20	4.397053e-05
GO:BP	GO:0061008	hepaticobiliary system development	"The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph]	12	4.467121e-05
GO:BP	GO:0071396	cellular response to lipid	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah]	23	5.071943e-05
GO:BP	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	17	5.162631e-05
GO:BP	GO:0030850	prostate gland development	"The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751]	8	5.227756e-05
GO:BP	GO:0044419	biological process involved in interspecies interaction between organisms	"Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]	42	5.237139e-05
GO:BP	GO:0060562	epithelial tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph]	17	5.392319e-05
GO:BP	GO:0045670	regulation of osteoclast differentiation	"Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]	9	5.450421e-05
GO:BP	GO:0048663	neuron fate commitment	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph]	9	6.165651e-05
GO:BP	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	23	6.241924e-05
GO:BP	GO:0001932	regulation of protein phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]	26	6.305521e-05
GO:BP	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	42	6.348910e-05
GO:BP	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	127	6.937966e-05
GO:BP	GO:0060537	muscle tissue development	"The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]	19	7.024151e-05
GO:BP	GO:0043549	regulation of kinase activity	"Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf]	19	7.286761e-05
GO:BP	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	57	7.301844e-05
GO:BP	GO:0009952	anterior/posterior pattern specification	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	14	7.375011e-05
GO:BP	GO:0003170	heart valve development	"The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart]	9	7.845617e-05
GO:BP	GO:1901698	response to nitrogen compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	31	8.625431e-05
GO:BP	GO:0007049	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]	40	9.895184e-05
GO:BP	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	23	1.020434e-04
GO:BP	GO:0000165	MAPK cascade	"An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]	25	1.040996e-04
GO:BP	GO:0002237	response to molecule of bacterial origin	"Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm]	17	1.298716e-04
GO:BP	GO:0045859	regulation of protein kinase activity	"Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	18	1.336333e-04
GO:BP	GO:0009896	positive regulation of catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	21	1.400833e-04
GO:BP	GO:0048565	digestive tract development	"The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]	11	1.437797e-04
GO:BP	GO:0042692	muscle cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators]	18	1.494060e-04
GO:BP	GO:0009059	macromolecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	130	1.524713e-04
GO:BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	"Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	14	1.564854e-04
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	"Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb]	16	1.645022e-04
GO:BP	GO:0001944	vasculature development	"The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409]	25	1.645114e-04
GO:BP	GO:0002573	myeloid leukocyte differentiation	"The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251]	14	1.647909e-04
GO:BP	GO:0014706	striated muscle tissue development	"The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle]	18	1.668681e-04
GO:BP	GO:0045444	fat cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators]	14	1.734925e-04
GO:BP	GO:0043085	positive regulation of catalytic activity	"Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	21	1.788351e-04
GO:BP	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419]	25	1.909999e-04
GO:BP	GO:1901873	regulation of post-translational protein modification	"Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]	14	2.021453e-04
GO:BP	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	13	2.167072e-04
GO:BP	GO:0009058	biosynthetic process	"A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	139	2.274941e-04
GO:BP	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	13	2.291522e-04
GO:BP	GO:0070848	response to growth factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah]	24	2.333729e-04
GO:BP	GO:0031669	cellular response to nutrient levels	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]	14	2.469834e-04
GO:BP	GO:0002683	negative regulation of immune system process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]	20	2.495043e-04
GO:BP	GO:1902105	regulation of leukocyte differentiation	"Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]	16	2.503996e-04
GO:BP	GO:0009617	response to bacterium	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]	24	2.786419e-04
GO:BP	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	12	2.786761e-04
GO:BP	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	37	2.968786e-04
GO:BP	GO:0071216	cellular response to biotic stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah]	14	3.006095e-04
GO:BP	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	18	3.063743e-04
GO:BP	GO:0043086	negative regulation of catalytic activity	"Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	15	3.110292e-04
GO:BP	GO:0055123	digestive system development	"The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid]	11	3.206851e-04
GO:BP	GO:0032496	response to lipopolysaccharide	"Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464]	16	3.606764e-04
GO:BP	GO:0045165	cell fate commitment	"The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]	15	3.704410e-04
GO:BP	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	26	3.745349e-04
GO:BP	GO:0042594	response to starvation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]	13	3.938263e-04
GO:BP	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	23	4.144190e-04
GO:BP	GO:0008152	metabolic process	"A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	168	4.292434e-04
GO:BP	GO:1903131	mononuclear cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906]	20	4.451125e-04
GO:BP	GO:0032870	cellular response to hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah]	22	4.464815e-04
GO:BP	GO:0001756	somitogenesis	"The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544]	8	4.695516e-04
GO:BP	GO:0001890	placenta development	"The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]	11	4.825209e-04
GO:BP	GO:0033173	calcineurin-NFAT signaling cascade	"Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+)." [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679]	7	4.912465e-04
GO:BP	GO:0001655	urogenital system development	"The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators]	8	5.278092e-04
GO:BP	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	8	5.278092e-04
GO:BP	GO:0031400	negative regulation of protein modification process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	16	5.335911e-04
GO:BP	GO:0060541	respiratory system development	"The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph]	13	5.374724e-04
GO:BP	GO:0038061	non-canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217]	10	5.376559e-04
GO:BP	GO:0014888	striated muscle adaptation	"Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]	7	5.725458e-04
GO:BP	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	15	5.904701e-04
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	"Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]	14	6.363428e-04
GO:BP	GO:0034612	response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	13	6.576877e-04
GO:BP	GO:0045669	positive regulation of osteoblast differentiation	"Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]	8	6.630941e-04
GO:BP	GO:0097720	calcineurin-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544]	7	6.648762e-04
GO:BP	GO:0002761	regulation of myeloid leukocyte differentiation	"Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]	10	6.748903e-04
GO:BP	GO:0097193	intrinsic apoptotic signaling pathway	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]	15	6.960391e-04
GO:BP	GO:0030162	regulation of proteolysis	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]	17	8.035777e-04
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	"Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]	25	8.361353e-04
GO:BP	GO:0031396	regulation of protein ubiquitination	"Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	12	8.861677e-04
GO:BP	GO:0034504	protein localization to nucleus	"A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]	15	8.865311e-04
GO:BP	GO:0009798	axis specification	"The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete]	9	8.866737e-04
GO:BP	GO:0030324	lung development	"The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048]	12	9.354841e-04
GO:BP	GO:0050678	regulation of epithelial cell proliferation	"Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai]	16	9.359772e-04
GO:BP	GO:0022612	gland morphogenesis	"The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete]	10	9.724211e-04
GO:BP	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	43	9.810797e-04
GO:BP	GO:0071354	cellular response to interleukin-6	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah]	6	9.947057e-04
GO:BP	GO:0061323	cell proliferation involved in heart morphogenesis	"The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart]	5	1.116321e-03
GO:BP	GO:2000136	regulation of cell proliferation involved in heart morphogenesis	"Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]	5	1.116321e-03
GO:BP	GO:0006793	phosphorus metabolic process	"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]	48	1.123643e-03
GO:BP	GO:0030323	respiratory tube development	"The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid]	12	1.158046e-03
GO:BP	GO:0045598	regulation of fat cell differentiation	"Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]	10	1.201372e-03
GO:BP	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	35	1.282021e-03
GO:BP	GO:0003205	cardiac chamber development	"The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]	11	1.396207e-03
GO:BP	GO:0043500	muscle adaptation	"A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]	9	1.464802e-03
GO:BP	GO:0042742	defense response to bacterium	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]	15	1.526003e-03
GO:BP	GO:0006954	inflammatory response	"The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732]	25	1.634633e-03
GO:BP	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	21	1.761219e-03
GO:BP	GO:0030879	mammary gland development	"The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833]	10	1.804348e-03
GO:BP	GO:0031347	regulation of defense response	"Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah]	24	1.853158e-03
GO:BP	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	9	1.859927e-03
GO:BP	GO:0003279	cardiac septum development	"The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]	9	1.859927e-03
GO:BP	GO:0045637	regulation of myeloid cell differentiation	"Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]	12	2.031112e-03
GO:BP	GO:0046649	lymphocyte activation	"A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]	24	2.065010e-03
GO:BP	GO:0051150	regulation of smooth muscle cell differentiation	"Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]	6	2.070747e-03
GO:BP	GO:1902806	regulation of cell cycle G1/S phase transition	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]	11	2.086171e-03
GO:BP	GO:0030316	osteoclast differentiation	"The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749]	9	2.171797e-03
GO:BP	GO:0051147	regulation of muscle cell differentiation	"Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]	10	2.194561e-03
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:22651914, PMID:28096268]	15	2.377110e-03
GO:BP	GO:0070741	response to interleukin-6	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah]	6	2.451861e-03
GO:BP	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	29	2.547973e-03
GO:BP	GO:0030098	lymphocyte differentiation	"The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators]	17	2.589092e-03
GO:BP	GO:0045862	positive regulation of proteolysis	"Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]	12	2.592419e-03
GO:BP	GO:0030099	myeloid cell differentiation	"The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149]	17	2.669897e-03
GO:BP	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	47	2.672323e-03
GO:BP	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	26	2.696307e-03
GO:BP	GO:0001708	cell fate specification	"The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate." [GOC:go_curators]	9	2.724004e-03
GO:BP	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	9	2.724004e-03
GO:BP	GO:0048699	generation of neurons	"The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]	35	2.743465e-03
GO:BP	GO:0042752	regulation of circadian rhythm	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]	9	2.933168e-03
GO:BP	GO:0061053	somite development	"The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph]	8	2.989033e-03
GO:BP	GO:0035148	tube formation	"Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf]	10	3.200971e-03
GO:BP	GO:0140546	defense response to symbiont	"Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg]	28	3.255839e-03
GO:BP	GO:0010564	regulation of cell cycle process	"Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	22	3.352106e-03
GO:BP	GO:0010721	negative regulation of cell development	"Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]	13	3.701314e-03
GO:BP	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	27	3.779795e-03
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]	19	3.925219e-03
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	19	3.925219e-03
GO:BP	GO:0003179	heart valve morphogenesis	"The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart]	7	3.964039e-03
GO:BP	GO:0016331	morphogenesis of embryonic epithelium	"The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl]	10	4.076701e-03
GO:BP	GO:0031667	response to nutrient levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]	18	4.249851e-03
GO:BP	GO:0001568	blood vessel development	"The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981]	22	4.384525e-03
GO:BP	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	28	4.397615e-03
GO:BP	GO:0044843	cell cycle G1/S phase transition	"The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle]	12	4.534276e-03
GO:BP	GO:0070647	protein modification by small protein conjugation or removal	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah]	26	4.599900e-03
GO:BP	GO:0007178	cell surface receptor protein serine/threonine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	15	4.772847e-03
GO:BP	GO:0072497	mesenchymal stem cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0002452, GOC:BHF]	4	4.793732e-03
GO:BP	GO:0072091	regulation of stem cell proliferation	"Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]	8	5.025321e-03
GO:BP	GO:0030217	T cell differentiation	"The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah]	14	5.028487e-03
GO:BP	GO:0014898	cardiac muscle hypertrophy in response to stress	"The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]	5	5.284075e-03
GO:BP	GO:0014887	cardiac muscle adaptation	"The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle]	5	5.284075e-03
GO:BP	GO:0003299	muscle hypertrophy in response to stress	"The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart]	5	5.284075e-03
GO:BP	GO:0072089	stem cell proliferation	"The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]	9	5.528585e-03
GO:BP	GO:1903050	regulation of proteolysis involved in protein catabolic process	"Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]	12	5.918612e-03
GO:BP	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	33	5.981795e-03
GO:BP	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [PMID:26906419]	13	6.245443e-03
GO:BP	GO:0061136	regulation of proteasomal protein catabolic process	"Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb]	11	6.264240e-03
GO:BP	GO:0042110	T cell activation	"The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149]	19	6.866556e-03
GO:BP	GO:0003231	cardiac ventricle development	"The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]	9	7.203773e-03
GO:BP	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	34	7.284321e-03
GO:BP	GO:0035567	non-canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin." [PMID:37804416]	7	7.443057e-03
GO:BP	GO:2001233	regulation of apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	15	8.055756e-03
GO:BP	GO:0060411	cardiac septum morphogenesis	"The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart]	7	8.216546e-03
GO:BP	GO:0071772	response to BMP	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf]	10	8.519546e-03
GO:BP	GO:0071773	cellular response to BMP stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf]	10	8.519546e-03
GO:BP	GO:0051169	nuclear transport	"The directed movement of substances into, out of, or within the nucleus." [GOC:ai]	14	8.549034e-03
GO:BP	GO:0006913	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	14	8.549034e-03
GO:BP	GO:0043433	negative regulation of DNA-binding transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl]	9	8.730507e-03
GO:BP	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	10	8.990775e-03
GO:BP	GO:0048645	animal organ formation	"The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid]	7	9.055819e-03
GO:BP	GO:0032088	negative regulation of NF-kappaB transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb]	7	9.055819e-03
GO:BP	GO:1903322	positive regulation of protein modification by small protein conjugation or removal	"Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	9	9.297539e-03
GO:BP	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	30	9.884404e-03
GO:BP	GO:1901875	positive regulation of post-translational protein modification	"Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]	9	9.895872e-03
GO:BP	GO:0032101	regulation of response to external stimulus	"Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	27	9.949547e-03
GO:BP	GO:0033043	regulation of organelle organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]	28	1.006910e-02
GO:BP	GO:0061180	mammary gland epithelium development	"The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:yaf]	7	1.094935e-02
GO:BP	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	10	1.110900e-02
GO:BP	GO:0051347	positive regulation of transferase activity	"Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]	13	1.142515e-02
GO:BP	GO:0048762	mesenchymal cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid]	12	1.158760e-02
GO:BP	GO:0001837	epithelial to mesenchymal transition	"A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]	10	1.170154e-02
GO:BP	GO:0051170	import into nucleus	"The directed movement of substances into the nucleus." [GOC:ai]	10	1.170154e-02
GO:BP	GO:0033598	mammary gland epithelial cell proliferation	"The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:mah]	5	1.184233e-02
GO:BP	GO:1905314	semi-lunar valve development	"The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure." [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19409885]	6	1.185382e-02
GO:BP	GO:0140467	integrated stress response signaling	"The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041]	6	1.185382e-02
GO:BP	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	6	1.185382e-02
GO:BP	GO:0003281	ventricular septum development	"The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart]	7	1.201293e-02
GO:BP	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]	9	1.263131e-02
GO:BP	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	37	1.322362e-02
GO:BP	GO:0048546	digestive tract morphogenesis	"The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131]	6	1.340048e-02
GO:BP	GO:0035886	vascular associated smooth muscle cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954]	5	1.419821e-02
GO:BP	GO:0060487	lung epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph]	5	1.419821e-02
GO:BP	GO:0060479	lung cell differentiation	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung]	5	1.419821e-02
GO:BP	GO:0007254	JNK cascade	"A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation." [PMID:11790549, PMID:20811974, PMID:23125017]	10	1.435384e-02
GO:BP	GO:0006109	regulation of carbohydrate metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators]	10	1.435384e-02
GO:BP	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	8	1.470107e-02
GO:BP	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	15	1.491112e-02
GO:BP	GO:0045668	negative regulation of osteoblast differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]	6	1.510681e-02
GO:BP	GO:0021700	developmental maturation	"A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	14	1.555036e-02
GO:BP	GO:0042327	positive regulation of phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]	17	1.568129e-02
GO:BP	GO:0010660	regulation of muscle cell apoptotic process	"Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]	7	1.573153e-02
GO:BP	GO:0045321	leukocyte activation	"A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add]	25	1.573474e-02
GO:BP	GO:0051176	positive regulation of sulfur metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai]	3	1.595102e-02
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	27	1.662266e-02
GO:BP	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	25	1.686960e-02
GO:BP	GO:0035270	endocrine system development	"Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system]	9	1.694008e-02
GO:BP	GO:0003151	outflow tract morphogenesis	"The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]	7	1.716513e-02
GO:BP	GO:0019827	stem cell population maintenance	"The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]	10	1.838761e-02
GO:BP	GO:0010832	negative regulation of myotube differentiation	"Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]	4	1.923909e-02
GO:BP	GO:0000902	cell morphogenesis	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]	25	2.073647e-02
GO:BP	GO:0062013	positive regulation of small molecule metabolic process	"Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]	9	2.123831e-02
GO:BP	GO:0098727	maintenance of cell number	"Any process by which the numbers of cells of a particular type or in a tissue are maintained." [GOC:dos]	10	2.228556e-02
GO:BP	GO:0048514	blood vessel morphogenesis	"The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid]	19	2.362989e-02
GO:BP	GO:1901655	cellular response to ketone	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie]	8	2.367537e-02
GO:BP	GO:0010611	regulation of cardiac muscle hypertrophy	"Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb]	6	2.378214e-02
GO:BP	GO:0062197	cellular response to chemical stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712]	13	2.378498e-02
GO:BP	GO:0003188	heart valve formation	"The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]	4	2.545943e-02
GO:BP	GO:0010657	muscle cell apoptotic process	"A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb]	7	2.605997e-02
GO:BP	GO:0019216	regulation of lipid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]	13	2.627899e-02
GO:BP	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	17	2.718366e-02
GO:BP	GO:0097191	extrinsic apoptotic signaling pathway	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]	11	2.725218e-02
GO:BP	GO:2000045	regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	9	2.789144e-02
GO:BP	GO:0003300	cardiac muscle hypertrophy	"The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart]	7	2.823086e-02
GO:BP	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	19	2.936026e-02
GO:BP	GO:0071695	anatomical structure maturation	"A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah]	12	2.998174e-02
GO:BP	GO:1903707	negative regulation of hemopoiesis	"Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	8	3.061446e-02
GO:BP	GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis	"Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]	3	3.167576e-02
GO:BP	GO:0048738	cardiac muscle tissue development	"The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]	11	3.199956e-02
GO:BP	GO:0014743	regulation of muscle hypertrophy	"Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle]	6	3.262524e-02
GO:BP	GO:0043583	ear development	"The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023]	11	3.329278e-02
GO:BP	GO:0030509	BMP signaling pathway	"The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827]	9	3.442194e-02
GO:BP	GO:0060538	skeletal muscle organ development	"The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph]	10	3.528075e-02
GO:BP	GO:0014897	striated muscle hypertrophy	"The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle]	7	3.565887e-02
GO:BP	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	5	3.703786e-02
GO:BP	GO:0043276	anoikis	"Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, PMID:37667281]	5	3.703786e-02
GO:BP	GO:0030856	regulation of epithelial cell differentiation	"Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]	9	3.814749e-02
GO:BP	GO:0050832	defense response to fungus	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]	6	3.986876e-02
GO:BP	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	19	4.030837e-02
GO:BP	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	23	4.073610e-02
GO:BP	GO:0001892	embryonic placenta development	"The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]	7	4.145426e-02
GO:BP	GO:0014896	muscle hypertrophy	"The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle]	7	4.145426e-02
GO:BP	GO:0003006	developmental process involved in reproduction	"A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]	25	4.148456e-02
GO:BP	GO:0043068	positive regulation of programmed cell death	"Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	17	4.167740e-02
GO:BP	GO:0070102	interleukin-6-mediated signaling pathway	"The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling]	4	4.216501e-02
GO:BP	GO:0040008	regulation of growth	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]	18	4.251668e-02
GO:BP	GO:0001525	angiogenesis	"Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453]	17	4.265438e-02
GO:BP	GO:0009410	response to xenobiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:jl, GOC:krc]	15	4.444519e-02
GO:BP	GO:0021915	neural tube development	"The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	9	4.663537e-02
GO:BP	GO:0051154	negative regulation of striated muscle cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]	5	4.896301e-02
GO:BP	GO:1901524	regulation of mitophagy	"Any process that modulates the frequency, rate or extent of macromitophagy." [GOC:TermGenie]	5	4.896301e-02
GO:BP	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	34	4.946757e-02
GO:BP	GO:0051049	regulation of transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	33	4.951781e-02
GO:BP	GO:0042633	hair cycle	"The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, PMID:12230507]	8	4.969307e-02
GO:BP	GO:0003206	cardiac chamber morphogenesis	"The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]	8	4.969307e-02
GO:BP	GO:0008286	insulin receptor signaling pathway	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]	8	4.969307e-02
GO:BP	GO:0042303	molting cycle	"The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732]	8	4.969307e-02
GO:BP	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	10	4.993165e-02

GO:CC

source	term_id	annotation	description	intersection_size	p_value
GO:CC	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	103	6.222398e-21
GO:CC	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	36	1.375657e-18
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	111	1.740171e-16
GO:CC	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	53	2.054736e-16
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	122	1.620290e-15
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	122	1.620290e-15
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	122	1.620290e-15
GO:CC	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	109	2.338721e-15
GO:CC	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	153	1.097482e-14
GO:CC	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	59	1.449498e-13
GO:CC	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	20	1.247968e-10
GO:CC	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	181	4.068687e-10
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	195	4.161080e-10
GO:CC	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	188	4.289088e-10
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	164	7.586168e-10
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	189	2.905434e-09
GO:CC	GO:0030877	beta-catenin destruction complex	"A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]	6	1.734478e-07
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	102	1.208488e-06
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	102	1.219203e-06
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	194	1.385243e-05
GO:CC	GO:0017053	transcription repressor complex	"A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]	9	1.675110e-05
GO:CC	GO:1990909	Wnt signalosome	"A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]	5	2.624325e-05
GO:CC	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	27	7.485882e-05
GO:CC	GO:0033256	I-kappaB/NF-kappaB complex	"A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm." [GOC:bf, GOC:mah, PMID:9407099]	3	1.029414e-03
GO:CC	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	106	1.096361e-03
GO:CC	GO:0071159	NF-kappaB complex	"A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946]	3	2.555851e-03
GO:CC	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	13	3.665499e-03
GO:CC	GO:0034774	secretory granule lumen	"The volume enclosed by the membrane of a secretory granule." [GOC:rph]	13	3.665499e-03
GO:CC	GO:0060205	cytoplasmic vesicle lumen	"The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles]	13	4.314135e-03
GO:CC	GO:0031983	vesicle lumen	"The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles]	13	4.455344e-03
GO:CC	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	23	4.608220e-03
GO:CC	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	20	7.555949e-03
GO:CC	GO:0071144	heteromeric SMAD protein complex	"A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]	3	1.401997e-02
GO:CC	GO:0071141	SMAD protein complex	"A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020]	3	2.088569e-02
GO:CC	GO:0031461	cullin-RING ubiquitin ligase complex	"Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]	9	2.459302e-02
GO:CC	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	21	2.779848e-02
GO:CC	GO:1990647	C/EBP complex	"A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121]	2	2.813267e-02
GO:CC	GO:0035525	NF-kappaB p50/p65 complex	"A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584]	2	2.813267e-02
GO:CC	GO:0033257	Bcl3/NF-kappaB2 complex	"A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099]	2	2.813267e-02

GO:MF

source	term_id	annotation	description	intersection_size	p_value
GO:MF	GO:0140110	transcription regulator activity	"A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]	72	1.218132e-20
GO:MF	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	40	7.384728e-19
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	72	1.008854e-18
GO:MF	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	36	3.663047e-18
GO:MF	GO:0001216	DNA-binding transcription activator activity	"A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018]	34	2.599245e-16
GO:MF	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]	32	1.199157e-14
GO:MF	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	49	1.943456e-14
GO:MF	GO:0000987	cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018]	48	8.101513e-14
GO:MF	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	51	8.573933e-14
GO:MF	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	53	1.525059e-13
GO:MF	GO:0001067	transcription regulatory region nucleic acid binding	"Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH]	53	1.568890e-13
GO:MF	GO:0030674	protein-macromolecule adaptor activity	"An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	44	1.708566e-13
GO:MF	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	56	1.914991e-13
GO:MF	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	38	6.413428e-13
GO:MF	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	53	8.434445e-13
GO:MF	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	46	9.457472e-13
GO:MF	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	51	1.095860e-12
GO:MF	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	49	3.959761e-12
GO:MF	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	35	5.112106e-12
GO:MF	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	68	7.033409e-12
GO:MF	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	25	9.194824e-12
GO:MF	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	53	1.026072e-11
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	194	7.544051e-11
GO:MF	GO:0008013	beta-catenin binding	"Binding to a catenin beta subunit." [GOC:bf]	14	2.372094e-09
GO:MF	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	55	5.614647e-08
GO:MF	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	26	8.392388e-07
GO:MF	GO:0001221	transcription coregulator binding	"Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc]	12	1.425248e-06
GO:MF	GO:0044389	ubiquitin-like protein ligase binding	"Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]	18	3.050378e-06
GO:MF	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	22	3.169307e-06
GO:MF	GO:0070411	I-SMAD binding	"Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]	6	3.648581e-06
GO:MF	GO:0001217	DNA-binding transcription repressor activity	"A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets." [GOC:txnOH-2018]	16	1.478874e-05
GO:MF	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	16	5.044134e-05
GO:MF	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	31	2.017296e-04
GO:MF	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	56	2.652665e-04
GO:MF	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	12	3.022810e-04
GO:MF	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	10	3.417371e-04
GO:MF	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	14	3.576838e-04
GO:MF	GO:0046332	SMAD binding	"Binding to a SMAD signaling protein." [GOC:ai]	8	6.773033e-04
GO:MF	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	13	9.928864e-04
GO:MF	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	21	1.754441e-03
GO:MF	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [GOC:mah]	4	3.330193e-03
GO:MF	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	17	4.942919e-03
GO:MF	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	31	7.121146e-03
GO:MF	GO:0140767	enzyme-substrate adaptor activity	"An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity." [PMID:16250895, PMID:34358446]	7	7.643996e-03
GO:MF	GO:0043425	bHLH transcription factor binding	"Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210]	5	8.042228e-03
GO:MF	GO:0097027	ubiquitin-protein transferase activator activity	"Binds to and increases the activity of a ubiquitin-protein transferase." [GOC:rb, PMID:18321851]	4	8.276043e-03
GO:MF	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	21	9.251627e-03
GO:MF	GO:0019787	ubiquitin-like protein transferase activity	"Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686]	17	1.067213e-02
GO:MF	GO:0045309	protein phosphorylated amino acid binding	"Binding to a phosphorylated amino acid residue within a protein." [GOC:go_curators]	6	1.426321e-02
GO:MF	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	17	1.645078e-02
GO:MF	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-]	21	2.292514e-02
GO:MF	GO:0017151	DEAD/H-box RNA helicase binding	"Binding to a DEAD/H-box RNA helicase." [GOC:jl]	3	2.691810e-02
GO:MF	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	6	2.711241e-02
GO:MF	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	202	2.733057e-02
GO:MF	GO:0002039	p53 binding	"Binding to one of the p53 family of proteins." [GOC:hjd]	6	3.487827e-02
GO:MF	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	13	4.025149e-02
GO:MF	GO:0140693	molecular condensate scaffold activity	"Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate." [PMID:28225081]	5	4.382837e-02
GO:MF	GO:0002020	protease binding	"Binding to a protease or a peptidase." [GOC:hjd]	8	4.801266e-02

KEGG

source	term_id	annotation	description	intersection_size	p_value
KEGG	KEGG:05200	Pathways in cancer	Pathways in cancer	44	3.003748e-20
KEGG	KEGG:04310	Wnt signaling pathway	Wnt signaling pathway	24	4.493506e-15
KEGG	KEGG:05224	Breast cancer	Breast cancer	21	2.379901e-13
KEGG	KEGG:05226	Gastric cancer	Gastric cancer	21	2.739907e-13
KEGG	KEGG:05225	Hepatocellular carcinoma	Hepatocellular carcinoma	21	2.901817e-12
KEGG	KEGG:05165	Human papillomavirus infection	Human papillomavirus infection	27	2.320360e-11
KEGG	KEGG:04934	Cushing syndrome	Cushing syndrome	18	8.130988e-10
KEGG	KEGG:04390	Hippo signaling pathway	Hippo signaling pathway	18	1.265690e-09
KEGG	KEGG:05166	Human T-cell leukemia virus 1 infection	Human T-cell leukemia virus 1 infection	20	5.310630e-09
KEGG	KEGG:05217	Basal cell carcinoma	Basal cell carcinoma	12	9.427847e-09
KEGG	KEGG:04218	Cellular senescence	Cellular senescence	17	9.980350e-09
KEGG	KEGG:05215	Prostate cancer	Prostate cancer	14	1.211561e-08
KEGG	KEGG:04668	TNF signaling pathway	TNF signaling pathway	14	9.713538e-08
KEGG	KEGG:04919	Thyroid hormone signaling pathway	Thyroid hormone signaling pathway	14	2.424338e-07
KEGG	KEGG:05163	Human cytomegalovirus infection	Human cytomegalovirus infection	18	4.199101e-07
KEGG	KEGG:04152	AMPK signaling pathway	AMPK signaling pathway	13	2.075729e-06
KEGG	KEGG:05167	Kaposi sarcoma-associated herpesvirus infection	Kaposi sarcoma-associated herpesvirus infection	16	2.392753e-06
KEGG	KEGG:04625	C-type lectin receptor signaling pathway	C-type lectin receptor signaling pathway	12	3.638092e-06
KEGG	KEGG:04931	Insulin resistance	Insulin resistance	12	5.579701e-06
KEGG	KEGG:04380	Osteoclast differentiation	Osteoclast differentiation	13	6.560803e-06
KEGG	KEGG:04920	Adipocytokine signaling pathway	Adipocytokine signaling pathway	10	6.614433e-06
KEGG	KEGG:04658	Th1 and Th2 cell differentiation	Th1 and Th2 cell differentiation	11	6.694275e-06
KEGG	KEGG:04211	Longevity regulating pathway	Longevity regulating pathway	11	6.694275e-06
KEGG	KEGG:05222	Small cell lung cancer	Small cell lung cancer	11	9.486425e-06
KEGG	KEGG:05161	Hepatitis B	Hepatitis B	14	1.053883e-05
KEGG	KEGG:05202	Transcriptional misregulation in cancer	Transcriptional misregulation in cancer	15	1.380308e-05
KEGG	KEGG:04550	Signaling pathways regulating pluripotency of stem cells	Signaling pathways regulating pluripotency of stem cells	13	1.696429e-05
KEGG	KEGG:04916	Melanogenesis	Melanogenesis	11	2.503379e-05
KEGG	KEGG:04150	mTOR signaling pathway	mTOR signaling pathway	13	4.345618e-05
KEGG	KEGG:05210	Colorectal cancer	Colorectal cancer	10	4.823956e-05
KEGG	KEGG:04657	IL-17 signaling pathway	IL-17 signaling pathway	10	9.106904e-05
KEGG	KEGG:04151	PI3K-Akt signaling pathway	PI3K-Akt signaling pathway	19	1.118971e-04
KEGG	KEGG:01522	Endocrine resistance	Endocrine resistance	10	1.228804e-04
KEGG	KEGG:05169	Epstein-Barr virus infection	Epstein-Barr virus infection	14	1.236607e-04
KEGG	KEGG:05203	Viral carcinogenesis	Viral carcinogenesis	14	1.480212e-04
KEGG	KEGG:05220	Chronic myeloid leukemia	Chronic myeloid leukemia	9	1.565032e-04
KEGG	KEGG:05213	Endometrial cancer	Endometrial cancer	8	1.863431e-04
KEGG	KEGG:04330	Notch signaling pathway	Notch signaling pathway	8	2.425881e-04
KEGG	KEGG:05207	Chemical carcinogenesis - receptor activation	Chemical carcinogenesis - receptor activation	14	2.632690e-04
KEGG	KEGG:04659	Th17 cell differentiation	Th17 cell differentiation	10	3.092137e-04
KEGG	KEGG:05010	Alzheimer disease	Alzheimer disease	19	3.190448e-04
KEGG	KEGG:05221	Acute myeloid leukemia	Acute myeloid leukemia	8	5.665311e-04
KEGG	KEGG:04710	Circadian rhythm	Circadian rhythm	6	8.589212e-04
KEGG	KEGG:05212	Pancreatic cancer	Pancreatic cancer	8	1.463462e-03
KEGG	KEGG:04340	Hedgehog signaling pathway	Hedgehog signaling pathway	7	1.621289e-03
KEGG	KEGG:05160	Hepatitis C	Hepatitis C	11	2.059637e-03
KEGG	KEGG:04068	FoxO signaling pathway	FoxO signaling pathway	10	2.226924e-03
KEGG	KEGG:04662	B cell receptor signaling pathway	B cell receptor signaling pathway	8	2.345121e-03
KEGG	KEGG:04922	Glucagon signaling pathway	Glucagon signaling pathway	9	2.667217e-03
KEGG	KEGG:04910	Insulin signaling pathway	Insulin signaling pathway	10	3.282458e-03
KEGG	KEGG:05206	MicroRNAs in cancer	MicroRNAs in cancer	15	5.105890e-03
KEGG	KEGG:05417	Lipid and atherosclerosis	Lipid and atherosclerosis	12	7.363989e-03
KEGG	KEGG:05030	Cocaine addiction	Cocaine addiction	6	7.433214e-03
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	AGE-RAGE signaling pathway in diabetic complications	8	1.070222e-02
KEGG	KEGG:04064	NF-kappa B signaling pathway	NF-kappa B signaling pathway	8	1.230125e-02
KEGG	KEGG:04114	Oocyte meiosis	Oocyte meiosis	9	1.301077e-02
KEGG	KEGG:04210	Apoptosis	Apoptosis	9	1.635935e-02
KEGG	KEGG:05216	Thyroid cancer	Thyroid cancer	5	1.857836e-02
KEGG	KEGG:05162	Measles	Measles	9	1.931788e-02
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	Pathways of neurodegeneration - multiple diseases	18	2.057801e-02
KEGG	KEGG:04120	Ubiquitin mediated proteolysis	Ubiquitin mediated proteolysis	9	2.152758e-02
KEGG	KEGG:04936	Alcoholic liver disease	Alcoholic liver disease	9	2.394341e-02
KEGG	KEGG:05170	Human immunodeficiency virus 1 infection	Human immunodeficiency virus 1 infection	11	2.670720e-02
KEGG	KEGG:05219	Bladder cancer	Bladder cancer	5	3.044851e-02
KEGG	KEGG:05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	PD-L1 expression and PD-1 checkpoint pathway in cancer	7	3.202204e-02
KEGG	KEGG:04660	T cell receptor signaling pathway	T cell receptor signaling pathway	8	3.559210e-02
KEGG	KEGG:04932	Non-alcoholic fatty liver disease	Non-alcoholic fatty liver disease	9	4.364015e-02
KEGG	KEGG:05031	Amphetamine addiction	Amphetamine addiction	6	4.992994e-02

WP

source	term_id	annotation	description	intersection_size	p_value
WP	WP:WP5434	Cancer pathways	Cancer pathways	44	2.078586e-18
WP	WP:WP4674	Head and neck squamous cell carcinoma	Head and neck squamous cell carcinoma	17	4.958928e-13
WP	WP:WP4262	Breast cancer pathway	Breast cancer pathway	22	1.253678e-12
WP	WP:WP2064	Neural crest differentiation	Neural crest differentiation	16	1.557151e-09
WP	WP:WP710	DNA damage response only ATM dependent	DNA damage response only ATM dependent	15	5.779019e-08
WP	WP:WP1984	Integrated breast cancer pathway	Integrated breast cancer pathway	17	9.837012e-08
WP	WP:WP4754	IL18 signaling	IL18 signaling	11	3.109912e-07
WP	WP:WP4879	Overlap between signal transduction pathways contributing to LMNA laminopathies	Overlap between signal transduction pathways contributing to LMNA laminopathies	11	3.799030e-07
WP	WP:WP236	Adipogenesis	Adipogenesis	15	7.137121e-07
WP	WP:WP363	Wnt signaling NetPath	Wnt signaling NetPath	10	7.797414e-07
WP	WP:WP428	Wnt signaling	Wnt signaling	14	9.587280e-07
WP	WP:WP4258	lncRNA in canonical Wnt signaling and colorectal cancer	lncRNA in canonical Wnt signaling and colorectal cancer	13	1.322835e-06
WP	WP:WP4844	Influence of laminopathies on Wnt signaling	Influence of laminopathies on Wnt signaling	9	1.360666e-06
WP	WP:WP4331	Neovascularization processes	Neovascularization processes	9	1.360666e-06
WP	WP:WP2036	TNF related weak inducer of apoptosis TWEAK signaling	TNF related weak inducer of apoptosis TWEAK signaling	9	1.757830e-06
WP	WP:WP5087	Pleural mesothelioma	Pleural mesothelioma	26	2.171270e-06
WP	WP:WP3981	miRNA regulation of prostate cancer signaling	miRNA regulation of prostate cancer signaling	8	5.879873e-06
WP	WP:WP4211	Transcriptional cascade regulating adipogenesis	Transcriptional cascade regulating adipogenesis	6	6.314336e-06
WP	WP:WP4149	White fat cell differentiation	White fat cell differentiation	8	7.730053e-06
WP	WP:WP4482	Vitamin D in inflammatory diseases	Vitamin D in inflammatory diseases	7	8.969819e-06
WP	WP:WP3599	Transcription factor regulation in adipogenesis	Transcription factor regulation in adipogenesis	7	8.969819e-06
WP	WP:WP5124	Alzheimer 39 s disease	Alzheimer 39 s disease	19	1.139349e-05
WP	WP:WP5272	LDL influence on CD14 and TLR4	LDL influence on CD14 and TLR4	7	1.271513e-05
WP	WP:WP4787	Osteoblast differentiation and related diseases	Osteoblast differentiation and related diseases	13	1.463200e-05
WP	WP:WP2059	Alzheimer 39 s disease and miRNA effects	Alzheimer 39 s disease and miRNA effects	19	1.544484e-05
WP	WP:WP5529	Wnt Beta catenin signaling and ARTD family members	Wnt Beta catenin signaling and ARTD family members	6	1.791562e-05
WP	WP:WP399	Wnt signaling and pluripotency	Wnt signaling and pluripotency	12	1.834632e-05
WP	WP:WP2018	RANKL RANK signaling	RANKL RANK signaling	9	2.278990e-05
WP	WP:WP138	Androgen receptor signaling	Androgen receptor signaling	11	2.947030e-05
WP	WP:WP61	Notch signaling	Notch signaling	9	3.253018e-05
WP	WP:WP2840	Hair follicle development cytodifferentiation stage 3 of 3	Hair follicle development cytodifferentiation stage 3 of 3	11	3.759638e-05
WP	WP:WP5144	NRP1 triggered signaling in pancreatic cancer	NRP1 triggered signaling in pancreatic cancer	9	3.863264e-05
WP	WP:WP4336	ncRNAs in Wnt signaling in hepatocellular carcinoma	ncRNAs in Wnt signaling in hepatocellular carcinoma	11	4.235917e-05
WP	WP:WP4872	MAP3K1 role in promoting and blocking gonadal determination	MAP3K1 role in promoting and blocking gonadal determination	6	4.309534e-05
WP	WP:WP5353	Macrophage stimulating protein MSP signaling	Macrophage stimulating protein MSP signaling	12	4.345107e-05
WP	WP:WP4216	Chromosomal and microsatellite instability in colorectal cancer	Chromosomal and microsatellite instability in colorectal cancer	10	6.463156e-05
WP	WP:WP4659	Gastrin signaling	Gastrin signaling	12	7.899635e-05
WP	WP:WP4239	Epithelial to mesenchymal transition in colorectal cancer	Epithelial to mesenchymal transition in colorectal cancer	14	8.887749e-05
WP	WP:WP4658	Small cell lung cancer	Small cell lung cancer	11	9.352862e-05
WP	WP:WP5475	Hallmark of cancer sustaining proliferative signaling	Hallmark of cancer sustaining proliferative signaling	11	1.285902e-04
WP	WP:WP3414	Initiation of transcription and translation elongation at the HIV 1 LTR	Initiation of transcription and translation elongation at the HIV 1 LTR	7	1.539469e-04
WP	WP:WP2112	IL17 signaling	IL17 signaling	7	1.539469e-04
WP	WP:WP2571	Polycystic kidney disease pathway	Polycystic kidney disease pathway	10	2.456220e-04
WP	WP:WP2034	Leptin signaling	Leptin signaling	9	5.031117e-04
WP	WP:WP4746	Thyroid hormones production and peripheral downstream signaling effects	Thyroid hormones production and peripheral downstream signaling effects	10	6.324408e-04
WP	WP:WP3658	Wnt beta catenin signaling in leukemia	Wnt beta catenin signaling in leukemia	6	7.082262e-04
WP	WP:WP3931	Embryonic stem cell pluripotency pathways	Embryonic stem cell pluripotency pathways	11	7.595789e-04
WP	WP:WP5474	Catabolism of skeletal muscle in cachexia	Catabolism of skeletal muscle in cachexia	7	7.626543e-04
WP	WP:WP3664	Regulation of Wnt B catenin signaling by small molecule compounds	Regulation of Wnt B catenin signaling by small molecule compounds	5	1.323153e-03
WP	WP:WP5180	DYRK1A involvement regarding cell proliferation in brain development	DYRK1A involvement regarding cell proliferation in brain development	8	1.628658e-03
WP	WP:WP4155	Endometrial cancer	Endometrial cancer	8	1.839508e-03
WP	WP:WP45	G1 to S cell cycle control	G1 to S cell cycle control	8	2.072946e-03
WP	WP:WP1541	Energy metabolism	Energy metabolism	7	2.333566e-03
WP	WP:WP1591	Heart development	Heart development	7	2.333566e-03
WP	WP:WP4172	PI3K Akt signaling	PI3K Akt signaling	18	2.336288e-03
WP	WP:WP1403	AMP activated protein kinase signaling	AMP activated protein kinase signaling	8	2.928549e-03
WP	WP:WP5098	T cell activation SARS CoV 2	T cell activation SARS CoV 2	9	3.034611e-03
WP	WP:WP5293	Acute myeloid leukemia	Acute myeloid leukemia	8	3.272708e-03
WP	WP:WP231	TNF alpha signaling	TNF alpha signaling	9	3.328605e-03
WP	WP:WP2380	Brain derived neurotrophic factor BDNF signaling	Brain derived neurotrophic factor BDNF signaling	11	3.485849e-03
WP	WP:WP2263	Androgen receptor network in prostate cancer	Androgen receptor network in prostate cancer	10	3.658205e-03
WP	WP:WP3617	Photodynamic therapy induced NF kB survival signaling	Photodynamic therapy induced NF kB survival signaling	6	4.411973e-03
WP	WP:WP4150	Wnt signaling in kidney disease	Wnt signaling in kidney disease	6	5.222153e-03
WP	WP:WP4141	PI3K AKT mTOR vitamin D3 signaling	PI3K AKT mTOR vitamin D3 signaling	5	5.264207e-03
WP	WP:WP3594	Circadian rhythm genes	Circadian rhythm genes	13	5.762150e-03
WP	WP:WP2857	Mesodermal commitment pathway	Mesodermal commitment pathway	11	6.337627e-03
WP	WP:WP2374	Oncostatin M signaling	Oncostatin M signaling	7	7.591903e-03
WP	WP:WP3932	Focal adhesion PI3K Akt mTOR signaling	Focal adhesion PI3K Akt mTOR signaling	16	8.507830e-03
WP	WP:WP4666	Hepatitis B infection	Hepatitis B infection	11	9.204773e-03
WP	WP:WP615	Senescence and autophagy in cancer	Senescence and autophagy in cancer	9	1.255229e-02
WP	WP:WP2261	Glioblastoma signaling	Glioblastoma signaling	8	1.296372e-02
WP	WP:WP706	Sudden infant death syndrome SIDS susceptibility pathways	Sudden infant death syndrome SIDS susceptibility pathways	11	1.390229e-02
WP	WP:WP5300	TROP2 regulatory signaling	TROP2 regulatory signaling	6	1.695840e-02
WP	WP:WP268	Notch signaling	Notch signaling	6	1.695840e-02
WP	WP:WP4874	CAMKK2 pathway	CAMKK2 pathway	9	1.807353e-02
WP	WP:WP5527	NF kB signaling and ARTD family members	NF kB signaling and ARTD family members	5	1.812383e-02
WP	WP:WP4263	Pancreatic adenocarcinoma pathway	Pancreatic adenocarcinoma pathway	8	2.149233e-02
WP	WP:WP2586	Aryl hydrocarbon receptor pathway	Aryl hydrocarbon receptor pathway	6	2.189409e-02
WP	WP:WP3680	Physico chemical features and toxicity associated pathways	Physico chemical features and toxicity associated pathways	7	2.218562e-02
WP	WP:WP2355	Corticotropin releasing hormone signaling	Corticotropin releasing hormone signaling	8	2.724692e-02
WP	WP:WP5158	Urotensin II mediated signaling	Urotensin II mediated signaling	7	2.948093e-02
WP	WP:WP3858	Toll like receptor signaling related to MyD88	Toll like receptor signaling related to MyD88	5	3.009650e-02
WP	WP:WP5477	Molecular pathway for oxidative stress	Molecular pathway for oxidative stress	6	3.137005e-02
WP	WP:WP395	IL4 signaling	IL4 signaling	6	3.516308e-02
WP	WP:WP5373	Osteoarthritic chondrocyte hypertrophy	Osteoarthritic chondrocyte hypertrophy	6	3.516308e-02
WP	WP:WP3611	Photodynamic therapy induced AP 1 survival signaling	Photodynamic therapy induced AP 1 survival signaling	6	3.516308e-02
WP	WP:WP2839	Hair follicle development organogenesis stage 2 of 3	Hair follicle development organogenesis stage 2 of 3	5	3.519460e-02
WP	WP:WP5113	Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway	Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway	5	3.519460e-02
WP	WP:WP179	Cell cycle	Cell cycle	9	3.534492e-02
WP	WP:WP3286	Copper homeostasis	Copper homeostasis	6	3.930975e-02
WP	WP:WP3995	Prion disease pathway	Prion disease pathway	5	4.092678e-02
WP	WP:WP4341	Non genomic actions of 1 25 dihydroxyvitamin D3	Non genomic actions of 1 25 dihydroxyvitamin D3	7	4.587770e-02
WP	WP:WP3971	OSX and miRNAs in tooth development	OSX and miRNAs in tooth development	5	4.734412e-02
WP	WP:WP391	Mitochondrial gene expression	Mitochondrial gene expression	4	4.938077e-02

REAC

source	term_id	annotation	description	intersection_size	p_value
REAC	REAC:R-HSA-212436	Generic Transcription Pathway	Generic Transcription Pathway	48	3.950258e-08
REAC	REAC:R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	Disassembly of the destruction complex and recruitment of AXIN to the membrane	9	1.633934e-07
REAC	REAC:R-HSA-73857	RNA Polymerase II Transcription	RNA Polymerase II Transcription	48	9.716050e-07
REAC	REAC:R-HSA-74160	Gene expression (Transcription)	Gene expression (Transcription)	51	1.582842e-06
REAC	REAC:R-HSA-9843745	Adipogenesis	Adipogenesis	13	2.333721e-06
REAC	REAC:R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	Transcriptional regulation of white adipocyte differentiation	11	1.322129e-05
REAC	REAC:R-HSA-201681	TCF dependent signaling in response to WNT	TCF dependent signaling in response to WNT	17	1.899333e-05
REAC	REAC:R-HSA-195721	Signaling by WNT	Signaling by WNT	20	2.570476e-05
REAC	REAC:R-HSA-5607764	CLEC7A (Dectin-1) signaling	CLEC7A (Dectin-1) signaling	11	6.832007e-05
REAC	REAC:R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	Toll Like Receptor 3 (TLR3) Cascade	11	1.270410e-04
REAC	REAC:R-HSA-162582	Signal Transduction	Signal Transduction	66	1.508859e-04
REAC	REAC:R-HSA-166166	MyD88-independent TLR4 cascade	MyD88-independent TLR4 cascade	11	1.876776e-04
REAC	REAC:R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	TRIF (TICAM1)-mediated TLR4 signaling	11	1.876776e-04
REAC	REAC:R-HSA-5621481	C-type lectin receptors (CLRs)	C-type lectin receptors (CLRs)	12	2.942442e-04
REAC	REAC:R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	Toll Like Receptor 4 (TLR4) Cascade	12	5.045681e-04
REAC	REAC:R-HSA-8878166	Transcriptional regulation by RUNX2	Transcriptional regulation by RUNX2	11	5.047255e-04
REAC	REAC:R-HSA-9759194	Nuclear events mediated by NFE2L2	Nuclear events mediated by NFE2L2	10	5.131191e-04
REAC	REAC:R-HSA-8853884	Transcriptional Regulation by VENTX	Transcriptional Regulation by VENTX	7	5.682874e-04
REAC	REAC:R-HSA-9755511	KEAP1-NFE2L2 pathway	KEAP1-NFE2L2 pathway	11	8.272732e-04
REAC	REAC:R-HSA-9818749	Regulation of NFE2L2 gene expression	Regulation of NFE2L2 gene expression	4	1.283712e-03
REAC	REAC:R-HSA-8941326	RUNX2 regulates bone development	RUNX2 regulates bone development	6	1.725014e-03
REAC	REAC:R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	10	2.141886e-03
REAC	REAC:R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	Toll Like Receptor TLR6:TLR2 Cascade	10	2.141886e-03
REAC	REAC:R-HSA-168898	Toll-like Receptor Cascades	Toll-like Receptor Cascades	12	2.272828e-03
REAC	REAC:R-HSA-448706	Interleukin-1 processing	Interleukin-1 processing	4	2.284340e-03
REAC	REAC:R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	Toll Like Receptor 2 (TLR2) Cascade	10	2.724043e-03
REAC	REAC:R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	Toll Like Receptor TLR1:TLR2 Cascade	10	2.724043e-03
REAC	REAC:R-HSA-1280215	Cytokine Signaling in Immune system	Cytokine Signaling in Immune system	28	3.396813e-03
REAC	REAC:R-HSA-975871	MyD88 cascade initiated on plasma membrane	MyD88 cascade initiated on plasma membrane	9	4.283369e-03
REAC	REAC:R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	Toll Like Receptor 10 (TLR10) Cascade	9	4.283369e-03
REAC	REAC:R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	Toll Like Receptor 5 (TLR5) Cascade	9	4.283369e-03
REAC	REAC:R-HSA-9711123	Cellular response to chemical stress	Cellular response to chemical stress	13	5.321881e-03
REAC	REAC:R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	9	6.515779e-03
REAC	REAC:R-HSA-975155	MyD88 dependent cascade initiated on endosome	MyD88 dependent cascade initiated on endosome	9	7.064665e-03
REAC	REAC:R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	Toll Like Receptor 7/8 (TLR7/8) Cascade	9	7.652456e-03
REAC	REAC:R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	Downstream signaling events of B Cell Receptor (BCR)	8	9.100655e-03
REAC	REAC:R-HSA-5689880	Ub-specific processing proteases	Ub-specific processing proteases	13	9.172271e-03
REAC	REAC:R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	Toll Like Receptor 9 (TLR9) Cascade	9	9.672010e-03
REAC	REAC:R-HSA-1643685	Disease	Disease	48	1.072015e-02
REAC	REAC:R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	Diseases of signal transduction by growth factor receptors and second messengers	19	1.112129e-02
REAC	REAC:R-HSA-195253	Degradation of beta-catenin by the destruction complex	Degradation of beta-catenin by the destruction complex	8	1.193232e-02
REAC	REAC:R-HSA-5083630	Defective LFNG causes SCDO3	Defective LFNG causes SCDO3	3	1.308211e-02
REAC	REAC:R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	Deactivation of the beta-catenin transactivating complex	6	1.318228e-02
REAC	REAC:R-HSA-5688426	Deubiquitination	Deubiquitination	15	1.330512e-02
REAC	REAC:R-HSA-2262752	Cellular responses to stress	Cellular responses to stress	27	1.391142e-02
REAC	REAC:R-HSA-9616222	Transcriptional regulation of granulopoiesis	Transcriptional regulation of granulopoiesis	8	1.682459e-02
REAC	REAC:R-HSA-200425	Carnitine shuttle	Carnitine shuttle	4	1.713797e-02
REAC	REAC:R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	4	1.713797e-02
REAC	REAC:R-HSA-8953897	Cellular responses to stimuli	Cellular responses to stimuli	27	1.885426e-02
REAC	REAC:R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	Downregulation of SMAD2/3:SMAD4 transcriptional activity	5	2.448654e-02
REAC	REAC:R-HSA-8849470	PTK6 Regulates Cell Cycle	PTK6 Regulates Cell Cycle	3	2.588276e-02
REAC	REAC:R-HSA-1912399	Pre-NOTCH Processing in the Endoplasmic Reticulum	Pre-NOTCH Processing in the Endoplasmic Reticulum	3	2.588276e-02
REAC	REAC:R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	MAP3K8 (TPL2)-dependent MAPK1/3 activation	4	3.045547e-02
REAC	REAC:R-HSA-446652	Interleukin-1 family signaling	Interleukin-1 family signaling	10	3.155901e-02
REAC	REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	Transcriptional regulation by RUNX3	8	3.170499e-02
REAC	REAC:R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	6	3.625880e-02
REAC	REAC:R-HSA-9659787	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	4	3.937390e-02
REAC	REAC:R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	4	3.937390e-02
REAC	REAC:R-HSA-196299	Beta-catenin phosphorylation cascade	Beta-catenin phosphorylation cascade	4	3.937390e-02
REAC	REAC:R-HSA-9725371	Nuclear events stimulated by ALK signaling in cancer	Nuclear events stimulated by ALK signaling in cancer	5	4.007741e-02
REAC	REAC:R-HSA-8941855	RUNX3 regulates CDKN1A transcription	RUNX3 regulates CDKN1A transcription	3	4.480789e-02
REAC	REAC:R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	3	4.480789e-02
REAC	REAC:R-HSA-5603029	IkBA variant leads to EDA-ID	IkBA variant leads to EDA-ID	3	4.480789e-02

HP

source	term_id	annotation	description	intersection_size	p_value
HP	HP:0000006	Autosomal dominant inheritance	A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.	55	0.000982
HP	HP:0010785	Gonadal neoplasm	A tumor (abnormal growth of tissue) of a gonad.	11	0.001178
HP	HP:0010787	Genital neoplasm	A tumor (abnormal growth of tissue) of the genital system.	13	0.001554
HP	HP:0001442	Typified by somatic mosaicism	Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic.	13	0.006260
HP	HP:0100728	Germ cell neoplasia	Germ cell neoplasia	7	0.009590
HP	HP:0006753	Neoplasm of the stomach	A tumor (abnormal growth of tissue) of the stomach.	9	0.012557
HP	HP:0100526	Neoplasm of the lung	Tumor of the lung.	8	0.013007
HP	HP:0010788	Testicular neoplasm	The presence of a neoplasm of the testis.	6	0.020671
HP	HP:0100848	Neoplasm of the male external genitalia	A tumor (abnormal growth of tissue) of the male external genitalia.	6	0.024771
HP	HP:0006562	Viral hepatitis	Inflammation of the liver due to infection with a virus.	4	0.032849
HP	HP:0007379	Neoplasm of the genitourinary tract	A tumor (abnormal growth of tissue) of the genitourinary system.	14	0.033051
HP	HP:0005584	Renal cell carcinoma	A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule.	8	0.035013
HP	HP:0030448	Soft tissue sarcoma	A type of sarcoma (A connective tissue neoplasm formed by proliferation of mesodermal cells) that develops from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues.	10	0.036678

CORUM

source	term_id	annotation	description	intersection_size	p_value
CORUM	CORUM:5196	TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1)	TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1)	5	0.001058
CORUM	CORUM:6352	FoxM1-Axin-GSK3beta complex	FoxM1-Axin-GSK3beta complex	3	0.002641
CORUM	CORUM:6353	beta-Catenin destruction complex	beta-Catenin destruction complex	3	0.002641
CORUM	CORUM:6963	AXIN1-GID8-GSK3B complex	AXIN1-GID8-GSK3B complex	3	0.002641
CORUM	CORUM:6906	FBXW7-CDX2-GSK3B complex	FBXW7-CDX2-GSK3B complex	3	0.002641
CORUM	CORUM:6248	FBXW7-CSF3R-GSK3B complex	FBXW7-CSF3R-GSK3B complex	3	0.002641
CORUM	CORUM:3166	AXIN1-APC-CTNNB1-GSK3B complex	AXIN1-APC-CTNNB1-GSK3B complex	3	0.002641
CORUM	CORUM:2086	NFKB1-NFKB2-RELA-RELB complex	NFKB1-NFKB2-RELA-RELB complex	3	0.002641
CORUM	CORUM:2706	SMAD3-SMAD4-SP1 complex	SMAD3-SMAD4-SP1 complex	3	0.002641
CORUM	CORUM:2084	NFKB1-NFKB2-REL-RELA-RELB complex	NFKB1-NFKB2-REL-RELA-RELB complex	3	0.010373
CORUM	CORUM:2998	Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex	Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex	3	0.010373
CORUM	CORUM:7159	TSC2-GSK3-AXIN-DVL complex	TSC2-GSK3-AXIN-DVL complex	3	0.010373
CORUM	CORUM:4151	TSC (TSC1, TSC2, AXIN, GSK3) complex	TSC (TSC1, TSC2, AXIN, GSK3) complex	3	0.010373
CORUM	CORUM:2189	Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1)	Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1)	3	0.025462

TF

source	term_id	annotation	description	intersection_size	p_value
TF	TF:M12703_1	Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1	Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1	77	0.002389
TF	TF:M09734	Factor: ZNF692; motif: SYNGGSCCCASCCNC	Factor: ZNF692; motif: SYNGGSCCCASCCNC	156	0.003978
TF	TF:M12722_1	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1	103	0.005748
TF	TF:M01100	Factor: LRF; motif: GGGGKYNNB	Factor: LRF; motif: GGGGKYNNB	113	0.005841
TF	TF:M00695_1	Factor: ETF; motif: GVGGMGG; match class: 1	Factor: ETF; motif: GVGGMGG; match class: 1	107	0.006698
TF	TF:M01219	Factor: SP1:SP3; motif: CCSCCCCCYCC	Factor: SP1:SP3; motif: CCSCCCCCYCC	104	0.010087
TF	TF:M01972	Factor: EGR-1; motif: TGCGTGGGCGK	Factor: EGR-1; motif: TGCGTGGGCGK	87	0.012077
TF	TF:M04953	Factor: Sp1; motif: GGNDGGRGGCGGGG	Factor: Sp1; motif: GGNDGGRGGCGGGG	124	0.013183
TF	TF:M10112	Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR	Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR	124	0.014393
TF	TF:M09834	Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN	Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN	105	0.014713
TF	TF:M00245_1	Factor: Egr-3; motif: NTGCGTGGGCGK; match class: 1	Factor: Egr-3; motif: NTGCGTGGGCGK; match class: 1	48	0.018274
TF	TF:M01104_1	Factor: MOVO-B; motif: GNGGGGG; match class: 1	Factor: MOVO-B; motif: GNGGGGG; match class: 1	89	0.032774
TF	TF:M10108	Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG	Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG	99	0.035356
TF	TF:M01972_1	Factor: EGR-1; motif: TGCGTGGGCGK; match class: 1	Factor: EGR-1; motif: TGCGTGGGCGK; match class: 1	34	0.047623
TF	TF:M00695	Factor: ETF; motif: GVGGMGG	Factor: ETF; motif: GVGGMGG	140	0.048855

MIRNA

source	term_id	annotation	description	intersection_size	p_value
MIRNA	MIRNA:hsa-mir-4765	hsa-mir-4765	hsa-mir-4765	22	0.007803
MIRNA	MIRNA:hsa-mir-670	hsa-mir-670	hsa-mir-670	31	0.008868
MIRNA	MIRNA:hsa-mir-200b-3p	hsa-mir-200b-3p	hsa-mir-200b-3p	10	0.024354
MIRNA	MIRNA:hsa-mir-7-5p	hsa-mir-7-5p	hsa-mir-7-5p	19	0.028338
MIRNA	MIRNA:hsa-mir-34a-3p	hsa-mir-34a-3p	hsa-mir-34a-3p	7	0.043726

Community 1

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	89	5.530402e-38	1
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	48	1.028087e-24	1
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	158	1.042181e-24	1
GO:CC	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	57	8.306907e-24	1
GO:CC	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917]	72	1.714415e-23	1
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	71	3.872132e-23	1
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	106	8.026464e-23	1
GO:CC	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	43	2.046078e-20	1
GO:CC	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	39	2.106946e-19	1
GO:CC	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	65	2.279486e-19	1
GO:CC	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	33	2.871582e-18	1
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	30	9.771412e-18	1
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	29	5.914139e-17	1
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	107	1.135867e-16	1
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	107	1.149842e-16	1
GO:CC	GO:0099080	supramolecular complex	"A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]	47	2.015552e-15	1
GO:CC	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	24	1.900297e-14	1
GO:CC	GO:0099513	polymeric cytoskeletal fiber	"A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos]	35	2.250954e-14	1
GO:CC	GO:0099512	supramolecular fiber	"A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos]	38	3.070538e-13	1
GO:CC	GO:0099081	supramolecular polymer	"A polymeric supramolecular structure." [GOC:dos]	38	3.904619e-13	1
GO:CC	GO:0031252	cell leading edge	"The area of a motile cell closest to the direction of movement." [GOC:pg]	25	1.032019e-12	1
GO:CC	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	26	1.076768e-11	1
GO:CC	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	25	1.882817e-11	1
GO:CC	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	15	5.504957e-10	1
GO:CC	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	22	8.519401e-10	1
GO:CC	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	26	1.843494e-09	1
GO:CC	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	28	2.373647e-09	1
GO:CC	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060]	36	1.053473e-08	1
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	40	1.478360e-08	1
GO:CC	GO:0005912	adherens junction	"A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]	14	6.233976e-08	1
GO:CC	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	14	1.707824e-07	1
GO:CC	GO:0002102	podosome	"An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982]	8	2.167906e-07	1
GO:CC	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	13	2.534119e-07	1
GO:CC	GO:0098978	glutamatergic synapse	"A synapse that uses glutamate as a neurotransmitter." [GOC:dos]	22	3.737478e-07	1
GO:CC	GO:0034451	centriolar satellite	"A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812]	11	1.300709e-06	1
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	162	3.020026e-06	1
GO:CC	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	12	5.662224e-06	1
GO:CC	GO:0030863	cortical cytoskeleton	"The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah]	10	7.097144e-06	1
GO:CC	GO:0043296	apical junction complex	"A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556]	11	8.912411e-06	1
GO:CC	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	20	2.522242e-05	1
GO:CC	GO:0097447	dendritic tree	"The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168]	20	2.653912e-05	1
GO:CC	GO:0098984	neuron to neuron synapse	"A synapse in which pre and post-synaptic cells are neurons." [GOC:dos]	16	3.161976e-05	1
GO:CC	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	11	4.125897e-05	1
GO:CC	GO:0001726	ruffle	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]	11	5.153853e-05	1
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	155	5.230322e-05	1
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	150	1.054562e-04	1
GO:CC	GO:0099572	postsynaptic specialization	"A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028]	15	1.137117e-04	1
GO:CC	GO:0005915	zonula adherens	"A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208]	4	1.156217e-04	1
GO:CC	GO:0005875	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	10	1.187610e-04	1
GO:CC	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	9	1.279401e-04	1
GO:CC	GO:0042641	actomyosin	"Any complex of actin, myosin, and accessory proteins." [GOC:go_curators]	8	1.650726e-04	1
GO:CC	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	11	1.758209e-04	1
GO:CC	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	21	1.949343e-04	1
GO:CC	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	10	1.972946e-04	1
GO:CC	GO:0036477	somatodendritic compartment	"The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL]	22	2.007451e-04	1
GO:CC	GO:0030427	site of polarized growth	"Any part of a cell where non-isotropic growth takes place." [GOC:mah]	10	2.581036e-04	1
GO:CC	GO:0098590	plasma membrane region	"A membrane that is a (regional) part of the plasma membrane." [GOC:dos]	28	2.827523e-04	1
GO:CC	GO:0032279	asymmetric synapse	"A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef]	14	3.235763e-04	1
GO:CC	GO:0044291	cell-cell contact zone	"Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018]	7	5.395746e-04	1
GO:CC	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	106	6.672930e-04	1
GO:CC	GO:0014704	intercalated disc	"A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910]	6	8.901258e-04	1
GO:CC	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density]	13	1.102973e-03	1
GO:CC	GO:0030864	cortical actin cytoskeleton	"The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]	7	1.150127e-03	1
GO:CC	GO:0097517	contractile actin filament bundle	"An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194]	7	1.244063e-03	1
GO:CC	GO:0001725	stress fiber	"A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381]	7	1.244063e-03	1
GO:CC	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	19	1.303599e-03	1
GO:CC	GO:0016328	lateral plasma membrane	"The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr]	7	1.451179e-03	1
GO:CC	GO:1990752	microtubule end	"Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end." [GOC:pr]	5	2.192880e-03	1
GO:CC	GO:0032432	actin filament bundle	"An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah]	7	2.415537e-03	1
GO:CC	GO:0150034	distal axon	"That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468]	11	3.201048e-03	1
GO:CC	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	7	3.618554e-03	1
GO:CC	GO:0030056	hemidesmosome	"A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195]	3	4.316307e-03	1
GO:CC	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	74	5.340320e-03	1
GO:CC	GO:0000242	pericentriolar material	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]	4	6.211682e-03	1
GO:CC	GO:0036464	cytoplasmic ribonucleoprotein granule	"A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]	10	8.812876e-03	1
GO:CC	GO:0099091	postsynaptic specialization, intracellular component	"A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos]	4	8.916461e-03	1
GO:CC	GO:0120103	centriolar subdistal appendage	"A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68." [GOC:cilia, PMID:23213374, PMID:27818179, PMID:28422092]	3	1.455100e-02	1
GO:CC	GO:0035770	ribonucleoprotein granule	"A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]	10	1.604331e-02	1
GO:CC	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	8	1.634203e-02	1
GO:CC	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	68	1.889818e-02	1
GO:CC	GO:0043197	dendritic spine	"A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]	8	2.076970e-02	1
GO:CC	GO:0044309	neuron spine	"A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck." [ISBN:0198504888, NIF_Subcellular:sao1145756102]	8	2.424232e-02	1
GO:CC	GO:0016342	catenin complex	"Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323]	4	2.532597e-02	1
GO:CC	GO:0000779	condensed chromosome, centromeric region	"The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]	8	2.615140e-02	1
GO:CC	GO:0032587	ruffle membrane	"The portion of the plasma membrane surrounding a ruffle." [GOC:mah]	6	3.634133e-02	1
GO:CC	GO:1904115	axon cytoplasm	"Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152]	5	3.733348e-02	1
GO:CC	GO:0098685	Schaffer collateral - CA1 synapse	"A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell." [PMID:16399689]	6	4.270085e-02	1

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	72	2.940390e-34	1
GO:BP	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	89	6.943126e-23	1
GO:BP	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	43	8.983688e-17	1
GO:BP	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	36	1.350071e-16	1
GO:BP	GO:0030030	cell projection organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917]	53	4.609953e-16	1
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	69	5.161519e-16	1
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	69	6.544606e-16	1
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	79	1.769165e-15	1
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc]	51	4.488714e-15	1
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	72	2.789509e-14	1
GO:BP	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	61	1.234345e-13	1
GO:BP	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	21	5.226294e-13	1
GO:BP	GO:0097435	supramolecular fiber organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr]	35	2.711039e-12	1
GO:BP	GO:0034330	cell junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]	34	6.762048e-12	1
GO:BP	GO:0051493	regulation of cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]	26	1.456568e-10	1
GO:BP	GO:0000902	cell morphogenesis	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]	34	1.103850e-09	1
GO:BP	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	29	1.724137e-09	1
GO:BP	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	34	1.773690e-09	1
GO:BP	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	88	1.808556e-09	1
GO:BP	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	32	2.466184e-09	1
GO:BP	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	111	2.758954e-09	1
GO:BP	GO:0030010	establishment of cell polarity	"The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	15	5.368313e-09	1
GO:BP	GO:0030029	actin filament-based process	"Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]	30	6.453946e-09	1
GO:BP	GO:0032886	regulation of microtubule-based process	"Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah]	18	9.720196e-09	1
GO:BP	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	33	1.181176e-08	1
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	47	1.791025e-08	1
GO:BP	GO:0071840	cellular component organization or biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]	111	1.815892e-08	1
GO:BP	GO:0070925	organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	33	2.139962e-08	1
GO:BP	GO:0048666	neuron development	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]	35	2.387369e-08	1
GO:BP	GO:0072698	protein localization to microtubule cytoskeleton	"A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah]	10	5.752418e-08	1
GO:BP	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	139	7.238976e-08	1
GO:BP	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	53	1.097181e-07	1
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	37	1.132194e-07	1
GO:BP	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	38	1.144423e-07	1
GO:BP	GO:0044380	protein localization to cytoskeleton	"A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl]	10	1.153070e-07	1
GO:BP	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	69	1.367033e-07	1
GO:BP	GO:0048699	generation of neurons	"The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]	39	1.514998e-07	1
GO:BP	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	141	1.641250e-07	1
GO:BP	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	31	2.017960e-07	1
GO:BP	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	42	2.019996e-07	1
GO:BP	GO:0034329	cell junction assembly	"A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah]	22	2.072229e-07	1
GO:BP	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	21	2.700013e-07	1
GO:BP	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	42	2.965185e-07	1
GO:BP	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	135	3.478282e-07	1
GO:BP	GO:1902903	regulation of supramolecular fiber organization	"Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]	19	5.172923e-07	1
GO:BP	GO:0031023	microtubule organizing center organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah]	13	5.925779e-07	1
GO:BP	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	8	8.338145e-07	1
GO:BP	GO:0051656	establishment of organelle localization	"The directed movement of an organelle to a specific location." [GOC:ai]	21	8.505442e-07	1
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	"The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb]	23	9.740171e-07	1
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	"Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	23	1.005970e-06	1
GO:BP	GO:1905508	protein localization to microtubule organizing center	"A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497]	8	1.048983e-06	1
GO:BP	GO:0033043	regulation of organelle organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]	32	1.062993e-06	1
GO:BP	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	55	1.120790e-06	1
GO:BP	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	86	1.188766e-06	1
GO:BP	GO:0030031	cell projection assembly	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:18391171]	23	1.521359e-06	1
GO:BP	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	52	1.581030e-06	1
GO:BP	GO:0051640	organelle localization	"Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]	23	1.892410e-06	1
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	"The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc]	24	1.899635e-06	1
GO:BP	GO:0034453	microtubule anchoring	"Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]	7	1.975950e-06	1
GO:BP	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	37	2.139954e-06	1
GO:BP	GO:0048858	cell projection morphogenesis	"The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021]	24	2.198146e-06	1
GO:BP	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	12	2.624413e-06	1
GO:BP	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	90	3.324730e-06	1
GO:BP	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	23	6.224431e-06	1
GO:BP	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	72	6.629623e-06	1
GO:BP	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	72	7.156327e-06	1
GO:BP	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	59	8.268280e-06	1
GO:BP	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	33	9.413456e-06	1
GO:BP	GO:0007044	cell-substrate junction assembly	"The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah]	10	9.569353e-06	1
GO:BP	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	42	1.238221e-05	1
GO:BP	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	12	1.596127e-05	1
GO:BP	GO:0150115	cell-substrate junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	10	1.907122e-05	1
GO:BP	GO:0140694	membraneless organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081]	18	2.241639e-05	1
GO:BP	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	58	2.475248e-05	1
GO:BP	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	35	2.565262e-05	1
GO:BP	GO:0044085	cellular component biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]	73	2.880668e-05	1
GO:BP	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	22	2.959248e-05	1
GO:BP	GO:0045216	cell-cell junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	13	3.749739e-05	1
GO:BP	GO:0033365	protein localization to organelle	"A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]	30	5.625645e-05	1
GO:BP	GO:0023057	negative regulation of signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	33	6.371890e-05	1
GO:BP	GO:0010648	negative regulation of cell communication	"Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	33	6.478420e-05	1
GO:BP	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	50	9.688915e-05	1
GO:BP	GO:0071896	protein localization to adherens junction	"Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237]	4	1.065493e-04	1
GO:BP	GO:0072393	microtubule anchoring at microtubule organizing center	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938]	5	1.065919e-04	1
GO:BP	GO:0032271	regulation of protein polymerization	"Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]	12	1.374421e-04	1
GO:BP	GO:0051258	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	14	1.375582e-04	1
GO:BP	GO:0031344	regulation of cell projection organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]	21	1.414969e-04	1
GO:BP	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	51	2.009920e-04	1
GO:BP	GO:0030705	cytoskeleton-dependent intracellular transport	"The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]	12	2.348303e-04	1
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	38	3.156405e-04	1
GO:BP	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	17	3.267038e-04	1
GO:BP	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	7	3.371665e-04	1
GO:BP	GO:0031589	cell-substrate adhesion	"The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf]	15	3.586837e-04	1
GO:BP	GO:0010970	transport along microtubule	"The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb]	11	3.804614e-04	1
GO:BP	GO:0007409	axonogenesis	"De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]	17	3.808252e-04	1
GO:BP	GO:0110053	regulation of actin filament organization	"Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv]	13	3.955316e-04	1
GO:BP	GO:0099111	microtubule-based transport	"A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	12	4.093879e-04	1
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc]	20	4.344825e-04	1
GO:BP	GO:0061564	axon development	"The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr]	18	4.910310e-04	1
GO:BP	GO:1990778	protein localization to cell periphery	"A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290]	15	4.937726e-04	1
GO:BP	GO:0007049	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]	34	6.302740e-04	1
GO:BP	GO:0035088	establishment or maintenance of apical/basal cell polarity	"Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]	7	6.442147e-04	1
GO:BP	GO:0061245	establishment or maintenance of bipolar cell polarity	"Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns." [GOC:dph, GOC:vw]	7	6.442147e-04	1
GO:BP	GO:0030865	cortical cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	7	6.442147e-04	1
GO:BP	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	29	6.731320e-04	1
GO:BP	GO:0048041	focal adhesion assembly	"The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah]	8	7.493370e-04	1
GO:BP	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	12	9.091691e-04	1
GO:BP	GO:0007043	cell-cell junction assembly	"The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]	10	9.833250e-04	1
GO:BP	GO:0060560	developmental growth involved in morphogenesis	"The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph]	12	1.039322e-03	1
GO:BP	GO:1903829	positive regulation of protein localization	"Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	17	1.083451e-03	1
GO:BP	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	90	1.146435e-03	1
GO:BP	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	13	1.250089e-03	1
GO:BP	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	83	1.281730e-03	1
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	25	1.648069e-03	1
GO:BP	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441]	15	1.723717e-03	1
GO:BP	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	63	1.772479e-03	1
GO:BP	GO:0048869	cellular developmental process	"A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]	63	1.786895e-03	1
GO:BP	GO:0032535	regulation of cellular component size	"A process that modulates the size of a cellular component." [GOC:mah]	14	2.111950e-03	1
GO:BP	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	11	2.166626e-03	1
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	13	2.276448e-03	1
GO:BP	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	33	2.367613e-03	1
GO:BP	GO:0031503	protein-containing complex localization	"A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]	11	2.486260e-03	1
GO:BP	GO:0030859	polarized epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:mah]	5	2.633324e-03	1
GO:BP	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	16	2.968557e-03	1
GO:BP	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	76	3.839021e-03	1
GO:BP	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	15	3.956528e-03	1
GO:BP	GO:0032970	regulation of actin filament-based process	"Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah]	14	4.007641e-03	1
GO:BP	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	81	4.996333e-03	1
GO:BP	GO:0043297	apical junction assembly	"The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556]	7	5.120864e-03	1
GO:BP	GO:0030111	regulation of Wnt signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]	13	5.227231e-03	1
GO:BP	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	17	5.585429e-03	1
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	13	5.769450e-03	1
GO:BP	GO:0010975	regulation of neuron projection development	"Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	15	6.007192e-03	1
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	34	7.389567e-03	1
GO:BP	GO:0016358	dendrite development	"The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]	11	7.808719e-03	1
GO:BP	GO:0051960	regulation of nervous system development	"Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]	15	8.068596e-03	1
GO:BP	GO:0051494	negative regulation of cytoskeleton organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]	9	8.319938e-03	1
GO:BP	GO:1902904	negative regulation of supramolecular fiber organization	"Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]	9	9.238949e-03	1
GO:BP	GO:0034332	adherens junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah]	6	1.138573e-02	1
GO:BP	GO:0001952	regulation of cell-matrix adhesion	"Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]	8	1.165754e-02	1
GO:BP	GO:0031346	positive regulation of cell projection organization	"Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]	13	1.187576e-02	1
GO:BP	GO:0007051	spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah]	10	1.208679e-02	1
GO:BP	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	6	1.261550e-02	1
GO:BP	GO:0051234	establishment of localization	"Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]	65	1.496953e-02	1
GO:BP	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	12	1.521250e-02	1
GO:BP	GO:0030833	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	8	1.661789e-02	1
GO:BP	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA	"Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544]	3	1.789825e-02	1
GO:BP	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	77	1.799857e-02	1
GO:BP	GO:0010810	regulation of cell-substrate adhesion	"Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb]	10	1.907065e-02	1
GO:BP	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	18	1.960422e-02	1
GO:BP	GO:0090109	regulation of cell-substrate junction assembly	"Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb]	6	2.048681e-02	1
GO:BP	GO:0051893	regulation of focal adhesion assembly	"Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai]	6	2.048681e-02	1
GO:BP	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	13	2.185905e-02	1
GO:BP	GO:0090066	regulation of anatomical structure size	"Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb]	15	2.354645e-02	1
GO:BP	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	15	2.646150e-02	1
GO:BP	GO:0031109	microtubule polymerization or depolymerization	"Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]	8	2.881358e-02	1
GO:BP	GO:0035735	intraciliary transport involved in cilium assembly	"The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia]	3	3.113664e-02	1
GO:BP	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	"A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544]	3	3.113664e-02	1
GO:BP	GO:0150116	regulation of cell-substrate junction organization	"Any process that modulates the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk]	6	3.192642e-02	1
GO:BP	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	43	3.421913e-02	1
GO:BP	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	25	3.465516e-02	1
GO:BP	GO:0050770	regulation of axonogenesis	"Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]	8	4.333276e-02	1
GO:BP	GO:0032272	negative regulation of protein polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]	6	4.438152e-02	1
GO:BP	GO:0008154	actin polymerization or depolymerization	"Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]	9	4.458694e-02	1
GO:BP	GO:0008064	regulation of actin polymerization or depolymerization	"Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]	8	4.551689e-02	1
GO:BP	GO:0048589	developmental growth	"The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]	17	4.669926e-02	1
GO:BP	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	4	4.698923e-02	1
GO:BP	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	23	4.832606e-02	1

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	55	7.928756e-27	1
GO:MF	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	28	8.676221e-14	1
GO:MF	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	30	7.322626e-13	1
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	168	2.991812e-12	1
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	23	1.025807e-11	1
GO:MF	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	17	2.399025e-07	1
GO:MF	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	15	2.592555e-07	1
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	46	1.181746e-06	1
GO:MF	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	18	5.723139e-06	1
GO:MF	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	25	1.438322e-05	1
GO:MF	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	32	5.216788e-05	1
GO:MF	GO:0008013	beta-catenin binding	"Binding to a catenin beta subunit." [GOC:bf]	9	2.649898e-04	1
GO:MF	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	20	6.480201e-04	1
GO:MF	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	21	6.643858e-04	1
GO:MF	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	28	1.087066e-03	1
GO:MF	GO:0017166	vinculin binding	"Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544]	4	1.670449e-03	1
GO:MF	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	4	2.396690e-03	1
GO:MF	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	172	1.460662e-02	1
GO:MF	GO:0048156	tau protein binding	"Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]	5	2.209983e-02	1
GO:MF	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	19	3.284473e-02	1
GO:MF	GO:0008093	cytoskeletal anchor activity	"The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238]	4	3.308117e-02	1
GO:MF	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	7	3.940769e-02	1

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	35	3.559979e-13	1
REAC	REAC:R-HSA-194315	Signaling by Rho GTPases	Signaling by Rho GTPases	33	8.966724e-12	1
REAC	REAC:R-HSA-162582	Signal Transduction	Signal Transduction	62	2.747814e-11	1
REAC	REAC:R-HSA-380259	Loss of Nlp from mitotic centrosomes	Loss of Nlp from mitotic centrosomes	11	2.641123e-08	1
REAC	REAC:R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	Loss of proteins required for interphase microtubule organization from the centrosome	11	2.641123e-08	1
REAC	REAC:R-HSA-8854518	AURKA Activation by TPX2	AURKA Activation by TPX2	11	4.302766e-08	1
REAC	REAC:R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	Recruitment of mitotic centrosome proteins and complexes	11	1.633920e-07	1
REAC	REAC:R-HSA-380287	Centrosome maturation	Centrosome maturation	11	1.633920e-07	1
REAC	REAC:R-HSA-9012999	RHO GTPase cycle	RHO GTPase cycle	22	2.069399e-07	1
REAC	REAC:R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	Regulation of PLK1 Activity at G2/M Transition	11	3.191778e-07	1
REAC	REAC:R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	Recruitment of NuMA to mitotic centrosomes	11	9.585022e-07	1
REAC	REAC:R-HSA-111465	Apoptotic cleavage of cellular proteins	Apoptotic cleavage of cellular proteins	8	1.083113e-06	1
REAC	REAC:R-HSA-5620912	Anchoring of the basal body to the plasma membrane	Anchoring of the basal body to the plasma membrane	11	1.204137e-06	1
REAC	REAC:R-HSA-109581	Apoptosis	Apoptosis	13	9.162830e-06	1
REAC	REAC:R-HSA-1500931	Cell-Cell communication	Cell-Cell communication	12	1.368723e-05	1
REAC	REAC:R-HSA-75153	Apoptotic execution phase	Apoptotic execution phase	8	1.591030e-05	1
REAC	REAC:R-HSA-5357801	Programmed Cell Death	Programmed Cell Death	13	6.622558e-05	1
REAC	REAC:R-HSA-446728	Cell junction organization	Cell junction organization	10	8.717253e-05	1
REAC	REAC:R-HSA-69275	G2/M Transition	G2/M Transition	12	2.578643e-04	1
REAC	REAC:R-HSA-453274	Mitotic G2-G2/M phases	Mitotic G2-G2/M phases	12	2.874893e-04	1
REAC	REAC:R-HSA-68877	Mitotic Prometaphase	Mitotic Prometaphase	12	3.201022e-04	1
REAC	REAC:R-HSA-199991	Membrane Trafficking	Membrane Trafficking	21	3.649455e-04	1
REAC	REAC:R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	COPI-independent Golgi-to-ER retrograde traffic	7	4.021625e-04	1
REAC	REAC:R-HSA-9013424	RHOV GTPase cycle	RHOV GTPase cycle	6	7.276558e-04	1
REAC	REAC:R-HSA-9696264	RND3 GTPase cycle	RND3 GTPase cycle	6	1.576659e-03	1
REAC	REAC:R-HSA-5617833	Cilium Assembly	Cilium Assembly	11	2.230683e-03	1
REAC	REAC:R-HSA-5653656	Vesicle-mediated transport	Vesicle-mediated transport	21	3.375941e-03	1
REAC	REAC:R-HSA-114452	Activation of BH3-only proteins	Activation of BH3-only proteins	5	4.924894e-03	1
REAC	REAC:R-HSA-195258	RHO GTPase Effectors	RHO GTPase Effectors	13	7.575663e-03	1
REAC	REAC:R-HSA-9013404	RAC2 GTPase cycle	RAC2 GTPase cycle	7	1.243113e-02	1
REAC	REAC:R-HSA-2028269	Signaling by Hippo	Signaling by Hippo	4	1.511003e-02	1
REAC	REAC:R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	Diseases of signal transduction by growth factor receptors and second messengers	15	1.554846e-02	1
REAC	REAC:R-HSA-9013420	RHOU GTPase cycle	RHOU GTPase cycle	5	1.852370e-02	1
REAC	REAC:R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	Signaling by Receptor Tyrosine Kinases	16	2.349749e-02	1
REAC	REAC:R-HSA-8856688	Golgi-to-ER retrograde transport	Golgi-to-ER retrograde transport	8	2.487066e-02	1
REAC	REAC:R-HSA-9696273	RND1 GTPase cycle	RND1 GTPase cycle	5	2.672394e-02	1
REAC	REAC:R-HSA-9696270	RND2 GTPase cycle	RND2 GTPase cycle	5	3.000109e-02	1

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M02036	Factor: WT1; motif: CGCCCCCNCN	Factor: WT1; motif: CGCCCCCNCN	138	2.305626e-11	1
TF	TF:M00695_1	Factor: ETF; motif: GVGGMGG; match class: 1	Factor: ETF; motif: GVGGMGG; match class: 1	112	2.477433e-10	1
TF	TF:M07208	Factor: EGR1; motif: NCNCCGCCCCCGCN	Factor: EGR1; motif: NCNCCGCCCCCGCN	102	2.179115e-09	1
TF	TF:M01873	Factor: Egr-1; motif: GCGGGGGCGG	Factor: Egr-1; motif: GCGGGGGCGG	107	2.771469e-09	1
TF	TF:M13127_1	Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1	Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1	120	3.687219e-08	1
TF	TF:M07354	Factor: Egr-1; motif: GCGGGGGCGG	Factor: Egr-1; motif: GCGGGGGCGG	114	2.292663e-07	1
TF	TF:M02089_1	Factor: E2F-3; motif: GGCGGGN; match class: 1	Factor: E2F-3; motif: GGCGGGN; match class: 1	127	2.411051e-07	1
TF	TF:M00695	Factor: ETF; motif: GVGGMGG	Factor: ETF; motif: GVGGMGG	135	4.156253e-07	1
TF	TF:M10108	Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG	Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG	100	5.776961e-07	1
TF	TF:M03893	Factor: WT1; motif: GNGGGGGCGGGG	Factor: WT1; motif: GNGGGGGCGGGG	116	9.580296e-07	1
TF	TF:M00982	Factor: KROX; motif: CCCGCCCCCRCCCC	Factor: KROX; motif: CCCGCCCCCRCCCC	111	2.181715e-06	1
TF	TF:M02036_1	Factor: WT1; motif: CGCCCCCNCN; match class: 1	Factor: WT1; motif: CGCCCCCNCN; match class: 1	86	2.742169e-06	1
TF	TF:M01219_1	Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1	Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1	59	3.002434e-06	1
TF	TF:M07329	Factor: Osx; motif: CCNCCCCCNNN	Factor: Osx; motif: CCNCCCCCNNN	101	3.586267e-06	1
TF	TF:M01219	Factor: SP1:SP3; motif: CCSCCCCCYCC	Factor: SP1:SP3; motif: CCSCCCCCYCC	100	7.081455e-06	1
TF	TF:M09636_1	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1	159	8.564566e-06	1
TF	TF:M13144_1	Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS; match class: 1	Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS; match class: 1	85	8.836223e-06	1
TF	TF:M12722_1	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1	98	1.038020e-05	1
TF	TF:M08878	Factor: EGR; motif: CGCCCCCGCNN	Factor: EGR; motif: CGCCCCCGCNN	106	1.194013e-05	1
TF	TF:M12703_1	Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1	Factor: ZNF383; motif: SSNGGGMGGNGSNGGS; match class: 1	74	1.270724e-05	1
TF	TF:M09826	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC	141	1.518770e-05	1
TF	TF:M11529_1	Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1	Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1	161	1.623129e-05	1
TF	TF:M00196	Factor: Sp1; motif: NGGGGGCGGGGYN	Factor: Sp1; motif: NGGGGGCGGGGYN	130	1.676250e-05	1
TF	TF:M13366	Factor: ZBED4; motif: CCCGCYCCGC	Factor: ZBED4; motif: CCCGCYCCGC	107	2.129465e-05	1
TF	TF:M09826_1	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1	107	2.271086e-05	1
TF	TF:M02089	Factor: E2F-3; motif: GGCGGGN	Factor: E2F-3; motif: GGCGGGN	152	2.337288e-05	1
TF	TF:M01104_1	Factor: MOVO-B; motif: GNGGGGG; match class: 1	Factor: MOVO-B; motif: GNGGGGG; match class: 1	87	2.826504e-05	1
TF	TF:M08878_1	Factor: EGR; motif: CGCCCCCGCNN; match class: 1	Factor: EGR; motif: CGCCCCCGCNN; match class: 1	60	2.975118e-05	1
TF	TF:M01104	Factor: MOVO-B; motif: GNGGGGG	Factor: MOVO-B; motif: GNGGGGG	129	4.179511e-05	1
TF	TF:M00986_1	Factor: Churchill; motif: CGGGNN; match class: 1	Factor: Churchill; motif: CGGGNN; match class: 1	130	4.730344e-05	1
TF	TF:M11531	Factor: E2F-2; motif: GCGCGCGCGYW	Factor: E2F-2; motif: GCGCGCGCGYW	152	4.811747e-05	1
TF	TF:M10072	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR	131	5.167236e-05	1
TF	TF:M09761	Factor: EGR1; motif: NGNGKGGGYGGNGS	Factor: EGR1; motif: NGNGKGGGYGGNGS	81	6.046444e-05	1
TF	TF:M10026	Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN	Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN	111	7.156506e-05	1
TF	TF:M07289_1	Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1	Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1	131	7.567338e-05	1
TF	TF:M13366_1	Factor: ZBED4; motif: CCCGCYCCGC; match class: 1	Factor: ZBED4; motif: CCCGCYCCGC; match class: 1	66	8.575155e-05	1
TF	TF:M12703	Factor: ZNF383; motif: SSNGGGMGGNGSNGGS	Factor: ZNF383; motif: SSNGGGMGGNGSNGGS	118	9.579206e-05	1
TF	TF:M07354_1	Factor: Egr-1; motif: GCGGGGGCGG; match class: 1	Factor: Egr-1; motif: GCGGGGGCGG; match class: 1	64	9.640036e-05	1
TF	TF:M07615	Factor: Sp3; motif: GGGGCGGGGSNN	Factor: Sp3; motif: GGGGCGGGGSNN	97	1.038289e-04	1
TF	TF:M13124	Factor: ZNF670; motif: SNGGGCRGRG	Factor: ZNF670; motif: SNGGGCRGRG	147	1.516389e-04	1
TF	TF:M01199_1	Factor: RNF96; motif: BCCCGCRGCC; match class: 1	Factor: RNF96; motif: BCCCGCRGCC; match class: 1	71	1.564952e-04	1
TF	TF:M03567	Factor: Sp2; motif: NYSGCCCCGCCCCCY	Factor: Sp2; motif: NYSGCCCCGCCCCCY	105	1.620928e-04	1
TF	TF:M00803_1	Factor: E2F; motif: GGCGSG; match class: 1	Factor: E2F; motif: GGCGSG; match class: 1	127	1.882561e-04	1
TF	TF:M07039_1	Factor: ETF; motif: CCCCGCCCCYN; match class: 1	Factor: ETF; motif: CCCCGCCCCYN; match class: 1	153	2.172065e-04	1
TF	TF:M07226_1	Factor: SP1; motif: NCCCCKCCCCC; match class: 1	Factor: SP1; motif: NCCCCKCCCCC; match class: 1	66	2.386844e-04	1
TF	TF:M09984	Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG	Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG	121	2.628909e-04	1
TF	TF:M03807	Factor: SP2; motif: GNNGGGGGCGGGGSN	Factor: SP2; motif: GNNGGGGGCGGGGSN	111	2.731798e-04	1
TF	TF:M00931_1	Factor: Sp1; motif: GGGGCGGGGC; match class: 1	Factor: Sp1; motif: GGGGCGGGGC; match class: 1	87	3.036247e-04	1
TF	TF:M08867_1	Factor: AP2; motif: GCCYGSGGSN; match class: 1	Factor: AP2; motif: GCCYGSGGSN; match class: 1	79	3.076148e-04	1
TF	TF:M04953	Factor: Sp1; motif: GGNDGGRGGCGGGG	Factor: Sp1; motif: GGNDGGRGGCGGGG	113	3.211170e-04	1
TF	TF:M07395	Factor: Sp1; motif: NGGGGCGGGGN	Factor: Sp1; motif: NGGGGCGGGGN	130	3.338728e-04	1
TF	TF:M00931	Factor: Sp1; motif: GGGGCGGGGC	Factor: Sp1; motif: GGGGCGGGGC	127	3.378910e-04	1
TF	TF:M00982_1	Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1	Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1	61	3.630706e-04	1
TF	TF:M10072_1	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1	Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1	90	3.887856e-04	1
TF	TF:M00933_1	Factor: Sp1; motif: CCCCGCCCCN; match class: 1	Factor: Sp1; motif: CCCCGCCCCN; match class: 1	79	4.245512e-04	1
TF	TF:M07277	Factor: BTEB2; motif: RGGGNGKGGN	Factor: BTEB2; motif: RGGGNGKGGN	111	4.425593e-04	1
TF	TF:M07395_1	Factor: Sp1; motif: NGGGGCGGGGN; match class: 1	Factor: Sp1; motif: NGGGGCGGGGN; match class: 1	91	4.507349e-04	1
TF	TF:M13147_1	Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN; match class: 1	Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN; match class: 1	93	5.148467e-04	1
TF	TF:M07277_1	Factor: BTEB2; motif: RGGGNGKGGN; match class: 1	Factor: BTEB2; motif: RGGGNGKGGN; match class: 1	68	5.153761e-04	1
TF	TF:M13129_1	Factor: RERE; motif: CNGCNSCNNGSRCRGSGSS; match class: 1	Factor: RERE; motif: CNGCNSCNNGSRCRGSGSS; match class: 1	85	5.157578e-04	1
TF	TF:M00803	Factor: E2F; motif: GGCGSG	Factor: E2F; motif: GGCGSG	149	5.577901e-04	1
TF	TF:M09723	Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS	Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS	124	5.884358e-04	1
TF	TF:M12351_1	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1	107	5.932535e-04	1
TF	TF:M09973_1	Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1	Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1	93	7.133542e-04	1
TF	TF:M10435	Factor: Sp2; motif: GGGGCGGGG	Factor: Sp2; motif: GGGGCGGGG	103	7.661026e-04	1
TF	TF:M00933	Factor: Sp1; motif: CCCCGCCCCN	Factor: Sp1; motif: CCCCGCCCCN	121	7.897623e-04	1
TF	TF:M00932	Factor: Sp1; motif: NNGGGGCGGGGNN	Factor: Sp1; motif: NNGGGGCGGGGNN	127	9.014363e-04	1
TF	TF:M12227	Factor: ZIC4; motif: NNCCNCCCRYNGYGN	Factor: ZIC4; motif: NNCCNCCCRYNGYGN	132	9.496663e-04	1
TF	TF:M00932_1	Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1	Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1	87	9.674137e-04	1
TF	TF:M01199	Factor: RNF96; motif: BCCCGCRGCC	Factor: RNF96; motif: BCCCGCRGCC	110	9.930966e-04	1
TF	TF:M10432	Factor: MAZ; motif: GGGMGGGGS	Factor: MAZ; motif: GGGMGGGGS	117	1.093032e-03	1
TF	TF:M12648	Factor: PATZ1; motif: SCNCCNCNSCCCCCASCCN	Factor: PATZ1; motif: SCNCCNCNSCCCCCASCCN	69	1.233177e-03	1
TF	TF:M10112	Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR	Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR	111	1.739546e-03	1
TF	TF:M01303	Factor: SP1; motif: GGGGYGGGGNS	Factor: SP1; motif: GGGGYGGGGNS	104	1.887451e-03	1
TF	TF:M07063	Factor: Sp1; motif: GGGGCGGGGC	Factor: Sp1; motif: GGGGCGGGGC	88	1.985779e-03	1
TF	TF:M01873_1	Factor: Egr-1; motif: GCGGGGGCGG; match class: 1	Factor: Egr-1; motif: GCGGGGGCGG; match class: 1	49	2.128961e-03	1
TF	TF:M02090_1	Factor: E2F-4; motif: GCGGGAAANA; match class: 1	Factor: E2F-4; motif: GCGGGAAANA; match class: 1	89	2.227700e-03	1
TF	TF:M07329_1	Factor: Osx; motif: CCNCCCCCNNN; match class: 1	Factor: Osx; motif: CCNCCCCCNNN; match class: 1	47	2.377963e-03	1
TF	TF:M08441_1	Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1	Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1	144	2.382335e-03	1
TF	TF:M10071_1	Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1	Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1	71	2.414578e-03	1
TF	TF:M10112_1	Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR; match class: 1	Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR; match class: 1	65	2.428511e-03	1
TF	TF:M10026_1	Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN; match class: 1	Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN; match class: 1	73	2.508676e-03	1
TF	TF:M01303_1	Factor: SP1; motif: GGGGYGGGGNS; match class: 1	Factor: SP1; motif: GGGGYGGGGNS; match class: 1	59	2.525730e-03	1
TF	TF:M07436	Factor: WT1; motif: NNGGGNGGGSGN	Factor: WT1; motif: NNGGGNGGGSGN	90	2.634530e-03	1
TF	TF:M11531_1	Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1	Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1	141	2.673813e-03	1
TF	TF:M13128	Factor: MED8; motif: CYYNSCYYCCTSCNCC	Factor: MED8; motif: CYYNSCYYCCTSCNCC	144	2.864452e-03	1
TF	TF:M10432_1	Factor: MAZ; motif: GGGMGGGGS; match class: 1	Factor: MAZ; motif: GGGMGGGGS; match class: 1	68	3.240730e-03	1
TF	TF:M03807_1	Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1	Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1	66	3.447301e-03	1
TF	TF:M10086_1	Factor: TAFII250; motif: RARRWGGCGGMGGNGR; match class: 1	Factor: TAFII250; motif: RARRWGGCGGMGGNGR; match class: 1	63	3.896149e-03	1
TF	TF:M02281	Factor: SP1; motif: CCCCKCCCCC	Factor: SP1; motif: CCCCKCCCCC	89	4.110789e-03	1
TF	TF:M00986	Factor: Churchill; motif: CGGGNN	Factor: Churchill; motif: CGGGNN	154	4.425159e-03	1
TF	TF:M12722	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS	Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS	126	4.595754e-03	1
TF	TF:M11601	Factor: TCF-1; motif: ACATCGRGRCGCTGW	Factor: TCF-1; motif: ACATCGRGRCGCTGW	158	4.601695e-03	1
TF	TF:M09636	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG	Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG	167	4.703490e-03	1
TF	TF:M12158	Factor: KLF15; motif: NCCMCGCCCMCN	Factor: KLF15; motif: NCCMCGCCCMCN	125	5.001002e-03	1
TF	TF:M10530_1	Factor: sp4; motif: NNNGCYCCGCCCCCY; match class: 1	Factor: sp4; motif: NNNGCYCCGCCCCCY; match class: 1	61	5.025304e-03	1
TF	TF:M09898	Factor: Egr-2; motif: GNGRRNGWGKGGGNGGRG	Factor: Egr-2; motif: GNGRRNGWGKGGGNGGRG	89	5.045879e-03	1
TF	TF:M13124_1	Factor: ZNF670; motif: SNGGGCRGRG; match class: 1	Factor: ZNF670; motif: SNGGGCRGRG; match class: 1	105	5.151648e-03	1
TF	TF:M03893_1	Factor: WT1; motif: GNGGGGGCGGGG; match class: 1	Factor: WT1; motif: GNGGGGGCGGGG; match class: 1	63	5.449350e-03	1
TF	TF:M11601_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	130	5.514774e-03	1
TF	TF:M03896	Factor: EGR1; motif: NACGCCCACGCANW	Factor: EGR1; motif: NACGCCCACGCANW	85	5.562403e-03	1
TF	TF:M10530	Factor: sp4; motif: NNNGCYCCGCCCCCY	Factor: sp4; motif: NNNGCYCCGCCCCCY	105	5.646646e-03	1
TF	TF:M09603	Factor: Egr-1; motif: NNNNNGYGKGGGNGGGNN	Factor: Egr-1; motif: NNNNNGYGKGGGNGGGNN	70	5.977554e-03	1
TF	TF:M08526	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN	170	6.340781e-03	1
TF	TF:M08867	Factor: AP2; motif: GCCYGSGGSN	Factor: AP2; motif: GCCYGSGGSN	121	6.351317e-03	1
TF	TF:M09894_1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	152	6.494961e-03	1
TF	TF:M11603	Factor: TCF-1; motif: ACATCGRGRCGCTGW	Factor: TCF-1; motif: ACATCGRGRCGCTGW	167	6.546185e-03	1
TF	TF:M08526_1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	159	7.035975e-03	1
TF	TF:M00196_1	Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1	Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1	83	7.707292e-03	1
TF	TF:M09859	Factor: NF90; motif: NCCNCWGCCYCCNC	Factor: NF90; motif: NCCNCWGCCYCCNC	70	8.125275e-03	1
TF	TF:M12508_1	Factor: EGR1; motif: NNMCGCCCACGCNN; match class: 1	Factor: EGR1; motif: NNMCGCCCACGCNN; match class: 1	42	8.783702e-03	1
TF	TF:M09765_1	Factor: SP1; motif: NRGKGGGCGGGGCN; match class: 1	Factor: SP1; motif: NRGKGGGCGGGGCN; match class: 1	55	9.110788e-03	1
TF	TF:M02281_1	Factor: SP1; motif: CCCCKCCCCC; match class: 1	Factor: SP1; motif: CCCCKCCCCC; match class: 1	46	9.365704e-03	1
TF	TF:M01858	Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN	Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN	97	9.721218e-03	1
TF	TF:M07040_1	Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1	Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1	104	9.730110e-03	1
TF	TF:M09984_1	Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1	Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1	79	1.036489e-02	1
TF	TF:M00333_1	Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1	Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1	140	1.066844e-02	1
TF	TF:M10435_1	Factor: Sp2; motif: GGGGCGGGG; match class: 1	Factor: Sp2; motif: GGGGCGGGG; match class: 1	57	1.143741e-02	1
TF	TF:M09723_1	Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1	Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1	83	1.200938e-02	1
TF	TF:M12227_1	Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1	Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1	82	1.202891e-02	1
TF	TF:M07039	Factor: ETF; motif: CCCCGCCCCYN	Factor: ETF; motif: CCCCGCCCCYN	167	1.203868e-02	1
TF	TF:M12160	Factor: KLF15; motif: RCCMCRCCCMCN	Factor: KLF15; motif: RCCMCRCCCMCN	142	1.270236e-02	1
TF	TF:M07208_1	Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1	Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1	41	1.276219e-02	1
TF	TF:M10108_1	Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG; match class: 1	Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG; match class: 1	49	1.402272e-02	1
TF	TF:M12313	Factor: ZNF460; motif: NNACNCCCCCCNN	Factor: ZNF460; motif: NNACNCCCCCCNN	81	1.545427e-02	1
TF	TF:M09892	Factor: E2F-1; motif: NNNNGGCGGGAARN	Factor: E2F-1; motif: NNNNGGCGGGAARN	148	1.547964e-02	1
TF	TF:M13127	Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS	Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS	138	1.549474e-02	1
TF	TF:M12742	Factor: ZNF93; motif: GGYAGCRGCAGCGGYG	Factor: ZNF93; motif: GGYAGCRGCAGCGGYG	45	1.552824e-02	1
TF	TF:M00244	Factor: NGFI-C; motif: WTGCGTGGGYGG	Factor: NGFI-C; motif: WTGCGTGGGYGG	84	1.650350e-02	1
TF	TF:M09970	Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN	Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN	99	1.710111e-02	1
TF	TF:M11018_1	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1	164	1.782698e-02	1
TF	TF:M00716_1	Factor: ZF5; motif: GSGCGCGR; match class: 1	Factor: ZF5; motif: GSGCGCGR; match class: 1	152	1.837578e-02	1
TF	TF:M11603_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	145	1.839581e-02	1
TF	TF:M07397_1	Factor: ZBP89; motif: CCCCKCCCCCNN; match class: 1	Factor: ZBP89; motif: CCCCKCCCCCNN; match class: 1	50	1.851672e-02	1
TF	TF:M07226	Factor: SP1; motif: NCCCCKCCCCC	Factor: SP1; motif: NCCCCKCCCCC	104	1.884152e-02	1
TF	TF:M09658	Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS	Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS	75	1.981690e-02	1
TF	TF:M09738	Factor: ZNF511; motif: GGRRGRGGCWGNG	Factor: ZNF511; motif: GGRRGRGGCWGNG	126	2.214066e-02	1
TF	TF:M10438_1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	157	2.383574e-02	1
TF	TF:M12597	Factor: E2F1; motif: GSGCGGGAAN	Factor: E2F1; motif: GSGCGGGAAN	151	2.422748e-02	1
TF	TF:M09765	Factor: SP1; motif: NRGKGGGCGGGGCN	Factor: SP1; motif: NRGKGGGCGGGGCN	96	2.745002e-02	1
TF	TF:M12183	Factor: KLF14; motif: NRCCACRCCCMCN	Factor: KLF14; motif: NRCCACRCCCMCN	90	2.864741e-02	1
TF	TF:M12599_1	Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1	Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1	162	3.080579e-02	1
TF	TF:M04826_1	Factor: p300; motif: ACNTCCG; match class: 1	Factor: p300; motif: ACNTCCG; match class: 1	159	3.133687e-02	1
TF	TF:M07289	Factor: GKLF; motif: NNNRGGNGNGGSN	Factor: GKLF; motif: NNNRGGNGNGGSN	155	3.259534e-02	1
TF	TF:M00008_1	Factor: Sp1; motif: GGGGCGGGGT; match class: 1	Factor: Sp1; motif: GGGGCGGGGT; match class: 1	71	3.292012e-02	1
TF	TF:M00915	Factor: AP-2; motif: SNNNCCNCAGGCN	Factor: AP-2; motif: SNNNCCNCAGGCN	115	3.371217e-02	1
TF	TF:M12351	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC	137	3.487075e-02	1
TF	TF:M13135	Factor: SP4; motif: GGCCCCGCCCCCN	Factor: SP4; motif: GGCCCCGCCCCCN	77	3.893827e-02	1
TF	TF:M00427	Factor: E2F; motif: TTTSGCGS	Factor: E2F; motif: TTTSGCGS	114	4.021491e-02	1
TF	TF:M09897_1	Factor: Egr-1; motif: NNNNGCGKGGGYGGNRN; match class: 1	Factor: Egr-1; motif: NNNNGCGKGGGYGGNRN; match class: 1	24	4.158867e-02	1
TF	TF:M13144	Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS	Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS	113	4.182604e-02	1
TF	TF:M09970_1	Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1	Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1	58	4.385485e-02	1
TF	TF:M09894	Factor: E2F-4; motif: SNGGGCGGGAANN	Factor: E2F-4; motif: SNGGGCGGGAANN	165	4.486027e-02	1
TF	TF:M07063_1	Factor: Sp1; motif: GGGGCGGGGC; match class: 1	Factor: Sp1; motif: GGGGCGGGGC; match class: 1	44	4.534607e-02	1
TF	TF:M12590_1	Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1	Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1	88	4.769082e-02	1

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0320000	Nasopharynx	Nasopharynx	125	1.320928e-09	1
HPA	HPA:0210000	Fallopian tube	Fallopian tube	126	1.096350e-08	1
HPA	HPA:0050000	Breast	Breast	123	2.331181e-08	1
HPA	HPA:0130000	Colon	Colon	132	4.952591e-08	1
HPA	HPA:0050051	Breast; glandular cells[≥Low]	Breast; glandular cells[≥Low]	118	1.818773e-07	1
HPA	HPA:0170000	Endometrium 2	Endometrium 2	119	1.910836e-07	1
HPA	HPA:0180000	Epididymis	Epididymis	122	6.956656e-07	1
HPA	HPA:0180051	Epididymis; glandular cells[≥Low]	Epididymis; glandular cells[≥Low]	122	6.956656e-07	1
HPA	HPA:0610000	Urinary bladder	Urinary bladder	121	1.671709e-06	1
HPA	HPA:0610831	Urinary bladder; urothelial cells[≥Low]	Urinary bladder; urothelial cells[≥Low]	121	1.671709e-06	1
HPA	HPA:0400000	Rectum	Rectum	127	1.755131e-06	1
HPA	HPA:0130201	Colon; endothelial cells[≥Low]	Colon; endothelial cells[≥Low]	104	1.771414e-06	1
HPA	HPA:0130052	Colon; glandular cells[≥Medium]	Colon; glandular cells[≥Medium]	107	2.934665e-06	1
HPA	HPA:0460000	Skin 1	Skin 1	120	2.957868e-06	1
HPA	HPA:0550051	Stomach 2; glandular cells[≥Low]	Stomach 2; glandular cells[≥Low]	123	5.108852e-06	1
HPA	HPA:0550000	Stomach 2	Stomach 2	123	5.108852e-06	1
HPA	HPA:0350000	Pancreas	Pancreas	121	5.963886e-06	1
HPA	HPA:0380000	Placenta	Placenta	122	6.174623e-06	1
HPA	HPA:0340000	Ovary	Ovary	100	6.353173e-06	1
HPA	HPA:0220051	Gallbladder; glandular cells[≥Low]	Gallbladder; glandular cells[≥Low]	123	9.409658e-06	1
HPA	HPA:0220000	Gallbladder	Gallbladder	123	9.409658e-06	1
HPA	HPA:0050091	Breast; myoepithelial cells[≥Low]	Breast; myoepithelial cells[≥Low]	102	1.178058e-05	1
HPA	HPA:0420000	Salivary gland	Salivary gland	115	1.998154e-05	1
HPA	HPA:0420051	Salivary gland; glandular cells[≥Low]	Salivary gland; glandular cells[≥Low]	115	1.998154e-05	1
HPA	HPA:0130202	Colon; endothelial cells[≥Medium]	Colon; endothelial cells[≥Medium]	77	2.004925e-05	1
HPA	HPA:0030000	Appendix	Appendix	124	2.022210e-05	1
HPA	HPA:0630221	Cervix; squamous epithelial cells[≥Low]	Cervix; squamous epithelial cells[≥Low]	99	2.148363e-05	1
HPA	HPA:0170051	Endometrium 2; glandular cells[≥Low]	Endometrium 2; glandular cells[≥Low]	113	2.418170e-05	1
HPA	HPA:0590051	Thyroid gland; glandular cells[≥Low]	Thyroid gland; glandular cells[≥Low]	117	2.685041e-05	1
HPA	HPA:0590000	Thyroid gland	Thyroid gland	117	2.685041e-05	1
HPA	HPA:0480000	Small intestine	Small intestine	124	3.416580e-05	1
HPA	HPA:0540051	Stomach 1; glandular cells[≥Low]	Stomach 1; glandular cells[≥Low]	122	3.453276e-05	1
HPA	HPA:0540000	Stomach 1	Stomach 1	122	3.453276e-05	1
HPA	HPA:0190000	Esophagus	Esophagus	112	4.184268e-05	1
HPA	HPA:0190221	Esophagus; squamous epithelial cells[≥Low]	Esophagus; squamous epithelial cells[≥Low]	112	4.184268e-05	1
HPA	HPA:0600000	Tonsil	Tonsil	123	4.339316e-05	1
HPA	HPA:0351181	Pancreas; pancreatic endocrine cells[≥Low]	Pancreas; pancreatic endocrine cells[≥Low]	100	5.480038e-05	1
HPA	HPA:0130051	Colon; glandular cells[≥Low]	Colon; glandular cells[≥Low]	115	5.803199e-05	1
HPA	HPA:0020051	Adrenal gland; glandular cells[≥Low]	Adrenal gland; glandular cells[≥Low]	119	6.940450e-05	1
HPA	HPA:0020000	Adrenal gland	Adrenal gland	119	7.500919e-05	1
HPA	HPA:0430000	Seminal vesicle	Seminal vesicle	113	7.514559e-05	1
HPA	HPA:0430051	Seminal vesicle; glandular cells[≥Low]	Seminal vesicle; glandular cells[≥Low]	113	7.514559e-05	1
HPA	HPA:0030051	Appendix; glandular cells[≥Low]	Appendix; glandular cells[≥Low]	112	9.221555e-05	1
HPA	HPA:0320101	Nasopharynx; respiratory epithelial cells[≥Low]	Nasopharynx; respiratory epithelial cells[≥Low]	101	1.024995e-04	1
HPA	HPA:0590052	Thyroid gland; glandular cells[≥Medium]	Thyroid gland; glandular cells[≥Medium]	99	1.074196e-04	1
HPA	HPA:0160000	Endometrium 1	Endometrium 1	115	1.118454e-04	1
HPA	HPA:0180052	Epididymis; glandular cells[≥Medium]	Epididymis; glandular cells[≥Medium]	100	1.129491e-04	1
HPA	HPA:0500651	Soft tissue 1; fibroblasts[≥Low]	Soft tissue 1; fibroblasts[≥Low]	82	1.198881e-04	1
HPA	HPA:0100000	Cerebral cortex	Cerebral cortex	125	1.280546e-04	1
HPA	HPA:0150000	Duodenum	Duodenum	123	1.497294e-04	1
HPA	HPA:0270000	Kidney	Kidney	126	1.536645e-04	1
HPA	HPA:0600221	Tonsil; squamous epithelial cells[≥Low]	Tonsil; squamous epithelial cells[≥Low]	110	2.304264e-04	1
HPA	HPA:0610832	Urinary bladder; urothelial cells[≥Medium]	Urinary bladder; urothelial cells[≥Medium]	102	3.066802e-04	1
HPA	HPA:0400051	Rectum; glandular cells[≥Low]	Rectum; glandular cells[≥Low]	114	3.358896e-04	1
HPA	HPA:0220052	Gallbladder; glandular cells[≥Medium]	Gallbladder; glandular cells[≥Medium]	109	4.125684e-04	1
HPA	HPA:0330000	Oral mucosa	Oral mucosa	105	4.400098e-04	1
HPA	HPA:0330221	Oral mucosa; squamous epithelial cells[≥Low]	Oral mucosa; squamous epithelial cells[≥Low]	105	4.400098e-04	1
HPA	HPA:0210051	Fallopian tube; glandular cells[≥Low]	Fallopian tube; glandular cells[≥Low]	99	4.898417e-04	1
HPA	HPA:0160051	Endometrium 1; glandular cells[≥Low]	Endometrium 1; glandular cells[≥Low]	111	5.060460e-04	1
HPA	HPA:0150051	Duodenum; glandular cells[≥Low]	Duodenum; glandular cells[≥Low]	114	5.238269e-04	1
HPA	HPA:0630000	Cervix	Cervix	112	5.678905e-04	1
HPA	HPA:0470000	Skin 2	Skin 2	113	6.580859e-04	1
HPA	HPA:0350471	Pancreas; exocrine glandular cells[≥Low]	Pancreas; exocrine glandular cells[≥Low]	112	6.816548e-04	1
HPA	HPA:0500000	Soft tissue 1	Soft tissue 1	94	7.588235e-04	1
HPA	HPA:0480052	Small intestine; glandular cells[≥Medium]	Small intestine; glandular cells[≥Medium]	102	9.457290e-04	1
HPA	HPA:0480051	Small intestine; glandular cells[≥Low]	Small intestine; glandular cells[≥Low]	113	1.034894e-03	1
HPA	HPA:0300000	Lung	Lung	116	1.084070e-03	1
HPA	HPA:0620221	Vagina; squamous epithelial cells[≥Low]	Vagina; squamous epithelial cells[≥Low]	101	1.150244e-03	1
HPA	HPA:0620000	Vagina	Vagina	101	1.150244e-03	1
HPA	HPA:0340461	Ovary; ovarian stroma cells[≥Low]	Ovary; ovarian stroma cells[≥Low]	76	1.175764e-03	1
HPA	HPA:0270351	Kidney; cells in glomeruli[≥Low]	Kidney; cells in glomeruli[≥Low]	91	1.257342e-03	1
HPA	HPA:0550052	Stomach 2; glandular cells[≥Medium]	Stomach 2; glandular cells[≥Medium]	104	1.368438e-03	1
HPA	HPA:0050052	Breast; glandular cells[≥Medium]	Breast; glandular cells[≥Medium]	90	1.507193e-03	1
HPA	HPA:0290000	Liver	Liver	104	1.552913e-03	1
HPA	HPA:0100201	Cerebral cortex; endothelial cells[≥Low]	Cerebral cortex; endothelial cells[≥Low]	84	1.618821e-03	1
HPA	HPA:0420052	Salivary gland; glandular cells[≥Medium]	Salivary gland; glandular cells[≥Medium]	87	1.649337e-03	1
HPA	HPA:0510000	Soft tissue 2	Soft tissue 2	91	1.795133e-03	1
HPA	HPA:0390052	Prostate; glandular cells[≥Medium]	Prostate; glandular cells[≥Medium]	86	1.905597e-03	1
HPA	HPA:0170052	Endometrium 2; glandular cells[≥Medium]	Endometrium 2; glandular cells[≥Medium]	87	1.933417e-03	1
HPA	HPA:0060000	Bronchus	Bronchus	116	2.027224e-03	1
HPA	HPA:0360000	Parathyroid gland	Parathyroid gland	99	2.162477e-03	1
HPA	HPA:0360051	Parathyroid gland; glandular cells[≥Low]	Parathyroid gland; glandular cells[≥Low]	99	2.162477e-03	1
HPA	HPA:0320102	Nasopharynx; respiratory epithelial cells[≥Medium]	Nasopharynx; respiratory epithelial cells[≥Medium]	85	2.280794e-03	1
HPA	HPA:0400052	Rectum; glandular cells[≥Medium]	Rectum; glandular cells[≥Medium]	101	3.128222e-03	1
HPA	HPA:0090000	Cerebellum	Cerebellum	113	3.240313e-03	1
HPA	HPA:0600222	Tonsil; squamous epithelial cells[≥Medium]	Tonsil; squamous epithelial cells[≥Medium]	87	3.306779e-03	1
HPA	HPA:0160052	Endometrium 1; glandular cells[≥Medium]	Endometrium 1; glandular cells[≥Medium]	89	5.266242e-03	1
HPA	HPA:0030052	Appendix; glandular cells[≥Medium]	Appendix; glandular cells[≥Medium]	93	6.257912e-03	1
HPA	HPA:0150052	Duodenum; glandular cells[≥Medium]	Duodenum; glandular cells[≥Medium]	100	6.938555e-03	1
HPA	HPA:0130241	Colon; peripheral nerve/ganglion[≥Low]	Colon; peripheral nerve/ganglion[≥Low]	87	7.925752e-03	1
HPA	HPA:0291161	Liver; cholangiocytes[≥Low]	Liver; cholangiocytes[≥Low]	73	9.168380e-03	1
HPA	HPA:0210052	Fallopian tube; glandular cells[≥Medium]	Fallopian tube; glandular cells[≥Medium]	82	1.117534e-02	1
HPA	HPA:0540052	Stomach 1; glandular cells[≥Medium]	Stomach 1; glandular cells[≥Medium]	102	1.303117e-02	1
HPA	HPA:0490691	Smooth muscle; smooth muscle cells[≥Low]	Smooth muscle; smooth muscle cells[≥Low]	91	1.713382e-02	1
HPA	HPA:0490000	Smooth muscle	Smooth muscle	91	1.713382e-02	1
HPA	HPA:0460671	Skin 1; melanocytes[≥Low]	Skin 1; melanocytes[≥Low]	89	1.941066e-02	1
HPA	HPA:0510651	Soft tissue 2; fibroblasts[≥Low]	Soft tissue 2; fibroblasts[≥Low]	74	2.069376e-02	1
HPA	HPA:0390000	Prostate	Prostate	105	2.177996e-02	1
HPA	HPA:0390051	Prostate; glandular cells[≥Low]	Prostate; glandular cells[≥Low]	105	2.177996e-02	1
HPA	HPA:0460661	Skin 1; keratinocytes[≥Low]	Skin 1; keratinocytes[≥Low]	87	2.245551e-02	1
HPA	HPA:0291162	Liver; cholangiocytes[≥Medium]	Liver; cholangiocytes[≥Medium]	43	2.486778e-02	1
HPA	HPA:0310000	Lymph node	Lymph node	103	2.861143e-02	1
HPA	HPA:0380521	Placenta; trophoblastic cells[≥Low]	Placenta; trophoblastic cells[≥Low]	101	2.961100e-02	1
HPA	HPA:0380522	Placenta; trophoblastic cells[≥Medium]	Placenta; trophoblastic cells[≥Medium]	85	3.543391e-02	1
HPA	HPA:0600441	Tonsil; non-germinal center cells[≥Low]	Tonsil; non-germinal center cells[≥Low]	98	3.630816e-02	1
HPA	HPA:0300201	Lung; endothelial cells[≥Low]	Lung; endothelial cells[≥Low]	23	3.778363e-02	1
HPA	HPA:0060102	Bronchus; respiratory epithelial cells[≥Medium]	Bronchus; respiratory epithelial cells[≥Medium]	83	4.342836e-02	1
HPA	HPA:0310441	Lymph node; non-germinal center cells[≥Low]	Lymph node; non-germinal center cells[≥Low]	97	4.419116e-02	1
HPA	HPA:0100211	Cerebral cortex; neuropil[≥Low]	Cerebral cortex; neuropil[≥Low]	84	4.739545e-02	1

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-548ah	hsa-mir-548ah	hsa-mir-548ah	47	1.910113e-09	1
MIRNA	MIRNA:hsa-mir-141	hsa-mir-141	hsa-mir-141	46	5.287586e-09	1
MIRNA	MIRNA:hsa-mir-200a	hsa-mir-200a	hsa-mir-200a	46	5.287586e-09	1
MIRNA	MIRNA:hsa-mir-3609	hsa-mir-3609	hsa-mir-3609	48	5.430332e-09	1
MIRNA	MIRNA:hsa-mir-582-5p	hsa-mir-582-5p	hsa-mir-582-5p	43	4.778882e-08	1
MIRNA	MIRNA:hsa-mir-410	hsa-mir-410	hsa-mir-410	37	2.193219e-07	1
MIRNA	MIRNA:hsa-mir-4796-3p	hsa-mir-4796-3p	hsa-mir-4796-3p	40	1.901399e-06	1
MIRNA	MIRNA:hsa-mir-548aa	hsa-mir-548aa	hsa-mir-548aa	44	3.416119e-06	1
MIRNA	MIRNA:hsa-mir-340	hsa-mir-340	hsa-mir-340	42	4.870064e-06	1
MIRNA	MIRNA:hsa-mir-139-5p	hsa-mir-139-5p	hsa-mir-139-5p	32	7.530118e-06	1
MIRNA	MIRNA:hsa-mir-106b-5p	hsa-mir-106b-5p	hsa-mir-106b-5p	32	1.548346e-05	1
MIRNA	MIRNA:hsa-mir-4801	hsa-mir-4801	hsa-mir-4801	39	1.595558e-05	1
MIRNA	MIRNA:hsa-mir-4731-3p	hsa-mir-4731-3p	hsa-mir-4731-3p	39	1.625740e-05	1
MIRNA	MIRNA:hsa-mir-503	hsa-mir-503	hsa-mir-503	28	2.235333e-05	1
MIRNA	MIRNA:hsa-mir-548z	hsa-mir-548z	hsa-mir-548z	45	2.344327e-05	1
MIRNA	MIRNA:hsa-mir-548ac	hsa-mir-548ac	hsa-mir-548ac	45	2.344327e-05	1
MIRNA	MIRNA:hsa-mir-548d-3p	hsa-mir-548d-3p	hsa-mir-548d-3p	45	2.541109e-05	1
MIRNA	MIRNA:hsa-mir-577	hsa-mir-577	hsa-mir-577	32	2.592686e-05	1
MIRNA	MIRNA:hsa-mir-664	hsa-mir-664	hsa-mir-664	36	2.687904e-05	1
MIRNA	MIRNA:hsa-mir-4666-3p	hsa-mir-4666-3p	hsa-mir-4666-3p	39	3.574824e-05	1
MIRNA	MIRNA:hsa-mir-3942-3p	hsa-mir-3942-3p	hsa-mir-3942-3p	39	3.909166e-05	1
MIRNA	MIRNA:hsa-mir-548c-3p	hsa-mir-548c-3p	hsa-mir-548c-3p	63	4.371473e-05	1
MIRNA	MIRNA:hsa-mir-4276	hsa-mir-4276	hsa-mir-4276	34	4.692635e-05	1
MIRNA	MIRNA:hsa-mir-93-5p	hsa-mir-93-5p	hsa-mir-93-5p	33	5.279311e-05	1
MIRNA	MIRNA:hsa-mir-3119	hsa-mir-3119	hsa-mir-3119	33	5.388568e-05	1
MIRNA	MIRNA:hsa-mir-299-5p	hsa-mir-299-5p	hsa-mir-299-5p	24	5.736282e-05	1
MIRNA	MIRNA:hsa-mir-92a-3p	hsa-mir-92a-3p	hsa-mir-92a-3p	35	6.575536e-05	1
MIRNA	MIRNA:hsa-mir-144	hsa-mir-144	hsa-mir-144	38	7.362376e-05	1
MIRNA	MIRNA:hsa-mir-3163	hsa-mir-3163	hsa-mir-3163	53	1.317769e-04	1
MIRNA	MIRNA:hsa-mir-524-5p	hsa-mir-524-5p	hsa-mir-524-5p	47	1.387614e-04	1
MIRNA	MIRNA:hsa-mir-520d-5p	hsa-mir-520d-5p	hsa-mir-520d-5p	47	1.407392e-04	1
MIRNA	MIRNA:hsa-mir-363	hsa-mir-363	hsa-mir-363	34	1.706839e-04	1
MIRNA	MIRNA:hsa-mir-25	hsa-mir-25	hsa-mir-25	34	1.706839e-04	1
MIRNA	MIRNA:hsa-mir-32	hsa-mir-32	hsa-mir-32	34	1.706839e-04	1
MIRNA	MIRNA:hsa-mir-367	hsa-mir-367	hsa-mir-367	34	1.706839e-04	1
MIRNA	MIRNA:hsa-mir-92b	hsa-mir-92b	hsa-mir-92b	34	1.706839e-04	1
MIRNA	MIRNA:hsa-mir-92a	hsa-mir-92a	hsa-mir-92a	34	1.706839e-04	1
MIRNA	MIRNA:hsa-mir-3160-5p	hsa-mir-3160-5p	hsa-mir-3160-5p	31	1.789506e-04	1
MIRNA	MIRNA:hsa-mir-4672	hsa-mir-4672	hsa-mir-4672	38	1.825635e-04	1
MIRNA	MIRNA:hsa-mir-3662	hsa-mir-3662	hsa-mir-3662	49	2.060528e-04	1
MIRNA	MIRNA:hsa-mir-17-5p	hsa-mir-17-5p	hsa-mir-17-5p	31	2.768987e-04	1
MIRNA	MIRNA:hsa-mir-4668-5p	hsa-mir-4668-5p	hsa-mir-4668-5p	44	3.344526e-04	1
MIRNA	MIRNA:hsa-mir-186	hsa-mir-186	hsa-mir-186	39	3.548863e-04	1
MIRNA	MIRNA:hsa-mir-570	hsa-mir-570	hsa-mir-570	43	3.667927e-04	1
MIRNA	MIRNA:hsa-mir-30d	hsa-mir-30d	hsa-mir-30d	34	4.267746e-04	1
MIRNA	MIRNA:hsa-mir-30e	hsa-mir-30e	hsa-mir-30e	34	4.267746e-04	1
MIRNA	MIRNA:hsa-mir-30b	hsa-mir-30b	hsa-mir-30b	34	4.267746e-04	1
MIRNA	MIRNA:hsa-mir-30a	hsa-mir-30a	hsa-mir-30a	34	4.267746e-04	1
MIRNA	MIRNA:hsa-mir-30c	hsa-mir-30c	hsa-mir-30c	34	4.267746e-04	1
MIRNA	MIRNA:hsa-mir-9	hsa-mir-9	hsa-mir-9	29	4.603763e-04	1
MIRNA	MIRNA:hsa-mir-101	hsa-mir-101	hsa-mir-101	34	5.075780e-04	1
MIRNA	MIRNA:hsa-mir-3692	hsa-mir-3692	hsa-mir-3692	33	5.767170e-04	1
MIRNA	MIRNA:hsa-mir-7	hsa-mir-7	hsa-mir-7	32	6.050584e-04	1
MIRNA	MIRNA:hsa-mir-4698	hsa-mir-4698	hsa-mir-4698	44	6.092514e-04	1
MIRNA	MIRNA:hsa-mir-3613-3p	hsa-mir-3613-3p	hsa-mir-3613-3p	56	6.258086e-04	1
MIRNA	MIRNA:hsa-mir-548b-3p	hsa-mir-548b-3p	hsa-mir-548b-3p	25	6.324835e-04	1
MIRNA	MIRNA:hsa-mir-548aj	hsa-mir-548aj	hsa-mir-548aj	41	6.342148e-04	1
MIRNA	MIRNA:hsa-mir-548ae	hsa-mir-548ae	hsa-mir-548ae	41	6.342148e-04	1
MIRNA	MIRNA:hsa-mir-548x	hsa-mir-548x	hsa-mir-548x	41	6.342148e-04	1
MIRNA	MIRNA:hsa-mir-548am	hsa-mir-548am	hsa-mir-548am	41	6.342148e-04	1
MIRNA	MIRNA:hsa-mir-195	hsa-mir-195	hsa-mir-195	44	6.523456e-04	1
MIRNA	MIRNA:hsa-mir-16	hsa-mir-16	hsa-mir-16	44	6.523456e-04	1
MIRNA	MIRNA:hsa-mir-15b	hsa-mir-15b	hsa-mir-15b	44	6.523456e-04	1
MIRNA	MIRNA:hsa-mir-497	hsa-mir-497	hsa-mir-497	44	6.523456e-04	1
MIRNA	MIRNA:hsa-mir-424	hsa-mir-424	hsa-mir-424	44	6.523456e-04	1
MIRNA	MIRNA:hsa-mir-15a	hsa-mir-15a	hsa-mir-15a	44	6.523456e-04	1
MIRNA	MIRNA:hsa-mir-545	hsa-mir-545	hsa-mir-545	39	6.556556e-04	1
MIRNA	MIRNA:hsa-mir-615-3p	hsa-mir-615-3p	hsa-mir-615-3p	27	6.589478e-04	1
MIRNA	MIRNA:hsa-mir-4729	hsa-mir-4729	hsa-mir-4729	41	6.816821e-04	1
MIRNA	MIRNA:hsa-mir-3658	hsa-mir-3658	hsa-mir-3658	36	8.139324e-04	1
MIRNA	MIRNA:hsa-mir-3685	hsa-mir-3685	hsa-mir-3685	28	1.092965e-03	1
MIRNA	MIRNA:hsa-mir-488	hsa-mir-488	hsa-mir-488	30	1.101320e-03	1
MIRNA	MIRNA:hsa-mir-3148	hsa-mir-3148	hsa-mir-3148	46	1.105621e-03	1
MIRNA	MIRNA:hsa-mir-20a-5p	hsa-mir-20a-5p	hsa-mir-20a-5p	28	1.252142e-03	1
MIRNA	MIRNA:hsa-mir-877-3p	hsa-mir-877-3p	hsa-mir-877-3p	20	1.298213e-03	1
MIRNA	MIRNA:hsa-mir-3646	hsa-mir-3646	hsa-mir-3646	42	1.432756e-03	1
MIRNA	MIRNA:hsa-mir-548t	hsa-mir-548t	hsa-mir-548t	37	1.447944e-03	1
MIRNA	MIRNA:hsa-mir-3919	hsa-mir-3919	hsa-mir-3919	39	1.645137e-03	1
MIRNA	MIRNA:hsa-mir-338-5p	hsa-mir-338-5p	hsa-mir-338-5p	33	1.845218e-03	1
MIRNA	MIRNA:hsa-mir-127-5p	hsa-mir-127-5p	hsa-mir-127-5p	24	1.858386e-03	1
MIRNA	MIRNA:hsa-mir-519d-3p	hsa-mir-519d-3p	hsa-mir-519d-3p	25	1.959810e-03	1
MIRNA	MIRNA:hsa-mir-659	hsa-mir-659	hsa-mir-659	26	2.317613e-03	1
MIRNA	MIRNA:hsa-mir-20b-5p	hsa-mir-20b-5p	hsa-mir-20b-5p	25	2.359847e-03	1
MIRNA	MIRNA:hsa-mir-93	hsa-mir-93	hsa-mir-93	42	2.401198e-03	1
MIRNA	MIRNA:hsa-mir-20a	hsa-mir-20a	hsa-mir-20a	42	2.401198e-03	1
MIRNA	MIRNA:hsa-mir-106a	hsa-mir-106a	hsa-mir-106a	42	2.401198e-03	1
MIRNA	MIRNA:hsa-mir-519d	hsa-mir-519d	hsa-mir-519d	42	2.401198e-03	1
MIRNA	MIRNA:hsa-mir-17	hsa-mir-17	hsa-mir-17	42	2.401198e-03	1
MIRNA	MIRNA:hsa-mir-106b	hsa-mir-106b	hsa-mir-106b	42	2.401198e-03	1
MIRNA	MIRNA:hsa-mir-20b	hsa-mir-20b	hsa-mir-20b	42	2.401198e-03	1
MIRNA	MIRNA:hsa-mir-1290	hsa-mir-1290	hsa-mir-1290	28	2.465953e-03	1
MIRNA	MIRNA:hsa-mir-543	hsa-mir-543	hsa-mir-543	36	2.558217e-03	1
MIRNA	MIRNA:hsa-mir-142-5p	hsa-mir-142-5p	hsa-mir-142-5p	33	2.581051e-03	1
MIRNA	MIRNA:hsa-mir-361-5p	hsa-mir-361-5p	hsa-mir-361-5p	26	2.711704e-03	1
MIRNA	MIRNA:hsa-mir-3160-3p	hsa-mir-3160-3p	hsa-mir-3160-3p	30	2.714384e-03	1
MIRNA	MIRNA:hsa-mir-203	hsa-mir-203	hsa-mir-203	35	2.808047e-03	1
MIRNA	MIRNA:hsa-mir-548v	hsa-mir-548v	hsa-mir-548v	25	2.833627e-03	1
MIRNA	MIRNA:hsa-mir-4427	hsa-mir-4427	hsa-mir-4427	28	2.853227e-03	1
MIRNA	MIRNA:hsa-mir-494	hsa-mir-494	hsa-mir-494	37	3.650601e-03	1
MIRNA	MIRNA:hsa-mir-153	hsa-mir-153	hsa-mir-153	22	5.011020e-03	1
MIRNA	MIRNA:hsa-mir-4302	hsa-mir-4302	hsa-mir-4302	30	5.033625e-03	1
MIRNA	MIRNA:hsa-mir-514b-5p	hsa-mir-514b-5p	hsa-mir-514b-5p	29	6.342518e-03	1
MIRNA	MIRNA:hsa-mir-513c	hsa-mir-513c	hsa-mir-513c	28	6.616648e-03	1
MIRNA	MIRNA:hsa-mir-155-5p	hsa-mir-155-5p	hsa-mir-155-5p	24	6.793168e-03	1
MIRNA	MIRNA:hsa-mir-3671	hsa-mir-3671	hsa-mir-3671	36	6.795768e-03	1
MIRNA	MIRNA:hsa-mir-107	hsa-mir-107	hsa-mir-107	36	7.079565e-03	1
MIRNA	MIRNA:hsa-mir-4422	hsa-mir-4422	hsa-mir-4422	34	7.292149e-03	1
MIRNA	MIRNA:hsa-mir-4524	hsa-mir-4524	hsa-mir-4524	25	7.601403e-03	1
MIRNA	MIRNA:hsa-mir-1285	hsa-mir-1285	hsa-mir-1285	38	8.634017e-03	1
MIRNA	MIRNA:hsa-mir-579	hsa-mir-579	hsa-mir-579	40	9.099501e-03	1
MIRNA	MIRNA:hsa-mir-181b	hsa-mir-181b	hsa-mir-181b	36	9.520047e-03	1
MIRNA	MIRNA:hsa-mir-181d	hsa-mir-181d	hsa-mir-181d	36	9.520047e-03	1
MIRNA	MIRNA:hsa-mir-181c	hsa-mir-181c	hsa-mir-181c	36	9.520047e-03	1
MIRNA	MIRNA:hsa-mir-4652-3p	hsa-mir-4652-3p	hsa-mir-4652-3p	35	9.567445e-03	1
MIRNA	MIRNA:hsa-mir-181a	hsa-mir-181a	hsa-mir-181a	36	9.647551e-03	1
MIRNA	MIRNA:hsa-mir-103a	hsa-mir-103a	hsa-mir-103a	34	9.663123e-03	1
MIRNA	MIRNA:hsa-mir-4677-5p	hsa-mir-4677-5p	hsa-mir-4677-5p	27	9.781734e-03	1
MIRNA	MIRNA:hsa-mir-3942-5p	hsa-mir-3942-5p	hsa-mir-3942-5p	25	1.000675e-02	1
MIRNA	MIRNA:hsa-mir-3134	hsa-mir-3134	hsa-mir-3134	20	1.004322e-02	1
MIRNA	MIRNA:hsa-mir-4703-5p	hsa-mir-4703-5p	hsa-mir-4703-5p	25	1.037518e-02	1
MIRNA	MIRNA:hsa-mir-3619-5p	hsa-mir-3619-5p	hsa-mir-3619-5p	41	1.085144e-02	1
MIRNA	MIRNA:hsa-mir-330-3p	hsa-mir-330-3p	hsa-mir-330-3p	34	1.094621e-02	1
MIRNA	MIRNA:hsa-mir-761	hsa-mir-761	hsa-mir-761	41	1.111297e-02	1
MIRNA	MIRNA:hsa-mir-4511	hsa-mir-4511	hsa-mir-4511	26	1.116254e-02	1
MIRNA	MIRNA:hsa-mir-4311	hsa-mir-4311	hsa-mir-4311	33	1.300172e-02	1
MIRNA	MIRNA:hsa-mir-19a	hsa-mir-19a	hsa-mir-19a	29	1.322728e-02	1
MIRNA	MIRNA:hsa-mir-19b	hsa-mir-19b	hsa-mir-19b	29	1.322728e-02	1
MIRNA	MIRNA:hsa-mir-3120-3p	hsa-mir-3120-3p	hsa-mir-3120-3p	38	1.394593e-02	1
MIRNA	MIRNA:hsa-mir-300	hsa-mir-300	hsa-mir-300	32	1.582697e-02	1
MIRNA	MIRNA:hsa-mir-548n	hsa-mir-548n	hsa-mir-548n	37	1.606507e-02	1
MIRNA	MIRNA:hsa-mir-384	hsa-mir-384	hsa-mir-384	26	1.678395e-02	1
MIRNA	MIRNA:hsa-mir-194	hsa-mir-194	hsa-mir-194	25	1.730330e-02	1
MIRNA	MIRNA:hsa-mir-4262	hsa-mir-4262	hsa-mir-4262	36	1.821363e-02	1
MIRNA	MIRNA:hsa-mir-4527	hsa-mir-4527	hsa-mir-4527	19	1.828799e-02	1
MIRNA	MIRNA:hsa-mir-214	hsa-mir-214	hsa-mir-214	40	1.844784e-02	1
MIRNA	MIRNA:hsa-mir-3146	hsa-mir-3146	hsa-mir-3146	16	1.850310e-02	1
MIRNA	MIRNA:hsa-mir-708	hsa-mir-708	hsa-mir-708	22	1.967620e-02	1
MIRNA	MIRNA:hsa-mir-450b-5p	hsa-mir-450b-5p	hsa-mir-450b-5p	32	2.032880e-02	1
MIRNA	MIRNA:hsa-mir-3187-5p	hsa-mir-3187-5p	hsa-mir-3187-5p	38	2.060549e-02	1
MIRNA	MIRNA:hsa-mir-612	hsa-mir-612	hsa-mir-612	38	2.136049e-02	1
MIRNA	MIRNA:hsa-mir-646	hsa-mir-646	hsa-mir-646	34	2.140687e-02	1
MIRNA	MIRNA:hsa-mir-151-3p	hsa-mir-151-3p	hsa-mir-151-3p	16	2.166625e-02	1
MIRNA	MIRNA:hsa-mir-3921	hsa-mir-3921	hsa-mir-3921	27	2.178206e-02	1
MIRNA	MIRNA:hsa-mir-3065-5p	hsa-mir-3065-5p	hsa-mir-3065-5p	33	2.182738e-02	1
MIRNA	MIRNA:hsa-mir-4653-5p	hsa-mir-4653-5p	hsa-mir-4653-5p	27	2.212802e-02	1
MIRNA	MIRNA:hsa-mir-381	hsa-mir-381	hsa-mir-381	31	2.242668e-02	1
MIRNA	MIRNA:hsa-mir-4659a-3p	hsa-mir-4659a-3p	hsa-mir-4659a-3p	39	2.277176e-02	1
MIRNA	MIRNA:hsa-mir-4659b-3p	hsa-mir-4659b-3p	hsa-mir-4659b-3p	39	2.277176e-02	1
MIRNA	MIRNA:hsa-mir-21-5p	hsa-mir-21-5p	hsa-mir-21-5p	18	2.318581e-02	1
MIRNA	MIRNA:hsa-mir-4766-5p	hsa-mir-4766-5p	hsa-mir-4766-5p	32	2.427830e-02	1
MIRNA	MIRNA:hsa-mir-4699-3p	hsa-mir-4699-3p	hsa-mir-4699-3p	33	2.459769e-02	1
MIRNA	MIRNA:hsa-mir-371-5p	hsa-mir-371-5p	hsa-mir-371-5p	37	2.530427e-02	1
MIRNA	MIRNA:hsa-mir-4328	hsa-mir-4328	hsa-mir-4328	37	2.561102e-02	1
MIRNA	MIRNA:hsa-mir-4282	hsa-mir-4282	hsa-mir-4282	43	2.562800e-02	1
MIRNA	MIRNA:hsa-mir-103b	hsa-mir-103b	hsa-mir-103b	17	2.580340e-02	1
MIRNA	MIRNA:hsa-mir-3139	hsa-mir-3139	hsa-mir-3139	22	2.660863e-02	1
MIRNA	MIRNA:hsa-mir-3973	hsa-mir-3973	hsa-mir-3973	31	2.723903e-02	1
MIRNA	MIRNA:hsa-mir-4521	hsa-mir-4521	hsa-mir-4521	19	2.765033e-02	1
MIRNA	MIRNA:hsa-mir-548an	hsa-mir-548an	hsa-mir-548an	32	2.815508e-02	1
MIRNA	MIRNA:hsa-mir-324-3p	hsa-mir-324-3p	hsa-mir-324-3p	33	2.916959e-02	1
MIRNA	MIRNA:hsa-mir-4642	hsa-mir-4642	hsa-mir-4642	23	2.968928e-02	1
MIRNA	MIRNA:hsa-mir-4424	hsa-mir-4424	hsa-mir-4424	20	3.026843e-02	1
MIRNA	MIRNA:hsa-mir-1279	hsa-mir-1279	hsa-mir-1279	24	3.067004e-02	1
MIRNA	MIRNA:hsa-mir-544	hsa-mir-544	hsa-mir-544	28	3.312832e-02	1
MIRNA	MIRNA:hsa-mir-4445	hsa-mir-4445	hsa-mir-4445	17	3.425854e-02	1
MIRNA	MIRNA:hsa-mir-648	hsa-mir-648	hsa-mir-648	18	3.625328e-02	1
MIRNA	MIRNA:hsa-mir-548p	hsa-mir-548p	hsa-mir-548p	35	3.655172e-02	1
MIRNA	MIRNA:hsa-mir-4680-3p	hsa-mir-4680-3p	hsa-mir-4680-3p	27	3.676216e-02	1
MIRNA	MIRNA:hsa-mir-4756-3p	hsa-mir-4756-3p	hsa-mir-4756-3p	30	3.744061e-02	1
MIRNA	MIRNA:hsa-mir-3156-5p	hsa-mir-3156-5p	hsa-mir-3156-5p	18	3.786603e-02	1
MIRNA	MIRNA:hsa-mir-138	hsa-mir-138	hsa-mir-138	23	3.789927e-02	1
MIRNA	MIRNA:hsa-mir-193a-3p	hsa-mir-193a-3p	hsa-mir-193a-3p	21	3.804435e-02	1
MIRNA	MIRNA:hsa-mir-326	hsa-mir-326	hsa-mir-326	30	3.901378e-02	1
MIRNA	MIRNA:hsa-mir-3200-3p	hsa-mir-3200-3p	hsa-mir-3200-3p	15	3.944525e-02	1
MIRNA	MIRNA:hsa-mir-28-5p	hsa-mir-28-5p	hsa-mir-28-5p	22	4.116597e-02	1
MIRNA	MIRNA:hsa-mir-548ag	hsa-mir-548ag	hsa-mir-548ag	22	4.116597e-02	1
MIRNA	MIRNA:hsa-mir-548ai	hsa-mir-548ai	hsa-mir-548ai	22	4.116597e-02	1
MIRNA	MIRNA:hsa-mir-301a	hsa-mir-301a	hsa-mir-301a	28	4.242231e-02	1
MIRNA	MIRNA:hsa-mir-454	hsa-mir-454	hsa-mir-454	28	4.242231e-02	1
MIRNA	MIRNA:hsa-mir-130b	hsa-mir-130b	hsa-mir-130b	28	4.242231e-02	1
MIRNA	MIRNA:hsa-mir-301b	hsa-mir-301b	hsa-mir-301b	28	4.242231e-02	1
MIRNA	MIRNA:hsa-mir-130a	hsa-mir-130a	hsa-mir-130a	28	4.242231e-02	1
MIRNA	MIRNA:hsa-mir-2116	hsa-mir-2116	hsa-mir-2116	23	4.345911e-02	1
MIRNA	MIRNA:hsa-mir-362-5p	hsa-mir-362-5p	hsa-mir-362-5p	19	4.456810e-02	1
MIRNA	MIRNA:hsa-mir-3614-5p	hsa-mir-3614-5p	hsa-mir-3614-5p	31	4.483208e-02	1
MIRNA	MIRNA:hsa-mir-4778-5p	hsa-mir-4778-5p	hsa-mir-4778-5p	27	4.594683e-02	1
MIRNA	MIRNA:hsa-mir-3688-3p	hsa-mir-3688-3p	hsa-mir-3688-3p	28	4.756494e-02	1
MIRNA	MIRNA:hsa-mir-409-5p	hsa-mir-409-5p	hsa-mir-409-5p	14	4.802937e-02	1
MIRNA	MIRNA:hsa-mir-720	hsa-mir-720	hsa-mir-720	14	4.936164e-02	1
MIRNA	MIRNA:hsa-mir-3617	hsa-mir-3617	hsa-mir-3617	28	4.963456e-02	1

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5376	17p13 3 YWHAE copy number variation	17p13 3 YWHAE copy number variation	7	3.543284e-07	1
WP	WP:WP4560	MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement	MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement	6	5.368718e-06	1
WP	WP:WP4534	Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms	Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms	6	2.091868e-03	1
WP	WP:WP5502	16p13 11 copy number variation syndrome	16p13 11 copy number variation syndrome	5	2.841920e-03	1
WP	WP:WP51	Regulation of actin cytoskeleton	Regulation of actin cytoskeleton	9	8.113598e-03	1
WP	WP:WP2572	Primary focal segmental glomerulosclerosis FSGS	Primary focal segmental glomerulosclerosis FSGS	6	2.746667e-02	1
WP	WP:WP5426	HDAC6 interactions in the central nervous system	HDAC6 interactions in the central nervous system	7	4.728835e-02	1

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04390	Hippo signaling pathway	Hippo signaling pathway	12	0.000002	1
KEGG	KEGG:05100	Bacterial invasion of epithelial cells	Bacterial invasion of epithelial cells	9	0.000003	1
KEGG	KEGG:04520	Adherens junction	Adherens junction	8	0.000208	1
KEGG	KEGG:04670	Leukocyte transendothelial migration	Leukocyte transendothelial migration	8	0.000958	1
KEGG	KEGG:05131	Shigellosis	Shigellosis	11	0.001549	1
KEGG	KEGG:04810	Regulation of actin cytoskeleton	Regulation of actin cytoskeleton	10	0.004382	1
KEGG	KEGG:04015	Rap1 signaling pathway	Rap1 signaling pathway	9	0.013222	1
KEGG	KEGG:04814	Motor proteins	Motor proteins	8	0.039416	1

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:5177	Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)	Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)	4	0.000572	1
CORUM	CORUM:5199	Kinase maturation complex 1	Kinase maturation complex 1	4	0.026102	1
CORUM	CORUM:6925	MAPK1-PTK2-PXN complex	MAPK1-PTK2-PXN complex	2	0.049944	1
CORUM	CORUM:7345	DISC1-TRAK1 complex	DISC1-TRAK1 complex	2	0.049944	1
CORUM	CORUM:5282	CAS-SRC-FAK complex	CAS-SRC-FAK complex	2	0.049944	1
CORUM	CORUM:6916	CTTN-FER-PTK2 complex	CTTN-FER-PTK2 complex	2	0.049944	1

HP

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0030192	Fatigable weakness of bulbar muscles	A type of weakness of the bulbar muscles (muscles of the mouth and throat responsible for speech and swallowing) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	7	0.010083	1
HP	HP:0001283	Bulbar palsy	Bulbar weakness (or bulbar palsy) refers to bilateral impairment of function of the lower cranial nerves IX, X, XI and XII, which occurs due to lower motor neuron lesion either at nuclear or fascicular level in the medulla or from bilateral lesions of the lower cranial nerves outside the brain-stem. Bulbar weakness is often associated with difficulty in chewing, weakness of the facial muscles, dysarthria, palatal weakness and regurgitation of fluids, dysphagia, and dysphonia.	6	0.013253	1
HP	HP:0003473	Fatigable weakness	A type of weakness that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	9	0.015853	1
HP	HP:0003398	Abnormal synaptic transmission at the neuromuscular junction	Any abnormality of the neuromuscular junction, which is the synapse between the motor end plate of a motor neuron and the skeletal muscle fibers.	9	0.016967	1
HP	HP:0030191	Abnormal peripheral nervous system synaptic transmission	An anomaly in the communication from a neuron to a target across a synapse in the peripheral nervous system.	9	0.016967	1
HP	HP:0012535	Abnormal synaptic transmission	An anomaly in the communication from a neuron to a target across a synapse. This is a four step process, comprising (i) synthesis and storage of neurotransmitters; (ii) neurotransmitter release; (iii) activation of postsynaptic receptors by the neurotransmitter; and (iv) inactivation of the neurotransmitter. Thus, this term is defined as an anomaly of neurotransmitter metabolic process.	9	0.016967	1
HP	HP:0002145	Frontotemporal dementia	A dementia associated with degeneration of the frontotemporal lobe and clinically associated with personality and behavioral changes such as disinhibition, apathy, and lack of insight. The hallmark feature of frontotemporal dementia is the presentation with focal syndromes such as progressive language dysfunction, or aphasia, or behavioral changes characteristic of frontal lobe disorders.	6	0.037262	1
HP	HP:0002450	Abnormal motor neuron morphology	Any structural anomaly that affects the motor neuron.	7	0.040234	1
HP	HP:0012473	Tongue atrophy	Wasting of the tongue.	6	0.041838	1
HP	HP:0012764	Orthopnea	A sensation of breathlessness in the recumbent position, relieved by sitting or standing.	8	0.049174	1

Community 2

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	147	2.274198e-19	2
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	96	5.518203e-18	2
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	56	6.373946e-16	2
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	56	1.215074e-15	2
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	56	1.241240e-15	2
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	56	1.241240e-15	2
GO:CC	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	51	6.514916e-15	2
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	75	6.101672e-14	2
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	60	1.151756e-09	2
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	159	4.197217e-09	2
GO:CC	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	148	8.508796e-08	2
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	87	1.172451e-07	2
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	87	1.172451e-07	2
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	87	1.172451e-07	2
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	153	1.914473e-07	2
GO:CC	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	62	3.875878e-06	2
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	43	3.362746e-05	2
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	43	3.593903e-05	2
GO:CC	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	17	7.686323e-05	2
GO:CC	GO:0099073	mitochondrion-derived vesicle	"A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:18207745, PMID:20619655, PMID:22226745, PMID:23300790]	3	1.207898e-04	2
GO:CC	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	63	2.555657e-04	2
GO:CC	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	53	4.439471e-04	2
GO:CC	GO:0005662	DNA replication factor A complex	"A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]	4	5.889554e-04	2
GO:CC	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	134	8.900917e-04	2
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	14	1.003535e-03	2
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	14	1.310676e-03	2
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	141	3.335175e-03	2
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	20	3.743298e-03	2
GO:CC	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	8	3.882203e-03	2
GO:CC	GO:0042579	microbody	"Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732]	8	3.882203e-03	2
GO:CC	GO:0005740	mitochondrial envelope	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]	19	4.096906e-03	2
GO:CC	GO:0043601	nuclear replisome	"A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu]	4	5.723692e-03	2
GO:CC	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	18	6.380451e-03	2
GO:CC	GO:0042470	melanosome	"A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]	7	6.604082e-03	2
GO:CC	GO:0048770	pigment granule	"A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]	7	6.604082e-03	2
GO:CC	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	7	7.392962e-03	2
GO:CC	GO:0030894	replisome	"A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]	4	8.220130e-03	2
GO:CC	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	17	1.095959e-02	2
GO:CC	GO:1904813	ficolin-1-rich granule lumen	"Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620]	7	1.136678e-02	2
GO:CC	GO:0031967	organelle envelope	"A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz]	24	1.177699e-02	2
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	35	1.574061e-02	2
GO:CC	GO:1902687	glucosidase complex	"A protein complex which is capable of glucosidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932]	2	1.671957e-02	2
GO:CC	GO:0017177	glucosidase II complex	"A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335]	2	1.671957e-02	2
GO:CC	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	33	2.431502e-02	2
GO:CC	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	6	2.651181e-02	2
GO:CC	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	3	3.273271e-02	2
GO:CC	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	7	3.341540e-02	2
GO:CC	GO:0031903	microbody membrane	"The lipid bilayer surrounding a microbody." [GOC:mah]	5	4.144651e-02	2
GO:CC	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	5	4.144651e-02	2

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0006753	nucleoside phosphate metabolic process	"The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah]	31	1.748125e-13	2
GO:BP	GO:0055086	nucleobase-containing small molecule metabolic process	"The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw]	31	5.453225e-13	2
GO:BP	GO:0072521	purine-containing compound metabolic process	"The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	27	2.145759e-11	2
GO:BP	GO:0009117	nucleotide metabolic process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]	25	6.512361e-11	2
GO:BP	GO:0019637	organophosphate metabolic process	"The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]	35	1.891055e-10	2
GO:BP	GO:0006163	purine nucleotide metabolic process	"The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	23	2.475741e-10	2
GO:BP	GO:0009056	catabolic process	"A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	55	5.238152e-10	2
GO:BP	GO:0044281	small molecule metabolic process	"The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	44	9.209006e-10	2
GO:BP	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	43	1.068606e-08	2
GO:BP	GO:0019693	ribose phosphate metabolic process	"The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]	20	1.457738e-08	2
GO:BP	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	30	6.851525e-08	2
GO:BP	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	65	7.109258e-08	2
GO:BP	GO:0006091	generation of precursor metabolites and energy	"The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]	21	1.246370e-07	2
GO:BP	GO:0046390	ribose phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]	14	1.767451e-07	2
GO:BP	GO:1901293	nucleoside phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie]	17	3.807832e-07	2
GO:BP	GO:0009259	ribonucleotide metabolic process	"The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	18	6.716282e-07	2
GO:BP	GO:0009150	purine ribonucleotide metabolic process	"The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	17	2.096102e-06	2
GO:BP	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	22	2.333543e-06	2
GO:BP	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	45	5.609796e-06	2
GO:BP	GO:0006793	phosphorus metabolic process	"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]	45	5.833430e-06	2
GO:BP	GO:0006734	NADH metabolic process	"The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	7	8.860427e-06	2
GO:BP	GO:0072524	pyridine-containing compound metabolic process	"The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]	12	9.404768e-06	2
GO:BP	GO:0015980	energy derivation by oxidation of organic compounds	"The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah]	16	1.226101e-05	2
GO:BP	GO:0009260	ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	12	1.487601e-05	2
GO:BP	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	25	1.774805e-05	2
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	67	2.061843e-05	2
GO:BP	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	33	2.149372e-05	2
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	32	2.519984e-05	2
GO:BP	GO:0043436	oxoacid metabolic process	"The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid]	25	2.877852e-05	2
GO:BP	GO:0009165	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	13	3.167757e-05	2
GO:BP	GO:0006082	organic acid metabolic process	"The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]	25	3.274644e-05	2
GO:BP	GO:0009141	nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	14	3.660527e-05	2
GO:BP	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	11	6.205376e-05	2
GO:BP	GO:0019362	pyridine nucleotide metabolic process	"The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl]	11	6.615054e-05	2
GO:BP	GO:0046496	nicotinamide nucleotide metabolic process	"The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732]	11	6.615054e-05	2
GO:BP	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	19	7.306045e-05	2
GO:BP	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	38	7.532420e-05	2
GO:BP	GO:0008219	cell death	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]	38	7.942842e-05	2
GO:BP	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]	124	9.575181e-05	2
GO:BP	GO:0009199	ribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	13	1.411582e-04	2
GO:BP	GO:0009144	purine nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	13	1.411582e-04	2
GO:BP	GO:1901137	carbohydrate derivative biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]	19	1.785628e-04	2
GO:BP	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	13	2.187697e-04	2
GO:BP	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	16	3.033158e-04	2
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	45	3.906197e-04	2
GO:BP	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	11	3.942058e-04	2
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	45	4.426287e-04	2
GO:BP	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	30	4.763635e-04	2
GO:BP	GO:0006520	amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732]	13	6.528946e-04	2
GO:BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	12	7.970593e-04	2
GO:BP	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	98	9.246478e-04	2
GO:BP	GO:0072522	purine-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	12	9.417953e-04	2
GO:BP	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	35	9.616441e-04	2
GO:BP	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	35	9.616441e-04	2
GO:BP	GO:0016236	macroautophagy	"The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]	14	1.020688e-03	2
GO:BP	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	19	1.595546e-03	2
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	48	1.873317e-03	2
GO:BP	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	11	1.892471e-03	2
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	28	2.064882e-03	2
GO:BP	GO:0046034	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	11	2.153489e-03	2
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	52	2.243027e-03	2
GO:BP	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	84	2.812132e-03	2
GO:BP	GO:0043067	regulation of programmed cell death	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	29	3.631833e-03	2
GO:BP	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	13	3.726203e-03	2
GO:BP	GO:0005996	monosaccharide metabolic process	"The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732]	11	5.048226e-03	2
GO:BP	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	12	5.093715e-03	2
GO:BP	GO:0008152	metabolic process	"A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	131	5.911544e-03	2
GO:BP	GO:2001245	regulation of phosphatidylcholine biosynthetic process	"Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol]	3	6.965232e-03	2
GO:BP	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	12	7.115010e-03	2
GO:BP	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	21	7.223845e-03	2
GO:BP	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	17	7.259206e-03	2
GO:BP	GO:0036293	response to decreased oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al]	12	8.103219e-03	2
GO:BP	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions." [PMID:28648096]	5	8.770637e-03	2
GO:BP	GO:0009142	nucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	8.807982e-03	2
GO:BP	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	12	8.921754e-03	2
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	33	9.176225e-03	2
GO:BP	GO:0046364	monosaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732]	7	9.339604e-03	2
GO:BP	GO:0070585	protein localization to mitochondrion	"A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd]	8	1.172615e-02	2
GO:BP	GO:0170033	L-amino acid metabolic process	"The chemical reactions and pathways involving an L-amino acid." [GOC:edw]	9	1.184492e-02	2
GO:BP	GO:0043490	malate-aspartate shuttle	"The process of transferring reducing equivalents from NADH in the cytosol to the mitochondria via malate. Cytosolic aspartate aminotransferase converts aspartate to oxaloacetate, and cytosolic malate dehydrogenase uses NADH to convert oxaloacetate to malate in the cytosol; the malate-alpha-ketoglutarate carrier then transports the malate into the mitochondria where mitochondrial malate dehydrogenase uses NAD to convert malate back to oxaloacetate; the electrons on the reduced NADH are then available for use in the electron transport chain; mitochondrial aspartate aminotransferase converts oxaloacetate to aspartate, and the glutamate-aspartate carrier transports the aspartate back to the cytosol to complete the cycle." [GOC:sjm, PMID:16368075]	3	1.385398e-02	2
GO:BP	GO:0010042	response to manganese ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:sm]	4	1.454823e-02	2
GO:BP	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	8	1.461396e-02	2
GO:BP	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	49	1.692347e-02	2
GO:BP	GO:0006006	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	9	1.775539e-02	2
GO:BP	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	16	1.840868e-02	2
GO:BP	GO:0061919	process utilizing autophagic mechanism	"A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378]	16	1.840868e-02	2
GO:BP	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	12	1.909779e-02	2
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	33	1.996670e-02	2
GO:BP	GO:0008637	apoptotic mitochondrial changes	"The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis]	7	2.121622e-02	2
GO:BP	GO:0045333	cellular respiration	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732]	10	2.493198e-02	2
GO:BP	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	9	2.496627e-02	2
GO:BP	GO:0009167	purine ribonucleoside monophosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	5	2.555296e-02	2
GO:BP	GO:0009126	purine nucleoside monophosphate metabolic process	"The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	5	3.223231e-02	2
GO:BP	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	5	4.019729e-02	2
GO:BP	GO:0010821	regulation of mitochondrion organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]	7	4.353976e-02	2
GO:BP	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	22	4.384335e-02	2
GO:BP	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	21	4.822292e-02	2

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	105	6.638597e-13	2
GO:MF	GO:0036094	small molecule binding	"Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]	90	1.270857e-06	2
GO:MF	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-]	13	1.449589e-06	2
GO:MF	GO:0043167	ion binding	"Binding to an ion, a charged atoms or groups of atoms." [GOC:jl]	85	2.485605e-05	2
GO:MF	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	35	7.132453e-05	2
GO:MF	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	44	7.996426e-05	2
GO:MF	GO:0017076	purine nucleotide binding	"Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]	42	8.738831e-05	2
GO:MF	GO:1901265	nucleoside phosphate binding	"Binding to nucleoside phosphate." [GOC:TermGenie]	44	9.913278e-05	2
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	148	1.170407e-04	2
GO:MF	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-]	22	1.544063e-04	2
GO:MF	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	45	1.688044e-04	2
GO:MF	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	46	2.554993e-04	2
GO:MF	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	163	2.932150e-04	2
GO:MF	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	52	2.976271e-04	2
GO:MF	GO:0004177	aminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain." [EC:3.4.11.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]	6	5.002152e-04	2
GO:MF	GO:0035639	purine ribonucleoside triphosphate binding	"Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732]	38	8.572214e-04	2
GO:MF	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	31	9.695350e-04	2
GO:MF	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	5	1.141179e-03	2
GO:MF	GO:0005536	D-glucose binding	"Binding to D-enantiomers of glucose." [GOC:jl]	4	1.466215e-03	2
GO:MF	GO:0032555	purine ribonucleotide binding	"Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	38	1.707970e-03	2
GO:MF	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	31	1.718770e-03	2
GO:MF	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	7	2.032818e-03	2
GO:MF	GO:0032553	ribonucleotide binding	"Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	38	2.064485e-03	2
GO:MF	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	7	2.221090e-03	2
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	13	2.583865e-03	2
GO:MF	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	37	6.478928e-03	2
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	36	7.493353e-03	2
GO:MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	8	1.008715e-02	2
GO:MF	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	16	1.039406e-02	2
GO:MF	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	6	1.164388e-02	2
GO:MF	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	40	1.428233e-02	2
GO:MF	GO:0016879	ligase activity, forming carbon-nitrogen bonds	"Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3.-.-]	5	3.868819e-02	2
GO:MF	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	7	4.571595e-02	2
GO:MF	GO:0140431	DNA-(abasic site) binding	"Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base." [PMID:23245849]	2	4.955669e-02	2

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0600431	Tonsil; germinal center cells[≥Low]	Tonsil; germinal center cells[≥Low]	110	4.209217e-10	2
HPA	HPA:0600432	Tonsil; germinal center cells[≥Medium]	Tonsil; germinal center cells[≥Medium]	87	4.938593e-09	2
HPA	HPA:0301371	Lung; alveolar cells type II[≥Low]	Lung; alveolar cells type II[≥Low]	49	5.330455e-09	2
HPA	HPA:0310000	Lymph node	Lymph node	113	9.490521e-09	2
HPA	HPA:0301372	Lung; alveolar cells type II[≥Medium]	Lung; alveolar cells type II[≥Medium]	43	9.534193e-09	2
HPA	HPA:0300000	Lung	Lung	120	1.852936e-08	2
HPA	HPA:0630000	Cervix	Cervix	116	2.292183e-08	2
HPA	HPA:0380000	Placenta	Placenta	121	2.414507e-08	2
HPA	HPA:0040081	Bone marrow; hematopoietic cells[≥Low]	Bone marrow; hematopoietic cells[≥Low]	111	9.720774e-08	2
HPA	HPA:0040000	Bone marrow	Bone marrow	111	9.720774e-08	2
HPA	HPA:0430000	Seminal vesicle	Seminal vesicle	114	1.109175e-07	2
HPA	HPA:0430051	Seminal vesicle; glandular cells[≥Low]	Seminal vesicle; glandular cells[≥Low]	114	1.109175e-07	2
HPA	HPA:0600000	Tonsil	Tonsil	122	1.683503e-07	2
HPA	HPA:0310441	Lymph node; non-germinal center cells[≥Low]	Lymph node; non-germinal center cells[≥Low]	106	2.290909e-07	2
HPA	HPA:0300411	Lung; macrophages[≥Low]	Lung; macrophages[≥Low]	113	2.389511e-07	2
HPA	HPA:0030000	Appendix	Appendix	122	2.912137e-07	2
HPA	HPA:0590000	Thyroid gland	Thyroid gland	116	2.951282e-07	2
HPA	HPA:0590051	Thyroid gland; glandular cells[≥Low]	Thyroid gland; glandular cells[≥Low]	116	2.951282e-07	2
HPA	HPA:0210000	Fallopian tube	Fallopian tube	119	2.958798e-07	2
HPA	HPA:0170000	Endometrium 2	Endometrium 2	114	3.466992e-07	2
HPA	HPA:0020052	Adrenal gland; glandular cells[≥Medium]	Adrenal gland; glandular cells[≥Medium]	105	4.153878e-07	2
HPA	HPA:0170051	Endometrium 2; glandular cells[≥Low]	Endometrium 2; glandular cells[≥Low]	112	4.408365e-07	2
HPA	HPA:0020051	Adrenal gland; glandular cells[≥Low]	Adrenal gland; glandular cells[≥Low]	118	6.177931e-07	2
HPA	HPA:0600221	Tonsil; squamous epithelial cells[≥Low]	Tonsil; squamous epithelial cells[≥Low]	111	6.289370e-07	2
HPA	HPA:0020000	Adrenal gland	Adrenal gland	118	6.733121e-07	2
HPA	HPA:0430052	Seminal vesicle; glandular cells[≥Medium]	Seminal vesicle; glandular cells[≥Medium]	96	7.881188e-07	2
HPA	HPA:0290000	Liver	Liver	107	1.158012e-06	2
HPA	HPA:0160051	Endometrium 1; glandular cells[≥Low]	Endometrium 1; glandular cells[≥Low]	112	1.377094e-06	2
HPA	HPA:0600441	Tonsil; non-germinal center cells[≥Low]	Tonsil; non-germinal center cells[≥Low]	105	1.580681e-06	2
HPA	HPA:0050051	Breast; glandular cells[≥Low]	Breast; glandular cells[≥Low]	111	4.314912e-06	2
HPA	HPA:0220052	Gallbladder; glandular cells[≥Medium]	Gallbladder; glandular cells[≥Medium]	109	4.629477e-06	2
HPA	HPA:0470000	Skin 2	Skin 2	113	4.946542e-06	2
HPA	HPA:0471391	Skin 2; cells in basal layer[≥Low]	Skin 2; cells in basal layer[≥Low]	33	5.275728e-06	2
HPA	HPA:0310431	Lymph node; germinal center cells[≥Low]	Lymph node; germinal center cells[≥Low]	92	6.303261e-06	2
HPA	HPA:0550051	Stomach 2; glandular cells[≥Low]	Stomach 2; glandular cells[≥Low]	118	6.405175e-06	2
HPA	HPA:0550000	Stomach 2	Stomach 2	118	6.405175e-06	2
HPA	HPA:0160000	Endometrium 1	Endometrium 1	113	6.451551e-06	2
HPA	HPA:0630051	Cervix; glandular cells[≥Low]	Cervix; glandular cells[≥Low]	99	7.332081e-06	2
HPA	HPA:0270000	Kidney	Kidney	123	8.344667e-06	2
HPA	HPA:0190000	Esophagus	Esophagus	109	9.741435e-06	2
HPA	HPA:0190221	Esophagus; squamous epithelial cells[≥Low]	Esophagus; squamous epithelial cells[≥Low]	109	9.741435e-06	2
HPA	HPA:0220000	Gallbladder	Gallbladder	118	1.157364e-05	2
HPA	HPA:0220051	Gallbladder; glandular cells[≥Low]	Gallbladder; glandular cells[≥Low]	118	1.157364e-05	2
HPA	HPA:0540051	Stomach 1; glandular cells[≥Low]	Stomach 1; glandular cells[≥Low]	118	1.211907e-05	2
HPA	HPA:0540000	Stomach 1	Stomach 1	118	1.211907e-05	2
HPA	HPA:0471471	Skin 2; lymphocytes[≥Low]	Skin 2; lymphocytes[≥Low]	29	1.502721e-05	2
HPA	HPA:0170052	Endometrium 2; glandular cells[≥Medium]	Endometrium 2; glandular cells[≥Medium]	89	1.789325e-05	2
HPA	HPA:0610832	Urinary bladder; urothelial cells[≥Medium]	Urinary bladder; urothelial cells[≥Medium]	101	1.806392e-05	2
HPA	HPA:0330000	Oral mucosa	Oral mucosa	104	2.152213e-05	2
HPA	HPA:0330221	Oral mucosa; squamous epithelial cells[≥Low]	Oral mucosa; squamous epithelial cells[≥Low]	104	2.152213e-05	2
HPA	HPA:0530711	Spleen; cells in red pulp[≥Low]	Spleen; cells in red pulp[≥Low]	94	2.213640e-05	2
HPA	HPA:0050000	Breast	Breast	113	2.706790e-05	2
HPA	HPA:0530000	Spleen	Spleen	100	2.715459e-05	2
HPA	HPA:0390051	Prostate; glandular cells[≥Low]	Prostate; glandular cells[≥Low]	108	2.847805e-05	2
HPA	HPA:0390000	Prostate	Prostate	108	2.847805e-05	2
HPA	HPA:0350000	Pancreas	Pancreas	115	2.919842e-05	2
HPA	HPA:0610000	Urinary bladder	Urinary bladder	114	3.012002e-05	2
HPA	HPA:0610831	Urinary bladder; urothelial cells[≥Low]	Urinary bladder; urothelial cells[≥Low]	114	3.012002e-05	2
HPA	HPA:0030072	Appendix; lymphoid tissue[≥Medium]	Appendix; lymphoid tissue[≥Medium]	64	3.323170e-05	2
HPA	HPA:0600222	Tonsil; squamous epithelial cells[≥Medium]	Tonsil; squamous epithelial cells[≥Medium]	89	3.352927e-05	2
HPA	HPA:0301362	Lung; alveolar cells type I[≥Medium]	Lung; alveolar cells type I[≥Medium]	30	3.728114e-05	2
HPA	HPA:0290401	Liver; hepatocytes[≥Low]	Liver; hepatocytes[≥Low]	98	3.785786e-05	2
HPA	HPA:0310432	Lymph node; germinal center cells[≥Medium]	Lymph node; germinal center cells[≥Medium]	68	4.311190e-05	2
HPA	HPA:0180000	Epididymis	Epididymis	114	4.477148e-05	2
HPA	HPA:0180051	Epididymis; glandular cells[≥Low]	Epididymis; glandular cells[≥Low]	114	4.477148e-05	2
HPA	HPA:0390052	Prostate; glandular cells[≥Medium]	Prostate; glandular cells[≥Medium]	87	4.841377e-05	2
HPA	HPA:0460000	Skin 1	Skin 1	113	5.115508e-05	2
HPA	HPA:0350471	Pancreas; exocrine glandular cells[≥Low]	Pancreas; exocrine glandular cells[≥Low]	110	5.808152e-05	2
HPA	HPA:0301373	Lung; alveolar cells type II[High]	Lung; alveolar cells type II[High]	25	6.665014e-05	2
HPA	HPA:0470671	Skin 2; melanocytes[≥Low]	Skin 2; melanocytes[≥Low]	26	9.542648e-05	2
HPA	HPA:0301361	Lung; alveolar cells type I[≥Low]	Lung; alveolar cells type I[≥Low]	33	1.051735e-04	2
HPA	HPA:0400000	Rectum	Rectum	119	1.085271e-04	2
HPA	HPA:0190222	Esophagus; squamous epithelial cells[≥Medium]	Esophagus; squamous epithelial cells[≥Medium]	89	1.152050e-04	2
HPA	HPA:0060000	Bronchus	Bronchus	114	1.301905e-04	2
HPA	HPA:0470672	Skin 2; melanocytes[≥Medium]	Skin 2; melanocytes[≥Medium]	24	1.331506e-04	2
HPA	HPA:0030071	Appendix; lymphoid tissue[≥Low]	Appendix; lymphoid tissue[≥Low]	85	1.364282e-04	2
HPA	HPA:0471461	Skin 2; langerhans cells[≥Low]	Skin 2; langerhans cells[≥Low]	27	1.424607e-04	2
HPA	HPA:0340000	Ovary	Ovary	93	1.615977e-04	2
HPA	HPA:0550052	Stomach 2; glandular cells[≥Medium]	Stomach 2; glandular cells[≥Medium]	102	2.122673e-04	2
HPA	HPA:0510000	Soft tissue 2	Soft tissue 2	90	2.229693e-04	2
HPA	HPA:0471441	Skin 2; fibrohistiocytic cells[≥Low]	Skin 2; fibrohistiocytic cells[≥Low]	31	2.398495e-04	2
HPA	HPA:0471462	Skin 2; langerhans cells[≥Medium]	Skin 2; langerhans cells[≥Medium]	24	2.448254e-04	2
HPA	HPA:0340461	Ovary; ovarian stroma cells[≥Low]	Ovary; ovarian stroma cells[≥Low]	75	2.664045e-04	2
HPA	HPA:0530721	Spleen; cells in white pulp[≥Low]	Spleen; cells in white pulp[≥Low]	79	4.011467e-04	2
HPA	HPA:0380511	Placenta; decidual cells[≥Low]	Placenta; decidual cells[≥Low]	85	4.193973e-04	2
HPA	HPA:0100000	Cerebral cortex	Cerebral cortex	119	4.428243e-04	2
HPA	HPA:0130000	Colon	Colon	121	4.494543e-04	2
HPA	HPA:0150000	Duodenum	Duodenum	117	5.484254e-04	2
HPA	HPA:0430053	Seminal vesicle; glandular cells[High]	Seminal vesicle; glandular cells[High]	38	6.112120e-04	2
HPA	HPA:0300201	Lung; endothelial cells[≥Low]	Lung; endothelial cells[≥Low]	26	6.192892e-04	2
HPA	HPA:0530722	Spleen; cells in white pulp[≥Medium]	Spleen; cells in white pulp[≥Medium]	57	6.228048e-04	2
HPA	HPA:0160052	Endometrium 1; glandular cells[≥Medium]	Endometrium 1; glandular cells[≥Medium]	88	7.685026e-04	2
HPA	HPA:0180052	Epididymis; glandular cells[≥Medium]	Epididymis; glandular cells[≥Medium]	94	8.555343e-04	2
HPA	HPA:0461461	Skin 1; langerhans cells[≥Low]	Skin 1; langerhans cells[≥Low]	24	9.736282e-04	2
HPA	HPA:0080131	Caudate; neuronal cells[≥Low]	Caudate; neuronal cells[≥Low]	99	1.041368e-03	2
HPA	HPA:0540052	Stomach 1; glandular cells[≥Medium]	Stomach 1; glandular cells[≥Medium]	101	1.058171e-03	2
HPA	HPA:0630052	Cervix; glandular cells[≥Medium]	Cervix; glandular cells[≥Medium]	74	1.063500e-03	2
HPA	HPA:0250000	Hippocampus	Hippocampus	106	1.064406e-03	2
HPA	HPA:0050052	Breast; glandular cells[≥Medium]	Breast; glandular cells[≥Medium]	87	1.098210e-03	2
HPA	HPA:0630221	Cervix; squamous epithelial cells[≥Low]	Cervix; squamous epithelial cells[≥Low]	91	1.142505e-03	2
HPA	HPA:0461391	Skin 1; cells in basal layer[≥Low]	Skin 1; cells in basal layer[≥Low]	27	1.191469e-03	2
HPA	HPA:0470201	Skin 2; endothelial cells[≥Low]	Skin 2; endothelial cells[≥Low]	27	1.381573e-03	2
HPA	HPA:0600433	Tonsil; germinal center cells[High]	Tonsil; germinal center cells[High]	33	1.528966e-03	2
HPA	HPA:0460201	Skin 1; endothelial cells[≥Low]	Skin 1; endothelial cells[≥Low]	26	1.583609e-03	2
HPA	HPA:0250131	Hippocampus; neuronal cells[≥Low]	Hippocampus; neuronal cells[≥Low]	99	1.877555e-03	2
HPA	HPA:0471473	Skin 2; lymphocytes[High]	Skin 2; lymphocytes[High]	18	2.072903e-03	2
HPA	HPA:0471472	Skin 2; lymphocytes[≥Medium]	Skin 2; lymphocytes[≥Medium]	22	2.091397e-03	2
HPA	HPA:0300202	Lung; endothelial cells[≥Medium]	Lung; endothelial cells[≥Medium]	22	2.363501e-03	2
HPA	HPA:0351181	Pancreas; pancreatic endocrine cells[≥Low]	Pancreas; pancreatic endocrine cells[≥Low]	92	2.457922e-03	2
HPA	HPA:0360000	Parathyroid gland	Parathyroid gland	95	2.552218e-03	2
HPA	HPA:0360051	Parathyroid gland; glandular cells[≥Low]	Parathyroid gland; glandular cells[≥Low]	95	2.552218e-03	2
HPA	HPA:0620000	Vagina	Vagina	96	2.991134e-03	2
HPA	HPA:0620221	Vagina; squamous epithelial cells[≥Low]	Vagina; squamous epithelial cells[≥Low]	96	2.991134e-03	2
HPA	HPA:0461471	Skin 1; lymphocytes[≥Low]	Skin 1; lymphocytes[≥Low]	23	3.005363e-03	2
HPA	HPA:0250121	Hippocampus; glial cells[≥Low]	Hippocampus; glial cells[≥Low]	74	3.180016e-03	2
HPA	HPA:0310442	Lymph node; non-germinal center cells[≥Medium]	Lymph node; non-germinal center cells[≥Medium]	72	3.229817e-03	2
HPA	HPA:0100201	Cerebral cortex; endothelial cells[≥Low]	Cerebral cortex; endothelial cells[≥Low]	80	3.262980e-03	2
HPA	HPA:0570731	Testis; Leydig cells[≥Low]	Testis; Leydig cells[≥Low]	108	3.373482e-03	2
HPA	HPA:0180053	Epididymis; glandular cells[High]	Epididymis; glandular cells[High]	42	3.683154e-03	2
HPA	HPA:0570000	Testis	Testis	125	3.688849e-03	2
HPA	HPA:0480000	Small intestine	Small intestine	115	3.779806e-03	2
HPA	HPA:0080000	Caudate	Caudate	106	3.829489e-03	2
HPA	HPA:0461441	Skin 1; fibrohistiocytic cells[≥Low]	Skin 1; fibrohistiocytic cells[≥Low]	26	3.936397e-03	2
HPA	HPA:0210053	Fallopian tube; glandular cells[High]	Fallopian tube; glandular cells[High]	39	4.024321e-03	2
HPA	HPA:0471442	Skin 2; fibrohistiocytic cells[≥Medium]	Skin 2; fibrohistiocytic cells[≥Medium]	25	4.119894e-03	2
HPA	HPA:0040082	Bone marrow; hematopoietic cells[≥Medium]	Bone marrow; hematopoietic cells[≥Medium]	75	4.488857e-03	2
HPA	HPA:0420051	Salivary gland; glandular cells[≥Low]	Salivary gland; glandular cells[≥Low]	105	5.150520e-03	2
HPA	HPA:0420000	Salivary gland	Salivary gland	105	5.150520e-03	2
HPA	HPA:0090000	Cerebellum	Cerebellum	108	5.241088e-03	2
HPA	HPA:0320000	Nasopharynx	Nasopharynx	108	5.484611e-03	2
HPA	HPA:0470202	Skin 2; endothelial cells[≥Medium]	Skin 2; endothelial cells[≥Medium]	21	5.503808e-03	2
HPA	HPA:0600442	Tonsil; non-germinal center cells[≥Medium]	Tonsil; non-germinal center cells[≥Medium]	74	5.524049e-03	2
HPA	HPA:0151292	Duodenum; endocrine cells[≥Medium]	Duodenum; endocrine cells[≥Medium]	17	6.477417e-03	2
HPA	HPA:0090181	Cerebellum; cells in granular layer[≥Low]	Cerebellum; cells in granular layer[≥Low]	78	6.616595e-03	2
HPA	HPA:0461442	Skin 1; fibrohistiocytic cells[≥Medium]	Skin 1; fibrohistiocytic cells[≥Medium]	22	7.003317e-03	2
HPA	HPA:0210051	Fallopian tube; glandular cells[≥Low]	Fallopian tube; glandular cells[≥Low]	92	7.308145e-03	2
HPA	HPA:0471392	Skin 2; cells in basal layer[≥Medium]	Skin 2; cells in basal layer[≥Medium]	23	7.523984e-03	2
HPA	HPA:0090161	Cerebellum; Purkinje cells[≥Low]	Cerebellum; Purkinje cells[≥Low]	90	7.634157e-03	2
HPA	HPA:0220053	Gallbladder; glandular cells[High]	Gallbladder; glandular cells[High]	56	7.927595e-03	2
HPA	HPA:0610833	Urinary bladder; urothelial cells[High]	Urinary bladder; urothelial cells[High]	44	8.270036e-03	2
HPA	HPA:0151342	Duodenum; glands of Brunner[≥Medium]	Duodenum; glands of Brunner[≥Medium]	11	8.359866e-03	2
HPA	HPA:0471411	Skin 2; cells in spinous layer[≥Low]	Skin 2; cells in spinous layer[≥Low]	25	8.752889e-03	2
HPA	HPA:0030052	Appendix; glandular cells[≥Medium]	Appendix; glandular cells[≥Medium]	89	8.769165e-03	2
HPA	HPA:0060102	Bronchus; respiratory epithelial cells[≥Medium]	Bronchus; respiratory epithelial cells[≥Medium]	82	9.241456e-03	2
HPA	HPA:0590052	Thyroid gland; glandular cells[≥Medium]	Thyroid gland; glandular cells[≥Medium]	90	9.592644e-03	2
HPA	HPA:0100121	Cerebral cortex; glial cells[≥Low]	Cerebral cortex; glial cells[≥Low]	82	1.046701e-02	2
HPA	HPA:0160053	Endometrium 1; glandular cells[High]	Endometrium 1; glandular cells[High]	35	1.058335e-02	2
HPA	HPA:0291161	Liver; cholangiocytes[≥Low]	Liver; cholangiocytes[≥Low]	70	1.149153e-02	2
HPA	HPA:0570732	Testis; Leydig cells[≥Medium]	Testis; Leydig cells[≥Medium]	87	1.254837e-02	2
HPA	HPA:0151302	Duodenum; enterocytes[≥Medium]	Duodenum; enterocytes[≥Medium]	16	1.330056e-02	2
HPA	HPA:0381191	Placenta; cytotrophoblasts[≥Low]	Placenta; cytotrophoblasts[≥Low]	17	1.391705e-02	2
HPA	HPA:0050091	Breast; myoepithelial cells[≥Low]	Breast; myoepithelial cells[≥Low]	90	1.621072e-02	2
HPA	HPA:0481302	Small intestine; enterocytes[≥Medium]	Small intestine; enterocytes[≥Medium]	16	1.950807e-02	2
HPA	HPA:0460202	Skin 1; endothelial cells[≥Medium]	Skin 1; endothelial cells[≥Medium]	19	2.081526e-02	2
HPA	HPA:0151291	Duodenum; endocrine cells[≥Low]	Duodenum; endocrine cells[≥Low]	17	2.095105e-02	2
HPA	HPA:0210052	Fallopian tube; glandular cells[≥Medium]	Fallopian tube; glandular cells[≥Medium]	78	2.148905e-02	2
HPA	HPA:0390053	Prostate; glandular cells[High]	Prostate; glandular cells[High]	32	2.149454e-02	2
HPA	HPA:0151341	Duodenum; glands of Brunner[≥Low]	Duodenum; glands of Brunner[≥Low]	12	2.177224e-02	2
HPA	HPA:0570801	Testis; sertoli cells[≥Low]	Testis; sertoli cells[≥Low]	50	2.230666e-02	2
HPA	HPA:0271111	Kidney; bowman's capsule[≥Low]	Kidney; bowman's capsule[≥Low]	12	2.422966e-02	2
HPA	HPA:0401292	Rectum; endocrine cells[≥Medium]	Rectum; endocrine cells[≥Medium]	15	2.569960e-02	2
HPA	HPA:0090191	Cerebellum; cells in molecular layer[≥Low]	Cerebellum; cells in molecular layer[≥Low]	75	2.643209e-02	2
HPA	HPA:0301363	Lung; alveolar cells type I[High]	Lung; alveolar cells type I[High]	17	2.951121e-02	2
HPA	HPA:0481292	Small intestine; endocrine cells[≥Medium]	Small intestine; endocrine cells[≥Medium]	16	3.115008e-02	2
HPA	HPA:0300412	Lung; macrophages[≥Medium]	Lung; macrophages[≥Medium]	80	3.339020e-02	2
HPA	HPA:0050092	Breast; myoepithelial cells[≥Medium]	Breast; myoepithelial cells[≥Medium]	66	3.506696e-02	2
HPA	HPA:0350473	Pancreas; exocrine glandular cells[High]	Pancreas; exocrine glandular cells[High]	41	3.709412e-02	2
HPA	HPA:0060103	Bronchus; respiratory epithelial cells[High]	Bronchus; respiratory epithelial cells[High]	39	3.883720e-02	2
HPA	HPA:0461472	Skin 1; lymphocytes[≥Medium]	Skin 1; lymphocytes[≥Medium]	18	4.365361e-02	2
HPA	HPA:0471412	Skin 2; cells in spinous layer[≥Medium]	Skin 2; cells in spinous layer[≥Medium]	20	4.554392e-02	2
HPA	HPA:0381202	Placenta; hofbauer cells[≥Medium]	Placenta; hofbauer cells[≥Medium]	14	4.946528e-02	2
HPA	HPA:0150893	Duodenum; goblet cells[High]	Duodenum; goblet cells[High]	10	4.996365e-02	2

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M00803	Factor: E2F; motif: GGCGSG	Factor: E2F; motif: GGCGSG	144	0.000002	2
TF	TF:M08526_1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	154	0.000002	2
TF	TF:M08205	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT	151	0.000003	2
TF	TF:M10438_1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	153	0.000004	2
TF	TF:M09894_1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	147	0.000015	2
TF	TF:M12599_1	Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1	Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1	156	0.000022	2
TF	TF:M08205_1	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1	122	0.000045	2
TF	TF:M12173	Factor: GKLF; motif: NNCCMCRCCCN	Factor: GKLF; motif: NNCCMCRCCCN	118	0.000081	2
TF	TF:M00736	Factor: E2F-1:DP-1; motif: TTTCSCGC	Factor: E2F-1:DP-1; motif: TTTCSCGC	120	0.000158	2
TF	TF:M08313_1	Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1	Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1	114	0.000233	2
TF	TF:M09892	Factor: E2F-1; motif: NNNNGGCGGGAARN	Factor: E2F-1; motif: NNNNGGCGGGAARN	142	0.000269	2
TF	TF:M09894	Factor: E2F-4; motif: SNGGGCGGGAANN	Factor: E2F-4; motif: SNGGGCGGGAANN	157	0.000292	2
TF	TF:M02090	Factor: E2F-4; motif: GCGGGAAANA	Factor: E2F-4; motif: GCGGGAAANA	131	0.000349	2
TF	TF:M11531	Factor: E2F-2; motif: GCGCGCGCGYW	Factor: E2F-2; motif: GCGCGCGCGYW	140	0.000376	2
TF	TF:M07206_1	Factor: E2F-1; motif: NGGGCGGGARV; match class: 1	Factor: E2F-1; motif: NGGGCGGGARV; match class: 1	123	0.000384	2
TF	TF:M02065_1	Factor: ER81; motif: RCCGGAARYN; match class: 1	Factor: ER81; motif: RCCGGAARYN; match class: 1	91	0.000384	2
TF	TF:M00736_1	Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1	Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1	68	0.000921	2
TF	TF:M01783	Factor: SP2; motif: GGGCGGGAC	Factor: SP2; motif: GGGCGGGAC	108	0.001225	2
TF	TF:M00333	Factor: ZF5; motif: NRNGNGCGCGCWN	Factor: ZF5; motif: NRNGNGCGCGCWN	150	0.001229	2
TF	TF:M07206	Factor: E2F-1; motif: NGGGCGGGARV	Factor: E2F-1; motif: NGGGCGGGARV	147	0.001340	2
TF	TF:M11434	Factor: Elk-1; motif: NRSCGGAAGNN	Factor: Elk-1; motif: NRSCGGAAGNN	100	0.001467	2
TF	TF:M10438	Factor: ZF5; motif: GGSGCGCGS	Factor: ZF5; motif: GGSGCGCGS	156	0.001482	2
TF	TF:M08525	Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM	Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM	160	0.001486	2
TF	TF:M12151	Factor: Sp1; motif: NWRGCCMCGCCCMCN	Factor: Sp1; motif: NWRGCCMCGCCCMCN	88	0.001629	2
TF	TF:M00716_1	Factor: ZF5; motif: GSGCGCGR; match class: 1	Factor: ZF5; motif: GSGCGCGR; match class: 1	144	0.001652	2
TF	TF:M00428	Factor: E2F-1; motif: NKTSSCGC	Factor: E2F-1; motif: NKTSSCGC	106	0.001884	2
TF	TF:M12600	Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN	Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN	103	0.002254	2
TF	TF:M08913_1	Factor: FLI-1; motif: NAYTTCCGGT; match class: 1	Factor: FLI-1; motif: NAYTTCCGGT; match class: 1	50	0.002428	2
TF	TF:M11529_1	Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1	Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1	146	0.002539	2
TF	TF:M04826_1	Factor: p300; motif: ACNTCCG; match class: 1	Factor: p300; motif: ACNTCCG; match class: 1	150	0.003323	2
TF	TF:M01660	Factor: GABP-alpha; motif: CTTCCK	Factor: GABP-alpha; motif: CTTCCK	121	0.006140	2
TF	TF:M08526	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN	158	0.006488	2
TF	TF:M12597	Factor: E2F1; motif: GSGCGGGAAN	Factor: E2F1; motif: GSGCGGGAAN	142	0.006921	2
TF	TF:M00695	Factor: ETF; motif: GVGGMGG	Factor: ETF; motif: GVGGMGG	116	0.008228	2
TF	TF:M11396_1	Factor: Erg; motif: NACCGGAARTN; match class: 1	Factor: Erg; motif: NACCGGAARTN; match class: 1	68	0.008463	2
TF	TF:M09892_1	Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1	Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1	106	0.008797	2
TF	TF:M00716	Factor: ZF5; motif: GSGCGCGR	Factor: ZF5; motif: GSGCGCGR	154	0.009697	2
TF	TF:M11529	Factor: E2F-2; motif: GCGCGCGCNCS	Factor: E2F-2; motif: GCGCGCGCNCS	155	0.010063	2
TF	TF:M04823	Factor: E2F-4; motif: NNTTCCCGCCNN	Factor: E2F-4; motif: NNTTCCCGCCNN	133	0.010159	2
TF	TF:M11435	Factor: Elk-1; motif: NNCCGGAAGTN	Factor: Elk-1; motif: NNCCGGAAGTN	125	0.010408	2
TF	TF:M08759	Factor: c-Ets-2; motif: NCCGGAAGTG	Factor: c-Ets-2; motif: NCCGGAAGTG	98	0.010641	2
TF	TF:M11535	Factor: E2F-4; motif: TTTTGGCGCCAWWN	Factor: E2F-4; motif: TTTTGGCGCCAWWN	119	0.010827	2
TF	TF:M02071_1	Factor: ETV7; motif: NCCGGAANNN; match class: 1	Factor: ETV7; motif: NCCGGAANNN; match class: 1	63	0.011608	2
TF	TF:M11530	Factor: E2F-2; motif: NWTTTGGCGCCAWWNN	Factor: E2F-2; motif: NWTTTGGCGCCAWWNN	145	0.012008	2
TF	TF:M03567	Factor: Sp2; motif: NYSGCCCCGCCCCCY	Factor: Sp2; motif: NYSGCCCCGCCCCCY	93	0.013769	2
TF	TF:M00196	Factor: Sp1; motif: NGGGGGCGGGGYN	Factor: Sp1; motif: NGGGGGCGGGGYN	114	0.014362	2
TF	TF:M03971	Factor: ELK1; motif: NACTTCCGSCGGAAGYN	Factor: ELK1; motif: NACTTCCGSCGGAAGYN	121	0.018359	2
TF	TF:M07380	Factor: E2F-4; motif: NTTTCSCGCC	Factor: E2F-4; motif: NTTTCSCGCC	134	0.018617	2
TF	TF:M11396	Factor: Erg; motif: NACCGGAARTN	Factor: Erg; motif: NACCGGAARTN	117	0.020214	2
TF	TF:M12186	Factor: BTEB4; motif: NCCACGCCCM	Factor: BTEB4; motif: NCCACGCCCM	104	0.022363	2
TF	TF:M10071	Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG	Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG	99	0.025031	2
TF	TF:M11531_1	Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1	Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1	129	0.025375	2
TF	TF:M09606	Factor: nerf; motif: NRRNSCGGAAGNRNNNN	Factor: nerf; motif: NRRNSCGGAAGNRNNNN	79	0.027954	2
TF	TF:M00431	Factor: E2F-1; motif: TTTSGCGS	Factor: E2F-1; motif: TTTSGCGS	88	0.029160	2
TF	TF:M03807	Factor: SP2; motif: GNNGGGGGCGGGGSN	Factor: SP2; motif: GNNGGGGGCGGGGSN	98	0.031809	2
TF	TF:M12666	Factor: SP1; motif: GGCCCCGCCCCCN	Factor: SP1; motif: GGCCCCGCCCCCN	100	0.032542	2
TF	TF:M02090_1	Factor: E2F-4; motif: GCGGGAAANA; match class: 1	Factor: E2F-4; motif: GCGGGAAANA; match class: 1	80	0.033542	2
TF	TF:M00025_1	Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1	Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1	61	0.036196	2
TF	TF:M07380_1	Factor: E2F-4; motif: NTTTCSCGCC; match class: 1	Factor: E2F-4; motif: NTTTCSCGCC; match class: 1	94	0.037918	2
TF	TF:M11424	Factor: Erm; motif: NNSCGGAWGYN	Factor: Erm; motif: NNSCGGAWGYN	95	0.038053	2
TF	TF:M04714	Factor: Elf-1; motif: ACTTCCGGG	Factor: Elf-1; motif: ACTTCCGGG	92	0.038212	2
TF	TF:M08525_1	Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1	Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1	148	0.043256	2
TF	TF:M02071	Factor: ETV7; motif: NCCGGAANNN	Factor: ETV7; motif: NCCGGAANNN	111	0.043416	2
TF	TF:M02065	Factor: ER81; motif: RCCGGAARYN	Factor: ER81; motif: RCCGGAARYN	131	0.043882	2
TF	TF:M07415	Factor: Elf-1; motif: AWCCCGGAAGTN	Factor: Elf-1; motif: AWCCCGGAAGTN	93	0.045367	2
TF	TF:M03971_1	Factor: ELK1; motif: NACTTCCGSCGGAAGYN; match class: 1	Factor: ELK1; motif: NACTTCCGSCGGAAGYN; match class: 1	86	0.046682	2
TF	TF:M11882	Factor: pax-6; motif: NYACGCNYSANYGMNCN	Factor: pax-6; motif: NYACGCNYSANYGMNCN	149	0.047412	2
TF	TF:M07084	Factor: E2F-4; motif: NGGCGGGAARN	Factor: E2F-4; motif: NGGCGGGAARN	117	0.047482	2
TF	TF:M13135	Factor: SP4; motif: GGCCCCGCCCCCN	Factor: SP4; motif: GGCCCCGCCCCCN	72	0.049228	2

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04141	Protein processing in endoplasmic reticulum	Protein processing in endoplasmic reticulum	13	0.000004	2
KEGG	KEGG:01100	Metabolic pathways	Metabolic pathways	32	0.025482	2
KEGG	KEGG:01200	Carbon metabolism	Carbon metabolism	7	0.028711	2
KEGG	KEGG:03460	Fanconi anemia pathway	Fanconi anemia pathway	5	0.031205	2

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-let-7b-5p	hsa-let-7b-5p	hsa-let-7b-5p	33	0.000005	2
MIRNA	MIRNA:hsa-mir-92a-3p	hsa-mir-92a-3p	hsa-mir-92a-3p	30	0.002789	2
MIRNA	MIRNA:hsa-mir-615-3p	hsa-mir-615-3p	hsa-mir-615-3p	24	0.005233	2
MIRNA	MIRNA:hsa-mir-193b-3p	hsa-mir-193b-3p	hsa-mir-193b-3p	22	0.005242	2
MIRNA	MIRNA:hsa-mir-30a-5p	hsa-mir-30a-5p	hsa-mir-30a-5p	20	0.006808	2
MIRNA	MIRNA:hsa-mir-210-3p	hsa-mir-210-3p	hsa-mir-210-3p	8	0.016136	2
MIRNA	MIRNA:hsa-mir-34a-5p	hsa-mir-34a-5p	hsa-mir-34a-5p	17	0.017789	2
MIRNA	MIRNA:hsa-mir-16-5p	hsa-mir-16-5p	hsa-mir-16-5p	30	0.033821	2

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5394	UDP derived sugars synthesis in fibroblasts	UDP derived sugars synthesis in fibroblasts	4	0.000833	2
WP	WP:WP4595	Urea cycle and associated pathways	Urea cycle and associated pathways	5	0.001045	2
WP	WP:WP5355	Metabolic epileptic disorders	Metabolic epileptic disorders	8	0.001378	2
WP	WP:WP534	Glycolysis and gluconeogenesis	Glycolysis and gluconeogenesis	6	0.001787	2
WP	WP:WP4290	Metabolic reprogramming in colon cancer	Metabolic reprogramming in colon cancer	5	0.017796	2
WP	WP:WP5049	Glycolysis in senescence	Glycolysis in senescence	3	0.037789	2
WP	WP:WP3875	ATR signaling	ATR signaling	3	0.037789	2

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	6	0.001334	2
REAC	REAC:R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	PCNA-Dependent Long Patch Base Excision Repair	5	0.001640	2
REAC	REAC:R-HSA-3371511	HSF1 activation	HSF1 activation	4	0.003688	2
REAC	REAC:R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	5	0.004120	2
REAC	REAC:R-HSA-901042	Calnexin/calreticulin cycle	Calnexin/calreticulin cycle	5	0.005052	2
REAC	REAC:R-HSA-15869	Metabolism of nucleotides	Metabolism of nucleotides	8	0.005315	2
REAC	REAC:R-HSA-69166	Removal of the Flap Intermediate	Removal of the Flap Intermediate	4	0.007318	2
REAC	REAC:R-HSA-69183	Processive synthesis on the lagging strand	Processive synthesis on the lagging strand	4	0.009886	2
REAC	REAC:R-HSA-1430728	Metabolism	Metabolism	45	0.014490	2
REAC	REAC:R-HSA-174437	Removal of the Flap Intermediate from the C-strand	Removal of the Flap Intermediate from the C-strand	4	0.016916	2
REAC	REAC:R-HSA-73933	Resolution of Abasic Sites (AP sites)	Resolution of Abasic Sites (AP sites)	5	0.026277	2
REAC	REAC:R-HSA-110320	Translesion Synthesis by POLH	Translesion Synthesis by POLH	4	0.027037	2
REAC	REAC:R-HSA-174414	Processive synthesis on the C-strand of the telomere	Processive synthesis on the C-strand of the telomere	4	0.027037	2
REAC	REAC:R-HSA-446203	Asparagine N-linked glycosylation	Asparagine N-linked glycosylation	13	0.031428	2
REAC	REAC:R-HSA-69186	Lagging Strand Synthesis	Lagging Strand Synthesis	4	0.033481	2
REAC	REAC:R-HSA-6783310	Fanconi Anemia Pathway	Fanconi Anemia Pathway	5	0.038983	2

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:5229	RPA complex	RPA complex	2	0.049771	2

Community 3

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	42	1.260554e-50	3
GO:BP	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	58	1.913893e-41	3
GO:BP	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	27	9.898350e-18	3
GO:BP	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	123	7.722337e-17	3
GO:BP	GO:0009059	macromolecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	123	6.275410e-15	3
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	83	3.039169e-14	3
GO:BP	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	136	6.106102e-14	3
GO:BP	GO:0051253	negative regulation of RNA metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	42	2.637441e-12	3
GO:BP	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]	135	4.727796e-12	3
GO:BP	GO:1903311	regulation of mRNA metabolic process	"Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	21	2.322926e-11	3
GO:BP	GO:1903312	negative regulation of mRNA metabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	14	3.995692e-11	3
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	"Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	42	5.495122e-11	3
GO:BP	GO:0009058	biosynthetic process	"A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	123	9.211123e-11	3
GO:BP	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	18	1.039904e-10	3
GO:BP	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	22	1.147169e-10	3
GO:BP	GO:2000767	positive regulation of cytoplasmic translation	"Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	8	1.407100e-10	3
GO:BP	GO:0016072	rRNA metabolic process	"The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732]	19	1.568874e-10	3
GO:BP	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	15	1.570004e-10	3
GO:BP	GO:0070934	CRD-mediated mRNA stabilization	"An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303]	7	5.289437e-10	3
GO:BP	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	13	1.201195e-09	3
GO:BP	GO:1902369	negative regulation of RNA catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457]	12	4.939877e-09	3
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	58	7.022580e-09	3
GO:BP	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	79	1.254016e-08	3
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	"Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	53	1.413047e-08	3
GO:BP	GO:0043489	RNA stabilization	"Prevention of degradation of RNA molecules." [GOC:go_curators]	11	1.929644e-08	3
GO:BP	GO:1902373	negative regulation of mRNA catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865]	11	2.227810e-08	3
GO:BP	GO:0008152	metabolic process	"A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	139	2.646229e-08	3
GO:BP	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	59	3.365507e-08	3
GO:BP	GO:0009890	negative regulation of biosynthetic process	"Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	53	3.627115e-08	3
GO:BP	GO:0090304	nucleic acid metabolic process	"Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb]	94	1.128739e-07	3
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	"Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	64	1.270120e-07	3
GO:BP	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	10	1.295030e-07	3
GO:BP	GO:0051252	regulation of RNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	61	1.308660e-07	3
GO:BP	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	16	1.550480e-07	3
GO:BP	GO:1900152	negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]	6	2.078885e-07	3
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	"Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	49	2.615137e-07	3
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	28	3.396429e-07	3
GO:BP	GO:1900151	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]	7	3.650624e-07	3
GO:BP	GO:2000765	regulation of cytoplasmic translation	"Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	8	3.706572e-07	3
GO:BP	GO:0061013	regulation of mRNA catabolic process	"Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]	14	3.761618e-07	3
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	40	4.909684e-07	3
GO:BP	GO:0009891	positive regulation of biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	49	1.013690e-06	3
GO:BP	GO:0141188	nucleic acid catabolic process	"The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators]	17	1.055361e-06	3
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	32	1.253673e-06	3
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	55	1.263300e-06	3
GO:BP	GO:0051254	positive regulation of RNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	39	1.328641e-06	3
GO:BP	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]	9	1.349552e-06	3
GO:BP	GO:0042255	ribosome assembly	"The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]	9	1.349552e-06	3
GO:BP	GO:0043488	regulation of mRNA stability	"Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]	13	1.401857e-06	3
GO:BP	GO:0016070	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	87	1.561331e-06	3
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	"Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	32	1.704625e-06	3
GO:BP	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	16	2.434699e-06	3
GO:BP	GO:0043487	regulation of RNA stability	"Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl]	13	3.080929e-06	3
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	95	3.433181e-06	3
GO:BP	GO:0000956	nuclear-transcribed mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]	11	4.061047e-06	3
GO:BP	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	57	4.176858e-06	3
GO:BP	GO:0140694	membraneless organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081]	18	4.727149e-06	3
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	"Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	40	7.427456e-06	3
GO:BP	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	82	1.002241e-05	3
GO:BP	GO:1903313	positive regulation of mRNA metabolic process	"Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	11	1.534726e-05	3
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	45	2.358633e-05	3
GO:BP	GO:0016071	mRNA metabolic process	"The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	40	3.033748e-05	3
GO:BP	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	46	3.685324e-05	3
GO:BP	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	85	3.735789e-05	3
GO:BP	GO:0061157	mRNA destabilization	"Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh]	9	1.024766e-04	3
GO:BP	GO:0009895	negative regulation of catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	15	1.174619e-04	3
GO:BP	GO:0050779	RNA destabilization	"Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai]	9	1.433177e-04	3
GO:BP	GO:1901796	regulation of signal transduction by p53 class mediator	"Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]	9	1.433177e-04	3
GO:BP	GO:0061014	positive regulation of mRNA catabolic process	"Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]	9	1.555101e-04	3
GO:BP	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	71	1.579777e-04	3
GO:BP	GO:0022613	ribonucleoprotein complex biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah]	35	2.215516e-04	3
GO:BP	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	6	2.649085e-04	3
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	33	2.970108e-04	3
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	33	3.052120e-04	3
GO:BP	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	27	3.458129e-04	3
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	"Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	71	3.572432e-04	3
GO:BP	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	52	4.127026e-04	3
GO:BP	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	73	4.750285e-04	3
GO:BP	GO:0009889	regulation of biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	72	5.033296e-04	3
GO:BP	GO:0032774	RNA biosynthetic process	"The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]	79	5.572285e-04	3
GO:BP	GO:0034655	nucleobase-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	17	7.059845e-04	3
GO:BP	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	32	7.544730e-04	3
GO:BP	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	50	7.675952e-04	3
GO:BP	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	22	8.615042e-04	3
GO:BP	GO:2001141	regulation of RNA biosynthetic process	"Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]	50	9.111702e-04	3
GO:BP	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	75	9.805221e-04	3
GO:BP	GO:0050684	regulation of mRNA processing	"Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]	9	1.069866e-03	3
GO:BP	GO:0141187	nucleic acid biosynthetic process	"The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb]	79	1.174378e-03	3
GO:BP	GO:2001242	regulation of intrinsic apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	10	1.246253e-03	3
GO:BP	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	5	1.250254e-03	3
GO:BP	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	7	1.338604e-03	3
GO:BP	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	23	1.966158e-03	3
GO:BP	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	24	2.142322e-03	3
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	28	2.217436e-03	3
GO:BP	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	48	2.259715e-03	3
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	26	2.397182e-03	3
GO:BP	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	19	2.601315e-03	3
GO:BP	GO:1901798	positive regulation of signal transduction by p53 class mediator	"Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]	5	2.823384e-03	3
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	23	3.509177e-03	3
GO:BP	GO:0006403	RNA localization	"A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]	10	3.776203e-03	3
GO:BP	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	32	4.815350e-03	3
GO:BP	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	21	5.114215e-03	3
GO:BP	GO:0007049	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]	30	5.640207e-03	3
GO:BP	GO:0072331	signal transduction by p53 class mediator	"An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah]	9	5.758562e-03	3
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	79	7.494967e-03	3
GO:BP	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	67	8.670327e-03	3
GO:BP	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	8	9.832491e-03	3
GO:BP	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	22	1.197590e-02	3
GO:BP	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	68	1.493516e-02	3
GO:BP	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	9	1.672892e-02	3
GO:BP	GO:0000380	alternative mRNA splicing, via spliceosome	"The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]	6	2.257012e-02	3
GO:BP	GO:0016032	viral process	"A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah]	13	2.464426e-02	3
GO:BP	GO:0032204	regulation of telomere maintenance	"Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]	7	3.130139e-02	3
GO:BP	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	7	3.130139e-02	3
GO:BP	GO:0051052	regulation of DNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]	14	3.241195e-02	3
GO:BP	GO:0097193	intrinsic apoptotic signaling pathway	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]	11	3.283771e-02	3
GO:BP	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	15	3.625771e-02	3
GO:BP	GO:0032986	protein-DNA complex disassembly	"The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah]	4	3.664508e-02	3
GO:BP	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	19	3.724444e-02	3
GO:BP	GO:0034504	protein localization to nucleus	"A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]	11	3.913631e-02	3
GO:BP	GO:2001233	regulation of apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	12	4.072805e-02	3
GO:BP	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	8	4.784774e-02	3

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	108	2.988184e-50	3
GO:MF	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	125	2.807579e-42	3
GO:MF	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	33	2.272467e-20	3
GO:MF	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	31	5.080024e-20	3
GO:MF	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	37	9.368700e-12	3
GO:MF	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	17	1.610713e-11	3
GO:MF	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	12	9.156120e-11	3
GO:MF	GO:0120545	nucleic acid conformation isomerase activity	"Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-]	15	2.388112e-09	3
GO:MF	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	14	1.450978e-08	3
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	146	2.715342e-08	3
GO:MF	GO:0120543	macromolecular conformation isomerase activity	"Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-]	16	5.622349e-07	3
GO:MF	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	9	4.639405e-06	3
GO:MF	GO:0008186	ATP-dependent activity, acting on RNA	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl]	9	5.862450e-06	3
GO:MF	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	10	1.247359e-05	3
GO:MF	GO:0048027	mRNA 5'-UTR binding	"Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid]	6	1.575473e-05	3
GO:MF	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	45	2.163994e-05	3
GO:MF	GO:0016853	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	17	4.933020e-05	3
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	39	7.713640e-05	3
GO:MF	GO:0140517	protein-RNA adaptor activity	"The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way." [PMID:24470144]	5	1.899602e-04	3
GO:MF	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	19	2.879153e-04	3
GO:MF	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	9	2.951378e-04	3
GO:MF	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	15	4.471995e-04	3
GO:MF	GO:1990247	N6-methyladenosine-containing RNA reader activity	"A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625]	4	1.134127e-03	3
GO:MF	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	27	1.538883e-03	3
GO:MF	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	8	3.639778e-03	3
GO:MF	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	5	4.146029e-03	3
GO:MF	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	17	4.405604e-03	3
GO:MF	GO:0140640	catalytic activity, acting on a nucleic acid	"Catalytic activity that acts to modify a nucleic acid." [GOC:pg]	17	6.515207e-03	3
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	12	7.570365e-03	3
GO:MF	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	153	1.011666e-02	3
GO:MF	GO:0008312	7S RNA binding	"Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]	3	1.102363e-02	3
GO:MF	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	11	1.734168e-02	3
GO:MF	GO:0044389	ubiquitin-like protein ligase binding	"Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]	11	2.923507e-02	3
GO:MF	GO:0017111	ribonucleoside triphosphate phosphatase activity	"Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680]	23	2.944458e-02	3
GO:MF	GO:1990948	ubiquitin ligase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a ubiquitin ligase." [GOC:dph, GOC:vw, PMID:21389117]	3	3.716556e-02	3
GO:MF	GO:0019789	SUMO transferase activity	"Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250]	4	4.266769e-02	3
GO:MF	GO:0160123	structural constituent of nuclear lamina	"The action of a molecule that contributes to the structural integrity of nuclear lamina." [PMID:2824113, PMID:31434876]	2	4.289931e-02	3

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0022626	cytosolic ribosome	"A ribosome located in the cytosol." [GOC:mtg_sensu]	35	5.331712e-46	3
GO:CC	GO:0044391	ribosomal subunit	"Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl]	35	9.729437e-38	3
GO:CC	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	109	5.888256e-30	3
GO:CC	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	96	4.176803e-29	3
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	116	4.782168e-28	3
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	116	4.854718e-28	3
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	114	3.190964e-26	3
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	114	3.190964e-26	3
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	114	3.190964e-26	3
GO:CC	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	38	2.843466e-25	3
GO:CC	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	17	7.052989e-24	3
GO:CC	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	132	2.930880e-22	3
GO:CC	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	17	1.750369e-21	3
GO:CC	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	69	5.757771e-21	3
GO:CC	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	18	1.782608e-20	3
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	153	2.582121e-16	3
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	90	6.055377e-16	3
GO:CC	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	17	1.344883e-15	3
GO:CC	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	52	3.441687e-15	3
GO:CC	GO:0035770	ribonucleoprotein granule	"A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]	22	1.318040e-14	3
GO:CC	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	145	1.932595e-13	3
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	153	3.001532e-13	3
GO:CC	GO:0036464	cytoplasmic ribonucleoprotein granule	"A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]	20	6.242523e-13	3
GO:CC	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	104	8.836185e-13	3
GO:CC	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	14	1.174532e-12	3
GO:CC	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	148	3.223268e-12	3
GO:CC	GO:0030684	preribosome	"Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516]	14	8.858890e-12	3
GO:CC	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	17	4.447302e-11	3
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	154	7.633143e-11	3
GO:CC	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	45	2.696275e-10	3
GO:CC	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	12	6.021871e-10	3
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	21	8.565661e-10	3
GO:CC	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	11	1.156067e-09	3
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	21	1.330333e-09	3
GO:CC	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	29	1.470149e-09	3
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	125	6.564150e-08	3
GO:CC	GO:0070937	CRD-mediated mRNA stability complex	"A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9." [GOC:mah, PMID:19029303]	4	1.172321e-05	3
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	33	1.364466e-05	3
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	41	1.421434e-05	3
GO:CC	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640]	16	1.498591e-05	3
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	23	3.378207e-05	3
GO:CC	GO:0098687	chromosomal region	"Any subdivision of a chromosome along its length." [GOC:dos]	15	5.813673e-05	3
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	36	1.246953e-04	3
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	36	1.753856e-04	3
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	36	1.773684e-04	3
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	36	1.773684e-04	3
GO:CC	GO:0099080	supramolecular complex	"A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]	28	2.882223e-04	3
GO:CC	GO:0000792	heterochromatin	"A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156]	7	6.534929e-04	3
GO:CC	GO:0106002	mCRD-mediated mRNA stability complex	"A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP." [GOC:bhm, PMID:11051545]	3	1.139398e-03	3
GO:CC	GO:0016363	nuclear matrix	"A dynamic, proteinaceous framework within the nucleus of eukaryotic cells, composed of proteins and RNA, that provides structural support for chromatin organization, gene regulation, and nuclear processes." [PMID:15608168, PMID:3058729, PMID:39789220]	8	1.224435e-03	3
GO:CC	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	4	1.346793e-03	3
GO:CC	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	26	1.657432e-03	3
GO:CC	GO:0000791	euchromatin	"A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156]	6	1.957953e-03	3
GO:CC	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	38	4.715169e-03	3
GO:CC	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	8	9.633925e-03	3
GO:CC	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	3	1.822762e-02	3
GO:CC	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	3	1.822762e-02	3
GO:CC	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	5	2.337064e-02	3
GO:CC	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	6	2.675793e-02	3
GO:CC	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	13	2.829143e-02	3
GO:CC	GO:0015030	Cajal body	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]	6	2.984458e-02	3
GO:CC	GO:0042382	paraspeckles	"Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299]	3	3.127095e-02	3
GO:CC	GO:1990023	mitotic spindle midzone	"The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw]	3	3.959516e-02	3
GO:CC	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	4	4.359102e-02	3

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-156842	Eukaryotic Translation Elongation	Eukaryotic Translation Elongation	36	3.241863e-45	3
REAC	REAC:R-HSA-156902	Peptide chain elongation	Peptide chain elongation	35	3.834824e-44	3
REAC	REAC:R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	SRP-dependent cotranslational protein targeting to membrane	37	1.524208e-43	3
REAC	REAC:R-HSA-168273	Influenza Viral RNA Transcription and Replication	Influenza Viral RNA Transcription and Replication	38	3.264952e-42	3
REAC	REAC:R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	L13a-mediated translational silencing of Ceruloplasmin expression	36	6.399192e-42	3
REAC	REAC:R-HSA-72689	Formation of a pool of free 40S subunits	Formation of a pool of free 40S subunits	35	7.877499e-42	3
REAC	REAC:R-HSA-8953854	Metabolism of RNA	Metabolism of RNA	64	9.123500e-42	3
REAC	REAC:R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	34	4.296634e-41	3
REAC	REAC:R-HSA-72613	Eukaryotic Translation Initiation	Eukaryotic Translation Initiation	36	1.160457e-40	3
REAC	REAC:R-HSA-72737	Cap-dependent Translation Initiation	Cap-dependent Translation Initiation	36	1.160457e-40	3
REAC	REAC:R-HSA-192823	Viral mRNA Translation	Viral mRNA Translation	33	2.192501e-40	3
REAC	REAC:R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	GTP hydrolysis and joining of the 60S ribosomal subunit	35	5.409598e-40	3
REAC	REAC:R-HSA-2408557	Selenocysteine synthesis	Selenocysteine synthesis	33	1.241584e-39	3
REAC	REAC:R-HSA-72764	Eukaryotic Translation Termination	Eukaryotic Translation Termination	33	1.241584e-39	3
REAC	REAC:R-HSA-168255	Influenza Infection	Influenza Infection	38	1.765241e-39	3
REAC	REAC:R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	Response of EIF2AK4 (GCN2) to amino acid deficiency	33	3.057908e-38	3
REAC	REAC:R-HSA-927802	Nonsense-Mediated Decay (NMD)	Nonsense-Mediated Decay (NMD)	34	8.330107e-38	3
REAC	REAC:R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	34	8.330107e-38	3
REAC	REAC:R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	Major pathway of rRNA processing in the nucleolus and cytosol	38	1.874467e-36	3
REAC	REAC:R-HSA-72766	Translation	Translation	44	2.480002e-36	3
REAC	REAC:R-HSA-2408522	Selenoamino acid metabolism	Selenoamino acid metabolism	33	5.793918e-36	3
REAC	REAC:R-HSA-8868773	rRNA processing in the nucleus and cytosol	rRNA processing in the nucleus and cytosol	38	1.675781e-35	3
REAC	REAC:R-HSA-72312	rRNA processing	rRNA processing	38	1.318090e-34	3
REAC	REAC:R-HSA-9010553	Regulation of expression of SLITs and ROBOs	Regulation of expression of SLITs and ROBOs	34	1.880878e-31	3
REAC	REAC:R-HSA-9711097	Cellular response to starvation	Cellular response to starvation	33	2.748251e-31	3
REAC	REAC:R-HSA-376176	Signaling by ROBO receptors	Signaling by ROBO receptors	34	9.512271e-28	3
REAC	REAC:R-HSA-9735869	SARS-CoV-1 modulates host translation machinery	SARS-CoV-1 modulates host translation machinery	17	8.663297e-22	3
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	50	1.417251e-21	3
REAC	REAC:R-HSA-72649	Translation initiation complex formation	Translation initiation complex formation	19	5.668998e-21	3
REAC	REAC:R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	19	8.222727e-21	3
REAC	REAC:R-HSA-9754678	SARS-CoV-2 modulates host translation machinery	SARS-CoV-2 modulates host translation machinery	18	1.282225e-20	3
REAC	REAC:R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	Formation of the ternary complex, and subsequently, the 43S complex	18	1.943597e-20	3
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	53	2.301905e-20	3
REAC	REAC:R-HSA-71291	Metabolism of amino acids and derivatives	Metabolism of amino acids and derivatives	34	3.691501e-20	3
REAC	REAC:R-HSA-72702	Ribosomal scanning and start codon recognition	Ribosomal scanning and start codon recognition	18	2.770336e-19	3
REAC	REAC:R-HSA-2262752	Cellular responses to stress	Cellular responses to stress	45	1.095606e-18	3
REAC	REAC:R-HSA-8953897	Cellular responses to stimuli	Cellular responses to stimuli	45	2.217306e-18	3
REAC	REAC:R-HSA-422475	Axon guidance	Axon guidance	36	1.869382e-16	3
REAC	REAC:R-HSA-9675108	Nervous system development	Nervous system development	36	8.180055e-16	3
REAC	REAC:R-HSA-1643685	Disease	Disease	62	8.326718e-16	3
REAC	REAC:R-HSA-9692914	SARS-CoV-1-host interactions	SARS-CoV-1-host interactions	17	8.285623e-14	3
REAC	REAC:R-HSA-9678108	SARS-CoV-1 Infection	SARS-CoV-1 Infection	19	2.696356e-13	3
REAC	REAC:R-HSA-392499	Metabolism of proteins	Metabolism of proteins	60	5.262124e-12	3
REAC	REAC:R-HSA-9705683	SARS-CoV-2-host interactions	SARS-CoV-2-host interactions	19	1.562901e-10	3
REAC	REAC:R-HSA-1266738	Developmental Biology	Developmental Biology	46	3.450510e-10	3
REAC	REAC:R-HSA-9694516	SARS-CoV-2 Infection	SARS-CoV-2 Infection	21	2.521290e-09	3
REAC	REAC:R-HSA-72163	mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway	18	2.657930e-09	3
REAC	REAC:R-HSA-72172	mRNA Splicing	mRNA Splicing	18	4.732724e-09	3
REAC	REAC:R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	Processing of Capped Intron-Containing Pre-mRNA	20	7.408935e-09	3
REAC	REAC:R-HSA-9679506	SARS-CoV Infections	SARS-CoV Infections	23	3.324968e-07	3
REAC	REAC:R-HSA-72165	mRNA Splicing - Minor Pathway	mRNA Splicing - Minor Pathway	6	5.472447e-03	3
REAC	REAC:R-HSA-9725370	Signaling by ALK fusions and activated point mutants	Signaling by ALK fusions and activated point mutants	7	2.224294e-02	3
REAC	REAC:R-HSA-9700206	Signaling by ALK in cancer	Signaling by ALK in cancer	7	2.224294e-02	3
REAC	REAC:R-HSA-9629569	Protein hydroxylation	Protein hydroxylation	4	2.450531e-02	3
REAC	REAC:R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	Diseases of signal transduction by growth factor receptors and second messengers	15	4.282849e-02	3
REAC	REAC:R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	SUMO E3 ligases SUMOylate target proteins	9	4.749135e-02	3

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP477	Cytoplasmic ribosomal proteins	Cytoplasmic ribosomal proteins	33	3.763004e-39	3
WP	WP:WP411	mRNA processing	mRNA processing	18	3.575889e-12	3
WP	WP:WP107	Translation factors	Translation factors	6	7.363335e-03	3
WP	WP:WP3888	VEGFA VEGFR2 signaling	VEGFA VEGFR2 signaling	16	2.040298e-02	3

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:3055	Nop56p-associated pre-rRNA complex	Nop56p-associated pre-rRNA complex	36	5.338110e-33	3
CORUM	CORUM:306	Ribosome, cytoplasmic	Ribosome, cytoplasmic	30	1.467307e-27	3
CORUM	CORUM:338	40S ribosomal subunit, cytoplasmic	40S ribosomal subunit, cytoplasmic	15	1.034637e-14	3
CORUM	CORUM:305	40S ribosomal subunit, cytoplasmic	40S ribosomal subunit, cytoplasmic	15	3.843107e-14	3
CORUM	CORUM:308	60S ribosomal subunit, cytoplasmic	60S ribosomal subunit, cytoplasmic	15	1.502700e-11	3
CORUM	CORUM:1181	C complex spliceosome	C complex spliceosome	11	1.018023e-03	3
CORUM	CORUM:1332	Large Drosha complex	Large Drosha complex	6	2.175190e-03	3
CORUM	CORUM:6838	IGF2BP1 complex	IGF2BP1 complex	4	1.346663e-02	3
CORUM	CORUM:3082	DGCR8 multiprotein complex	DGCR8 multiprotein complex	4	2.198884e-02	3

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:03010	Ribosome	Ribosome	33	4.947279e-32	3
KEGG	KEGG:05171	Coronavirus disease - COVID-19	Coronavirus disease - COVID-19	34	3.819563e-27	3
KEGG	KEGG:03040	Spliceosome	Spliceosome	11	4.501105e-04	3

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0630222	Cervix; squamous epithelial cells[≥Medium]	Cervix; squamous epithelial cells[≥Medium]	99	2.255069e-19	3
HPA	HPA:0600432	Tonsil; germinal center cells[≥Medium]	Tonsil; germinal center cells[≥Medium]	103	6.159622e-19	3
HPA	HPA:0190223	Esophagus; squamous epithelial cells[High]	Esophagus; squamous epithelial cells[High]	66	9.634741e-19	3
HPA	HPA:0100133	Cerebral cortex; neuronal cells[High]	Cerebral cortex; neuronal cells[High]	69	3.037180e-18	3
HPA	HPA:0630223	Cervix; squamous epithelial cells[High]	Cervix; squamous epithelial cells[High]	51	3.983103e-17	3
HPA	HPA:0350473	Pancreas; exocrine glandular cells[High]	Pancreas; exocrine glandular cells[High]	69	8.740231e-17	3
HPA	HPA:0310431	Lymph node; germinal center cells[≥Low]	Lymph node; germinal center cells[≥Low]	110	3.579940e-16	3
HPA	HPA:0600223	Tonsil; squamous epithelial cells[High]	Tonsil; squamous epithelial cells[High]	59	3.772147e-16	3
HPA	HPA:0620223	Vagina; squamous epithelial cells[High]	Vagina; squamous epithelial cells[High]	52	4.435674e-16	3
HPA	HPA:0600433	Tonsil; germinal center cells[High]	Tonsil; germinal center cells[High]	53	2.251752e-15	3
HPA	HPA:0330223	Oral mucosa; squamous epithelial cells[High]	Oral mucosa; squamous epithelial cells[High]	51	4.292020e-15	3
HPA	HPA:0620222	Vagina; squamous epithelial cells[≥Medium]	Vagina; squamous epithelial cells[≥Medium]	97	4.388786e-15	3
HPA	HPA:0310000	Lymph node	Lymph node	122	8.120249e-15	3
HPA	HPA:0420053	Salivary gland; glandular cells[High]	Salivary gland; glandular cells[High]	57	1.407557e-14	3
HPA	HPA:0170053	Endometrium 2; glandular cells[High]	Endometrium 2; glandular cells[High]	54	1.602958e-14	3
HPA	HPA:0250133	Hippocampus; neuronal cells[High]	Hippocampus; neuronal cells[High]	52	3.328155e-14	3
HPA	HPA:0190222	Esophagus; squamous epithelial cells[≥Medium]	Esophagus; squamous epithelial cells[≥Medium]	107	5.293052e-14	3
HPA	HPA:0170252	Endometrium 2; cells in endometrial stroma[≥Medium]	Endometrium 2; cells in endometrial stroma[≥Medium]	62	6.671005e-14	3
HPA	HPA:0630221	Cervix; squamous epithelial cells[≥Low]	Cervix; squamous epithelial cells[≥Low]	111	6.701264e-14	3
HPA	HPA:0050053	Breast; glandular cells[High]	Breast; glandular cells[High]	53	1.364507e-13	3
HPA	HPA:0550053	Stomach 2; glandular cells[High]	Stomach 2; glandular cells[High]	72	1.446785e-13	3
HPA	HPA:0040083	Bone marrow; hematopoietic cells[High]	Bone marrow; hematopoietic cells[High]	55	1.567549e-13	3
HPA	HPA:0330222	Oral mucosa; squamous epithelial cells[≥Medium]	Oral mucosa; squamous epithelial cells[≥Medium]	98	2.876528e-13	3
HPA	HPA:0170251	Endometrium 2; cells in endometrial stroma[≥Low]	Endometrium 2; cells in endometrial stroma[≥Low]	87	4.769493e-13	3
HPA	HPA:0310432	Lymph node; germinal center cells[≥Medium]	Lymph node; germinal center cells[≥Medium]	84	5.152113e-13	3
HPA	HPA:0160251	Endometrium 1; cells in endometrial stroma[≥Low]	Endometrium 1; cells in endometrial stroma[≥Low]	94	6.953460e-13	3
HPA	HPA:0600222	Tonsil; squamous epithelial cells[≥Medium]	Tonsil; squamous epithelial cells[≥Medium]	104	8.241103e-13	3
HPA	HPA:0090192	Cerebellum; cells in molecular layer[≥Medium]	Cerebellum; cells in molecular layer[≥Medium]	76	1.347274e-12	3
HPA	HPA:0090163	Cerebellum; Purkinje cells[High]	Cerebellum; Purkinje cells[High]	55	2.381154e-12	3
HPA	HPA:0600431	Tonsil; germinal center cells[≥Low]	Tonsil; germinal center cells[≥Low]	114	2.728493e-12	3
HPA	HPA:0461411	Skin 1; cells in spinous layer[≥Low]	Skin 1; cells in spinous layer[≥Low]	38	4.225065e-12	3
HPA	HPA:0100132	Cerebral cortex; neuronal cells[≥Medium]	Cerebral cortex; neuronal cells[≥Medium]	103	7.449901e-12	3
HPA	HPA:0250132	Hippocampus; neuronal cells[≥Medium]	Hippocampus; neuronal cells[≥Medium]	94	8.726916e-12	3
HPA	HPA:0380000	Placenta	Placenta	126	1.096108e-11	3
HPA	HPA:0530721	Spleen; cells in white pulp[≥Low]	Spleen; cells in white pulp[≥Low]	95	1.540313e-11	3
HPA	HPA:0040082	Bone marrow; hematopoietic cells[≥Medium]	Bone marrow; hematopoietic cells[≥Medium]	94	1.542976e-11	3
HPA	HPA:0620000	Vagina	Vagina	113	1.563240e-11	3
HPA	HPA:0620221	Vagina; squamous epithelial cells[≥Low]	Vagina; squamous epithelial cells[≥Low]	113	1.563240e-11	3
HPA	HPA:0160053	Endometrium 1; glandular cells[High]	Endometrium 1; glandular cells[High]	52	2.367407e-11	3
HPA	HPA:0170052	Endometrium 2; glandular cells[≥Medium]	Endometrium 2; glandular cells[≥Medium]	101	2.579750e-11	3
HPA	HPA:0471412	Skin 2; cells in spinous layer[≥Medium]	Skin 2; cells in spinous layer[≥Medium]	35	2.916623e-11	3
HPA	HPA:0310442	Lymph node; non-germinal center cells[≥Medium]	Lymph node; non-germinal center cells[≥Medium]	90	3.555702e-11	3
HPA	HPA:0310441	Lymph node; non-germinal center cells[≥Low]	Lymph node; non-germinal center cells[≥Low]	113	4.023084e-11	3
HPA	HPA:0471411	Skin 2; cells in spinous layer[≥Low]	Skin 2; cells in spinous layer[≥Low]	39	6.252765e-11	3
HPA	HPA:0090193	Cerebellum; cells in molecular layer[High]	Cerebellum; cells in molecular layer[High]	40	7.063364e-11	3
HPA	HPA:0080133	Caudate; neuronal cells[High]	Caudate; neuronal cells[High]	44	7.186051e-11	3
HPA	HPA:0090162	Cerebellum; Purkinje cells[≥Medium]	Cerebellum; Purkinje cells[≥Medium]	91	8.512367e-11	3
HPA	HPA:0461391	Skin 1; cells in basal layer[≥Low]	Skin 1; cells in basal layer[≥Low]	39	9.011427e-11	3
HPA	HPA:0610833	Urinary bladder; urothelial cells[High]	Urinary bladder; urothelial cells[High]	61	9.534048e-11	3
HPA	HPA:0471392	Skin 2; cells in basal layer[≥Medium]	Skin 2; cells in basal layer[≥Medium]	36	1.048306e-10	3
HPA	HPA:0190221	Esophagus; squamous epithelial cells[≥Low]	Esophagus; squamous epithelial cells[≥Low]	118	1.165023e-10	3
HPA	HPA:0190000	Esophagus	Esophagus	118	1.165023e-10	3
HPA	HPA:0340461	Ovary; ovarian stroma cells[≥Low]	Ovary; ovarian stroma cells[≥Low]	89	1.274106e-10	3
HPA	HPA:0160252	Endometrium 1; cells in endometrial stroma[≥Medium]	Endometrium 1; cells in endometrial stroma[≥Medium]	64	1.304313e-10	3
HPA	HPA:0610000	Urinary bladder	Urinary bladder	123	1.643445e-10	3
HPA	HPA:0610831	Urinary bladder; urothelial cells[≥Low]	Urinary bladder; urothelial cells[≥Low]	123	1.643445e-10	3
HPA	HPA:0610832	Urinary bladder; urothelial cells[≥Medium]	Urinary bladder; urothelial cells[≥Medium]	111	1.677520e-10	3
HPA	HPA:0300203	Lung; endothelial cells[High]	Lung; endothelial cells[High]	23	1.795576e-10	3
HPA	HPA:0460672	Skin 1; melanocytes[≥Medium]	Skin 1; melanocytes[≥Medium]	85	2.029563e-10	3
HPA	HPA:0350472	Pancreas; exocrine glandular cells[≥Medium]	Pancreas; exocrine glandular cells[≥Medium]	104	2.316807e-10	3
HPA	HPA:0080132	Caudate; neuronal cells[≥Medium]	Caudate; neuronal cells[≥Medium]	90	2.859254e-10	3
HPA	HPA:0210000	Fallopian tube	Fallopian tube	124	2.899963e-10	3
HPA	HPA:0600442	Tonsil; non-germinal center cells[≥Medium]	Tonsil; non-germinal center cells[≥Medium]	91	3.139043e-10	3
HPA	HPA:0500653	Soft tissue 1; fibroblasts[High]	Soft tissue 1; fibroblasts[High]	30	3.224327e-10	3
HPA	HPA:0471462	Skin 2; langerhans cells[≥Medium]	Skin 2; langerhans cells[≥Medium]	33	3.741481e-10	3
HPA	HPA:0600221	Tonsil; squamous epithelial cells[≥Low]	Tonsil; squamous epithelial cells[≥Low]	117	3.821656e-10	3
HPA	HPA:0460181	Skin 1; cells in granular layer[≥Low]	Skin 1; cells in granular layer[≥Low]	34	5.130139e-10	3
HPA	HPA:0461412	Skin 1; cells in spinous layer[≥Medium]	Skin 1; cells in spinous layer[≥Medium]	31	5.730022e-10	3
HPA	HPA:0461461	Skin 1; langerhans cells[≥Low]	Skin 1; langerhans cells[≥Low]	34	6.251686e-10	3
HPA	HPA:0460673	Skin 1; melanocytes[High]	Skin 1; melanocytes[High]	40	6.867999e-10	3
HPA	HPA:0460182	Skin 1; cells in granular layer[≥Medium]	Skin 1; cells in granular layer[≥Medium]	30	7.130780e-10	3
HPA	HPA:0060103	Bronchus; respiratory epithelial cells[High]	Bronchus; respiratory epithelial cells[High]	56	7.157451e-10	3
HPA	HPA:0461392	Skin 1; cells in basal layer[≥Medium]	Skin 1; cells in basal layer[≥Medium]	32	7.485318e-10	3
HPA	HPA:0630000	Cervix	Cervix	119	7.527691e-10	3
HPA	HPA:0350471	Pancreas; exocrine glandular cells[≥Low]	Pancreas; exocrine glandular cells[≥Low]	119	9.684227e-10	3
HPA	HPA:0500652	Soft tissue 1; fibroblasts[≥Medium]	Soft tissue 1; fibroblasts[≥Medium]	70	1.029747e-09	3
HPA	HPA:0050000	Breast	Breast	121	1.048299e-09	3
HPA	HPA:0400000	Rectum	Rectum	127	1.076368e-09	3
HPA	HPA:0471391	Skin 2; cells in basal layer[≥Low]	Skin 2; cells in basal layer[≥Low]	39	1.442991e-09	3
HPA	HPA:0600441	Tonsil; non-germinal center cells[≥Low]	Tonsil; non-germinal center cells[≥Low]	111	1.836231e-09	3
HPA	HPA:0050052	Breast; glandular cells[≥Medium]	Breast; glandular cells[≥Medium]	100	2.523585e-09	3
HPA	HPA:0330000	Oral mucosa	Oral mucosa	112	2.752541e-09	3
HPA	HPA:0330221	Oral mucosa; squamous epithelial cells[≥Low]	Oral mucosa; squamous epithelial cells[≥Low]	112	2.752541e-09	3
HPA	HPA:0460671	Skin 1; melanocytes[≥Low]	Skin 1; melanocytes[≥Low]	102	3.097307e-09	3
HPA	HPA:0050051	Breast; glandular cells[≥Low]	Breast; glandular cells[≥Low]	117	3.643679e-09	3
HPA	HPA:0470181	Skin 2; cells in granular layer[≥Low]	Skin 2; cells in granular layer[≥Low]	33	3.724389e-09	3
HPA	HPA:0600000	Tonsil	Tonsil	125	4.060861e-09	3
HPA	HPA:0470672	Skin 2; melanocytes[≥Medium]	Skin 2; melanocytes[≥Medium]	31	4.348505e-09	3
HPA	HPA:0470182	Skin 2; cells in granular layer[≥Medium]	Skin 2; cells in granular layer[≥Medium]	29	5.052171e-09	3
HPA	HPA:0160052	Endometrium 1; glandular cells[≥Medium]	Endometrium 1; glandular cells[≥Medium]	100	5.064813e-09	3
HPA	HPA:0471461	Skin 2; langerhans cells[≥Low]	Skin 2; langerhans cells[≥Low]	34	9.283378e-09	3
HPA	HPA:0210053	Fallopian tube; glandular cells[High]	Fallopian tube; glandular cells[High]	51	9.488976e-09	3
HPA	HPA:0630053	Cervix; glandular cells[High]	Cervix; glandular cells[High]	42	1.219174e-08	3
HPA	HPA:0320103	Nasopharynx; respiratory epithelial cells[High]	Nasopharynx; respiratory epithelial cells[High]	53	1.314232e-08	3
HPA	HPA:0480000	Small intestine	Small intestine	125	1.352603e-08	3
HPA	HPA:0090191	Cerebellum; cells in molecular layer[≥Low]	Cerebellum; cells in molecular layer[≥Low]	91	1.434886e-08	3
HPA	HPA:0471471	Skin 2; lymphocytes[≥Low]	Skin 2; lymphocytes[≥Low]	34	1.450540e-08	3
HPA	HPA:0530000	Spleen	Spleen	107	1.878084e-08	3
HPA	HPA:0530711	Spleen; cells in red pulp[≥Low]	Spleen; cells in red pulp[≥Low]	101	1.895192e-08	3
HPA	HPA:0350000	Pancreas	Pancreas	121	2.124345e-08	3
HPA	HPA:0540051	Stomach 1; glandular cells[≥Low]	Stomach 1; glandular cells[≥Low]	123	2.442228e-08	3
HPA	HPA:0540000	Stomach 1	Stomach 1	123	2.442228e-08	3
HPA	HPA:0250131	Hippocampus; neuronal cells[≥Low]	Hippocampus; neuronal cells[≥Low]	110	2.737016e-08	3
HPA	HPA:0471472	Skin 2; lymphocytes[≥Medium]	Skin 2; lymphocytes[≥Medium]	30	2.908313e-08	3
HPA	HPA:0540053	Stomach 1; glandular cells[High]	Stomach 1; glandular cells[High]	63	3.361998e-08	3
HPA	HPA:0530722	Spleen; cells in white pulp[≥Medium]	Spleen; cells in white pulp[≥Medium]	67	3.464594e-08	3
HPA	HPA:0471473	Skin 2; lymphocytes[High]	Skin 2; lymphocytes[High]	25	4.154813e-08	3
HPA	HPA:0050093	Breast; myoepithelial cells[High]	Breast; myoepithelial cells[High]	34	4.605571e-08	3
HPA	HPA:0461462	Skin 1; langerhans cells[≥Medium]	Skin 1; langerhans cells[≥Medium]	28	5.018996e-08	3
HPA	HPA:0420051	Salivary gland; glandular cells[≥Low]	Salivary gland; glandular cells[≥Low]	116	5.134802e-08	3
HPA	HPA:0420000	Salivary gland	Salivary gland	116	5.134802e-08	3
HPA	HPA:0460000	Skin 1	Skin 1	119	5.440807e-08	3
HPA	HPA:0461471	Skin 1; lymphocytes[≥Low]	Skin 1; lymphocytes[≥Low]	31	6.699486e-08	3
HPA	HPA:0301363	Lung; alveolar cells type I[High]	Lung; alveolar cells type I[High]	26	7.307559e-08	3
HPA	HPA:0430051	Seminal vesicle; glandular cells[≥Low]	Seminal vesicle; glandular cells[≥Low]	115	7.973331e-08	3
HPA	HPA:0430000	Seminal vesicle	Seminal vesicle	115	7.973331e-08	3
HPA	HPA:0510703	Soft tissue 2; peripheral nerve[High]	Soft tissue 2; peripheral nerve[High]	20	8.217277e-08	3
HPA	HPA:0170051	Endometrium 2; glandular cells[≥Low]	Endometrium 2; glandular cells[≥Low]	114	8.445152e-08	3
HPA	HPA:0380513	Placenta; decidual cells[High]	Placenta; decidual cells[High]	41	9.658519e-08	3
HPA	HPA:0340462	Ovary; ovarian stroma cells[≥Medium]	Ovary; ovarian stroma cells[≥Medium]	56	9.734887e-08	3
HPA	HPA:0470671	Skin 2; melanocytes[≥Low]	Skin 2; melanocytes[≥Low]	31	9.799966e-08	3
HPA	HPA:0471393	Skin 2; cells in basal layer[High]	Skin 2; cells in basal layer[High]	20	9.843260e-08	3
HPA	HPA:0150000	Duodenum	Duodenum	124	1.036753e-07	3
HPA	HPA:0420052	Salivary gland; glandular cells[≥Medium]	Salivary gland; glandular cells[≥Medium]	94	1.381725e-07	3
HPA	HPA:0430052	Seminal vesicle; glandular cells[≥Medium]	Seminal vesicle; glandular cells[≥Medium]	98	1.657755e-07	3
HPA	HPA:0471442	Skin 2; fibrohistiocytic cells[≥Medium]	Skin 2; fibrohistiocytic cells[≥Medium]	33	1.754315e-07	3
HPA	HPA:0550052	Stomach 2; glandular cells[≥Medium]	Stomach 2; glandular cells[≥Medium]	109	2.053705e-07	3
HPA	HPA:0360000	Parathyroid gland	Parathyroid gland	105	2.059774e-07	3
HPA	HPA:0360051	Parathyroid gland; glandular cells[≥Low]	Parathyroid gland; glandular cells[≥Low]	105	2.059774e-07	3
HPA	HPA:0351181	Pancreas; pancreatic endocrine cells[≥Low]	Pancreas; pancreatic endocrine cells[≥Low]	102	2.332717e-07	3
HPA	HPA:0301373	Lung; alveolar cells type II[High]	Lung; alveolar cells type II[High]	29	2.492018e-07	3
HPA	HPA:0040081	Bone marrow; hematopoietic cells[≥Low]	Bone marrow; hematopoietic cells[≥Low]	111	2.494846e-07	3
HPA	HPA:0040000	Bone marrow	Bone marrow	111	2.494846e-07	3
HPA	HPA:0490693	Smooth muscle; smooth muscle cells[High]	Smooth muscle; smooth muscle cells[High]	28	2.593682e-07	3
HPA	HPA:0460203	Skin 1; endothelial cells[High]	Skin 1; endothelial cells[High]	20	3.107199e-07	3
HPA	HPA:0471492	Skin 2; vascular mural cells[≥Medium]	Skin 2; vascular mural cells[≥Medium]	16	3.170271e-07	3
HPA	HPA:0290401	Liver; hepatocytes[≥Low]	Liver; hepatocytes[≥Low]	103	3.477787e-07	3
HPA	HPA:0380512	Placenta; decidual cells[≥Medium]	Placenta; decidual cells[≥Medium]	77	3.700240e-07	3
HPA	HPA:0461473	Skin 1; lymphocytes[High]	Skin 1; lymphocytes[High]	22	4.484073e-07	3
HPA	HPA:0540052	Stomach 1; glandular cells[≥Medium]	Stomach 1; glandular cells[≥Medium]	109	4.789627e-07	3
HPA	HPA:0160253	Endometrium 1; cells in endometrial stroma[High]	Endometrium 1; cells in endometrial stroma[High]	23	5.247757e-07	3
HPA	HPA:0080123	Caudate; glial cells[High]	Caudate; glial cells[High]	29	5.304525e-07	3
HPA	HPA:0220051	Gallbladder; glandular cells[≥Low]	Gallbladder; glandular cells[≥Low]	121	5.452091e-07	3
HPA	HPA:0220000	Gallbladder	Gallbladder	121	5.452091e-07	3
HPA	HPA:0320000	Nasopharynx	Nasopharynx	117	5.612069e-07	3
HPA	HPA:0471441	Skin 2; fibrohistiocytic cells[≥Low]	Skin 2; fibrohistiocytic cells[≥Low]	36	5.878444e-07	3
HPA	HPA:0510653	Soft tissue 2; fibroblasts[High]	Soft tissue 2; fibroblasts[High]	25	6.997184e-07	3
HPA	HPA:0010011	Adipose tissue; adipocytes[≥Low]	Adipose tissue; adipocytes[≥Low]	81	7.500713e-07	3
HPA	HPA:0010000	Adipose tissue	Adipose tissue	81	7.500713e-07	3
HPA	HPA:0300202	Lung; endothelial cells[≥Medium]	Lung; endothelial cells[≥Medium]	28	7.749677e-07	3
HPA	HPA:0471463	Skin 2; langerhans cells[High]	Skin 2; langerhans cells[High]	18	7.897976e-07	3
HPA	HPA:0461443	Skin 1; fibrohistiocytic cells[High]	Skin 1; fibrohistiocytic cells[High]	22	8.203280e-07	3
HPA	HPA:0461442	Skin 1; fibrohistiocytic cells[≥Medium]	Skin 1; fibrohistiocytic cells[≥Medium]	29	8.437670e-07	3
HPA	HPA:0100123	Cerebral cortex; glial cells[High]	Cerebral cortex; glial cells[High]	30	8.866921e-07	3
HPA	HPA:0170000	Endometrium 2	Endometrium 2	114	9.371048e-07	3
HPA	HPA:0100131	Cerebral cortex; neuronal cells[≥Low]	Cerebral cortex; neuronal cells[≥Low]	112	9.408111e-07	3
HPA	HPA:0461413	Skin 1; cells in spinous layer[High]	Skin 1; cells in spinous layer[High]	16	9.513066e-07	3
HPA	HPA:0590053	Thyroid gland; glandular cells[High]	Thyroid gland; glandular cells[High]	51	9.699613e-07	3
HPA	HPA:0250122	Hippocampus; glial cells[≥Medium]	Hippocampus; glial cells[≥Medium]	53	9.921882e-07	3
HPA	HPA:0160051	Endometrium 1; glandular cells[≥Low]	Endometrium 1; glandular cells[≥Low]	113	1.006010e-06	3
HPA	HPA:0310433	Lymph node; germinal center cells[High]	Lymph node; germinal center cells[High]	34	1.058136e-06	3
HPA	HPA:0461472	Skin 1; lymphocytes[≥Medium]	Skin 1; lymphocytes[≥Medium]	26	1.077224e-06	3
HPA	HPA:0300201	Lung; endothelial cells[≥Low]	Lung; endothelial cells[≥Low]	31	1.082945e-06	3
HPA	HPA:0250000	Hippocampus	Hippocampus	113	1.135203e-06	3
HPA	HPA:0550000	Stomach 2	Stomach 2	120	1.243922e-06	3
HPA	HPA:0550051	Stomach 2; glandular cells[≥Low]	Stomach 2; glandular cells[≥Low]	120	1.243922e-06	3
HPA	HPA:0470683	Skin 2; epidermal cells[High]	Skin 2; epidermal cells[High]	36	1.249586e-06	3
HPA	HPA:0570763	Testis; pachytene spermatocytes[High]	Testis; pachytene spermatocytes[High]	34	1.279238e-06	3
HPA	HPA:0160000	Endometrium 1	Endometrium 1	115	1.374331e-06	3
HPA	HPA:0250121	Hippocampus; glial cells[≥Low]	Hippocampus; glial cells[≥Low]	83	1.416455e-06	3
HPA	HPA:0600443	Tonsil; non-germinal center cells[High]	Tonsil; non-germinal center cells[High]	41	1.561894e-06	3
HPA	HPA:0400652	Rectum; fibroblasts[≥Medium]	Rectum; fibroblasts[≥Medium]	12	1.636059e-06	3
HPA	HPA:0570773	Testis; peritubular cells[High]	Testis; peritubular cells[High]	16	1.880062e-06	3
HPA	HPA:0461463	Skin 1; langerhans cells[High]	Skin 1; langerhans cells[High]	16	2.008437e-06	3
HPA	HPA:0570812	Testis; spermatogonia cells[≥Medium]	Testis; spermatogonia cells[≥Medium]	61	2.206962e-06	3
HPA	HPA:0250123	Hippocampus; glial cells[High]	Hippocampus; glial cells[High]	25	2.343870e-06	3
HPA	HPA:0470203	Skin 2; endothelial cells[High]	Skin 2; endothelial cells[High]	19	2.408300e-06	3
HPA	HPA:0080122	Caudate; glial cells[≥Medium]	Caudate; glial cells[≥Medium]	57	2.689187e-06	3
HPA	HPA:0510651	Soft tissue 2; fibroblasts[≥Low]	Soft tissue 2; fibroblasts[≥Low]	82	3.082767e-06	3
HPA	HPA:0220052	Gallbladder; glandular cells[≥Medium]	Gallbladder; glandular cells[≥Medium]	110	3.367569e-06	3
HPA	HPA:0460201	Skin 1; endothelial cells[≥Low]	Skin 1; endothelial cells[≥Low]	31	3.651053e-06	3
HPA	HPA:0470000	Skin 2	Skin 2	114	3.695641e-06	3
HPA	HPA:0570783	Testis; preleptotene spermatocytes[High]	Testis; preleptotene spermatocytes[High]	29	4.392064e-06	3
HPA	HPA:0390052	Prostate; glandular cells[≥Medium]	Prostate; glandular cells[≥Medium]	90	4.448304e-06	3
HPA	HPA:0310443	Lymph node; non-germinal center cells[High]	Lymph node; non-germinal center cells[High]	38	4.739767e-06	3
HPA	HPA:0351183	Pancreas; pancreatic endocrine cells[High]	Pancreas; pancreatic endocrine cells[High]	30	4.867146e-06	3
HPA	HPA:0630051	Cervix; glandular cells[≥Low]	Cervix; glandular cells[≥Low]	100	5.040243e-06	3
HPA	HPA:0351182	Pancreas; pancreatic endocrine cells[≥Medium]	Pancreas; pancreatic endocrine cells[≥Medium]	75	5.087741e-06	3
HPA	HPA:0080131	Caudate; neuronal cells[≥Low]	Caudate; neuronal cells[≥Low]	105	5.306133e-06	3
HPA	HPA:0340000	Ovary	Ovary	97	5.873203e-06	3
HPA	HPA:0400651	Rectum; fibroblasts[≥Low]	Rectum; fibroblasts[≥Low]	12	6.598216e-06	3
HPA	HPA:0050011	Breast; adipocytes[≥Low]	Breast; adipocytes[≥Low]	63	6.673284e-06	3
HPA	HPA:0400053	Rectum; glandular cells[High]	Rectum; glandular cells[High]	60	6.837793e-06	3
HPA	HPA:0020051	Adrenal gland; glandular cells[≥Low]	Adrenal gland; glandular cells[≥Low]	117	6.949554e-06	3
HPA	HPA:0090000	Cerebellum	Cerebellum	115	7.086937e-06	3
HPA	HPA:0020000	Adrenal gland	Adrenal gland	117	7.538601e-06	3
HPA	HPA:0471491	Skin 2; vascular mural cells[≥Low]	Skin 2; vascular mural cells[≥Low]	16	7.881886e-06	3
HPA	HPA:0301372	Lung; alveolar cells type II[≥Medium]	Lung; alveolar cells type II[≥Medium]	38	7.899731e-06	3
HPA	HPA:0030053	Appendix; glandular cells[High]	Appendix; glandular cells[High]	49	8.904468e-06	3
HPA	HPA:0470202	Skin 2; endothelial cells[≥Medium]	Skin 2; endothelial cells[≥Medium]	26	8.914506e-06	3
HPA	HPA:0220053	Gallbladder; glandular cells[High]	Gallbladder; glandular cells[High]	64	9.127922e-06	3
HPA	HPA:0440343	Skeletal muscle; myocytes[High]	Skeletal muscle; myocytes[High]	31	9.692362e-06	3
HPA	HPA:0401302	Rectum; enterocytes[≥Medium]	Rectum; enterocytes[≥Medium]	20	9.830732e-06	3
HPA	HPA:0180000	Epididymis	Epididymis	116	1.030681e-05	3
HPA	HPA:0180051	Epididymis; glandular cells[≥Low]	Epididymis; glandular cells[≥Low]	116	1.030681e-05	3
HPA	HPA:0301371	Lung; alveolar cells type II[≥Low]	Lung; alveolar cells type II[≥Low]	43	1.129118e-05	3
HPA	HPA:0461441	Skin 1; fibrohistiocytic cells[≥Low]	Skin 1; fibrohistiocytic cells[≥Low]	31	1.194893e-05	3
HPA	HPA:0100122	Cerebral cortex; glial cells[≥Medium]	Cerebral cortex; glial cells[≥Medium]	61	1.204868e-05	3
HPA	HPA:0500651	Soft tissue 1; fibroblasts[≥Low]	Soft tissue 1; fibroblasts[≥Low]	82	1.209373e-05	3
HPA	HPA:0471493	Skin 2; vascular mural cells[High]	Skin 2; vascular mural cells[High]	12	1.237754e-05	3
HPA	HPA:0460183	Skin 1; cells in granular layer[High]	Skin 1; cells in granular layer[High]	16	1.248545e-05	3
HPA	HPA:0471413	Skin 2; cells in spinous layer[High]	Skin 2; cells in spinous layer[High]	16	1.248545e-05	3
HPA	HPA:0301362	Lung; alveolar cells type I[≥Medium]	Lung; alveolar cells type I[≥Medium]	31	1.258553e-05	3
HPA	HPA:0470201	Skin 2; endothelial cells[≥Low]	Skin 2; endothelial cells[≥Low]	31	1.291563e-05	3
HPA	HPA:0050092	Breast; myoepithelial cells[≥Medium]	Breast; myoepithelial cells[≥Medium]	76	1.316187e-05	3
HPA	HPA:0180052	Epididymis; glandular cells[≥Medium]	Epididymis; glandular cells[≥Medium]	99	1.382976e-05	3
HPA	HPA:0170253	Endometrium 2; cells in endometrial stroma[High]	Endometrium 2; cells in endometrial stroma[High]	19	1.467326e-05	3
HPA	HPA:0010012	Adipose tissue; adipocytes[≥Medium]	Adipose tissue; adipocytes[≥Medium]	54	1.651904e-05	3
HPA	HPA:0100121	Cerebral cortex; glial cells[≥Low]	Cerebral cortex; glial cells[≥Low]	90	1.803991e-05	3
HPA	HPA:0030072	Appendix; lymphoid tissue[≥Medium]	Appendix; lymphoid tissue[≥Medium]	65	1.832943e-05	3
HPA	HPA:0080000	Caudate	Caudate	112	1.838378e-05	3
HPA	HPA:0570811	Testis; spermatogonia cells[≥Low]	Testis; spermatogonia cells[≥Low]	66	1.882876e-05	3
HPA	HPA:0461493	Skin 1; vascular mural cells[High]	Skin 1; vascular mural cells[High]	12	2.057603e-05	3
HPA	HPA:0390051	Prostate; glandular cells[≥Low]	Prostate; glandular cells[≥Low]	109	2.109546e-05	3
HPA	HPA:0390000	Prostate	Prostate	109	2.109546e-05	3
HPA	HPA:0290000	Liver	Liver	105	2.368229e-05	3
HPA	HPA:0130000	Colon	Colon	124	2.380971e-05	3
HPA	HPA:0020052	Adrenal gland; glandular cells[≥Medium]	Adrenal gland; glandular cells[≥Medium]	102	2.441860e-05	3
HPA	HPA:0380522	Placenta; trophoblastic cells[≥Medium]	Placenta; trophoblastic cells[≥Medium]	91	2.737822e-05	3
HPA	HPA:0150053	Duodenum; glandular cells[High]	Duodenum; glandular cells[High]	59	2.850038e-05	3
HPA	HPA:0060000	Bronchus	Bronchus	116	3.160385e-05	3
HPA	HPA:0430053	Seminal vesicle; glandular cells[High]	Seminal vesicle; glandular cells[High]	41	3.254952e-05	3
HPA	HPA:0570793	Testis; round or early spermatids[High]	Testis; round or early spermatids[High]	33	3.432335e-05	3
HPA	HPA:0010013	Adipose tissue; adipocytes[High]	Adipose tissue; adipocytes[High]	21	3.483541e-05	3
HPA	HPA:0460202	Skin 1; endothelial cells[≥Medium]	Skin 1; endothelial cells[≥Medium]	24	3.832974e-05	3
HPA	HPA:0180053	Epididymis; glandular cells[High]	Epididymis; glandular cells[High]	47	3.849542e-05	3
HPA	HPA:0301361	Lung; alveolar cells type I[≥Low]	Lung; alveolar cells type I[≥Low]	34	3.994650e-05	3
HPA	HPA:0320102	Nasopharynx; respiratory epithelial cells[≥Medium]	Nasopharynx; respiratory epithelial cells[≥Medium]	87	4.095493e-05	3
HPA	HPA:0570782	Testis; preleptotene spermatocytes[≥Medium]	Testis; preleptotene spermatocytes[≥Medium]	41	4.560205e-05	3
HPA	HPA:0530712	Spleen; cells in red pulp[≥Medium]	Spleen; cells in red pulp[≥Medium]	66	5.728444e-05	3
HPA	HPA:0380523	Placenta; trophoblastic cells[High]	Placenta; trophoblastic cells[High]	48	6.248564e-05	3
HPA	HPA:0030000	Appendix	Appendix	119	6.528958e-05	3
HPA	HPA:0300411	Lung; macrophages[≥Low]	Lung; macrophages[≥Low]	109	6.716914e-05	3
HPA	HPA:0470673	Skin 2; melanocytes[High]	Skin 2; melanocytes[High]	18	7.003965e-05	3
HPA	HPA:0130203	Colon; endothelial cells[High]	Colon; endothelial cells[High]	29	7.133929e-05	3
HPA	HPA:0050091	Breast; myoepithelial cells[≥Low]	Breast; myoepithelial cells[≥Low]	97	7.299228e-05	3
HPA	HPA:0090161	Cerebellum; Purkinje cells[≥Low]	Cerebellum; Purkinje cells[≥Low]	96	7.441582e-05	3
HPA	HPA:0470183	Skin 2; cells in granular layer[High]	Skin 2; cells in granular layer[High]	15	7.825409e-05	3
HPA	HPA:0401332	Rectum; mucosal lymphoid cells[≥Medium]	Rectum; mucosal lymphoid cells[≥Medium]	19	7.999573e-05	3
HPA	HPA:0570813	Testis; spermatogonia cells[High]	Testis; spermatogonia cells[High]	40	8.941456e-05	3
HPA	HPA:0461492	Skin 1; vascular mural cells[≥Medium]	Skin 1; vascular mural cells[≥Medium]	13	1.180421e-04	3
HPA	HPA:0461452	Skin 1; hair follicles[≥Medium]	Skin 1; hair follicles[≥Medium]	16	1.228465e-04	3
HPA	HPA:0380521	Placenta; trophoblastic cells[≥Low]	Placenta; trophoblastic cells[≥Low]	104	1.310114e-04	3
HPA	HPA:0130651	Colon; fibroblasts[≥Low]	Colon; fibroblasts[≥Low]	10	1.503198e-04	3
HPA	HPA:0300000	Lung	Lung	114	1.600104e-04	3
HPA	HPA:0210051	Fallopian tube; glandular cells[≥Low]	Fallopian tube; glandular cells[≥Low]	97	1.758451e-04	3
HPA	HPA:0100201	Cerebral cortex; endothelial cells[≥Low]	Cerebral cortex; endothelial cells[≥Low]	84	1.808356e-04	3
HPA	HPA:0390053	Prostate; glandular cells[High]	Prostate; glandular cells[High]	37	1.921042e-04	3
HPA	HPA:0471443	Skin 2; fibrohistiocytic cells[High]	Skin 2; fibrohistiocytic cells[High]	20	1.981506e-04	3
HPA	HPA:0460663	Skin 1; keratinocytes[High]	Skin 1; keratinocytes[High]	24	1.998799e-04	3
HPA	HPA:0400892	Rectum; goblet cells[≥Medium]	Rectum; goblet cells[≥Medium]	17	2.048349e-04	3
HPA	HPA:0030071	Appendix; lymphoid tissue[≥Low]	Appendix; lymphoid tissue[≥Low]	85	2.218372e-04	3
HPA	HPA:0510652	Soft tissue 2; fibroblasts[≥Medium]	Soft tissue 2; fibroblasts[≥Medium]	57	2.253510e-04	3
HPA	HPA:0270353	Kidney; cells in glomeruli[High]	Kidney; cells in glomeruli[High]	28	2.379856e-04	3
HPA	HPA:0050013	Breast; adipocytes[High]	Breast; adipocytes[High]	16	2.606180e-04	3
HPA	HPA:0380511	Placenta; decidual cells[≥Low]	Placenta; decidual cells[≥Low]	86	2.842886e-04	3
HPA	HPA:0630052	Cervix; glandular cells[≥Medium]	Cervix; glandular cells[≥Medium]	76	2.944064e-04	3
HPA	HPA:0570792	Testis; round or early spermatids[≥Medium]	Testis; round or early spermatids[≥Medium]	46	3.183773e-04	3
HPA	HPA:0490691	Smooth muscle; smooth muscle cells[≥Low]	Smooth muscle; smooth muscle cells[≥Low]	93	3.244385e-04	3
HPA	HPA:0490000	Smooth muscle	Smooth muscle	93	3.244385e-04	3
HPA	HPA:0050012	Breast; adipocytes[≥Medium]	Breast; adipocytes[≥Medium]	39	3.673116e-04	3
HPA	HPA:0401333	Rectum; mucosal lymphoid cells[High]	Rectum; mucosal lymphoid cells[High]	12	3.901337e-04	3
HPA	HPA:0270362	Kidney; cells in tubules[≥Medium]	Kidney; cells in tubules[≥Medium]	97	3.993344e-04	3
HPA	HPA:0570791	Testis; round or early spermatids[≥Low]	Testis; round or early spermatids[≥Low]	52	4.312698e-04	3
HPA	HPA:0131332	Colon; mucosal lymphoid cells[≥Medium]	Colon; mucosal lymphoid cells[≥Medium]	17	5.010990e-04	3
HPA	HPA:0461451	Skin 1; hair follicles[≥Low]	Skin 1; hair follicles[≥Low]	17	5.201063e-04	3
HPA	HPA:0400891	Rectum; goblet cells[≥Low]	Rectum; goblet cells[≥Low]	18	5.448390e-04	3
HPA	HPA:0320101	Nasopharynx; respiratory epithelial cells[≥Low]	Nasopharynx; respiratory epithelial cells[≥Low]	96	5.510460e-04	3
HPA	HPA:0130892	Colon; goblet cells[≥Medium]	Colon; goblet cells[≥Medium]	16	7.477140e-04	3
HPA	HPA:0570000	Testis	Testis	127	7.606900e-04	3
HPA	HPA:0570803	Testis; sertoli cells[High]	Testis; sertoli cells[High]	22	7.705439e-04	3
HPA	HPA:0131302	Colon; enterocytes[≥Medium]	Colon; enterocytes[≥Medium]	17	8.339998e-04	3
HPA	HPA:0290402	Liver; hepatocytes[≥Medium]	Liver; hepatocytes[≥Medium]	71	8.488171e-04	3
HPA	HPA:0461393	Skin 1; cells in basal layer[High]	Skin 1; cells in basal layer[High]	12	8.670031e-04	3
HPA	HPA:0030442	Appendix; non-germinal center cells[≥Medium]	Appendix; non-germinal center cells[≥Medium]	14	8.675273e-04	3
HPA	HPA:0401301	Rectum; enterocytes[≥Low]	Rectum; enterocytes[≥Low]	20	8.740531e-04	3
HPA	HPA:0381192	Placenta; cytotrophoblasts[≥Medium]	Placenta; cytotrophoblasts[≥Medium]	18	8.756658e-04	3
HPA	HPA:0400242	Rectum; peripheral nerve/ganglion[≥Medium]	Rectum; peripheral nerve/ganglion[≥Medium]	12	9.153749e-04	3
HPA	HPA:0400203	Rectum; endothelial cells[High]	Rectum; endothelial cells[High]	9	9.902378e-04	3
HPA	HPA:0360053	Parathyroid gland; glandular cells[High]	Parathyroid gland; glandular cells[High]	39	1.002610e-03	3
HPA	HPA:0570772	Testis; peritubular cells[≥Medium]	Testis; peritubular cells[≥Medium]	20	1.275587e-03	3
HPA	HPA:0130201	Colon; endothelial cells[≥Low]	Colon; endothelial cells[≥Low]	94	1.287547e-03	3
HPA	HPA:0130653	Colon; fibroblasts[High]	Colon; fibroblasts[High]	7	1.367527e-03	3
HPA	HPA:0570771	Testis; peritubular cells[≥Low]	Testis; peritubular cells[≥Low]	24	1.398646e-03	3
HPA	HPA:0270351	Kidney; cells in glomeruli[≥Low]	Kidney; cells in glomeruli[≥Low]	88	1.429109e-03	3
HPA	HPA:0020053	Adrenal gland; glandular cells[High]	Adrenal gland; glandular cells[High]	50	1.484223e-03	3
HPA	HPA:0030892	Appendix; goblet cells[≥Medium]	Appendix; goblet cells[≥Medium]	15	1.504952e-03	3
HPA	HPA:0131292	Colon; endocrine cells[≥Medium]	Colon; endocrine cells[≥Medium]	17	1.712275e-03	3
HPA	HPA:0570781	Testis; preleptotene spermatocytes[≥Low]	Testis; preleptotene spermatocytes[≥Low]	44	1.721880e-03	3
HPA	HPA:0461491	Skin 1; vascular mural cells[≥Low]	Skin 1; vascular mural cells[≥Low]	13	1.873377e-03	3
HPA	HPA:0031302	Appendix; enterocytes[≥Medium]	Appendix; enterocytes[≥Medium]	16	1.939434e-03	3
HPA	HPA:0500113	Soft tissue 1; chondrocytes[High]	Soft tissue 1; chondrocytes[High]	15	1.964677e-03	3
HPA	HPA:0510000	Soft tissue 2	Soft tissue 2	88	2.022214e-03	3
HPA	HPA:0381203	Placenta; hofbauer cells[High]	Placenta; hofbauer cells[High]	14	2.030574e-03	3
HPA	HPA:0291163	Liver; cholangiocytes[High]	Liver; cholangiocytes[High]	15	2.039676e-03	3
HPA	HPA:0401331	Rectum; mucosal lymphoid cells[≥Low]	Rectum; mucosal lymphoid cells[≥Low]	20	2.108299e-03	3
HPA	HPA:0590051	Thyroid gland; glandular cells[≥Low]	Thyroid gland; glandular cells[≥Low]	109	2.153008e-03	3
HPA	HPA:0590000	Thyroid gland	Thyroid gland	109	2.153008e-03	3
HPA	HPA:0060101	Bronchus; respiratory epithelial cells[≥Low]	Bronchus; respiratory epithelial cells[≥Low]	96	2.218013e-03	3
HPA	HPA:0130891	Colon; goblet cells[≥Low]	Colon; goblet cells[≥Low]	17	2.446909e-03	3
HPA	HPA:0131301	Colon; enterocytes[≥Low]	Colon; enterocytes[≥Low]	19	2.628711e-03	3
HPA	HPA:0360052	Parathyroid gland; glandular cells[≥Medium]	Parathyroid gland; glandular cells[≥Medium]	78	2.679014e-03	3
HPA	HPA:0400653	Rectum; fibroblasts[High]	Rectum; fibroblasts[High]	7	2.694520e-03	3
HPA	HPA:0151352	Duodenum; paneth cells[≥Medium]	Duodenum; paneth cells[≥Medium]	13	2.900413e-03	3
HPA	HPA:0080121	Caudate; glial cells[≥Low]	Caudate; glial cells[≥Low]	80	2.921933e-03	3
HPA	HPA:0130202	Colon; endothelial cells[≥Medium]	Colon; endothelial cells[≥Medium]	69	2.969196e-03	3
HPA	HPA:0131331	Colon; mucosal lymphoid cells[≥Low]	Colon; mucosal lymphoid cells[≥Low]	19	3.022783e-03	3
HPA	HPA:0400201	Rectum; endothelial cells[≥Low]	Rectum; endothelial cells[≥Low]	13	3.157046e-03	3
HPA	HPA:0130053	Colon; glandular cells[High]	Colon; glandular cells[High]	51	3.272441e-03	3
HPA	HPA:0030441	Appendix; non-germinal center cells[≥Low]	Appendix; non-germinal center cells[≥Low]	15	3.275149e-03	3
HPA	HPA:0381193	Placenta; cytotrophoblasts[High]	Placenta; cytotrophoblasts[High]	14	3.389589e-03	3
HPA	HPA:0210052	Fallopian tube; glandular cells[≥Medium]	Fallopian tube; glandular cells[≥Medium]	81	3.430882e-03	3
HPA	HPA:0100000	Cerebral cortex	Cerebral cortex	118	3.489396e-03	3
HPA	HPA:0030073	Appendix; lymphoid tissue[High]	Appendix; lymphoid tissue[High]	24	3.546523e-03	3
HPA	HPA:0460642	Skin 1; Langerhans[≥Medium]	Skin 1; Langerhans[≥Medium]	54	3.608091e-03	3
HPA	HPA:0381202	Placenta; hofbauer cells[≥Medium]	Placenta; hofbauer cells[≥Medium]	16	3.682099e-03	3
HPA	HPA:0400202	Rectum; endothelial cells[≥Medium]	Rectum; endothelial cells[≥Medium]	11	3.818048e-03	3
HPA	HPA:0151302	Duodenum; enterocytes[≥Medium]	Duodenum; enterocytes[≥Medium]	17	3.901572e-03	3
HPA	HPA:0570761	Testis; pachytene spermatocytes[≥Low]	Testis; pachytene spermatocytes[≥Low]	50	4.041185e-03	3
HPA	HPA:0481351	Small intestine; paneth cells[≥Low]	Small intestine; paneth cells[≥Low]	13	4.050992e-03	3
HPA	HPA:0270000	Kidney	Kidney	119	4.193256e-03	3
HPA	HPA:0570732	Testis; Leydig cells[≥Medium]	Testis; Leydig cells[≥Medium]	89	4.278908e-03	3
HPA	HPA:0381191	Placenta; cytotrophoblasts[≥Low]	Placenta; cytotrophoblasts[≥Low]	18	4.305118e-03	3
HPA	HPA:0481352	Small intestine; paneth cells[≥Medium]	Small intestine; paneth cells[≥Medium]	12	4.822717e-03	3
HPA	HPA:0131333	Colon; mucosal lymphoid cells[High]	Colon; mucosal lymphoid cells[High]	10	4.961328e-03	3
HPA	HPA:0401303	Rectum; enterocytes[High]	Rectum; enterocytes[High]	12	5.039977e-03	3
HPA	HPA:0381201	Placenta; hofbauer cells[≥Low]	Placenta; hofbauer cells[≥Low]	17	5.107481e-03	3
HPA	HPA:0130652	Colon; fibroblasts[≥Medium]	Colon; fibroblasts[≥Medium]	8	5.329143e-03	3
HPA	HPA:0400052	Rectum; glandular cells[≥Medium]	Rectum; glandular cells[≥Medium]	97	5.785483e-03	3
HPA	HPA:0481302	Small intestine; enterocytes[≥Medium]	Small intestine; enterocytes[≥Medium]	17	5.912388e-03	3
HPA	HPA:0060102	Bronchus; respiratory epithelial cells[≥Medium]	Bronchus; respiratory epithelial cells[≥Medium]	83	6.577895e-03	3
HPA	HPA:0131291	Colon; endocrine cells[≥Low]	Colon; endocrine cells[≥Low]	17	6.635827e-03	3
HPA	HPA:0530723	Spleen; cells in white pulp[High]	Spleen; cells in white pulp[High]	25	6.711410e-03	3
HPA	HPA:0480053	Small intestine; glandular cells[High]	Small intestine; glandular cells[High]	52	6.850996e-03	3
HPA	HPA:0590052	Thyroid gland; glandular cells[≥Medium]	Thyroid gland; glandular cells[≥Medium]	91	7.110140e-03	3
HPA	HPA:0400051	Rectum; glandular cells[≥Low]	Rectum; glandular cells[≥Low]	107	7.371763e-03	3
HPA	HPA:0401292	Rectum; endocrine cells[≥Medium]	Rectum; endocrine cells[≥Medium]	16	7.570612e-03	3
HPA	HPA:0461482	Skin 1; sebaceous glands[≥Medium]	Skin 1; sebaceous glands[≥Medium]	10	8.061293e-03	3
HPA	HPA:0151351	Duodenum; paneth cells[≥Low]	Duodenum; paneth cells[≥Low]	13	8.204299e-03	3
HPA	HPA:0500000	Soft tissue 1	Soft tissue 1	88	8.820074e-03	3
HPA	HPA:0500703	Soft tissue 1; peripheral nerve[High]	Soft tissue 1; peripheral nerve[High]	12	9.111734e-03	3
HPA	HPA:0570762	Testis; pachytene spermatocytes[≥Medium]	Testis; pachytene spermatocytes[≥Medium]	42	9.670148e-03	3
HPA	HPA:0031292	Appendix; endocrine cells[≥Medium]	Appendix; endocrine cells[≥Medium]	15	9.839170e-03	3
HPA	HPA:0481303	Small intestine; enterocytes[High]	Small intestine; enterocytes[High]	12	1.070517e-02	3
HPA	HPA:0530713	Spleen; cells in red pulp[High]	Spleen; cells in red pulp[High]	24	1.126495e-02	3
HPA	HPA:0270361	Kidney; cells in tubules[≥Low]	Kidney; cells in tubules[≥Low]	106	1.175498e-02	3
HPA	HPA:0100203	Cerebral cortex; endothelial cells[High]	Cerebral cortex; endothelial cells[High]	16	1.176145e-02	3
HPA	HPA:0300412	Lung; macrophages[≥Medium]	Lung; macrophages[≥Medium]	82	1.186196e-02	3
HPA	HPA:0500111	Soft tissue 1; chondrocytes[≥Low]	Soft tissue 1; chondrocytes[≥Low]	46	1.242529e-02	3
HPA	HPA:0400893	Rectum; goblet cells[High]	Rectum; goblet cells[High]	11	1.348051e-02	3
HPA	HPA:0241103	Heart muscle; cardiomyocytes[High]	Heart muscle; cardiomyocytes[High]	30	1.359010e-02	3
HPA	HPA:0030052	Appendix; glandular cells[≥Medium]	Appendix; glandular cells[≥Medium]	89	1.372723e-02	3
HPA	HPA:0150892	Duodenum; goblet cells[≥Medium]	Duodenum; goblet cells[≥Medium]	14	1.385492e-02	3
HPA	HPA:0481301	Small intestine; enterocytes[≥Low]	Small intestine; enterocytes[≥Low]	19	1.440296e-02	3
HPA	HPA:0490692	Smooth muscle; smooth muscle cells[≥Medium]	Smooth muscle; smooth muscle cells[≥Medium]	59	1.517968e-02	3
HPA	HPA:0030891	Appendix; goblet cells[≥Low]	Appendix; goblet cells[≥Low]	15	1.648416e-02	3
HPA	HPA:0131303	Colon; enterocytes[High]	Colon; enterocytes[High]	11	1.665474e-02	3
HPA	HPA:0480892	Small intestine; goblet cells[≥Medium]	Small intestine; goblet cells[≥Medium]	14	1.678581e-02	3
HPA	HPA:0460662	Skin 1; keratinocytes[≥Medium]	Skin 1; keratinocytes[≥Medium]	61	1.696505e-02	3
HPA	HPA:0100202	Cerebral cortex; endothelial cells[≥Medium]	Cerebral cortex; endothelial cells[≥Medium]	50	1.702077e-02	3
HPA	HPA:0400241	Rectum; peripheral nerve/ganglion[≥Low]	Rectum; peripheral nerve/ganglion[≥Low]	12	1.903225e-02	3
HPA	HPA:0270352	Kidney; cells in glomeruli[≥Medium]	Kidney; cells in glomeruli[≥Medium]	58	2.178871e-02	3
HPA	HPA:0570733	Testis; Leydig cells[High]	Testis; Leydig cells[High]	39	2.285810e-02	3
HPA	HPA:0211092	Fallopian tube; non-ciliated cells[≥Medium]	Fallopian tube; non-ciliated cells[≥Medium]	19	2.333679e-02	3
HPA	HPA:0030432	Appendix; germinal center cells[≥Medium]	Appendix; germinal center cells[≥Medium]	11	2.400043e-02	3
HPA	HPA:0401293	Rectum; endocrine cells[High]	Rectum; endocrine cells[High]	12	2.542251e-02	3
HPA	HPA:0031303	Appendix; enterocytes[High]	Appendix; enterocytes[High]	10	2.543518e-02	3
HPA	HPA:0090183	Cerebellum; cells in granular layer[High]	Cerebellum; cells in granular layer[High]	22	2.582056e-02	3
HPA	HPA:0401291	Rectum; endocrine cells[≥Low]	Rectum; endocrine cells[≥Low]	16	2.736674e-02	3
HPA	HPA:0150891	Duodenum; goblet cells[≥Low]	Duodenum; goblet cells[≥Low]	15	2.831066e-02	3
HPA	HPA:0461453	Skin 1; hair follicles[High]	Skin 1; hair follicles[High]	8	2.975793e-02	3
HPA	HPA:0500702	Soft tissue 1; peripheral nerve[≥Medium]	Soft tissue 1; peripheral nerve[≥Medium]	32	3.178645e-02	3
HPA	HPA:0480891	Small intestine; goblet cells[≥Low]	Small intestine; goblet cells[≥Low]	15	3.333850e-02	3
HPA	HPA:0510702	Soft tissue 2; peripheral nerve[≥Medium]	Soft tissue 2; peripheral nerve[≥Medium]	35	3.340708e-02	3
HPA	HPA:0130241	Colon; peripheral nerve/ganglion[≥Low]	Colon; peripheral nerve/ganglion[≥Low]	82	3.979510e-02	3
HPA	HPA:0460653	Skin 1; fibroblasts[High]	Skin 1; fibroblasts[High]	20	4.194025e-02	3
HPA	HPA:0130052	Colon; glandular cells[≥Medium]	Colon; glandular cells[≥Medium]	93	4.228322e-02	3
HPA	HPA:0031291	Appendix; endocrine cells[≥Low]	Appendix; endocrine cells[≥Low]	15	4.233891e-02	3
HPA	HPA:0461481	Skin 1; sebaceous glands[≥Low]	Skin 1; sebaceous glands[≥Low]	10	4.401874e-02	3
HPA	HPA:0130893	Colon; goblet cells[High]	Colon; goblet cells[High]	10	4.964120e-02	3
HPA	HPA:0340463	Ovary; ovarian stroma cells[High]	Ovary; ovarian stroma cells[High]	14	4.989290e-02	3

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-615-3p	hsa-mir-615-3p	hsa-mir-615-3p	44	2.885545e-17	3
MIRNA	MIRNA:hsa-mir-92a-3p	hsa-mir-92a-3p	hsa-mir-92a-3p	40	3.462329e-09	3
MIRNA	MIRNA:hsa-mir-16-5p	hsa-mir-16-5p	hsa-mir-16-5p	42	1.142443e-08	3
MIRNA	MIRNA:hsa-mir-1296-5p	hsa-mir-1296-5p	hsa-mir-1296-5p	11	5.850082e-06	3
MIRNA	MIRNA:hsa-mir-877-3p	hsa-mir-877-3p	hsa-mir-877-3p	22	1.008710e-05	3
MIRNA	MIRNA:hsa-mir-193b-3p	hsa-mir-193b-3p	hsa-mir-193b-3p	24	2.470346e-04	3
MIRNA	MIRNA:hsa-let-7c-3p	hsa-let-7c-3p	hsa-let-7c-3p	8	1.693810e-03	3
MIRNA	MIRNA:hsa-mir-744-5p	hsa-mir-744-5p	hsa-mir-744-5p	15	2.581428e-03	3
MIRNA	MIRNA:hsa-mir-320a	hsa-mir-320a	hsa-mir-320a	35	2.620126e-03	3
MIRNA	MIRNA:hsa-mir-505-3p	hsa-mir-505-3p	hsa-mir-505-3p	11	3.022024e-03	3
MIRNA	MIRNA:hsa-mir-191-5p	hsa-mir-191-5p	hsa-mir-191-5p	7	4.648736e-03	3
MIRNA	MIRNA:hsa-mir-423-3p	hsa-mir-423-3p	hsa-mir-423-3p	14	5.075572e-03	3
MIRNA	MIRNA:hsa-mir-149-5p	hsa-mir-149-5p	hsa-mir-149-5p	14	7.618601e-03	3
MIRNA	MIRNA:hsa-mir-1273d	hsa-mir-1273d	hsa-mir-1273d	18	8.826034e-03	3
MIRNA	MIRNA:hsa-mir-100-5p	hsa-mir-100-5p	hsa-mir-100-5p	11	1.185520e-02	3
MIRNA	MIRNA:hsa-mir-92b-3p	hsa-mir-92b-3p	hsa-mir-92b-3p	18	1.316664e-02	3
MIRNA	MIRNA:hsa-mir-652-3p	hsa-mir-652-3p	hsa-mir-652-3p	8	1.909034e-02	3
MIRNA	MIRNA:hsa-mir-186-5p	hsa-mir-186-5p	hsa-mir-186-5p	19	2.179415e-02	3
MIRNA	MIRNA:hsa-mir-15b-5p	hsa-mir-15b-5p	hsa-mir-15b-5p	19	2.909826e-02	3
MIRNA	MIRNA:hsa-mir-6729-5p	hsa-mir-6729-5p	hsa-mir-6729-5p	6	3.075724e-02	3
MIRNA	MIRNA:hsa-mir-34a-5p	hsa-mir-34a-5p	hsa-mir-34a-5p	16	4.752406e-02	3

HP

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0002669	Osteosarcoma	A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor.	10	1.385437e-09	3
HP	HP:0002863	Myelodysplasia	Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.	13	4.254601e-08	3
HP	HP:0004808	Acute myeloid leukemia	A form of leukemia characterized by overproduction of an early myeloid cell.	11	1.375573e-07	3
HP	HP:0012133	Erythroid hypoplasia	Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.	8	4.803033e-07	3
HP	HP:0012131	Abnormal number of erythroid precursors	A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.	9	1.605081e-06	3
HP	HP:0011904	Persistence of hemoglobin F	Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent.	8	2.248507e-06	3
HP	HP:0001895	Normochromic anemia	Normochromic anemia	8	3.530424e-06	3
HP	HP:0031640	Abnormal radial artery morphology	Any structural anomaly of the radial artery.	7	4.861886e-06	3
HP	HP:0030270	Elevated red cell adenosine deaminase activity	Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine.	7	4.861886e-06	3
HP	HP:0020118	Radial artery aplasia	Congenital absence of the radial artery.	7	4.861886e-06	3
HP	HP:4000209	Abnormal erythrocyte adenosine deaminase activity	Activity of adenosine deaminase in red blood cells outside the limits of normal.	7	6.514815e-06	3
HP	HP:0005532	Macrocytic dyserythropoietic anemia	Macrocytic dyserythropoietic anemia	7	8.621925e-06	3
HP	HP:0001894	Thrombocytosis	Increased numbers of platelets in the peripheral blood.	9	1.457116e-05	3
HP	HP:0012410	Pure red cell aplasia	A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction.	7	1.460492e-05	3
HP	HP:0002488	Acute leukemia	A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).	11	1.861388e-05	3
HP	HP:0040276	Adenocarcinoma of the colon	Adenocarcinoma of the colon	7	4.647703e-05	3
HP	HP:0001227	Abnormality of the thenar eminence	An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb.	7	4.647703e-05	3
HP	HP:0000912	Sprengel anomaly	A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other).	8	5.342365e-05	3
HP	HP:0006758	Malignant genitourinary tract tumor	The presence of a malignant neoplasm of the genital system.	7	5.726707e-05	3
HP	HP:0011902	Abnormal hemoglobin	Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes.	9	5.857472e-05	3
HP	HP:0100242	Sarcoma	A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant.	12	6.923952e-05	3
HP	HP:0010622	Neoplasm of the skeletal system	A tumor (abnormal growth of tissue) of the skeleton.	10	7.008294e-05	3
HP	HP:0001896	Reticulocytopenia	A reduced number of reticulocytes in the peripheral blood.	7	7.010474e-05	3
HP	HP:0001909	Leukemia	A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.	12	9.011717e-05	3
HP	HP:0009777	Absent thumb	Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues.	8	9.554282e-05	3
HP	HP:0004377	Hematological neoplasm	Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue).	15	1.006985e-04	3
HP	HP:0040275	Adenocarcinoma of the large intestine	A malignant epithelial tumor with a glandular organization that originates in the large intestine.	7	1.031828e-04	3
HP	HP:0000185	Cleft soft palate	Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency.	8	1.256563e-04	3
HP	HP:0009944	Partial duplication of thumb phalanx	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	7	1.769796e-04	3
HP	HP:0040273	Adenocarcinoma of the intestines	A malignant epithelial tumor with a glandular organization that originates in the intestines.	7	2.098216e-04	3
HP	HP:0001874	Abnormality of neutrophils	A neutrophil abnormality.	14	2.189188e-04	3
HP	HP:0009999	Partial duplication of the phalanx of hand	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	7	2.476635e-04	3
HP	HP:0001911	Abnormal granulocyte morphology	Any structural abnormality or abnormal count of granulocytes.	15	2.625626e-04	3
HP	HP:0009380	Finger aplasia	A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers).	9	2.824699e-04	3
HP	HP:0030272	Abnormal erythrocyte enzyme concentration or activity	An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme.	7	5.348447e-04	3
HP	HP:0001972	Macrocytic anemia	A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).	8	6.671179e-04	3
HP	HP:0010974	Abnormal myeloid leukocyte morphology	An abnormality of myeloid leukocytes.	15	7.672048e-04	3
HP	HP:0001875	Decreased total neutrophil count	Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group.	12	7.701661e-04	3
HP	HP:0008772	Aplasia/Hypoplasia of the external ear	The presence of aplasia or developmental hypoplasia of all or part of the external ear.	12	7.701661e-04	3
HP	HP:0005518	Increased mean corpuscular volume	Larger than normal size of erythrocytes.	7	8.145479e-04	3
HP	HP:0008771	Aplasia/Hypoplasia of the ear	The presence of aplasia or developmental hypoplasia of the ear.	12	1.099459e-03	3
HP	HP:0011792	Neoplasm by histology	Neoplasm categorized according to type of histological abnormality.	15	1.240336e-03	3
HP	HP:0100273	Neoplasm of the colon	Neoplasm of the colon	8	1.486592e-03	3
HP	HP:0032309	Abnormal granulocyte count	Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group.	13	1.873473e-03	3
HP	HP:0011991	Abnormal total neutrophil count	A deviation from the normal range of neutrophil cell counts in the circulation.	12	1.963041e-03	3
HP	HP:0000085	Horseshoe kidney	A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline.	10	2.175137e-03	3
HP	HP:0009942	Duplication of thumb phalanx	Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	7	2.215142e-03	3
HP	HP:0008551	Microtia	Underdevelopment of the external ear.	11	2.550991e-03	3
HP	HP:0025065	Abnormal mean corpuscular volume	A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters.	7	2.778964e-03	3
HP	HP:0009778	Short thumb	Hypoplasia (congenital reduction in size) of the thumb.	9	4.166345e-03	3
HP	HP:0001790	Nonimmune hydrops fetalis	A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens .	7	4.271187e-03	3
HP	HP:0011893	Abnormal leukocyte count	Number of leukocytes per volume of blood beyond normal limits.	17	4.940934e-03	3
HP	HP:0001199	Triphalangeal thumb	A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb.	7	6.381086e-03	3
HP	HP:0006749	Malignant gastrointestinal tract tumors	Malignant gastrointestinal tract tumors	7	1.017801e-02	3
HP	HP:0001087	Developmental glaucoma	Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma.	7	1.017801e-02	3
HP	HP:0002672	Gastrointestinal carcinoma	Gastrointestinal carcinoma	7	1.017801e-02	3
HP	HP:0000519	Developmental cataract	A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens.	9	1.122651e-02	3
HP	HP:0100736	Abnormal soft palate morphology	An abnormality of the soft palate.	12	1.248549e-02	3
HP	HP:0007379	Neoplasm of the genitourinary tract	A tumor (abnormal growth of tissue) of the genitourinary system.	11	1.610022e-02	3
HP	HP:0009601	Aplasia/Hypoplasia of the thumb	Hypoplastic/small or absent thumb.	9	1.664215e-02	3
HP	HP:0000294	Low anterior hairline	Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella.	9	1.757382e-02	3
HP	HP:0100834	Neoplasm of the large intestine	The presence of a neoplasm of the large intestine.	8	1.929984e-02	3
HP	HP:0004312	Abnormal reticulocyte morphology	A reticulocyte abnormality.	7	2.171585e-02	3
HP	HP:0000980	Pallor	Abnormally pale skin.	9	2.293198e-02	3
HP	HP:0001877	Abnormal erythrocyte morphology	Any structural abnormality of erythrocytes (red-blood cells).	19	2.339295e-02	3
HP	HP:0100542	Abnormal localization of kidney	An abnormal site of the kidney.	11	2.405428e-02	3
HP	HP:0001903	Anemia	A reduction in erythrocytes volume or hemoglobin concentration.	18	2.489896e-02	3
HP	HP:0010987	Abnormal cellular immune system morphology	An abnormality of the morphology or counts of the cells that make up the immune system.	18	2.601402e-02	3
HP	HP:0001881	Abnormal leukocyte morphology	An abnormality of leukocytes.	18	2.601402e-02	3
HP	HP:0001882	Decreased total leukocyte count	An abnormal decreased number of leukocytes in the blood.	9	2.817041e-02	3
HP	HP:0000465	Webbed neck	Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline.	8	3.359190e-02	3
HP	HP:0011793	Neoplasm by anatomical site	Neoplasm categorized according to the anatomical site of origin of the neoplasm.	22	3.899519e-02	3
HP	HP:0000218	High palate	Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective).	20	3.950934e-02	3
HP	HP:0001421	Abnormality of the musculature of the hand	Abnormality of the musculature of the hand	8	4.234322e-02	3
HP	HP:0032251	Abnormal immune system morphology	Abnormal immune system morphology	18	4.616989e-02	3

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M04826_1	Factor: p300; motif: ACNTCCG; match class: 1	Factor: p300; motif: ACNTCCG; match class: 1	148	0.000003	3
TF	TF:M00803	Factor: E2F; motif: GGCGSG	Factor: E2F; motif: GGCGSG	137	0.000004	3
TF	TF:M01660	Factor: GABP-alpha; motif: CTTCCK	Factor: GABP-alpha; motif: CTTCCK	123	0.000006	3
TF	TF:M01078	Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN	Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN	96	0.000008	3
TF	TF:M08526_1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1	146	0.000012	3
TF	TF:M10438_1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	Factor: ZF5; motif: GGSGCGCGS; match class: 1	145	0.000023	3
TF	TF:M00426_1	Factor: E2F; motif: TTTSGCGS; match class: 1	Factor: E2F; motif: TTTSGCGS; match class: 1	80	0.000033	3
TF	TF:M11527_1	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1	87	0.000037	3
TF	TF:M00426	Factor: E2F; motif: TTTSGCGS	Factor: E2F; motif: TTTSGCGS	127	0.000038	3
TF	TF:M09905	Factor: SAP-1; motif: NNCCGGAAGTGN	Factor: SAP-1; motif: NNCCGGAAGTGN	100	0.000057	3
TF	TF:M11435	Factor: Elk-1; motif: NNCCGGAAGTN	Factor: Elk-1; motif: NNCCGGAAGTN	125	0.000060	3
TF	TF:M00425_1	Factor: E2F; motif: TTTCGCGC; match class: 1	Factor: E2F; motif: TTTCGCGC; match class: 1	75	0.000061	3
TF	TF:M03967	Factor: ELF3; motif: WACCCGGAAGTAN	Factor: ELF3; motif: WACCCGGAAGTAN	94	0.000071	3
TF	TF:M11430	Factor: PEA3; motif: NACCGGAAGTN	Factor: PEA3; motif: NACCGGAAGTN	119	0.000071	3
TF	TF:M11527	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN	88	0.000088	3
TF	TF:M11882_1	Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1	Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1	123	0.000090	3
TF	TF:M12599_1	Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1	Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1	148	0.000091	3
TF	TF:M00740	Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC	Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC	116	0.000092	3
TF	TF:M11018_1	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1	149	0.000107	3
TF	TF:M01660_1	Factor: GABP-alpha; motif: CTTCCK; match class: 1	Factor: GABP-alpha; motif: CTTCCK; match class: 1	72	0.000116	3
TF	TF:M07380	Factor: E2F-4; motif: NTTTCSCGCC	Factor: E2F-4; motif: NTTTCSCGCC	133	0.000127	3
TF	TF:M12600	Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN	Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN	102	0.000132	3
TF	TF:M04714	Factor: Elf-1; motif: ACTTCCGGG	Factor: Elf-1; motif: ACTTCCGGG	95	0.000157	3
TF	TF:M11435_1	Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1	Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1	77	0.000208	3
TF	TF:M12601	Factor: ELF4; motif: NCCACTTCCGGNNNN	Factor: ELF4; motif: NCCACTTCCGGNNNN	76	0.000271	3
TF	TF:M00050	Factor: E2F; motif: TTTSGCGC	Factor: E2F; motif: TTTSGCGC	88	0.000341	3
TF	TF:M00716	Factor: ZF5; motif: GSGCGCGR	Factor: ZF5; motif: GSGCGCGR	149	0.000401	3
TF	TF:M00333	Factor: ZF5; motif: NRNGNGCGCGCWN	Factor: ZF5; motif: NRNGNGCGCGCWN	144	0.000409	3
TF	TF:M11419	Factor: ER81; motif: NNCCGGAWGYN	Factor: ER81; motif: NNCCGGAWGYN	79	0.000410	3
TF	TF:M00425	Factor: E2F; motif: TTTCGCGC	Factor: E2F; motif: TTTCGCGC	119	0.000436	3
TF	TF:M00025	Factor: Elk-1; motif: NNNNCCGGAARTNN	Factor: Elk-1; motif: NNNNCCGGAARTNN	111	0.000446	3
TF	TF:M00940	Factor: E2F-1; motif: NTTTCGCGCS	Factor: E2F-1; motif: NTTTCGCGCS	94	0.000471	3
TF	TF:M08526	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN	Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN	152	0.000503	3
TF	TF:M02065_1	Factor: ER81; motif: RCCGGAARYN; match class: 1	Factor: ER81; motif: RCCGGAARYN; match class: 1	87	0.000521	3
TF	TF:M04710	Factor: CHD2; motif: TCTCGCGAG	Factor: CHD2; motif: TCTCGCGAG	138	0.000534	3
TF	TF:M03977_1	Factor: ETS1; motif: ACCGGAARYN; match class: 1	Factor: ETS1; motif: ACCGGAARYN; match class: 1	66	0.000590	3
TF	TF:M03925_1	Factor: YY2; motif: NCCGCCATNTY; match class: 1	Factor: YY2; motif: NCCGCCATNTY; match class: 1	22	0.000592	3
TF	TF:M04691_1	Factor: Kaiso; motif: TCTCGCGAG; match class: 1	Factor: Kaiso; motif: TCTCGCGAG; match class: 1	114	0.000720	3
TF	TF:M13031	Factor: ETV4; motif: ACCGGAAGTN	Factor: ETV4; motif: ACCGGAAGTN	116	0.000733	3
TF	TF:M07380_1	Factor: E2F-4; motif: NTTTCSCGCC; match class: 1	Factor: E2F-4; motif: NTTTCSCGCC; match class: 1	95	0.000806	3
TF	TF:M11450	Factor: Elf-1; motif: NANSCGGAAGTR	Factor: Elf-1; motif: NANSCGGAAGTR	74	0.000884	3
TF	TF:M02071	Factor: ETV7; motif: NCCGGAANNN	Factor: ETV7; motif: NCCGGAANNN	111	0.000910	3
TF	TF:M00025_1	Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1	Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1	63	0.000988	3
TF	TF:M01820	Factor: CREM; motif: TGACGTCASYN	Factor: CREM; motif: TGACGTCASYN	80	0.001001	3
TF	TF:M09894_1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	137	0.001032	3
TF	TF:M04744_1	Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1	Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1	67	0.001087	3
TF	TF:M11447	Factor: Elf-1; motif: NAMCCGGAAGTN	Factor: Elf-1; motif: NAMCCGGAAGTN	92	0.001117	3
TF	TF:M11434	Factor: Elk-1; motif: NRSCGGAAGNN	Factor: Elk-1; motif: NRSCGGAAGNN	96	0.001316	3
TF	TF:M02065	Factor: ER81; motif: RCCGGAARYN	Factor: ER81; motif: RCCGGAARYN	129	0.001334	3
TF	TF:M02052	Factor: EHF; motif: CSCGGAARTN	Factor: EHF; motif: CSCGGAARTN	110	0.001424	3
TF	TF:M11428	Factor: PEA3; motif: NACCGGAAGTN	Factor: PEA3; motif: NACCGGAAGTN	87	0.001453	3
TF	TF:M04691	Factor: Kaiso; motif: TCTCGCGAG	Factor: Kaiso; motif: TCTCGCGAG	143	0.001501	3
TF	TF:M03924	Factor: YY1; motif: NNCGCCATTNN	Factor: YY1; motif: NNCGCCATTNN	110	0.001563	3
TF	TF:M09966_1	Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1	Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1	16	0.001621	3
TF	TF:M02068	Factor: etv3; motif: ACCGGAAGYN	Factor: etv3; motif: ACCGGAAGYN	53	0.001629	3
TF	TF:M08982	Factor: YY1; motif: NAANATGGCGNNN	Factor: YY1; motif: NAANATGGCGNNN	86	0.001651	3
TF	TF:M13032	Factor: ETV5; motif: ACCGGAAGTN	Factor: ETV5; motif: ACCGGAAGTN	105	0.001742	3
TF	TF:M07250	Factor: E2F-1; motif: NNNSSCGCSAANN	Factor: E2F-1; motif: NNNSSCGCSAANN	115	0.001756	3
TF	TF:M09901	Factor: nerf; motif: NNNCCGGAAGTGN	Factor: nerf; motif: NNNCCGGAAGTGN	71	0.002017	3
TF	TF:M04810	Factor: USF2; motif: AAGTCACG	Factor: USF2; motif: AAGTCACG	79	0.002091	3
TF	TF:M11526_1	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN; match class: 1	83	0.002157	3
TF	TF:M07415	Factor: Elf-1; motif: AWCCCGGAAGTN	Factor: Elf-1; motif: AWCCCGGAAGTN	93	0.002355	3
TF	TF:M11526	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN	Factor: E2F-3; motif: NTTTTGGCGCCAAAAN	86	0.002496	3
TF	TF:M02070	Factor: TEL1; motif: CNCGGAANNN	Factor: TEL1; motif: CNCGGAANNN	115	0.002549	3
TF	TF:M02069	Factor: Erm; motif: ACCGGAAGTN	Factor: Erm; motif: ACCGGAAGTN	84	0.002613	3
TF	TF:M11392_1	Factor: Erg; motif: NACCGGAARYN; match class: 1	Factor: Erg; motif: NACCGGAARYN; match class: 1	50	0.002661	3
TF	TF:M11451	Factor: Elf-1; motif: NANCCGGAAGTN	Factor: Elf-1; motif: NANCCGGAAGTN	84	0.002849	3
TF	TF:M01770	Factor: XBP-1; motif: WNNGMCACGTC	Factor: XBP-1; motif: WNNGMCACGTC	116	0.002918	3
TF	TF:M11427	Factor: PEA3; motif: NACCGGAAGTN	Factor: PEA3; motif: NACCGGAAGTN	113	0.003070	3
TF	TF:M11603_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	131	0.003240	3
TF	TF:M02059_1	Factor: ELK-1; motif: ACCGGAAGTN; match class: 1	Factor: ELK-1; motif: ACCGGAAGTN; match class: 1	55	0.003503	3
TF	TF:M00333_1	Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1	Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1	126	0.003800	3
TF	TF:M03982	Factor: ETV4; motif: ACCGGAAGTN	Factor: ETV4; motif: ACCGGAAGTN	83	0.003830	3
TF	TF:M11424	Factor: Erm; motif: NNSCGGAWGYN	Factor: Erm; motif: NNSCGGAWGYN	94	0.003987	3
TF	TF:M00427	Factor: E2F; motif: TTTSGCGS	Factor: E2F; motif: TTTSGCGS	105	0.004115	3
TF	TF:M02062	Factor: Erg; motif: ACCGGAAGTN	Factor: Erg; motif: ACCGGAAGTN	93	0.004164	3
TF	TF:M02062_1	Factor: Erg; motif: ACCGGAAGTN; match class: 1	Factor: Erg; motif: ACCGGAAGTN; match class: 1	44	0.004299	3
TF	TF:M08377_1	Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1	Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1	67	0.004377	3
TF	TF:M11400_1	Factor: Fli-1; motif: NACCGGAARTN; match class: 1	Factor: Fli-1; motif: NACCGGAARTN; match class: 1	59	0.004666	3
TF	TF:M10438	Factor: ZF5; motif: GGSGCGCGS	Factor: ZF5; motif: GGSGCGCGS	148	0.004761	3
TF	TF:M08913	Factor: FLI-1; motif: NAYTTCCGGT	Factor: FLI-1; motif: NAYTTCCGGT	95	0.004934	3
TF	TF:M01035	Factor: YY1; motif: NYNKCCATNTT	Factor: YY1; motif: NYNKCCATNTT	74	0.004966	3
TF	TF:M02063	Factor: c-ets-1; motif: ACCGGAWGTN	Factor: c-ets-1; motif: ACCGGAWGTN	89	0.005122	3
TF	TF:M13119	Factor: ZBTB11; motif: RCTTCCGGNNSNNNN	Factor: ZBTB11; motif: RCTTCCGGNNSNNNN	73	0.005188	3
TF	TF:M08525_1	Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1	Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1	143	0.005592	3
TF	TF:M03925	Factor: YY2; motif: NCCGCCATNTY	Factor: YY2; motif: NCCGCCATNTY	63	0.005724	3
TF	TF:M00940_1	Factor: E2F-1; motif: NTTTCGCGCS; match class: 1	Factor: E2F-1; motif: NTTTCGCGCS; match class: 1	43	0.006167	3
TF	TF:M11018	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN	Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN	151	0.007446	3
TF	TF:M11529	Factor: E2F-2; motif: GCGCGCGCNCS	Factor: E2F-2; motif: GCGCGCGCNCS	148	0.007584	3
TF	TF:M02066	Factor: PEA3; motif: RCCGGAAGYN	Factor: PEA3; motif: RCCGGAAGYN	84	0.008081	3
TF	TF:M11400	Factor: Fli-1; motif: NACCGGAARTN	Factor: Fli-1; motif: NACCGGAARTN	107	0.008157	3
TF	TF:M00716_1	Factor: ZF5; motif: GSGCGCGR; match class: 1	Factor: ZF5; motif: GSGCGCGR; match class: 1	136	0.008338	3
TF	TF:M09904	Factor: Elk-1; motif: RCCGGAAGTGN	Factor: Elk-1; motif: RCCGGAAGTGN	93	0.008446	3
TF	TF:M11415	Factor: GABP-alpha; motif: NRCCGGAAGTN	Factor: GABP-alpha; motif: NRCCGGAAGTN	49	0.008898	3
TF	TF:M03990	Factor: GABPA; motif: ACCGGAAGTN	Factor: GABPA; motif: ACCGGAAGTN	68	0.009216	3
TF	TF:M00430	Factor: E2F-1; motif: NTTSGCGG	Factor: E2F-1; motif: NTTSGCGG	92	0.009521	3
TF	TF:M02067	Factor: ER71; motif: ACCGGAARYN	Factor: ER71; motif: ACCGGAARYN	74	0.009709	3
TF	TF:M08759	Factor: c-Ets-2; motif: NCCGGAAGTG	Factor: c-Ets-2; motif: NCCGGAAGTG	94	0.009909	3
TF	TF:M11452	Factor: Elf-1; motif: NANGCGGAAGTR	Factor: Elf-1; motif: NANGCGGAAGTR	77	0.010133	3
TF	TF:M03977	Factor: ETS1; motif: ACCGGAARYN	Factor: ETS1; motif: ACCGGAARYN	111	0.010317	3
TF	TF:M00430_1	Factor: E2F-1; motif: NTTSGCGG; match class: 1	Factor: E2F-1; motif: NTTSGCGG; match class: 1	41	0.010656	3
TF	TF:M04287	Factor: BARHL2; motif: NNTAAAYGNN	Factor: BARHL2; motif: NNTAAAYGNN	60	0.010763	3
TF	TF:M07612	Factor: PSF; motif: KWATCCGN	Factor: PSF; motif: KWATCCGN	71	0.010920	3
TF	TF:M11396_1	Factor: Erg; motif: NACCGGAARTN; match class: 1	Factor: Erg; motif: NACCGGAARTN; match class: 1	65	0.011240	3
TF	TF:M03962_1	Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT; match class: 1	Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT; match class: 1	79	0.011285	3
TF	TF:M12600_1	Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN; match class: 1	Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN; match class: 1	48	0.011312	3
TF	TF:M11448	Factor: Elf-1; motif: NANGCGGAAGTN	Factor: Elf-1; motif: NANGCGGAAGTN	88	0.012497	3
TF	TF:M11414	Factor: GABP-alpha; motif: NACCGGAAGTN	Factor: GABP-alpha; motif: NACCGGAAGTN	45	0.013483	3
TF	TF:M04869_1	Factor: Egr-1; motif: GCGCATGCG; match class: 1	Factor: Egr-1; motif: GCGCATGCG; match class: 1	109	0.014113	3
TF	TF:M10104	Factor: YY1; motif: CAARATGGCGGC	Factor: YY1; motif: CAARATGGCGGC	74	0.014224	3
TF	TF:M10578	Factor: Barhl-1; motif: NTAAACGN	Factor: Barhl-1; motif: NTAAACGN	75	0.014410	3
TF	TF:M08759_1	Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1	Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1	45	0.014484	3
TF	TF:M11058_1	Factor: Hey1; motif: NGCRCGYGYN; match class: 1	Factor: Hey1; motif: NGCRCGYGYN; match class: 1	106	0.015187	3
TF	TF:M00736_1	Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1	Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1	62	0.015822	3
TF	TF:M13031_1	Factor: ETV4; motif: ACCGGAAGTN; match class: 1	Factor: ETV4; motif: ACCGGAAGTN; match class: 1	64	0.016136	3
TF	TF:M11434_1	Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1	Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1	45	0.016697	3
TF	TF:M11531	Factor: E2F-2; motif: GCGCGCGCGYW	Factor: E2F-2; motif: GCGCGCGCGYW	130	0.016707	3
TF	TF:M02059	Factor: ELK-1; motif: ACCGGAAGTN	Factor: ELK-1; motif: ACCGGAAGTN	102	0.017426	3
TF	TF:M08913_1	Factor: FLI-1; motif: NAYTTCCGGT; match class: 1	Factor: FLI-1; motif: NAYTTCCGGT; match class: 1	46	0.017673	3
TF	TF:M09607	Factor: SAP-1; motif: ACCGGAAGTNN	Factor: SAP-1; motif: ACCGGAAGTNN	62	0.018116	3
TF	TF:M02052_1	Factor: EHF; motif: CSCGGAARTN; match class: 1	Factor: EHF; motif: CSCGGAARTN; match class: 1	56	0.018183	3
TF	TF:M10785	Factor: hoxa9; motif: RTCGTWANNN	Factor: hoxa9; motif: RTCGTWANNN	70	0.018244	3
TF	TF:M00431	Factor: E2F-1; motif: TTTSGCGS	Factor: E2F-1; motif: TTTSGCGS	85	0.018303	3
TF	TF:M00024_1	Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1	Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1	42	0.018310	3
TF	TF:M00737_1	Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1	Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1	45	0.018559	3
TF	TF:M08205_1	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1	Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1	110	0.018813	3
TF	TF:M03966	Factor: ELF1; motif: AACCCGGAAGTR	Factor: ELF1; motif: AACCCGGAAGTR	79	0.019148	3
TF	TF:M03983	Factor: ETV5; motif: NCCGGAWGYN	Factor: ETV5; motif: NCCGGAWGYN	47	0.019197	3
TF	TF:M10436	Factor: YY1; motif: CAANATGGCGGC	Factor: YY1; motif: CAANATGGCGGC	92	0.019859	3
TF	TF:M07052	Factor: NRF-1; motif: GCGCMTGCGCN	Factor: NRF-1; motif: GCGCMTGCGCN	36	0.020412	3
TF	TF:M11392	Factor: Erg; motif: NACCGGAARYN	Factor: Erg; motif: NACCGGAARYN	96	0.020812	3
TF	TF:M02044	Factor: YY1; motif: GCCGCCATTTTG	Factor: YY1; motif: GCCGCCATTTTG	75	0.021287	3
TF	TF:M01861	Factor: ATF-1; motif: TNACGTCAN	Factor: ATF-1; motif: TNACGTCAN	76	0.021697	3
TF	TF:M09606	Factor: nerf; motif: NRRNSCGGAAGNRNNNN	Factor: nerf; motif: NRRNSCGGAAGNRNNNN	76	0.024133	3
TF	TF:M00803_1	Factor: E2F; motif: GGCGSG; match class: 1	Factor: E2F; motif: GGCGSG; match class: 1	108	0.026063	3
TF	TF:M11428_1	Factor: PEA3; motif: NACCGGAAGTN; match class: 1	Factor: PEA3; motif: NACCGGAAGTN; match class: 1	36	0.026642	3
TF	TF:M11425_1	Factor: PEA3; motif: NACCGGAAGTN; match class: 1	Factor: PEA3; motif: NACCGGAAGTN; match class: 1	38	0.027061	3
TF	TF:M01752_1	Factor: ERG; motif: ACCGGAART; match class: 1	Factor: ERG; motif: ACCGGAART; match class: 1	52	0.027202	3
TF	TF:M11425	Factor: PEA3; motif: NACCGGAAGTN	Factor: PEA3; motif: NACCGGAAGTN	85	0.032535	3
TF	TF:M04744	Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA	Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA	106	0.032643	3
TF	TF:M08875	Factor: E2F; motif: NNTTTCGCGCN	Factor: E2F; motif: NNTTTCGCGCN	75	0.038907	3
TF	TF:M11530_1	Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1	Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1	130	0.039477	3
TF	TF:M01752	Factor: ERG; motif: ACCGGAART	Factor: ERG; motif: ACCGGAART	101	0.040000	3
TF	TF:M09887	Factor: CREB1; motif: NRRTGACGTMA	Factor: CREB1; motif: NRRTGACGTMA	72	0.041812	3
TF	TF:M02064	Factor: c-ets-2; motif: ACCGGAWRTN	Factor: c-ets-2; motif: ACCGGAWRTN	112	0.042358	3
TF	TF:M09641	Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN	Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN	47	0.042432	3
TF	TF:M03962	Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT	Factor: E2F-3; motif: NNTTTTGGCGCCAAAACT	113	0.042974	3
TF	TF:M00539	Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN	Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN	78	0.048688	3
TF	TF:M00539_1	Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN; match class: 1	Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN; match class: 1	78	0.048688	3
TF	TF:M00615_1	Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN; match class: 1	Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN; match class: 1	78	0.048977	3
TF	TF:M00615	Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN	Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN	78	0.048977	3
TF	TF:M00738	Factor: E2F-4:DP-1; motif: TTTSGCGC	Factor: E2F-4:DP-1; motif: TTTSGCGC	104	0.049180	3

Community 4

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	118	7.254609e-41	4
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	144	6.139165e-26	4
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	85	1.831878e-23	4
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	60	7.874801e-21	4
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	60	1.628150e-20	4
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	60	1.667696e-20	4
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	60	1.667696e-20	4
GO:CC	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	47	8.186849e-18	4
GO:CC	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	56	1.717326e-14	4
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	64	9.244273e-14	4
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	53	6.756479e-12	4
GO:CC	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	70	7.335098e-12	4
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	53	7.441418e-12	4
GO:CC	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	32	1.227039e-11	4
GO:CC	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	10	5.121610e-11	4
GO:CC	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	23	1.110793e-10	4
GO:CC	GO:0005832	chaperonin-containing T-complex	"A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267]	6	6.538924e-09	4
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	46	1.097789e-08	4
GO:CC	GO:0044297	cell body	"The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]	22	1.508316e-08	4
GO:CC	GO:0099080	supramolecular complex	"A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]	34	4.540317e-08	4
GO:CC	GO:0099512	supramolecular fiber	"A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos]	29	4.782781e-08	4
GO:CC	GO:0099081	supramolecular polymer	"A polymeric supramolecular structure." [GOC:dos]	29	5.698677e-08	4
GO:CC	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	26	9.611417e-08	4
GO:CC	GO:0099513	polymeric cytoskeletal fiber	"A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos]	25	1.060809e-07	4
GO:CC	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	138	1.092818e-07	4
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	82	1.107639e-07	4
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	82	1.116624e-07	4
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	36	1.124116e-07	4
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	82	1.365625e-07	4
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	82	1.365625e-07	4
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	82	1.365625e-07	4
GO:CC	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	37	1.772310e-07	4
GO:CC	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	67	1.813051e-07	4
GO:CC	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917]	44	2.455200e-07	4
GO:CC	GO:0034774	secretory granule lumen	"The volume enclosed by the membrane of a secretory granule." [GOC:rph]	16	2.480641e-07	4
GO:CC	GO:0060205	cytoplasmic vesicle lumen	"The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles]	16	3.099971e-07	4
GO:CC	GO:0031983	vesicle lumen	"The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles]	16	3.239749e-07	4
GO:CC	GO:0099503	secretory vesicle	"A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]	28	4.389381e-07	4
GO:CC	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	146	4.431959e-07	4
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	142	5.641992e-07	4
GO:CC	GO:0005952	cAMP-dependent protein kinase complex	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [PMID:18178622]	5	5.994478e-07	4
GO:CC	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	42	6.301257e-07	4
GO:CC	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	89	1.519778e-06	4
GO:CC	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	36	1.755945e-06	4
GO:CC	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	22	2.447433e-06	4
GO:CC	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	59	3.004089e-06	4
GO:CC	GO:0022624	proteasome accessory complex	"A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu]	6	5.071343e-06	4
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	137	5.406747e-06	4
GO:CC	GO:0000502	proteasome complex	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome]	8	6.227195e-06	4
GO:CC	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	102	7.425248e-06	4
GO:CC	GO:0016234	inclusion body	"A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]	8	1.240191e-05	4
GO:CC	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	21	1.240235e-05	4
GO:CC	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	68	1.727107e-05	4
GO:CC	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	23	1.754080e-05	4
GO:CC	GO:0000323	lytic vacuole	"A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]	21	2.122008e-05	4
GO:CC	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	21	2.122008e-05	4
GO:CC	GO:0150034	distal axon	"That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468]	13	2.375521e-05	4
GO:CC	GO:0031594	neuromuscular junction	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]	8	2.569754e-05	4
GO:CC	GO:0042470	melanosome	"A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]	9	3.042056e-05	4
GO:CC	GO:0048770	pigment granule	"A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]	9	3.042056e-05	4
GO:CC	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	22	3.510278e-05	4
GO:CC	GO:0002199	zona pellucida receptor complex	"A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732]	4	5.054999e-05	4
GO:CC	GO:1904813	ficolin-1-rich granule lumen	"Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620]	9	6.288234e-05	4
GO:CC	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	16	1.113751e-04	4
GO:CC	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	5	1.166924e-04	4
GO:CC	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	20	1.447617e-04	4
GO:CC	GO:1905369	endopeptidase complex	"A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]	8	1.589434e-04	4
GO:CC	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	9	1.666255e-04	4
GO:CC	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	18	1.990499e-04	4
GO:CC	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	12	3.058830e-04	4
GO:CC	GO:0098857	membrane microdomain	"A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it." [PMID:20044567, PMID:26253820]	12	3.284154e-04	4
GO:CC	GO:0008540	proteasome regulatory particle, base subcomplex	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	4	3.499861e-04	4
GO:CC	GO:1902911	protein kinase complex	"A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918]	9	3.738479e-04	4
GO:CC	GO:0042582	azurophil granule	"Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule]	9	4.167248e-04	4
GO:CC	GO:0005766	primary lysosome	"A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194]	9	4.167248e-04	4
GO:CC	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	19	5.134865e-04	4
GO:CC	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	14	6.450741e-04	4
GO:CC	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	9	8.135681e-04	4
GO:CC	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	12	9.234810e-04	4
GO:CC	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	125	1.020603e-03	4
GO:CC	GO:0030427	site of polarized growth	"Any part of a cell where non-isotropic growth takes place." [GOC:mah]	9	1.036026e-03	4
GO:CC	GO:0035578	azurophil granule lumen	"The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095]	7	1.042324e-03	4
GO:CC	GO:1905368	peptidase complex	"A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]	8	1.082900e-03	4
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	20	1.339256e-03	4
GO:CC	GO:0005775	vacuolar lumen	"The volume enclosed within the vacuolar membrane." [ISBN:0198506732]	9	1.434270e-03	4
GO:CC	GO:0101002	ficolin-1-rich granule	"Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154]	9	1.716095e-03	4
GO:CC	GO:0005774	vacuolar membrane	"The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]	14	2.822457e-03	4
GO:CC	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	94	3.240726e-03	4
GO:CC	GO:0031968	organelle outer membrane	"The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah]	10	3.953552e-03	4
GO:CC	GO:0019867	outer membrane	"The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators]	10	4.227950e-03	4
GO:CC	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	13	4.642579e-03	4
GO:CC	GO:0098852	lytic vacuole membrane	"The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos]	13	4.642579e-03	4
GO:CC	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	5	5.931102e-03	4
GO:CC	GO:0036477	somatodendritic compartment	"The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL]	18	7.958876e-03	4
GO:CC	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	9	9.228332e-03	4
GO:CC	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	9	1.132438e-02	4
GO:CC	GO:0098590	plasma membrane region	"A membrane that is a (regional) part of the plasma membrane." [GOC:dos]	23	1.171941e-02	4
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	12	1.266622e-02	4
GO:CC	GO:0031252	cell leading edge	"The area of a motile cell closest to the direction of movement." [GOC:pg]	12	1.483022e-02	4
GO:CC	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060]	23	1.527631e-02	4
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	12	1.585165e-02	4
GO:CC	GO:1990565	HSP90-CDC37 chaperone complex	"A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." [GOC:bhm, GOC:pad, GOC:PARL, PMID:21855797, PMID:22939624]	2	1.662794e-02	4
GO:CC	GO:0034515	proteasome storage granule	"An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:krc, GOC:rb, PMID:18504300, PMID:30204036]	2	1.662794e-02	4
GO:CC	GO:0031588	nucleotide-activated protein kinase complex	"A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae)." [GOC:bhm, GOC:mah, GOC:vw]	3	1.761763e-02	4
GO:CC	GO:0097136	Bcl-2 family protein complex	"A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed." [GOC:so, PMID:14634621]	3	1.761763e-02	4
GO:CC	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	9	2.146295e-02	4
GO:CC	GO:0061695	transferase complex, transferring phosphorus-containing groups	"A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph]	10	2.808660e-02	4
GO:CC	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	4	3.279512e-02	4
GO:CC	GO:0043204	perikaryon	"The portion of the cell soma (neuronal cell body) that excludes the nucleus." [GOC:jl]	7	3.338627e-02	4
GO:CC	GO:0099522	cytosolic region	"Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos]	4	3.670105e-02	4
GO:CC	GO:0035253	ciliary rootlet	"A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867]	3	3.828954e-02	4
GO:CC	GO:0098793	presynapse	"The part of a synapse that is part of the presynaptic cell." [GOC:dos]	14	4.408246e-02	4
GO:CC	GO:0016507	mitochondrial fatty acid beta-oxidation multienzyme complex	"A multienzyme complex possessing three activities in two subunits (alpha and beta) that catalyzes three steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. The alpha subunit comprises the enoyl-CoA hydratase (ECH) and 3-hydroxyacyl-CoA dehydrogenase (HACD) activities, and the beta subunit contains the acetyl-CoA C-acyltransferase (KACT)/thiolase activity." [GOC:sjm, PMID:29915090]	2	4.966157e-02	4
GO:CC	GO:0036125	fatty acid beta-oxidation multienzyme complex	"A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT)." [GOC:imk, PMID:12115060, PMID:16472743]	2	4.966157e-02	4

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	101	5.242979e-29	4
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	62	7.729083e-24	4
GO:BP	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	70	7.323707e-20	4
GO:BP	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	64	2.455187e-19	4
GO:BP	GO:0006793	phosphorus metabolic process	"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]	64	2.626196e-19	4
GO:BP	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	47	3.554291e-19	4
GO:BP	GO:0043412	macromolecule modification	"The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]	71	5.139298e-19	4
GO:BP	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	48	1.008247e-18	4
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	41	1.180836e-16	4
GO:BP	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	67	1.205969e-16	4
GO:BP	GO:0008219	cell death	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]	55	1.570932e-16	4
GO:BP	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	54	8.172916e-16	4
GO:BP	GO:0031399	regulation of protein modification process	"Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	40	1.202124e-15	4
GO:BP	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	71	1.481839e-15	4
GO:BP	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	52	5.975356e-15	4
GO:BP	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	15	6.109004e-15	4
GO:BP	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	39	6.234625e-15	4
GO:BP	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	70	7.808579e-15	4
GO:BP	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	38	1.887472e-14	4
GO:BP	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	74	2.223774e-14	4
GO:BP	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	70	4.182484e-14	4
GO:BP	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	52	5.955952e-14	4
GO:BP	GO:0009056	catabolic process	"A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	59	1.085876e-13	4
GO:BP	GO:1901698	response to nitrogen compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	38	1.566493e-13	4
GO:BP	GO:0051084	'de novo' post-translational protein folding	"The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb]	12	2.239147e-13	4
GO:BP	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	56	2.738315e-13	4
GO:BP	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	23	3.684978e-13	4
GO:BP	GO:0048583	regulation of response to stimulus	"Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	72	7.496069e-13	4
GO:BP	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	62	9.102099e-13	4
GO:BP	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	12	9.867809e-13	4
GO:BP	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	34	1.396381e-12	4
GO:BP	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	112	1.413081e-12	4
GO:BP	GO:1902531	regulation of intracellular signal transduction	"Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	49	1.610624e-12	4
GO:BP	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	27	1.916038e-12	4
GO:BP	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	45	2.611188e-12	4
GO:BP	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	60	4.229554e-12	4
GO:BP	GO:0043067	regulation of programmed cell death	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	42	9.573344e-12	4
GO:BP	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	69	1.510569e-11	4
GO:BP	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	84	1.563123e-11	4
GO:BP	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	41	1.836033e-11	4
GO:BP	GO:0009408	response to heat	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]	14	2.256871e-11	4
GO:BP	GO:0061919	process utilizing autophagic mechanism	"A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378]	27	2.315835e-11	4
GO:BP	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	27	2.315835e-11	4
GO:BP	GO:1903829	positive regulation of protein localization	"Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	25	2.459309e-11	4
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	66	3.164783e-11	4
GO:BP	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	82	3.313960e-11	4
GO:BP	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	18	3.750596e-11	4
GO:BP	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	89	5.029660e-11	4
GO:BP	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	65	5.133931e-11	4
GO:BP	GO:0043069	negative regulation of programmed cell death	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	32	5.762007e-11	4
GO:BP	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	86	6.240539e-11	4
GO:BP	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	31	1.430303e-10	4
GO:BP	GO:0042325	regulation of phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]	30	2.365158e-10	4
GO:BP	GO:0019220	regulation of phosphate metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	32	2.575962e-10	4
GO:BP	GO:0023057	negative regulation of signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	39	2.647738e-10	4
GO:BP	GO:0051174	regulation of phosphorus metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]	32	2.650119e-10	4
GO:BP	GO:0010648	negative regulation of cell communication	"Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	39	2.706873e-10	4
GO:BP	GO:0001932	regulation of protein phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]	29	3.074616e-10	4
GO:BP	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	33	3.383143e-10	4
GO:BP	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	35	5.396918e-10	4
GO:BP	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	37	5.893479e-10	4
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	60	6.130444e-10	4
GO:BP	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	17	7.604241e-10	4
GO:BP	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	43	1.541486e-09	4
GO:BP	GO:0141124	intracellular signaling cassette	"An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg]	44	1.566159e-09	4
GO:BP	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	88	1.654496e-09	4
GO:BP	GO:0034605	cellular response to heat	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]	11	1.731720e-09	4
GO:BP	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	88	2.058945e-09	4
GO:BP	GO:0030162	regulation of proteolysis	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]	21	2.081018e-09	4
GO:BP	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	92	2.295697e-09	4
GO:BP	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	33	2.340159e-09	4
GO:BP	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	20	2.876728e-09	4
GO:BP	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	15	3.061912e-09	4
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	37	4.297025e-09	4
GO:BP	GO:0051234	establishment of localization	"Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]	74	4.433056e-09	4
GO:BP	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	94	4.735417e-09	4
GO:BP	GO:0051086	chaperone mediated protein folding independent of cofactor	"The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb]	6	5.460961e-09	4
GO:BP	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	83	5.486794e-09	4
GO:BP	GO:0009628	response to abiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]	33	6.001665e-09	4
GO:BP	GO:0018209	peptidyl-serine modification	"The modification of peptidyl-serine." [GOC:go_curators]	15	8.071771e-09	4
GO:BP	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	40	8.116191e-09	4
GO:BP	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	87	8.374958e-09	4
GO:BP	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	99	1.511547e-08	4
GO:BP	GO:1904874	positive regulation of telomerase RNA localization to Cajal body	"Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	6	1.628737e-08	4
GO:BP	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	48	2.101125e-08	4
GO:BP	GO:0009266	response to temperature stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb]	14	3.234510e-08	4
GO:BP	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	30	3.449333e-08	4
GO:BP	GO:0043254	regulation of protein-containing complex assembly	"Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl]	20	3.482582e-08	4
GO:BP	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	24	3.766211e-08	4
GO:BP	GO:0032870	cellular response to hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah]	24	3.890575e-08	4
GO:BP	GO:1904869	regulation of protein localization to Cajal body	"Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	6	4.048104e-08	4
GO:BP	GO:1904871	positive regulation of protein localization to Cajal body	"Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	6	4.048104e-08	4
GO:BP	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	78	4.767929e-08	4
GO:BP	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	24	4.875697e-08	4
GO:BP	GO:0023056	positive regulation of signaling	"Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	40	6.406983e-08	4
GO:BP	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	28	7.230591e-08	4
GO:BP	GO:0071840	cellular component organization or biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]	99	8.345472e-08	4
GO:BP	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	46	8.539500e-08	4
GO:BP	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	26	8.872949e-08	4
GO:BP	GO:0031400	negative regulation of protein modification process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	18	9.958313e-08	4
GO:BP	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	79	1.054015e-07	4
GO:BP	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	10	1.119716e-07	4
GO:BP	GO:1900182	positive regulation of protein localization to nucleus	"Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]	11	1.260422e-07	4
GO:BP	GO:0051248	negative regulation of protein metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]	24	1.319125e-07	4
GO:BP	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	29	1.330691e-07	4
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	42	1.348902e-07	4
GO:BP	GO:0038034	signal transduction in absence of ligand	"The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor." [GOC:al, GOC:ppm, GOC:pr, PMID:15044679]	10	1.495345e-07	4
GO:BP	GO:0070887	cellular response to chemical stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]	44	1.516930e-07	4
GO:BP	GO:0035966	response to topologically incorrect protein	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf]	13	1.633641e-07	4
GO:BP	GO:0018193	peptidyl-amino acid modification	"The alteration of an amino acid residue in a peptide." [GOC:mah]	24	1.727398e-07	4
GO:BP	GO:1903405	protein localization to nuclear body	"A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849]	6	1.760461e-07	4
GO:BP	GO:1904867	protein localization to Cajal body	"A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	6	1.760461e-07	4
GO:BP	GO:1904872	regulation of telomerase RNA localization to Cajal body	"Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	6	1.760461e-07	4
GO:BP	GO:0080134	regulation of response to stress	"Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	34	2.220622e-07	4
GO:BP	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	18	2.469066e-07	4
GO:BP	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	121	3.994680e-07	4
GO:BP	GO:0032212	positive regulation of telomere maintenance via telomerase	"Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]	7	4.200937e-07	4
GO:BP	GO:0007049	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]	37	4.390283e-07	4
GO:BP	GO:0051050	positive regulation of transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	26	4.476857e-07	4
GO:BP	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	21	4.745314e-07	4
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	23	5.075373e-07	4
GO:BP	GO:0010638	positive regulation of organelle organization	"Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]	20	5.513132e-07	4
GO:BP	GO:1990173	protein localization to nucleoplasm	"A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952]	6	5.655002e-07	4
GO:BP	GO:0043434	response to peptide hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]	19	5.786400e-07	4
GO:BP	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	65	6.236382e-07	4
GO:BP	GO:0097435	supramolecular fiber organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr]	26	6.359083e-07	4
GO:BP	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	23	6.412189e-07	4
GO:BP	GO:0051049	regulation of transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	36	6.779336e-07	4
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	49	7.445867e-07	4
GO:BP	GO:0071495	cellular response to endogenous stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]	31	7.653923e-07	4
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	49	8.649458e-07	4
GO:BP	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	125	8.899409e-07	4
GO:BP	GO:1900180	regulation of protein localization to nucleus	"Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]	12	9.645881e-07	4
GO:BP	GO:0010647	positive regulation of cell communication	"Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	38	9.755991e-07	4
GO:BP	GO:0009891	positive regulation of biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	48	9.778075e-07	4
GO:BP	GO:1904358	positive regulation of telomere maintenance via telomere lengthening	"Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]	7	1.058888e-06	4
GO:BP	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	7	1.058888e-06	4
GO:BP	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194]	26	1.349074e-06	4
GO:BP	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	49	1.364617e-06	4
GO:BP	GO:0009719	response to endogenous stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]	34	1.431844e-06	4
GO:BP	GO:0019941	modification-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]	22	1.482335e-06	4
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	16	1.544805e-06	4
GO:BP	GO:0032868	response to insulin	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	15	1.566241e-06	4
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	29	1.651779e-06	4
GO:BP	GO:0043632	modification-dependent macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl]	22	1.713682e-06	4
GO:BP	GO:0002682	regulation of immune system process	"Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]	35	1.730906e-06	4
GO:BP	GO:0097191	extrinsic apoptotic signaling pathway	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]	14	1.795242e-06	4
GO:BP	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	122	1.901335e-06	4
GO:BP	GO:0044419	biological process involved in interspecies interaction between organisms	"Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]	37	2.092049e-06	4
GO:BP	GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand	"Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]	8	2.258881e-06	4
GO:BP	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	31	2.305196e-06	4
GO:BP	GO:1903050	regulation of proteolysis involved in protein catabolic process	"Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]	14	2.509119e-06	4
GO:BP	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	19	2.727334e-06	4
GO:BP	GO:0009896	positive regulation of catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	20	3.336730e-06	4
GO:BP	GO:0046785	microtubule polymerization	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]	10	3.339282e-06	4
GO:BP	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	21	3.410813e-06	4
GO:BP	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	13	3.484967e-06	4
GO:BP	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	12	3.678657e-06	4
GO:BP	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	60	4.186435e-06	4
GO:BP	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	66	4.507352e-06	4
GO:BP	GO:0034097	response to cytokine	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl]	26	4.735865e-06	4
GO:BP	GO:0090671	telomerase RNA localization to Cajal body	"A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]	6	4.962155e-06	4
GO:BP	GO:0090685	RNA localization to nucleus	"A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931]	6	4.962155e-06	4
GO:BP	GO:0090672	telomerase RNA localization	"Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]	6	4.962155e-06	4
GO:BP	GO:0090670	RNA localization to Cajal body	"A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]	6	4.962155e-06	4
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]	20	5.138783e-06	4
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	20	5.138783e-06	4
GO:BP	GO:0032206	positive regulation of telomere maintenance	"Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]	9	5.139503e-06	4
GO:BP	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	33	5.390737e-06	4
GO:BP	GO:0042327	positive regulation of phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]	19	5.848946e-06	4
GO:BP	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	21	6.407486e-06	4
GO:BP	GO:1901652	response to peptide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]	26	6.562895e-06	4
GO:BP	GO:0031109	microtubule polymerization or depolymerization	"Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]	11	7.162640e-06	4
GO:BP	GO:0006986	response to unfolded protein	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]	11	8.340128e-06	4
GO:BP	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	37	8.632784e-06	4
GO:BP	GO:0045862	positive regulation of proteolysis	"Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]	13	9.325593e-06	4
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	"Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	45	9.448928e-06	4
GO:BP	GO:0009895	negative regulation of catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	16	1.090331e-05	4
GO:BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	17	1.113994e-05	4
GO:BP	GO:0016236	macroautophagy	"The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]	16	1.133905e-05	4
GO:BP	GO:1901099	negative regulation of signal transduction in absence of ligand	"Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand." [GOC:TermGenie]	7	1.157054e-05	4
GO:BP	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]	7	1.157054e-05	4
GO:BP	GO:0033043	regulation of organelle organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]	28	1.433830e-05	4
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	51	1.477224e-05	4
GO:BP	GO:0009607	response to biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]	34	1.530058e-05	4
GO:BP	GO:0070201	regulation of establishment of protein localization	"Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]	19	1.534251e-05	4
GO:BP	GO:0007004	telomere maintenance via telomerase	"The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh]	8	1.700676e-05	4
GO:BP	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	43	1.836830e-05	4
GO:BP	GO:0032200	telomere organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah]	12	2.065175e-05	4
GO:BP	GO:0051131	chaperone-mediated protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]	6	2.390765e-05	4
GO:BP	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	47	2.449296e-05	4
GO:BP	GO:0009314	response to radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]	17	2.475933e-05	4
GO:BP	GO:0006278	RNA-templated DNA biosynthetic process	"A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732]	8	2.528560e-05	4
GO:BP	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	47	2.588423e-05	4
GO:BP	GO:0051258	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	14	2.683495e-05	4
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	"Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	72	2.793916e-05	4
GO:BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	"Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	13	2.805360e-05	4
GO:BP	GO:0031396	regulation of protein ubiquitination	"Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	12	2.918553e-05	4
GO:BP	GO:0061136	regulation of proteasomal protein catabolic process	"Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb]	12	2.918553e-05	4
GO:BP	GO:0051707	response to other organism	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai]	33	2.925610e-05	4
GO:BP	GO:0030099	myeloid cell differentiation	"The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149]	17	3.024338e-05	4
GO:BP	GO:0043207	response to external biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators]	33	3.061986e-05	4
GO:BP	GO:1901873	regulation of post-translational protein modification	"Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]	13	3.587336e-05	4
GO:BP	GO:0009889	regulation of biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	73	3.948598e-05	4
GO:BP	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	32	4.042479e-05	4
GO:BP	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	27	4.400514e-05	4
GO:BP	GO:0032869	cellular response to insulin stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	12	5.061577e-05	4
GO:BP	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	18	5.275216e-05	4
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	30	5.326497e-05	4
GO:BP	GO:0030705	cytoskeleton-dependent intracellular transport	"The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]	12	5.630219e-05	4
GO:BP	GO:0032210	regulation of telomere maintenance via telomerase	"Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]	7	5.703356e-05	4
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]	14	6.301818e-05	4
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	14	6.301818e-05	4
GO:BP	GO:0043467	regulation of generation of precursor metabolites and energy	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl]	10	8.060884e-05	4
GO:BP	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]	10	8.060884e-05	4
GO:BP	GO:0010833	telomere maintenance via telomere lengthening	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb]	8	8.267691e-05	4
GO:BP	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	32	8.449550e-05	4
GO:BP	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	31	8.800087e-05	4
GO:BP	GO:0010001	glial cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]	13	9.077086e-05	4
GO:BP	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	24	9.537926e-05	4
GO:BP	GO:0002764	immune response-regulating signaling pathway	"The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]	18	9.608458e-05	4
GO:BP	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	26	9.772165e-05	4
GO:BP	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	78	9.967368e-05	4
GO:BP	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]	9	1.027028e-04	4
GO:BP	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	9	1.027028e-04	4
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	"Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	37	1.033902e-04	4
GO:BP	GO:0034504	protein localization to nucleus	"A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]	14	1.102518e-04	4
GO:BP	GO:2000573	positive regulation of DNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	7	1.197695e-04	4
GO:BP	GO:1903047	mitotic cell cycle process	"A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]	21	1.217531e-04	4
GO:BP	GO:0051085	chaperone cofactor-dependent protein refolding	"The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]	6	1.255452e-04	4
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	8	1.263686e-04	4
GO:BP	GO:0051656	establishment of organelle localization	"The directed movement of an organelle to a specific location." [GOC:ai]	17	1.343117e-04	4
GO:BP	GO:0032787	monocarboxylic acid metabolic process	"The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]	19	1.352360e-04	4
GO:BP	GO:0016241	regulation of macroautophagy	"Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc]	11	1.425951e-04	4
GO:BP	GO:0051640	organelle localization	"Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]	19	1.495827e-04	4
GO:BP	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	31	1.548807e-04	4
GO:BP	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	73	1.634093e-04	4
GO:BP	GO:0002253	activation of immune response	"Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]	18	1.656805e-04	4
GO:BP	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	24	1.671633e-04	4
GO:BP	GO:1904951	positive regulation of establishment of protein localization	"Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	14	1.677121e-04	4
GO:BP	GO:1902903	regulation of supramolecular fiber organization	"Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]	15	1.689721e-04	4
GO:BP	GO:0045913	positive regulation of carbohydrate metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]	8	1.709970e-04	4
GO:BP	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	12	1.771595e-04	4
GO:BP	GO:0032204	regulation of telomere maintenance	"Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]	9	1.800619e-04	4
GO:BP	GO:0034762	regulation of transmembrane transport	"Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]	16	1.874124e-04	4
GO:BP	GO:1904375	regulation of protein localization to cell periphery	"Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]	10	1.914163e-04	4
GO:BP	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	9	1.944738e-04	4
GO:BP	GO:1904356	regulation of telomere maintenance via telomere lengthening	"Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]	7	2.050211e-04	4
GO:BP	GO:0051129	negative regulation of cellular component organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	20	2.118415e-04	4
GO:BP	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	18	2.391795e-04	4
GO:BP	GO:0043276	anoikis	"Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, PMID:37667281]	6	2.703838e-04	4
GO:BP	GO:0032101	regulation of response to external stimulus	"Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	25	2.859876e-04	4
GO:BP	GO:2001236	regulation of extrinsic apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	10	2.945763e-04	4
GO:BP	GO:1905897	regulation of response to endoplasmic reticulum stress	"Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]	8	3.019977e-04	4
GO:BP	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	43	3.260045e-04	4
GO:BP	GO:0018210	peptidyl-threonine modification	"The modification of peptidyl-threonine." [GOC:go_curators]	8	3.306020e-04	4
GO:BP	GO:0051402	neuron apoptotic process	"Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis]	13	3.421360e-04	4
GO:BP	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	59	3.510413e-04	4
GO:BP	GO:0048869	cellular developmental process	"A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]	59	3.539049e-04	4
GO:BP	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	45	4.880223e-04	4
GO:BP	GO:0009185	ribonucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	9	4.961504e-04	4
GO:BP	GO:0032273	positive regulation of protein polymerization	"Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]	8	5.111564e-04	4
GO:BP	GO:0010507	negative regulation of autophagy	"Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	8	5.559403e-04	4
GO:BP	GO:0043470	regulation of carbohydrate catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg]	7	5.951037e-04	4
GO:BP	GO:0009154	purine ribonucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	9	6.064460e-04	4
GO:BP	GO:0007339	binding of sperm to zona pellucida	"The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437]	6	6.210132e-04	4
GO:BP	GO:0097193	intrinsic apoptotic signaling pathway	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]	13	6.243836e-04	4
GO:BP	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	10	6.554968e-04	4
GO:BP	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	8	6.556664e-04	4
GO:BP	GO:0045321	leukocyte activation	"A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add]	23	7.260707e-04	4
GO:BP	GO:0046032	ADP catabolic process	"The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators]	8	7.703261e-04	4
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	"Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]	8	7.703261e-04	4
GO:BP	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	10	7.704941e-04	4
GO:BP	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	23	7.794564e-04	4
GO:BP	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	22	7.827781e-04	4
GO:BP	GO:0009132	nucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	9	7.862165e-04	4
GO:BP	GO:0034330	cell junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]	21	7.891132e-04	4
GO:BP	GO:0002757	immune response-activating signaling pathway	"The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add]	16	8.106020e-04	4
GO:BP	GO:0021782	glial cell development	"The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	9	8.377850e-04	4
GO:BP	GO:0006109	regulation of carbohydrate metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators]	10	8.566435e-04	4
GO:BP	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	15	8.617761e-04	4
GO:BP	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	8	9.017244e-04	4
GO:BP	GO:0019364	pyridine nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw]	8	9.017244e-04	4
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	"Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	54	9.059973e-04	4
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	34	9.229470e-04	4
GO:BP	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	17	9.242414e-04	4
GO:BP	GO:0009416	response to light stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]	13	9.246888e-04	4
GO:BP	GO:0045595	regulation of cell differentiation	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]	30	9.365476e-04	4
GO:BP	GO:0009261	ribonucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	9	9.497787e-04	4
GO:BP	GO:2001233	regulation of apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	14	9.627189e-04	4
GO:BP	GO:0009181	purine ribonucleoside diphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	9.743098e-04	4
GO:BP	GO:0009137	purine nucleoside diphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	9.743098e-04	4
GO:BP	GO:0010970	transport along microtubule	"The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb]	10	1.001681e-03	4
GO:BP	GO:0060284	regulation of cell development	"Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]	21	1.014253e-03	4
GO:BP	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]	116	1.038268e-03	4
GO:BP	GO:0006195	purine nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	9	1.074519e-03	4
GO:BP	GO:0044089	positive regulation of cellular component biogenesis	"Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	16	1.084824e-03	4
GO:BP	GO:0072526	pyridine-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]	8	1.134567e-03	4
GO:BP	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	28	1.165920e-03	4
GO:BP	GO:0022411	cellular component disassembly	"A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete]	15	1.179956e-03	4
GO:BP	GO:0009191	ribonucleoside diphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	1.222799e-03	4
GO:BP	GO:0046031	ADP metabolic process	"The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators]	8	1.316827e-03	4
GO:BP	GO:0050804	modulation of chemical synaptic transmission	"Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai]	16	1.334291e-03	4
GO:BP	GO:0070841	inclusion body assembly	"The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah]	5	1.365068e-03	4
GO:BP	GO:0099177	regulation of trans-synaptic signaling	"Any process that modulates the frequency, rate or extent of trans-synaptic signaling." [GOC:dos]	16	1.368873e-03	4
GO:BP	GO:0022414	reproductive process	"A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]	30	1.427617e-03	4
GO:BP	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	35	1.451406e-03	4
GO:BP	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	32	1.505718e-03	4
GO:BP	GO:0009134	nucleoside diphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	1.636854e-03	4
GO:BP	GO:0010827	regulation of D-glucose transmembrane transport	"Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	7	1.781754e-03	4
GO:BP	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	20	1.945591e-03	4
GO:BP	GO:0051054	positive regulation of DNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]	12	1.996331e-03	4
GO:BP	GO:0046649	lymphocyte activation	"A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]	20	2.221898e-03	4
GO:BP	GO:0033365	protein localization to organelle	"A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]	25	2.226158e-03	4
GO:BP	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	40	2.284719e-03	4
GO:BP	GO:0042063	gliogenesis	"The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid]	13	2.421827e-03	4
GO:BP	GO:0032271	regulation of protein polymerization	"Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]	10	2.767987e-03	4
GO:BP	GO:0072523	purine-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	9	2.844192e-03	4
GO:BP	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	113	2.913554e-03	4
GO:BP	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	80	2.961388e-03	4
GO:BP	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	30	3.008138e-03	4
GO:BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	3.023774e-03	4
GO:BP	GO:0009135	purine nucleoside diphosphate metabolic process	"The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	8	3.023774e-03	4
GO:BP	GO:0034764	positive regulation of transmembrane transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]	10	3.168208e-03	4
GO:BP	GO:0050778	positive regulation of immune response	"Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	19	3.253174e-03	4
GO:BP	GO:0035036	sperm-egg recognition	"The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf]	6	3.443260e-03	4
GO:BP	GO:0044092	negative regulation of molecular function	"Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]	16	3.544831e-03	4
GO:BP	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	12	3.606630e-03	4
GO:BP	GO:0000902	cell morphogenesis	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]	22	3.623301e-03	4
GO:BP	GO:0050807	regulation of synapse organization	"Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]	12	3.729752e-03	4
GO:BP	GO:0033121	regulation of purine nucleotide catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah]	6	3.851168e-03	4
GO:BP	GO:0030811	regulation of nucleotide catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]	6	3.851168e-03	4
GO:BP	GO:0006110	regulation of glycolytic process	"Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators]	6	3.851168e-03	4
GO:BP	GO:0140546	defense response to symbiont	"Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg]	23	3.951444e-03	4
GO:BP	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	11	3.955503e-03	4
GO:BP	GO:0009166	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	9	4.101207e-03	4
GO:BP	GO:0051651	maintenance of location in cell	"Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]	10	4.122262e-03	4
GO:BP	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	16	4.263702e-03	4
GO:BP	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	10	4.303442e-03	4
GO:BP	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	19	4.328355e-03	4
GO:BP	GO:0098916	anterograde trans-synaptic signaling	"Cell-cell signaling from pre to post-synapse, across the synaptic cleft." [GOC:dos]	19	4.328355e-03	4
GO:BP	GO:0040007	growth	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]	21	4.419230e-03	4
GO:BP	GO:0042326	negative regulation of phosphorylation	"Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl]	11	4.424739e-03	4
GO:BP	GO:0009199	ribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	11	4.424739e-03	4
GO:BP	GO:0050803	regulation of synapse structure or activity	"Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]	12	4.700720e-03	4
GO:BP	GO:0099537	trans-synaptic signaling	"Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos]	19	4.842085e-03	4
GO:BP	GO:0098542	defense response to other organism	"Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]	25	4.868464e-03	4
GO:BP	GO:0008286	insulin receptor signaling pathway	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]	8	4.996021e-03	4
GO:BP	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	8	4.996021e-03	4
GO:BP	GO:0051098	regulation of binding	"Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]	10	5.099281e-03	4
GO:BP	GO:0031929	TOR signaling	"The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]	9	5.268745e-03	4
GO:BP	GO:0035295	tube development	"The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]	23	5.286377e-03	4
GO:BP	GO:0006954	inflammatory response	"The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732]	20	5.308493e-03	4
GO:BP	GO:0062012	regulation of small molecule metabolic process	"Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]	12	5.350406e-03	4
GO:BP	GO:0061684	chaperone-mediated autophagy	"The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded." [GOC:pad, GOC:PARL, PMID:22743996, PMID:23434281]	4	5.364283e-03	4
GO:BP	GO:0050673	epithelial cell proliferation	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544]	14	5.536387e-03	4
GO:BP	GO:0008152	metabolic process	"A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	125	5.561612e-03	4
GO:BP	GO:0090666	scaRNA localization to Cajal body	"A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]	3	5.951057e-03	4
GO:BP	GO:0009566	fertilization	"The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732]	10	6.020091e-03	4
GO:BP	GO:0072384	organelle transport along microtubule	"The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]	7	6.138555e-03	4
GO:BP	GO:0051235	maintenance of location	"Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]	10	6.271679e-03	4
GO:BP	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	11	6.360380e-03	4
GO:BP	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	9	6.711542e-03	4
GO:BP	GO:0099111	microtubule-based transport	"A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	10	6.802373e-03	4
GO:BP	GO:2000278	regulation of DNA biosynthetic process	"Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	7	7.113314e-03	4
GO:BP	GO:0048167	regulation of synaptic plasticity	"A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]	10	7.671426e-03	4
GO:BP	GO:0044093	positive regulation of molecular function	"Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]	20	7.742582e-03	4
GO:BP	GO:0009141	nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	11	7.847660e-03	4
GO:BP	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	46	7.950423e-03	4
GO:BP	GO:0097305	response to alcohol	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [GOC:pr, PMID:24014527]	11	8.123051e-03	4
GO:BP	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	20	8.143355e-03	4
GO:BP	GO:1902905	positive regulation of supramolecular fiber organization	"Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]	9	8.481510e-03	4
GO:BP	GO:0046326	positive regulation of D-glucose import	"Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai, GOC:dph, GOC:tb]	5	9.096693e-03	4
GO:BP	GO:0046034	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	10	9.702266e-03	4
GO:BP	GO:0000165	MAPK cascade	"An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]	18	9.752700e-03	4
GO:BP	GO:0044843	cell cycle G1/S phase transition	"The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle]	10	1.008246e-02	4
GO:BP	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	43	1.050066e-02	4
GO:BP	GO:0048871	multicellular organismal-level homeostasis	"Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete]	19	1.065181e-02	4
GO:BP	GO:0040008	regulation of growth	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]	16	1.088655e-02	4
GO:BP	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	29	1.109084e-02	4
GO:BP	GO:0043436	oxoacid metabolic process	"The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid]	20	1.170731e-02	4
GO:BP	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	10	1.173528e-02	4
GO:BP	GO:1901292	nucleoside phosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie]	9	1.214496e-02	4
GO:BP	GO:0006082	organic acid metabolic process	"The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]	20	1.289841e-02	4
GO:BP	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	64	1.333147e-02	4
GO:BP	GO:1905898	positive regulation of response to endoplasmic reticulum stress	"Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]	5	1.365721e-02	4
GO:BP	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	25	1.406469e-02	4
GO:BP	GO:0051094	positive regulation of developmental process	"Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	25	1.424635e-02	4
GO:BP	GO:0002573	myeloid leukocyte differentiation	"The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251]	10	1.465293e-02	4
GO:BP	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	22	1.466881e-02	4
GO:BP	GO:0008637	apoptotic mitochondrial changes	"The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis]	7	1.507734e-02	4
GO:BP	GO:0033044	regulation of chromosome organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]	10	1.575559e-02	4
GO:BP	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	57	1.577159e-02	4
GO:BP	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	20	1.586347e-02	4
GO:BP	GO:0062013	positive regulation of small molecule metabolic process	"Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]	8	1.594649e-02	4
GO:BP	GO:0016049	cell growth	"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]	14	1.637581e-02	4
GO:BP	GO:1905475	regulation of protein localization to membrane	"Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]	9	1.708742e-02	4
GO:BP	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	7	1.711704e-02	4
GO:BP	GO:0001933	negative regulation of protein phosphorylation	"Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	10	1.754382e-02	4
GO:BP	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	32	1.779724e-02	4
GO:BP	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	10	1.817759e-02	4
GO:BP	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	15	1.851273e-02	4
GO:BP	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	13	1.876595e-02	4
GO:BP	GO:0042592	homeostatic process	"Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172]	29	1.962750e-02	4
GO:BP	GO:0050678	regulation of epithelial cell proliferation	"Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai]	12	1.974490e-02	4
GO:BP	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	5	1.983614e-02	4
GO:BP	GO:0072521	purine-containing compound metabolic process	"The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	15	2.013738e-02	4
GO:BP	GO:1990778	protein localization to cell periphery	"A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290]	12	2.029318e-02	4
GO:BP	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	21	2.061073e-02	4
GO:BP	GO:0002521	leukocyte differentiation	"The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264]	16	2.070299e-02	4
GO:BP	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	32	2.112084e-02	4
GO:BP	GO:0001503	ossification	"The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649]	13	2.124326e-02	4
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	23	2.131536e-02	4
GO:BP	GO:0035967	cellular response to topologically incorrect protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf]	7	2.188628e-02	4
GO:BP	GO:0071364	cellular response to epidermal growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah]	5	2.231863e-02	4
GO:BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	10	2.319375e-02	4
GO:BP	GO:0070555	response to interleukin-1	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:BHF, GOC:mah]	7	2.323635e-02	4
GO:BP	GO:0032103	positive regulation of response to external stimulus	"Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah]	16	2.324371e-02	4
GO:BP	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	13	2.342801e-02	4
GO:BP	GO:0009259	ribonucleotide metabolic process	"The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	12	2.451881e-02	4
GO:BP	GO:1903578	regulation of ATP metabolic process	"Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849]	6	2.458828e-02	4
GO:BP	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	9	2.461181e-02	4
GO:BP	GO:0010828	positive regulation of D-glucose transmembrane transport	"Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb]	5	2.503695e-02	4
GO:BP	GO:0006753	nucleoside phosphate metabolic process	"The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah]	16	2.508845e-02	4
GO:BP	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	19	2.599588e-02	4
GO:BP	GO:0009988	cell-cell recognition	"Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820]	6	2.657145e-02	4
GO:BP	GO:0051222	positive regulation of protein transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	10	2.746920e-02	4
GO:BP	GO:0051223	regulation of protein transport	"Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	13	2.839835e-02	4
GO:BP	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	29	2.860416e-02	4
GO:BP	GO:1904377	positive regulation of protein localization to cell periphery	"Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]	6	2.868178e-02	4
GO:BP	GO:0007051	spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah]	9	2.876976e-02	4
GO:BP	GO:0009144	purine nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	10	2.936023e-02	4
GO:BP	GO:0031347	regulation of defense response	"Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah]	18	3.025980e-02	4
GO:BP	GO:0019693	ribose phosphate metabolic process	"The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]	12	3.027336e-02	4
GO:BP	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	12	3.027336e-02	4
GO:BP	GO:0030010	establishment of cell polarity	"The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	8	3.121565e-02	4
GO:BP	GO:0141156	cAMP/PKA signal transduction	"An intracellular signaling cassette that starts with production of cyclic AMP (cAMP) by adenylate cyclase (either transmembrane or soluble), which activates protein kinase A, and ends with activation of downstream effectors such as the transcription factor CREB that further transmit the signal within the cell." [PMID:23209152]	3	3.280836e-02	4
GO:BP	GO:2000147	positive regulation of cell motility	"Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah]	15	3.283021e-02	4
GO:BP	GO:0046822	regulation of nucleocytoplasmic transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]	7	3.286486e-02	4
GO:BP	GO:1904659	D-glucose transmembrane transport	"The process in which D-glucose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050]	7	3.286486e-02	4
GO:BP	GO:0007006	mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	7	3.286486e-02	4
GO:BP	GO:0090042	tubulin deacetylation	"The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:BHF, GOC:dph, GOC:tb]	4	3.329639e-02	4
GO:BP	GO:0051090	regulation of DNA-binding transcription factor activity	"Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	11	3.337102e-02	4
GO:BP	GO:0032386	regulation of intracellular transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	10	3.572070e-02	4
GO:BP	GO:0046496	nicotinamide nucleotide metabolic process	"The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732]	8	3.572987e-02	4
GO:BP	GO:0019362	pyridine nucleotide metabolic process	"The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl]	8	3.572987e-02	4
GO:BP	GO:0040012	regulation of locomotion	"Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]	21	3.643548e-02	4
GO:BP	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	18	3.678968e-02	4
GO:BP	GO:0070849	response to epidermal growth factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:BHF, GOC:mah]	5	3.858652e-02	4
GO:BP	GO:0008645	hexose transmembrane transport	"The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule." [GOC:vw]	7	3.879165e-02	4
GO:BP	GO:0044085	cellular component biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]	58	3.947805e-02	4
GO:BP	GO:0042391	regulation of membrane potential	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]	13	4.118814e-02	4
GO:BP	GO:0055086	nucleobase-containing small molecule metabolic process	"The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw]	16	4.134087e-02	4
GO:BP	GO:0019637	organophosphate metabolic process	"The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]	21	4.181063e-02	4
GO:BP	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	11	4.421630e-02	4
GO:BP	GO:0040017	positive regulation of locomotion	"Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]	15	4.482517e-02	4
GO:BP	GO:0015749	monosaccharide transmembrane transport	"The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GO_REF:0000069, GOC:TermGenie, GOC:vw]	7	4.557330e-02	4
GO:BP	GO:0044770	cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle]	14	4.575574e-02	4
GO:BP	GO:0006913	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	11	4.671756e-02	4
GO:BP	GO:0051169	nuclear transport	"The directed movement of substances into, out of, or within the nucleus." [GOC:ai]	11	4.671756e-02	4
GO:BP	GO:0030220	platelet formation	"The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194]	4	4.704475e-02	4
GO:BP	GO:0035601	protein deacylation	"The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid." [GOC:se, PMID:12080046]	5	4.720540e-02	4
GO:BP	GO:1903131	mononuclear cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906]	14	4.767482e-02	4
GO:BP	GO:0072655	establishment of protein localization to mitochondrion	"The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah]	7	4.803969e-02	4
GO:BP	GO:0072524	pyridine-containing compound metabolic process	"The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]	8	4.843300e-02	4
GO:BP	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	25	4.854703e-02	4
GO:BP	GO:0030030	cell projection organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917]	27	4.879248e-02	4

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	61	5.325518e-25	4
GO:MF	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	58	1.240703e-23	4
GO:MF	GO:0017076	purine nucleotide binding	"Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]	67	9.687344e-23	4
GO:MF	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	15	1.083874e-21	4
GO:MF	GO:1901265	nucleoside phosphate binding	"Binding to nucleoside phosphate." [GOC:TermGenie]	68	1.409616e-21	4
GO:MF	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	55	1.418797e-21	4
GO:MF	GO:0032555	purine ribonucleotide binding	"Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	64	2.469545e-21	4
GO:MF	GO:0032553	ribonucleotide binding	"Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	64	3.807372e-21	4
GO:MF	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	67	5.717486e-21	4
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	63	5.725843e-21	4
GO:MF	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	68	3.131547e-20	4
GO:MF	GO:0035639	purine ribonucleoside triphosphate binding	"Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732]	61	1.371029e-19	4
GO:MF	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	66	6.426167e-19	4
GO:MF	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	67	2.715078e-18	4
GO:MF	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	107	2.797167e-18	4
GO:MF	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	25	3.018707e-16	4
GO:MF	GO:0044389	ubiquitin-like protein ligase binding	"Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]	25	1.197413e-15	4
GO:MF	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	15	1.268224e-15	4
GO:MF	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	35	3.986089e-15	4
GO:MF	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	64	8.095772e-15	4
GO:MF	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	38	2.304042e-14	4
GO:MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-]	36	4.605937e-14	4
GO:MF	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925]	29	7.179967e-14	4
GO:MF	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	17	8.104228e-14	4
GO:MF	GO:0106310	protein serine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989]	24	1.734159e-13	4
GO:MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	39	7.660322e-13	4
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	147	1.409880e-12	4
GO:MF	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	29	4.964550e-11	4
GO:MF	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	14	8.719418e-11	4
GO:MF	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	30	1.079300e-10	4
GO:MF	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	26	1.770154e-09	4
GO:MF	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-]	52	3.444176e-09	4
GO:MF	GO:0036094	small molecule binding	"Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]	89	8.373843e-09	4
GO:MF	GO:0048156	tau protein binding	"Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]	9	1.766482e-08	4
GO:MF	GO:0043167	ion binding	"Binding to an ion, a charged atoms or groups of atoms." [GOC:jl]	86	3.751239e-08	4
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	17	3.782091e-07	4
GO:MF	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	22	1.011127e-06	4
GO:MF	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	42	2.826227e-06	4
GO:MF	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	17	8.193500e-06	4
GO:MF	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	19	2.897534e-05	4
GO:MF	GO:0098772	molecular function regulator activity	"A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt]	40	3.457956e-05	4
GO:MF	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	10	4.509398e-05	4
GO:MF	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	5	6.278933e-05	4
GO:MF	GO:0004691	cAMP-dependent protein kinase activity	"cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [PMID:32935175, PMID:35053423, PMID:35805104]	5	8.842130e-05	4
GO:MF	GO:0004690	cyclic nucleotide-dependent protein kinase activity	"cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]	5	1.641797e-04	4
GO:MF	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	49	2.753171e-04	4
GO:MF	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	20	3.558270e-04	4
GO:MF	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	25	5.860375e-04	4
GO:MF	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	6	6.155808e-04	4
GO:MF	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	26	6.531789e-04	4
GO:MF	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	27	8.940332e-04	4
GO:MF	GO:0051400	BH domain binding	"Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409]	4	1.006012e-03	4
GO:MF	GO:0097718	disordered domain specific binding	"Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698]	5	1.579522e-03	4
GO:MF	GO:0017111	ribonucleoside triphosphate phosphatase activity	"Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680]	25	1.875232e-03	4
GO:MF	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	22	3.434083e-03	4
GO:MF	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	25	4.419703e-03	4
GO:MF	GO:0016817	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	25	4.481020e-03	4
GO:MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	25	4.481020e-03	4
GO:MF	GO:0051434	BH3 domain binding	"Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259]	3	5.767186e-03	4
GO:MF	GO:0030911	TPR domain binding	"Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah]	3	1.003766e-02	4
GO:MF	GO:0030235	nitric-oxide synthase regulator activity	"Binds to and modulates the activity of nitric oxide synthase." [GOC:mah]	3	1.003766e-02	4
GO:MF	GO:0004712	protein serine/threonine/tyrosine kinase activity	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]	5	1.177772e-02	4
GO:MF	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	149	1.399327e-02	4
GO:MF	GO:0004679	AMP-activated protein kinase activity	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP." [GOC:mah]	3	1.597290e-02	4
GO:MF	GO:0030674	protein-macromolecule adaptor activity	"An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	21	1.885369e-02	4
GO:MF	GO:0023026	MHC class II protein complex binding	"Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw]	4	2.015079e-02	4
GO:MF	GO:0019210	kinase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a kinase." [GOC:mah]	6	2.104867e-02	4
GO:MF	GO:0016247	channel regulator activity	"Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah]	8	2.381494e-02	4
GO:MF	GO:0035173	histone kinase activity	"Catalysis of the transfer of a phosphate group to a histone." [GOC:bf]	4	2.385118e-02	4
GO:MF	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	5	2.486543e-02	4
GO:MF	GO:0141108	transporter regulator activity	"Binds to and modulates the activity of a transporter." [GOC:curators]	8	2.595503e-02	4
GO:MF	GO:0004709	MAP kinase kinase kinase activity	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]	4	2.802581e-02	4
GO:MF	GO:0140678	molecular function inhibitor activity	"A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	14	2.912951e-02	4
GO:MF	GO:0019207	kinase regulator activity	"Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai]	10	3.223351e-02	4
GO:MF	GO:0004517	nitric-oxide synthase activity	"Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, RHEA:19897]	3	3.385650e-02	4
GO:MF	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	12	3.525176e-02	4
GO:MF	GO:0015459	potassium channel regulator activity	"Binds to and modulates the activity of a potassium channel." [GOC:dos, GOC:mah]	5	3.962958e-02	4
GO:MF	GO:0035403	histone H3T6 kinase activity	"Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3." [GOC:bf]	2	4.009420e-02	4

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5426	HDAC6 interactions in the central nervous system	HDAC6 interactions in the central nervous system	22	5.537278e-17	4
WP	WP:WP2359	Parkin ubiquitin proteasomal system pathway	Parkin ubiquitin proteasomal system pathway	18	9.277523e-16	4
WP	WP:WP481	Insulin signaling	Insulin signaling	22	1.611844e-13	4
WP	WP:WP3965	Lipid metabolism pathway	Lipid metabolism pathway	11	2.434429e-11	4
WP	WP:WP382	MAPK signaling	MAPK signaling	23	1.444581e-10	4
WP	WP:WP4566	Translation inhibitors in chronically activated PDGFRA cells	Translation inhibitors in chronically activated PDGFRA cells	12	3.009247e-10	4
WP	WP:WP5124	Alzheimer 39 s disease	Alzheimer 39 s disease	23	5.055441e-10	4
WP	WP:WP2059	Alzheimer 39 s disease and miRNA effects	Alzheimer 39 s disease and miRNA effects	23	7.529654e-10	4
WP	WP:WP2795	Cardiac hypertrophic response	Cardiac hypertrophic response	11	4.946122e-08	4
WP	WP:WP3915	Angiopoietin like protein 8 regulatory pathway	Angiopoietin like protein 8 regulatory pathway	15	1.378823e-07	4
WP	WP:WP3872	Apoptosis regulation by parathyroid hormone related protein	Apoptosis regulation by parathyroid hormone related protein	8	2.106507e-07	4
WP	WP:WP4806	EGFR tyrosine kinase inhibitor resistance	EGFR tyrosine kinase inhibitor resistance	12	5.466367e-07	4
WP	WP:WP35	G protein signaling	G protein signaling	12	1.079608e-06	4
WP	WP:WP437	EGF EGFR signaling	EGF EGFR signaling	15	1.710052e-06	4
WP	WP:WP4223	Ras signaling	Ras signaling	16	1.738876e-06	4
WP	WP:WP2380	Brain derived neurotrophic factor BDNF signaling	Brain derived neurotrophic factor BDNF signaling	14	2.145482e-06	4
WP	WP:WP4172	PI3K Akt signaling	PI3K Akt signaling	21	3.002010e-06	4
WP	WP:WP2261	Glioblastoma signaling	Glioblastoma signaling	11	5.119346e-06	4
WP	WP:WP5441	Artemisinin inhibition of uveal melanoma	Artemisinin inhibition of uveal melanoma	4	9.059740e-06	4
WP	WP:WP231	TNF alpha signaling	TNF alpha signaling	11	1.224528e-05	4
WP	WP:WP195	IL1 signaling	IL1 signaling	9	1.461241e-05	4
WP	WP:WP5372	Involvement of secretase in neurodegenerative diseases	Involvement of secretase in neurodegenerative diseases	6	1.958107e-05	4
WP	WP:WP3888	VEGFA VEGFR2 signaling	VEGFA VEGFR2 signaling	22	4.688784e-05	4
WP	WP:WP5531	AKT signaling and ARTD family members	AKT signaling and ARTD family members	7	9.757227e-05	4
WP	WP:WP1403	AMP activated protein kinase signaling	AMP activated protein kinase signaling	9	1.001171e-04	4
WP	WP:WP5094	Orexin receptor pathway	Orexin receptor pathway	10	1.121920e-04	4
WP	WP:WP5293	Acute myeloid leukemia	Acute myeloid leukemia	9	1.139782e-04	4
WP	WP:WP673	ErbB signaling	ErbB signaling	10	1.248435e-04	4
WP	WP:WP4659	Gastrin signaling	Gastrin signaling	11	1.584156e-04	4
WP	WP:WP3929	Chemokine signaling	Chemokine signaling	13	1.591676e-04	4
WP	WP:WP2035	Follicle stimulating hormone FSH signaling	Follicle stimulating hormone FSH signaling	6	1.957949e-04	4
WP	WP:WP5215	Targeted agents in triple negative breast cancer	Targeted agents in triple negative breast cancer	7	2.180438e-04	4
WP	WP:WP4540	Hippo signaling regulation	Hippo signaling regulation	10	3.077156e-04	4
WP	WP:WP3873	RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis	RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis	5	3.428056e-04	4
WP	WP:WP3932	Focal adhesion PI3K Akt mTOR signaling	Focal adhesion PI3K Akt mTOR signaling	17	3.540791e-04	4
WP	WP:WP2636	Common pathways underlying drug addiction	Common pathways underlying drug addiction	7	3.745336e-04	4
WP	WP:WP4666	Hepatitis B infection	Hepatitis B infection	12	4.245531e-04	4
WP	WP:WP289	Myometrial relaxation and contraction pathways	Myometrial relaxation and contraction pathways	12	4.874125e-04	4
WP	WP:WP1544	MicroRNAs in cardiomyocyte hypertrophy	MicroRNAs in cardiomyocyte hypertrophy	10	5.325476e-04	4
WP	WP:WP244	Alpha 6 beta 4 signaling	Alpha 6 beta 4 signaling	6	1.446407e-03	4
WP	WP:WP2018	RANKL RANK signaling	RANKL RANK signaling	7	1.491870e-03	4
WP	WP:WP4539	Synaptic signaling associated with autism spectrum disorder	Synaptic signaling associated with autism spectrum disorder	7	1.491870e-03	4
WP	WP:WP5470	Effect of omega 3 PUFA on Huntington 39 s disease pathways	Effect of omega 3 PUFA on Huntington 39 s disease pathways	10	1.944079e-03	4
WP	WP:WP4549	Fragile X syndrome	Fragile X syndrome	10	2.093250e-03	4
WP	WP:WP4674	Head and neck squamous cell carcinoma	Head and neck squamous cell carcinoma	8	2.340364e-03	4
WP	WP:WP536	Calcium regulation in cardiac cells	Calcium regulation in cardiac cells	11	2.348770e-03	4
WP	WP:WP5434	Cancer pathways	Cancer pathways	21	2.489241e-03	4
WP	WP:WP5294	Sildenafil treatment	Sildenafil treatment	5	2.768793e-03	4
WP	WP:WP4949	16p11 2 proximal deletion syndrome	16p11 2 proximal deletion syndrome	8	2.857324e-03	4
WP	WP:WP2374	Oncostatin M signaling	Oncostatin M signaling	7	3.220906e-03	4
WP	WP:WP3879	4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression	4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression	5	5.392933e-03	4
WP	WP:WP2436	Dopamine metabolism	Dopamine metabolism	4	5.846753e-03	4
WP	WP:WP183	Proteasome degradation	Proteasome degradation	7	6.351321e-03	4
WP	WP:WP306	Focal adhesion	Focal adhesion	12	6.376770e-03	4
WP	WP:WP4018	Clear cell renal cell carcinoma pathways	Clear cell renal cell carcinoma pathways	8	6.533301e-03	4
WP	WP:WP4155	Endometrial cancer	Endometrial cancer	7	7.059239e-03	4
WP	WP:WP5098	T cell activation SARS CoV 2	T cell activation SARS CoV 2	8	8.412282e-03	4
WP	WP:WP4263	Pancreatic adenocarcinoma pathway	Pancreatic adenocarcinoma pathway	8	8.412282e-03	4
WP	WP:WP2355	Corticotropin releasing hormone signaling	Corticotropin releasing hormone signaling	8	1.072278e-02	4
WP	WP:WP3878	ATM signaling in development and disease	ATM signaling in development and disease	6	1.186028e-02	4
WP	WP:WP1982	Sterol regulatory element binding proteins SREBP signaling	Sterol regulatory element binding proteins SREBP signaling	7	1.280153e-02	4
WP	WP:WP2038	Microtubule cytoskeleton regulation	Microtubule cytoskeleton regulation	6	1.339364e-02	4
WP	WP:WP4941	GPR143 in melanocytes and retinal pigment epithelium cells	GPR143 in melanocytes and retinal pigment epithelium cells	5	1.364157e-02	4
WP	WP:WP4658	Small cell lung cancer	Small cell lung cancer	8	1.460546e-02	4
WP	WP:WP2034	Leptin signaling	Leptin signaling	7	1.540246e-02	4
WP	WP:WP5420	ADHD and autism ASD pathways	ADHD and autism ASD pathways	16	1.579255e-02	4
WP	WP:WP4255	Non small cell lung cancer	Non small cell lung cancer	7	1.685608e-02	4
WP	WP:WP3611	Photodynamic therapy induced AP 1 survival signaling	Photodynamic therapy induced AP 1 survival signaling	6	1.693442e-02	4
WP	WP:WP3844	PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer	PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer	5	1.883072e-02	4
WP	WP:WP69	T cell receptor signaling	T cell receptor signaling	7	2.190234e-02	4
WP	WP:WP5344	Cardiomyocyte signaling converging on titin	Cardiomyocyte signaling converging on titin	5	2.193506e-02	4
WP	WP:WP5490	Inhibition of GNAQ regulated signaling in uveal melanoma	Inhibition of GNAQ regulated signaling in uveal melanoma	5	2.193506e-02	4
WP	WP:WP304	Kit receptor signaling	Kit receptor signaling	6	2.360471e-02	4
WP	WP:WP3859	TGF beta signaling in thyroid cells for epithelial mesenchymal transition	TGF beta signaling in thyroid cells for epithelial mesenchymal transition	4	2.960801e-02	4
WP	WP:WP4754	IL18 signaling	IL18 signaling	6	3.221009e-02	4
WP	WP:WP4630	Measles virus infection	Measles virus infection	9	3.357630e-02	4
WP	WP:WP1471	Target of rapamycin signaling	Target of rapamycin signaling	5	3.364060e-02	4
WP	WP:WP5440	EPAC1 and PKA reduction of retinal inflammation	EPAC1 and PKA reduction of retinal inflammation	3	3.365022e-02	4
WP	WP:WP3614	Photodynamic therapy induced HIF 1 survival signaling	Photodynamic therapy induced HIF 1 survival signaling	5	3.844475e-02	4
WP	WP:WP2032	Thyroid stimulating hormone TSH signaling	Thyroid stimulating hormone TSH signaling	6	3.920699e-02	4
WP	WP:WP4205	MET in type 1 papillary renal cell carcinoma	MET in type 1 papillary renal cell carcinoma	6	3.920699e-02	4
WP	WP:WP5497	Cyclin dependent kinase 4 6 inhibitors in breast cancer	Cyclin dependent kinase 4 6 inhibitors in breast cancer	5	4.375520e-02	4
WP	WP:WP2366	Butyrate induced histone acetylation	Butyrate induced histone acetylation	2	4.403537e-02	4
WP	WP:WP5437	GNAQ pathways in port wine stain	GNAQ pathways in port wine stain	4	4.469350e-02	4
WP	WP:WP4864	Host pathogen interaction of human coronaviruses apoptosis	Host pathogen interaction of human coronaviruses apoptosis	4	4.469350e-02	4
WP	WP:WP1602	Nicotine effect on dopaminergic neurons	Nicotine effect on dopaminergic neurons	4	4.469350e-02	4
WP	WP:WP2263	Androgen receptor network in prostate cancer	Androgen receptor network in prostate cancer	8	4.937324e-02	4
WP	WP:WP4871	Kisspeptin kisspeptin receptor system in the ovary	Kisspeptin kisspeptin receptor system in the ovary	5	4.960663e-02	4

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-168256	Immune System	Immune System	70	2.749619e-16	4
REAC	REAC:R-HSA-9006925	Intracellular signaling by second messengers	Intracellular signaling by second messengers	28	1.967570e-15	4
REAC	REAC:R-HSA-1643685	Disease	Disease	64	5.135088e-15	4
REAC	REAC:R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	Diseases of signal transduction by growth factor receptors and second messengers	32	2.797323e-14	4
REAC	REAC:R-HSA-162582	Signal Transduction	Signal Transduction	71	5.442835e-12	4
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	44	1.386171e-11	4
REAC	REAC:R-HSA-1280215	Cytokine Signaling in Immune system	Cytokine Signaling in Immune system	37	4.794712e-11	4
REAC	REAC:R-HSA-1257604	PIP3 activates AKT signaling	PIP3 activates AKT signaling	22	7.444185e-11	4
REAC	REAC:R-HSA-4420097	VEGFA-VEGFR2 Pathway	VEGFA-VEGFR2 Pathway	15	1.007541e-10	4
REAC	REAC:R-HSA-194138	Signaling by VEGF	Signaling by VEGF	15	4.680293e-10	4
REAC	REAC:R-HSA-1280218	Adaptive Immune System	Adaptive Immune System	36	7.851634e-10	4
REAC	REAC:R-HSA-180024	DARPP-32 events	DARPP-32 events	9	1.025176e-09	4
REAC	REAC:R-HSA-168249	Innate Immune System	Innate Immune System	42	1.030408e-09	4
REAC	REAC:R-HSA-5610787	Hedgehog 'off' state	Hedgehog 'off' state	15	1.622949e-09	4
REAC	REAC:R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	Signaling by Receptor Tyrosine Kinases	28	3.654463e-09	4
REAC	REAC:R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	Formation of tubulin folding intermediates by CCT/TriC	9	3.803561e-09	4
REAC	REAC:R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	10	5.714708e-09	4
REAC	REAC:R-HSA-69275	G2/M Transition	G2/M Transition	18	6.025353e-09	4
REAC	REAC:R-HSA-453274	Mitotic G2-G2/M phases	Mitotic G2-G2/M phases	18	7.151487e-09	4
REAC	REAC:R-HSA-5358351	Signaling by Hedgehog	Signaling by Hedgehog	16	8.212497e-09	4
REAC	REAC:R-HSA-111885	Opioid Signalling	Opioid Signalling	13	1.178971e-08	4
REAC	REAC:R-HSA-390466	Chaperonin-mediated protein folding	Chaperonin-mediated protein folding	13	1.826812e-08	4
REAC	REAC:R-HSA-449147	Signaling by Interleukins	Signaling by Interleukins	26	1.978758e-08	4
REAC	REAC:R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	11	2.048053e-08	4
REAC	REAC:R-HSA-5621481	C-type lectin receptors (CLRs)	C-type lectin receptors (CLRs)	15	2.463228e-08	4
REAC	REAC:R-HSA-389357	CD28 dependent PI3K/Akt signaling	CD28 dependent PI3K/Akt signaling	8	3.588547e-08	4
REAC	REAC:R-HSA-8878166	Transcriptional regulation by RUNX2	Transcriptional regulation by RUNX2	14	4.122831e-08	4
REAC	REAC:R-HSA-391251	Protein folding	Protein folding	13	4.181326e-08	4
REAC	REAC:R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	9	4.376441e-08	4
REAC	REAC:R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	The role of GTSE1 in G2/M progression after G2 checkpoint	12	5.026211e-08	4
REAC	REAC:R-HSA-109582	Hemostasis	Hemostasis	30	8.384352e-08	4
REAC	REAC:R-HSA-6804757	Regulation of TP53 Degradation	Regulation of TP53 Degradation	9	1.036631e-07	4
REAC	REAC:R-HSA-6806003	Regulation of TP53 Expression and Degradation	Regulation of TP53 Expression and Degradation	9	1.356162e-07	4
REAC	REAC:R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	Regulation of mRNA stability by proteins that bind AU-rich elements	12	1.398700e-07	4
REAC	REAC:R-HSA-163685	Integration of energy metabolism	Integration of energy metabolism	13	1.469690e-07	4
REAC	REAC:R-HSA-8948751	Regulation of PTEN stability and activity	Regulation of PTEN stability and activity	11	1.794170e-07	4
REAC	REAC:R-HSA-390450	Folding of actin by CCT/TriC	Folding of actin by CCT/TriC	6	2.033727e-07	4
REAC	REAC:R-HSA-5218920	VEGFR2 mediated vascular permeability	VEGFR2 mediated vascular permeability	8	2.370093e-07	4
REAC	REAC:R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	AUF1 (hnRNP D0) binds and destabilizes mRNA	10	2.463012e-07	4
REAC	REAC:R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	Prefoldin mediated transfer of substrate to CCT/TriC	8	3.285167e-07	4
REAC	REAC:R-HSA-422475	Axon guidance	Axon guidance	26	3.485596e-07	4
REAC	REAC:R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	GLI3 is processed to GLI3R by the proteasome	10	7.305500e-07	4
REAC	REAC:R-HSA-5610783	Degradation of GLI2 by the proteasome	Degradation of GLI2 by the proteasome	10	7.305500e-07	4
REAC	REAC:R-HSA-5610780	Degradation of GLI1 by the proteasome	Degradation of GLI1 by the proteasome	10	7.305500e-07	4
REAC	REAC:R-HSA-389356	Co-stimulation by CD28	Co-stimulation by CD28	8	8.092113e-07	4
REAC	REAC:R-HSA-9675108	Nervous system development	Nervous system development	26	9.076122e-07	4
REAC	REAC:R-HSA-2262752	Cellular responses to stress	Cellular responses to stress	31	1.012594e-06	4
REAC	REAC:R-HSA-1227986	Signaling by ERBB2	Signaling by ERBB2	9	1.097354e-06	4
REAC	REAC:R-HSA-5357801	Programmed Cell Death	Programmed Cell Death	16	1.208988e-06	4
REAC	REAC:R-HSA-163359	Glucagon signaling in metabolic regulation	Glucagon signaling in metabolic regulation	8	1.396061e-06	4
REAC	REAC:R-HSA-8953897	Cellular responses to stimuli	Cellular responses to stimuli	31	1.539387e-06	4
REAC	REAC:R-HSA-5683057	MAPK family signaling cascades	MAPK family signaling cascades	19	1.636281e-06	4
REAC	REAC:R-HSA-388841	Regulation of T cell activation by CD28 family	Regulation of T cell activation by CD28 family	10	2.239715e-06	4
REAC	REAC:R-HSA-3371556	Cellular response to heat stress	Cellular response to heat stress	11	2.298570e-06	4
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	32	2.334572e-06	4
REAC	REAC:R-HSA-9013418	RHOBTB2 GTPase cycle	RHOBTB2 GTPase cycle	7	2.394747e-06	4
REAC	REAC:R-HSA-6807070	PTEN Regulation	PTEN Regulation	13	3.505890e-06	4
REAC	REAC:R-HSA-76002	Platelet activation, signaling and aggregation	Platelet activation, signaling and aggregation	17	4.173349e-06	4
REAC	REAC:R-HSA-392451	G beta:gamma signalling through PI3Kgamma	G beta:gamma signalling through PI3Kgamma	7	4.603503e-06	4
REAC	REAC:R-HSA-9009391	Extra-nuclear estrogen signaling	Extra-nuclear estrogen signaling	10	4.605297e-06	4
REAC	REAC:R-HSA-9010642	ROBO receptors bind AKAP5	ROBO receptors bind AKAP5	5	4.783572e-06	4
REAC	REAC:R-HSA-5607764	CLEC7A (Dectin-1) signaling	CLEC7A (Dectin-1) signaling	11	7.382396e-06	4
REAC	REAC:R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	Antiviral mechanism by IFN-stimulated genes	13	7.553723e-06	4
REAC	REAC:R-HSA-202424	Downstream TCR signaling	Downstream TCR signaling	11	8.232533e-06	4
REAC	REAC:R-HSA-8863795	Downregulation of ERBB2 signaling	Downregulation of ERBB2 signaling	7	8.337628e-06	4
REAC	REAC:R-HSA-9755511	KEAP1-NFE2L2 pathway	KEAP1-NFE2L2 pathway	12	9.938547e-06	4
REAC	REAC:R-HSA-69278	Cell Cycle, Mitotic	Cell Cycle, Mitotic	24	1.008589e-05	4
REAC	REAC:R-HSA-9660821	ADORA2B mediated anti-inflammatory cytokines production	ADORA2B mediated anti-inflammatory cytokines production	8	1.084860e-05	4
REAC	REAC:R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	8	1.084860e-05	4
REAC	REAC:R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	Fc epsilon receptor (FCERI) signaling	14	1.249320e-05	4
REAC	REAC:R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	Downstream signaling events of B Cell Receptor (BCR)	10	1.304838e-05	4
REAC	REAC:R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	Vasopressin regulates renal water homeostasis via Aquaporins	8	1.319597e-05	4
REAC	REAC:R-HSA-9634597	GPER1 signaling	GPER1 signaling	8	1.596832e-05	4
REAC	REAC:R-HSA-9646399	Aggrephagy	Aggrephagy	8	1.596832e-05	4
REAC	REAC:R-HSA-69202	Cyclin E associated events during G1/S transition	Cyclin E associated events during G1/S transition	10	1.661628e-05	4
REAC	REAC:R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	Cyclin A:Cdk2-associated events at S phase entry	10	2.101872e-05	4
REAC	REAC:R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	Neurotransmitter receptors and postsynaptic signal transmission	14	2.982930e-05	4
REAC	REAC:R-HSA-397795	G-protein beta:gamma signalling	G-protein beta:gamma signalling	7	3.007586e-05	4
REAC	REAC:R-HSA-1169091	Activation of NF-kappaB in B cells	Activation of NF-kappaB in B cells	9	3.450317e-05	4
REAC	REAC:R-HSA-5687128	MAPK6/MAPK4 signaling	MAPK6/MAPK4 signaling	10	3.681318e-05	4
REAC	REAC:R-HSA-442720	CREB1 phosphorylation through the activation of Adenylate Cyclase	CREB1 phosphorylation through the activation of Adenylate Cyclase	5	3.834589e-05	4
REAC	REAC:R-HSA-3858494	Beta-catenin independent WNT signaling	Beta-catenin independent WNT signaling	12	4.896014e-05	4
REAC	REAC:R-HSA-5684996	MAPK1/MAPK3 signaling	MAPK1/MAPK3 signaling	16	5.107184e-05	4
REAC	REAC:R-HSA-9706574	RHOBTB GTPase Cycle	RHOBTB GTPase Cycle	7	5.833012e-05	4
REAC	REAC:R-HSA-445717	Aquaporin-mediated transport	Aquaporin-mediated transport	8	6.260262e-05	4
REAC	REAC:R-HSA-109581	Apoptosis	Apoptosis	13	6.427868e-05	4
REAC	REAC:R-HSA-202403	TCR signaling	TCR signaling	11	6.834357e-05	4
REAC	REAC:R-HSA-9604323	Negative regulation of NOTCH4 signaling	Negative regulation of NOTCH4 signaling	8	7.300045e-05	4
REAC	REAC:R-HSA-446652	Interleukin-1 family signaling	Interleukin-1 family signaling	12	8.907648e-05	4
REAC	REAC:R-HSA-438064	Post NMDA receptor activation events	Post NMDA receptor activation events	9	9.354118e-05	4
REAC	REAC:R-HSA-9833482	PKR-mediated signaling	PKR-mediated signaling	9	9.354118e-05	4
REAC	REAC:R-HSA-376176	Signaling by ROBO receptors	Signaling by ROBO receptors	14	1.122144e-04	4
REAC	REAC:R-HSA-3371571	HSF1-dependent transactivation	HSF1-dependent transactivation	6	1.136744e-04	4
REAC	REAC:R-HSA-68886	M Phase	M Phase	19	1.262761e-04	4
REAC	REAC:R-HSA-422356	Regulation of insulin secretion	Regulation of insulin secretion	9	1.317999e-04	4
REAC	REAC:R-HSA-1640170	Cell Cycle	Cell Cycle	25	1.379610e-04	4
REAC	REAC:R-HSA-2467813	Separation of Sister Chromatids	Separation of Sister Chromatids	13	1.383194e-04	4
REAC	REAC:R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	Constitutive Signaling by AKT1 E17K in Cancer	6	1.481178e-04	4
REAC	REAC:R-HSA-112315	Transmission across Chemical Synapses	Transmission across Chemical Synapses	15	1.583107e-04	4
REAC	REAC:R-HSA-3371568	Attenuation phase	Attenuation phase	5	1.614585e-04	4
REAC	REAC:R-HSA-9663891	Selective autophagy	Selective autophagy	9	1.642759e-04	4
REAC	REAC:R-HSA-69206	G1/S Transition	G1/S Transition	11	1.672326e-04	4
REAC	REAC:R-HSA-9013694	Signaling by NOTCH4	Signaling by NOTCH4	9	1.829683e-04	4
REAC	REAC:R-HSA-5673001	RAF/MAP kinase cascade	RAF/MAP kinase cascade	15	2.339187e-04	4
REAC	REAC:R-HSA-5617833	Cilium Assembly	Cilium Assembly	13	2.812281e-04	4
REAC	REAC:R-HSA-9820965	Respiratory syncytial virus (RSV) genome replication, transcription and translation	Respiratory syncytial virus (RSV) genome replication, transcription and translation	5	3.455920e-04	4
REAC	REAC:R-HSA-9020702	Interleukin-1 signaling	Interleukin-1 signaling	10	3.531701e-04	4
REAC	REAC:R-HSA-442755	Activation of NMDA receptors and postsynaptic events	Activation of NMDA receptors and postsynaptic events	9	3.735715e-04	4
REAC	REAC:R-HSA-164378	PKA activation in glucagon signalling	PKA activation in glucagon signalling	5	4.849253e-04	4
REAC	REAC:R-HSA-2219528	PI3K/AKT Signaling in Cancer	PI3K/AKT Signaling in Cancer	9	4.972912e-04	4
REAC	REAC:R-HSA-4086400	PCP/CE pathway	PCP/CE pathway	9	5.457220e-04	4
REAC	REAC:R-HSA-453279	Mitotic G1 phase and G1/S transition	Mitotic G1 phase and G1/S transition	11	5.675147e-04	4
REAC	REAC:R-HSA-9612973	Autophagy	Autophagy	11	6.066160e-04	4
REAC	REAC:R-HSA-8939211	ESR-mediated signaling	ESR-mediated signaling	13	6.369285e-04	4
REAC	REAC:R-HSA-163615	PKA activation	PKA activation	5	6.650407e-04	4
REAC	REAC:R-HSA-9759194	Nuclear events mediated by NFE2L2	Nuclear events mediated by NFE2L2	9	7.162473e-04	4
REAC	REAC:R-HSA-8939902	Regulation of RUNX2 expression and activity	Regulation of RUNX2 expression and activity	8	7.323777e-04	4
REAC	REAC:R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	Regulation of activated PAK-2p34 by proteasome mediated degradation	7	7.470089e-04	4
REAC	REAC:R-HSA-111931	PKA-mediated phosphorylation of CREB	PKA-mediated phosphorylation of CREB	5	8.939618e-04	4
REAC	REAC:R-HSA-194315	Signaling by Rho GTPases	Signaling by Rho GTPases	24	8.975936e-04	4
REAC	REAC:R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	7	9.809652e-04	4
REAC	REAC:R-HSA-69610	p53-Independent DNA Damage Response	p53-Independent DNA Damage Response	7	9.809652e-04	4
REAC	REAC:R-HSA-180534	Vpu mediated degradation of CD4	Vpu mediated degradation of CD4	7	9.809652e-04	4
REAC	REAC:R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	p53-Independent G1/S DNA damage checkpoint	7	9.809652e-04	4
REAC	REAC:R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	Autodegradation of the E3 ubiquitin ligase COP1	7	9.809652e-04	4
REAC	REAC:R-HSA-9762114	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	7	9.809652e-04	4
REAC	REAC:R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	Ubiquitin-dependent degradation of Cyclin D	7	9.809652e-04	4
REAC	REAC:R-HSA-199418	Negative regulation of the PI3K/AKT network	Negative regulation of the PI3K/AKT network	9	1.013772e-03	4
REAC	REAC:R-HSA-111997	CaM pathway	CaM pathway	6	1.030222e-03	4
REAC	REAC:R-HSA-111933	Calmodulin induced events	Calmodulin induced events	6	1.030222e-03	4
REAC	REAC:R-HSA-180585	Vif-mediated degradation of APOBEC3G	Vif-mediated degradation of APOBEC3G	7	1.119134e-03	4
REAC	REAC:R-HSA-169911	Regulation of Apoptosis	Regulation of Apoptosis	7	1.119134e-03	4
REAC	REAC:R-HSA-913531	Interferon Signaling	Interferon Signaling	14	1.124917e-03	4
REAC	REAC:R-HSA-389513	Co-inhibition by CTLA4	Co-inhibition by CTLA4	5	1.180602e-03	4
REAC	REAC:R-HSA-68882	Mitotic Anaphase	Mitotic Anaphase	13	1.224676e-03	4
REAC	REAC:R-HSA-2555396	Mitotic Metaphase and Anaphase	Mitotic Metaphase and Anaphase	13	1.285371e-03	4
REAC	REAC:R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	24	1.297982e-03	4
REAC	REAC:R-HSA-8941858	Regulation of RUNX3 expression and activity	Regulation of RUNX3 expression and activity	7	1.444512e-03	4
REAC	REAC:R-HSA-4641257	Degradation of AXIN	Degradation of AXIN	7	1.444512e-03	4
REAC	REAC:R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	SCF-beta-TrCP mediated degradation of Emi1	7	1.444512e-03	4
REAC	REAC:R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	7	1.444512e-03	4
REAC	REAC:R-HSA-983705	Signaling by the B Cell Receptor (BCR)	Signaling by the B Cell Receptor (BCR)	11	1.462733e-03	4
REAC	REAC:R-HSA-111996	Ca-dependent events	Ca-dependent events	6	1.463224e-03	4
REAC	REAC:R-HSA-109704	PI3K Cascade	PI3K Cascade	6	1.463224e-03	4
REAC	REAC:R-HSA-9607240	FLT3 Signaling	FLT3 Signaling	6	1.463224e-03	4
REAC	REAC:R-HSA-5362768	Hh mutants are degraded by ERAD	Hh mutants are degraded by ERAD	7	1.634650e-03	4
REAC	REAC:R-HSA-1632852	Macroautophagy	Macroautophagy	10	1.679684e-03	4
REAC	REAC:R-HSA-4641258	Degradation of DVL	Degradation of DVL	7	1.845192e-03	4
REAC	REAC:R-HSA-69541	Stabilization of p53	Stabilization of p53	7	1.845192e-03	4
REAC	REAC:R-HSA-2871837	FCERI mediated NF-kB activation	FCERI mediated NF-kB activation	10	1.919096e-03	4
REAC	REAC:R-HSA-9613829	Chaperone Mediated Autophagy	Chaperone Mediated Autophagy	5	1.967303e-03	4
REAC	REAC:R-HSA-8853659	RET signaling	RET signaling	6	2.033834e-03	4
REAC	REAC:R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	Association of TriC/CCT with target proteins during biosynthesis	6	2.033834e-03	4
REAC	REAC:R-HSA-5676590	NIK-->noncanonical NF-kB signaling	NIK-->noncanonical NF-kB signaling	7	2.334389e-03	4
REAC	REAC:R-HSA-5387390	Hh mutants abrogate ligand secretion	Hh mutants abrogate ligand secretion	7	2.334389e-03	4
REAC	REAC:R-HSA-112399	IRS-mediated signalling	IRS-mediated signalling	6	2.380306e-03	4
REAC	REAC:R-HSA-195253	Degradation of beta-catenin by the destruction complex	Degradation of beta-catenin by the destruction complex	8	2.409417e-03	4
REAC	REAC:R-HSA-211163	AKT-mediated inactivation of FOXO1A	AKT-mediated inactivation of FOXO1A	3	2.594920e-03	4
REAC	REAC:R-HSA-165158	Activation of AKT2	Activation of AKT2	3	2.594920e-03	4
REAC	REAC:R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	Dectin-1 mediated noncanonical NF-kB signaling	7	2.616748e-03	4
REAC	REAC:R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	SCF(Skp2)-mediated degradation of p27/p21	7	2.616748e-03	4
REAC	REAC:R-HSA-1489509	DAG and IP3 signaling	DAG and IP3 signaling	6	2.773198e-03	4
REAC	REAC:R-HSA-5632684	Hedgehog 'on' state	Hedgehog 'on' state	8	2.881784e-03	4
REAC	REAC:R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	Regulation of PLK1 Activity at G2/M Transition	8	2.881784e-03	4
REAC	REAC:R-HSA-5678895	Defective CFTR causes cystic fibrosis	Defective CFTR causes cystic fibrosis	7	2.926925e-03	4
REAC	REAC:R-HSA-9711123	Cellular response to chemical stress	Cellular response to chemical stress	12	2.926927e-03	4
REAC	REAC:R-HSA-195721	Signaling by WNT	Signaling by WNT	15	3.025402e-03	4
REAC	REAC:R-HSA-163560	Triglyceride catabolism	Triglyceride catabolism	5	3.115174e-03	4
REAC	REAC:R-HSA-9006931	Signaling by Nuclear Receptors	Signaling by Nuclear Receptors	14	3.346523e-03	4
REAC	REAC:R-HSA-9634600	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	4	3.499852e-03	4
REAC	REAC:R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	Downregulation of ERBB2:ERBB3 signaling	4	3.499852e-03	4
REAC	REAC:R-HSA-9755779	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	4	3.499852e-03	4
REAC	REAC:R-HSA-1852241	Organelle biogenesis and maintenance	Organelle biogenesis and maintenance	14	3.620327e-03	4
REAC	REAC:R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	Autodegradation of Cdh1 by Cdh1:APC/C	7	4.046146e-03	4
REAC	REAC:R-HSA-4608870	Asymmetric localization of PCP proteins	Asymmetric localization of PCP proteins	7	4.046146e-03	4
REAC	REAC:R-HSA-2428924	IGF1R signaling cascade	IGF1R signaling cascade	6	4.277747e-03	4
REAC	REAC:R-HSA-2428928	IRS-related events triggered by IGF1R	IRS-related events triggered by IGF1R	6	4.277747e-03	4
REAC	REAC:R-HSA-1236974	ER-Phagosome pathway	ER-Phagosome pathway	8	4.416492e-03	4
REAC	REAC:R-HSA-5358346	Hedgehog ligand biogenesis	Hedgehog ligand biogenesis	7	4.489957e-03	4
REAC	REAC:R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	6	4.905165e-03	4
REAC	REAC:R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	7	4.973359e-03	4
REAC	REAC:R-HSA-69563	p53-Dependent G1 DNA Damage Response	p53-Dependent G1 DNA Damage Response	7	4.973359e-03	4
REAC	REAC:R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	p53-Dependent G1/S DNA damage checkpoint	7	4.973359e-03	4
REAC	REAC:R-HSA-388396	GPCR downstream signalling	GPCR downstream signalling	21	5.233369e-03	4
REAC	REAC:R-HSA-3371453	Regulation of HSF1-mediated heat shock response	Regulation of HSF1-mediated heat shock response	7	5.499073e-03	4
REAC	REAC:R-HSA-5658442	Regulation of RAS by GAPs	Regulation of RAS by GAPs	7	5.499073e-03	4
REAC	REAC:R-HSA-74751	Insulin receptor signalling cascade	Insulin receptor signalling cascade	6	5.604949e-03	4
REAC	REAC:R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	APC/C:Cdc20 mediated degradation of Securin	7	6.069949e-03	4
REAC	REAC:R-HSA-69615	G1/S DNA Damage Checkpoints	G1/S DNA Damage Checkpoints	7	6.069949e-03	4
REAC	REAC:R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	Recruitment of NuMA to mitotic centrosomes	8	6.094847e-03	4
REAC	REAC:R-HSA-163358	PKA-mediated phosphorylation of key metabolic factors	PKA-mediated phosphorylation of key metabolic factors	3	6.430718e-03	4
REAC	REAC:R-HSA-418555	G alpha (s) signalling events	G alpha (s) signalling events	10	6.471645e-03	4
REAC	REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	Transcriptional regulation by RUNX3	8	6.589431e-03	4
REAC	REAC:R-HSA-157118	Signaling by NOTCH	Signaling by NOTCH	12	7.658115e-03	4
REAC	REAC:R-HSA-418594	G alpha (i) signalling events	G alpha (i) signalling events	14	7.662956e-03	4
REAC	REAC:R-HSA-5633007	Regulation of TP53 Activity	Regulation of TP53 Activity	10	8.068555e-03	4
REAC	REAC:R-HSA-68949	Orc1 removal from chromatin	Orc1 removal from chromatin	7	8.084079e-03	4
REAC	REAC:R-HSA-112043	PLC beta mediated events	PLC beta mediated events	6	8.201427e-03	4
REAC	REAC:R-HSA-9705683	SARS-CoV-2-host interactions	SARS-CoV-2-host interactions	11	8.871490e-03	4
REAC	REAC:R-HSA-69242	S Phase	S Phase	10	8.986668e-03	4
REAC	REAC:R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	Cross-presentation of soluble exogenous antigens (endosomes)	6	9.255281e-03	4
REAC	REAC:R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	8	9.598776e-03	4
REAC	REAC:R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	CDK-mediated phosphorylation and removal of Cdc6	7	9.711036e-03	4
REAC	REAC:R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	7	9.711036e-03	4
REAC	REAC:R-HSA-195258	RHO GTPase Effectors	RHO GTPase Effectors	14	9.816992e-03	4
REAC	REAC:R-HSA-9664433	Leishmania parasite growth and survival	Leishmania parasite growth and survival	9	1.005210e-02	4
REAC	REAC:R-HSA-9662851	Anti-inflammatory response favouring Leishmania parasite infection	Anti-inflammatory response favouring Leishmania parasite infection	9	1.005210e-02	4
REAC	REAC:R-HSA-975155	MyD88 dependent cascade initiated on endosome	MyD88 dependent cascade initiated on endosome	8	1.032136e-02	4
REAC	REAC:R-HSA-168898	Toll-like Receptor Cascades	Toll-like Receptor Cascades	10	1.053162e-02	4
REAC	REAC:R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	7	1.062042e-02	4
REAC	REAC:R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	7	1.062042e-02	4
REAC	REAC:R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	Toll Like Receptor 7/8 (TLR7/8) Cascade	8	1.108899e-02	4
REAC	REAC:R-HSA-1234174	Cellular response to hypoxia	Cellular response to hypoxia	7	1.159881e-02	4
REAC	REAC:R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	Regulation of ornithine decarboxylase (ODC)	6	1.168992e-02	4
REAC	REAC:R-HSA-5218921	VEGFR2 mediated cell proliferation	VEGFR2 mediated cell proliferation	4	1.240066e-02	4
REAC	REAC:R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	APC/C:Cdc20 mediated degradation of mitotic proteins	7	1.265022e-02	4
REAC	REAC:R-HSA-983231	Factors involved in megakaryocyte development and platelet production	Factors involved in megakaryocyte development and platelet production	10	1.294211e-02	4
REAC	REAC:R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	Toll Like Receptor 9 (TLR9) Cascade	8	1.368470e-02	4
REAC	REAC:R-HSA-1236975	Antigen processing-Cross presentation	Antigen processing-Cross presentation	8	1.368470e-02	4
REAC	REAC:R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	7	1.377879e-02	4
REAC	REAC:R-HSA-112040	G-protein mediated events	G-protein mediated events	6	1.461452e-02	4
REAC	REAC:R-HSA-5619084	ABC transporter disorders	ABC transporter disorders	7	1.498885e-02	4
REAC	REAC:R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	4	1.606704e-02	4
REAC	REAC:R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	Signaling by Ligand-Responsive EGFR Variants in Cancer	4	1.606704e-02	4
REAC	REAC:R-HSA-9824272	Somitogenesis	Somitogenesis	6	1.809905e-02	4
REAC	REAC:R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	6	1.809905e-02	4
REAC	REAC:R-HSA-6798695	Neutrophil degranulation	Neutrophil degranulation	17	1.893546e-02	4
REAC	REAC:R-HSA-9658195	Leishmania infection	Leishmania infection	11	1.901661e-02	4
REAC	REAC:R-HSA-9824443	Parasitic Infection Pathways	Parasitic Infection Pathways	11	1.901661e-02	4
REAC	REAC:R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	Regulation of APC/C activators between G1/S and early anaphase	7	1.915352e-02	4
REAC	REAC:R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	Toll Like Receptor 4 (TLR4) Cascade	9	2.010016e-02	4
REAC	REAC:R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	Toll Like Receptor TLR6:TLR2 Cascade	8	2.041642e-02	4
REAC	REAC:R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	8	2.041642e-02	4
REAC	REAC:R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	DDX58/IFIH1-mediated induction of interferon-alpha/beta	7	2.073594e-02	4
REAC	REAC:R-HSA-8941332	RUNX2 regulates genes involved in cell migration	RUNX2 regulates genes involved in cell migration	3	2.211691e-02	4
REAC	REAC:R-HSA-8963896	HDL assembly	HDL assembly	3	2.211691e-02	4
REAC	REAC:R-HSA-163765	ChREBP activates metabolic gene expression	ChREBP activates metabolic gene expression	3	2.211691e-02	4
REAC	REAC:R-HSA-351202	Metabolism of polyamines	Metabolism of polyamines	6	2.454346e-02	4
REAC	REAC:R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	Toll Like Receptor 2 (TLR2) Cascade	8	2.470080e-02	4
REAC	REAC:R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	Toll Like Receptor TLR1:TLR2 Cascade	8	2.470080e-02	4
REAC	REAC:R-HSA-372790	Signaling by GPCR	Signaling by GPCR	21	2.692612e-02	4
REAC	REAC:R-HSA-112316	Neuronal System	Neuronal System	15	3.076814e-02	4
REAC	REAC:R-HSA-8979227	Triglyceride metabolism	Triglyceride metabolism	5	3.218783e-02	4
REAC	REAC:R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	APC/C-mediated degradation of cell cycle proteins	7	3.263960e-02	4
REAC	REAC:R-HSA-453276	Regulation of mitotic cell cycle	Regulation of mitotic cell cycle	7	3.263960e-02	4
REAC	REAC:R-HSA-9700206	Signaling by ALK in cancer	Signaling by ALK in cancer	7	3.507897e-02	4
REAC	REAC:R-HSA-9725370	Signaling by ALK fusions and activated point mutants	Signaling by ALK fusions and activated point mutants	7	3.507897e-02	4
REAC	REAC:R-HSA-69052	Switching of origins to a post-replicative state	Switching of origins to a post-replicative state	7	4.330345e-02	4
REAC	REAC:R-HSA-165159	MTOR signalling	MTOR signalling	5	4.670272e-02	4
REAC	REAC:R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	4	4.715421e-02	4

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04910	Insulin signaling pathway	Insulin signaling pathway	18	1.620627e-11	4
KEGG	KEGG:04010	MAPK signaling pathway	MAPK signaling pathway	24	7.843957e-11	4
KEGG	KEGG:04728	Dopaminergic synapse	Dopaminergic synapse	16	1.262496e-09	4
KEGG	KEGG:05417	Lipid and atherosclerosis	Lipid and atherosclerosis	19	3.953228e-09	4
KEGG	KEGG:05132	Salmonella infection	Salmonella infection	20	7.136078e-09	4
KEGG	KEGG:04931	Insulin resistance	Insulin resistance	14	1.171556e-08	4
KEGG	KEGG:05010	Alzheimer disease	Alzheimer disease	24	1.255748e-08	4
KEGG	KEGG:05012	Parkinson disease	Parkinson disease	20	2.192129e-08	4
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	Pathways of neurodegeneration - multiple diseases	26	3.698730e-08	4
KEGG	KEGG:04926	Relaxin signaling pathway	Relaxin signaling pathway	14	1.297202e-07	4
KEGG	KEGG:05163	Human cytomegalovirus infection	Human cytomegalovirus infection	17	4.902088e-07	4
KEGG	KEGG:04213	Longevity regulating pathway - multiple species	Longevity regulating pathway - multiple species	10	5.857194e-07	4
KEGG	KEGG:01521	EGFR tyrosine kinase inhibitor resistance	EGFR tyrosine kinase inhibitor resistance	11	5.909367e-07	4
KEGG	KEGG:04151	PI3K-Akt signaling pathway	PI3K-Akt signaling pathway	21	6.667224e-07	4
KEGG	KEGG:05205	Proteoglycans in cancer	Proteoglycans in cancer	16	1.033965e-06	4
KEGG	KEGG:05170	Human immunodeficiency virus 1 infection	Human immunodeficiency virus 1 infection	16	1.460411e-06	4
KEGG	KEGG:05020	Prion disease	Prion disease	18	1.470297e-06	4
KEGG	KEGG:04540	Gap junction	Gap junction	11	1.893634e-06	4
KEGG	KEGG:04725	Cholinergic synapse	Cholinergic synapse	12	2.701576e-06	4
KEGG	KEGG:05223	Non-small cell lung cancer	Non-small cell lung cancer	10	3.081899e-06	4
KEGG	KEGG:04140	Autophagy - animal	Autophagy - animal	14	3.221461e-06	4
KEGG	KEGG:05017	Spinocerebellar ataxia	Spinocerebellar ataxia	13	3.833966e-06	4
KEGG	KEGG:04722	Neurotrophin signaling pathway	Neurotrophin signaling pathway	12	4.412233e-06	4
KEGG	KEGG:04014	Ras signaling pathway	Ras signaling pathway	16	7.151361e-06	4
KEGG	KEGG:04062	Chemokine signaling pathway	Chemokine signaling pathway	14	1.900534e-05	4
KEGG	KEGG:04210	Apoptosis	Apoptosis	12	1.979830e-05	4
KEGG	KEGG:05221	Acute myeloid leukemia	Acute myeloid leukemia	9	2.095233e-05	4
KEGG	KEGG:04915	Estrogen signaling pathway	Estrogen signaling pathway	12	2.147425e-05	4
KEGG	KEGG:05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	PD-L1 expression and PD-1 checkpoint pathway in cancer	10	2.419304e-05	4
KEGG	KEGG:05032	Morphine addiction	Morphine addiction	10	2.419304e-05	4
KEGG	KEGG:04211	Longevity regulating pathway	Longevity regulating pathway	10	2.419304e-05	4
KEGG	KEGG:05165	Human papillomavirus infection	Human papillomavirus infection	18	2.971271e-05	4
KEGG	KEGG:04935	Growth hormone synthesis, secretion and action	Growth hormone synthesis, secretion and action	11	4.810858e-05	4
KEGG	KEGG:04919	Thyroid hormone signaling pathway	Thyroid hormone signaling pathway	11	5.233403e-05	4
KEGG	KEGG:05207	Chemical carcinogenesis - receptor activation	Chemical carcinogenesis - receptor activation	14	6.869256e-05	4
KEGG	KEGG:04150	mTOR signaling pathway	mTOR signaling pathway	12	8.891608e-05	4
KEGG	KEGG:05161	Hepatitis B	Hepatitis B	12	1.424851e-04	4
KEGG	KEGG:04012	ErbB signaling pathway	ErbB signaling pathway	9	1.493853e-04	4
KEGG	KEGG:05167	Kaposi sarcoma-associated herpesvirus infection	Kaposi sarcoma-associated herpesvirus infection	13	1.580902e-04	4
KEGG	KEGG:04371	Apelin signaling pathway	Apelin signaling pathway	11	1.951649e-04	4
KEGG	KEGG:05162	Measles	Measles	11	1.951649e-04	4
KEGG	KEGG:05169	Epstein-Barr virus infection	Epstein-Barr virus infection	13	1.988436e-04	4
KEGG	KEGG:04141	Protein processing in endoplasmic reticulum	Protein processing in endoplasmic reticulum	12	2.093846e-04	4
KEGG	KEGG:04612	Antigen processing and presentation	Antigen processing and presentation	8	3.207574e-04	4
KEGG	KEGG:04912	GnRH signaling pathway	GnRH signaling pathway	9	3.532189e-04	4
KEGG	KEGG:04660	T cell receptor signaling pathway	T cell receptor signaling pathway	10	3.626375e-04	4
KEGG	KEGG:04152	AMPK signaling pathway	AMPK signaling pathway	10	3.912311e-04	4
KEGG	KEGG:04071	Sphingolipid signaling pathway	Sphingolipid signaling pathway	10	3.912311e-04	4
KEGG	KEGG:01522	Endocrine resistance	Endocrine resistance	9	4.220315e-04	4
KEGG	KEGG:05200	Pathways in cancer	Pathways in cancer	21	4.829947e-04	4
KEGG	KEGG:05215	Prostate cancer	Prostate cancer	9	5.020573e-04	4
KEGG	KEGG:04611	Platelet activation	Platelet activation	10	5.261015e-04	4
KEGG	KEGG:05231	Choline metabolism in cancer	Choline metabolism in cancer	9	5.467304e-04	4
KEGG	KEGG:05214	Glioma	Glioma	8	6.057092e-04	4
KEGG	KEGG:05212	Pancreatic cancer	Pancreatic cancer	8	6.695365e-04	4
KEGG	KEGG:05220	Chronic myeloid leukemia	Chronic myeloid leukemia	8	6.695365e-04	4
KEGG	KEGG:04914	Progesterone-mediated oocyte maturation	Progesterone-mediated oocyte maturation	9	7.612235e-04	4
KEGG	KEGG:05213	Endometrial cancer	Endometrial cancer	7	1.034459e-03	4
KEGG	KEGG:04923	Regulation of lipolysis in adipocytes	Regulation of lipolysis in adipocytes	7	1.034459e-03	4
KEGG	KEGG:04662	B cell receptor signaling pathway	B cell receptor signaling pathway	8	1.080767e-03	4
KEGG	KEGG:04370	VEGF signaling pathway	VEGF signaling pathway	7	1.160924e-03	4
KEGG	KEGG:05145	Toxoplasmosis	Toxoplasmosis	9	1.216297e-03	4
KEGG	KEGG:04066	HIF-1 signaling pathway	HIF-1 signaling pathway	9	1.311147e-03	4
KEGG	KEGG:05418	Fluid shear stress and atherosclerosis	Fluid shear stress and atherosclerosis	10	1.364168e-03	4
KEGG	KEGG:05415	Diabetic cardiomyopathy	Diabetic cardiomyopathy	12	1.403165e-03	4
KEGG	KEGG:04510	Focal adhesion	Focal adhesion	12	1.403165e-03	4
KEGG	KEGG:04530	Tight junction	Tight junction	11	1.466160e-03	4
KEGG	KEGG:04726	Serotonergic synapse	Serotonergic synapse	9	1.634495e-03	4
KEGG	KEGG:04929	GnRH secretion	GnRH secretion	7	2.001331e-03	4
KEGG	KEGG:05131	Shigellosis	Shigellosis	13	2.122738e-03	4
KEGG	KEGG:04727	GABAergic synapse	GABAergic synapse	8	2.172616e-03	4
KEGG	KEGG:04664	Fc epsilon RI signaling pathway	Fc epsilon RI signaling pathway	7	2.711162e-03	4
KEGG	KEGG:04720	Long-term potentiation	Long-term potentiation	7	2.711162e-03	4
KEGG	KEGG:05222	Small cell lung cancer	Small cell lung cancer	8	2.770208e-03	4
KEGG	KEGG:03050	Proteasome	Proteasome	6	2.896395e-03	4
KEGG	KEGG:05166	Human T-cell leukemia virus 1 infection	Human T-cell leukemia virus 1 infection	12	3.004832e-03	4
KEGG	KEGG:05031	Amphetamine addiction	Amphetamine addiction	7	3.290672e-03	4
KEGG	KEGG:04261	Adrenergic signaling in cardiomyocytes	Adrenergic signaling in cardiomyocytes	10	3.350522e-03	4
KEGG	KEGG:05230	Central carbon metabolism in cancer	Central carbon metabolism in cancer	7	3.616506e-03	4
KEGG	KEGG:04218	Cellular senescence	Cellular senescence	10	3.746125e-03	4
KEGG	KEGG:04713	Circadian entrainment	Circadian entrainment	8	4.070376e-03	4
KEGG	KEGG:01524	Platinum drug resistance	Platinum drug resistance	7	4.347927e-03	4
KEGG	KEGG:04750	Inflammatory mediator regulation of TRP channels	Inflammatory mediator regulation of TRP channels	8	4.383589e-03	4
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	AGE-RAGE signaling pathway in diabetic complications	8	5.070609e-03	4
KEGG	KEGG:05142	Chagas disease	Chagas disease	8	5.446421e-03	4
KEGG	KEGG:05225	Hepatocellular carcinoma	Hepatocellular carcinoma	10	6.713752e-03	4
KEGG	KEGG:05203	Viral carcinogenesis	Viral carcinogenesis	11	6.903890e-03	4
KEGG	KEGG:04620	Toll-like receptor signaling pathway	Toll-like receptor signaling pathway	8	7.691740e-03	4
KEGG	KEGG:04922	Glucagon signaling pathway	Glucagon signaling pathway	8	8.222195e-03	4
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	Amyotrophic lateral sclerosis	15	8.493561e-03	4
KEGG	KEGG:04960	Aldosterone-regulated sodium reabsorption	Aldosterone-regulated sodium reabsorption	5	1.162045e-02	4
KEGG	KEGG:04724	Glutamatergic synapse	Glutamatergic synapse	8	1.366187e-02	4
KEGG	KEGG:05034	Alcoholism	Alcoholism	10	1.805977e-02	4
KEGG	KEGG:05016	Huntington disease	Huntington disease	13	1.917621e-02	4
KEGG	KEGG:04921	Oxytocin signaling pathway	Oxytocin signaling pathway	9	1.976511e-02	4
KEGG	KEGG:05160	Hepatitis C	Hepatitis C	9	2.396469e-02	4
KEGG	KEGG:05211	Renal cell carcinoma	Renal cell carcinoma	6	2.668755e-02	4
KEGG	KEGG:04962	Vasopressin-regulated water reabsorption	Vasopressin-regulated water reabsorption	5	2.688326e-02	4
KEGG	KEGG:04666	Fc gamma R-mediated phagocytosis	Fc gamma R-mediated phagocytosis	7	2.706420e-02	4
KEGG	KEGG:05130	Pathogenic Escherichia coli infection	Pathogenic Escherichia coli infection	10	2.755638e-02	4
KEGG	KEGG:04920	Adipocytokine signaling pathway	Adipocytokine signaling pathway	6	3.128764e-02	4
KEGG	KEGG:04380	Osteoclast differentiation	Osteoclast differentiation	8	3.527471e-02	4
KEGG	KEGG:05164	Influenza A	Influenza A	9	3.617393e-02	4
KEGG	KEGG:05218	Melanoma	Melanoma	6	3.648773e-02	4
KEGG	KEGG:04973	Carbohydrate digestion and absorption	Carbohydrate digestion and absorption	5	3.678557e-02	4
KEGG	KEGG:05146	Amoebiasis	Amoebiasis	7	3.698075e-02	4
KEGG	KEGG:04270	Vascular smooth muscle contraction	Vascular smooth muscle contraction	8	3.712177e-02	4
KEGG	KEGG:05135	Yersinia infection	Yersinia infection	8	4.314148e-02	4
KEGG	KEGG:04625	C-type lectin receptor signaling pathway	C-type lectin receptor signaling pathway	7	4.420503e-02	4
KEGG	KEGG:04918	Thyroid hormone synthesis	Thyroid hormone synthesis	6	4.552988e-02	4
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	Parathyroid hormone synthesis, secretion and action	7	4.684896e-02	4

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0340461	Ovary; ovarian stroma cells[≥Low]	Ovary; ovarian stroma cells[≥Low]	84	7.674290e-10	4
HPA	HPA:0340000	Ovary	Ovary	99	2.927008e-09	4
HPA	HPA:0291161	Liver; cholangiocytes[≥Low]	Liver; cholangiocytes[≥Low]	79	2.209099e-07	4
HPA	HPA:0050000	Breast	Breast	112	2.336380e-07	4
HPA	HPA:0100000	Cerebral cortex	Cerebral cortex	119	2.680157e-07	4
HPA	HPA:0050051	Breast; glandular cells[≥Low]	Breast; glandular cells[≥Low]	108	6.881888e-07	4
HPA	HPA:0160051	Endometrium 1; glandular cells[≥Low]	Endometrium 1; glandular cells[≥Low]	107	2.707371e-06	4
HPA	HPA:0130241	Colon; peripheral nerve/ganglion[≥Low]	Colon; peripheral nerve/ganglion[≥Low]	89	3.005769e-06	4
HPA	HPA:0530721	Spleen; cells in white pulp[≥Low]	Spleen; cells in white pulp[≥Low]	81	3.380035e-06	4
HPA	HPA:0130000	Colon	Colon	119	4.643420e-06	4
HPA	HPA:0180051	Epididymis; glandular cells[≥Low]	Epididymis; glandular cells[≥Low]	111	5.587939e-06	4
HPA	HPA:0180000	Epididymis	Epididymis	111	5.587939e-06	4
HPA	HPA:0170000	Endometrium 2	Endometrium 2	107	8.269126e-06	4
HPA	HPA:0180052	Epididymis; glandular cells[≥Medium]	Epididymis; glandular cells[≥Medium]	95	8.469094e-06	4
HPA	HPA:0170051	Endometrium 2; glandular cells[≥Low]	Endometrium 2; glandular cells[≥Low]	105	1.071884e-05	4
HPA	HPA:0570000	Testis	Testis	123	1.159756e-05	4
HPA	HPA:0460201	Skin 1; endothelial cells[≥Low]	Skin 1; endothelial cells[≥Low]	29	1.403504e-05	4
HPA	HPA:0060000	Bronchus	Bronchus	111	1.687945e-05	4
HPA	HPA:0471391	Skin 2; cells in basal layer[≥Low]	Skin 2; cells in basal layer[≥Low]	31	2.069418e-05	4
HPA	HPA:0600431	Tonsil; germinal center cells[≥Low]	Tonsil; germinal center cells[≥Low]	97	2.735018e-05	4
HPA	HPA:0630000	Cervix	Cervix	106	2.896932e-05	4
HPA	HPA:0400000	Rectum	Rectum	115	3.062983e-05	4
HPA	HPA:0160000	Endometrium 1	Endometrium 1	107	3.713504e-05	4
HPA	HPA:0461391	Skin 1; cells in basal layer[≥Low]	Skin 1; cells in basal layer[≥Low]	29	3.835001e-05	4
HPA	HPA:0310000	Lymph node	Lymph node	102	3.946780e-05	4
HPA	HPA:0350000	Pancreas	Pancreas	110	4.258102e-05	4
HPA	HPA:0470201	Skin 2; endothelial cells[≥Low]	Skin 2; endothelial cells[≥Low]	29	4.542314e-05	4
HPA	HPA:0610831	Urinary bladder; urothelial cells[≥Low]	Urinary bladder; urothelial cells[≥Low]	109	4.652186e-05	4
HPA	HPA:0610000	Urinary bladder	Urinary bladder	109	4.652186e-05	4
HPA	HPA:0050091	Breast; myoepithelial cells[≥Low]	Breast; myoepithelial cells[≥Low]	93	4.931888e-05	4
HPA	HPA:0150000	Duodenum	Duodenum	114	5.339016e-05	4
HPA	HPA:0310441	Lymph node; non-germinal center cells[≥Low]	Lymph node; non-germinal center cells[≥Low]	97	5.928152e-05	4
HPA	HPA:0471472	Skin 2; lymphocytes[≥Medium]	Skin 2; lymphocytes[≥Medium]	24	6.519591e-05	4
HPA	HPA:0060101	Bronchus; respiratory epithelial cells[≥Low]	Bronchus; respiratory epithelial cells[≥Low]	95	9.129941e-05	4
HPA	HPA:0030000	Appendix	Appendix	113	9.525939e-05	4
HPA	HPA:0630221	Cervix; squamous epithelial cells[≥Low]	Cervix; squamous epithelial cells[≥Low]	90	1.092118e-04	4
HPA	HPA:0600441	Tonsil; non-germinal center cells[≥Low]	Tonsil; non-germinal center cells[≥Low]	97	1.114164e-04	4
HPA	HPA:0610832	Urinary bladder; urothelial cells[≥Medium]	Urinary bladder; urothelial cells[≥Medium]	95	1.462224e-04	4
HPA	HPA:0020051	Adrenal gland; glandular cells[≥Low]	Adrenal gland; glandular cells[≥Low]	109	1.486191e-04	4
HPA	HPA:0210052	Fallopian tube; glandular cells[≥Medium]	Fallopian tube; glandular cells[≥Medium]	81	1.510626e-04	4
HPA	HPA:0350472	Pancreas; exocrine glandular cells[≥Medium]	Pancreas; exocrine glandular cells[≥Medium]	88	1.548686e-04	4
HPA	HPA:0090000	Cerebellum	Cerebellum	107	1.581930e-04	4
HPA	HPA:0020000	Adrenal gland	Adrenal gland	109	1.597010e-04	4
HPA	HPA:0220000	Gallbladder	Gallbladder	111	1.801186e-04	4
HPA	HPA:0220051	Gallbladder; glandular cells[≥Low]	Gallbladder; glandular cells[≥Low]	111	1.801186e-04	4
HPA	HPA:0470202	Skin 2; endothelial cells[≥Medium]	Skin 2; endothelial cells[≥Medium]	23	1.938275e-04	4
HPA	HPA:0600000	Tonsil	Tonsil	112	2.097701e-04	4
HPA	HPA:0460202	Skin 1; endothelial cells[≥Medium]	Skin 1; endothelial cells[≥Medium]	22	2.222150e-04	4
HPA	HPA:0351181	Pancreas; pancreatic endocrine cells[≥Low]	Pancreas; pancreatic endocrine cells[≥Low]	91	2.346272e-04	4
HPA	HPA:0100131	Cerebral cortex; neuronal cells[≥Low]	Cerebral cortex; neuronal cells[≥Low]	102	2.477005e-04	4
HPA	HPA:0270351	Kidney; cells in glomeruli[≥Low]	Kidney; cells in glomeruli[≥Low]	86	2.486177e-04	4
HPA	HPA:0471441	Skin 2; fibrohistiocytic cells[≥Low]	Skin 2; fibrohistiocytic cells[≥Low]	30	2.589836e-04	4
HPA	HPA:0471471	Skin 2; lymphocytes[≥Low]	Skin 2; lymphocytes[≥Low]	26	2.593473e-04	4
HPA	HPA:0210000	Fallopian tube	Fallopian tube	109	2.657099e-04	4
HPA	HPA:0100211	Cerebral cortex; neuropil[≥Low]	Cerebral cortex; neuropil[≥Low]	84	2.834346e-04	4
HPA	HPA:0250131	Hippocampus; neuronal cells[≥Low]	Hippocampus; neuronal cells[≥Low]	97	3.011786e-04	4
HPA	HPA:0210051	Fallopian tube; glandular cells[≥Low]	Fallopian tube; glandular cells[≥Low]	92	3.044419e-04	4
HPA	HPA:0350471	Pancreas; exocrine glandular cells[≥Low]	Pancreas; exocrine glandular cells[≥Low]	104	3.138413e-04	4
HPA	HPA:0550051	Stomach 2; glandular cells[≥Low]	Stomach 2; glandular cells[≥Low]	110	3.433833e-04	4
HPA	HPA:0550000	Stomach 2	Stomach 2	110	3.433833e-04	4
HPA	HPA:0461471	Skin 1; lymphocytes[≥Low]	Skin 1; lymphocytes[≥Low]	24	3.773680e-04	4
HPA	HPA:0461461	Skin 1; langerhans cells[≥Low]	Skin 1; langerhans cells[≥Low]	24	4.064977e-04	4
HPA	HPA:0380000	Placenta	Placenta	109	4.214333e-04	4
HPA	HPA:0320000	Nasopharynx	Nasopharynx	106	4.907193e-04	4
HPA	HPA:0190000	Esophagus	Esophagus	101	4.995341e-04	4
HPA	HPA:0190221	Esophagus; squamous epithelial cells[≥Low]	Esophagus; squamous epithelial cells[≥Low]	101	4.995341e-04	4
HPA	HPA:0471461	Skin 2; langerhans cells[≥Low]	Skin 2; langerhans cells[≥Low]	25	6.601282e-04	4
HPA	HPA:0590000	Thyroid gland	Thyroid gland	105	6.620274e-04	4
HPA	HPA:0590051	Thyroid gland; glandular cells[≥Low]	Thyroid gland; glandular cells[≥Low]	105	6.620274e-04	4
HPA	HPA:0250132	Hippocampus; neuronal cells[≥Medium]	Hippocampus; neuronal cells[≥Medium]	74	6.940016e-04	4
HPA	HPA:0500000	Soft tissue 1	Soft tissue 1	87	7.070349e-04	4
HPA	HPA:0250121	Hippocampus; glial cells[≥Low]	Hippocampus; glial cells[≥Low]	73	7.102126e-04	4
HPA	HPA:0050052	Breast; glandular cells[≥Medium]	Breast; glandular cells[≥Medium]	84	7.892597e-04	4
HPA	HPA:0250000	Hippocampus	Hippocampus	102	7.894297e-04	4
HPA	HPA:0130242	Colon; peripheral nerve/ganglion[≥Medium]	Colon; peripheral nerve/ganglion[≥Medium]	64	7.989892e-04	4
HPA	HPA:0600432	Tonsil; germinal center cells[≥Medium]	Tonsil; germinal center cells[≥Medium]	72	1.067230e-03	4
HPA	HPA:0461411	Skin 1; cells in spinous layer[≥Low]	Skin 1; cells in spinous layer[≥Low]	24	1.151990e-03	4
HPA	HPA:0310431	Lymph node; germinal center cells[≥Low]	Lymph node; germinal center cells[≥Low]	83	1.160688e-03	4
HPA	HPA:0471411	Skin 2; cells in spinous layer[≥Low]	Skin 2; cells in spinous layer[≥Low]	26	1.204875e-03	4
HPA	HPA:0550052	Stomach 2; glandular cells[≥Medium]	Stomach 2; glandular cells[≥Medium]	96	1.327004e-03	4
HPA	HPA:0530000	Spleen	Spleen	92	1.375330e-03	4
HPA	HPA:0100132	Cerebral cortex; neuronal cells[≥Medium]	Cerebral cortex; neuronal cells[≥Medium]	82	1.425179e-03	4
HPA	HPA:0130051	Colon; glandular cells[≥Low]	Colon; glandular cells[≥Low]	103	1.439833e-03	4
HPA	HPA:0420000	Salivary gland	Salivary gland	102	1.554221e-03	4
HPA	HPA:0420051	Salivary gland; glandular cells[≥Low]	Salivary gland; glandular cells[≥Low]	102	1.554221e-03	4
HPA	HPA:0060102	Bronchus; respiratory epithelial cells[≥Medium]	Bronchus; respiratory epithelial cells[≥Medium]	81	1.582263e-03	4
HPA	HPA:0461441	Skin 1; fibrohistiocytic cells[≥Low]	Skin 1; fibrohistiocytic cells[≥Low]	26	1.609899e-03	4
HPA	HPA:0270000	Kidney	Kidney	114	1.656463e-03	4
HPA	HPA:0471442	Skin 2; fibrohistiocytic cells[≥Medium]	Skin 2; fibrohistiocytic cells[≥Medium]	25	1.733141e-03	4
HPA	HPA:0461472	Skin 1; lymphocytes[≥Medium]	Skin 1; lymphocytes[≥Medium]	20	1.973632e-03	4
HPA	HPA:0320101	Nasopharynx; respiratory epithelial cells[≥Low]	Nasopharynx; respiratory epithelial cells[≥Low]	90	2.255511e-03	4
HPA	HPA:0010000	Adipose tissue	Adipose tissue	69	2.515635e-03	4
HPA	HPA:0010011	Adipose tissue; adipocytes[≥Low]	Adipose tissue; adipocytes[≥Low]	69	2.515635e-03	4
HPA	HPA:0600221	Tonsil; squamous epithelial cells[≥Low]	Tonsil; squamous epithelial cells[≥Low]	99	2.521152e-03	4
HPA	HPA:0030051	Appendix; glandular cells[≥Low]	Appendix; glandular cells[≥Low]	100	2.536952e-03	4
HPA	HPA:0430052	Seminal vesicle; glandular cells[≥Medium]	Seminal vesicle; glandular cells[≥Medium]	84	2.666531e-03	4
HPA	HPA:0190222	Esophagus; squamous epithelial cells[≥Medium]	Esophagus; squamous epithelial cells[≥Medium]	82	2.669375e-03	4
HPA	HPA:0630051	Cervix; glandular cells[≥Low]	Cervix; glandular cells[≥Low]	89	2.678689e-03	4
HPA	HPA:0360051	Parathyroid gland; glandular cells[≥Low]	Parathyroid gland; glandular cells[≥Low]	91	3.051266e-03	4
HPA	HPA:0360000	Parathyroid gland	Parathyroid gland	91	3.051266e-03	4
HPA	HPA:0530722	Spleen; cells in white pulp[≥Medium]	Spleen; cells in white pulp[≥Medium]	53	3.428168e-03	4
HPA	HPA:0030071	Appendix; lymphoid tissue[≥Low]	Appendix; lymphoid tissue[≥Low]	78	3.483786e-03	4
HPA	HPA:0290000	Liver	Liver	95	3.608852e-03	4
HPA	HPA:0400052	Rectum; glandular cells[≥Medium]	Rectum; glandular cells[≥Medium]	93	3.705867e-03	4
HPA	HPA:0150051	Duodenum; glandular cells[≥Low]	Duodenum; glandular cells[≥Low]	103	3.936926e-03	4
HPA	HPA:0310442	Lymph node; non-germinal center cells[≥Medium]	Lymph node; non-germinal center cells[≥Medium]	69	4.015354e-03	4
HPA	HPA:0460181	Skin 1; cells in granular layer[≥Low]	Skin 1; cells in granular layer[≥Low]	22	4.226677e-03	4
HPA	HPA:0170251	Endometrium 2; cells in endometrial stroma[≥Low]	Endometrium 2; cells in endometrial stroma[≥Low]	63	4.562352e-03	4
HPA	HPA:0540051	Stomach 1; glandular cells[≥Low]	Stomach 1; glandular cells[≥Low]	108	4.870348e-03	4
HPA	HPA:0540000	Stomach 1	Stomach 1	108	4.870348e-03	4
HPA	HPA:0430051	Seminal vesicle; glandular cells[≥Low]	Seminal vesicle; glandular cells[≥Low]	100	5.001147e-03	4
HPA	HPA:0430000	Seminal vesicle	Seminal vesicle	100	5.001147e-03	4
HPA	HPA:0470181	Skin 2; cells in granular layer[≥Low]	Skin 2; cells in granular layer[≥Low]	22	5.139736e-03	4
HPA	HPA:0050092	Breast; myoepithelial cells[≥Medium]	Breast; myoepithelial cells[≥Medium]	66	5.377338e-03	4
HPA	HPA:0090191	Cerebellum; cells in molecular layer[≥Low]	Cerebellum; cells in molecular layer[≥Low]	74	6.341610e-03	4
HPA	HPA:0170052	Endometrium 2; glandular cells[≥Medium]	Endometrium 2; glandular cells[≥Medium]	79	6.400530e-03	4
HPA	HPA:0100201	Cerebral cortex; endothelial cells[≥Low]	Cerebral cortex; endothelial cells[≥Low]	76	6.663444e-03	4
HPA	HPA:0080000	Caudate	Caudate	101	6.910654e-03	4
HPA	HPA:0270362	Kidney; cells in tubules[≥Medium]	Kidney; cells in tubules[≥Medium]	89	8.479299e-03	4
HPA	HPA:0380511	Placenta; decidual cells[≥Low]	Placenta; decidual cells[≥Low]	78	9.033818e-03	4
HPA	HPA:0040081	Bone marrow; hematopoietic cells[≥Low]	Bone marrow; hematopoietic cells[≥Low]	96	9.064147e-03	4
HPA	HPA:0040000	Bone marrow	Bone marrow	96	9.064147e-03	4
HPA	HPA:0160251	Endometrium 1; cells in endometrial stroma[≥Low]	Endometrium 1; cells in endometrial stroma[≥Low]	69	9.416987e-03	4
HPA	HPA:0510000	Soft tissue 2	Soft tissue 2	82	9.964041e-03	4
HPA	HPA:0461442	Skin 1; fibrohistiocytic cells[≥Medium]	Skin 1; fibrohistiocytic cells[≥Medium]	21	1.045207e-02	4
HPA	HPA:0291162	Liver; cholangiocytes[≥Medium]	Liver; cholangiocytes[≥Medium]	41	1.146528e-02	4
HPA	HPA:0420052	Salivary gland; glandular cells[≥Medium]	Salivary gland; glandular cells[≥Medium]	78	1.192514e-02	4
HPA	HPA:0480000	Small intestine	Small intestine	109	1.250166e-02	4
HPA	HPA:0460000	Skin 1	Skin 1	103	1.278367e-02	4
HPA	HPA:0351182	Pancreas; pancreatic endocrine cells[≥Medium]	Pancreas; pancreatic endocrine cells[≥Medium]	63	1.291515e-02	4
HPA	HPA:0510651	Soft tissue 2; fibroblasts[≥Low]	Soft tissue 2; fibroblasts[≥Low]	69	1.425042e-02	4
HPA	HPA:0471473	Skin 2; lymphocytes[High]	Skin 2; lymphocytes[High]	16	1.576631e-02	4
HPA	HPA:0400051	Rectum; glandular cells[≥Low]	Rectum; glandular cells[≥Low]	101	1.592139e-02	4
HPA	HPA:0460203	Skin 1; endothelial cells[High]	Skin 1; endothelial cells[High]	13	1.696862e-02	4
HPA	HPA:0390000	Prostate	Prostate	97	1.730836e-02	4
HPA	HPA:0390051	Prostate; glandular cells[≥Low]	Prostate; glandular cells[≥Low]	97	1.730836e-02	4
HPA	HPA:0360052	Parathyroid gland; glandular cells[≥Medium]	Parathyroid gland; glandular cells[≥Medium]	72	1.851798e-02	4
HPA	HPA:0080121	Caudate; glial cells[≥Low]	Caudate; glial cells[≥Low]	74	1.855492e-02	4
HPA	HPA:0301371	Lung; alveolar cells type II[≥Low]	Lung; alveolar cells type II[≥Low]	34	2.080071e-02	4
HPA	HPA:0220052	Gallbladder; glandular cells[≥Medium]	Gallbladder; glandular cells[≥Medium]	96	2.333770e-02	4
HPA	HPA:0470000	Skin 2	Skin 2	100	2.842802e-02	4
HPA	HPA:0461392	Skin 1; cells in basal layer[≥Medium]	Skin 1; cells in basal layer[≥Medium]	19	2.851137e-02	4
HPA	HPA:0160052	Endometrium 1; glandular cells[≥Medium]	Endometrium 1; glandular cells[≥Medium]	80	2.879623e-02	4
HPA	HPA:0540052	Stomach 1; glandular cells[≥Medium]	Stomach 1; glandular cells[≥Medium]	93	2.892047e-02	4
HPA	HPA:0500111	Soft tissue 1; chondrocytes[≥Low]	Soft tissue 1; chondrocytes[≥Low]	43	2.993229e-02	4
HPA	HPA:0471392	Skin 2; cells in basal layer[≥Medium]	Skin 2; cells in basal layer[≥Medium]	21	3.162427e-02	4
HPA	HPA:0570731	Testis; Leydig cells[≥Low]	Testis; Leydig cells[≥Low]	101	3.170336e-02	4
HPA	HPA:0130052	Colon; glandular cells[≥Medium]	Colon; glandular cells[≥Medium]	89	3.189696e-02	4
HPA	HPA:0461412	Skin 1; cells in spinous layer[≥Medium]	Skin 1; cells in spinous layer[≥Medium]	18	3.390512e-02	4
HPA	HPA:0320102	Nasopharynx; respiratory epithelial cells[≥Medium]	Nasopharynx; respiratory epithelial cells[≥Medium]	75	3.643876e-02	4
HPA	HPA:0100121	Cerebral cortex; glial cells[≥Low]	Cerebral cortex; glial cells[≥Low]	77	3.818784e-02	4
HPA	HPA:0480051	Small intestine; glandular cells[≥Low]	Small intestine; glandular cells[≥Low]	100	4.073876e-02	4
HPA	HPA:0510701	Soft tissue 2; peripheral nerve[≥Low]	Soft tissue 2; peripheral nerve[≥Low]	56	4.105637e-02	4

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:126	CCT complex (chaperonin containing TCP1 complex)	CCT complex (chaperonin containing TCP1 complex)	6	4.331627e-07	4
CORUM	CORUM:2112	CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex	CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex	4	3.391606e-05	4
CORUM	CORUM:5269	TNF-alpha/NF-kappa B signaling complex 8	TNF-alpha/NF-kappa B signaling complex 8	4	4.910752e-04	4
CORUM	CORUM:6512	ILK-HSP90-CDC37 complex	ILK-HSP90-CDC37 complex	3	1.528484e-03	4
CORUM	CORUM:5268	TNF-alpha/NF-kappa B signaling complex 7	TNF-alpha/NF-kappa B signaling complex 7	4	2.212186e-03	4
CORUM	CORUM:5199	Kinase maturation complex 1	Kinase maturation complex 1	5	2.657283e-03	4
CORUM	CORUM:5286	TNF-alpha/NF-kappa B signaling complex 10	TNF-alpha/NF-kappa B signaling complex 10	4	6.406568e-03	4
CORUM	CORUM:6247	BBS-chaperonin complex	BBS-chaperonin complex	4	6.406568e-03	4
CORUM	CORUM:32	PA700 complex	PA700 complex	5	8.772901e-03	4
CORUM	CORUM:5285	TNF-alpha/NF-kappa B signaling complex 9	TNF-alpha/NF-kappa B signaling complex 9	3	1.478055e-02	4
CORUM	CORUM:5234	IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex	IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex	3	1.478055e-02	4
CORUM	CORUM:5266	TNF-alpha/NF-kappa B signaling complex 6	TNF-alpha/NF-kappa B signaling complex 6	4	2.069027e-02	4

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-16-5p	hsa-mir-16-5p	hsa-mir-16-5p	37	0.000003	4
MIRNA	MIRNA:hsa-mir-615-3p	hsa-mir-615-3p	hsa-mir-615-3p	28	0.000009	4
MIRNA	MIRNA:hsa-mir-92a-3p	hsa-mir-92a-3p	hsa-mir-92a-3p	32	0.000070	4
MIRNA	MIRNA:hsa-mir-324-3p	hsa-mir-324-3p	hsa-mir-324-3p	35	0.000139	4
MIRNA	MIRNA:hsa-mir-331-3p	hsa-mir-331-3p	hsa-mir-331-3p	29	0.000890	4
MIRNA	MIRNA:hsa-mir-744-5p	hsa-mir-744-5p	hsa-mir-744-5p	15	0.001700	4
MIRNA	MIRNA:hsa-mir-495	hsa-mir-495	hsa-mir-495	35	0.002242	4
MIRNA	MIRNA:hsa-mir-320a	hsa-mir-320a	hsa-mir-320a	34	0.003268	4
MIRNA	MIRNA:hsa-mir-23b-3p	hsa-mir-23b-3p	hsa-mir-23b-3p	13	0.003390	4
MIRNA	MIRNA:hsa-mir-193b-3p	hsa-mir-193b-3p	hsa-mir-193b-3p	21	0.006966	4
MIRNA	MIRNA:hsa-mir-944	hsa-mir-944	hsa-mir-944	29	0.008953	4
MIRNA	MIRNA:hsa-mir-218-5p	hsa-mir-218-5p	hsa-mir-218-5p	20	0.020088	4
MIRNA	MIRNA:hsa-mir-149-5p	hsa-mir-149-5p	hsa-mir-149-5p	13	0.024676	4
MIRNA	MIRNA:hsa-mir-484	hsa-mir-484	hsa-mir-484	35	0.035337	4
MIRNA	MIRNA:hsa-mir-455-3p	hsa-mir-455-3p	hsa-mir-455-3p	27	0.037434	4

HP

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0100315	Lewy bodies	Lewy bodies	8	0.000004	4
HP	HP:0100314	Cerebral inclusion bodies	Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain.	9	0.000024	4
HP	HP:0011960	Substantia nigra gliosis	Focal proliferation of glial cells in the substantia nigra.	5	0.000762	4
HP	HP:0002171	Gliosis	Gliosis is the focal proliferation of glial cells in the central nervous system.	10	0.001057	4
HP	HP:0002362	Shuffling gait	A type of gait (walking) characterized by by dragging one's feet along or without lifting the feet fully from the ground.	7	0.001573	4
HP	HP:0002322	Resting tremor	A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse.	8	0.001579	4
HP	HP:0002548	Parkinsonism with favorable response to dopaminergic medication	Parkinsonism is a clinical syndrome that is a feature of a number of different diseases, including Parkinson disease itself, other neurodegenerative diseases such as progressive supranuclear palsy, and as a side-effect of some neuroleptic medications. Some but not all individuals with Parkinsonism show responsiveness to dopaminergic medication defined as a substantial reduction of amelioration of the component signs of Parkinsonism (including mainly tremor, bradykinesia, rigidity, and postural instability) upon administration of dopaminergic medication.	6	0.001921	4
HP	HP:0001300	Parkinsonism	Characteristic neurologic anomaly resulting from degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait.	11	0.003051	4
HP	HP:0002172	Postural instability	A tendency to fall or the inability to keep oneself from falling; imbalance. The retropulsion test is widely regarded as the gold standard to evaluate postural instability, Use of the retropulsion test includes a rapid balance perturbation in the backward direction, and the number of balance correcting steps (or total absence thereof) is used to rate the degree of postural instability. Healthy subjects correct such perturbations with either one or two large steps, or without taking any steps, hinging rapidly at the hips while swinging the arms forward as a counterweight. In patients with balance impairment, balance correcting steps are often too small, forcing patients to take more than two steps. Taking three or more steps is generally considered to be abnormal, and taking more than five steps is regarded as being clearly abnormal. Markedly affected patients continue to step backward without ever regaining their balance and must be caught by the examiner (this would be called true retropulsion). Even more severely affected patients fail to correct entirely, and fall backward like a pushed toy soldier, without taking any corrective steps.	9	0.005788	4
HP	HP:0031435	Monotonic speech	A speech pattern characterized by a persistently abnormal lack of tone in the voice. Monotonic speech is typically ongoing, lasting throughout the day, but may have a diurnal variation in the pattern, i.e. slower at specific times of the day.	4	0.006021	4
HP	HP:0003587	Insidious onset	Gradual, very slow onset of disease manifestations.	5	0.006462	4
HP	HP:0008364	Abnormality of the calcaneus	An abnormality of the calcaneus, also known as the heel bone, one of the or heel bone, one of the components of the tarsus of the foot which make up the heel.	6	0.011482	4
HP	HP:0045007	Abnormal substantia nigra morphology	A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry.	5	0.014179	4
HP	HP:0011008	Temporal pattern	The speed at which disease manifestations appear and develop.	5	0.017927	4
HP	HP:0002538	Abnormal cerebral cortex morphology	Any structural abnormality of the cerebral cortex.	23	0.045583	4
HP	HP:0011877	Increased mean platelet volume	Average platelet volume above the upper limit of the normal reference interval.	5	0.049675	4

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M08309	Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN	Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN	126	0.000446	4
TF	TF:M07206	Factor: E2F-1; motif: NGGGCGGGARV	Factor: E2F-1; motif: NGGGCGGGARV	137	0.000479	4
TF	TF:M12666	Factor: SP1; motif: GGCCCCGCCCCCN	Factor: SP1; motif: GGCCCCGCCCCCN	98	0.000636	4
TF	TF:M00196	Factor: Sp1; motif: NGGGGGCGGGGYN	Factor: Sp1; motif: NGGGGGCGGGGYN	109	0.001149	4
TF	TF:M12151	Factor: Sp1; motif: NWRGCCMCGCCCMCN	Factor: Sp1; motif: NWRGCCMCGCCCMCN	82	0.001975	4
TF	TF:M11601_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	114	0.002083	4
TF	TF:M02036_1	Factor: WT1; motif: CGCCCCCNCN; match class: 1	Factor: WT1; motif: CGCCCCCNCN; match class: 1	69	0.002209	4
TF	TF:M01660	Factor: GABP-alpha; motif: CTTCCK	Factor: GABP-alpha; motif: CTTCCK	113	0.003841	4
TF	TF:M00716	Factor: ZF5; motif: GSGCGCGR	Factor: ZF5; motif: GSGCGCGR	143	0.004122	4
TF	TF:M11435	Factor: Elk-1; motif: NNCCGGAAGTN	Factor: Elk-1; motif: NNCCGGAAGTN	117	0.004683	4
TF	TF:M02070	Factor: TEL1; motif: CNCGGAANNN	Factor: TEL1; motif: CNCGGAANNN	111	0.004888	4
TF	TF:M07395	Factor: Sp1; motif: NGGGGCGGGGN	Factor: Sp1; motif: NGGGGCGGGGN	110	0.005594	4
TF	TF:M09950_1	Factor: HSF1; motif: NRGAANNTTCYRGAA; match class: 1	Factor: HSF1; motif: NRGAANNTTCYRGAA; match class: 1	11	0.008827	4
TF	TF:M09765	Factor: SP1; motif: NRGKGGGCGGGGCN	Factor: SP1; motif: NRGKGGGCGGGGCN	85	0.012031	4
TF	TF:M08226_1	Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1	Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1	69	0.014513	4
TF	TF:M11656_1	Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1	Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1	10	0.017571	4
TF	TF:M00932	Factor: Sp1; motif: NNGGGGCGGGGNN	Factor: Sp1; motif: NNGGGGCGGGGNN	107	0.018018	4
TF	TF:M00931	Factor: Sp1; motif: GGGGCGGGGC	Factor: Sp1; motif: GGGGCGGGGC	106	0.018021	4
TF	TF:M02053	Factor: ELF1; motif: NCCGGAARTN	Factor: ELF1; motif: NCCGGAARTN	72	0.019483	4
TF	TF:M02059	Factor: ELK-1; motif: ACCGGAAGTN	Factor: ELK-1; motif: ACCGGAAGTN	99	0.019613	4
TF	TF:M00716_1	Factor: ZF5; motif: GSGCGCGR; match class: 1	Factor: ZF5; motif: GSGCGCGR; match class: 1	131	0.022317	4
TF	TF:M00736	Factor: E2F-1:DP-1; motif: TTTCSCGC	Factor: E2F-1:DP-1; motif: TTTCSCGC	106	0.022951	4
TF	TF:M02089_1	Factor: E2F-3; motif: GGCGGGN; match class: 1	Factor: E2F-3; motif: GGCGGGN; match class: 1	99	0.023419	4
TF	TF:M07395_1	Factor: Sp1; motif: NGGGGCGGGGN; match class: 1	Factor: Sp1; motif: NGGGGCGGGGN; match class: 1	75	0.026453	4
TF	TF:M13135	Factor: SP4; motif: GGCCCCGCCCCCN	Factor: SP4; motif: GGCCCCGCCCCCN	68	0.029266	4
TF	TF:M02052	Factor: EHF; motif: CSCGGAARTN	Factor: EHF; motif: CSCGGAARTN	103	0.035173	4
TF	TF:M03807	Factor: SP2; motif: GNNGGGGGCGGGGSN	Factor: SP2; motif: GNNGGGGGCGGGGSN	91	0.039027	4
TF	TF:M08911	Factor: CTCF; motif: NCCRSTAGGGGGCGC	Factor: CTCF; motif: NCCRSTAGGGGGCGC	96	0.041809	4
TF	TF:M12173_1	Factor: GKLF; motif: NNCCMCRCCCN; match class: 1	Factor: GKLF; motif: NNCCMCRCCCN; match class: 1	62	0.048775	4
TF	TF:M09723_1	Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1	Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1	71	0.049361	4

WashU (Leiden)

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WashU (Louvain)

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Community 0

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:177	OGT-TRAK1-TRAK2 complex	OGT-TRAK1-TRAK2 complex	2	0.002292	0

REAC

source	term_id	annotation	description	intersection_size	p_value
REAC	REAC:R-HSA-9013425	RHOT1 GTPase cycle	RHOT1 GTPase cycle	2	0.005511
REAC	REAC:R-HSA-9013419	RHOT2 GTPase cycle	RHOT2 GTPase cycle	2	0.011554
REAC	REAC:R-HSA-9715370	Miro GTPase Cycle	Miro GTPase Cycle	2	0.015393

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0051018	protein kinase A binding	"Binding to a protein kinase A." [GOC:ai]	3	0.012932	0

MIRNA

source	term_id	annotation	description	intersection_size	p_value
MIRNA	MIRNA:hsa-mir-512-3p	hsa-mir-512-3p	hsa-mir-512-3p	10	0.025402
MIRNA	MIRNA:hsa-mir-4473	hsa-mir-4473	hsa-mir-4473	6	0.032516
MIRNA	MIRNA:hsa-mir-633	hsa-mir-633	hsa-mir-633	7	0.046259

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0098957	anterograde axonal transport of mitochondrion	"The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [GOC:dos]	2	0.034999	0

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04660	T cell receptor signaling pathway	T cell receptor signaling pathway	3	0.037786	0

Community 1

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	13	1.030146e-12	1
GO:CC	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	8	1.074415e-08	1

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	8	0.000210	1
GO:MF	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	8	0.000259	1
GO:MF	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	8	0.000404	1
GO:MF	GO:0035639	purine ribonucleoside triphosphate binding	"Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732]	8	0.002383	1
GO:MF	GO:0032555	purine ribonucleotide binding	"Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	8	0.002948	1
GO:MF	GO:0032553	ribonucleotide binding	"Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	8	0.003127	1
GO:MF	GO:0017076	purine nucleotide binding	"Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]	8	0.004062	1
GO:MF	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	8	0.006895	1
GO:MF	GO:1901265	nucleoside phosphate binding	"Binding to nucleoside phosphate." [GOC:TermGenie]	8	0.007287	1
GO:MF	GO:0002161	aminoacyl-tRNA deacylase activity	"The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]	2	0.009425	1
GO:MF	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	8	0.010182	1
GO:MF	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	8	0.010852	1
GO:MF	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	8	0.015506	1

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity	"Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation." [GOC:hjd]	2	0.024775	1
GO:BP	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	"Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]	2	0.028307	1
GO:BP	GO:0006450	regulation of translational fidelity	"Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]	2	0.049474	1

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:00970	Aminoacyl-tRNA biosynthesis	Aminoacyl-tRNA biosynthesis	2	0.02636	1

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-let-7b-5p	hsa-let-7b-5p	hsa-let-7b-5p	6	0.033273	1

Community 2

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0030877	beta-catenin destruction complex	"A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]	2	0.000744	2

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0070411	I-SMAD binding	"Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]	2	0.001476	2
GO:MF	GO:0046332	SMAD binding	"Binding to a SMAD signaling protein." [GOC:ai]	2	0.037580	2

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0009950	dorsal/ventral axis specification	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]	2	0.002798	2
GO:BP	GO:0045668	negative regulation of osteoblast differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]	2	0.043784	2

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:05213	Endometrial cancer	Endometrial cancer	2	0.014672	2
KEGG	KEGG:05217	Basal cell carcinoma	Basal cell carcinoma	2	0.017321	2
KEGG	KEGG:05210	Colorectal cancer	Colorectal cancer	2	0.032299	2

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP4155	Endometrial cancer	Endometrial cancer	2	0.025605	2
WP	WP:WP4216	Chromosomal and microsatellite instability in colorectal cancer	Chromosomal and microsatellite instability in colorectal cancer	2	0.034402	2

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-4641257	Degradation of AXIN	Degradation of AXIN	2	0.048203	2

Community 3

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:00785	Lipoic acid metabolism	Lipoic acid metabolism	1	0.036474	3

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0036255	response to methylamine	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [GOC:mah]	1	0.049542	3
GO:BP	GO:1903442	response to lipoic acid	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760]	1	0.049542	3

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0004375	glycine dehydrogenase (decarboxylating) activity	"Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2]	1	0.049891	3
GO:MF	GO:0016642	oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai]	1	0.049891	3
GO:MF	GO:0070280	pyridoxal binding	"Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6." [CHEBI:17310, GOC:mah]	1	0.049891	3

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M12100_1	Factor: ZNF524; motif: NCTCGNACCCNN; match class: 1	Factor: ZNF524; motif: NCTCGNACCCNN; match class: 1	3	0.002245	8
TF	TF:M00800_1	Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1	Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1	9	0.012688	8
TF	TF:M09973_1	Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1	Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1	10	0.029771	8

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:6960	BICD2-dynein-dynactin complex	BICD2-dynein-dynactin complex	3	2.606835e-08	10
CORUM	CORUM:6039	Dynein-dynactin complex	Dynein-dynactin complex	2	4.401642e-04	10

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5085	Vasopressin regulated water reabsorption	Vasopressin regulated water reabsorption	4	9.092633e-07	10
WP	WP:WP5376	17p13 3 YWHAE copy number variation	17p13 3 YWHAE copy number variation	3	2.604993e-05	10
WP	WP:WP5443	Effects of MFN2 mutation	Effects of MFN2 mutation	2	1.180077e-02	10
WP	WP:WP4532	Intraflagellar transport proteins binding to dynein	Intraflagellar transport proteins binding to dynein	2	1.499376e-02	10

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0006469	negative regulation of protein kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	3	0.015753	11
GO:BP	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]	2	0.017895	11
GO:BP	GO:0033673	negative regulation of kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	3	0.018271	11
GO:BP	GO:1904030	negative regulation of cyclin-dependent protein kinase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177]	2	0.022491	11
GO:BP	GO:0051348	negative regulation of transferase activity	"Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]	3	0.027879	11

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4.-, GOC:mah]	3	0.000005	12
GO:MF	GO:0003756	protein disulfide isomerase activity	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]	3	0.000005	12
GO:MF	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	3	0.000032	12
GO:MF	GO:0015036	disulfide oxidoreductase activity	"Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [GOC:curators]	3	0.000053	12
GO:MF	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.8.-.-, GOC:ai]	3	0.000141	12
GO:MF	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	3	0.000149	12
GO:MF	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	6	0.035696	12

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M00687	Factor: alpha-CP1; motif: CAGCCAATGAG	Factor: alpha-CP1; motif: CAGCCAATGAG	7	0.003082	12
TF	TF:M12616	Factor: HMGXB3; motif: NRGCCAATSRGNRNNS	Factor: HMGXB3; motif: NRGCCAATSRGNRNNS	7	0.012016	12
TF	TF:M04683	Factor: NF-YA; motif: YTCTSATTGGYYRN	Factor: NF-YA; motif: YTCTSATTGGYYRN	6	0.012458	12
TF	TF:M12616_1	Factor: HMGXB3; motif: NRGCCAATSRGNRNNS; match class: 1	Factor: HMGXB3; motif: NRGCCAATSRGNRNNS; match class: 1	4	0.049700	12

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-4783-3p	hsa-mir-4783-3p	hsa-mir-4783-3p	4	0.000092	13
MIRNA	MIRNA:hsa-mir-4285	hsa-mir-4285	hsa-mir-4285	3	0.000434	13
MIRNA	MIRNA:hsa-mir-3179	hsa-mir-3179	hsa-mir-3179	6	0.000697	13
MIRNA	MIRNA:hsa-mir-3065-5p	hsa-mir-3065-5p	hsa-mir-3065-5p	6	0.001598	13
MIRNA	MIRNA:hsa-mir-1909	hsa-mir-1909	hsa-mir-1909	6	0.001815	13
MIRNA	MIRNA:hsa-mir-2467-3p	hsa-mir-2467-3p	hsa-mir-2467-3p	6	0.006181	13
MIRNA	MIRNA:hsa-mir-570	hsa-mir-570	hsa-mir-570	6	0.006316	13
MIRNA	MIRNA:hsa-mir-3156-3p	hsa-mir-3156-3p	hsa-mir-3156-3p	5	0.007690	13
MIRNA	MIRNA:hsa-mir-106b-5p	hsa-mir-106b-5p	hsa-mir-106b-5p	5	0.007726	13
MIRNA	MIRNA:hsa-mir-4283	hsa-mir-4283	hsa-mir-4283	5	0.007726	13
MIRNA	MIRNA:hsa-mir-1976	hsa-mir-1976	hsa-mir-1976	6	0.007993	13
MIRNA	MIRNA:hsa-mir-3188	hsa-mir-3188	hsa-mir-3188	5	0.008173	13
MIRNA	MIRNA:hsa-mir-3977	hsa-mir-3977	hsa-mir-3977	5	0.008483	13
MIRNA	MIRNA:hsa-mir-519a	hsa-mir-519a	hsa-mir-519a	5	0.012323	13
MIRNA	MIRNA:hsa-mir-3925-5p	hsa-mir-3925-5p	hsa-mir-3925-5p	5	0.014045	13
MIRNA	MIRNA:hsa-mir-3680	hsa-mir-3680	hsa-mir-3680	4	0.021011	13
MIRNA	MIRNA:hsa-mir-627	hsa-mir-627	hsa-mir-627	4	0.023361	13
MIRNA	MIRNA:hsa-mir-1322	hsa-mir-1322	hsa-mir-1322	4	0.023668	13
MIRNA	MIRNA:hsa-mir-4449	hsa-mir-4449	hsa-mir-4449	3	0.025129	13
MIRNA	MIRNA:hsa-mir-4472	hsa-mir-4472	hsa-mir-4472	5	0.028348	13
MIRNA	MIRNA:hsa-mir-4447	hsa-mir-4447	hsa-mir-4447	5	0.028348	13
MIRNA	MIRNA:hsa-mir-625	hsa-mir-625	hsa-mir-625	5	0.031199	13
MIRNA	MIRNA:hsa-mir-299-5p	hsa-mir-299-5p	hsa-mir-299-5p	4	0.033731	13
MIRNA	MIRNA:hsa-mir-1253	hsa-mir-1253	hsa-mir-1253	5	0.038086	13
MIRNA	MIRNA:hsa-mir-185	hsa-mir-185	hsa-mir-185	5	0.038086	13
MIRNA	MIRNA:hsa-mir-4723-5p	hsa-mir-4723-5p	hsa-mir-4723-5p	5	0.039782	13
MIRNA	MIRNA:hsa-mir-4801	hsa-mir-4801	hsa-mir-4801	5	0.040450	13
MIRNA	MIRNA:hsa-mir-4731-3p	hsa-mir-4731-3p	hsa-mir-4731-3p	5	0.040585	13
MIRNA	MIRNA:hsa-mir-3978	hsa-mir-3978	hsa-mir-3978	5	0.042089	13
MIRNA	MIRNA:hsa-mir-525-5p	hsa-mir-525-5p	hsa-mir-525-5p	5	0.044067	13
MIRNA	MIRNA:hsa-mir-520a-5p	hsa-mir-520a-5p	hsa-mir-520a-5p	5	0.044211	13
MIRNA	MIRNA:hsa-mir-4306	hsa-mir-4306	hsa-mir-4306	5	0.045229	13
MIRNA	MIRNA:hsa-mir-4644	hsa-mir-4644	hsa-mir-4644	5	0.045671	13
MIRNA	MIRNA:hsa-mir-548ah	hsa-mir-548ah	hsa-mir-548ah	5	0.048550	13

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-426496	Post-transcriptional silencing by small RNAs	Post-transcriptional silencing by small RNAs	2	0.001676	13
REAC	REAC:R-HSA-8948700	Competing endogenous RNAs (ceRNAs) regulate PTEN translation	Competing endogenous RNAs (ceRNAs) regulate PTEN translation	2	0.002234	13
REAC	REAC:R-HSA-8943723	Regulation of PTEN mRNA translation	Regulation of PTEN mRNA translation	2	0.002871	13
REAC	REAC:R-HSA-9768778	Regulation of NPAS4 mRNA translation	Regulation of NPAS4 mRNA translation	2	0.002871	13
REAC	REAC:R-HSA-9759811	Regulation of CDH11 mRNA translation by microRNAs	Regulation of CDH11 mRNA translation by microRNAs	2	0.002871	13
REAC	REAC:R-HSA-9768759	Regulation of NPAS4 gene expression	Regulation of NPAS4 gene expression	2	0.006214	13
REAC	REAC:R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	mRNA decay by 5' to 3' exoribonuclease	2	0.008359	13
REAC	REAC:R-HSA-446728	Cell junction organization	Cell junction organization	3	0.008473	13
REAC	REAC:R-HSA-9824594	Regulation of MITF-M-dependent genes involved in apoptosis	Regulation of MITF-M-dependent genes involved in apoptosis	2	0.010821	13
REAC	REAC:R-HSA-8934593	Regulation of RUNX1 Expression and Activity	Regulation of RUNX1 Expression and Activity	2	0.010821	13
REAC	REAC:R-HSA-3858494	Beta-catenin independent WNT signaling	Beta-catenin independent WNT signaling	3	0.016682	13
REAC	REAC:R-HSA-1500931	Cell-Cell communication	Cell-Cell communication	3	0.019235	13
REAC	REAC:R-HSA-9759475	Regulation of CDH11 Expression and Function	Regulation of CDH11 Expression and Function	2	0.027843	13
REAC	REAC:R-HSA-9022692	Regulation of MECP2 expression and activity	Regulation of MECP2 expression and activity	2	0.032186	13
REAC	REAC:R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	Regulation of Homotypic Cell-Cell Adhesion	2	0.034475	13
REAC	REAC:R-HSA-9764260	Regulation of Expression and Function of Type II Classical Cadherins	Regulation of Expression and Function of Type II Classical Cadherins	2	0.034475	13
REAC	REAC:R-HSA-9634815	Transcriptional Regulation by NPAS4	Transcriptional Regulation by NPAS4	2	0.041807	13
REAC	REAC:R-HSA-2559585	Oncogene Induced Senescence	Oncogene Induced Senescence	2	0.041807	13
REAC	REAC:R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	2	0.049838	13

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0043507	positive regulation of JUN kinase activity	"Any process that activates or increases the frequency, rate or extent of JUN kinase activity." [GOC:jl]	4	7.525109e-08	14
GO:BP	GO:0043506	regulation of JUN kinase activity	"Any process that modulates the frequency, rate or extent of JUN kinase activity." [GOC:jl]	4	3.521935e-07	14
GO:BP	GO:0071900	regulation of protein serine/threonine kinase activity	"Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	5	3.994503e-06	14
GO:BP	GO:0043406	positive regulation of MAP kinase activity	"Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	4	4.145279e-06	14
GO:BP	GO:0000165	MAPK cascade	"An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]	6	1.306946e-05	14
GO:BP	GO:0043405	regulation of MAP kinase activity	"Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	4	2.934608e-05	14
GO:BP	GO:0045859	regulation of protein kinase activity	"Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	5	5.071694e-05	14
GO:BP	GO:0038095	Fc-epsilon receptor signaling pathway	"The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:12413516, PMID:15048725]	3	5.180542e-05	14
GO:BP	GO:0071902	positive regulation of protein serine/threonine kinase activity	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	4	5.773435e-05	14
GO:BP	GO:0043549	regulation of kinase activity	"Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf]	5	7.180037e-05	14
GO:BP	GO:0031399	regulation of protein modification process	"Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	6	1.019588e-04	14
GO:BP	GO:0051338	regulation of transferase activity	"Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai]	5	1.475377e-04	14
GO:BP	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	6	2.596797e-04	14
GO:BP	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	6	4.012847e-04	14
GO:BP	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	5	5.017350e-04	14
GO:BP	GO:0045860	positive regulation of protein kinase activity	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	4	5.547539e-04	14
GO:BP	GO:0038093	Fc receptor signaling pathway	"The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, Wikipedia:Fc_receptor]	3	6.917345e-04	14
GO:BP	GO:0033674	positive regulation of kinase activity	"Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	4	7.075279e-04	14
GO:BP	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	7	8.271313e-04	14
GO:BP	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	3	1.172731e-03	14
GO:BP	GO:0043412	macromolecule modification	"The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]	7	1.282991e-03	14
GO:BP	GO:0051347	positive regulation of transferase activity	"Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]	4	1.302991e-03	14
GO:BP	GO:0001932	regulation of protein phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]	5	1.360464e-03	14
GO:BP	GO:0051865	protein autoubiquitination	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]	3	1.571946e-03	14
GO:BP	GO:0042325	regulation of phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]	5	1.861754e-03	14
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	6	3.029501e-03	14
GO:BP	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	5	3.230979e-03	14
GO:BP	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	5	3.570753e-03	14
GO:BP	GO:0141124	intracellular signaling cassette	"An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg]	6	3.624489e-03	14
GO:BP	GO:0019220	regulation of phosphate metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	5	3.741287e-03	14
GO:BP	GO:0051174	regulation of phosphorus metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]	5	3.760627e-03	14
GO:BP	GO:0097400	interleukin-17-mediated signaling pathway	"The series of molecular signals initiated by interleukin-17 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ic, PMID:21602493]	2	5.217945e-03	14
GO:BP	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	5	5.638997e-03	14
GO:BP	GO:0043410	positive regulation of MAPK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]	4	7.256137e-03	14
GO:BP	GO:0048583	regulation of response to stimulus	"Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	7	8.870479e-03	14
GO:BP	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	4	9.111604e-03	14
GO:BP	GO:0046328	regulation of JNK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]	3	9.916865e-03	14
GO:BP	GO:0042327	positive regulation of phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]	4	1.095203e-02	14
GO:BP	GO:0023035	CD40 signaling pathway	"The series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mtg_signal, GOC:signaling, PMID:11348017]	2	1.137558e-02	14
GO:BP	GO:0097398	cellular response to interleukin-17	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr]	2	1.289028e-02	14
GO:BP	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	6	1.413408e-02	14
GO:BP	GO:0006793	phosphorus metabolic process	"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]	6	1.423828e-02	14
GO:BP	GO:0097396	response to interleukin-17	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr]	2	1.449927e-02	14
GO:BP	GO:0043085	positive regulation of catalytic activity	"Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	4	1.566590e-02	14
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	4	1.634615e-02	14
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]	4	1.634615e-02	14
GO:BP	GO:0007254	JNK cascade	"A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation." [PMID:11790549, PMID:20811974, PMID:23125017]	3	1.935562e-02	14
GO:BP	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	4	2.715735e-02	14
GO:BP	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	7	2.867098e-02	14
GO:BP	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	5	3.011444e-02	14
GO:BP	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	5	3.369166e-02	14
GO:BP	GO:0043067	regulation of programmed cell death	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	5	3.480513e-02	14
GO:BP	GO:0002726	positive regulation of T cell cytokine production	"Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add]	2	3.576495e-02	14
GO:BP	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	6	3.582721e-02	14
GO:BP	GO:0034612	response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	3	4.321196e-02	14
GO:BP	GO:0002682	regulation of immune system process	"Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]	5	4.411334e-02	14
GO:BP	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	6	4.819192e-02	14

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0035631	CD40 receptor complex	"A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules." [GOC:BHF, PMID:20614026, PMID:9221764]	2	0.000742	14
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	7	0.009560	14
GO:CC	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	2	0.011009	14

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0200146	Mucoid extracellular matrix accumulation	An increase of medial mucoid extracellular matrix creating translamellar and/or intralamellar expansions including extracellular pools as noted on an H&E stain and/or a stain to highlight extracellular matrix material (Movat's pentachrome, Alcian blue, etc.).	2	0.028340	15
HP	HP:0032079	Medial degeneration	Medial degeneration of the aorta is to be used as an overarching term for any aortic surgical specimens that demonstrate one or more of the specific histopathologies mucoid extracellular matrix accumulation, elastic fiber fragmentation and/or loss, elastic fiber thinning, elastic fiber disorganization, smooth muscle cell nuclei loss, laminar medial collapse, smooth muscle cell disorganization, medial fibrosis. Grading of medial degeneration is based on the average overall severity of specific histopathologies as described, considering the worst area(s) sampled from multiple slides and aorta sections.	2	0.028340	15
HP	HP:0004959	Descending thoracic aorta aneurysm	An abnormal localized widening (dilatation) of the descending thoracic aorta.	2	0.028340	15
HP	HP:0012180	Cystic medial necrosis	A disorder of large arteries, in particular the aorta, characterized by an accumulation of basophilic ground substance in the media with cyst-like lesions associated with degenerative changes of collagen, elastin and the vascular smooth muscle cells.	2	0.028340	15
HP	HP:0012763	Paroxysmal dyspnea	A sudden attack of dyspnea that occurs while the affected person is at rest.	2	0.031485	15
HP	HP:0012499	Descending aortic dissection	A separation of the layers within the wall of the descending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space.	2	0.034795	15
HP	HP:0012163	Carotid artery dilatation	A dilatation (balooning or bulging out of the vessel wall) of a carotid artery.	2	0.041909	15
HP	HP:0005112	Abdominal aortic aneurysm	An abnormal localized widening (dilatation) of the abdominal aorta.	2	0.045712	15
HP	HP:0100775	Dural ectasia	A widening or ballooning of the dural sac surrounding the spinal cord usually at the lumbosacral level.	2	0.045712	15
HP	HP:0012432	Chronic fatigue	Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer.	2	0.049681	15
HP	HP:0010303	Abnormal spinal meningeal morphology	Any abnormality of the spinal meninges, the system of membranes (dura mater, the arachnoid mater, and the pia mater) which envelops the spinal cord.	2	0.049681	15

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-186763	Downstream signal transduction	Downstream signal transduction	3	0.000053	16
REAC	REAC:R-HSA-109704	PI3K Cascade	PI3K Cascade	3	0.000144	16
REAC	REAC:R-HSA-112399	IRS-mediated signalling	IRS-mediated signalling	3	0.000184	16
REAC	REAC:R-HSA-2428928	IRS-related events triggered by IGF1R	IRS-related events triggered by IGF1R	3	0.000248	16
REAC	REAC:R-HSA-2428924	IGF1R signaling cascade	IGF1R signaling cascade	3	0.000248	16
REAC	REAC:R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	3	0.000266	16
REAC	REAC:R-HSA-74751	Insulin receptor signalling cascade	Insulin receptor signalling cascade	3	0.000285	16
REAC	REAC:R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	Signaling by Receptor Tyrosine Kinases	5	0.000289	16
REAC	REAC:R-HSA-186797	Signaling by PDGF	Signaling by PDGF	3	0.000498	16
REAC	REAC:R-HSA-9603381	Activated NTRK3 signals through PI3K	Activated NTRK3 signals through PI3K	2	0.000836	16
REAC	REAC:R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	Constitutive Signaling by Aberrant PI3K in Cancer	3	0.000875	16
REAC	REAC:R-HSA-76002	Platelet activation, signaling and aggregation	Platelet activation, signaling and aggregation	4	0.000976	16
REAC	REAC:R-HSA-5684996	MAPK1/MAPK3 signaling	MAPK1/MAPK3 signaling	4	0.001169	16
REAC	REAC:R-HSA-74752	Signaling by Insulin receptor	Signaling by Insulin receptor	3	0.001244	16
REAC	REAC:R-HSA-6806834	Signaling by MET	Signaling by MET	3	0.001405	16
REAC	REAC:R-HSA-5683057	MAPK family signaling cascades	MAPK family signaling cascades	4	0.001996	16
REAC	REAC:R-HSA-2586552	Signaling by Leptin	Signaling by Leptin	2	0.002006	16
REAC	REAC:R-HSA-198203	PI3K/AKT activation	PI3K/AKT activation	2	0.002006	16
REAC	REAC:R-HSA-2219528	PI3K/AKT Signaling in Cancer	PI3K/AKT Signaling in Cancer	3	0.002421	16
REAC	REAC:R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	3	0.002502	16
REAC	REAC:R-HSA-4420097	VEGFA-VEGFR2 Pathway	VEGFA-VEGFR2 Pathway	3	0.002669	16
REAC	REAC:R-HSA-9842663	Signaling by LTK	Signaling by LTK	2	0.003063	16
REAC	REAC:R-HSA-199418	Negative regulation of the PI3K/AKT network	Negative regulation of the PI3K/AKT network	3	0.003120	16
REAC	REAC:R-HSA-194138	Signaling by VEGF	Signaling by VEGF	3	0.003619	16
REAC	REAC:R-HSA-5654710	PI-3K cascade:FGFR3	PI-3K cascade:FGFR3	2	0.004341	16
REAC	REAC:R-HSA-9034015	Signaling by NTRK3 (TRKC)	Signaling by NTRK3 (TRKC)	2	0.005064	16
REAC	REAC:R-HSA-391160	Signal regulatory protein family interactions	Signal regulatory protein family interactions	2	0.005064	16
REAC	REAC:R-HSA-5654689	PI-3K cascade:FGFR1	PI-3K cascade:FGFR1	2	0.005841	16
REAC	REAC:R-HSA-9703648	Signaling by FLT3 ITD and TKD mutants	Signaling by FLT3 ITD and TKD mutants	2	0.005841	16
REAC	REAC:R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	p130Cas linkage to MAPK signaling for integrins	2	0.005841	16
REAC	REAC:R-HSA-210993	Tie2 Signaling	Tie2 Signaling	2	0.006674	16
REAC	REAC:R-HSA-180292	GAB1 signalosome	GAB1 signalosome	2	0.006674	16
REAC	REAC:R-HSA-166520	Signaling by NTRKs	Signaling by NTRKs	3	0.007072	16
REAC	REAC:R-HSA-5654720	PI-3K cascade:FGFR4	PI-3K cascade:FGFR4	2	0.007562	16
REAC	REAC:R-HSA-5654708	Downstream signaling of activated FGFR3	Downstream signaling of activated FGFR3	2	0.008505	16
REAC	REAC:R-HSA-5654695	PI-3K cascade:FGFR2	PI-3K cascade:FGFR2	2	0.008505	16
REAC	REAC:R-HSA-1500931	Cell-Cell communication	Cell-Cell communication	3	0.010853	16
REAC	REAC:R-HSA-9006115	Signaling by NTRK2 (TRKB)	Signaling by NTRK2 (TRKB)	2	0.011665	16
REAC	REAC:R-HSA-5654716	Downstream signaling of activated FGFR4	Downstream signaling of activated FGFR4	2	0.012829	16
REAC	REAC:R-HSA-5654687	Downstream signaling of activated FGFR1	Downstream signaling of activated FGFR1	2	0.014047	16
REAC	REAC:R-HSA-5654696	Downstream signaling of activated FGFR2	Downstream signaling of activated FGFR2	2	0.014047	16
REAC	REAC:R-HSA-354192	Integrin signaling	Integrin signaling	2	0.018032	16
REAC	REAC:R-HSA-9682385	FLT3 signaling in disease	FLT3 signaling in disease	2	0.019469	16
REAC	REAC:R-HSA-201556	Signaling by ALK	Signaling by ALK	2	0.020962	16
REAC	REAC:R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	Signaling by CSF1 (M-CSF) in myeloid cells	2	0.024111	16
REAC	REAC:R-HSA-5654741	Signaling by FGFR3	Signaling by FGFR3	2	0.027479	16
REAC	REAC:R-HSA-114604	GPVI-mediated activation cascade	GPVI-mediated activation cascade	2	0.032940	16
REAC	REAC:R-HSA-5654743	Signaling by FGFR4	Signaling by FGFR4	2	0.032940	16
REAC	REAC:R-HSA-9607240	FLT3 Signaling	FLT3 Signaling	2	0.034869	16
REAC	REAC:R-HSA-1266695	Interleukin-7 signaling	Interleukin-7 signaling	2	0.036852	16
REAC	REAC:R-HSA-76009	Platelet Aggregation (Plug Formation)	Platelet Aggregation (Plug Formation)	2	0.038890	16
REAC	REAC:R-HSA-8853659	RET signaling	RET signaling	2	0.038890	16
REAC	REAC:R-HSA-1433557	Signaling by SCF-KIT	Signaling by SCF-KIT	2	0.040982	16
REAC	REAC:R-HSA-109582	Hemostasis	Hemostasis	4	0.042922	16
REAC	REAC:R-HSA-5654736	Signaling by FGFR1	Signaling by FGFR1	2	0.049894	16
REAC	REAC:R-HSA-373752	Netrin-1 signaling	Netrin-1 signaling	2	0.049894	16

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:1751	SMN complex	SMN complex	3	0.000001	17
CORUM	CORUM:1143	SMN complex	SMN complex	3	0.000009	17
CORUM	CORUM:824	Anti-SMN protein complex	Anti-SMN protein complex	2	0.000132	17
CORUM	CORUM:3296	SMN complex (GEMIN5,4,3), SMN-independent intermediate	SMN complex (GEMIN5,4,3), SMN-independent intermediate	2	0.000132	17
CORUM	CORUM:1750	PPP4C-PPP4R2-Gemin3-Gemin4 complex	PPP4C-PPP4R2-Gemin3-Gemin4 complex	2	0.000264	17
CORUM	CORUM:3284	SMN complex (GEMIN2, GEMIN3, GEMIN4, GEMIN5, SMN)	SMN complex (GEMIN2, GEMIN3, GEMIN4, GEMIN5, SMN)	2	0.000264	17
CORUM	CORUM:832	Anti-Sm protein complex	Anti-Sm protein complex	2	0.000440	17
CORUM	CORUM:1752	SMN complex	SMN complex	2	0.000660	17
CORUM	CORUM:1749	SMN-PolII-RHA complex	SMN-PolII-RHA complex	2	0.001231	17
CORUM	CORUM:1745	SMN complex	SMN complex	2	0.003991	17

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-194441	Metabolism of non-coding RNA	Metabolism of non-coding RNA	2	0.011538	17
REAC	REAC:R-HSA-9754678	SARS-CoV-2 modulates host translation machinery	SARS-CoV-2 modulates host translation machinery	2	0.011538	17
REAC	REAC:R-HSA-191859	snRNP Assembly	snRNP Assembly	2	0.011538	17

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-444257	RSK activation	RSK activation	2	0.000191	18
REAC	REAC:R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	Gastrin-CREB signalling pathway via PKC and MAPK	2	0.000952	18
REAC	REAC:R-HSA-198753	ERK/MAPK targets	ERK/MAPK targets	2	0.002094	18
REAC	REAC:R-HSA-442742	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	2	0.002719	18
REAC	REAC:R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	MAPK targets/ Nuclear events mediated by MAP kinases	2	0.003941	18
REAC	REAC:R-HSA-9856649	Transcriptional and post-translational regulation of MITF-M expression and activity	Transcriptional and post-translational regulation of MITF-M expression and activity	2	0.006032	18
REAC	REAC:R-HSA-437239	Recycling pathway of L1	Recycling pathway of L1	2	0.010209	18
REAC	REAC:R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	Nuclear Events (kinase and transcription factor activation)	2	0.016008	18
REAC	REAC:R-HSA-450294	MAP kinase activation	MAP kinase activation	2	0.017100	18
REAC	REAC:R-HSA-448424	Interleukin-17 signaling	Interleukin-17 signaling	2	0.021828	18
REAC	REAC:R-HSA-438064	Post NMDA receptor activation events	Post NMDA receptor activation events	2	0.025075	18
REAC	REAC:R-HSA-442755	Activation of NMDA receptors and postsynaptic events	Activation of NMDA receptors and postsynaptic events	2	0.034562	18
REAC	REAC:R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	Toll Like Receptor 5 (TLR5) Cascade	2	0.040296	18
REAC	REAC:R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	Toll Like Receptor 10 (TLR10) Cascade	2	0.040296	18
REAC	REAC:R-HSA-975871	MyD88 cascade initiated on plasma membrane	MyD88 cascade initiated on plasma membrane	2	0.040296	18
REAC	REAC:R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	2	0.044660	18
REAC	REAC:R-HSA-975155	MyD88 dependent cascade initiated on endosome	MyD88 dependent cascade initiated on endosome	2	0.045559	18
REAC	REAC:R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	Toll Like Receptor 7/8 (TLR7/8) Cascade	2	0.046467	18
REAC	REAC:R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	Toll Like Receptor 3 (TLR3) Cascade	2	0.047385	18
REAC	REAC:R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	Toll Like Receptor 9 (TLR9) Cascade	2	0.049246	18

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5231	Hippocampal synaptogenesis and neurogenesis	Hippocampal synaptogenesis and neurogenesis	2	0.003640	18
WP	WP:WP3676	BDNF TrkB signaling	BDNF TrkB signaling	2	0.006954	18
WP	WP:WP4877	Host pathogen interaction of human coronaviruses MAPK signaling	Host pathogen interaction of human coronaviruses MAPK signaling	2	0.008294	18
WP	WP:WP127	IL5 signaling	IL5 signaling	2	0.008766	18
WP	WP:WP2332	IL11 signaling	IL11 signaling	2	0.012439	18
WP	WP:WP5493	Effect of dasatinib on the BCR ABL signaling pathway	Effect of dasatinib on the BCR ABL signaling pathway	2	0.013015	18
WP	WP:WP4566	Translation inhibitors in chronically activated PDGFRA cells	Translation inhibitors in chronically activated PDGFRA cells	2	0.013605	18
WP	WP:WP304	Kit receptor signaling	Kit receptor signaling	2	0.018094	18
WP	WP:WP5510	16p12 2 copy number variation syndrome 520kb	16p12 2 copy number variation syndrome 520kb	2	0.018787	18
WP	WP:WP2032	Thyroid stimulating hormone TSH signaling	Thyroid stimulating hormone TSH signaling	2	0.021688	18
WP	WP:WP2034	Leptin signaling	Leptin signaling	2	0.032540	18
WP	WP:WP5094	Orexin receptor pathway	Orexin receptor pathway	2	0.049995	18

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-5357786	TNFR1-induced proapoptotic signaling	TNFR1-induced proapoptotic signaling	2	0.005025	19
REAC	REAC:R-HSA-5357905	Regulation of TNFR1 signaling	Regulation of TNFR1 signaling	2	0.017294	19
REAC	REAC:R-HSA-75893	TNF signaling	TNF signaling	2	0.024786	19

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5202	Alstrom syndrome	Alstrom syndrome	2	0.006534	22
WP	WP:WP5504	Disorders of mitochondrial homeostatis dynamics protein import and quality control	Disorders of mitochondrial homeostatis dynamics protein import and quality control	2	0.024000	22

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005834	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684]	3	0.000009	23
GO:CC	GO:1905360	GTPase complex	"A protein complex which is capable of GTPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9178006]	3	0.000014	23
GO:CC	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]	3	0.000029	23
GO:CC	GO:0019897	extrinsic component of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]	3	0.000284	23
GO:CC	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	3	0.000888	23
GO:CC	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	3	0.001357	23
GO:CC	GO:0098562	cytoplasmic side of membrane	"The side of a membrane that faces the cytoplasm." [GOC:dos]	3	0.001833	23

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:7087	GNAI1-GNB2-GNG12 complex	GNAI1-GNB2-GNG12 complex	2	0.000132	23
CORUM	CORUM:7205	GNAS-L-GNB2-GNG12 complex	GNAS-L-GNB2-GNG12 complex	2	0.000132	23
CORUM	CORUM:7204	GNAS-L-GNB1-GNG12 complex	GNAS-L-GNB1-GNG12 complex	2	0.000132	23

biogrid+hippie (Leiden)

Community 0

GO:MF

GO:BP

GO:CC

HPA

MIRNA

WP

REAC

KEGG

HP

TF

CORUM

Community 1

GO:CC

REAC

WP

GO:BP

KEGG

CORUM

GO:MF

HP

HPA

MIRNA

TF

Community 2

GO:CC

REAC

CORUM

GO:MF

KEGG

WP

GO:BP

HPA

Community 3

GO:CC

GO:BP

GO:MF

KEGG

MIRNA

Community 4

MIRNA

HPA

WP

GO:MF

Community 5

GO:BP

GO:MF

GO:CC

WP

CORUM

HPA

Community 6

GO:BP

GO:CC

WP

GO:MF

CORUM

REAC

KEGG

TF

Community 7

GO:CC

GO:BP

WP

REAC

MIRNA

CORUM

Community 8

GO:CC

HPA

GO:BP

GO:MF

REAC

KEGG

TF

MIRNA

WP

CORUM

Community 9

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-611105	Respiratory electron transport	Respiratory electron transport	3	0.000691	25
REAC	REAC:R-HSA-1428517	Aerobic respiration and respiratory electron transport	Aerobic respiration and respiratory electron transport	3	0.004516	25
REAC	REAC:R-HSA-6799198	Complex I biogenesis	Complex I biogenesis	2	0.026632	25

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:2948	Respiratory chain complex I (incomplete intermediate), mitochondrial	Respiratory chain complex I (incomplete intermediate), mitochondrial	2	0.001623	25
CORUM	CORUM:178	Respiratory chain complex I (holoenzyme), mitochondrial	Respiratory chain complex I (holoenzyme), mitochondrial	2	0.027733	25

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0009060	aerobic respiration	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590]	3	0.002212	25
GO:BP	GO:0045333	cellular respiration	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732]	3	0.003982	25
GO:BP	GO:0019637	organophosphate metabolic process	"The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]	4	0.004565	25
GO:BP	GO:0015980	energy derivation by oxidation of organic compounds	"The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah]	3	0.011537	25
GO:BP	GO:0006163	purine nucleotide metabolic process	"The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	3	0.022308	25
GO:BP	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	2	0.023002	25
GO:BP	GO:0006091	generation of precursor metabolites and energy	"The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]	3	0.030612	25
GO:BP	GO:0009117	nucleotide metabolic process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]	3	0.033573	25
GO:BP	GO:0044281	small molecule metabolic process	"The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	4	0.033831	25
GO:BP	GO:0010257	NADH dehydrogenase complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex." [GOC:sm]	2	0.035206	25
GO:BP	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	2	0.035206	25
GO:BP	GO:0042776	proton motive force-driven mitochondrial ATP synthesis	"The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force)." [GOC:vw]	2	0.039847	25
GO:BP	GO:0072521	purine-containing compound metabolic process	"The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	3	0.049912	25

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	4	0.010105	26
GO:CC	GO:0098827	endoplasmic reticulum subcompartment	"A distinct region of the endoplasmic reticulum." [GOC:dos]	4	0.010301	26
GO:CC	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network	"The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]	4	0.010941	26
GO:CC	GO:0031984	organelle subcompartment	"A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz]	4	0.025729	26

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	NOTCH2 Activation and Transmission of Signal to the Nucleus	2	0.002094	27
REAC	REAC:R-HSA-1980145	Signaling by NOTCH2	Signaling by NOTCH2	2	0.004494	27
REAC	REAC:R-HSA-9013694	Signaling by NOTCH4	Signaling by NOTCH4	2	0.029266	27
REAC	REAC:R-HSA-192823	Viral mRNA Translation	Viral mRNA Translation	2	0.036156	27
REAC	REAC:R-HSA-156902	Peptide chain elongation	Peptide chain elongation	2	0.036156	27
REAC	REAC:R-HSA-2408557	Selenocysteine synthesis	Selenocysteine synthesis	2	0.039450	27
REAC	REAC:R-HSA-72764	Eukaryotic Translation Termination	Eukaryotic Translation Termination	2	0.039450	27
REAC	REAC:R-HSA-156842	Eukaryotic Translation Elongation	Eukaryotic Translation Elongation	2	0.039450	27
REAC	REAC:R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	2	0.041151	27
REAC	REAC:R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	Response of EIF2AK4 (GCN2) to amino acid deficiency	2	0.046467	27
REAC	REAC:R-HSA-72689	Formation of a pool of free 40S subunits	Formation of a pool of free 40S subunits	2	0.046467	27

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0008424	Hypoplastic 5th lumbar vertebrae	Hypoplastic 5th lumbar vertebrae	1	0.049962	27
HP	HP:0005463	Elongated sella turcica	Elongated sella turcica	1	0.049962	27
HP	HP:0006180	Crowded carpal bones	Crowded carpal bones	1	0.049962	27
HP	HP:0008421	Tall lumbar vertebral bodies	Tall lumbar vertebral bodies	1	0.049962	27
HP	HP:0011305	Partial absence of toe	The absence of a phalangeal segment of a toe or hallux.	1	0.049962	27

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5501	GNAQ p R183Q drives capillary malformation	GNAQ p R183Q drives capillary malformation	3	0.000001	29
WP	WP:WP5142	Calcium mediated T cell apoptosis involved in inclusion body myositis	Calcium mediated T cell apoptosis involved in inclusion body myositis	2	0.000970	29
WP	WP:WP3414	Initiation of transcription and translation elongation at the HIV 1 LTR	Initiation of transcription and translation elongation at the HIV 1 LTR	2	0.002531	29
WP	WP:WP2447	Amyotrophic lateral sclerosis ALS	Amyotrophic lateral sclerosis ALS	2	0.003585	29
WP	WP:WP1541	Energy metabolism	Energy metabolism	2	0.005509	29
WP	WP:WP35	G protein signaling	G protein signaling	2	0.019892	29
WP	WP:WP1544	MicroRNAs in cardiomyocyte hypertrophy	MicroRNAs in cardiomyocyte hypertrophy	2	0.027176	29
WP	WP:WP428	Wnt signaling	Wnt signaling	2	0.032085	29

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:2266	PPP3CA-PPP3CA-RCAN1 complex	PPP3CA-PPP3CA-RCAN1 complex	2	0.000015	29
CORUM	CORUM:517	AKAP5-PRKAR2A-PPP3CA complex	AKAP5-PRKAR2A-PPP3CA complex	1	0.049932	29

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005955	calcineurin complex	"A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [PMID:26794871]	2	0.000034	29
GO:CC	GO:1903293	phosphatase complex	"A protein complex which is capable of phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807]	2	0.003470	29
GO:CC	GO:0008287	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	2	0.003470	29

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0007525	Yellow subcutaneous tissue covered by thin, scaly skin	Yellow subcutaneous tissue covered by thin, scaly skin	1	0.049962	30
HP	HP:0034691	Reduced 3-phosphoglycerate dehydrogenase activity	Diminished activity of the enzyme 3-phosphoglycerate dehydrogenase (PGDH), which catalyzes the first step in the pathway by converting D-3-phosphoglycerate (PGA), an intermediate in glycolysis, to phosphohydroxypyruvate concomitant with the reduction of NAD+.	1	0.049962	30